Christina Cuomo is a Group Leader for Fungal Genome Sequencing and Analysis in the Genome Sequencing and Analysis program at the Broad Institute. Christina leads work under the Fungal Genome Initiative, which targets fungi for sequencing that are important human and agricultural pathogens, model systems, and represent the diversity of the fungal kingdom. Fungal sequencing projects develop core genomic resources for important species, and utilize a core set of genomic approaches to better understand phenotypic variation. These may involve comparative genomic analysis of related species to identify species-specific genes important for pathogenesis, transcript sequencing to identify differentially expressed genes, and analysis of polymorphism in fungal populations to correlate variation with phenotypic shifts. This work is highly collaborative with scientists who specialize in each system.
As part of her current work under the Fungal Genome Initiative at the Broad, Christina focuses on analysis of animal and plant pathogens, with the goal of better understanding the genetic basis of pathogenicity. Animal pathogens include three major groups of human pathogens: Candida albicans, Cryptococcus neoformans and the dimorphic fungi. Plant pathogens include the wheat rust fungi (Puccinia sp) which cause current agricultural epidemics and Microbotryum violaceum, a model for studying host shifts, pathogenicity, and sex chromosome evolution.
Christina joined the Whitehead Institute/MIT Center for Genome Research, now part of the Broad Institute, in 2002. For the first year, she co-led the genome closure team, as part of the public Human Genome Project. In 2003, she joined the Fungal Genome Initiative and participates in the analysis of diverse fungal genomes.
Christina received her A.B. in biology from Bryn Mawr College and her Ph.D. in genetics from Harvard University.