Juvenile Renal Dysplasia (JRD)

Juvenile Renal Dysplasia (JRD) or Renal Dysplasia (RD) is an inherited condition affecting the developmental maturation of the kidney. The key clinical signs of JRD include (but are not limited to) excess water intake and urination from a young age (8 weeks to 2 years of age), and small, irregular-shaped kidneys observed by ultrasound examination. The disease often leads to renal failure.

Latest Research Update: A comparison of the genomes of boxers with RD and their parents is ongoing. Sample collection is ongoing to increase sample numbers and to strengthen the analysis.

Breeds: Boxer, Bernese Mountain Dog, Cocker Spaniel, Miniature Schnauzer, Golden Retriever

Main collaborator: Åke Hedhammar (Swedish University of Agricultural Science), Katarina Tengvall (Uppsala University) and Andrew Lundquist (MGH)

Main contact: Noriko Tonomura Tonomura@broadinstitute.org & Katarina Tengvall, Katarina.tengvall@imbim.uu.se