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2012
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.Barbieri, CE, Baca SC, Lawrence MS, Demichelis F., Blattner M., Theurillat JP, White TA, Stojanov P., Van Allen E., Stransky N., Nickerson E., Chae SS, Boysen G., Auclair D., Onofrio RC, Park K., Kitabayashi N., MacDonald TY, Sheikh K., Vuong T., et al. Nature genetics, 2012/05/20, Volume 44, Issue 6, p.685-9, (2012) Read More / View Supplemental Materials
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Extremely low-coverage sequencing and imputation increases power for genome-wide association studies.Pasaniuc, B., Rohland N., McLaren PJ, Garimella K., Zaitlen N., Li H., Gupta N., Neale BM, Daly M. J., Sklar P., Sullivan PF, Bergen S., Moran JL, Hultman CM, Lichtenstein P., Magnusson P., Purcell SM, Haas DW, Liang L., Sunyaev S., et al. Nature genetics, 2012/05/20, Volume 44, Issue 6, p.631-5, (2012) Read More / View Supplemental Materials
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mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.Yilmaz, OH, Katajisto P., Lamming DW, Gültekin Y., Bauer-Rowe KE, Sengupta S., Birsoy K., Dursun A., Yilmaz VO, Selig M., Nielsen GP, Mino-Kenudson M., Zukerberg LR, Bhan AK, Deshpande V., and Sabatini DM Nature, 2012/05/20, (2012) Read More / View Supplemental Materials
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Evolutionary diversity of the mitochondrial calcium uniporter.Bick, AG, Calvo SE, and Mootha VK Science (New York, N.Y.), 2012/05/18, Volume 336, Issue 6083, p.886, (2012) Read More / View Supplemental Materials
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Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.Voight, BF, Peloso GM, Orho-Melander M., Frikke-Schmidt R., Barbalic M., Jensen MK, Hindy G., Hólm H., Ding EL, Johnson T., Schunkert H., Samani NJ, Clarke R., Hopewell JC, Thompson JF, Li M., Thorleifsson G., Newton-Cheh C., Musunuru K., Pirruccello JP, et al. Lancet, 2012/05/17, (2012) Read More / View Supplemental Materials
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Identification of a selective small molecule inhibitor of breast cancer stem cells.Germain, AR, Carmody LC, Morgan B., Fernandez C., Forbeck E., Lewis TA, Nag PP, Ting A., VerPlank L., Feng Y., Perez JR, Dandapani S., Palmer M., Lander E. S., Gupta PB, Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2012/05/15, Volume 22, Issue 10, p.3571-4, (2012) Read More / View Supplemental Materials
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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Manning, AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N., Chen H., Rybin D., Liu CT, Bielak LF, Prokopenko I., Amin N., Barnes D., Cadby G., Hottenga JJ, Ingelsson E., Jackson AU, Johnson T., Kanoni S., Ladenvall C., Lagou V., et al. Nature genetics, 2012/05/13, Volume 44, Issue 6, p.659-669, (2012) Read More / View Supplemental Materials
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Melanoma genome sequencing reveals frequent PREX2 mutations.Berger, MF, Hodis E., Heffernan TP, Deribe YL, Lawrence MS, Protopopov A., Ivanova E., Watson IR, Nickerson E., Ghosh P., Zhang H., Zeid R., Ren X., Cibulskis K., Sivachenko AY, Wagle N., Sucker A., Sougnez C., Onofrio R., Ambrogio L., et al. Nature, 2012/05/09, Volume 485, Issue 7399, p.502-6, (2012) Read More / View Supplemental Materials
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Apoptotic Cells Are Cleared by Directional Migration and elmo1- Dependent Macrophage Engulfment.van Ham, TJ, Kokel D., and Peterson RT Current biology : CB, 2012/05/08, Volume 22, Issue 9, p.830-6, (2012) Read More / View Supplemental Materials
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Exploring single-sample SNP and INDEL calling with whole-genome de novo assembly.Li, H. Bioinformatics (Oxford, England), 2012/05/07, (2012) Read More / View Supplemental Materials
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A Method of Moments Estimator for Random Effect Multivariate Meta-Analysis.Chen, H., Manning AK, and Dupuis J. Biometrics, 2012/05/02, (2012) Read More / View Supplemental Materials
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Expression of the p53 Target CDIP Correlates with Sensitivity to TNFα-Induced Apoptosis in Cancer Cells.Brown-Endres, L., Schoenfeld D., Tian F., Kim HG, Namba T., Muñoz-Fontela C., Mandinova A., Aaronson SA, and Lee SW Cancer research, 2012/05/01, Volume 72, Issue 9, p.2373-82, (2012) Read More / View Supplemental Materials
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Modification site localization scoring: strategies and performance.Chalkley, RJ, and Clauser KR Molecular & cellular proteomics : MCP, 2012/05/01, Volume 11, Issue 5, p.3-14, (2012) Read More / View Supplemental Materials
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Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.Youngsaye, W., Dockendorff C., Vincent B., Hartland CL, Bittker JA, Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2012/05/01, Volume 22, Issue 9, p.3362-5, (2012) Read More / View Supplemental Materials
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A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma.Yuan, Y., Wang Q., Paulk J., Kubicek S., Kemp MM, Adams DJ, Shamji AF, Wagner BK, and Schreiber SL ACS chemical biology, 2012/04/30, (2012) Read More / View Supplemental Materials
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Absolute quantification of somatic DNA alterations in human cancer.Carter, SL, Cibulskis K., Helman E., McKenna A., Shen H., Zack T., Laird PW, Onofrio RC, Winckler W., Weir BA, Beroukhim R., Pellman D., Levine DA, Lander E. S., Meyerson M., and Getz G. Nature biotechnology, 2012/04/29, (2012) Read More / View Supplemental Materials
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Reduced Expression of Ribosomal Proteins Relieves MicroRNA-Mediated Repression.Janas, MM, Wang E., Love T., Harris AS, Stevenson K., Semmelmann K., Shaffer JM, Chen PH, Doench JG, Yerramilli SV, Neuberg DS, Iliopoulos D., Housman DE, Burge CB, and Novina CD Molecular cell, 2012/04/27, Volume 46, Issue 2, p.171-86, (2012) Read More / View Supplemental Materials
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Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries.Talkowski, ME, Rosenfeld JA, Blumenthal I., Pillalamarri V., Chiang C., Heilbut A., Ernst C., Hanscom C., Rossin E., Lindgren AM, Pereira S., Ruderfer D., Kirby A., Ripke S., Harris DJ, Lee JH, Ha K., Kim HG, Solomon BD, Gropman AL, et al. Cell, 2012/04/27, Volume 149, Issue 3, p.525-37, (2012) Read More / View Supplemental Materials
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Apolipoprotein E Genotype Predicts Hematoma Expansion in Lobar Intracerebral Hemorrhage.Brouwers, HB, Biffi A., Ayres AM, Schwab K., Cortellini L., Romero JM, Rost NS, Viswanathan A., Greenberg SM, Rosand J., and Goldstein JN Stroke; a journal of cerebral circulation, 2012/04/24, (2012) Read More / View Supplemental Materials
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Sex-specific influence of DRD2 on ADHD-type temperament in a large population-based birth cohort.Nyman, ES, Loukola A., Varilo T., Taanila A., Hurtig T., Moilanen I., Loo S., McGough JJ, Järvelin MR, Smalley SL, Nelson SF, and Peltonen L. Psychiatric genetics, 2012/04/23, (2012) Read More / View Supplemental Materials
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An image analysis toolbox for high-throughput C. elegans assays.Wählby, C., Kamentsky L., Liu ZH, Riklin-Raviv T., Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O., Ljosa V., Irazoqui JE, Golland P., Ruvkun G., Ausubel FM, and Carpenter AE Nature methods, 2012/04/22, (2012) Read More / View Supplemental Materials
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Not lost in translation: stepwise regulation of microRNA targets.Janas, MM, and Novina CD The EMBO journal, 2012/04/20, (2012) Read More / View Supplemental Materials
Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency.Wei, G., Margolin AA, Haery L., Brown E., Cucolo L., Julian B., Shehata S., Kung AL, Beroukhim R., and Golub T. R. Cancer cell, 2012/04/17, Volume 21, Issue 4, p.547-62, (2012) Read More / View Supplemental Materials
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INRICH: Interval-based Enrichment Analysis for Genome Wide Association Studies.Lee, PH, O'Dushlaine C., Thomas B., and Purcell SM Bioinformatics (Oxford, England), 2012/04/17, (2012) Read More / View Supplemental Materials
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RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities.Barczak, AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L., Borowsky ML, Onderdonk AB, Stanley SA, Kaur D., Bryant KF, Knipe DM, Sloutsky A., and Hung DT Proceedings of the National Academy of Sciences of the United States of America, 2012/04/17, Volume 109, Issue 16, p.6217-22, (2012) Read More / View Supplemental Materials
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Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair.Reynolds, JJ, Walker AK, Gilmore EC, Walsh CA, and Caldecott KW Nucleic acids research, 2012/04/15, (2012) Read More / View Supplemental Materials
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pIRS: Profile based Illumina pair-end Reads Simulator.Hu, X., Yuan J., Shi Y., Lu J., Liu B., Li Z., Chen Y., Mu D., Zhang H., Li N., Yue Z., Bai F., Li H., and An WF Bioinformatics (Oxford, England), 2012/04/15, (2012) Read More / View Supplemental Materials
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Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.Udeshi, ND, Mani D. R., Eisenhaure T., Mertins P., Jaffe JD, Clauser KR, Hacohen N., and Carr SA Molecular & cellular proteomics : MCP, 2012/04/14, (2012) Read More / View Supplemental Materials
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Harnessing genomics and genome biology to understand malaria biology.Volkman, SK, Neafsey DE, Schaffner SF, Park DJ, and Wirth DF Nature reviews. Genetics, 2012/04/12, Volume 13, Issue 5, p.315-28, (2012) Read More / View Supplemental Materials
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Parametric modeling of cellular state transitions as measured with flow cytometry.Ho, HJ, Lin TI, Chang HH, Haase SB, Huang S., and Pyne S. BMC bioinformatics, 2012/04/12, Volume 13 Suppl 5, p.S5, (2012) Read More / View Supplemental Materials
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Fast and accurate inference of local ancestry in Latino populations.Baran, Y., Pasaniuc B., Sankararaman S., Torgerson DG, Gignoux C., Eng C., Rodriguez-Cintron W., Chapela R., Ford JG, Avila PC, Rodriguez-Santana J., Burchard EG, and Halperin E. Bioinformatics (Oxford, England), 2012/04/11, (2012) Read More / View Supplemental Materials
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Alzheimer Disease Susceptibility Loci: Evidence for a Protein Network under Natural Selection.Raj, T., Shulman JM, Keenan BT, Chibnik LB, Evans DA, Bennett DA, Stranger BE, and De Jager PL American journal of human genetics, 2012/04/06, Volume 90, Issue 4, p.720-6, (2012) Read More / View Supplemental Materials
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The genomic basis of adaptive evolution in threespine sticklebacks.Jones, FC, Grabherr MG, Chan YF, Russell P., Mauceli E., Johnson J., Swofford R., Pirun M., Zody MC, White S., Birney E., Searle S., Schmutz J., Grimwood J., Dickson MC, Myers RM, Miller CT, Summers BR, Knecht AK, Brady SD, et al. Nature, 2012/04/04, Volume 484, Issue 7392, p.55-61, (2012) Read More / View Supplemental Materials
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Patterns and rates of exonic de novo mutations in autism spectrum disorders.Neale, BM, Kou Y., Liu L., Ma'ayan A., Samocha KE, Sabo A., Lin CF, Stevens C., Wang LS, Makarov V., Polak P., Yoon S., Maguire J., Crawford EL, Campbell NG, Geller ET, Valladares O., Schafer C., Liu H., Zhao T., et al. Nature, 2012/04/04, (2012) Read More / View Supplemental Materials
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Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.Kubicek, S., Gilbert JC, Fomina-Yadlin D., Gitlin AD, Yuan Y., Wagner FF, Holson EB, Luo T., Lewis TA, Taylor B., Gupta S., Shamji AF, Wagner BK, Clemons PA, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/04/03, Volume 109, Issue 14, p.5364-9, (2012) Read More / View Supplemental Materials
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.Barretina, J., Caponigro G., Stransky N., Venkatesan K., Margolin AA, Kim S., Wilson CJ, Lehár J., Kryukov GV, Sonkin D., Reddy A., Liu M., Murray L., Berger MF, Monahan JE, Morais P., Meltzer J., Korejwa A., Jané-Valbuena J., Mapa FA, et al. Nature, 2012/03/28, Volume 483, Issue 7391, p.603-7, (2012) Read More / View Supplemental Materials
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A unique regulatory phase of DNA methylation in the early mammalian embryo.Smith, ZD, Chan MM, Mikkelsen TS, Gu H., Gnirke A., Regev A., and Meissner A. Nature, 2012/03/28, Volume 484, Issue 7394, p.339-44, (2012) Read More / View Supplemental Materials
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Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.Stahl, EA, Wegmann D., Trynka G., Gutierrez-Achury J., Do R., Voight BF, Kraft P., Chen R., Kallberg HJ, Kurreeman FA, Diabetes Genetics Replication and Meta-analysis Consortium, Myocardial Infarction Genetics Consortium, Kathiresan S., Wijmenga C., Gregersen PK, Alfredsson L., Siminovitch KA, Worthington J., de Bakker PI, Raychaudhuri S., et al. Nature genetics, 2012/03/25, (2012) Read More / View Supplemental Materials
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Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program.Mather, KJ, Christophi CA, Jablonski KA, Knowler WC, Goldberg RB, Kahn SE, Spector T., Dastani Z., Waterworth D., Richards JB, Funahashi T., Pi-Sunyer FX, Pollin TI, Florez JC, Franks PW, and for the Diabetes Prevention Program Research Group Diabetic medicine : a journal of the British Diabetic Association, 2012/03/24, (2012) Read More / View Supplemental Materials
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Quantitative assessment of ChIP-grade antibodies directed against histone modifications reveals patterns of co-occurring marks on histone protein molecules.Peach, SE, Rudomin EL, Udeshi ND, Carr SA, and Jaffe JD Molecular & cellular proteomics : MCP, 2012/03/23, (2012) Read More / View Supplemental Materials
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Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.Harwell, CC, Parker PR, Gee SM, Okada A., McConnell SK, Kreitzer AC, and Kriegstein AR Neuron, 2012/03/22, Volume 73, Issue 6, p.1116-26, (2012) Read More / View Supplemental Materials
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A tell-tail sign of chromatin: histone mutations drive pediatric glioblastoma.Rheinbay, E., Louis DN, Bernstein BE, and Suvà ML Cancer cell, 2012/03/20, Volume 21, Issue 3, p.329-31, (2012) Read More / View Supplemental Materials
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Evidence that nuclear factor IA inhibits repair after white matter injury.Fancy, SP, Glasgow SM, Finley M., Rowitch DH, and Deneen B. Annals of neurology, 2012/03/19, (2012) Read More / View Supplemental Materials
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Rapid, field-deployable method for genotyping and discovery of drug-resistance single nucleotide polymorphisms in Plasmodium falciparum.Daniels, R., Ndiaye D., Wall M., McKinney J., Séne PD, Sabeti PC, Volkman SK, Mboup S., and Wirth DF Antimicrobial agents and chemotherapy, 2012/03/19, (2012) Read More / View Supplemental Materials
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Genetics of human cardiovascular disease.Kathiresan, S., and Srivastava D. Cell, 2012/03/16, Volume 148, Issue 6, p.1242-57, (2012) Read More / View Supplemental Materials
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Reprogramming Cellular Identity for Regenerative Medicine.Cherry, AB, and Daley GQ Cell, 2012/03/16, Volume 148, Issue 6, p.1110-1122, (2012) Read More / View Supplemental Materials
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2011 Curt Stern Award Address.Altshuler, D. American journal of human genetics, 2012/03/09, Volume 90, Issue 3, p.407-409, (2012) Read More / View Supplemental Materials
Common SNP-Based Haplotype Analysis of the 4p16.3 Huntington Disease Gene Region.Lee, JM, Gillis T., Mysore JS, Ramos EM, Myers RH, Hayden MR, Morrison PJ, Nance M., Ross CA, Margolis RL, Squitieri F., Griguoli A., Di Donato S., Gomez-Tortosa E., Ayuso C., Suchowersky O., Trent RJ, McCusker E., Novelletto A., Frontali M., et al. American journal of human genetics, 2012/03/09, Volume 90, Issue 3, p.434-444, (2012) Read More / View Supplemental Materials
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Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci.Saxena, R., Elbers CC, Guo Y., Peter I., Gaunt TR, Mega JL, Lanktree MB, Tare A., Castillo BA, Li YR, Johnson T., Bruinenberg M., Gilbert-Diamond D., Rajagopalan R., Voight BF, Balasubramanyam A., Barnard J., Bauer F., Baumert J., Bhangale T., et al. American journal of human genetics, 2012/03/09, Volume 90, Issue 3, p.410-425, (2012) Read More / View Supplemental Materials
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Use of a Multiethnic Approach to Identify Rheumatoid- Arthritis-Susceptibility Loci, 1p36 and 17q12.Kurreeman, FA, Stahl EA, Okada Y., Liao K., Diogo D., Raychaudhuri S., Freudenberg J., Kochi Y., Patsopoulos NA, Gupta N., investigators CLEAR, Sandor C., Bang SY, Lee HS, Padyukov L., Suzuki A., Siminovitch K., Worthington J., Gregersen PK, Hughes LB, et al. American journal of human genetics, 2012/03/09, Volume 90, Issue 3, p.524-532, (2012) Read More / View Supplemental Materials
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Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor.Dockendorff, C., Aisiku O., VerPlank L., Dilks JR, Smith DA, Gunnink SF, Dowal L., Negri J., Palmer M., Macpherson L., Schreiber SL, and Flaumenhaft R. ACS medicinal chemistry letters, 2012/03/08, Volume 3, Issue 3, p.232-237, (2012) Read More / View Supplemental Materials
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Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.Lohr, JG, Stojanov P., Lawrence MS, Auclair D., Chapuy B., Sougnez C., Cruz-Gordillo P., Knoechel B., Asmann YW, Slager SL, Novak AJ, Dogan A., Ansell SM, Link BK, Zou L., Gould J., Saksena G., Stransky N., Rangel-Escareño C., Fernandez-Lopez JC, et al. Proceedings of the National Academy of Sciences of the United States of America, 2012/03/06, Volume 109, Issue 10, p.3879-84, (2012) Read More / View Supplemental Materials
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Chromatin-modifying enzymes as modulators of reprogramming.Onder, TT, Kara N., Cherry A., Sinha AU, Zhu N., Bernt KM, Cahan P., Marcarci BO, Unternaehrer J., Gupta PB, Lander E. S., Armstrong SA, and Daley GQ Nature, 2012/03/04, Volume 483, Issue 7391, p.598-602, (2012) Read More / View Supplemental Materials
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Circumventing cancer drug resistance in the era of personalized medicine.Garraway, LA, and Jänne PA Cancer discovery, 2012/03/01, Volume 2, Issue 3, p.214-26, (2012) Read More / View Supplemental Materials
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Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks.Trapnell, C., Roberts A., Goff L., Pertea G., Kim D., Kelley DR, Pimentel H., Salzberg SL, Rinn JL, and Pachter L. Nature protocols, 2012/03/01, Volume 7, Issue 3, p.562-78, (2012) Read More / View Supplemental Materials
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Genome-wide association studies of schizophrenia: does bigger lead to better results?Bergen, SE, and Petryshen TL Current opinion in psychiatry, 2012/03/01, Volume 25, Issue 2, p.76-82, (2012) Read More / View Supplemental Materials
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High-Throughput RT-PCR for small-molecule screening assays.Bittker, JA Current protocols in chemical biology, 2012/03/01, Volume 4, Issue 1, p.49-63, (2012) Read More / View Supplemental Materials
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Highly sensitive and specific detection of rare variants in mixed viral populations from massively parallel sequence data.Macalalad, AR, Zody MC, Charlebois P., Lennon NJ, Newman RM, Malboeuf CM, Ryan EM, Boutwell CL, Power KA, Brackney DE, Pesko KN, Levin JZ, Ebel GD, Allen TM, Birren BW, and Henn MR PLoS computational biology, 2012/03/01, Volume 8, Issue 3, p.e1002417, (2012) Read More / View Supplemental Materials
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MYC Is Activated by USP2a-Mediated Modulation of MicroRNAs in Prostate Cancer.Benassi, B., Flavin R., Marchionni L., Zanata S., Pan Y., Chowdhury D., Marani M., Strano S., Muti P., Blandino G., and Loda M. Cancer discovery, 2012/03/01, Volume 2, Issue 3, p.236-247, (2012) Read More / View Supplemental Materials
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Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection.Henn, MR, Boutwell CL, Charlebois P., Lennon NJ, Power KA, Macalalad AR, Berlin AM, Malboeuf CM, Ryan EM, Gnerre S., Zody MC, Erlich RL, Green LM, Berical A., Wang Y., Casali M., Streeck H., Bloom AK, Dudek T., Tully D., et al. PLoS pathogens, 2012/03/01, Volume 8, Issue 3, p.e1002529, (2012) Read More / View Supplemental Materials
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An epigenetic blockade of cognitive functions in the neurodegenerating brain.Gräff, J., Rei D., Guan JS, Wang WY, Seo J., Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M., Su SC, Samiei A., Joseph N., Haggarty SJ, Delalle I., and Tsai LH Nature, 2012/02/29, (2012) Read More / View Supplemental Materials
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ChromHMM: automating chromatin-state discovery and characterization.Ernst, J., and Kellis M. Nature methods, 2012/02/28, Volume 9, Issue 3, p.215-6, (2012) Read More / View Supplemental Materials
Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay.Melnikov, A., Murugan A., Zhang X., Tesileanu T., Wang L., Rogov P., Feizi S., Gnirke A., Callan CG Jr, Kinney JB, Kellis M., Lander E. S., and Mikkelsen TS Nature biotechnology, 2012/02/26, Volume 30, Issue 3, p.271-7, (2012) Read More / View Supplemental Materials
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Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011.Grad, YH, Lipsitch M., Feldgarden M., Arachchi HM, Cerqueira GC, FitzGerald M., Godfrey P., Haas BJ, Murphy CI, Russ C., Sykes S., Walker BJ, Wortman JR, Young S., Zeng Q., Abouelleil A., Bochicchio J., Chauvin S., Desmet T., Gujja S., et al. Proceedings of the National Academy of Sciences of the United States of America, 2012/02/21, Volume 109, Issue 8, p.3065-70, (2012) Read More / View Supplemental Materials
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STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability.Luo, T., Masson K., Jaffe JD, Silkworth W., Ross NT, Scherer CA, Scholl C., Fröhling S., Carr SA, Stern AM, Schreiber SL, and Golub T. R. Proceedings of the National Academy of Sciences of the United States of America, 2012/02/21, Volume 109, Issue 8, p.2860-5, (2012) Read More / View Supplemental Materials
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Cost-effective, high-throughput DNA sequencing libraries for multiplexed target capture.Rohland, N., and Reich D. Genome research, 2012/02/16, (2012) Read More / View Supplemental Materials
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A PIP Gets the Plasmodium Protein Export Pathway Going.Jiang, RH, and Marti M. Cell host & microbe, 2012/02/16, Volume 11, Issue 2, p.99-100, (2012) Read More / View Supplemental Materials
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Unified modeling of gene duplication, loss, and coalescence using a locus tree.Rasmussen, MD, and Kellis M. Genome research, 2012/02/16, (2012) Read More / View Supplemental Materials
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Development of small-molecule probes that selectively kill cells induced to express mutant RAS.Weïwer, M., Bittker JA, Lewis TA, Shimada K., Yang WS, Macpherson L., Dandapani S., Palmer M., Stockwell BR, Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2012/02/15, Volume 22, Issue 4, p.1822-6, (2012) Read More / View Supplemental Materials
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Modular regulatory principles of large non-coding RNAs.Guttman, M., and Rinn JL Nature, 2012/02/15, Volume 482, Issue 7385, p.339-46, (2012) Read More / View Supplemental Materials
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Genome-wide siRNA screen for mediators of NF-κB activation.Gewurz, BE, Towfic F., Mar JC, Shinners NP, Takasaki K., Zhao B., Cahir-McFarland ED, Quackenbush J., Xavier RJ, and Kieff E. Proceedings of the National Academy of Sciences of the United States of America, 2012/02/14, Volume 109, Issue 7, p.2467-72, (2012) Read More / View Supplemental Materials
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Build/Couple/Pair Strategy for the Synthesis of Stereochemically Diverse Macrolactams via Head-to-Tail Cyclization.Fitzgerald, ME, Mulrooney CA, Duvall JR, Wei J., Suh BC, Akella LB, Vrcic A., and Marcaurelle LA ACS combinatorial science, 2012/02/13, Volume 14, Issue 2, p.89-96, (2012) Read More / View Supplemental Materials
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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.Heidebrecht RW, Jr, Mulrooney C., Austin CP, Barker RH Jr, Beaudoin JA, Cheng KC, Comer E., Dandapani S., Dick J., Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M., Guha R., Hinkson P., Kramer M., Lukens AK, Masi D., Marcaurelle LA, et al. ACS medicinal chemistry letters, 2012/02/09, Volume 3, Issue 2, p.112-117, (2012) Read More / View Supplemental Materials
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Treatment of the respiratory distress syndrome in newborns: smoothened agonist counterbalances deleterious effects of glucocorticoids .Griveau, A. Medecine sciences : M/S, 2012/02/01, Volume 28, Issue 2, p.141-3, (2012) Read More / View Supplemental Materials
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.Raychaudhuri, S., Sandor C., Stahl EA, Freudenberg J., Lee HS, Jia X., Alfredsson L., Padyukov L., Klareskog L., Worthington J., Siminovitch KA, Bae SC, Plenge RM, Gregersen PK, and de Bakker PI Nature genetics, 2012/01/29, Volume 44, Issue 3, p.291-6, (2012) Read More / View Supplemental Materials
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RNA folding with soft constraints: reconciliation of probing data and thermodynamic secondary structure prediction.Washietl, S., Hofacker IL, Stadler PF, and Kellis M. Nucleic acids research, 2012/01/28, (2012) Read More / View Supplemental Materials
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The numerology of T cell functional diversity.Haining, WN Immunity, 2012/01/27, Volume 36, Issue 1, p.10-2, (2012) Read More / View Supplemental Materials
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The mystery of missing heritability: Genetic interactions create phantom heritability.Zuk, O., Hechter E., Sunyaev SR, and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2012/01/24, Volume 109, Issue 4, p.1193-8, (2012) Read More / View Supplemental Materials
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Human evolutionary genomics: ethical and interpretive issues.Vitti, JJ, Cho MK, Tishkoff SA, and Sabeti PC Trends in genetics : TIG, 2012/01/20, (2012) Read More / View Supplemental Materials
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Genetic variation at CR1 increases risk of cerebral amyloid angiopathy.Biffi, A., Shulman JM, Jagiella JM, Cortellini L., Ayres AM, Schwab K., Brown DL, Silliman SL, Selim M., Worrall BB, Meschia JF, Slowik A., De Jager PL, Greenberg SM, Schneider JA, Bennett DA, and Rosand J. Neurology, 2012/01/18, (2012) Read More / View Supplemental Materials
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Analyzing and minimizing PCR amplification bias in Illumina sequencing libraries.Aird, D., Ross MG, Chen WS, Danielsson M., Fennell T., Russ C., Jaffe DB, Nusbaum C., and Gnirke A. Genome biology, 2012/01/09, Volume 12, Issue 2, p.R18, (2012) Read More / View Supplemental Materials
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Assisted assembly: how to improve a de novo genome assembly by using related species.Gnerre, S., Lander E. S., Lindblad-Toh K., and Jaffe DB Genome biology, 2012/01/09, Volume 10, Issue 8, p.R88, (2012) Read More / View Supplemental Materials
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Chemical Genetic Analysis of Platelet Granule Secretion-Probe 1VerPlank, L., Dockendorff C., Negri J., Perez JR, Dilks J., Macpherson L., Palmer M., Flaumenhaft R., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
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Chemical Genetic Analysis of Platelet Granule Secretion-Probe 2VerPlank, L., Dockendorff C., Negri J., Perez JR, Dilks J., Macpherson L., Palmer M., Flaumenhaft R., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
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Chemical Genetic Analysis of Platelet Granule Secretion-Probe 3VerPlank, L., Dockendorff C., Negri J., Perez JR, Dilks J., Macpherson L., Palmer M., Flaumenhaft R., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
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Exploiting nucleotide composition to engineer promoters.Grabherr, MG, Pontiller J., Mauceli E., Ernst W., Baumann M., Biagi T., Swofford R., Russell P., Zody MC, Di Palma F., Lindblad-Toh K., and Grabherr RM PloS one, 2012/01/09, Volume 6, Issue 5, p.e20136, (2012) Read More / View Supplemental Materials
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Extracting rich information from images.Carpenter, AE Methods in molecular biology (Clifton, N.J.), 2012/01/09, Volume 486, p.193-211, (2012) Read More / View Supplemental Materials
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The fungal genome initiative and lessons learned from genome sequencing.Cuomo, CA, and Birren BW Methods in enzymology, 2012/01/09, Volume 470, p.833-55, (2012) Read More / View Supplemental Materials
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GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers.Mermel, CH, Schumacher SE, Hill B., Meyerson ML, Beroukhim R., and Getz G. Genome biology, 2012/01/09, Volume 12, Issue 4, p.R41, (2012) Read More / View Supplemental Materials
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High-throughput real-time PCR for detection of gene-expression levels.Wagner, BK, and Arany Z. Methods in molecular biology (Clifton, N.J.), 2012/01/09, Volume 486, p.167-75, (2012) Read More / View Supplemental Materials
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Identification of a small molecule that selectively activates alpha-synuclein translational expressionRoss, NT, Metkar SR, Le H., Burbank J., Cahill C., Germain A., Macpherson L., Bittker J., Palmer M., Rogers J., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
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Identification of a small molecule that selectively inhibits alpha-synuclein translational expressionRoss, NT, Metkar SR, Le H., Burbank J., Cahill C., Germain A., Macpherson L., Bittker J., Palmer M., Rogers J., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
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Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet CellsFaloon, PW, Chou DHC, Forbeck EM, Walpita D., Morgan B., Buhrlage S., Ting A., Perez J., MacPherson LJ, Duvall JR, Dandapani S., Marcaurelle LA, Munoz B., Palmer M., Foley M., Wagner B., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
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Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 1An, WF, Metkar SR, Nag PP, Hartland CL, Barker D., Perez JR, Sun H., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
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Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 2An, WF, Metkar SR, Lewis TA, Nag PP, Hartland CL, Barker D., Perez JR, Sun H., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
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Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 3An, WF, Metkar SR, Youngsaye W., Nag PP, Hartland CL, Barker D., Perez JR, Sun H., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
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Identification of Small-Molecule Inhibitors of Trypansoma cruzi InfectionCarmody, LC, Germain A., Barker D., Galan-Rodriguez C., Bettiol E., Rodriguez A., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
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Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 1Carmody, LC, Germain A., Barker D., Galan-Rodriguez C., Bettiol E., Rodriguez A., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
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Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 3Carmody, LC, Germain A., Barker D., Galan-Rodriguez C., Bettiol E., Rodriguez A., Macpherson L., Palmer M., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
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Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC.Ong, SE, Li X., Schenone M., Schreiber SL, and Carr SA Methods in molecular biology (Clifton, N.J.), 2012/01/09, Volume 803, p.129-40, (2012) Read More / View Supplemental Materials
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