Diabetes Genetics Initiative
The Diabetes Genetics Initiative is a collaboration of the Broad Institute of MIT and Harvard, Lund University, and Novartis Institutes for BioMedical Research
The Diabetes Genetics Initiative combines the resources and expertise of the Novartis Institutes for BioMedical Research, the Broad Institute of MIT and Harvard, and Lund University to identify the genetic determinants of type 2 diabetes. This unique collaboration aims to collect and analyze samples from type 2 diabetic patients from nations across the globe, performing whole genome scans to provide a comprehensive view of the DNA sequence variants associated with the disease. This partnership has been forged with the explicit goal of making this vast amount of crucial data available to researchers globally and free of cost, which should lead to a greater understanding of disease biology and speed the development of more effective therapies.
Whole genome scan for type 2 diabetes in a Scandinavian cohort
The goal of this project is to identify inherited risk factors that predispose individuals to type 2 diabetes by performing a whole genome association study in approximately 3,000 individuals from Scandinavia, using the Affymetrix Human Mapping 500K GeneChip®.
Publication in Science: Genome-wide search unearths surprising clues for diabetes and blood triglycerides (04/26/07)
DIAGRAM Consortium: Results from type 2 diabetes meta-analysis
Zeggini E, Scott LJ, Saxena R, Voight BF for the DIAGRAM consortium. Meta-analysis of genome-wide association data and large-scale replication identifies several additional susceptibility loci for type 2 diabetes. Nature Genetics in press.
Family-based linkage scan in three pedigrees with extreme diabetes phenotypes
The goal of this project is to identify chromosomal loci linked to diabetes in three Scandinavian families with clustering of early-onset diabetes using the Affymetrix Human Mapping 500K GeneChip® (10,116 SNPs).
A whole genome admixture scan for type 2 diabetes in African Americans
The goal of this project is to perform a whole genome admixture scan in 1,976 African Americans from the Jackson Heart Study and the Multi-Ethnic Cohort, aiming to localize susceptibility loci for type 2 diabetes.