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MitoCarta Column Documentation
| EntrezID | NCBI Entrez gene identifier |
| Symbol | Entrez official gene symbol |
| Description | Entrez gene description |
| Synonyms | Entrez gene synonyms |
| Chromosomal Location | Location of longest transcript in reference sequence mm8 or hg18 |
| Maestro Score | Integrated score of mitochondrial localization. Score of 5.45 indicates 10% cFDR cutoff, but genes with literature or GFP support may have lower scores. |
| cFDR | Estimated corrected false discovery rate associated with given Maestro score, estimated from large training datasets |
| Evidence | Evidence of mitochondrial localization:
- literature: manually curated list of genes encoding proteins with strong support of mitochondrial localization from literature (not including previous large-scale proteomic studies)
- GFP localization: clear mitochondrial localization observed by GFP-tagging and microscopy in our study
- targetP signal: mitochondrial targeting signal present in N-terminal 130 aa, based on targetP
- yeast mito homolog: best S. cerevisiase homolog, based on BlastP, is a curated mitochondrial gene
- Rickettsial homolog: mouse gene has a homolog to R. prowazekii based on BlastP with expect < 1e-3
- mito protein domain: mouse protein has a mitochondrial-specific Pfam domain
- induction: mouse transcript was induced during mitochondrial biogenesis (+ and ++ indicate higher levels of induction)
- coexpression: mouse transcript is coexpressed with known mitochondrial genes across mouse tissues (+ and ++ indicate higher levels of coexpression)
- MS/MS: mouse protein detected with high confidence in mitochondrial samples from 14 tissues (+ and ++ indicate higher confidence of detection)
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| Tissues | Protein detected by discovery MS/MS within 14 tissues analyzed:
1: cerebrum
2: cerebellem
3: brainstem
4: spinal cord
5: liver
6: kidney
7: heart
8: skeletal muscle
9: adipose
10: stomach
11: sm intestine
12: lg intestine
13: testis
14: placenta
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