BIPDeC - Probe Development Pipeline
The Broad Institute is a Probe Development Center within the MLPCN (Broad Institute Probe Development Center [BIPDeC]) and we perform probe development projects accepted by the NIH and assigned to our Center. While project selection is ultimately determined by the grant review committee at the NIH, the Broad Institute Application Review Committee will endorse some NIH grant application projects for acceptance by the MLPCN. Most, if not all, projects endorsed by our Committee will be performed at BIPDeC.
This page provides the resources necessary to learn about and apply for BIPDeC endorsement of NIH R03 applications and Fast Track applications.
All projects accepted by the NIH receive funding for screening and/or chemistry optimization via either an NIH R01/ R21 mechanism or a Fast Track mechanism.
To apply for a letter of endorsement from BIPDeC, it is important that we learn about your project as early as possible. This is accomplished by contacting Dr. Jim Spoonamore who manages our Outreach Lab. Dr. Spoonamore has mentored many scientists through the grant application process and manages a facility that has helped researchers perform pilot screens and generate the data required for successful R03 applications. He is also well versed in the Fast Track application process and has successfully guided many investigators into our Center using this mechanism.
As outlined by the NIH, all projects accepted for screening by the NIH through the BIPDeC will be subject to the NIH MLPCN Project Team Position on Data Sharing and IP in the MLPCN Program.
R01/ R21 Links
- PAR-12-058 Solicitation of Assays for High Throughput Screening (HTS) to Discover Chemical Probes (R01)
- PAR-12-059 Solicitation of Assays for High Throughput Screening (HTS) to Discover Chemical Probes (R21)
- PAR-12-060 Solicitation of Validated Hits for the Discovery of in vivo Chemical Probes (R01)
If the development of a screen has been listed as a goal in a peer-reviewed grant, it may be possible to access the MLPCN through the Fast Track mechanism. These applications are reviewed by the NIH on a monthly basis. For more information, please click the Fast Track link above to review the requirements and contact us as well for further guidance.
If you have any questions, please email BIPDeC and your request will be directed to the relevant contact.