Selected Recent Publications

Stanley Center publications 2013-2014

Below are selected publications related to key areas of interest to Stanley Center investigators, including: Perspectives on Psychiatric Disease Research, Genetics, Neurobiology, Stem Cell Research, Clinical Research and Tool Development.


Perspectives on Psychiatric Disease Research

McCarroll SA, Feng G, Hyman SE. Genome-scale neurogenetics: methodology and meaning. Nat Neurosci. 2014 Jun 17(6):756-63. [Epub 2014 May 27.]

Hyman SE. Perspective: Revealing molecular secrets. Nature. 2014 Apr 3;508(7494):S20.

Hyman SE. Time for new schizophrenia Rx. Science. 2014 Mar 14;343(6176):1177.

Hyman SE. Revitalizing psychiatric therapeutics. Neuropsychopharmacology 2014 Jan;39(1):220-9. doi: 10.1038/npp.2013.181.

Casey BJ, Craddock N, Cuthbert BN, Hyman SE, Lee FS, Ressler KJ. DSM-5 and RDoC: progress in psychiatry research? Nat Rev Neurosci. 2013 Nov;14(11):810-4. doi: 10.1038/nrn3621.

McCarroll SA and Hyman SE. Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology. Neuron. 2013 Oct 30;80(3):578-87. doi: 10.1016/j.Neuron.2013.10.046.

Plenge RM, Scolnick EM, Altshuler D. Validating therapeutic targets through human genetics. Nat Rev Drug Discov. 2013 Aug;12(8):581-94.

Hyman SE. Psychiatric drug development: diagnosing a crisis. Cerebrum. 2013 Apr 2;2013:5. 


Genetics

Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O'Dushlaine C, Chambert K, Bergen SE, Kahler A, Duncan L, Stahl E, Genovese G, Fernandez E, Collins MO, Komiyama NH, Choudhary JS, Magnusson PKE, Banks E, Shakir K, Garimella K, Fennell T, DePristo M, Grant SGN, Haggarty S, Gabriel S, Scolnick EM, Lander ES, Hultman C, Sullivan PF, McCarroll SA, Sklar P. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014 Jan 22. [Epub ahead of print.]

Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon H, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar, P Owen MJ, Purcell SM, O'Donovan MC. De novo mutations in schizophrenia implicate synaptic networks. Nature. 2014 Jan 22. [Epub ahead of print.]

Duncan LE, Pollastri AR, Smoller JW. Mind the gap: Why many geneticists and psychological scientists have discrepant views about gene-environment interaction (G×E) research. Am Psychol. 2014 Apr;69(3):249-68. 

Duncan LE, Holmans PA, Lee PH, O'Dushlaine CT, Kirby AW, Smoller JW, Öngür D, Cohen BM. Pathway analyses implicate glial cells in schizophrenia. PLoS One. 2014 Feb 24;9(2):e89441. [eCollection 2014.]

Rees E, Kirov G, Sanders A, Walters JT, Chambert KD, Shi J, Szatkiewicz J, O'Dushlaine C, Richards AL, Green EK, Jones I, Davies G, Legge SE, Moran JL, Pato C, Pato M, Genovese G, Levinson D, Duan J, Moy W, Göring HH, Morris D, Cormican P, Kendler KS, O'Neill FA, et al. Evidence that duplications of 22q11.2 protect against schizophrenia. Mol Psychiatry. 2013 Nov 12. [Epub ahead of print.]

Macosko EZ, McCarroll SA. Genetics. Our fallen genomes. Science. 2013 Nov 1;342(6158):564-5. No abstract available.

Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, et al. Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet. 2013 Oct;9(10):e1003864. [Epub 2013 Oct 24.]

Robinson EB, Howrigan D, Yang J, Ripke S, Anttila V, Duncan LE, Jostins L, Barrett JC, Medland SE, Macarthur DG, Breen G, O'Donovan MC, Wray NR, Devlin B, Daly MJ, Visscher PM, Sullivan PF, Neale BM. Response to ‘Predicting the diagnosis of autism spectrum disorder using gene pathway analysis’. Mol Psychiatry. 2013 Oct 22. doi: 10.1038/mp.2013.125. [Epub ahead of print.]

Ripke S, O'Dushlaine C, Chambert K, Moran JL, Kähler A, Akterin S, Bergen S, Collins AL, Crowley J, Fromer M, Kim Y, Lee SH, Magnusson PK, Sanchez N, Stahl EA, Williams S, Wray N, Xia K, Bettella F, Børglum AD, Bulik-Sullivan BK, Cormican P, Craddock N, de Leeuw C, et al. Genome-wide association analysis identifies 14 new risk loci for schizophrenia. Nat Genet. 2013 Oct;45(10):1150-9. doi: 10.1038/ng.2742. [Epub 2013 Aug 25.]

Kirov G, Rees E, Walters JT, Escott-Price V, Georgieva L, Richards AL, Chambert KD, Davies G, Legge SE, Moran JL, McCarroll SA, O'Donovan MC, Owen MJ. The penetrance of copy number variations for schizophrenia and developmental delay. Biol Psychiatry. 2013 Aug 27. doi:pii: S0006-3223(13)00676-8. 10.1016/j.biopsych.2013.07.022. [Epub ahead of print.]

Cross-Disorder Group of the Psychiatric Genomics Consortium. Genetic relationship among five psychiatric disorders estimated from genome-wide SNPS. Nat Genet. 2013 Sep;45(9):984-94. [Epub 2013 Aug 11.]

Solovieff N, Cotsapas C, Lee PH, Purcell SM, Smoller JW. Pleiotropy in complex traits: challenges and strategies. Nat Rev Genet. 2013 Jul;14(7):483-95. [Epub 2013 Jun 11. Review.]

Pato MT, Sobell JL, Medeiros H, Abbott C, Skar B, Buckley PF, Bromet EJ, Escamilla MA, Fanous AH, Lehrer DS, Macciardi F, Malaspina D, McCarroll SA, Marder SR, Moran J, Morley CP, Nicolini H, Perkins DO, Purcell SM, Rapaport MH, Sklar P, Smoller JW, Knowles JA, The Genomic Psychiatry Cohort Consortium, Pato CN. The Genomic Psychiatry Cohort: Partners in discovery. Am J Med Genet B Neuropsychiatr Genet. 2013 May 3.  [Epub ahead of print.]

Genovese G, Handsaker RE, Li H, Altemose N, Lindgren AM, Chambert K, Pasaniuc B, Price AL, Reich D, Morton CC, Pollak MR, Wilson JG, McCarroll SA. Using population admixture to help complete maps of the human genome. Nat Genet. 2013 Apr;45(4):406-14, 414e1-2. [Epub 2013 Feb 24.]

Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. The Lancet. 2013. [Epub: February 28, 2013.]


Neurobiology

Ting JT, Feng G. Recombineering strategies for developing next generation BAC transgenic tools for optogenetics and beyond. Front Behav Neurosci. 2014 Apr 3;8:111. [eCollection 2014.]

Guo ZV, Li N, Huber D, Ophir E, Gutnisky D, Ting JT, Feng G, Svoboda K. Flow of cortical activity underlying a tactile decision in mice. Neuron. 2014 Jan 8;81(1):179-94. doi: 10.1016/j.neuron.2013.10.020. [Epub 2013 Dec 19.]

Burguière E, Monteiro P, Feng G, Graybiel AM. Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science. 2013:340:1243-6.

Pinto L, Goard MJ, Estandian D, Xu M, Kwan AC, Lee S-H, Harrison TC, Feng G, and Dan Y. Fast modulation of visual perception by basal forebrain cholinergic neurons. Nat. Neurosci. 2013:16:1857-63.
 

Ting JT, Feng G. Development of transgenic animals for optogenetic manipulation of mammalian nervous system function: progress and prospects for behavioral neuroscience. Behav Brain Res. 2013 Oct 15;255:3-18. [Epub 2013 Mar 6.]


Stem Cell

Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 2014 Apr 3. doi: 10.1056

Eggan, K. Picking the lock on pluripotency. N Engl J Med. 2013; November 28, 2013;369:2150-2151.


Clinical and Therapeutics

Gilman SE, Ni MY, Dunn EC, Breslau J, McLaughlin KA, Smoller JW, Perlis RH. Contributions of the social environment to first-onset and recurrent mania. Mol Psychiatry. 2014 Apr 22. 

Ostacher MJ, Iosifescu DV, Hay A, Blumenthal SR, Sklar P, Perlis RH. Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association. Bipolar Disord. 2013 Dec 27. doi: 10.1111/bdi.12143. [Epub ahead of print.]

Wang C, Eassalu TE, Barth VN, Mitch CH, Wagner FF, Hong Y, Neelemegam R, Schroeder FA, Holson EB, Haggarty SJ, Hooker JM. Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain. Am J Nucl Med Mol Imaging. 2013 Dec 15:4(1):29-38.

Wagner FF, Weїwer M, Lewis MC, Holson EB. Small molecule inhibitors of zinc-dependent histone deacetylases. Neurotherapeutics. 2013 Oct;10(4):589-604. 

Weïwer M, Lewis MC, Wagner FF, Holson EB. Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia. Future Med Chem. 2013 Sep;5(13):1491-508. doi: 10.4155/fmc.13.141.

Schroeder FA, Chonde DB, Riley MM, Moseley CK, Granda ML, Wilson CM, Wagner FF, Zhang YL, Gale J, Holson EB, Haggarty SJ, Hooker JM. FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors. Neurosci Lett. 2013 Aug 29;550:119-24. [doi: 10.1016/j.neulet.2013.06.016.Epub 2013 Jun 25.]

Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J, Zhao WN, Reis S, Barker DD, Berry-Scott E, Kim SW, Clore EL, Hooker JM, Holson EB, Haggarty SJ, Petryshen TL. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. PLoS One. 2013 Aug 14;8(8):e71323. [eCollection 2013.]

Olson DE, Wagner FF, Kaya T, Gale JP, Aidoud N, Davoine EL, Lazzaro F, Weïwer M, Zhang YL, Holson EB. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013 Jun 13;56(11):4816-20. [Epub 2013 May 29.]


Tool development

Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science. 2014 Jan 3;343(6166):84-7. doi: 10.1126/science. 1247005.