Obsessive Compulsive Disorder (OCD)

Obsessive-compulsive disorder (CCD) is characterized by time-consuming, repetitive behaviors causing distress and functional impairment. CCDs derive from normal behaviors such as grooming, predatory behavior, eating/suckling or locomotion. They commonly appear between pre-pubescence and early social maturity1 and may be precipitated by anxiety or stress.

Latest Research Update: We have identified regions in the genome associated with CCD and we are now scrutinizing the regions as well as potential fixed breed-specific regions (selective sweep signals) encompassing CSTC circuit candidate genes.

Breeds: Bull Terrier, Doberman Pinscher, German Shepherd, Shetland Sheepdog, West Highland White Terrier, Shiba, Jack Russell Terrier

Publication: Dodman et al. A canine chromosome 7 locus confers compulsive disorder susceptibility. (2010) Mol Psychiatry. 15:8-10.

Main collaborators: Guoping Feng (MIT)

Main contact person: Elinor Karlsson, elinor@broadinstitute.org