Chemical Biology and Therapeutics Science

X-ray co-crystal structure of B52 compound (cyan) binding and inhibiting Cyclophilin D protein
Credit: Aziz Rangwala
X-ray co-crystal structure of B52 compound (cyan) binding and inhibiting Cyclophilin D protein

About

The Chemical Biology and Therapeutics Science (CBTS) Program at the Broad Institute brings together a talented and diverse group of researchers that share a deep commitment to advancing biology and medicine through the use of chemistry and related molecular approaches. Recent advances have expanded the scope of chemical biology and therapeutics science to include: 

  • Breakthroughs in the use of macromolecules to study biology and modify our genomes and proteomes in therapeutically relevant ways.
  • Development of technologies that have transformed how small-molecule and macromolecular structure space can be explored to rapidly identify molecules with remarkable biological properties.
  • Innovative use of chemistry to provide an unprecedented view of previously unseen processes in living systems.
  • Integration of data from multiple technologies and knowledge sources to better understand the roles of small molecules in living systems.