Hairlessness/Canine Ectodermal Dysplaysia (CED)

The occurrence of a sparse coat of hair and abnormally shaped teeth is known as canine ectodermal dysplaysia (CED), and is characteristic of Chinese crested, Mexican and Peruvian hairless dogs.

Latest Research Update: By comparing the genomes of 20 hairless and 19 coated Chinese crested dogs we were able to identify the dog chromosome that was most associated to the CED trait. To pinpoint the location that was most associated to CED we compared 140 hairless dogs with 55 dogs with hair (including Chinese crested dogs, Mexican hairless dogs and Peruvian hairless dogs) and found the gene most associated to hairlessness. With further research we found a mutation within the most associated gene that is involved in hair development.

Publication:  Drögemüller et al. (2008) A Mutation in Hairless Dogs Implicates FOXI3 in Ectodermal Development. Science DOI: 10.1126/science.1162525

Breeds:  Complete

Collaborators: Hannes Lohi (University of Helsinki) and Tosso Leeb (University of Bern)