Publications - Broad NCRR Center for Genotyping and Analysis

The Broad Institute Center for Genotyping and Analysis, and its founding grant (U54 RR020278) from the National Center for Research Resources, have through their laboratory and analytic resources for SNP genotyping enabled the generation of data and results supporting the following scientific publications.

Quick link to year of publication: 2006 | 2007 | 2008 | 2009 | 2010 | 2011

Authors listed in green received a genotyping subsidy from the NCRR for some or all of the work described in the publication.

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2011

Chung, S.A., Taylor, K.E., Graham, R.R., Nititham, J., Lee, A.T., Ortmann, W.A., Jacob, C.O., Alarcon-Riquelme, M.E., Tsao, B.P., Harley, J.B., Gaffney, P.M., Moser, K.L., Petri, M., Demirci, F.Y., Kamboh, M.I., Manzi, S., Gregersen, P.K., Langefeld, C.D., Behrens, T.W., and Criswell, L.A. (2011). Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. PLoS Genet 7, e1001323.

Haataja, R., Karjalainen, M.K., Luukkonen, A., Teramo, K., Puttonen, H., Ojaniemi, M., Varilo, T., Chaudhari, B.P., Plunkett, J., Murray, J.C., McCarroll, S.A., Peltonen, L., Muglia, L.J., Palotie, A., and Hallman, M. (2011). Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis. PLoS Genet 7, e1001293.

Levinson, D.F., Duan, J., Oh, S., Wang, K., Sanders, A.R., Shi, J., Zhang, N., Mowry, B.J., Olincy, A., Amin, F., Cloninger, C.R., Silverman, J.M., Buccola, N.G., Byerley, W.F., Black, D.W., Kendler, K.S., Freedman, R., Dudbridge, F., Pe'er, I., Hakonarson, H., Bergen, S.E., Fanous, A.H., Holmans, P.A., and Gejman, P.V. (2011). Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. Am J Psychiatry 168, 302-316.

Penney, K.L., Schumacher, F.R., Kraft, P., Mucci, L.A., Sesso, H.D., Ma, J., Niu, Y., Cheong, J.K., Hunter, D.J., Stampfer, M.J., and Hsu, S.I. (2011). Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels. Carcinogenesis.

Reilly, M.P., Li, M., He, J., Ferguson, J.F., Stylianou, I.M., Mehta, N.N., Burnett, M.S., Devaney, J.M., Knouff, C.W., Thompson, J.R., Horne, B.D., Stewart, A.F., Assimes, T.L., Wild, P.S., Allayee, H., Nitschke, P.L., Patel, R.S., Martinelli, N., Girelli, D., Quyyumi, A.A., Anderson, J.L., Erdmann, J., Hall, A.S., Schunkert, H., Quertermous, T., Blankenberg, S., Hazen, S.L., Roberts, R., Kathiresan, S., Samani, N.J., Epstein, S.E., and Rader, D.J. (2011). Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet 377, 383-392.

Ruiz-Narvaez, E.A., Rosenberg, L., Wise, L.A., Reich, D., and Palmer, J.R. (2011). Validation of a small set of ancestral informative markers for control of population admixture in African Americans. Am J Epidemiol 173, 587-592.

Shi, J., Potash, J.B., Knowles, J.A., Weissman, M.M., Coryell, W., Scheftner, W.A., Lawson, W.B., Depaulo, J.R., Jr., Gejman, P.V., Sanders, A.R., Johnson, J.K., Adams, P., Chaudhury, S., Jancic, D., Evgrafov, O., Zvinyatskovskiy, A., Ertman, N., Gladis, M., Neimanas, K., Goodell, M., Hale, N., Ney, N., Verma, R., Mirel, D., Holmans, P., and Levinson, D.F. (2011). Genome-wide association study of recurrent early-onset major depressive disorder. Mol Psychiatry 16, 193-201.

Shyn, S.I., Shi, J., Kraft, J.B., Potash, J.B., Knowles, J.A., Weissman, M.M., Garriock, H.A., Yokoyama, J.S., Mcgrath, P.J., Peters, E.J., Scheftner, W.A., Coryell, W., Lawson, W.B., Jancic, D., Gejman, P.V., Sanders, A.R., Holmans, P., Slager, S.L., Levinson, D.F., and Hamilton, S.P. (2011). Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. Mol Psychiatry 16, 202-215.

Taylor, K.E., Chung, S.A., Graham, R.R., Ortmann, W.A., Lee, A.T., Langefeld, C.D., Jacob, C.O., Kamboh, M.I., Alarcon-Riquelme, M.E., Tsao, B.P., Moser, K.L., Gaffney, P.M., Harley, J.B., Petri, M., Manzi, S., Gregersen, P.K., Behrens, T.W., and Criswell, L.A. (2011). Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS Genet 7, e1001311.

Wu, I.C., Zhao, Y., Zhai, R., Liu, G., Ter-Minassian, M., Asomaning, K., Su, L., Liu, C.Y., Chen, F., Kulke, M.H., Heist, R.S., and Christiani, D.C. (2011). Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Neoplasia 13, 386-392.

Zhang, M., Qureshi, A.A., Guo, Q., and Han, J. (2011). Genetic variation in DNA repair pathway genes and melanoma risk. DNA Repair (Amst) 10, 111-116.

 

2010

Anderson, C.D., Biffi, A., Rost, N.S., Cortellini, L., Furie, K.L., and Rosand, J. (2010). Chromosome 9p21 in ischemic stroke: population structure and meta-analysis. Stroke 41, 1123-1131.

Biffi, A., Anderson, C.D., Nalls, M.A., Rahman, R., Sonni, A., Cortellini, L., Rost, N.S., Matarin, M., Hernandez, D.G., Plourde, A., De Bakker, P.I., Ross, O.A., Greenberg, S.M., Furie, K.L., Meschia, J.F., Singleton, A.B., Saxena, R., and Rosand, J. (2010). Principal-component analysis for assessment of population stratification in mitochondrial medical genetics. Am J Hum Genet 86, 904-917.

Cree, B.A., Rioux, J.D., McCauley, J.L., Gourraud, P.A., Goyette, P., McElroy, J., De Jager, P., Santaniello, A., Vyse, T.J., Gregersen, P.K., Mirel, D., Hafler, D.A., Haines, J.L., Pericak-Vance, M.A., Compston, A., Sawcer, S.J., Oksenberg, J.R., and Hauser, S.L. (2010). A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. PLoS One 5, e11296.

Fallin, M.D., Szymanski, M., Wang, R., Gherman, A., Bassett, S.S., and Avramopoulos, D. (2010). Fine mapping of the chromosome 10q11-q21 linkage region in Alzheimer's disease cases and controls. Neurogenetics 11, 335-348.

Glessner, J.T., Wang, K., Sleiman, P.M., Zhang, H., Kim, C.E., Flory, J.H., Bradfield, J.P., Imielinski, M., Frackelton, E.C., Qiu, H., Mentch, F., Grant, S.F., and Hakonarson, H. (2010). Duplication of the SLIT3 locus on 5q35.1 predisposes to major depressive disorder. PLoS One 5, e15463.

Gupta, R., Ejebe, K., Butler, J., Lettre, G., Lyon, H., Guiducci, C., Wilks, R., Bennett, F., Forrester, T., Tayo, B., Musunuru, K., Hirschhorn, J., Kathiresan, S., Cooper, R.S., and McKenzie, C.A. (2010). Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica. Hum Genet 128, 557-561.

Jakkula, E., Leppa, V., Sulonen, A.M., Varilo, T., Kallio, S., Kemppinen, A., Purcell, S., Koivisto, K., Tienari, P., Sumelahti, M.L., Elovaara, I., Pirttila, T., Reunanen, M., Aromaa, A., Oturai, A.B., Sondergaard, H.B., Harbo, H.F., Mero, I.L., Gabriel, S.B., Mirel, D.B., Hauser, S.L., Kappos, L., Polman, C., De Jager, P.L., Hafler, D.A., Daly, M.J., Palotie, A., Saarela, J., and Peltonen, L. (2010). Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am J Hum Genet 86, 285-291.

Johansen, C.T., Wang, J., Lanktree, M.B., Cao, H., McIntyre, A.D., Ban, M.R., Martins, R.A., Kennedy, B.A., Hassell, R.G., Visser, M.E., Schwartz, S.M., Voight, B.F., Elosua, R., Salomaa, V., O'Donnell, C.J., Dallinga-Thie, G.M., Anand, S.S., Yusuf, S., Huff, M.W., Kathiresan, S., and Hegele, R.A. (2010). Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet 42, 684-687.

Kang, S.J., Chiang, C.W., Palmer, C.D., Tayo, B.O., Lettre, G., Butler, J.L., Hackett, R., Adeyemo, A.A., Guiducci, C., Berzins, I., Nguyen, T.T., Feng, T., Luke, A., Shriner, D., Ardlie, K., Rotimi, C., Wilks, R., Forrester, T., McKenzie, C.A., Lyon, H.N., Cooper, R.S., Zhu, X., and Hirschhorn, J.N. (2010). Genome-wide association of anthropometric traits in African- and African-derived populations. Hum Mol Genet 19, 2725-2738.

Kumar, R., Seibold, M.A., Aldrich, M.C., Williams, L.K., Reiner, A.P., Colangelo, L., Galanter, J., Gignoux, C., Hu, D., Sen, S., Choudhry, S., Peterson, E.L., Rodriguez-Santana, J., Rodriguez-Cintron, W., Nalls, M.A., Leak, T.S., O'Meara, E., Meibohm, B., Kritchevsky, S.B., Li, R., Harris, T.B., Nickerson, D.A., Fornage, M., Enright, P., Ziv, E., Smith, L.J., Liu, K., and Burchard, E.G. (2010). Genetic ancestry in lung-function predictions. N Engl J Med 363, 321-330.

Liu, C.Y., Wu, M.C., Chen, F., Ter-Minassian, M., Asomaning, K., Zhai, R., Wang, Z., Su, L., Heist, R.S., Kulke, M.H., Lin, X., Liu, G., and Christiani, D.C. (2010). A Large-scale genetic association study of esophageal adenocarcinoma risk. Carcinogenesis 31, 1259-1263.

Nalls, M., et al. (2010). Failure to validate association between 12p13 variants and ischemic stroke. N Engl J Med 362, 1547-1550.

Neale, B.M., Fagerness, J., Reynolds, R., Sobrin, L., Parker, M., Raychaudhuri, S., Tan, P.L., Oh, E.C., Merriam, J.E., Souied, E., Bernstein, P.S., Li, B., Frederick, J.M., Zhang, K., Brantley, M.A., Jr., Lee, A.Y., Zack, D.J., Campochiaro, B., Campochiaro, P., Ripke, S., Smith, R.T., Barile, G.R., Katsanis, N., Allikmets, R., Daly, M.J., and Seddon, J.M. (2010). Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A 107, 7395-7400.

Peloso, G.M., Demissie, S., Collins, D., Mirel, D.B., Gabriel, S.B., Cupples, L.A., Robins, S.J., Schaefer, E.J., and Brousseau, M.E. (2010). Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. J Lipid Res.

Penney, K.L., Pyne, S., Schumacher, F.R., Sinnott, J.A., Mucci, L.A., Kraft, P.L., Ma, J., Oh, W.K., Kurth, T., Kantoff, P.W., Giovannucci, E.L., Stampfer, M.J., Hunter, D.J., and Freedman, M.L. (2010). Genome-wide association study of prostate cancer mortality. Cancer Epidemiol Biomarkers Prev 19, 2869-2876.

Ruiz-Narvaez, E.A., Rosenberg, L., Cozier, Y.C., Cupples, L.A., Adams-Campbell, L.L., and Palmer, J.R. (2010). Polymorphisms in the TOX3/LOC643714 locus and risk of breast cancer in African-American women. Cancer Epidemiol Biomarkers Prev 19, 1320-1327.

Ruiz-Narvaez, E.A., Rosenberg, L., Rotimi, C.N., Cupples, L.A., Boggs, D.A., Adeyemo, A., Cozier, Y.C., Adams-Campbell, L.L., and Palmer, J.R. (2010). Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women's Health Study. Breast Cancer Res Treat 123, 525-530.

Sobrin, L., Maller, J.B., Neale, B.M., Reynolds, R.C., Fagerness, J.A., Daly, M.J., and Seddon, J.M. (2010). Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: a novel analytic approach. Eur J Hum Genet 18, 496-501.

Stahl, E.A., Raychaudhuri, S., Remmers, E.F., Xie, G., Eyre, S., Thomson, B.P., Li, Y., Kurreeman, F.A., Zhernakova, A., Hinks, A., Guiducci, C., Chen, R., Alfredsson, L., Amos, C.I., Ardlie, K.G., Barton, A., Bowes, J., Brouwer, E., Burtt, N.P., Catanese, J.J., Coblyn, J., Coenen, M.J., Costenbader, K.H., Criswell, L.A., Crusius, J.B., Cui, J., De Bakker, P.I., De Jager, P.L., Ding, B., Emery, P., Flynn, E., Harrison, P., Hocking, L.J., Huizinga, T.W., Kastner, D.L., Ke, X., Lee, A.T., Liu, X., Martin, P., Morgan, A.W., Padyukov, L., Posthumus, M.D., Radstake, T.R., Reid, D.M., Seielstad, M., Seldin, M.F., Shadick, N.A., Steer, S., Tak, P.P., Thomson, W., Van Der Helm-Van Mil, A.H., Van Der Horst-Bruinsma, I.E., Van Der Schoot, C.E., Van Riel, P.L., Weinblatt, M.E., Wilson, A.G., Wolbink, G.J., Wordsworth, B.P., Wijmenga, C., Karlson, E.W., Toes, R.E., De Vries, N., Begovich, A.B., Worthington, J., Siminovitch, K.A., Gregersen, P.K., Klareskog, L., and Plenge, R.M. (2010). Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet 42, 508-514.

Szymanski, M., Wang, R., Fallin, M.D., Bassett, S.S., and Avramopoulos, D. (2010). Neuroglobin and Alzheimer's dementia: genetic association and gene expression changes. Neurobiol Aging 31, 1835-1842.

Teslovich, T.M., Musunuru, K., Smith, A.V., Edmondson, A.C., Stylianou, I.M., Koseki, M., Pirruccello, J.P., Ripatti, S., Chasman, D.I., Willer, C.J., Johansen, C.T., Fouchier, S.W., Isaacs, A., Peloso, G.M., Barbalic, M., Ricketts, S.L., Bis, J.C., Aulchenko, Y.S., Thorleifsson, G., Feitosa, M.F., Chambers, J., Orho-Melander, M., Melander, O., Johnson, T., Li, X., Guo, X., Li, M., Shin Cho, Y., Jin Go, M., Jin Kim, Y., Lee, J.Y., Park, T., Kim, K., Sim, X., Twee-Hee Ong, R., Croteau-Chonka, D.C., Lange, L.A., Smith, J.D., Song, K., Hua Zhao, J., Yuan, X., Luan, J., Lamina, C., Ziegler, A., Zhang, W., Zee, R.Y., Wright, A.F., Witteman, J.C., Wilson, J.F., Willemsen, G., Wichmann, H.E., Whitfield, J.B., Waterworth, D.M., Wareham, N.J., Waeber, G., Vollenweider, P., Voight, B.F., Vitart, V., Uitterlinden, A.G., Uda, M., Tuomilehto, J., Thompson, J.R., Tanaka, T., Surakka, I., Stringham, H.M., Spector, T.D., Soranzo, N., Smit, J.H., Sinisalo, J., Silander, K., Sijbrands, E.J., Scuteri, A., Scott, J., Schlessinger, D., Sanna, S., Salomaa, V., Saharinen, J., Sabatti, C., Ruokonen, A., Rudan, I., Rose, L.M., Roberts, R., Rieder, M., Psaty, B.M., Pramstaller, P.P., Pichler, I., Perola, M., Penninx, B.W., Pedersen, N.L., Pattaro, C., Parker, A.N., Pare, G., Oostra, B.A., O'Donnell, C.J., Nieminen, M.S., Nickerson, D.A., Montgomery, G.W., Meitinger, T., McPherson, R., McCarthy, M.I., McArdle, W., Masson, D., Martin, N.G., Marroni, F., Mangino, M., Magnusson, P.K., Lucas, G., Luben, R., Loos, R.J., Lokki, M.L., Lettre, G., Langenberg, C., Launer, L.J., Lakatta, E.G., Laaksonen, R., Kyvik, K.O., Kronenberg, F., Konig, I.R., Khaw, K.T., Kaprio, J., Kaplan, L.M., Johansson, A., Jarvelin, M.R., Cecile, J.W.J.A., Ingelsson, E., Igl, W., Kees Hovingh, G., Hottenga, J.J., Hofman, A., Hicks, A.A., Hengstenberg, C., Heid, I.M., Hayward, C., Havulinna, A.S., Hastie, N.D., Harris, T.B., Haritunians, T., Hall, A.S., Gyllensten, U., Guiducci, C., Groop, L.C., Gonzalez, E., Gieger, C., Freimer, N.B., Ferrucci, L., Erdmann, J., Elliott, P., Ejebe, K.G., Doring, A., Dominiczak, A.F., Demissie, S., Deloukas, P., De Geus, E.J., De Faire, U., Crawford, G., Collins, F.S., Chen, Y.D., Caulfield, M.J., Campbell, H., Burtt, N.P., Bonnycastle, L.L., Boomsma, D.I., Boekholdt, S.M., Bergman, R.N., Barroso, I., Bandinelli, S., Ballantyne, C.M., Assimes, T.L., Quertermous, T., Altshuler, D., Seielstad, M., Wong, T.Y., Tai, E.S., Feranil, A.B., Kuzawa, C.W., Adair, L.S., Taylor, H.A., Jr., Borecki, I.B., Gabriel, S.B., Wilson, J.G., Holm, H., Thorsteinsdottir, U., Gudnason, V., Krauss, R.M., Mohlke, K.L., Ordovas, J.M., Munroe, P.B., Kooner, J.S., Tall, A.R., Hegele, R.A., Kastelein, J.J., Schadt, E.E., Rotter, J.I., Boerwinkle, E., Strachan, D.P., Mooser, V., Stefansson, K., Reilly, M.P., Samani, N.J., Schunkert, H., Cupples, L.A., Sandhu, M.S., Ridker, P.M., Rader, D.J., Van Duijn, C.M., Peltonen, L., Abecasis, G.R., Boehnke, M., and Kathiresan, S. (2010). Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713.

 

2009

Bergholdt, R., Brorsson, C., Boehm, B., Morahan, G., and Pociot, F. (2009). No association of the IRS1 and PAX4 genes with type I diabetes. Genes Immun 10 Suppl 1, S49-53.

Brown, W.M., Pierce, J.J., Hilner, J.E., Perdue, L.H., Lohman, K., Lu, L., De Bakker, P.I., Irenze, K., Ziaugra, L., and Mirel, D.B. (2009). Overview of the Rapid Response data. Genes Immun 10 Suppl 1, S5-S15.

Cheng, C. Y., Kao, W. H., Patterson, N., Tandon, A., Haiman, C. A., Harris, T. B., Xing, C., John, E. M., Ambrosone, C. B., Brancati, F. L., Coresh, J., Press, M. F., Parekh, R. S., Klag, M. J., Meoni, L. A., Hsueh, W. C., Fejerman, L., Pawlikowska, L., Freedman, M. L., Jandorf, L. H., Bandera, E. V., Ciupak, G. L., Nalls, M. A., Akylbekova, E. L., Orwoll, E. S., Leak, T. S., Miljkovic, I., Li, R., Ursin, G., Bernstein, L., Ardlie, K., Taylor, H. A., Boerwinkle, E., Zmuda, J. M., Henderson, B. E., Wilson, J. G. and Reich, D. (2009). Admixture mapping of 15,280 African Americans identifies obesity susceptibility Loci on chromosomes 5 and X. PLoS Genet 5(5): e1000490.

Cooper, J.D., Walker, N.M., Healy, B.C., Smyth, D.J., Downes, K., and Todd, J.A. (2009). Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1. Genes Immun 10 Suppl 1, S95-120. 

Cooper, J.D., Walker, N.M., Smyth, D.J., Downes, K., Healy, B.C., and Todd, J.A. (2009). Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families. Genes Immun 10 Suppl 1, S85-94.

Cui, J., Taylor, K. E., Destefano, A. L., Criswell, L. A., Izmailova, E. S., Parker, A., Roubenoff, R., Plenge, R. M., Weinblatt, M. E., Shadick, N.A. and Karlson, E. W. (2009). Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis. Mol Med 15(5-6): 136-43.

Deo, R.C., Reich, D., Tandon, A., Akylbekova, E., Patterson, N., Waliszewska, A., Kathiresan, S., Sarpong, D., Taylor, H.A., Jr., and Wilson, J.G. (2009). Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. PLoS Genet 5, e1000342.

Edmondson, A. C., Brown, R. J., Kathiresan, S., Cupples, L. A., Demissie, S., Manning, A. K., Jensen, M. K., Rimm, E. B., Wang, J., Rodrigues, A., Bamba, V., Khetarpal, S. A., Wolfe, M. L., Derohannessian, S., Li, M., Reilly, M. P., Aberle, J., Evans, D., Hegele, R. A. and Rader, D. J. (2009). Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. J Clin Invest 119(4): 1042-50.

Erdmann, J., Grosshennig, A., Braund, P. S., Konig, I. R., Hengstenberg, C., Hall, A. S., Linsel-Nitschke, P., Kathiresan, S., Wright, B., Tregouet, D. A., Cambien, F., Bruse, P., Aherrahrou, Z., Wagner, A. K., Stark, K., Schwartz, S. M., Salomaa, V., Elosua, R., Melander, O., Voight, B. F., O'Donnell, C. J., Peltonen, L., Siscovick, D. S., Altshuler, D., Merlini, P. A., Peyvandi, F., Bernardinelli, L., Ardissino, D., Schillert, A., Blankenberg, S., Zeller, T., Wild, P., Schwarz, D. F., Tiret, L., Perret, C., Schreiber, S., El Mokhtari, N. E., Schafer, A., Marz, W., Renner, W., Bugert, P., Kluter, H., Schrezenmeir, J., Rubin, D., Ball, S. G., Balmforth, A. J., Wichmann, H. E., Meitinger, T., Fischer, M., Meisinger, C., Baumert, J., Peters, A., Ouwehand, W. H., Deloukas, P., Thompson, J. R., Ziegler, A., Samani, N. J. and Schunkert, H. (2009). New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet 41(3): 280-2.

Erlich, H.A., Lohman, K., Mack, S.J., Valdes, A.M., Julier, C., Mirel, D., Noble, J.A., Morahan, G.E., and Rich, S.S. (2009). Association analysis of SNPs in the IL4R locus with type I diabetes. Genes Immun 10 Suppl 1, S33-41.

Erlich, H.A., Valdes, A.M., Julier, C., Mirel, D., and Noble, J.A. (2009). Evidence for association of the TCF7 locus with type I diabetes. Genes Immun 10 Suppl 1, S54-59. 

Everett, E.T., Yan, D., Weaver, M., Liu, L., Foroud, T., and Martinez-Mier, E.A. (2009). Detection of dental fluorosis-associated quantitative trait Loci on mouse chromosomes 2 and 11. Cells Tissues Organs 189, 212-218.

Fagerness, J. A., Maller, J. B., Neale, B. M., Reynolds, R. C., Daly, M. J. and Seddon, J. M. (2009). Variation near complement factor I is associated with risk of advanced AMD. Eur J Hum Genet 17(1): 100-4.

Greenway, S. C., Pereira, A. C., Lin, J. C., DePalma, S. R., Israel, S. J., Mesquita, S. M., Ergul, E., Conta, J. H., Korn, J. M., McCarroll, S. A., Gorham, J. M., Gabriel, S., Altshuler, D. M., Quintanilla-Dieck, M. de L., Artunduaga, M. A., Eavey, R. D., Plenge, R. M., Shadick, N. A., Weinblatt, M. E., De Jager, P. L., Hafler, D. A., Breitbart, R. E., Seidman, J. G. and Seidman, C. E. (2009). De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nat Genet 41(8): 931-5.

Han, J., Haiman, C., Niu, T., Guo, Q., Cox, D.G., Willett, W.C., Hankinson, S.E., and Hunter, D.J. (2009). Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk. Breast Cancer Res Treat 115, 613-622.

Hong, X., Zhou, H., Tsai, H.J., Wang, X., Liu, X., Wang, B., Xu, X., and Xu, X. (2009). Cysteinyl leukotriene receptor 1 gene variation and risk of asthma. Eur Respir J 33, 42-48.

Howson, J.M., Walker, N.M., Smyth, D.J., and Todd, J.A. (2009). Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families. Genes Immun 10 Suppl 1, S74-84.

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Buac, K., Watkins-Chow, D.E., Loftus, S.K., Larson, D.M., Incao, A., Gibney, G., and Pavan, W.J. (2008). A sox10 expression screen identifies an amino Acid essential for erbb3 function. PLoS Genet 4, e1000177.

Cunninghame Graham, D. S., Graham, R. R., Manku, H., Wong, A. K., Whittaker, J. C., Gaffney, P. M., Moser, K. L., Rioux, J. D., Altshuler, D., Behrens, T. W. and Vyse, T. J. (2008). Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nat Genet 40(1): 83-9.

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Gayan, J., Brocklebank, D., Andresen, J.M., Alkorta-Aranburu, G., Zameel Cader, M., Roberts, S.A., Cherny, S.S., Wexler, N.S., Cardon, L.R., and Housman, D.E. (2008). Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds. Genet Epidemiol. 32, 445-53.

Graham, D.S., Graham, R.R., Manku, H., Wong, A.K., Whittaker, J.C., Gaffney, P.M., Moser, K.L., Rioux, J.D., Altshuler, D., Behrens, T.W., and Vyse, T.J. (2008). Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nat Genet 40, 83-89.

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Limdi, N.A., Arnett, D.K., Goldstein, J.A., Beasley, T.M., McGwin, G., Adler, B.K., and Acton, R.T. (2008). Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans. Pharmacogenomics 9, 511-526.

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Neafsey, D. E., Schaffner, S. F., Volkman, S. K., Park, D., Montgomery, P., Milner, D. A., Jr., Lukens, A., Rosen, D., Daniels, R., Houde, N., Cortese, J. F., Tyndall, E., Gates, C., Stange-Thomann, N., Sarr, O., Ndiaye, D., Ndir, O., Mboup, S., Ferreira, M. U., Moraes, S. do L., Dash, A. P., Chitnis, C. E., Wiegand, R. C., Hartl, D. L., Birren, B. W., Lander, E. S., Sabeti, P. C. and Wirth, D. F. (2008). Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biol 9(12): R171.

Perlis, R.H., Purcell, S., Fagerness, J., Kirby, A., Petryshen, T.L., Fan, J., and Sklar, P. (2008). Family-based association study of lithium-related and other candidate genes in bipolar disorder. Arch Gen Psychiatry 65, 53-61.

Price, A.L., Butler, J., Patterson, N., Capelli, C., Pascali, V.L., Scarnicci, F., Ruiz-Linares, A., Groop, L., Saetta, A.A., Korkolopoulou, P., Seligsohn, U., Waliszewska, A., Schirmer, C., Ardlie, K., Ramos, A., Nemesh, J., Arbeitman, L., Goldstein, D.B., Reich, D., and Hirschhorn, J.N. (2008). Discerning the Ancestry of European Americans in Genetic Association Studies. PLoS Genet 4, e236.

Raychaudhuri, S., Remmers, E.F., Lee, A.T., Hackett, R., Guiducci, C., Burtt, N.P., Gianniny, L., Korman, B.D., Padyukov, L., Kurreeman, F.A., Chang, M., Catanese, J.J., Ding, B., Wong, S., van der Helm-van Mil, A.H., Neale, B.M., Coblyn, J., Cui, J., Tak, P.P., Wolbink, G.J., Crusius, J.B., van der Horst-Bruinsma, I.E., Criswell, L.A., Amos, C.I., Seldin, M.F., Kastner, D.L., Ardlie, K.G., Alfredsson, L., Costenbader, K.H., Altshuler, D., Huizinga, T.W., Shadick, N.A., Weinblatt, M.E., de Vries, N., Worthington, J., Seielstad, M., Toes, R.E., Karlson, E.W., Begovich, A.B., Klareskog, L., Gregersen, P.K., Daly, M.J., and Plenge, R.M. (2008). Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet 40, 1216-1223.

Rhodes, B., Meek, J., Whittaker, J.C., and Vyse, T.J. (2008). Quantification of the genetic component of basal C-reactive protein expression in SLE nuclear families. Ann Hum Genet 72, 611-620.

Ross, R.W., Oh, W.K., Xie, W., Pomerantz, M., Nakabayashi, M., Sartor, O., Taplin, M.E., Regan, M.M., Kantoff, P.W., and Freedman, M. (2008). Inherited variation in the androgen pathway is associated with the efficacy of androgen-deprivation therapy in men with prostate cancer. J Clin Oncol 26, 842-847.

Rubio, J.P., Stankovich, J., Field, J., Tubridy, N., Marriott, M., Chapman, C., Bahlo, M., Perera, D., Johnson, L.J., Tait, B.D., Varney, M.D., Speed, T.P., Taylor, B.V., Foote, S.J., Butzkueven, H., and Kilpatrick, T.J. (2008). Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians. Genes Immun. 9, 624-630.

Tiedt, R., Hao-Shen, H., Sobas, M.A., Looser, R., Dirnhofer, S., Schwaller, J., and Skoda, R.C. (2008). Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood 111, 3931-3940.

Taconic | Newsroom | News | 2008 | C57BL/6 and Apoe mouse strains resumed.

2007

Fernando, M.M., Stevens, C.R., Sabeti, P.C., Walsh, E.C., McWhinnie, A.J., Shah, A., Green, T., Rioux, J.D., and Vyse, T.J. (2007). Identification of two independent risk factors for lupus within the MHC in United Kingdom families. PLoS Genet 3, e192.

Florez, J.C., Manning, A.K., Dupuis, J., McAteer, J., Irenze, K., Gianniny, L., Mirel, D.B., Fox, C.S., Cupples, L.A., and Meigs, J.B. (2007). A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets. Diabetes 56, 3063-3074.

Francis, P.J., George, S., Schultz, D.W., Rosner, B., Hamon, S., Ott, J., Weleber, R.G., Klein, M.L., and Seddon, J.M. (2007). The LOC387715 gene, smoking, body mass index, environmental associations with advanced age-related macular degeneration. Hum Hered 63, 212-218.

Hafler, D.A., Compston, A., Sawcer, S., Lander, E.S., Daly, M.J., De Jager, P.L., de Bakker, P.I., Gabriel, S.B., Mirel, D.B., Ivinson, A.J., Pericak-Vance, M.A., Gregory, S.G., Rioux, J.D., McCauley, J.L., Haines, J.L., Barcellos, L.F., Cree, B., Oksenberg, J.R., and Hauser, S.L. (2007). Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 357, 851-862.

Kim, K., Lerou, P., Yabuuchi, A., Lengerke, C., Ng, K., West, J., Kirby, A., Daly, M. J., and Daley, G. Q. (2007). Histocompatible embryonic stem cells by parthenogenesis. Science 315, 482-486.

Kim, K., Ng, K., Rugg-Gunn, P.J., Shieh, J.-H., Kirak, O., Jaenisch, R., Wakayama, T., Moore, M.A., Pedersen, R.A., and Daley, G.Q. (2007). Recombination Signatures Distinguish Embryonic Stem Cells Derived by Parthenogenesis and Somatic Cell Nuclear Transfer. Cell Stem Cell 1, 346-352.

Levillayer, F., Mas, M., Levi-Acobas, F., Brahic, M., and Bureau, J.F. (2007). Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases. Genetics 176, 1835-1844.

Maller, J.B., Fagerness, J.A., Reynolds, R.C., Neale, B.M., Daly, M.J., and Seddon, J.M. (2007). Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nat Genet 39, 1200-1201.

Manolio, T.A., Rodriguez, L.L., Brooks, L., Abecasis, G., Ballinger, D., Daly, M., Donnelly, P., Faraone, S.V., Frazer, K., Gabriel, S., Gejman, P., Guttmacher, A., Harris, E.L., Insel, T., Kelsoe, J.R., Lander, E., McCowin, N., Mailman, M.D., Nabel, E., Ostell, J., Pugh, E., Sherry, S., Sullivan, P.F., Thompson, J.F., Warram, J., Wholley, D., Milos, P.M., and Collins, F.S. (2007). New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet 39, 1045-1051.

Poirier, C., Moran, J.L., Kovanci, E., Petit, D.C., Beier, D.R., and Bishop, C.E. (2007). Three loci on mouse chromosome 5 and 10 modulate sex determination in XX Ods/+ mice. Genesis 45, 452-455.

Price, A.L., Patterson, N., Yu, F., Cox, D.R., Waliszewska, A., McDonald, G.J., Tandon, A., Schirmer, C., Neubauer, J., Bedoya, G., Duque, C., Villegas, A., Bortolini, M.C., Salzano, F.M., Gallo, C., Mazzotti, G., Tello-Ruiz, M., Riba, L., Aguilar-Salinas, C.A., Canizales-Quinteros, S., Menjivar, M., Klitz, W., Henderson, B., Haiman, C.A., Winkler, C., Tusie-Luna, T., Ruiz-Linares, A., and Reich, D. (2007). A genomewide admixture map for Latino populations. Am J Hum Genet 80, 1024-1036.

Seddon, J.M., Francis, P.J., George, S., Schultz, D.W., Rosner, B., and Klein, M.L. (2007). Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration. JAMA 297, 1793-1800.

Shaffer, J.R., Kammerer, C.M., Reich, D., McDonald, G., Patterson, N., Goodpaster, B., Bauer, D.C., Li, J., Newman, A.B., Cauley, J.A., Harris, T.B., Tylavsky, F., Ferrell, R.E., and Zmuda, J.M. (2007). Genetic markers for ancestry are correlated with body composition traits in older African Americans. Osteoporos Int 18, 733-741.

Taconic | Newsroom | 2007 | 129s6/SvEvTac Genetic Integrity Comes Clean.

2006

Li, M., Atmaca-Sonmez, P., Othman, M., Branham, K. E., Khanna, R., Wade, M. S., Li, Y., Liang, L., Zareparsi, S., Swaroop, A., and Abecasis, G. R. (2006). CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet 38, 1049-1054.

Maller, J., George, S., Purcell, S., Fagerness, J., Altshuler, D., Daly, M. J., and Seddon, J. M. (2006). Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet 38, 1055-1059.

Seddon, J. M., George, S., Rosner, B., and Klein, M. L. (2006). CFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degeneration. Hum Hered 61, 157-165.

 

Contact

The NIH/NCRR program has ended. Collaborators interested in performing genotyping or expression studies at the Broad Institute should contact the Genetic Analysis Platform at gap_info@broadinstitute.org.