Chemical Biology: Young Group
The Young lab focuses on the generation of novel small molecules to study normal and disease-related biological phenomena. To achieve this goal, we develop new reactions and apply them toward the production of small-molecule libraries. Diversity-oriented synthesis (DOS) is the principle guide for our synthetic activities toward creating a small-molecule screening collection to be tested in a variety of biochemical, phenotypic, cell-based, and whole-organism, high-throughput screens (HTS) at the Broad Institute. We are also the first to introduce the principles of DOS within the area of fragment-based drug discovery (FBDD). Using our DOS-generated fragments and a suite of biophysical assays, we are elucidating binders to challenging disease targets (K-Ras, NF-κB, PTP1B, PCSK9).
Composed of staff scientists, postdoctoral fellows, and graduate and undergraduate students, our group is largely supported by the National Institute of General Medical Sciences (NIGMS) Centers of Excellence in Chemical Methodology and Library Development.