Images of cells, when suitably stained, contain a vast amount of information about cellular state and are generated by the hundreds of thousands in experiments to determine the functions of genes and to identify useful chemicals for research and for therapeutics.
The Broad's Imaging Platform is a world leader in developing advanced methods to quantify and mine the rich information present in cellular images to yield biological discoveries. The integration of data resulting from systems biology/functional genomics studies and image-based screens from the Imaging Platform generates novel biological hypotheses. Additionally, we develop open-source software tools and help biologists to apply them to significant questions in the life sciences. The platform's major activities include:
We develop advanced image analysis methods, with an emphasis on high-throughput screening. Many cellular phenotypes of interest to researchers require custom image analysis methods. We develop and test new algorithms and implement them into an easy-to-use, open-source software package called CellProfiler.
We develop advanced data mining methods, with an emphasis on image-based screening. Image-based screens generate extremely large, multidimensional data sets because images contain rich, quantifiable information for every individual cell. We develop and test new methods and procedures to statistically analyze and mine this data and implement them into an easy-to-use, open-source software package called CellProfiler Analyst.
Broad Bioimage Benchmark Collection
In order to help computer scientists develop and validate new imaging analysis methods, we provide the Broad Bioimage Benchmark Collection, a collection of image sets, ground truth, and benchmarking methodologies for biological images.