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Selected Publications

Key publications by, or relevant to, the Psychiatric Disease Program

Chemical Biology Relevance (PsychHTS, HDAC2, DISC1, Emerging Genes)

  1. Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, Haggarty SJ: AKT Kinase Activity Is Required for Lithium to Modulate Mood-Related Behaviors in Mice. Neuropsychopharmacology. 2011 Mar 9. [Epub ahead of print]
  2. Duric V, Banasr M, Licznerski P, Schmidt HD, Stockmeier CA, Simen AA, Newton SS, Duman RS: A negative regulator of MAP kinase causes depressive behavior. Nat Med. 2010 Nov;16(11):1328-32.
  3. Mining chemistry for psychiatry. Nat Neurosci 2009, 12(7):809-809.
  4. Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R et al: HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009, 459(7243):55-60.
  5. Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK et al: Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 2009, 136(6):1017-1031.
  6. Insel TR, Scolnick EM: Cure therapeutics and strategic prevention: raising the bar for mental health research. Molecular Psychiatry 2006, 11(1):11-17.
  7. Scolnick EM: Mechanisms of action of medicines for schizophrenia and bipolar illness: status and limitations. Biological Psychiatry 2006, 59(11):1039-1045.
  8. Cottrell JR, Borok E, Horvath TL, Nedivi E: CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors. Neuron 2004, 44(4):677-690.

Genetics

  1. Handsaker RE, Korn JM, Nemesh J, McCarroll SA: Discovery and genotyping of genome structural polymorphism by sequencing on a population scale. Nat Genet. 2011 Mar;43(3):269-76.
  2. 1000 Genomes Project: Mapping copy number variation by population-scale genome sequencing. Nature 2011 Feb 3;470(7332):59-65.
  3. 1000 Genomes Project: A map of human genome variation from population-scale sequencing. Nature 2010 Oct 28;467(7319):1061-73.
  4. Raychaudhuri S, Korn JM, McCarroll SA; International Schizophrenia Consortium, Altshuler D, Sklar P, Purcell S, Daly MJ: Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genet. 2010 Sep 9;6(9).
  5. Craddock N, Sklar P: Genetics of bipolar disorder: successful start to a long journey. Trends in Genetics : TIG 2009, 25(2):99-105.
  6. ISC: Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460(7256):748-752.
  7. Lichtenstein P, Yip BH, Bjork C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM: Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 2009, 373(9659):234-239.
  8. Raychaudhuri S, Plenge RM, Rossin EJ, Ng AC, Purcell SM, Sklar P, Scolnick EM, Xavier RJ, Altshuler D, Daly MJ: Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet 2009, 5(6):e1000534.
  9. Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK et al: Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics 2008, 40(9):1056-1058.
  10. ISC: Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 2008, 455(7210):237-241.
  11. Perlis RH, Purcell S, Fagerness J, Kirby A, Petryshen TL, Fan J, Sklar P: Family-based association study of lithium-related and other candidate genes in bipolar disorder. Arch Gen Psychiatry 2008, 65(1):53-61.
  12. Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A et al: Whole-genome association study of bipolar disorder. Molecular Psychiatry 2008, 13(6):558-569.
  13. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ et al: PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81(3):559-575.
  14. Lichtenstein P, Bjork C, Hultman CM, Scolnick E, Sklar P, Sullivan PF: Recurrence risks for schizophrenia in a Swedish national cohort. Psychol Med 2006, 36(10):1417-1425.