The KCO is led by Broad core faculty member and MIT associate professor Aviv Regev. It has a dedicated team that is pursuing projects in a variety of cell types together with collaborators from throughout the Broad community and beyond.
The KCO pursues three major goals:
• Develop and deploy experimental and computational approaches for systematically defining cellular circuits. These include capabilities – in the KCO and across the Broad’s Platforms – for measuring all cellular components and their connections, reconstructing circuit models, and producing and delivering perturbing agents to cells.
• Execute Cell Observatory Projects, to reconstruct circuits in mammalian cells.
Collaborative Projects to tackle only specific parts of the circuitry, learning how to overcome key challenges and address key questions.
• Broad Institute-ISF Partnership for Cell Circuit Research, a joint program with the Israel Science Foundation to tackle major challenges in cell circuitry, that includes collaborative projects, a postdoctoral training program, and an annual symposium for Israeli and Broad scientists.