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2013
MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling.Plovanich, M., Bogorad RL, Sancak Y., Kamer KJ, Strittmatter L., Li AA, Girgis HS, Kuchimanchi S., De Groot J., Speciner L., Taneja N., Oshea J., Koteliansky V., and Mootha VK PloS one, 2013/01/01, Volume 8, Issue 2, p.e55785, (2013) Read More / View Supplemental Materials
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ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans.Youngsaye, W., Hartland CL, Morgan BJ, Ting A., Nag PP, Vincent B., Mosher CA, Bittker JA, Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. Beilstein journal of organic chemistry, 2013/01/01, Volume 9, p.1501-7, (2013) Read More / View Supplemental Materials
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Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry.Gillette, MA, and Carr SA Nature methods, 2013/01/01, Volume 10, Issue 1, p.28-34, (2013) Read More / View Supplemental Materials
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Reconstructing roma history from genome-wide data.Moorjani, P., Patterson N., Loh PR, Lipson M., Kisfali P., Melegh BI, Bonin M., Kádaši L., Rieß O., Berger B., Reich D., and Melegh B. PloS one, 2013/01/01, Volume 8, Issue 3, p.e58633, (2013) Read More / View Supplemental Materials
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A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.Schroeder, FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J., Zhao WN, Reis S., Barker DD, Berry-Scott E., Kim SW, Clore EL, Hooker JM, Holson EB, Haggarty SJ, and Petryshen TL PloS one, 2013/01/01, Volume 8, Issue 8, p.e71323, (2013) Read More / View Supplemental Materials
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‘Big data’ from shrinking pathogen populations.Neafsey, DE Molecular ecology, 2013/01/01, Volume 22, Issue 2, p.271-2, (2013) Read More / View Supplemental Materials
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2012
How deep is deep enough for RNA-Seq profiling of bacterial transcriptomes?Haas, BJ, Chin M., Nusbaum C., Birren BW, and Livny J. BMC genomics, 2012/12/27, Volume 13, p.734, (2012) Read More / View Supplemental Materials
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ATARiS: Computational quantification of gene suppression phenotypes from multi-sample RNAi screens.Shao, DD, Tsherniak A., Gopal S., Weir BA, Tamayo P., Stransky N., Schumacher SE, Zack TI, Beroukhim R., Garraway LA, Margolin AA, Root DE, Hahn WC, and Mesirov J. P. Genome research, 2012/12/26, (2012) Read More / View Supplemental Materials
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Refined Preparation and Use of Anti-K- epsilon -GG Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments.Udeshi, ND, Svinkina T., Mertins P., Kuhn E., Mani D. R., Qiao JW, and Carr SA Molecular & cellular proteomics : MCP, 2012/12/24, (2012) Read More / View Supplemental Materials
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Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.Lee, MN, Roy M., Ong SE, Mertins P., Villani AC, Li W., Dotiwala F., Sen J., Doench JG, Orzalli MH, Kramnik I., Knipe DM, Lieberman J., Carr SA, and Hacohen N. Nature immunology, 2012/12/23, Volume 14, Issue 2, p.179-85, (2012) Read More / View Supplemental Materials
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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.Efeyan, A., Zoncu R., Chang S., Gumper I., Snitkin H., Wolfson RL, Kirak O., Sabatini DD, and Sabatini DM Nature, 2012/12/23, (2012) Read More / View Supplemental Materials
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β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis.Rosenbluh, J., Nijhawan D., Cox AG, Li X., Schafer EJ, Zack TI, Wang X., Tsherniak A., Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F., Cowley GS, Root DE, Mesirov J. P., Beroukhim R., and Hahn WC Cell, 2012/12/21, Volume 151, Issue 7, p.1457-73, (2012) Read More / View Supplemental Materials
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The nature of confounding in genome-wide association studies.Vilhjálmsson, BJ, and Nordborg M. Nature reviews. Genetics, 2012/12/18, Volume 14, Issue 1, p.1-2, (2012) Read More / View Supplemental Materials
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MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.Birsoy, K., Wang T., Possemato R., Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y., Peterson TR, Carette JE, Brummelkamp TR, Clish CB, and Sabatini DM Nature genetics, 2012/12/16, Volume 45, Issue 1, p.104-8, (2012) Read More / View Supplemental Materials
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Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.Barretina, J., Caponigro G., Stransky N., Venkatesan K., Margolin AA, Kim S., Wilson CJ, Lehár J., Kryukov GV, Sonkin D., Reddy A., Liu M., Murray L., Berger MF, Monahan JE, Morais P., Meltzer J., Korejwa A., Jané-Valbuena J., Mapa FA, et al. Nature, 2012/12/13, Volume 492, Issue 7428, p.290, (2012) Read More / View Supplemental Materials
The LRR and RING Domain Protein LRSAM1 Is an E3 Ligase Crucial for Ubiquitin-Dependent Autophagy of Intracellular Salmonella Typhimurium.Huett, A., Heath RJ, Begun J., Sassi SO, Baxt LA, Vyas JM, Goldberg MB, and Xavier RJ Cell host & microbe, 2012/12/13, Volume 12, Issue 6, p.778-90, (2012) Read More / View Supplemental Materials
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A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.Weïwer, M., Spoonamore J., Wei J., Guichard B., Ross NT, Masson K., Silkworth W., Dandapani S., Palmer M., Scherer CA, Stern AM, Schreiber SL, and Munoz B. ACS medicinal chemistry letters, 2012/12/13, Volume 3, Issue 12, p.1034-1038, (2012) Read More / View Supplemental Materials
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The ANK3 Bipolar Disorder Gene Regulates Psychiatric-Related Behaviors That Are Modulated by Lithium and Stress.Leussis, MP, Berry-Scott EM, Saito M., Jhuang H., De Haan G., Alkan O., Luce CJ, Madison JM, Sklar P., Serre T., Root DE, and Petryshen TL Biological psychiatry, 2012/12/10, (2012) Read More / View Supplemental Materials
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Differential analysis of gene regulation at transcript resolution with RNA-seq.Trapnell, C., Hendrickson DG, Sauvageau M., Goff L., Rinn JL, and Pachter L. Nature biotechnology, 2012/12/09, Volume 31, Issue 1, p.46-53, (2012) Read More / View Supplemental Materials
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Cellular alchemy and the golden age of reprogramming.Daley, GQ Cell, 2012/12/07, Volume 151, Issue 6, p.1151-4, (2012) Read More / View Supplemental Materials
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Differential relationship of DNA replication timing to different forms of human mutation and variation.Koren, A., Polak P., Nemesh J., Michaelson JJ, Sebat J., Sunyaev SR, and McCarroll SA American journal of human genetics, 2012/12/07, Volume 91, Issue 6, p.1033-40, (2012) Read More / View Supplemental Materials
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Disruption of a large intergenic noncoding RNA in subjects with neurodevelopmental disabilities.Talkowski, ME, Maussion G., Crapper L., Rosenfeld JA, Blumenthal I., Hanscom C., Chiang C., Lindgren A., Pereira S., Ruderfer D., Diallo AB, Lopez JP, Turecki G., Chen ES, Gigek C., Harris DJ, Lip V., An Y., Biagioli M., Macdonald ME, et al. American journal of human genetics, 2012/12/07, Volume 91, Issue 6, p.1128-34, (2012) Read More / View Supplemental Materials
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Integrative annotation of chromatin elements from ENCODE data.Hoffman, MM, Ernst J., Wilder SP, Kundaje A., Harris RS, Libbrecht M., Giardine B., Ellenbogen PM, Bilmes JA, Birney E., Hardison RC, Dunham I., Kellis M., and Noble WS Nucleic acids research, 2012/12/05, (2012) Read More / View Supplemental Materials
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Hits, leads and drugs against malaria through diversity-oriented synthesis.Dandapani, S., Comer E., Duvall JR, and Munoz B. Future medicinal chemistry, 2012/12/01, Volume 4, Issue 18, p.2279-94, (2012) Read More / View Supplemental Materials
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Targeted therapy for squamous cell lung cancer.Liao, RG, Watanabe H., Meyerson M., and Hammerman PS Lung cancer management, 2012/12/01, Volume 1, Issue 4, p.293-300, (2012) Read More / View Supplemental Materials
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Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset.Pasternak, O., Westin CF, Bouix S., Seidman LJ, Goldstein JM, Woo TU, Petryshen TL, Mesholam-Gately RI, McCarley RW, Kikinis R., Shenton ME, and Kubicki M. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012/11/28, Volume 32, Issue 48, p.17365-17372, (2012) Read More / View Supplemental Materials
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Microcephaly Gene Links Trithorax and REST/NRSF to Control Neural Stem Cell Proliferation and Differentiation.Yang, YJ, Baltus AE, Mathew RS, Murphy EA, Evrony GD, Gonzalez DM, Wang EP, Marshall-Walker CA, Barry BJ, Murn J., Tatarakis A., Mahajan MA, Samuels HH, Shi Y., Golden JA, Mahajnah M., Shenhav R., and Walsh CA Cell, 2012/11/21, Volume 151, Issue 5, p.1097-1112, (2012) Read More / View Supplemental Materials
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The Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans.Smith, JG, Avery CL, Evans DS, Nalls MA, Meng YA, Smith EN, Palmer C., Tanaka T., Mehra R., Butler AM, Young T., Buxbaum SG, Kerr KF, Berenson GS, Schnabel RB, Li G., Ellinor PT, Magnani JW, Chen W., Bis JC, et al. Circulation. Cardiovascular genetics, 2012/11/19, (2012) Read More / View Supplemental Materials
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From genetic discovery to future personalized health research.Palotie, A., Widén E., and Ripatti S. New biotechnology, 2012/11/16, (2012) Read More / View Supplemental Materials
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Expression Profiling of Archival Tumors for Long-term Health Studies.Waldron, L., Ogino S., Hoshida Y., Shima K., McCart Reed AE, Simpson PT, Baba Y., Nosho K., Segata N., Vargas AC, Cummings MC, Lakhani SR, Kirkner GJ, Giovannucci E., Quackenbush J., Golub T. R., Fuchs CS, Parmigiani G., and Huttenhower C. Clinical cancer research : an official journal of the American Association for Cancer Research, 2012/11/15, Volume 18, Issue 22, p.6136-6146, (2012) Read More / View Supplemental Materials
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Risk of Intracranial Hemorrhage With Protease-Activated Receptor-1 Antagonists.Falcone, GJ, Brouwers HB, and Rosand J. Stroke; a journal of cerebral circulation, 2012/11/15, (2012) Read More / View Supplemental Materials
Mitochondrial disorders as windows into an ancient organelle.Vafai, SB, and Mootha VK Nature, 2012/11/14, Volume 491, Issue 7424, p.374-383, (2012) Read More / View Supplemental Materials
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Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder.Lee, PH, Perlis RH, Jung JY, Byrne EM, Rueckert E., Siburian R., Haddad S., Mayerfeld CE, Heath AC, Pergadia ML, Madden PA, Boomsma DI, Penninx BW, Sklar P., Martin NG, Wray NR, Purcell SM, and Smoller JW Translational psychiatry, 2012/11/13, Volume 2, p.e184, (2012) Read More / View Supplemental Materials
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Will cholesteryl ester transfer protein inhibition succeed primarily by lowering low-density lipoprotein cholesterol?: insights from human genetics and clinical trials.Kathiresan, S. Journal of the American College of Cardiology, 2012/11/13, Volume 60, Issue 20, p.2049-52, (2012) Read More / View Supplemental Materials
Epidemiology. Emerging disease or diagnosis?Gire, SK, Stremlau M., Andersen KG, Schaffner SF, Bjornson Z., Rubins K., Hensley L., McCormick JB, Lander E. S., Garry RF, Happi C., and Sabeti PC Science (New York, N.Y.), 2012/11/09, Volume 338, Issue 6108, p.750-2, (2012) Read More / View Supplemental Materials
Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma.Jalili, A., Wagner C., Pashenkov M., Pathria G., Mertz KD, Widlund HR, Lupien M., Brunet JP, Golub T. R., Stingl G., Fisher DE, Ramaswamy S., and Wagner SN Journal of the National Cancer Institute, 2012/11/07, Volume 104, Issue 21, p.1673-9, (2012) Read More / View Supplemental Materials
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Whole Genome Pyrosequencing of Rare Hepatitis C Virus Genotypes Enhances Subtype Classification and Identification of Naturally Occurring Drug Resistance Variants.Newman, RM, Kuntzen T., Weiner B., Berical A., Charlebois P., Kuiken C., Murphy DG, Simmonds P., Bennett P., Lennon NJ, Birren BW, Zody MC, Allen TM, and Henn MR The Journal of infectious diseases, 2012/11/06, (2012) Read More / View Supplemental Materials
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Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability.Drier, Y., Lawrence MS, Carter SL, Stewart C., Gabriel SB, Lander E. S., Meyerson M., Beroukhim R., and Getz G. Genome research, 2012/11/02, (2012) Read More / View Supplemental Materials
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Bioinformatics for the human microbiome project.Gevers, D., Pop M., Schloss PD, and Huttenhower C. PLoS computational biology, 2012/11/01, Volume 8, Issue 11, p.e1002779, (2012) Read More / View Supplemental Materials
Computational analysis of noncoding RNAs.Washietl, S., Will S., Hendrix DA, Goff LA, Rinn JL, Berger B., and Kellis M. Wiley interdisciplinary reviews. RNA, 2012/11/01, Volume 3, Issue 6, p.759-78, (2012) Read More / View Supplemental Materials
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Informed conditioning on clinical covariates increases power in case-control association studies.Zaitlen, N., Lindström S., Pasaniuc B., Cornelis M., Genovese G., Pollack S., Barton A., Bickeböller H., Bowden DW, Eyre S., Freedman BI, Friedman DJ, Field JK, Groop L., Haugen A., Heinrich J., Henderson BE, Hicks PJ, Hocking LJ, Kolonel LN, et al. PLoS genetics, 2012/11/01, Volume 8, Issue 11, p.e1003032, (2012) Read More / View Supplemental Materials
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An integrated map of genetic variation from 1,092 human genomes.1000 Genomes Project, Consortium, Abecasis GR, Auton A., Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, and McVean GA Nature, 2012/11/01, Volume 491, Issue 7422, p.56-65, (2012) Read More / View Supplemental Materials
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Interpreting noncoding genetic variation in complex traits and human disease.Ward, LD, and Kellis M. Nature biotechnology, 2012/11/01, Volume 30, Issue 11, p.1095-106, (2012) Read More / View Supplemental Materials
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LINKAGE TO THE MATING-TYPE LOCUS ACROSS THE GENUS MICROBOTRYUM: INSIGHTS INTO NONRECOMBINING CHROMOSOMES.Petit, E., Giraud T., de Vienne DM, Coelho MA, Aguileta G., Amselem J., Kreplak J., Poulain J., Gavory F., Wincker P., Young SK, Cuomo C., Perlin MH, and Hood ME Evolution; international journal of organic evolution, 2012/11/01, Volume 66, Issue 11, p.3519-3533, (2012) Read More / View Supplemental Materials
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Moving toward personalized medicine in castration-resistant prostate cancer.Van Allen, EM, and Pomerantz M. The Urologic clinics of North America, 2012/11/01, Volume 39, Issue 4, p.483-90, (2012) Read More / View Supplemental Materials
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Pencil and paper.Wong, B., and Kjægaard RS Nature methods, 2012/11/01, Volume 9, Issue 11, p.1037, (2012) Read More / View Supplemental Materials
Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes.Kleinnijenhuis, J., Quintin J., Preijers F., Joosten LA, Ifrim DC, Saeed S., Jacobs C., van Loenhout J., de Jong D., Stunnenberg HG, Xavier RJ, van der Meer JW, van Crevel R., and Netea MG Proceedings of the National Academy of Sciences of the United States of America, 2012/10/23, Volume 109, Issue 43, p.17537-42, (2012) Read More / View Supplemental Materials
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Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library.Gerard, B., O'Shea MW, Donckele E., Kesavan S., Akella LB, Xu H., Jacobsen EN, and Marcaurelle LA ACS combinatorial science, 2012/10/22, (2012) Read More / View Supplemental Materials
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Oligodendrocyte Regeneration after Neonatal Hypoxia Requires FoxO1-Mediated p27Kip1 Expression.Jablonska, B., Scafidi J., Aguirre A., Vaccarino F., Nguyen V., Borok E., Horvath TL, Rowitch DH, and Gallo V. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012/10/17, Volume 32, Issue 42, p.14775-14793, (2012) Read More / View Supplemental Materials
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Integrative functional genomics identifies RINT1 as a novel GBM oncogene.Quayle, SN, Chheda MG, Shukla SA, Wiedemeyer R., Tamayo P., Dewan RW, Zhuang L., Huang-Hobbs E., Haidar S., Xiao Y., Ligon KL, Hahn WC, and Chin L. Neuro-oncology, 2012/10/16, (2012) Read More / View Supplemental Materials
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The limitations of simple gene set enrichment analysis assuming gene independence.Tamayo, P., Steinhardt G., Liberzon A., and Mesirov J. P. Statistical methods in medical research, 2012/10/14, (2012) Read More / View Supplemental Materials
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Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.Dockendorff, C., Nagiec MM, Weïwer M., Buhrlage S., Ting A., Nag PP, Germain A., Kim HJ, Youngsaye W., Scherer C., Bennion M., Xue L., Stanton BZ, Lewis TA, Macpherson L., Palmer M., Foley MA, Perez JR, and Schreiber SL ACS medicinal chemistry letters, 2012/10/11, Volume 3, Issue 10, p.808-813, (2012) Read More / View Supplemental Materials
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Revolution stalled.Hyman, SE Science translational medicine, 2012/10/10, Volume 4, Issue 155, p.155cm11, (2012) Read More / View Supplemental Materials
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Discovery and Statistical Genotyping of Copy-Number Variation from Whole-Exome Sequencing Depth.Fromer, M., Moran JL, Chambert K., Banks E., Bergen SE, Ruderfer DM, Handsaker RE, McCarroll SA, O'Donovan MC, Owen MJ, Kirov G., Sullivan PF, Hultman CM, Sklar P., and Purcell SM American journal of human genetics, 2012/10/05, Volume 91, Issue 4, p.597-607, (2012) Read More / View Supplemental Materials
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Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling.Boyle, P., Clement K., Gu H., Smith ZD, Ziller M., Fostel JL, Holmes L., Meldrim J., Kelley F., Gnirke A., and Meissner A. Genome biology, 2012/10/03, Volume 13, Issue 10, p.R92, (2012) Read More / View Supplemental Materials
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H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions.Ku, M., Jaffe JD, Koche RP, Rheinbay E., Endoh M., Koseki H., Carr SA, and Bernstein BE Genome biology, 2012/10/03, Volume 13, Issue 10, p.R85, (2012) Read More / View Supplemental Materials
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Autoimmunity: insights from human genomics.Raychaudhuri, S., and Rich SS Current opinion in immunology, 2012/10/01, Volume 24, Issue 5, p.513-5, (2012) Read More / View Supplemental Materials
Coordinating GWAS results with gene expression in a systems immunologic paradigm in autoimmunity.Stranger, BE, and De Jager PL Current opinion in immunology, 2012/10/01, Volume 24, Issue 5, p.544-51, (2012) Read More / View Supplemental Materials
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The Date of Interbreeding between Neandertals and Modern Humans.Sankararaman, S., Patterson N., Li H., Pääbo S., and Reich D. PLoS genetics, 2012/10/01, Volume 8, Issue 10, p.e1002947, (2012) Read More / View Supplemental Materials
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p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation.Conway, KL, Goel G., Sokol H., Manocha M., Mizoguchi E., Terhorst C., Bhan AK, Gardet A., and Xavier RJ Journal of immunology (Baltimore, Md. : 1950), 2012/10/01, Volume 189, Issue 7, p.3631-40, (2012) Read More / View Supplemental Materials
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Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells.Carmody, LC, Germain AR, VerPlank L., Nag PP, Muñoz B., Perez JR, and Palmer MA Journal of biomolecular screening, 2012/10/01, Volume 17, Issue 9, p.1204-10, (2012) Read More / View Supplemental Materials
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QT Interval and Long-Term Mortality Risk in the Framingham Heart Study.Noseworthy, PA, Peloso GM, Hwang SJ, Larson MG, Levy D., O'Donnell CJ, and Newton-Cheh C. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2012/10/01, Volume 17, Issue 4, p.340-348, (2012) Read More / View Supplemental Materials
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Shotgun protein sequencing with meta-contig assembly.Guthals, A., Clauser KR, and Bandeira N. Molecular & cellular proteomics : MCP, 2012/10/01, Volume 11, Issue 10, p.1084-96, (2012) Read More / View Supplemental Materials
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What have we learned from six years of GWAS in autoimmune diseases, and what is next?Hu, X., and Daly M. Current opinion in immunology, 2012/10/01, Volume 24, Issue 5, p.571-5, (2012) Read More / View Supplemental Materials
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An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.Ottoboni, L., Keenan BT, Tamayo P., Kuchroo M., Mesirov J. P., Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, and De Jager PL Science translational medicine, 2012/09/26, Volume 4, Issue 153, p.153ra131, (2012) Read More / View Supplemental Materials
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Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.Adams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/09/18, Volume 109, Issue 38, p.15115-20, (2012) Read More / View Supplemental Materials
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Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.Sankaran, VG, Ludwig LS, Sicinska E., Xu J., Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y., Orkin SH, Sicinski P., Lander E. S., and Lodish HF Genes & development, 2012/09/15, Volume 26, Issue 18, p.2075-87, (2012) Read More / View Supplemental Materials
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A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals.Garber, M., Yosef N., Goren A., Raychowdhury R., Thielke A., Guttman M., Robinson J., Minie B., Chevrier N., Itzhaki Z., Blecher-Gonen R., Bornstein C., Amann-Zalcenstein D., Weiner A., Friedrich D., Meldrim J., Ram O., Cheng C., Gnirke A., Fisher S., et al. Molecular cell, 2012/09/14, Volume 47, Issue 5, p.810-22, (2012) Read More / View Supplemental Materials
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Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.Imielinski, M., Berger AH, Hammerman PS, Hernandez B., Pugh TJ, Hodis E., Cho J., Sivachenko A., Sougnez C., Auclair D., Lawrence MS, Stojanov P., Cibulskis K., Sharifnia T., Greulich H., Banerji S., Zander T., Thompson K., Winckler W., Kwiatkowski D., et al. Cell, 2012/09/14, Volume 150, Issue 6, p.1107-20, (2012) Read More / View Supplemental Materials
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De novo assembly of highly diverse viral populations.Yang, X., Charlebois P., Gnerre S., Coole MG, Lennon NJ, Levin JZ, Qu J., Ryan EM, Zody MC, and Henn MR BMC genomics, 2012/09/13, Volume 13, p.475, (2012) Read More / View Supplemental Materials
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Integrative Analysis Reveals an Outcome-Associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B Cell Lymphoma.Monti, S., Chapuy B., Takeyama K., Rodig SJ, Hao Y., Yeda KT, Inguilizian H., Mermel C., Currie T., Dogan A., Kutok JL, Beroukhim R., Neuberg D., Habermann TM, Getz G., Kung AL, Golub T. R., and Shipp M. A. Cancer cell, 2012/09/11, Volume 22, Issue 3, p.359-72, (2012) Read More / View Supplemental Materials
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Whole Exome Sequencing Reveals a Novel Mutation in CUL7 in a Patient with an Undiagnosed Growth Disorder.Dauber, A., Stoler J., Hechter E., Safer J., and Hirschhorn JN The Journal of pediatrics, 2012/09/10, (2012) Read More / View Supplemental Materials
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Comprehensive genomic characterization of squamous cell lung cancers.The Cancer Genome Atlas Research, Network, institution.)(Participants are arranged by area of contribution and then by, Genome sequencing centres: Broad Institute, Hammerman PS, Lawrence MS, Voet D., Jing R., Cibulskis K., Sivachenko A., Stojanov P., McKenna A., Lander E. S., Gabriel S., Getz G., Sougnez C., Imielinski M., Helman E., Hernandez B., Pho NH, Meyerson M., et al. Nature, 2012/09/09, (2012) Read More / View Supplemental Materials
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Complete viral RNA genome sequencing of ultra-low copy samples by sequence-independent amplification.Malboeuf, CM, Yang X., Charlebois P., Qu J., Berlin AM, Casali M., Pesko KN, Boutwell CL, Devincenzo JP, Ebel GD, Allen TM, Zody MC, Henn MR, and Levin JZ Nucleic acids research, 2012/09/08, (2012) Read More / View Supplemental Materials
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Mechanisms and evolution of virulence in oomycetes.Jiang, RH, and Tyler BM Annual review of phytopathology, 2012/09/08, Volume 50, p.295-318, (2012) Read More / View Supplemental Materials
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Ancient Admixture in Human History.Patterson, NJ, Moorjani P., Luo Y., Mallick S., Rohland N., Zhan Y., Genschoreck T., Webster T., and Reich D. Genetics, 2012/09/07, (2012) Read More / View Supplemental Materials
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Burden of rare sarcomere gene variants in the framingham and jackson heart study cohorts.Bick, AG, Flannick J., Ito K., Cheng S., Vasan RS, Parfenov MG, Herman DS, Depalma SR, Gupta N., Gabriel SB, Funke BH, Rehm HL, Benjamin EJ, Aragam J., Taylor HA Jr, Fox ER, Newton-Cheh C., Kathiresan S., O'Donnell CJ, Wilson JG, et al. American journal of human genetics, 2012/09/07, Volume 91, Issue 3, p.513-9, (2012) Read More / View Supplemental Materials
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The first synthesis of an epidiselenodiketopiperazine.McMahon, TC, Stanley S., Kazyanskaya E., Hung D., and Wood JL Organic letters, 2012/09/07, Volume 14, Issue 17, p.4534-6, (2012) Read More / View Supplemental Materials
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Thinking inside the box: how T cell inhibitory receptors signal.Haining, WN Nature medicine, 2012/09/07, Volume 18, Issue 9, p.1338-9, (2012) Read More / View Supplemental Materials
Transcription Factor-mediated Epigenetic Reprogramming.Sindhu, C., Samavarchi-Tehrani P., and Meissner A. The Journal of biological chemistry, 2012/09/07, Volume 287, Issue 37, p.30922-31, (2012) Read More / View Supplemental Materials
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Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.Greulich, H., Kaplan B., Mertins P., Chen TH, Tanaka KE, Yun CH, Zhang X., Lee SH, Cho J., Ambrogio L., Liao R., Imielinski M., Banerji S., Berger AH, Lawrence MS, Zhang J., Pho NH, Walker SR, Winckler W., Getz G., et al. Proceedings of the National Academy of Sciences of the United States of America, 2012/09/04, Volume 109, Issue 36, p.14476-81, (2012) Read More / View Supplemental Materials
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The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum.Neafsey, DE, Galinsky K., Jiang RH, Young L., Sykes SM, Saif S., Gujja S., Goldberg JM, Young S., Zeng Q., Chapman SB, Dash AP, Anvikar AR, Sutton PL, Birren BW, Escalante AA, Barnwell JW, and Carlton JM Nature genetics, 2012/09/01, Volume 44, Issue 9, p.1046-50, (2012) Read More / View Supplemental Materials
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Mouse ooplasm confers context-specific reprogramming capacity.Chan, MM, Smith ZD, Egli D., Regev A., and Meissner A. Nature genetics, 2012/09/01, Volume 44, Issue 9, p.978-80, (2012) Read More / View Supplemental Materials
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Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.Lundby, A., Lage K., Weinert BT, Bekker-Jensen DB, Secher A., Skovgaard T., Kelstrup CD, Dmytriyev A., Choudhary C., Lundby C., and Olsen JV Cell reports, 2012/08/30, Volume 2, Issue 2, p.419-31, (2012) Read More / View Supplemental Materials
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Novel Microcephalic Primordial Dwarfism Disorder Associated with Variants in the Centrosomal Protein Ninein.Dauber, A., Lafranchi SH, Maliga Z., Lui JC, Moon JE, McDeed C., Henke K., Zonana J., Kingman GA, Pers TH, Baron J., Rosenfeld RG, Hirschhorn JN, Harris MP, and Hwa V. The Journal of clinical endocrinology and metabolism, 2012/08/29, (2012) Read More / View Supplemental Materials
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Target practice: HDAC inhibitors for schizophrenia.Hyman, SE Nature neuroscience, 2012/08/28, Volume 15, Issue 9, p.1180-1, (2012) Read More / View Supplemental Materials
DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells.Bock, C., Beerman I., Lien WH, Smith ZD, Gu H., Boyle P., Gnirke A., Fuchs E., Rossi DJ, and Meissner A. Molecular cell, 2012/08/24, Volume 47, Issue 4, p.633-47, (2012) Read More / View Supplemental Materials
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Epigenetic obstacles encountered by transcription factors: reprogramming against all odds.Gifford, CA, and Meissner A. Current opinion in genetics & development, 2012/08/23, (2012) Read More / View Supplemental Materials
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Evidence of widespread selection on standing variation in Europe at height-associated SNPs.Turchin, MC, Chiang CW, Palmer CD, Sankararaman S., Reich D., Genetic Investigation of ANthropometric Traits(GIANT) Consortium, and Hirschhorn JN Nature genetics, 2012/08/19, Volume 44, Issue 9, p.1015-9, (2012) Read More / View Supplemental Materials
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Cancer vulnerabilities unveiled by genomic loss.Nijhawan, D., Zack TI, Ren Y., Strickland MR, Lamothe R., Schumacher SE, Tsherniak A., Besche HC, Rosenbluh J., Shehata S., Cowley GS, Weir BA, Goldberg AL, Mesirov J. P., Root DE, Bhatia SN, Beroukhim R., and Hahn WC Cell, 2012/08/17, Volume 150, Issue 4, p.842-54, (2012) Read More / View Supplemental Materials
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Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.Quintin, J., Saeed S., Martens JH, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C., Jacobs L., Jansen T., Kullberg BJ, Wijmenga C., Joosten LA, Xavier RJ, van der Meer JW, Stunnenberg HG, and Netea MG Cell host & microbe, 2012/08/16, Volume 12, Issue 2, p.223-32, (2012) Read More / View Supplemental Materials
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Mild paroxysmal kinesigenic dyskinesia caused by PRRT2 missense mutation with reduced penetrance.Friedman, J., Olvera J., Silhavy JL, Gabriel SB, and Gleeson JG Neurology, 2012/08/15, (2012) Read More / View Supplemental Materials
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Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4.Ren, Y., Cheung HW, von Maltzhan G., Agrawal A., Cowley GS, Weir BA, Boehm JS, Tamayo P., Karst AM, Liu JF, Hirsch MS, Mesirov J. P., Drapkin R., Root DE, Lo J., Fogal V., Ruoslahti E., Hahn WC, and Bhatia SN Science translational medicine, 2012/08/15, Volume 4, Issue 147, p.147ra112, (2012) Read More / View Supplemental Materials
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ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.Abdel-Wahab, O., Adli M., LaFave LM, Gao J., Hricik T., Shih AH, Pandey S., Patel JP, Chung YR, Koche R., Perna F., Zhao X., Taylor JE, Park CY, Carroll M., Melnick A., Nimer SD, Jaffe JD, Aifantis I., Bernstein BE, et al. Cancer cell, 2012/08/14, Volume 22, Issue 2, p.180-93, (2012) Read More / View Supplemental Materials
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Genome-wide association study of Tourette's syndrome.Scharf, JM, Yu D., Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P., Gamazon E., Edlund CK, Service SK, Tikhomirov A., Osiecki L., Illmann C., Pluzhnikov A., Konkashbaev A., Davis LK, Han B., Crane J., Moorjani P., Crenshaw AT, et al. Molecular psychiatry, 2012/08/14, (2012) Read More / View Supplemental Materials
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Phasing of many thousands of genotyped samples.Williams, AL, Patterson N., Glessner J., Hakonarson H., and Reich D. American journal of human genetics, 2012/08/10, Volume 91, Issue 2, p.238-51, (2012) Read More / View Supplemental Materials
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Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries.Lowe, JT, Lee MD 4th, Akella LB, Davoine E., Donckele EJ, Durak L., Duvall JR, Gerard B., Holson EB, Joliton A., Kesavan S., Lemercier BC, Liu H., Marié JC, Mulrooney CA, Muncipinto G., Welzel-O'Shea M., Panko LM, Rowley A., Suh BC, et al. The Journal of organic chemistry, 2012/08/10, (2012) Read More / View Supplemental Materials
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Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.Park, DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C., Ribacke U., Van Tyne D., Galinsky K., Galligan M., Becker JS, Ndiaye D., Mboup S., Wiegand RC, Hartl DL, Sabeti PC, Wirth DF, and Volkman SK Proceedings of the National Academy of Sciences of the United States of America, 2012/08/07, Volume 109, Issue 32, p.13052-7, (2012) Read More / View Supplemental Materials
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Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.Wen, Q., Goldenson B., Silver SJ, Schenone M., Dancik V., Huang Z., Wang LZ, Lewis TA, An WF, Li X., Bray MA, Thiollier C., Diebold L., Gilles L., Vokes MS, Moore CB, Bliss-Moreau M., VerPlank L., Tolliday NJ, Mishra R., et al. Cell, 2012/08/03, Volume 150, Issue 3, p.575-89, (2012) Read More / View Supplemental Materials
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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.Pugh, TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D., Bochicchio J., Carneiro MO, Carter SL, Cibulskis K., Erlich RL, Greulich H., Lawrence MS, Lennon NJ, McKenna A., Meldrim J., Ramos AH, Ross MG, Russ C., Shefler E., Sivachenko A., et al. Nature, 2012/08/02, Volume 488, Issue 7409, p.106-10, (2012) Read More / View Supplemental Materials
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