MitoCarta: An Inventory of Mammalian Mitochondrial Genes

MitoCarta is an inventory of 1098 mouse genes encoding proteins with strong support of mitochondrial localization. To generate this inventory, we performed mass spectrometry of mitochondria isolated from fourteen tissues, assessed protein localization through large-scale GFP tagging/microscopy, and integrated these results with six other genome-scale datasets of mitochondrial localization, using a Bayesian approach. We also provide the inventory of 1013 human HomoloGene homologs to the mouse MitoCarta collection.

Citation: Pagliarini, D.J., Calvo, S.E., Chang, B., Sheth, S.A., Vafai, S.B., Ong, S.E., Walford, G.A., Sugiana, C., Boneh, A., Chen, W.K., et al. (2008). A mitochondrial protein compendium elucidates complex I disease biology. Cell 134, 112-123. [Pubmed: 18614015]

View MitoCarta datasets:

Mouse MitoCarta1098 MitoCarta genes: evidence of mitochondrial protein localization and protein distribution across 14 tissues
Human MitoCarta1013 MitoCarta genes: evidence of mitochondrial protein localization and protein distribution across 14 tissues
GFP localizationImages of 131 protein with mitochondrial localzation assessed by GFP tagging and microscopy

Download MitoCarta datasets:

Mouse.MitoCarta.xlsExcel database containing detailed information on the 1098 mitochondrial mouse genes, as well as integrated scores of mitochondrial localization for all ~23,000 mouse genes
Human.MitoCarta.xlsExcel database containing detailed information on the 1013 mitochondrial human genes, as well as integrated scores of mitochondrial localization for all ~17,000 human genes with well-defined mouse homologs from HomoloGene
MouseMitoCartaAll.sql
Mouse.MitoCarta.txt
MySQL database containing detailed information on the 1098 mitochondrial mouse genes, as well as integrated scores of mitochondrial localization for all ~23,000 mouse genes
HumanMitoCartaAll.sql
Human.MitoCarta.txt
MySQL database containing detailed information on the 1013 mitochondrial human genes, as well as integrated scores of mitochondrial localization for all ~17,000 human genes with well-defined mouse homologs from HomoloGene
Mouse.MitoCarta.bedBED file of mouse MitoCarta genes within UCSC mouse assembly Feb 2006 (mm8). Use UCSC's Add Custom Tracks to add URL http://www.broad.mit.edu/publications/MitoCarta/Mouse.MitoCarta.bed
Human.MitoCarta.bedBED file of human MitoCarta genes within UCSC human assembly March 2006 (hg18). Use UCSC's Add Custom Tracks to add URL http://www.broad.mit.edu/publications/MitoCarta/Human.MitoCarta.bed
Mouse.MitoCarta.fastaFasta file of mouse MitoCarta RefSeq protein sequences
Human.MitoCarta.fastaFasta file of human MitoCarta RefSeq protein sequences