Dilated Cardiomyopathy (DCM)

Dilated Cardiomypathy (DCM) is a disease of the heart muscle that can result in enlarged heart chambers, valve leakage and, in turn, weakened contractions and difficulty pumping blood out to the body and lungs. DCM affects many dog breeds but the large breed dogs are in general more prone.

Latest Research Update: DCM is a complex disease and several genes are likely to be involved with and differ slightly between populations. We have identified predisposing mutations in Boxers (ARVC) and Dobermans (DCM) originating from the US population. In the European population of Dobermans, Great Dane, Irish Wolfhounds and Newfoundlands interesting candidate regions in the genome been localized and we are searching for the predisposing mutation.

Breeds: Boxers, Doberman Pinschers, Great Danes, Irish Wolfhounds and Newfoundlands

Main Collaborators: Kathryn Meurs (Washington State University), Göran Andersson, Jens Häggström, Katja Höglund, Susanne Björnerfeldt (Swedish University of Agricultural Science), Jennifer Meadows (Uppsala University), Gerhard Wess (Munich University), Tosso Loeb (University of Bern), Joanna Dukes-McEwan, Hannah Stephenson (University of Liverpool), Anne Thomas (Antagene), Ottmar Distl, Ute Philipp (University of Hannover) and LUPA

Main contact: Susanne Björnerfeldt, susanne.bjornerfeldt@slu.se