Lymphoma

Lymphoma (LSA) a cancer of the lymphocytes that can occur in the lymph nodes, spleen, liver, and other organs. Characteristics are high white blood cell count, swollen lymph glands, lethargy, and loss of appetite. It is a treatable cancer, but if left untreated, it will eventually lead to death. A number of B- and T-cell subtypes exist.

Latest Research Update: A comparison of the genomes of healthy and golden retrievers with lymphoma have identified several regions associated with the disease and further analysis are ongoing to identify the disease causing variants. Sequencing of tumor samples is ongoing to better understand the consequences of the inherited mutations.

Breeds: Boxer, Cocker Spaniel, Golden Retriever, Irish wolfhound

Main collaborator: Jamie Modiano (University of Minnesota), Matthew Breen (North Carolina State University)

Main contact: Noriko Tonomura, Tonomura@broadinstitute.org