Jon Clardy is a co-director of the Infectious Disease Program at the Broad Institute and a professor in the Department of Biological Chemistry and Molecular Pharmacology at the Harvard Medical School. His research involves many aspects of biologically active small molecules, especially those known as natural products. In the area of malaria, Clardy’s laboratory defined the structure of a crucial enzymatic target, P. falciparum's dihydroorotate dehydrogenase (DHODH), for antimalarial agents, and the lab is currently exploring the liver stage of the malaria parasite through phenotypic screening. Most members of his laboratory work on bacterial systems with an emphasis on understanding how endogenously produced small molecules control lifestyles, pathogenesis, and eukaryotic development.
Clardy graduated Phi Beta Kappa from Yale University and received his Ph.D. from Harvard University, both in chemistry. He joined the chemistry faculty of Iowa State University and a few years later moved to Cornell University where he remained for over 20 years. He has received many awards for his research including fellowships from the Alfred P. Sloan Foundation, the Camille and Henry Dreyfus Foundation, and the John Simon Guggenheim Memorial Foundation. He has also received the Ernest Guenther Award and an Arthur C. Cope Scholar Award from the American Chemical Society, and the Research Achievement Award from the American Society of Pharmacognosy. He is a Fellow of the American Academy of Arts and Sciences and the American Association for the Advancement of Science, and won Cornell's highest award for teaching in the College of Arts and Sciences.