Scientific Publications

Search by Keyword(s)
Found 1956 results

Search Results

2012
Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma.Jalili, A., Wagner C., Pashenkov M., Pathria G., Mertz KD, Widlund HR, Lupien M., Brunet JP, Golub T. R., Stingl G., Fisher DE, Ramaswamy S., and Wagner SN Journal of the National Cancer Institute, 2012/11/07, Volume 104, Issue 21, p.1673-9, (2012) Read More / View Supplemental Materials
Abstract
Whole Genome Pyrosequencing of Rare Hepatitis C Virus Genotypes Enhances Subtype Classification and Identification of Naturally Occurring Drug Resistance Variants.Newman, RM, Kuntzen T., Weiner B., Berical A., Charlebois P., Kuiken C., Murphy DG, Simmonds P., Bennett P., Lennon NJ, Birren BW, Zody MC, Allen TM, and Henn MR The Journal of infectious diseases, 2012/11/06, (2012) Read More / View Supplemental Materials
Abstract
Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability.Drier, Y., Lawrence MS, Carter SL, Stewart C., Gabriel SB, Lander E. S., Meyerson M., Beroukhim R., and Getz G. Genome research, 2012/11/02, (2012) Read More / View Supplemental Materials
Abstract
Bioinformatics for the human microbiome project.Gevers, D., Pop M., Schloss PD, and Huttenhower C. PLoS computational biology, 2012/11/01, Volume 8, Issue 11, p.e1002779, (2012) Read More / View Supplemental Materials
Computational analysis of noncoding RNAs.Washietl, S., Will S., Hendrix DA, Goff LA, Rinn JL, Berger B., and Kellis M. Wiley interdisciplinary reviews. RNA, 2012/11/01, Volume 3, Issue 6, p.759-78, (2012) Read More / View Supplemental Materials
Abstract
Informed conditioning on clinical covariates increases power in case-control association studies.Zaitlen, N., Lindström S., Pasaniuc B., Cornelis M., Genovese G., Pollack S., Barton A., Bickeböller H., Bowden DW, Eyre S., Freedman BI, Friedman DJ, Field JK, Groop L., Haugen A., Heinrich J., Henderson BE, Hicks PJ, Hocking LJ, Kolonel LN, et al. PLoS genetics, 2012/11/01, Volume 8, Issue 11, p.e1003032, (2012) Read More / View Supplemental Materials
Abstract
An integrated map of genetic variation from 1,092 human genomes.1000 Genomes Project, Consortium, Abecasis GR, Auton A., Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, and McVean GA Nature, 2012/11/01, Volume 491, Issue 7422, p.56-65, (2012) Read More / View Supplemental Materials
Abstract
Interpreting noncoding genetic variation in complex traits and human disease.Ward, LD, and Kellis M. Nature biotechnology, 2012/11/01, Volume 30, Issue 11, p.1095-106, (2012) Read More / View Supplemental Materials
Abstract
LINKAGE TO THE MATING-TYPE LOCUS ACROSS THE GENUS MICROBOTRYUM: INSIGHTS INTO NONRECOMBINING CHROMOSOMES.Petit, E., Giraud T., de Vienne DM, Coelho MA, Aguileta G., Amselem J., Kreplak J., Poulain J., Gavory F., Wincker P., Young SK, Cuomo C., Perlin MH, and Hood ME Evolution; international journal of organic evolution, 2012/11/01, Volume 66, Issue 11, p.3519-3533, (2012) Read More / View Supplemental Materials
Abstract
Moving toward personalized medicine in castration-resistant prostate cancer.Van Allen, EM, and Pomerantz M. The Urologic clinics of North America, 2012/11/01, Volume 39, Issue 4, p.483-90, (2012) Read More / View Supplemental Materials
Abstract
Pencil and paper.Wong, B., and Kjægaard RS Nature methods, 2012/11/01, Volume 9, Issue 11, p.1037, (2012) Read More / View Supplemental Materials
Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes.Kleinnijenhuis, J., Quintin J., Preijers F., Joosten LA, Ifrim DC, Saeed S., Jacobs C., van Loenhout J., de Jong D., Stunnenberg HG, Xavier RJ, van der Meer JW, van Crevel R., and Netea MG Proceedings of the National Academy of Sciences of the United States of America, 2012/10/23, Volume 109, Issue 43, p.17537-42, (2012) Read More / View Supplemental Materials
Abstract
Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library.Gerard, B., O'Shea MW, Donckele E., Kesavan S., Akella LB, Xu H., Jacobsen EN, and Marcaurelle LA ACS combinatorial science, 2012/10/22, (2012) Read More / View Supplemental Materials
Abstract
Oligodendrocyte Regeneration after Neonatal Hypoxia Requires FoxO1-Mediated p27Kip1 Expression.Jablonska, B., Scafidi J., Aguirre A., Vaccarino F., Nguyen V., Borok E., Horvath TL, Rowitch DH, and Gallo V. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012/10/17, Volume 32, Issue 42, p.14775-14793, (2012) Read More / View Supplemental Materials
Abstract
Integrative functional genomics identifies RINT1 as a novel GBM oncogene.Quayle, SN, Chheda MG, Shukla SA, Wiedemeyer R., Tamayo P., Dewan RW, Zhuang L., Huang-Hobbs E., Haidar S., Xiao Y., Ligon KL, Hahn WC, and Chin L. Neuro-oncology, 2012/10/16, (2012) Read More / View Supplemental Materials
Abstract
The limitations of simple gene set enrichment analysis assuming gene independence.Tamayo, P., Steinhardt G., Liberzon A., and Mesirov J. P. Statistical methods in medical research, 2012/10/14, (2012) Read More / View Supplemental Materials
Abstract
Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.Dockendorff, C., Nagiec MM, Weïwer M., Buhrlage S., Ting A., Nag PP, Germain A., Kim HJ, Youngsaye W., Scherer C., Bennion M., Xue L., Stanton BZ, Lewis TA, Macpherson L., Palmer M., Foley MA, Perez JR, and Schreiber SL ACS medicinal chemistry letters, 2012/10/11, Volume 3, Issue 10, p.808-813, (2012) Read More / View Supplemental Materials
Abstract
Revolution stalled.Hyman, SE Science translational medicine, 2012/10/10, Volume 4, Issue 155, p.155cm11, (2012) Read More / View Supplemental Materials
Abstract
Discovery and Statistical Genotyping of Copy-Number Variation from Whole-Exome Sequencing Depth.Fromer, M., Moran JL, Chambert K., Banks E., Bergen SE, Ruderfer DM, Handsaker RE, McCarroll SA, O'Donovan MC, Owen MJ, Kirov G., Sullivan PF, Hultman CM, Sklar P., and Purcell SM American journal of human genetics, 2012/10/05, Volume 91, Issue 4, p.597-607, (2012) Read More / View Supplemental Materials
Abstract
Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling.Boyle, P., Clement K., Gu H., Smith ZD, Ziller M., Fostel JL, Holmes L., Meldrim J., Kelley F., Gnirke A., and Meissner A. Genome biology, 2012/10/03, Volume 13, Issue 10, p.R92, (2012) Read More / View Supplemental Materials
Abstract
H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions.Ku, M., Jaffe JD, Koche RP, Rheinbay E., Endoh M., Koseki H., Carr SA, and Bernstein BE Genome biology, 2012/10/03, Volume 13, Issue 10, p.R85, (2012) Read More / View Supplemental Materials
Abstract
Autoimmunity: insights from human genomics.Raychaudhuri, S., and Rich SS Current opinion in immunology, 2012/10/01, Volume 24, Issue 5, p.513-5, (2012) Read More / View Supplemental Materials
Coordinating GWAS results with gene expression in a systems immunologic paradigm in autoimmunity.Stranger, BE, and De Jager PL Current opinion in immunology, 2012/10/01, Volume 24, Issue 5, p.544-51, (2012) Read More / View Supplemental Materials
Abstract
The Date of Interbreeding between Neandertals and Modern Humans.Sankararaman, S., Patterson N., Li H., Pääbo S., and Reich D. PLoS genetics, 2012/10/01, Volume 8, Issue 10, p.e1002947, (2012) Read More / View Supplemental Materials
Abstract
p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation.Conway, KL, Goel G., Sokol H., Manocha M., Mizoguchi E., Terhorst C., Bhan AK, Gardet A., and Xavier RJ Journal of immunology (Baltimore, Md. : 1950), 2012/10/01, Volume 189, Issue 7, p.3631-40, (2012) Read More / View Supplemental Materials
Abstract
Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells.Carmody, LC, Germain AR, VerPlank L., Nag PP, Muñoz B., Perez JR, and Palmer MA Journal of biomolecular screening, 2012/10/01, Volume 17, Issue 9, p.1204-10, (2012) Read More / View Supplemental Materials
Abstract
QT Interval and Long-Term Mortality Risk in the Framingham Heart Study.Noseworthy, PA, Peloso GM, Hwang SJ, Larson MG, Levy D., O'Donnell CJ, and Newton-Cheh C. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2012/10/01, Volume 17, Issue 4, p.340-348, (2012) Read More / View Supplemental Materials
Abstract
Shotgun protein sequencing with meta-contig assembly.Guthals, A., Clauser KR, and Bandeira N. Molecular & cellular proteomics : MCP, 2012/10/01, Volume 11, Issue 10, p.1084-96, (2012) Read More / View Supplemental Materials
Abstract
What have we learned from six years of GWAS in autoimmune diseases, and what is next?Hu, X., and Daly M. Current opinion in immunology, 2012/10/01, Volume 24, Issue 5, p.571-5, (2012) Read More / View Supplemental Materials
Abstract
An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.Ottoboni, L., Keenan BT, Tamayo P., Kuchroo M., Mesirov J. P., Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, and De Jager PL Science translational medicine, 2012/09/26, Volume 4, Issue 153, p.153ra131, (2012) Read More / View Supplemental Materials
Abstract
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.Adams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/09/18, Volume 109, Issue 38, p.15115-20, (2012) Read More / View Supplemental Materials
Abstract
Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.Sankaran, VG, Ludwig LS, Sicinska E., Xu J., Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y., Orkin SH, Sicinski P., Lander E. S., and Lodish HF Genes & development, 2012/09/15, Volume 26, Issue 18, p.2075-87, (2012) Read More / View Supplemental Materials
Abstract
A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals.Garber, M., Yosef N., Goren A., Raychowdhury R., Thielke A., Guttman M., Robinson J., Minie B., Chevrier N., Itzhaki Z., Blecher-Gonen R., Bornstein C., Amann-Zalcenstein D., Weiner A., Friedrich D., Meldrim J., Ram O., Cheng C., Gnirke A., Fisher S., et al. Molecular cell, 2012/09/14, Volume 47, Issue 5, p.810-22, (2012) Read More / View Supplemental Materials
Abstract
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.Imielinski, M., Berger AH, Hammerman PS, Hernandez B., Pugh TJ, Hodis E., Cho J., Sivachenko A., Sougnez C., Auclair D., Lawrence MS, Stojanov P., Cibulskis K., Sharifnia T., Greulich H., Banerji S., Zander T., Thompson K., Winckler W., Kwiatkowski D., et al. Cell, 2012/09/14, Volume 150, Issue 6, p.1107-20, (2012) Read More / View Supplemental Materials
Abstract
De novo assembly of highly diverse viral populations.Yang, X., Charlebois P., Gnerre S., Coole MG, Lennon NJ, Levin JZ, Qu J., Ryan EM, Zody MC, and Henn MR BMC genomics, 2012/09/13, Volume 13, p.475, (2012) Read More / View Supplemental Materials
Abstract
Integrative Analysis Reveals an Outcome-Associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B Cell Lymphoma.Monti, S., Chapuy B., Takeyama K., Rodig SJ, Hao Y., Yeda KT, Inguilizian H., Mermel C., Currie T., Dogan A., Kutok JL, Beroukhim R., Neuberg D., Habermann TM, Getz G., Kung AL, Golub T. R., and Shipp M. A. Cancer cell, 2012/09/11, Volume 22, Issue 3, p.359-72, (2012) Read More / View Supplemental Materials
Abstract
Whole Exome Sequencing Reveals a Novel Mutation in CUL7 in a Patient with an Undiagnosed Growth Disorder.Dauber, A., Stoler J., Hechter E., Safer J., and Hirschhorn JN The Journal of pediatrics, 2012/09/10, (2012) Read More / View Supplemental Materials
Abstract
Comprehensive genomic characterization of squamous cell lung cancers.The Cancer Genome Atlas Research, Network, institution.)(Participants are arranged by area of contribution and then by, Genome sequencing centres: Broad Institute, Hammerman PS, Lawrence MS, Voet D., Jing R., Cibulskis K., Sivachenko A., Stojanov P., McKenna A., Lander E. S., Gabriel S., Getz G., Sougnez C., Imielinski M., Helman E., Hernandez B., Pho NH, Meyerson M., et al. Nature, 2012/09/09, (2012) Read More / View Supplemental Materials
Abstract
Complete viral RNA genome sequencing of ultra-low copy samples by sequence-independent amplification.Malboeuf, CM, Yang X., Charlebois P., Qu J., Berlin AM, Casali M., Pesko KN, Boutwell CL, Devincenzo JP, Ebel GD, Allen TM, Zody MC, Henn MR, and Levin JZ Nucleic acids research, 2012/09/08, (2012) Read More / View Supplemental Materials
Abstract
Mechanisms and evolution of virulence in oomycetes.Jiang, RH, and Tyler BM Annual review of phytopathology, 2012/09/08, Volume 50, p.295-318, (2012) Read More / View Supplemental Materials
Abstract
Ancient Admixture in Human History.Patterson, NJ, Moorjani P., Luo Y., Mallick S., Rohland N., Zhan Y., Genschoreck T., Webster T., and Reich D. Genetics, 2012/09/07, (2012) Read More / View Supplemental Materials
Abstract
Burden of rare sarcomere gene variants in the framingham and jackson heart study cohorts.Bick, AG, Flannick J., Ito K., Cheng S., Vasan RS, Parfenov MG, Herman DS, Depalma SR, Gupta N., Gabriel SB, Funke BH, Rehm HL, Benjamin EJ, Aragam J., Taylor HA Jr, Fox ER, Newton-Cheh C., Kathiresan S., O'Donnell CJ, Wilson JG, et al. American journal of human genetics, 2012/09/07, Volume 91, Issue 3, p.513-9, (2012) Read More / View Supplemental Materials
Abstract
The first synthesis of an epidiselenodiketopiperazine.McMahon, TC, Stanley S., Kazyanskaya E., Hung D., and Wood JL Organic letters, 2012/09/07, Volume 14, Issue 17, p.4534-6, (2012) Read More / View Supplemental Materials
Abstract
Thinking inside the box: how T cell inhibitory receptors signal.Haining, WN Nature medicine, 2012/09/07, Volume 18, Issue 9, p.1338-9, (2012) Read More / View Supplemental Materials
Transcription Factor-mediated Epigenetic Reprogramming.Sindhu, C., Samavarchi-Tehrani P., and Meissner A. The Journal of biological chemistry, 2012/09/07, Volume 287, Issue 37, p.30922-31, (2012) Read More / View Supplemental Materials
Abstract
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.Greulich, H., Kaplan B., Mertins P., Chen TH, Tanaka KE, Yun CH, Zhang X., Lee SH, Cho J., Ambrogio L., Liao R., Imielinski M., Banerji S., Berger AH, Lawrence MS, Zhang J., Pho NH, Walker SR, Winckler W., Getz G., et al. Proceedings of the National Academy of Sciences of the United States of America, 2012/09/04, Volume 109, Issue 36, p.14476-81, (2012) Read More / View Supplemental Materials
Abstract
The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum.Neafsey, DE, Galinsky K., Jiang RH, Young L., Sykes SM, Saif S., Gujja S., Goldberg JM, Young S., Zeng Q., Chapman SB, Dash AP, Anvikar AR, Sutton PL, Birren BW, Escalante AA, Barnwell JW, and Carlton JM Nature genetics, 2012/09/01, Volume 44, Issue 9, p.1046-50, (2012) Read More / View Supplemental Materials
Abstract
Mouse ooplasm confers context-specific reprogramming capacity.Chan, MM, Smith ZD, Egli D., Regev A., and Meissner A. Nature genetics, 2012/09/01, Volume 44, Issue 9, p.978-80, (2012) Read More / View Supplemental Materials
Abstract
Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.Lundby, A., Lage K., Weinert BT, Bekker-Jensen DB, Secher A., Skovgaard T., Kelstrup CD, Dmytriyev A., Choudhary C., Lundby C., and Olsen JV Cell reports, 2012/08/30, Volume 2, Issue 2, p.419-31, (2012) Read More / View Supplemental Materials
Abstract
Novel Microcephalic Primordial Dwarfism Disorder Associated with Variants in the Centrosomal Protein Ninein.Dauber, A., Lafranchi SH, Maliga Z., Lui JC, Moon JE, McDeed C., Henke K., Zonana J., Kingman GA, Pers TH, Baron J., Rosenfeld RG, Hirschhorn JN, Harris MP, and Hwa V. The Journal of clinical endocrinology and metabolism, 2012/08/29, (2012) Read More / View Supplemental Materials
Abstract
Target practice: HDAC inhibitors for schizophrenia.Hyman, SE Nature neuroscience, 2012/08/28, Volume 15, Issue 9, p.1180-1, (2012) Read More / View Supplemental Materials
DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells.Bock, C., Beerman I., Lien WH, Smith ZD, Gu H., Boyle P., Gnirke A., Fuchs E., Rossi DJ, and Meissner A. Molecular cell, 2012/08/24, Volume 47, Issue 4, p.633-47, (2012) Read More / View Supplemental Materials
Abstract
Epigenetic obstacles encountered by transcription factors: reprogramming against all odds.Gifford, CA, and Meissner A. Current opinion in genetics & development, 2012/08/23, (2012) Read More / View Supplemental Materials
Abstract
Evidence of widespread selection on standing variation in Europe at height-associated SNPs.Turchin, MC, Chiang CW, Palmer CD, Sankararaman S., Reich D., Genetic Investigation of ANthropometric Traits(GIANT) Consortium, and Hirschhorn JN Nature genetics, 2012/08/19, Volume 44, Issue 9, p.1015-9, (2012) Read More / View Supplemental Materials
Abstract
Cancer vulnerabilities unveiled by genomic loss.Nijhawan, D., Zack TI, Ren Y., Strickland MR, Lamothe R., Schumacher SE, Tsherniak A., Besche HC, Rosenbluh J., Shehata S., Cowley GS, Weir BA, Goldberg AL, Mesirov J. P., Root DE, Bhatia SN, Beroukhim R., and Hahn WC Cell, 2012/08/17, Volume 150, Issue 4, p.842-54, (2012) Read More / View Supplemental Materials
Abstract
Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.Quintin, J., Saeed S., Martens JH, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C., Jacobs L., Jansen T., Kullberg BJ, Wijmenga C., Joosten LA, Xavier RJ, van der Meer JW, Stunnenberg HG, and Netea MG Cell host & microbe, 2012/08/16, Volume 12, Issue 2, p.223-32, (2012) Read More / View Supplemental Materials
Abstract
Mild paroxysmal kinesigenic dyskinesia caused by PRRT2 missense mutation with reduced penetrance.Friedman, J., Olvera J., Silhavy JL, Gabriel SB, and Gleeson JG Neurology, 2012/08/15, (2012) Read More / View Supplemental Materials
Abstract
Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4.Ren, Y., Cheung HW, von Maltzhan G., Agrawal A., Cowley GS, Weir BA, Boehm JS, Tamayo P., Karst AM, Liu JF, Hirsch MS, Mesirov J. P., Drapkin R., Root DE, Lo J., Fogal V., Ruoslahti E., Hahn WC, and Bhatia SN Science translational medicine, 2012/08/15, Volume 4, Issue 147, p.147ra112, (2012) Read More / View Supplemental Materials
Abstract
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.Abdel-Wahab, O., Adli M., LaFave LM, Gao J., Hricik T., Shih AH, Pandey S., Patel JP, Chung YR, Koche R., Perna F., Zhao X., Taylor JE, Park CY, Carroll M., Melnick A., Nimer SD, Jaffe JD, Aifantis I., Bernstein BE, et al. Cancer cell, 2012/08/14, Volume 22, Issue 2, p.180-93, (2012) Read More / View Supplemental Materials
Abstract
Genome-wide association study of Tourette's syndrome.Scharf, JM, Yu D., Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P., Gamazon E., Edlund CK, Service SK, Tikhomirov A., Osiecki L., Illmann C., Pluzhnikov A., Konkashbaev A., Davis LK, Han B., Crane J., Moorjani P., Crenshaw AT, et al. Molecular psychiatry, 2012/08/14, (2012) Read More / View Supplemental Materials
Abstract
Phasing of many thousands of genotyped samples.Williams, AL, Patterson N., Glessner J., Hakonarson H., and Reich D. American journal of human genetics, 2012/08/10, Volume 91, Issue 2, p.238-51, (2012) Read More / View Supplemental Materials
Abstract
Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries.Lowe, JT, Lee MD 4th, Akella LB, Davoine E., Donckele EJ, Durak L., Duvall JR, Gerard B., Holson EB, Joliton A., Kesavan S., Lemercier BC, Liu H., Marié JC, Mulrooney CA, Muncipinto G., Welzel-O'Shea M., Panko LM, Rowley A., Suh BC, et al. The Journal of organic chemistry, 2012/08/10, (2012) Read More / View Supplemental Materials
Abstract
Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.Park, DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C., Ribacke U., Van Tyne D., Galinsky K., Galligan M., Becker JS, Ndiaye D., Mboup S., Wiegand RC, Hartl DL, Sabeti PC, Wirth DF, and Volkman SK Proceedings of the National Academy of Sciences of the United States of America, 2012/08/07, Volume 109, Issue 32, p.13052-7, (2012) Read More / View Supplemental Materials
Abstract
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.Wen, Q., Goldenson B., Silver SJ, Schenone M., Dancik V., Huang Z., Wang LZ, Lewis TA, An WF, Li X., Bray MA, Thiollier C., Diebold L., Gilles L., Vokes MS, Moore CB, Bliss-Moreau M., VerPlank L., Tolliday NJ, Mishra R., et al. Cell, 2012/08/03, Volume 150, Issue 3, p.575-89, (2012) Read More / View Supplemental Materials
Abstract
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.Pugh, TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D., Bochicchio J., Carneiro MO, Carter SL, Cibulskis K., Erlich RL, Greulich H., Lawrence MS, Lennon NJ, McKenna A., Meldrim J., Ramos AH, Ross MG, Russ C., Shefler E., Sivachenko A., et al. Nature, 2012/08/02, Volume 488, Issue 7409, p.106-10, (2012) Read More / View Supplemental Materials
Abstract
The human microbiome project: a community resource for the healthy human microbiome.Gevers, D., Knight R., Petrosino JF, Huang K., McGuire AL, Birren BW, Nelson KE, White O., Methé BA, and Huttenhower C. PLoS biology, 2012/08/01, Volume 10, Issue 8, p.e1001377, (2012) Read More / View Supplemental Materials
Abstract
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits.Voight, BF, Kang HM, Ding J., Palmer CD, Sidore C., Chines PS, Burtt NP, Fuchsberger C., Li Y., Erdmann J., Frayling TM, Heid IM, Jackson AU, Johnson T., Kilpeläinen TO, Lindgren CM, Morris AP, Prokopenko I., Randall JC, Saxena R., et al. PLoS genetics, 2012/08/01, Volume 8, Issue 8, p.e1002793, (2012) Read More / View Supplemental Materials
Abstract
Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder.Rueckert, EH, Barker D., Ruderfer D., Bergen SE, O'Dushlaine C., Luce CJ, Sheridan SD, Theriault KM, Chambert K., Moran J., Purcell SM, Madison JM, Haggarty SJ, and Sklar P. Molecular psychiatry, 2012/07/31, (2012) Read More / View Supplemental Materials
Abstract
Novel, panzootic and hybrid genotypes of amphibian chytridiomycosis associated with the bullfrog trade.Schloegel, LM, Toledo LF, Longcore JE, Greenspan SE, Vieira CA, Lee M., Zhao S., Wangen C., Ferreira CM, Hipolito M., Davies AJ, Cuomo CA, Daszak P., and James TY Molecular ecology, 2012/07/31, (2012) Read More / View Supplemental Materials
Abstract
Resistance to EGFR blockade in colorectal cancer: liquid biopsies and latent subclones.Konieczkowski, DJ, and Garraway LA Cell research, 2012/07/31, (2012) Read More / View Supplemental Materials
Abstract
New mechanisms of 5-nitrofuran toxicity.Peterson, RT Chemistry & biology, 2012/07/27, Volume 19, Issue 7, p.789-90, (2012) Read More / View Supplemental Materials
Abstract
zCall: A Rare Variant Caller for Array-based Genotyping.Goldstein, JI, Crenshaw A., Carey J., Grant G., Maguire J., Fromer M., O'Dushlaine C., Moran JL, Chambert K., Stevens C., Swedish Schizophrenia Consortium, ARRA Autism Sequencing Consortium, Sklar P., Hultman CM, Purcell S., McCarroll S., Sullivan PF, Daly M. J., and Neale BM Bioinformatics (Oxford, England), 2012/07/27, (2012) Read More / View Supplemental Materials
Abstract
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains.Cong, L., Zhou R., Kuo YC, Cunniff M., and Zhang F. Nature communications, 2012/07/24, Volume 3, p.968, (2012) Read More / View Supplemental Materials
Abstract
Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.Grant, SS, Kaufmann BB, Chand NS, Haseley N., and Hung DT Proceedings of the National Academy of Sciences of the United States of America, 2012/07/24, Volume 109, Issue 30, p.12147-52, (2012) Read More / View Supplemental Materials
Abstract
Finished bacterial genomes from shotgun sequence data.Ribeiro, F., Przybylski D., Yin S., Sharpe T., Gnerre S., Abouelleil A., Berlin AM, Montmayeur A., Shea TP, Walker BJ, Young SK, Russ C., Maccallum I., Nusbaum C., and Jaffe DB Genome research, 2012/07/24, (2012) Read More / View Supplemental Materials
Abstract
Concordance and Discordance in Tumor Genomic Profiling.Garraway, LA Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012/07/23, (2012) Read More / View Supplemental Materials
A landscape of driver mutations in melanoma.Hodis, E., Watson IR, Kryukov GV, Arold ST, Imielinski M., Theurillat JP, Nickerson E., Auclair D., Li L., Place C., Dicara D., Ramos AH, Lawrence MS, Cibulskis K., Sivachenko A., Voet D., Saksena G., Stransky N., Onofrio RC, Winckler W., et al. Cell, 2012/07/20, Volume 150, Issue 2, p.251-63, (2012) Read More / View Supplemental Materials
Abstract
Microsporidian genome analysis reveals evolutionary strategies for obligate intracellular growth.Cuomo, CA, Desjardins CA, Bakowski MA, Goldberg J., Ma AT, Becnel JJ, Didier ES, Fan L., Heiman DI, Levin JZ, Young S., Zeng Q., and Troemel ER Genome research, 2012/07/18, (2012) Read More / View Supplemental Materials
Abstract
Paired-end sequencing of Fosmid libraries by Illumina.Williams, LJ, Tabbaa DG, Li N., Berlin AM, Shea TP, Maccallum I., Lawrence MS, Drier Y., Getz G., Young SK, Jaffe DB, Nusbaum C., and Gnirke A. Genome research, 2012/07/17, (2012) Read More / View Supplemental Materials
Abstract
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers.Lee, RS, Stewart C., Carter SL, Ambrogio L., Cibulskis K., Sougnez C., Lawrence MS, Auclair D., Mora J., Golub T. R., Biegel JA, Getz G., and Roberts CW The Journal of clinical investigation, 2012/07/16, (2012) Read More / View Supplemental Materials
Abstract
Wisdom of crowds for robust gene network inference.Marbach, D., Costello JC, Küffner R., Vega NM, Prill RJ, Camacho DM, Allison KR, The DREAM5 Consortium, Aderhold A., Allison KR, Bonneau R., Camacho DM, Chen Y., Collins JJ, Cordero F., Costello JC, Crane M., Dondelinger F., Drton M., Esposito R., et al. Nature methods, 2012/07/15, (2012) Read More / View Supplemental Materials
Abstract
Reconstructing Native American population history.Reich, D., Patterson N., Campbell D., Tandon A., Mazieres S., Ray N., Parra MV, Rojas W., Duque C., Mesa N., García LF, Triana O., Blair S., Maestre A., Dib JC, Bravi CM, Bailliet G., Corach D., Hünemeier T., Bortolini MC, et al. Nature, 2012/07/11, (2012) Read More / View Supplemental Materials
Abstract
Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson.Birsoy, K., Sabatini DM, and Possemato R. Nature medicine, 2012/07/06, Volume 18, Issue 7, p.1022-3, (2012) Read More / View Supplemental Materials
Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.Fass, DM, Reis SA, Ghosh B., Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Groves Kuhnle CE, Tang W., Barker DD, Mazitschek R., Schreiber SL, Tsai LH, and Haggarty SJ Neuropharmacology, 2012/07/04, (2012) Read More / View Supplemental Materials
Abstract
Strain-Specific Regulation of Striatal Phenotype in Drd2-eGFP BAC Transgenic Mice.Chan, CS, Peterson JD, Gertler TS, Glajch KE, Quintana RE, Cui Q., Sebel LE, Plotkin JL, Shen W., Heiman M., Heintz N., Greengard P., and Surmeier DJ The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012/07/04, Volume 32, Issue 27, p.9124-9132, (2012) Read More / View Supplemental Materials
Abstract
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.Straussman, R., Morikawa T., Shee K., Barzily-Rokni M., Qian ZR, Du J., Davis A., Mongare MM, Gould J., Frederick DT, Cooper ZA, Chapman PB, Solit DB, Ribas A., Lo RS, Flaherty KT, Ogino S., Wargo JA, and Golub T. R. Nature, 2012/07/04, (2012) Read More / View Supplemental Materials
Abstract
Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia.Sankaran, VG, Ghazvinian R., Do R., Thiru P., Vergilio JA, Beggs AH, Sieff CA, Orkin SH, Nathan DG, Lander E. S., and Gazda HT The Journal of clinical investigation, 2012/07/02, Volume 122, Issue 7, p.2439-43, (2012) Read More / View Supplemental Materials
Abstract
Efficiency and power as a function of sequence coverage, SNP array density, and imputation.Flannick, J., Korn JM, Fontanillas P., Grant GB, Banks E., DePristo MA, and Altshuler D. PLoS computational biology, 2012/07/01, Volume 8, Issue 7, p.e1002604, (2012) Read More / View Supplemental Materials
Abstract
Structural haplotypes and recent evolution of the human 17q21.31 region.Boettger, LM, Handsaker RE, Zody MC, and McCarroll SA Nature genetics, 2012/07/01, (2012) Read More / View Supplemental Materials
Abstract
The uncertain road towards genomic medicine.Macarthur, DG, and Lek M. Trends in genetics : TIG, 2012/07/01, Volume 28, Issue 7, p.303-5, (2012) Read More / View Supplemental Materials
Abstract
Annotated high-throughput microscopy image sets for validation.Ljosa, V., Sokolnicki KL, and Carpenter AE Nature methods, 2012/06/28, Volume 9, Issue 7, p.637, (2012) Read More / View Supplemental Materials
A call for bioimaging software usability.Carpenter, AE, Kamentsky L., and Eliceiri KW Nature methods, 2012/06/28, Volume 9, Issue 7, p.666-70, (2012) Read More / View Supplemental Materials
Amino acids and mTORC1: from lysosomes to disease.Efeyan, A., Zoncu R., and Sabatini DM Trends in molecular medicine, 2012/06/27, (2012) Read More / View Supplemental Materials
Abstract
Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers.Briggs, AW, Rios X., Chari R., Yang L., Zhang F., Mali P., and Church GM Nucleic acids research, 2012/06/26, (2012) Read More / View Supplemental Materials
Abstract
Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population.Chang, HH, Park DJ, Galinsky KJ, Schaffner SF, Ndiaye D., Ndir O., Mboup S., Wiegand RC, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, and Hartl DL Molecular biology and evolution, 2012/06/24, (2012) Read More / View Supplemental Materials
Abstract
Inhibition of histone deacetylase 3 protects Beta cells from cytokine-induced apoptosis.Chou, DH, Holson EB, Wagner FF, Tang AJ, Maglathlin RL, Lewis TA, Schreiber SL, and Wagner BK Chemistry & biology, 2012/06/22, Volume 19, Issue 6, p.669-73, (2012) Read More / View Supplemental Materials
Abstract
Sequence analysis of mutations and translocations across breast cancer subtypes.Banerji, S., Cibulskis K., Rangel-Escareno C., Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C., Zou L., Cortes ML, Fernandez-Lopez JC, Peng S., Ardlie KG, Auclair D., Bautista-Piña V., Duke F., Francis J., Jung J., Maffuz-Aziz A., et al. Nature, 2012/06/20, Volume 486, Issue 7403, p.405-9, (2012) Read More / View Supplemental Materials
Abstract
Activity-dependent A-to-I RNA Editing in Rat Cortical Neurons.Sanjana, NE, Levanon EY, Hueske EA, Ambrose JM, and Li JB Genetics, 2012/06/19, (2012) Read More / View Supplemental Materials
Abstract
Efficient algorithms for the reconciliation problem with gene duplication, horizontal transfer and loss.Bansal, MS, Alm EJ, and Kellis M. Bioinformatics (Oxford, England), 2012/06/15, Volume 28, Issue 12, p.i283-i291, (2012) Read More / View Supplemental Materials
Abstract
The promise and perils of stem cell therapeutics.Daley, GQ Cell stem cell, 2012/06/14, Volume 10, Issue 6, p.740-9, (2012) Read More / View Supplemental Materials
Abstract