Osteosarcoma (bone cancer)

Osteosarcoma is the most common bone tumor of the dog. This cancer develops in the bone, usually the limbs, and as the tumor grows it becomes progressively more painful for the dog and can result in lameness. Often these tumors metastasize to the lungs. Giant breeds are at the greatest risk for developing osteosarcomas.

Latest Research Update: To date, we have collected ~500 samples from dogs diagnosed with osteosarcoma and ~1500 healthy dogs over 8 years old. We started out by studying Greyhounds, Rottweilers and Irish Wolfhounds. In each of the breeds we find both novel genes and genes that are known to influence the risk of developing bone cancer. We are currently working to confirm this and to identify the precise mutations that cause the disease.

Breeds: Borzoi, Golden Retriever, Great Dane, Great Pyrenees, Greyhound, Irish Wolfhound, Labrador Retriever, Leonberger, Mastiff, Rottweiler, Scottish Deerhound

Publication: Scott et al. Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach. (2011) Bone, May 15. [Epub ahead of print]

Main collaborators: Jaime Modiano (University of Minnesota), Matthew Breen (North Carolina State University), Cheryl London (Ohio State University), Guillermo Couto (Ohio State University), Emma Ivansson (Uppsala University), Mike Starkey (Animal Health Trust), Logan Spector (University of Minnesota) and Fredrik Mertens (Lund University)

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