Mast Cell Tumors (MCT)

Mast Cell Tumors (MCT) are cancerous proliferations of mast cells. Although they can and will spread throughout the body, the danger from MCTs comes from the secondary damage caused by the release of chemicals the tumors produce. These chemicals can cause systemic problems that include gastric ulcers, internal bleeding, and a range of allergic manifestations.

Latest Research Update: We have compared the genomes of 88 Golden Retrievers with MCT and 103 healthy Golden Retrievers and are very excited to have identified several regions of the genome that appear to be inherited risk factors for mast cell tumors in Golden Retrievers. We are now validating these results in more dogs and looking to identify the exact gene and mutation.

Breeds: Boxers, German Shepherd, Golden Retriever, Labrador Retriever, Pug, Rhodesian Ridgeback, Shar-Pei

Main collaborators: Mike Starkey (AHT, UK), Cheryl London (Ohio State University), Lisa Barber (Tufts University) Malin Melin (Swedish University of Agricultural Science, Sweden), Guiding Eye of the Blind, Maja Arendt (Uppsala University Sweden) and LUPA

Main contact: Malin Melin, malin.melin@slu.se and Maja Arendt maja-louise.arendt@imbim.uu.se