Dermoid sinus (DS)
DS is a congenital disorder where, during embryonic development, the tissues that are to become skin to do not properly separate from the tissues that are to become the nervous system. Dermoid sinuses occur as tubular structures of the skin on the middle of the back, which can penetrate into the spinal canal and become infected, painfully swollen and life threatening for the dog.
Latest Research Update: To map the hair ridge trait in Rhodesian ridgebacks we compared the DNA of 12 ridged dogs to 9 ridgeless dogs and were able to identify a segment of DNA that only occurred in the in the ridged dogs. This segment includes three genes involved in development called fibroblast growth factor (FGF) genes. Through further research we found that the ridge is caused by abnormal duplication of the FGF genes containing region, so that there are more than one copy of each of the three FGF genes. The same mutation is found in both Rhodesian and Thai ridgeback dogs.
See: "In dogs, a shortcut to mapping disease genes"
Hillbertz et al. (2007) Duplication of FGF3, FGF4, FGF19, and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Nature Genetics DOI: 10.1038/ng.2007.4
Breeds needed for our study: Complete
Main collaborators: Göran Andersson (Swedish University of Agricultural Science), Leif Andersson (Uppsala University)
*Note - sample collection at SUAS