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Publications

The following publications have benefited, directly or indirectly, from the National Cancer Institute’s Initiative for Chemical Genetics. Direct benefits include screening, assay development, synthetic chemistry, analytical chemistry and computational support at the ICG. Indirect benefits include the mining of assay or chemical data that were originally developed at the ICG.

Publications based on research performed with the support of the ICG should include the following acknowledgement:

The project has been funded in whole or in part with Federal funds from the National Cancer Institute's Initiative for Chemical Genetics, National Institutes of Health, under Contract No. N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Service, nor does mention of trade names, commercial products or organizations imply endorsement by the U.S. Government.

Reviews and Interviews

2003 | 2004 | 2005 | 2006 | 2007 | 2008

2008

Seiler KP, George GA, Happ MP, Bodycombe NE, Carrinski HA, Norton S, Brudz S, Sullivan JP, Muhlich J, Serrano M, Ferraiolo P, Tolliday NJ, Schreiber SL, Clemons PA. (2008). ChemBank: a small-molecule screening and cheminformatics resource database. Nucleic Acids Res. 36(Database issue):D351-9. [PubMed]

2007

Ramanathan A, Schreiber SL. (2007). Multilevel regulation of growth rate in yeast revealed using systems biology. J. Biol. 6(2):3. [PubMed]

2006

Tolliday, N., Clemons, P.A., Ferraiolo, P., Koehler, A.N., Lewis, T.A., Li, X., Schreiber, S.L., Gerhard, D.S., Eliasof, S. (2006). Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics. Caner. Res. 66(18), 8935-42. [PubMed]

2005

Butcher, R.A., Schreiber, S.L. (2005). Using genome-wide transcriptional profiling to elucidate small-molecule mechanism. Curr. Op. Chem. Biol. 9, 25-30. [PubMed]

Mitchison, T.J. (2005). Small-molecule screening and profiling by using automated microscopy. Chembiochem. 6(1), 33-39. [PubMed]

Schreiber S.L (2005). Small molecules: the missing link in the central dogma. Nature Chem. Biol. 1(2), 64-66 [PubMed]

2004

Burke, M.D., Schreiber, S.L. (2004). A planning strategy for diversity-oriented synthesis. Angew Chem. Int. Ed. En. 43(1), 46-58. [PubMed]

Clemons, P.A. (2004). Complex phenotypic assays in high-throughput screening. Curr. Opin. Chem. Biol. 8(3), 334-8. [PubMed]

Haggarty, S.J., Clemons, P.A., Wong, J.C., Schreiber, S.L. (2004). Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors. Comb. Chem. High Throughput Screen. 7(7), 669-76. [PubMed]

Kau, T.R., Way, J.C., Silver, P.A. (2004). Nuclear transport and cancer: from mechanism to intervention. Nature Reviews Cancer 4(2), 1-12. [PubMed]

Kim, T.K. (2004). Chemical genomics and medicinal systems biology: chemical control of genomic networks in human systems biology for innovative medicine. J. Biochem. Mol. Biol. 37(1), 53-8. [PubMed]

Peterson, R.T., Fishman, M.C. (2004). Discovery and use of small molecules for probing biological processes in zebrafish. Methods Cell. Biol.76, 569-91. [PubMed]

Wagner, B.K., Haggarty, S.J., Clemons, P.A. (2004). Chemical genomics: probing protein function using small molecules. Am. J. Pharmacogenomics 4(5), 313-20. [PubMed]

2003

Flaumenhaft, R., Sim, D.S. (2003). The platelet as a model for chemical genetics. Chem. Biol. 10(6), 481-6. [PubMed]

Kau, T.R., Silver, P.A. (2003). Nuclear transport as a target for cell growth. Drug Discov. Today 8(2), 78-85. [PubMed]

Schreiber, S.L. (2003). The small-molecule approach to biology: Chemical genetics and diversity-oriented organic synthesis make possible the systematic exploration of biology. Chem. & Eng. News 81, 51-61. [Article]

Strausberg, R.L., Schreiber, S.L. (2003). From knowing to controlling: a path from genomics to drugs using small molecule probes. Science 300(5617), 294-5. [PubMed]

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Research articles

1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008

2008

Christofk HR, Vander Heiden MG, Ramanathan A, Gerszten RE, Schreiber SL, Cantley LC.(2008). The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 452(7184):230-3. [PubMed]

Dhakal BK, Mulvey MA. (2008). Uropathogenic Escherichia coli invade host cells via an HDAC6-modulated microtubule-dependent pathway. J Biol Chem. 2008 Nov 6. [Epub ahead of print] [PubMed]

Dobrovolskaia MA, Aggarwal P, Hall JB, McNeil SE. (2008). Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. Mol Pharm. 5(4):487-95. [PubMed]

Ivey F.D., Wang L., Demirbas D., Allain C., and Hoffman C.S. (2008). Development of a fission yeast-based high throughput screen to identify chemical regulators of cAMP phosphodiesterases. Journal of Biomolecular Screening 13(1):62-71. [PubMed]

Jiang Q, Ren Y, Feng J. (2008). Direct Binding with Histone Deacetylase 6 Mediates the Reversible Recruitment of Parkin to the Centrosome. J. Neurosci. 28(48):12993-13002. [PubMed]

Nelson EA, Walker SR, Kepich A, Gashin LB, Hideshima T, Ikeda H, Chauhan D, Anderson KC, Frank DA. (2008) Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3 Blood. 29 September 2008. [Epub ahead of print] [PubMed]

Nieland TJF, Shaw JT, Jaipuri FA, Duffner JL, Koehler AN, Banakos S, Bannis VI, Kirchhausen T, Krieger M. (2008). Identification of the Molecular Target of Small Molecule Inhibitors of HDL Receptor SR-BI Activity. Biochemistry. 47(1):460-72. [PubMed]

Nielsen TE and Schreiber SL. (2008). Towards the optimal screening collection: a synthesis strategy. Angewandte Chemie 47(1):48-56. [PubMed]

O'Brien K, Matlin AJ, Lowell AM, Moore MJ. (2008). The biflavonoid isoginkgetin is a general inhibitor of pre-mRNA splicing. J Biol Chem. 283(48):33147-54. [PubMed]

Rao R, Fiskus W, Yang Y, Lee P, Joshi R, Fernandez P, Mandawat A, Atadja P, Bradner JE, Bhalla K. (2008). HDAC6 inhibition enhances 17-AAGmediated abrogation of hsp90 chaperone function in human leukemia cells Blood. 112(5):1886-1893. [PubMed]

Schuetz A, Min J, Allali-Hassani A, Schapira M, Shuen M, Loppnau P, Mazitschek R, Kwiatkowski NP, Lewis TA, Maglathin RL, McLean TH, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH. (2008). Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity. J. Biol. Chem. 283(17):11355-11363. [PubMed]

Shan B, Yao T, Nguyen HT, Zhuo Y, Levy DR, Klingsberg RC, Tao H, Palmer ML, Holder KN, Lasky JA. (2008). Requirement of HDAC6 for Transforming Growth Factor-?1-induced Epithelial-Mesenchymal Transition. J. Biol. Chem. 283(30):21065-21073. [PubMed]

Shaw SY, Westly EC, Pittet MJ, Subramanian A, Schreiber SL, Weissleder R. (2008). Perturbational profiling of nanomaterial biologic activity PNAS. 105(21):7387-7392. [PubMed]

Vegas AJ, Fuller JH, Koehler AN. (2008). Small-Molecule Microarrays as Tools in Ligand Discovery. Chem. Soc. Rev. 37(7):1385-94. [PubMed]

Wagner BK, Carrinski H, Anh Y-H, Gilbert TJ, Fomina D, Schreiber SL, Chang Y-T, Clemons PA. (2008). Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening. 130(13):4208-9. [PubMed]

Wagner BK, Kitami T, Gilbert TA, Peck D, Ramanathan A, Schreiber SL, Golub T,Mootha V. (2008). Large-scale chemical dissection of mitochondrial function. Nature Biotech. 26(3):343-51. [PubMed]

Wang X, Imber BS, Schreiber SL. (2008). Small-molecule reagents for cellular pull-down experiments. Bioconjugate Chem., 19(3):585-7. [PubMed]

Witte H, Neukirchen D, Bradke F. (2008). Microtubule stabilization specifies initial neuronal polarization. J. Cell Biol. 180(3):619-32. [PubMed]

2007

Kim SS, Peng LF, Lin W, Choe WH, Sakamoto N, Kato N, Ikeda M, Schreiber SL, Chung RT. (2007). A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication. Gastroenterology. 132(1):311-20 [PubMed]

Lynch, R.A., Etchin, J., Battle, T.E., Frank, D.A. (2007). A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of ifn-γ in human cancer cells. Cancer Res. 67(3), 1254-1261. [PubMed]

Miao H, Tallarico JA, Hayakawa H, Munger K, Duffner JL, Koehler AN, Schreiber SL, Lewis TA. (2007). Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules. J. Comb. Chem. 9(2):245-53. [PubMed]

Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA Jr, Schreiber SL, Chung RT. (2007). Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrob Agents Chemother. 51(10):3756-9. [PubMed]

Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. (2007). Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat. Chem. Biol. 3(6):331-8. [PubMed]

Vegas AJ, Bradner JE, Tang W, McPherson OM, Greenberg EF, Koehler AN, Schreiber SL. (2007). Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors. Angew. Chem. Int. Ed. Engl. 46(42):7960-4. [PubMed]

Yang J, Shamji A, Matchacheep S, Schreiber SL. (2007). Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening. Chem. Biol. 14(4):371-7. [PubMed]

2006

Baniecki, M.L., Wirth, D.F., Clardy, J. (2006). A high-throughput plasmodium falciparum growth assay for malaria drug discovery. Antimicrob Agents Chemother (Epub ahead of print) [PubMed]

Baur, J.A., Pearson, K.J., Price, N.L., Jamieson, H.A., Lerin, C., Kalra, A., Prabhu, V.V., Allard, J.S., Lopez-Lluch, G., Lewis, K., Pistell, P.J., Poosala, S., Becker, K.G., Boss, O., Gwinn, D., Wang, M., Ramaswamy, S., Fishbein, K.W., Spencer, R.G., Lakatta, E.G., Le Couteur, D., Shaw, R.J., Navas, P., Puigserver, P., Ingram, D.K., de Cabo, R., Sinclair, D.A. (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444(7117), 337-42. [PubMed]

Bradner, J.E., McPherson, O.M., Koehler, A.N. (2006). A method for the covalent capture and screening of diverse small molecules in a microarray format. Nature Protocols 1, 2344-2352. [Nature online]

Bradner, J.E., McPherson, O.M., Mazitschek, R., Barnes-Seeman, D., Shen, J.P., Dhaliwal, J., Stevenson, K.E., Duffner, J.L., Park, S.B., Neuberg, D.S., Nghiem, P., Schreiber, S.L., Koehler, A.N. (2006). A robust small-molecule microarray platform for screening cell lysates. Chem. Biol. 13(5), 493-504. [PubMed]

Butcher, R.A., Bhullar, B.S., Perlstein, E.O., Marsischky, G., LaBaer, J., Schreiber, S.L. (2006). Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway. Nat Chem. Biol. 2(2), 103-9. [PubMed]

Butcher, R.A., Schreiber, S.L. (2006). A microarray-based protocol for monitoring the growth of yeast overexpression strains. Nature Protocols 1, 569-576. [Abstract]

Cabrero, J.R., Serrador, J.M., Barreiro, O., Mittelbrunn, M., Naranjo-Suarez, S., Martin-Cofreces, N., Vicente-Manzanares, M., Mazitschek, R., Bradner, J.E., Avila, J., Valenzuela-Fernandez, A., Sanchez-Madrid, F. (2006). Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. Mol. Biol. Cell 17(8), 3435-45. [PubMed]

Carta, S., Tassi, S., Semino, C., Fossati, G., Mascagni, P., Dinarello, C.A., Rubartelli, A. (2006). Histone deacetylase inhibitors prevent exocytosis of interleukin-1?A`-containing secretory lysosomes: role of microtubules. Blood 108(5), 1618-26. [PubMed]

Chirnomas, D., Taniguchi, T., de la Vega, M., Vaidya, A.P., Vasserman, M., Hartman, A.R., Kennedy, R., Foster, R., Mahoney, J., Seiden, M.V., D'Andrea, A.D. (2006). Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway. Mol. Cancer Ther. 5(4), 952-61. [PubMed]

De Wall, S.L., Painter, C., Stone, J.D., Bandaranayake, R., Wiley, D.C., Mitchison, T.J., Stern, L.J., and DeDecker, B.S. (2006). Noble metals strip peptides from class II MHC proteins. Nature Chem. Biol. (4), 178-9. [PubMed]

Duan, Z., Bradner, J.E., Greenberg, E., Levine, R., Foster, R., Mahoney, J., Seiden, M.V. (2006). SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation. Clin Cancer Res 12(22), 6844-52. [PubMed]

Frey, G., Rits-Volloch, S., Zhang, X.Q., Schooley, R.T., Chen, B., Harrison, S.C. (2006). Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion. Proc. Natl. Acad. Sci. USA 103(38), 13938-43. [PubMed]

Hieronymus, H., Lamb, J., Ross, K.N., Peng, X.P., Clement, C., Rodina, A., Nieto, M., Du, J., Stegmaier, K., Raj, S.M., Maloney, K.N., Clardy, J., Hahn, W.C., Chiosis, G., Golub, T.R. (2006). Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell 10(4), 321-30. [PubMed]

Klekota, J., Brauner, E., Roth, F.P., Schreiber, S.L. (2006). Using high-throughput screening data to discriminate compounds with single-target effects from those with side effects. J. Chem. Inf. Model. 46(4), 1549-62. [PubMed]

Klekota, J., Roth, F.P., Schreiber, S.L. (2006). Query Chem: a Google-powered web search combining text and chemical structures. Bioinformatics 22(13), 1670-3. [PubMed]

Kumagai, N., Muncipinto, G., Schreiber, S.L. (2006). Short synthesis of skeletally and stereochemically diverse small molecules by coupling Petasis condensation reactions to cyclization reactions. Angewandte Chemie 45, 3635-3638. [PubMed]

Lamb, J., Crawford, E.D., Peck, D., Modell, J.W., Blat, I.C., Wrobel, M.J., Lerner, J., Brunet, J.P., Subramanian, A., Ross, K.N., Reich, M., Hieronymus, H., Wei, G., Armstrong, S.A., Haggarty, S.J., Clemons, P.A., Wei, R., Carr, S.A., Lander, E.S., Golub, T.R. (2006). The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313(5795), 1929-35. [PubMed]

Lee, V.T., Pukatzki, S., Sato, H., Kikawada, E., Kazimirova, A.A., Huang, J., Li, X., Arm, J.P., Frank, D.W., Lory, S. (2006). PseudolipasinA is a specific inhibitor for phospholipase A2 activity of pseudomonas aeruginosa cytotoxin ExoU. Infect Immun (Epub ahead of print) [PubMed]

Looper, R.E., Pizzirani, D., Schreiber, S.L. (2006). Macrocycloadditions leading to conformationally restricted small molecules. Org. Lett. 8, 2063-2066. [PubMed]

Loregian, A., Coen, D.M. (2006). Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase. Chem. Biol. 13(2), 191-200. [PubMed]

Macia, E., Ehrlich, M., Massol, R., Boucrot, E., Brunner, C., Kirchhausen, T. (2006). Dynasore, a cell-permeable inhibitor of dynamin. Dev. Cell. 10(6), 839-50. [PubMed]

Maliga, Z., Mitchison, T.J. (2006). Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC Chem. Biol. 6, 2. [PubMed]

Malo, N., Hanley, J.A., Cerquozzi, S., Pelletier, J., Nadon, R. (2006). Statistical practice in high-throughput screening data analysis. Nat Biotechnol 24(2), 167-75. [PubMed]

Martyn, D.C., Jones, D.C., Fairlamb, A.H., Clardy, J. (2006). High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett (Epub ahead of print) [PubMed]

Mitchell ,J.M., Shaw, J.T. (2006). A structurally diverse library of polycyclic lactams resulting from systematic placement of proximal functional groups. Angew. Chem. Int. Ed. 45, 1722 1726. [PubMed]

Mosley, A.J., Meekings, K.N., McCarthy, C., Shepherd, D., Cerundolo, V., Mazitschek, R., Tanaka, Y., Taylor, G.P., Bangham, C.R. (2006). Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell anti-viral function in HTLV-I infection. Blood 108(12), 3801-7. [PubMed]

Pelish, H.E, Peterson, J.R., Salvareeza, S.B., Rodriquez-Boulan, E., Nazef, N., Annis, D. A., Chen, J.-L., Stamnes, M., Feng, Y., Shair, M.D., Kirchhausen, T. (2006). Secramine inhibits cdc42-dependent functions in cells and cdc42 activation in vitro. Nature Chemical Biology 2, 39-46. [PubMed]

Perlstein, E.O., Ruderfer, D.M., Ramachandran, G., Haggarty, S.J., Kruglyak, L., Schreiber, S.L. (2006). Revealing complex traits with small molecules and naturally recombinant yeast strains. Chem. Biol. 13(3), 236-8. [PubMed]

Peterson, J.R., Lebensohn, A.M., Pelish, H.E., Kirschner, M.W. (2006) Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem. Biol. 13(4), 443-52. [PubMed]

Santander, V.S., Bisig, C.G., Purro, S.A., Casale, C.H., Arce, C.A., Barra, H.S. (2006). Tubulin must be acetylated in order to form a complex with membrane Na(+),K (+) ATPase and to inhibit its enzyme activity. Mol. Cell. Biochem. 291(1-2), 167-74. [PubMed]

Smith, P.L., Maloney, K.N., Pothen, R.G., Clardy, J., Clapham, D.E. (2006). Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J. Biol. Chem. 281(40), 29897-904. [PubMed]

Spiegel, D.A., Schroeder, F.C., Duvall, J.R., Schreiber, S.L. (2006). An oligomer-based approach to skeletal diversity in small-molecule synthesis. J. Am. Chem. Soc. In press. [PubMed]

Taylor, A.M., Schreiber, S.L. (2006). Enantioselective addition of terminal alkynes to isolated isoquinoline iminiums. Org. Lett., 8, 143-146. [PubMed]

Wetli, H.A., Buckett, P.D., Wessling-Resnick, M. (2006). Small-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake. Chem. Biol. 13(9), 965-72. [PubMed]

Yang, H., Baur, J.A., Chen, A., Miller, C., Sinclair, D.A. (2006). Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell (Epub ahead of print) [PubMed]

Zaarur, N., Gabai, V.L., Porco, J.A. Jr,, Calderwood, S,, Sherman, M.Y. (2006). Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res. 66(3), 1783-91. [PubMed]

2005

Bali, P., Pranpat, M., Bradner, J., Balasis, M., Fiskus, W., Guo, F., Rocha, K., Kumaraswamy, S., Boyapalle, S., Atadja, P., Seto, E., Bhalla, K. (2005). Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J. Biol. Chem. 280(29), 26729-34. [PubMed]

Boyce, M., Bryant, K.F., Jousse, C., Long, K., Harding, H.P., Scheuner, D., Kaufman, R.J., Ma, D., Coen, D.M., Ron, D., Yuan, J. (2005). A selective inhibitor of eIF2?? dephosphorylation protects cells from ER stress. Science (307), 935-939. [PubMed]

Brady, S.F., Clardy, J. (2005). Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA. Angew Chem. Int Ed. Engl. 44(43), 7063-5. [PubMed]

Brady, S.F., Clardy, J. (2005). N-acyl derivatives of arginine and tryptophan isolated from environmental DNA expressed in Escherichia coli. Org. Lett. 7(17), 3613-6. [PubMed]

Brittian, D.E.A., Gray, B.L., Schreiber, S.L. (2005). From solution phase to solid phase enyne metathesis: Crossover in the relative performances of two commonly used ruthenium pre-catalysts. Chem. Eur. J. 11, 5086-5093. [PubMed]

Chen, C., Li, X., Neumann, C.S., Lo, M.-C.L., Schreiber, S.L. (2005). Convergent diversity-oriented synthesis of small-molecule hybrids. Angew. Chemie. Int. Ed. 44, 2249-2252. [PubMed]

Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G.D., Mitchison, T.J., Moskowitz, M., Yuan, J. (2005). Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chem. Biol. 1(2), 112-119. [PubMed]

Dorer, R.K., Zhong, S., Tallarico, J.A., Wong, W.H., Mitchison, T.J., Murray, A.W. (2005). A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes. Curr. Biol. 15(11), 1070-1076. [PubMed]

Forman, J.J., Clemons, P.A., Schreiber, S.L., Haggarty, S.J. (2005). SpectralNET--an application for spectral graph analysis and visualization. BMC Bioinformatics. 6,260. [PubMed]

Girke, T., Cheng, L.C., Raikhel, N. (2005). ChemMine. A compound mining database for chemical genomics. Plant Physiol. 138(2), 573-7. [PubMed]

Goldberg, I.G., Allan, C., Burel, J.M., Creager, D., Falconi, A., Hochheiser, H., Johnston, J., Mellen, J., Sorger, P.K., Swedlow, J.R. (2005). The Open Microscopy Environment (OME) data model and XML file: open tools for informatics and quantitative analysis in biological imaging. Genome Biol. 6(5), R47. [PubMed]

Georgiades, S.N., Clardy J. (2005) Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export. Org. Lett. 7(19), 4091-4094. [PubMed]

Griffiths, A., Coen, D.M. (2005). An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene. Proc. Natl. Acad. Sci. USA 102(27), 9667-72. [PubMed]

Gross, B.J., Kraybill, B.C., Walker, S. (2005). Discovery of O-GlcNAc transferase inhibitors. J. Am. Chem. Soc. 127(42), 14588-9. [PubMed]

Hideshima, T., Bradner, J.E., Wong, J., Chauhan, D., Richardson, P., Schreiber, S.L., Anderson, K.C. (2005). Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc. Natl. Acad. Sci. U.S.A. 102(24), 8567-72. [PubMed]

Hung, D.T., Shakhnovich, E.A., Pierson, E., Mekalanos, J.J. (2005). Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science 310(5748), 670-4. [PubMed]

Iwata, A., Riley, B.E., Johnston, J.A., Kopito, R.R. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J. Biol. Chem. 280(48), 40282-92. [PubMed]

Kang, S., Li, H., Rao, A., Hogan, P.G. (2005). Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site. J. Biol. Chem. 280(45), 37698-706. [PubMed]

Kevorkov, D., Makarenkov, V. (2005). Statistical analysis of systematic errors in high-throughput screening. J. Biomol. Screen. 10(6), 557-67. [PubMed]

Kumar, N., Kiuchi, M., Tallarico, J.A., Schreiber, S.L. (2005). Small-molecule diversity using a skeletal transformation strategy. Org. Lett. 7(13), 2535-8. [PubMed]

Loregian, A., Coen, D.M. Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase. Chem Biol 13(2), 191-200. [PubMed]

Marcus, A.I., Zhou, J., O'Brate, A., Hamel, E., Wong, J., Nivens, M., El-Naggar, A., Yao, T.P., Khuri, F.R., Giannakakou, P. (2005). The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. Cancer Res. 65(9):3883-93. [PubMed]

Nieland, T.J., Ehrlich, M., Krieger, M., Kirchhausen, T. (2005). Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI. Biochim Biophys Acta. 1734(1), 44-51. [PubMed]

Oguri, H., Schreiber, S.L. (2005). Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons. Org. Lett. 7(1), 47-50. [PubMed]

Perlman, Z.E., Mitchison, T.J., Mayer, T.U. (2005). High-content screening and profiling of drug activity in an automated centrosome-duplication assay. Chembiochem 6(1), 145-151. [PubMed]

Ramanathan, A., Wang, C., Schreiber, S.L. (2005). Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc. Natl. Acad. Sci. U.S.A. 102(17), 5992-7. [PubMed]

Saji, S., Kawakami, M., Hayashi, S., Yoshida, N., Hirose, M., Horiguchi, S., Itoh, A., Funata, N, Schreiber, S.L., Yoshida, M., Toi, M. (2005). Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene 24(28), 4531-9. [PubMed]

Schroeder, F.C, Kau T.R., Silver, P.A., Clardy, J. (2005) The psammaplysenes, specific inhibitors of FOXO1a nuclear export. J. Nat. Prod. 68, 574-576. [PubMed]

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Surpin, M., Rojas-Pierce, M., Carter, C., Hicks, G.R., Vasquez, J., Raikhel, N.V. (2005). The power of chemical genomics to study the link between endomembrane system components and the gravitropic response. Proc. Nat. Acad. Sci. U.S.A. 102(13), 4902-7. [PubMed]

Toenjes, K.A., Munsee, S.M., Ibrahim, A.S., Jeffrey, R., Edwards, J.E. Jr,, Johnson, D.I. (2005). Small-molecule inhibitors of the budded-to-hyphal-form transition in the pathogenic yeast Candida albicans. Antimicrob Agents Chemother 49(3), 963-72. [PubMed]

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Yarrow, J.C., Totsukawa, G., Charras, G.T., Mitchison, T.J (2005). Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol. 12(3), 385-95. [PubMed]

Zaarur, N., Vladimir L. Gabai, V.L., Porco, J.A. Jr., Calderwood, S., Sherman, M.Y. Targeting heat shock response to sensitize cancer cells to proteasome and hsp90 inhibitors. Cancer Res. 66(3), 1783-91. [PubMed]

2004

Armstrong, J. I., Yuan, S., Dale, J. M., Tanner, V. N. and Theologis, A. (2004). Identification of inhibitors of auxin transcriptional activation by means of chemical genetics in Arabidopsis. Proc. Natl. Aacad. Sci. USA 101, 14978-14983. [PubMed]

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Boutros, M., Kiger, A.A., Armknecht, S., Kerr, K., Hild, M., Koch, B., Haas, S.A., Paro, R., Perrimon, N. Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 303(5659), 832-5. [PubMed]

Butcher, R. Schreiber, S.L. (2004). Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection. Proc. Nat. Acad. Sci. U.S.A. 101(21), 7868-7873. [PubMed]

Carey, K.L., Westwood, N.J., Mitchison, T.J., Ward, G.E. (2004). A small-molecule approach to studying invasive mechanisms of toxoplasma gondii. Proc. Nat. Acad. Sci. U.S.A. 101, 7433-7438. [PubMed]

Cerny, J., Feng, Y., Yu, A., Miyake, K., Borgonovo, B., Klumperman, J., Meldolesi, J., McNeil, P.L., Kirchhausen, T. (2004). The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep. 5(9), 883-8. [PubMed]

Cheng, D., Yadav, N., King, R.W., Swanson, M.S., Weinstein, E.J., Bedford, M.T. (2004). Small molecule regulators of protein arginine methyltransferases. J. Biol. Chem. 279(23), 23892-9. [PubMed]

Cohen, H.Y., Lavu, S., Bitterman, K.J., Hekking, B., Imahiyerobo, T.A., Miller, C., Frye, R., Ploegh, H., Kessler, B.M., Sinclair, D.A. (2004). Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell 13(5), 627-38. [PubMed]

Corcoran, L.J., Mitchison, T.J., Liu, Q. (2004). A novel action of histone deacetylase inhibitors in a protein aggresome disease model. Curr. Biol. 14(6), 488-92. [PubMed]

Eggert, U.S., Kiger, A.A., Richter, C., Perlman, Z.E., Perrimon, N., Mitchison, T.J., Field, C.M. (2004). Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2(12), 2135-43. [PubMed]

Fantin V.R., Leder, P. (2004). F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 64(1), 329-36. [PubMed]

Feng, Y., Jadhav, A.P., Rodighiero, C., Fujinaga, Y., Kirchhausen, T., Lencer, W.I. (2004). Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep. 5(6), 596-601. [PubMed]

Fiebiger, E., Hirsch, C., Vyas, J.M., Gordon, E., Ploegh, H.L., Tortorella, D. (2004). Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Mol. Biol. Cell 15(4), 1635-46. [PubMed]

Haggarty, S.J., Clemons, P.A., Wong, J.C., Schreiber, S.L. (2004). Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors. Comb. Chem. High Throughput Screen. 7(7), 669-76. [PubMed]

Hu, Y., Helm, J.S., Chen, L., Ginsberg, C., Gross, B., Kraybill, B., Tiyanont, K., Fang, X., Wu, T., Walker, S. (2004). Identification of selective inhibitors for the glycosyltransferase MurG via high-throughput screening. Chem. Biol. 11(5), 703-11. [PubMed]

Huang J, Zhu H, Haggarty SJ, Spring DR, Hwang H, Jin F, Snyder M, Schreiber SL (2004). Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc. Natl. Acad. Sci.U.S.A. 101(47), 16594-9. [PubMed]

Kim, Y.K., Arai, M.A., Arai, T., Lamenzo, J.O., Dean, E.F. 3rd, Patterson, N., Clemons, P.A., Schreiber, S.L. (2004). Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space. J. Am. Chem. Soc. 126(45), 14740-5. [PubMed]

Li, H., Rao, A., Hogan, P.G. (2004). Structural delineation of the calcineurin-NFAT interaction and its parallels to PP1 targeting interactions. J. Mol. Biol. 342, 1659-1674. [PubMed]

Limouze, J., Straight, A.F., Mitchison, T., Sellers, J.R. (2004). Specificity of blebbistatin, an inhibitor of myosin II. J. Muscle Res. Cell. Motil. 25(4-5), 337-41. [PubMed]

Lo, M.M., Neumann, C.S., Nagayama, S., Perlstein, E.O., Schreiber, S.L. (2004). A library of spirooxindoles based on a stereoselective three-component coupling reaction. J. Am. Chem. Soc. 126(49):16077-86. [PubMed]

Margalit, D.M., Romberg, L., Mets, R.B., Hebert, A.M., Mitchison, T.J., Kirschner, M.W., RayChaudhuri, D. (2004). Targeting cell division: Small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc. Natl. Acad. Sci. U.S.A. 101(32), 11821-6. [PubMed]

Misaghi, S., Pacold, M.E., Blom, D., Ploegh, H.L., Korbel, G.A. (2004). Using a small molecule inhibitor of Peptide: N-glycanase to probe its role in glycoprotein turnover. Chem. Biol. (12), 1677-87. [PubMed]

Nieland, T.J., Chroni, A., Fitzgerald, M.L., Maliga, Z., Zannis, V.I., Kirchhausen, T., Krieger, M. (2004). Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide. J. Lipid Res. 45, 1256-1265. [PubMed]

Nieland, T.J., Feng, Y., Brown, J.X., Chuang, T.D., Buckett, P.D., Wang, J., Xie, X.S., McGraw, T.E., Kirchhausen, T., Wessling-Resnick, M. (2004). Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic. Traffic 5(7), 478-92. [PubMed]

Ohi, R., Sapra, T., Howard, J., Mitchison, T.J. (2004). Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol. Biol. Cell 15(6), 2895-906. [PubMed]

Perlman, Z.E., Slack, M.D., Feng, Y., Mitchison T.J., Wu, L.F. Altschuler, S.J. (2004). Multidimensional drug profiling by automated microscopy. Science 306: 1194-1198. [PubMed]

Peterson, J.R., Bickford, L.C., Morgan, D., Kim, A.S., Ouerfelli, O., Kirschner, M.W., Rosen, M.K. (2004). Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat. Struct. Mol. Biol. 11(8), 747-55. [PubMed]

Peterson, R.T., Shaw, S.Y., Peterson, T.A., Milan, D.J., Zhong, T.P., Schreiber, S.L. MacRae, C.A., Fishman, M.C. (2004). Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat. Biotechnol. 22(5), 595-9. [PubMed]

Pilger, B.D., Cui, C., Coen, D.M. (2004). Identification of a small molecule that inhibits herpes simplex virus DNA polymerase subunit interactions and viral replication. Chem. Biol. 11(5), 647-54. [PubMed]

Ramachandran, N., Hainsworth, E., Bhullar, B., Eisenstein, S., Rosen, B., Lau, A.Y., Walter, J.C., LaBaer, J. (2004). Self-assembling protein microarrays. Science 305(5680), 86-90. [PubMed]

Roehrl, M.H.A., Kang, S., Aramburu, J., Wagner, G., Rao, A, Hogan, P.G. (2004). Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc. Natl. Acad. Sci. U.S.A. 101(20), 7554-9. [PubMed]

Roehrl, M.H.A., Wang., Wagner, G. (2004). A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization. Biochemistry 43, 16056-16066. [PubMed]

Roehrl, M.H.A., Wang., Wagner, G. (2004). Discovery of small-molecule inhibitors of the NFAT-calcineurin interaction by competitive high-throughput fluorescence polarization screening, Biochemistry 43, 16067-16075. [PubMed]

Sim, D.S., Merrill-Skoloff, G., Furie, B.C., Furie, B., Flaumenhaft, R. (2004). Initial accumulation of platelets during arterial thrombus formation in vivo is inhibited by elevation of basal cAMP levels. Blood 103(6), 2127-34. [PubMed]

Venkatesh, N., Feng, Y., DeDecker, B., Yacono, P., Golan, D., Mitchison, T., McKeon, F. (2004). Chemical genetics to identify NFAT inhibitors: Potential of targeting calcium mobilization in immunosuppression. Proc. Natl. Acad. Sci. U.S.A. 101(24), 8969-74. [PubMed]

Verma, R., Peters, N.R., D?fOnofrio, M., Tochtrop, G.P., Sakamoto, K.M., Varadan, R., Zhang, M., Coffino, P., Fushman, D., Deshaies, R.J., King, R.W. (2004). Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science 306(5693), 117-20. [PubMed]

Wong, J.C., Sternson, S.M., Louca, J.B., Hong, R., Schreiber, S.L. (2004). Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes. Chem. Biol. 11(9), 1279-91. [PubMed]

Wood, J.G., Rogina, B., Lavu, S., Howitz, K., Helfand, S.L., Tatar, M., Sinclair, D. (2004). Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430(7000), 686-9. [PubMed]

Yarrow, J.C., Perlman, Z.E., Westwood, N.J., Mitchison, T.J. (2004). A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods. BMC Biotechnol. 4: 21. [PubMed]

2003

Barnes-Seeman, D., Park, S.B., Koehler, A.N., Schreiber, S.L. (2003). Expanding the functional group compatibility of small-molecule microarrays: Discovery of novel calmodulin ligands. Angewandte Chemie. 42, 2376-2379. [PubMed]

Burke, M.D., Berger, E.M., Schreiber, S.L. (2003). Generating diverse skeletons of small molecules combinatorially. Science 302(5645), 613-8. [PubMed]

Butcher, R., Schreiber, S.L. (2003). A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae. Chem. Biol. 10, 521-531. [PubMed]

Canman, J.C., Cameron, L.A., Maddox, P.S., Straight, A., Tirnauer, J.S., Mitchison, T.J., Fang, G., Kapoor, T.M., Salmon, E.D. (2003). Determining the position of the cell division plane. Nature 424, 1074-8. [PubMed]

Feng, Y., Yu, S., Lasell, T.K., Jadhav, A.P., Macia, E., Chardin, P., Melancon, P., Roth, M., Mitchison, T., Kirchhausen, T. (2003). Exo1: a new chemical inhibitor of the exocytic pathway. Proc. Natl. Acad. Sci. U.S.A. 100, 6469-74. [PubMed]

Haggarty, S.J., Clemons, P.A., Schreiber, S.L. (2003). Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations. J. Am. Chem. Soc. 125, 10543-10545. [PubMed]

Haggarty, S.J., Koeller, K.M., Kau, T.R., Silver, P.A., Roberge, M., Schreiber, S.L. (2003). Small molecule modulation of the human chromatid decatenation checkpoint. Chem. Biol. 10, 1267-79. [PubMed]

Haggarty, S.J., Koeller, K.M., Wong, J.C., Butcher, R.A., Schreiber, S.L. (2003). Multidimensional chemical genetic analysis of a combinatorial library of deacetylase inhibitors using cell-based assays. Chem. Biol. 10, 383-396. [PubMed]

Haggarty, S.J., Koeller, K.M., Wong, J.C., Grozinger, C.M., Schreiber, S.L. (2003). Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc. Natl. Acad. Sci. U.S.A. 100, 4389-4394. [PubMed]

Helm, J. S., Hu, Y., Chen, L., Gross, B., Walker, S. (2003). Identification of active-site inhibitors of MurG using a generalizable, high-throughput glycosyltransferase screen. J. Am. Chem. Soc. 125 (37), 11168-11169. [PubMed]

Howitz, K.T., Bitterman, K.J., Cohen, H.Y., Lamming, D.W., Lavu, S., Wood, J.G., Zipkin, R.E., Chung, P., Kisielewski, A., Zhang, L.L., Scherer, B., Sinclair, D.A. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425(6954), 191-6. [PubMed]

Jenkins, J.L., Kao, R.Y.T., Shapiro, R. (2003). Virtual screening to enrich hit lists from high-throughput screening: A case study on small-molecule inhibitors of angiogenin. Proteins 50(1), 81-93. [PubMed]

Jenkins, J.L., Shapiro, R. (2003). Identification of small-molecule inhibitors of human angiogenin and characterization of their binding interactions guided by computational docking. Biochemistry 42(22), 6674-87. [PubMed]

Kau, T.R., Schroeder, F., Ramazwamy, S., Wojciechowski, C.L., Zhao, J.J., Roberts, T.M., Clardy, J., Sellers, W.R., Silver, P.A. (2003). A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN deficient tumor cells. Cancer Cell 4(6), 463-476. [PubMed]

Kiger, A.A., Baum, B., Jones, S., Jones, M.R., Coulson, A, Echeverri, C., Perrimon, N. (2003). A functional genomic analysis of cell morphology using RNA interference. J. Biol. 2(4), 27. [PubMed]

Koehler, A.N., Shamji, A.F., Schreiber, S.L. (2003). Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis. J. Am. Chem. Soc. 125, 8420-8421. [PubMed]

Koeller, K.M., Haggarty, S.J., Perkins, B.D., Leykin, I., Wong, J.C., Kao, M.C.J., Schreiber, S.L. (2003). Chemical genetic modifier screens: Small molecule trichostatin suppressors as probes of acetylation in transcription, cell cycle progression, and stability of the cytoskeleton. Chem. Biol. 10, 397-410. [PubMed]

Straight, A., Cheung, A., Limouze, J., Chen, I., Westwood, N., Sellers, J., Mitchison, T. (2003). Dissecting temporal and spatial control of cytokinesis with a myosin ii inhibitor. Science 299, 1743-1747. [PubMed]

Swedlow, J.R., Goldberg, I., Brauner, E., Sorger, P.K. (2003). Informatics and quantitative analysis in biological imaging. Science 300(5616), 100-2. [PubMed]

Wang, B., Nguyen, M., Breckenridge, D.G., Stojanovic, M., Clemons, P.A., Kuppig, S., Shore, G.C. (2003). Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria. J. Biol. Chem. 278(16), 14461-8. [PubMed]

Wong, J.C., Hong, R., Schreiber, S.L. (2003). Structural biasing elements for in-cell histone deacetylase paralog selectivity. J. Am. Chem. Soc. 125, 5586-5587. [PubMed]

Yarrow, J., Feng, Y., Perlman, Z., Kirchhausen, T., Mitchison, T. (2003). Phenotypic screening of small molecule libraries by high throughput cell imaging. Comb. Chem. and High Throughput Screen. 6, 79-99. [PubMed]

Zhao, Y., Dai, X., Blackwell, H.E., Schreiber, S.L., Chory, J. (2003). SIR1, an upstream component in Auxin signaling identified by chemical genetics. Science 301, 1107-1110. [PubMed]

2002

Cheung, A., Dantzig, J.A., Hollingworth, S., Baylor, S.M., Goldman, Y.E., Mitchison, T.J., Straight, A.F. (2002). A small-molecule inhibitor of skeletal muscle myosin II. Nat. Cell Biol. 4, 83-87. [PubMed]

Fahmy, A., Wagner, G. (2002). TreeDock: a tool for protein docking based on minimizing van der Waals energies. J. Am. Chem. Soc. 124, 1241-1250. [PubMed]

Fantin, V., Berardi, M., Scorrano, L., Korsmeyer, S., Leder, P. (2002). A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell 2, 29-42. [PubMed]

Kao, R.Y.T., Jenkins, J.L., Olson, K.A., Key, M.E., Fett, J.W., Shapiro, R. (2002). A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity. Proc. Natl. Acad. Sci. U.S.A. 99, 10066-10071. [PubMed]

Kuruvilla, F.G., Shamji, A.F., Sternson, S.M., Hergenrother, P.J., Schreiber, S.L. (2002). Dissecting glucose signaling with diversity-oriented synthesis and small molecule microarrays. Nature 416, 653-656. [PubMed]

Lugovskoy, A.A., Degterev, A.I., Fahmy, A.F., Zhou, P., Gross, J.D., Yuan, J., Wagner, G. (2002). A novel approach for characterizing protein ligand complexes: Molecular basis for specificity of small-molecule Bcl-2 inhibitors. J. Am. Chem. Soc. 124, 1234-1240. [PubMed]

Maliga, Z., Kapoor, T.M., Mitchison, T.J. (2002). Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chem Biol. 9(9), 989-96. [PubMed]

Nieland, T., Penman, M., Dori, L., Krieger, M., Kirchhausen, T. (2002). Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. Proc. Natl. Acad. Sci. U.S.A. 99, 15422-15427. [PubMed]<

2001

Degterev, A., Lugovskoy, A., Cardone, M., Mulley, B., Wagner, G., Mitchison, T., Yuan, J. (2001). Identification of small-molecule inhibitors of interaction between BH3 domain and Bcl-xL. Nat. Cell Biol. 3, 173-182. [PubMed]

Grozinger, C.M., Chao, E.D., Blackwell, H.E., Moazed, D., Schreiber, S.L. (2001). Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacteylases by phenotypic screening. J. Biol. Chem. 276, 38837-38843. [PubMed]

Pelish, H.E., Westwood, N.J., Feng, Y., Kirchhausen, T., Shair, M.D. (2001). Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product. J. Am. Chem. Soc. 123, 6740-6741. [PubMed]

Peterson, J.R., Lokey, R.S., Mitchison, T.J., Kirschner, M.W. (2001). A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc. Natl. Acad. Sci. U.S.A. 98, 10624-9. [PubMed]

2000

Haggarty, S.J., Mayer, T.U., Miyamoto, D.T., Fathi, R., King, R.W., Mitchison, T.J., Schreiber, S.L. (2000). Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chem. Biol. 7, 275-86. [PubMed]

Kapoor, T.M., Mayer, T.U., Coughlin, M.L., Mitchison, T.J. (2000). Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J. Cell. Biol. 150, 975-988. [PubMed]

Peterson, R.T., Link, B.A., Dowling, J.E., Schreiber, S.L. (2000). Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc. Natl. Acad. Sci. U.S.A. 97, 12965-12969. [PubMed]

1999

Mayer, T.U., Kapoor, T.M., Haggarty, S.J., King, R.W., Schreiber, S.L., Mitchison, T.J. (1999). Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286, 971-4. [PubMed]

Peukert, S., Jacobsen, E.N. (1999). Enantioselective parallel synthesis using polymer-supported chiral Co(salen) complexes. Org. Lett. 1(8), 1245-8. [PubMed]

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