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2010
Reconstructing gene histories in Ascomycota fungi.Wapinski, I., and Regev A. Methods in enzymology, 2010/01/01, Volume 470, p.447-85, (2010) Read More / View Supplemental Materials
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Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2Bittker, JA, Weiwer M., Lewis T., Shimada K., Yang WS, Macpherson L., Dandapani S., Munoz B., Palmer M., Stockwell BR, and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
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Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines.Martyn, DC, Nijjar A., Celatka CA, Mazitschek R., Cortese JF, Tyndall E., Liu H., Fitzgerald MM, O'Shea TJ, Danthi S., and Clardy J. Bioorganic & medicinal chemistry letters, 2010/01/01, Volume 20, Issue 1, p.228-31, (2010) Read More / View Supplemental Materials
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Understanding gene sequence variation in the context of transcription regulation in yeast.Gat-Viks, I., Meller R., Kupiec M., and Shamir R. PLoS genetics, 2010/01/01, Volume 6, Issue 1, p.e1000800, (2010) Read More / View Supplemental Materials
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2009
Direct control of mitochondrial function by mTOR.Ramanathan, A., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2009/12/29, Volume 106, Issue 52, p.22229-32, (2009) Read More / View Supplemental Materials
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A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection.Shapira, SD, Gat-Viks I., Shum BO, Dricot A., Degrace MM, Wu L., Gupta PB, Hao T., Silver SJ, Root DE, Hill DE, Regev A., and Hacohen N. Cell, 2009/12/24, Volume 139, Issue 7, p.1255-67, (2009) Read More / View Supplemental Materials
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Fungal regulatory evolution: cis and trans in the balance.Thompson, DA, and Regev A. FEBS letters, 2009/12/17, Volume 583, Issue 24, p.3959-65, (2009) Read More / View Supplemental Materials
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Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells.Stanley, SA, and Hung DT Science translational medicine, 2009/12/16, Volume 1, Issue 11, p.11ps13, (2009) Read More / View Supplemental Materials
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Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling.Wagner, BK, and Clemons PA Current opinion in chemical biology, 2009/12/01, Volume 13, Issue 5-6, p.539-48, (2009) Read More / View Supplemental Materials
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Dicer1 functions as a haploinsufficient tumor suppressor.Kumar, MS, Pester RE, Chen CY, Lane K., Chin C., Lu J., Kirsch DG, Golub T. R., and Jacks T. Genes & development, 2009/12/01, Volume 23, Issue 23, p.2700-4, (2009) Read More / View Supplemental Materials
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Introduction to the quantitative analysis of two-dimensional fluorescence microscopy images for cell-based screening.Ljosa, V., and Carpenter AE PLoS computational biology, 2009/12/01, Volume 5, Issue 12, p.e1000603, (2009) Read More / View Supplemental Materials
Retinal vasculopathy in a family with autosomal dominant dyskeratosis congenita.Johnson, CA, Hatfield M., and Pulido JS Ophthalmic genetics, 2009/12/01, Volume 30, Issue 4, p.181-4, (2009) Read More / View Supplemental Materials
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ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.Markljung, E., Jiang L., Jaffe JD, Mikkelsen TS, Wallerman O., Larhammar M., Zhang X., Wang L., Saenz-Vash V., Gnirke A., Lindroth AM, Barrés R., Yan J., Strömberg S., De S., Pontén F., Lander E. S., Carr SA, Zierath JR, Kullander K., et al. PLoS biology, 2009/12/01, Volume 7, Issue 12, p.e1000256, (2009) Read More / View Supplemental Materials
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Copper-mediated amidation of heterocyclic and aromatic C-H bonds.Wang, Q., and Schreiber SL Organic letters, 2009/11/19, Volume 11, Issue 22, p.5178-80, (2009) Read More / View Supplemental Materials
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Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.Peng, LF, Stanton BZ, Maloof N., Wang X., and Schreiber SL Bioorganic & medicinal chemistry letters, 2009/11/15, Volume 19, Issue 22, p.6319-25, (2009) Read More / View Supplemental Materials
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Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells.Pizzirani, D., Roberti M., Grimaudo S., Di Cristina A., Pipitone RM, Tolomeo M., and Recanatini M. Journal of medicinal chemistry, 2009/11/12, Volume 52, Issue 21, p.6936-40, (2009) Read More / View Supplemental Materials
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Genome sequence, comparative analysis, and population genetics of the domestic horse.Wade, CM, Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear TL, Adelson DL, Bailey E., Bellone RR, Blöcker H., Distl O., Edgar RC, Garber M., Leeb T., Mauceli E., MacLeod JN, Penedo MC, Raison JM, Sharpe T., et al. Science (New York, N.Y.), 2009/11/06, Volume 326, Issue 5954, p.865-7, (2009) Read More / View Supplemental Materials
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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.Barbie, DA, Tamayo P., Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P., Meylan E., Scholl C., Fröhling S., Chan EM, Sos ML, Michel K., Mermel C., Silver SJ, Weir BA, Reiling JH, Sheng Q., Gupta PB, et al. Nature, 2009/11/05, Volume 462, Issue 7269, p.108-12, (2009) Read More / View Supplemental Materials
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Nodal morphogens.Schier, AF Cold Spring Harbor perspectives in biology, 2009/11/01, Volume 1, Issue 5, p.a003459, (2009) Read More / View Supplemental Materials
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Empirical Bayes analysis of quantitative proteomics experiments.Margolin, AA, Ong SE, Schenone M., Gould R., Schreiber SL, Carr SA, and Golub T. R. PloS one, 2009/10/14, Volume 4, Issue 10, p.e7454, (2009) Read More / View Supplemental Materials
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Comprehensive mapping of long-range interactions reveals folding principles of the human genome.Lieberman-Aiden, E., van Berkum NL, Williams L., Imakaev M., Ragoczy T., Telling A., Amit I., Lajoie BR, Sabo PJ, Dorschner MO, Sandstrom R., Bernstein B., Bender MA, Groudine M., Gnirke A., Stamatoyannopoulos J., Mirny LA, Lander E. S., and Dekker J. Science (New York, N.Y.), 2009/10/09, Volume 326, Issue 5950, p.289-93, (2009) Read More / View Supplemental Materials
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Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses.Amit, I., Garber M., Chevrier N., Leite AP, Donner Y., Eisenhaure T., Guttman M., Grenier JK, Li W., Zuk O., Schubert LA, Birditt B., Shay T., Goren A., Zhang X., Smith Z., Deering R., McDonald RC, Cabili M., Bernstein BE, et al. Science (New York, N.Y.), 2009/10/09, Volume 326, Issue 5950, p.257-63, (2009) Read More / View Supplemental Materials
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Proteomic and genetic approaches identify Syk as an AML target.Hahn, CK, Berchuck JE, Ross KN, Kakoza RM, Clauser K., Schinzel AC, Ross L., Galinsky I., Davis TN, Silver SJ, Root DE, Stone RM, DeAngelo DJ, Carroll M., Hahn WC, Carr SA, Golub T. R., Kung AL, and Stegmaier K. Cancer cell, 2009/10/06, Volume 16, Issue 4, p.281-94, (2009) Read More / View Supplemental Materials
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Alpha shapes applied to molecular shape characterization exhibit novel properties compared to established shape descriptors.Wilson, JA, Bender A., Kaya T., and Clemons PA Journal of chemical information and modeling, 2009/10/01, Volume 49, Issue 10, p.2231-41, (2009) Read More / View Supplemental Materials
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Identification and characterization of novel sirtuin inhibitor scaffolds.Sanders, BD, Jackson B., Brent M., Taylor AM, Dang W., Berger SL, Schreiber SL, Howitz K., and Marmorstein R. Bioorganic & medicinal chemistry, 2009/10/01, Volume 17, Issue 19, p.7031-41, (2009) Read More / View Supplemental Materials
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Quantification of cardiovascular biomarkers in patient plasma by targeted mass spectrometry and stable isotope dilution.Keshishian, H., Addona T., Burgess M., Mani D. R., Shi X., Kuhn E., Sabatine MS, Gerszten RE, and Carr SA Molecular & cellular proteomics : MCP, 2009/10/01, Volume 8, Issue 10, p.2339-49, (2009) Read More / View Supplemental Materials
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Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum.Martyn, DC, Beletsky G., Cortese JF, Tyndall E., Liu H., Fitzgerald MM, O'Shea TJ, Liang B., and Clardy J. Bioorganic & medicinal chemistry letters, 2009/10/01, Volume 19, Issue 19, p.5657-60, (2009) Read More / View Supplemental Materials
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Chemical tools for dissecting bacterial physiology and virulence.Stanley, SA, and Hung DT Biochemistry, 2009/09/22, Volume 48, Issue 37, p.8776-86, (2009) Read More / View Supplemental Materials
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Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans.Haas, BJ, Kamoun S., Zody MC, Jiang RH, Handsaker RE, Cano LM, Grabherr M., Kodira CD, Raffaele S., Torto-Alalibo T., Bozkurt TO, Ah-Fong AM, Alvarado L., Anderson VL, Armstrong MR, Avrova A., Baxter L., Beynon J., Boevink PC, Bollmann SR, et al. Nature, 2009/09/17, Volume 461, Issue 7262, p.393-8, (2009) Read More / View Supplemental Materials
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Phase Coupled Meta-analysis: sensitive detection of oscillations in cell cycle gene expression, as applied to fission yeast.Pyne, S., Gutman R., Kim CS, and Futcher B. BMC genomics, 2009/09/17, Volume 10, p.440, (2009) Read More / View Supplemental Materials
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Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.Hoshida, Y., Nijman SM, Kobayashi M., Chan JA, Brunet JP, Chiang DY, Villanueva A., Newell P., Ikeda K., Hashimoto M., Watanabe G., Gabriel S., Friedman SL, Kumada H., Llovet JM, and Golub T. R. Cancer research, 2009/09/15, Volume 69, Issue 18, p.7385-92, (2009) Read More / View Supplemental Materials
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MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer.Olson, P., Lu J., Zhang H., Shai A., Chun MG, Wang Y., Libutti SK, Nakakura EK, Golub T. R., and Hanahan D. Genes & development, 2009/09/15, Volume 23, Issue 18, p.2152-65, (2009) Read More / View Supplemental Materials
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Using expression and genotype to predict drug response in yeast.Ruderfer, DM, Roberts DC, Schreiber SL, Perlstein EO, and Kruglyak L. PloS one, 2009/09/04, Volume 4, Issue 9, p.e6907, (2009) Read More / View Supplemental Materials
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Cancer stem cells: mirage or reality?Gupta, PB, Chaffer CL, and Weinberg R. A. Nature medicine, 2009/09/01, Volume 15, Issue 9, p.1010-2, (2009) Read More / View Supplemental Materials
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Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia.Huang, P., and Schier AF Development (Cambridge, England), 2009/09/01, Volume 136, Issue 18, p.3089-98, (2009) Read More / View Supplemental Materials
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Identification of selective inhibitors of cancer stem cells by high-throughput screening.Gupta, PB, Onder TT, Jiang G., Tao K., Kuperwasser C., Weinberg R. A., and Lander E. S. Cell, 2009/08/21, Volume 138, Issue 4, p.645-59, (2009) Read More / View Supplemental Materials
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Formation of the RFX gene regulatory complex induces folding of the interaction domain of RFXAP.Briggs, L., Laird K., Boss JM, and Garvie CW Proteins, 2009/08/15, Volume 76, Issue 3, p.655-64, (2009) Read More / View Supplemental Materials
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The Sequence Alignment/Map format and SAMtools.Li, H., Handsaker B., Wysoker A., Fennell T., Ruan J., Homer N., Marth G., Abecasis G., Durbin R., and 1000 Genome Project Data Processing Subgroup Bioinformatics (Oxford, England), 2009/08/15, Volume 25, Issue 16, p.2078-9, (2009) Read More / View Supplemental Materials
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Interpreting expression data with metabolic flux models: predicting Mycobacterium tuberculosis mycolic acid production.Colijn, C., Brandes A., Zucker J., Lun DS, Weiner B., Farhat MR, Cheng TY, Moody DB, Murray M., and Galagan JE PLoS computational biology, 2009/08/01, Volume 5, Issue 8, p.e1000489, (2009) Read More / View Supplemental Materials
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Taking aim at aggressive cancer cells.Lander, E., Jiang G., and Tao K. Cancer biology & therapy, 2009/08/01, Volume 8, Issue 16, p.ii, (2009) Read More / View Supplemental Materials
Transcriptional regulatory circuits: predicting numbers from alphabets.Kim, HD, Shay T., O'Shea EK, and Regev A. Science (New York, N.Y.), 2009/07/24, Volume 325, Issue 5939, p.429-32, (2009) Read More / View Supplemental Materials
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Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression.Khalil, AM, Guttman M., Huarte M., Garber M., Raj A., Rivea Morales D., Thomas K., Presser A., Bernstein BE, van Oudenaarden A., Regev A., Lander E. S., and Rinn JL Proceedings of the National Academy of Sciences of the United States of America, 2009/07/14, Volume 106, Issue 28, p.11667-72, (2009) Read More / View Supplemental Materials
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SnapShot: Ca2+-calcineurin-NFAT signaling.Crabtree, GR, and Schreiber SL Cell, 2009/07/10, Volume 138, Issue 1, p.210, 210.e1, (2009) Read More / View Supplemental Materials
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.Vasudevan, KM, Barbie DA, Davies MA, Rabinovsky R., McNear CJ, Kim JJ, Hennessy BT, Tseng H., Pochanard P., Kim SY, Dunn IF, Schinzel AC, Sandy P., Hoersch S., Sheng Q., Gupta PB, Boehm JS, Reiling JH, Silver S., Lu Y., et al. Cancer cell, 2009/07/07, Volume 16, Issue 1, p.21-32, (2009) Read More / View Supplemental Materials
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microRNA expression during trophectoderm specification.Viswanathan, SR, Mermel CH, Lu J., Lu CW, Golub T. R., and Daley GQ PloS one, 2009/07/03, Volume 4, Issue 7, p.e6143, (2009) Read More / View Supplemental Materials
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Aziridines as intermediates in diversity-oriented syntheses of alkaloids.Taylor, AM, and Schreiber SL Tetrahedron letters, 2009/07/02, Volume 50, Issue 26, p.3230-3233, (2009) Read More / View Supplemental Materials
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Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication.Ma, LJ, Ibrahim AS, Skory C., Grabherr MG, Burger G., Butler M., Elias M., Idnurm A., Lang BF, Sone T., Abe A., Calvo SE, Corrochano LM, Engels R., Fu J., Hansberg W., Kim JM, Kodira CD, Koehrsen MJ, Liu B., et al. PLoS genetics, 2009/07/01, Volume 5, Issue 7, p.e1000549, (2009) Read More / View Supplemental Materials
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Lin28 promotes transformation and is associated with advanced human malignancies.Viswanathan, SR, Powers JT, Einhorn W., Hoshida Y., Ng TL, Toffanin S., O'Sullivan M., Lu J., Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R., Azam M., Teixeira J., Meyerson M., Hughes TP, Llovet JM, Radich J., et al. Nature genetics, 2009/07/01, Volume 41, Issue 7, p.843-8, (2009) Read More / View Supplemental Materials
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Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma.Addona, TA, Abbatiello SE, Schilling B., Skates SJ, Mani D. R., Bunk DM, Spiegelman CH, Zimmerman LJ, Ham AJ, Keshishian H., Hall SC, Allen S., Blackman RK, Borchers CH, Buck C., Cardasis HL, Cusack MP, Dodder NG, Gibson BW, Held JM, et al. Nature biotechnology, 2009/07/01, Volume 27, Issue 7, p.633-41, (2009) Read More / View Supplemental Materials
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Identifying novel constrained elements by exploiting biased substitution patterns.Garber, M., Guttman M., Clamp M., Zody MC, Friedman N., and Xie X. Bioinformatics (Oxford, England), 2009/06/15, Volume 25, Issue 12, p.i54-62, (2009) Read More / View Supplemental Materials
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Identification of AML1-ETO modulators by chemical genomics.Corsello, SM, Roti G., Ross KN, Chow KT, Galinsky I., DeAngelo DJ, Stone RM, Kung AL, Golub T. R., and Stegmaier K. Blood, 2009/06/11, Volume 113, Issue 24, p.6193-205, (2009) Read More / View Supplemental Materials
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Accessing skeletal diversity using catalyst control: formation of n and n + 1 macrocyclic triazole rings.Kelly, AR, Wei J., Kesavan S., Marié JC, Windmon N., Young DW, and Marcaurelle LA Organic letters, 2009/06/04, Volume 11, Issue 11, p.2257-60, (2009) Read More / View Supplemental Materials
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Applications of genomics in melanoma oncogene discovery.Berger, MF, and Garraway LA Hematology/oncology clinics of North America, 2009/06/01, Volume 23, Issue 3, p.397-414, vii, (2009) Read More / View Supplemental Materials
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Developing multiplexed assays for troponin I and interleukin-33 in plasma by peptide immunoaffinity enrichment and targeted mass spectrometry.Kuhn, E., Addona T., Keshishian H., Burgess M., Mani D. R., Lee RT, Sabatine MS, Gerszten RE, and Carr SA Clinical chemistry, 2009/06/01, Volume 55, Issue 6, p.1108-17, (2009) Read More / View Supplemental Materials
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Directed sample interrogation utilizing an accurate mass exclusion-based data-dependent acquisition strategy (AMEx).Rudomin, EL, Carr SA, and Jaffe JD Journal of proteome research, 2009/06/01, Volume 8, Issue 6, p.3154-60, (2009) Read More / View Supplemental Materials
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Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.Raychaudhuri, S., Plenge RM, Rossin EJ, Ng AC, International Schizophrenia Consortium, Purcell SM, Sklar P., Scolnick EM, Xavier RJ, Altshuler D., and Daly M. J. PLoS genetics, 2009/06/01, Volume 5, Issue 6, p.e1000534, (2009) Read More / View Supplemental Materials
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Journal club. A biologist looks at new functions for non-coding RNAs.Huarte, M. Nature, 2009/05/28, Volume 459, Issue 7246, p.487, (2009) Read More / View Supplemental Materials
Automated high-dimensional flow cytometric data analysis.Pyne, S., Hu X., Wang K., Rossin E., Lin TI, Maier LM, Baecher-Allan C., McLachlan GJ, Tamayo P., Hafler DA, De Jager PL, and Mesirov J. P. Proceedings of the National Academy of Sciences of the United States of America, 2009/05/26, Volume 106, Issue 21, p.8519-24, (2009) Read More / View Supplemental Materials
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Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.Burkard, ME, Maciejowski J., Rodriguez-Bravo V., Repka M., Lowery DM, Clauser KR, Zhang C., Shokat KM, Carr SA, Yaffe MB, and Jallepalli PV PLoS biology, 2009/05/05, Volume 7, Issue 5, p.e1000111, (2009) Read More / View Supplemental Materials
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Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.Calvo, SE, Pagliarini DJ, and Mootha VK Proceedings of the National Academy of Sciences of the United States of America, 2009/05/05, Volume 106, Issue 18, p.7507-12, (2009) Read More / View Supplemental Materials
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Amino acid metabolic origin as an evolutionary influence on protein sequence in yeast.de Bivort, BL, Perlstein EO, Kunes S., and Schreiber SL Journal of molecular evolution, 2009/05/01, Volume 68, Issue 5, p.490-7, (2009) Read More / View Supplemental Materials
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Comparative genomic characterization of Francisella tularensis strains belonging to low and high virulence subspecies.Champion, MD, Zeng Q., Nix EB, Nano FE, Keim P., Kodira CD, Borowsky M., Young S., Koehrsen M., Engels R., Pearson M., Howarth C., Larson L., White J., Alvarado L., Forsman M., Bearden SW, Sjöstedt A., Titball R., Michell SL, et al. PLoS pathogens, 2009/05/01, Volume 5, Issue 5, p.e1000459, (2009) Read More / View Supplemental Materials
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Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.Smith, JG, Lowe JK, Kovvali S., Maller JB, Salit J., Daly M. J., Stoffel M., Altshuler DM, Friedman JM, Breslow JL, and Newton-Cheh C. Heart rhythm : the official journal of the Heart Rhythm Society, 2009/05/01, Volume 6, Issue 5, p.634-41, (2009) Read More / View Supplemental Materials
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A human proteome detection and quantitation project.Anderson, NL, Anderson NG, Pearson TW, Borchers CH, Paulovich AG, Patterson SD, Gillette M., Aebersold R., and Carr SA Molecular & cellular proteomics : MCP, 2009/05/01, Volume 8, Issue 5, p.883-6, (2009) Read More / View Supplemental Materials
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Microsatellites are molecular clocks that support accurate inferences about history.Sun, JX, Mullikin JC, Patterson N., and Reich DE Molecular biology and evolution, 2009/05/01, Volume 26, Issue 5, p.1017-27, (2009) Read More / View Supplemental Materials
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Molecular phylogenetic biodiversity assessment of arctic and boreal ectomycorrhizal Lactarius Pers. (Russulales; Basidiomycota) in Alaska, based on soil and sporocarp DNA.Geml, J., Laursen GA, Timling I., McFarland JM, Booth MG, Lennon N., Nusbaum C., and Taylor DL Molecular ecology, 2009/05/01, Volume 18, Issue 10, p.2213-27, (2009) Read More / View Supplemental Materials
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Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.Patel, V., Mazitschek R., Coleman B., Nguyen C., Urgaonkar S., Cortese J., Barker RH, Greenberg E., Tang W., Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, and Clardy J. Journal of medicinal chemistry, 2009/04/23, Volume 52, Issue 8, p.2185-7, (2009) Read More / View Supplemental Materials
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Gold(I)-catalyzed coupling reactions for the synthesis of diverse small molecules using the build/couple/pair strategy.Luo, T., and Schreiber SL Journal of the American Chemical Society, 2009/04/22, Volume 131, Issue 15, p.5667-74, (2009) Read More / View Supplemental Materials
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Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.Nilsson, B., Johansson M., Al-Shahrour F., Carpenter AE, and Ebert BL Bioinformatics (Oxford, England), 2009/04/15, Volume 25, Issue 8, p.1078-9, (2009) Read More / View Supplemental Materials
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Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.Borowiak, M., Maehr R., Chen S., Chen AE, Tang W., Fox JL, Schreiber SL, and Melton DA Cell stem cell, 2009/04/03, Volume 4, Issue 4, p.348-58, (2009) Read More / View Supplemental Materials
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Skeletally diverse small molecules using a build/couple/pair strategy.Uchida, T., Rodriquez M., and Schreiber SL Organic letters, 2009/04/02, Volume 11, Issue 7, p.1559-62, (2009) Read More / View Supplemental Materials
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Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study.Smith, JG, Melander O., Lövkvist H., Hedblad B., Engström G., Nilsson P., Carlson J., Berglund G., Norrving B., and Lindgren A. Circulation. Cardiovascular genetics, 2009/04/01, Volume 2, Issue 2, p.159-64, (2009) Read More / View Supplemental Materials
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Common polymorphic transcript variation in human disease.Fraser, HB, and Xie X. Genome research, 2009/04/01, Volume 19, Issue 4, p.567-75, (2009) Read More / View Supplemental Materials
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MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes.Ikeda, S., He A., Kong SW, Lu J., Bejar R., Bodyak N., Lee KH, Ma Q., Kang PM, Golub T. R., and Pu WT Molecular and cellular biology, 2009/04/01, Volume 29, Issue 8, p.2193-204, (2009) Read More / View Supplemental Materials
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A small molecule that directs differentiation of human ESCs into the pancreatic lineage.Chen, S., Borowiak M., Fox JL, Maehr R., Osafune K., Davidow L., Lam K., Peng LF, Schreiber SL, Rubin LL, and Melton D. Nature chemical biology, 2009/04/01, Volume 5, Issue 4, p.258-65, (2009) Read More / View Supplemental Materials
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Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.Kelly, KA, Shaw SY, Nahrendorf M., Kristoff K., Aikawa E., Schreiber SL, Clemons PA, and Weissleder R. Integrative biology : quantitative biosciences from nano to macro, 2009/04/01, Volume 1, Issue 4, p.311-7, (2009) Read More / View Supplemental Materials
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Identifying the proteins to which small-molecule probes and drugs bind in cells.Ong, SE, Schenone M., Margolin AA, Li X., Do K., Doud MK, Mani D. R., Kuai L., Wang X., Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub T. R., Gould RJ, Schreiber SL, and Carr SA Proceedings of the National Academy of Sciences of the United States of America, 2009/03/24, Volume 106, Issue 12, p.4617-22, (2009) Read More / View Supplemental Materials
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Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation.Salvesen, HB, Carter SL, Mannelqvist M., Dutt A., Getz G., Stefansson IM, Raeder MB, Sos ML, Engelsen IB, Trovik J., Wik E., Greulich H., Bø TH, Jonassen I., Thomas RK, Zander T., Garraway LA, Oyan AM, Sellers WR, Kalland KH, et al. Proceedings of the National Academy of Sciences of the United States of America, 2009/03/24, Volume 106, Issue 12, p.4834-9, (2009) Read More / View Supplemental Materials
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Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.Mao, Y., Ge X., Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C., Berry EM, Soda T., Singh KK, Biechele T., Petryshen TL, Moon RT, Haggarty SJ, and Tsai LH Cell, 2009/03/20, Volume 136, Issue 6, p.1017-31, (2009) Read More / View Supplemental Materials
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Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.Bowers, AA, West N., Newkirk TL, Troutman-Youngman AE, Schreiber SL, Wiest O., Bradner JE, and Williams RM Organic letters, 2009/03/19, Volume 11, Issue 6, p.1301-4, (2009) Read More / View Supplemental Materials
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals.Guttman, M., Amit I., Garber M., French C., Lin MF, Feldser D., Huarte M., Zuk O., Carey BW, Cassady JP, Cabili MN, Jaenisch R., Mikkelsen TS, Jacks T., Hacohen N., Bernstein BE, Kellis M., Regev A., Rinn JL, and Lander E. S. Nature, 2009/03/12, Volume 458, Issue 7235, p.223-7, (2009) Read More / View Supplemental Materials
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Prolonged therapy for hepatitis C with low-dose peginterferon.Hoshida, Y., and Golub T. R. The New England journal of medicine, 2009/03/12, Volume 360, Issue 11, p.1152; author reply 1152-3, (2009) Read More / View Supplemental Materials
Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.Bowers, AA, Greshock TJ, West N., Estiu G., Schreiber SL, Wiest O., Williams RM, and Bradner JE Journal of the American Chemical Society, 2009/03/04, Volume 131, Issue 8, p.2900-5, (2009) Read More / View Supplemental Materials
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A small molecule that binds Hedgehog and blocks its signaling in human cells.Stanton, BZ, Peng LF, Maloof N., Nakai K., Wang X., Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A., and Schreiber SL Nature chemical biology, 2009/03/01, Volume 5, Issue 3, p.154-6, (2009) Read More / View Supplemental Materials
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Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning.Jones, TR, Carpenter AE, Lamprecht MR, Moffat J., Silver SJ, Grenier JK, Castoreno AB, Eggert US, Root DE, Golland P., and Sabatini DM Proceedings of the National Academy of Sciences of the United States of America, 2009/02/10, Volume 106, Issue 6, p.1826-31, (2009) Read More / View Supplemental Materials
Abstract
Prediction of high-responding peptides for targeted protein assays by mass spectrometry.Fusaro, VA, Mani D. R., Mesirov J. P., and Carr SA Nature biotechnology, 2009/02/01, Volume 27, Issue 2, p.190-8, (2009) Read More / View Supplemental Materials
Abstract
Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing.Gnirke, A., Melnikov A., Maguire J., Rogov P., LeProust EM, Brockman W., Fennell T., Giannoukos G., Fisher S., Russ C., Gabriel S., Jaffe DB, Lander E. S., and Nusbaum C. Nature biotechnology, 2009/02/01, Volume 27, Issue 2, p.182-9, (2009) Read More / View Supplemental Materials
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Organic chemistry: Molecular diversity by design.Schreiber, SL Nature, 2009/01/08, Volume 457, Issue 7226, p.153-4, (2009) Read More / View Supplemental Materials
The state of the art of chemical biology.Altmann, KH, Buchner J., Kessler H., Diederich F., Kräutler B., Lippard S., Liskamp R., Müller K., Nolan EM, Samori B., Schneider G., Schreiber SL, Schwalbe H., Toniolo C., van Boeckel CA, Waldmann H., and Walsh CT Chembiochem : a European journal of chemical biology, 2009/01/05, Volume 10, Issue 1, p.16-29, (2009) Read More / View Supplemental Materials
ALLPATHS 2: small genomes assembled accurately and with high continuity from short paired reads.Maccallum, I., Przybylski D., Gnerre S., Burton J., Shlyakhter I., Gnirke A., Malek J., McKernan K., Ranade S., Shea TP, Williams L., Young S., Nusbaum C., and Jaffe DB Genome biology, 2009/01/01, Volume 10, Issue 10, p.R103, (2009) Read More / View Supplemental Materials
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Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy.Du, J., Bernasconi P., Clauser KR, Mani D. R., Finn SP, Beroukhim R., Burns M., Julian B., Peng XP, Hieronymus H., Maglathlin RL, Lewis TA, Liau LM, Nghiemphu P., Mellinghoff IK, Louis DN, Loda M., Carr SA, Kung AL, and Golub T. R. Nature biotechnology, 2009/01/01, Volume 27, Issue 1, p.77-83, (2009) Read More / View Supplemental Materials
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Closing gaps in the human genome using sequencing by synthesis.Garber, M., Zody MC, Arachchi HM, Berlin A., Gnerre S., Green LM, Lennon N., and Nusbaum C. Genome biology, 2009/01/01, Volume 10, Issue 6, p.R60, (2009) Read More / View Supplemental Materials
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High-resolution mapping of copy-number alterations with massively parallel sequencing.Chiang, DY, Getz G., Jaffe DB, O'Kelly MJ, Zhao X., Carter SL, Russ C., Nusbaum C., Meyerson M., and Lander E. S. Nature methods, 2009/01/01, Volume 6, Issue 1, p.99-103, (2009) Read More / View Supplemental Materials
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Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing.Nusbaum, C., Ohsumi TK, Gomez J., Aquadro J., Victor TC, Warren RM, Hung DT, Birren BW, Lander E. S., and Jaffe DB Nature methods, 2009/01/01, Volume 6, Issue 1, p.67-9, (2009) Read More / View Supplemental Materials
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SNP genotyping using the Sequenom MassARRAY iPLEX platform.Gabriel, S., Ziaugra L., and Tabbaa D. Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.], 2009/01/01, Volume Chapter 2, p.Unit 2.12, (2009) Read More / View Supplemental Materials
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2008
Highly parallel identification of essential genes in cancer cells.Luo, B., Cheung HW, Subramanian A., Sharifnia T., Okamoto M., Yang X., Hinkle G., Boehm JS, Beroukhim R., Weir BA, Mermel C., Barbie DA, Awad T., Zhou X., Nguyen T., Piqani B., Li C., Golub T. R., Meyerson M., Hacohen N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2008/12/23, Volume 105, Issue 51, p.20380-5, (2008) Read More / View Supplemental Materials
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Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.Shao, H., Burrage LC, Sinasac DS, Hill AE, Ernest SR, O'Brien W., Courtland HW, Jepsen KJ, Kirby A., Kulbokas E. J., Daly M. J., Broman KW, Lander E. S., and Nadeau JH Proceedings of the National Academy of Sciences of the United States of America, 2008/12/16, Volume 105, Issue 50, p.19910-4, (2008) Read More / View Supplemental Materials
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Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum.Martyn, DC, Ramirez AP, Beattie MJ, Cortese JF, Patel V., Rush MA, Woerpel KA, and Clardy J. Bioorganic & medicinal chemistry letters, 2008/12/15, Volume 18, Issue 24, p.6521-4, (2008) Read More / View Supplemental Materials
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Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients.Kuntzen, T., Timm J., Berical A., Lennon N., Berlin AM, Young SK, Lee B., Heckerman D., Carlson J., Reyor LL, Kleyman M., McMahon CM, Birch C., Schulze Zur Wiesch J., Ledlie T., Koehrsen M., Kodira C., Roberts AD, Lauer GM, Rosen HR, et al. Hepatology (Baltimore, Md.), 2008/12/01, Volume 48, Issue 6, p.1769-78, (2008) Read More / View Supplemental Materials
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Nodal signaling promotes the speed and directional movement of cardiomyocytes in zebrafish.de Campos-Baptista, MI, Holtzman NG, Yelon D., and Schier AF Developmental dynamics : an official publication of the American Association of Anatomists, 2008/12/01, Volume 237, Issue 12, p.3624-33, (2008) Read More / View Supplemental Materials
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