The Observatory is led by Broad core faculty member and MIT associate professor Aviv Regev. It has a dedicated team that is pursuing projects in a variety of cell types together with collaborators from throughout the Broad community and beyond.
The Observatory pursues three major goals:
• Develop and deploy experimental and computational approaches for systematically defining cellular circuits. These include capabilities – in the Observatory and across the Broad’s Platforms – for measuring all cellular components and their connections, reconstructing circuit models, and producing and delivering perturbing agents to cells.
• Execute Cell Observatory Projects, to reconstruct circuits in mammalian cells.
Collaborative Projects to tackle only specific parts of the circuitry, learning how to overcome key challenges and address key questions.
These projects will be undertaken in collaboration with scientists in the Broad community, drawing on their deep expertise in a biological system. Approximately four collaborative projects will be selected each year.
• A Broad Institute – Israel Partnership for Circuit Research, a joint program with the Israel Science Foundation to tackle major challenges in cell circuitry, that includes collaborative projects, a postdoctoral training program, and an annual symposium for Israeli and Broad scientists.