Scientific Publications

Search by Keyword(s)
Found 3459 results

Search Results

2015
Tools and best practices for data processing in allelic expression analysis.Castel, SE, Levy-Moonshine A., Mohammadi P., Banks E., and Lappalainen T. Genome biology, 2015/09/17, Volume 16, Issue 1, p.195, (2015) Read More / View Supplemental Materials
Abstract
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.Canver, MC, Smith EC, Sher F., Pinello L., Sanjana NE, Shalem O., Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S., Kurita R., Nakamura Y., Fujiwara Y., Maeda T., Yuan GC, Zhang F., Orkin SH, and Bauer DE Nature, 2015/09/16, (2015) Read More / View Supplemental Materials
Abstract
De novo mutations in ARID1B associated with both syndromic and non-syndromic short stature.Yu, Y., Yao R., Wang L., Fan Y., Huang X., Hirschhorn J., Dauber A., and Shen Y. BMC genomics, 2015/09/16, Volume 16, Issue 1, p.701, (2015) Read More / View Supplemental Materials
Abstract
Gene-Based Meta-Analysis of Genome-Wide Association Studies Implicates New Loci Involved in Obesity.Hägg, S., Ganna A., van der Laan SW, Esko T., Pers TH, Locke AE, Berndt SI, Justice AE, Kahali B., Siemelink MA, Pasterkamp G., GIANT Consortium, Strachan DP, Speliotes EK, North KE, Loos RJ, Hirschhorn JN, Pawitan Y., and Ingelsson E. Human molecular genetics, 2015/09/16, (2015) Read More / View Supplemental Materials
Abstract
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.Pelleau, S., Moss EL, Dhingra SK, Volney B., Casteras J., Gabryszewski SJ, Volkman SK, Wirth DF, Legrand E., Fidock DA, Neafsey DE, and Musset L. Proceedings of the National Academy of Sciences of the United States of America, 2015/09/15, Volume 112, Issue 37, p.11672-7, (2015) Read More / View Supplemental Materials
Abstract
Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes.Shukla, SA, Rooney MS, Rajasagi M., Tiao G., Dixon PM, Lawrence MS, Lane WJ, Steelman S., Sougnez C., Cibulskis K., Kiezun A., Hacohen N., Brusic V., Wu CJ, and Getz G. Nature biotechnology, 2015/09/15, (2015) Read More / View Supplemental Materials
Abstract
Host genetic variation impacts microbiome composition across human body sites.Blekhman, R., Goodrich JK, Huang K., Sun Q., Bukowski R., Bell JT, Spector TD, Keinan A., Ley RE, Gevers D., and Clark AG Genome biology, 2015/09/15, Volume 16, p.191, (2015) Read More / View Supplemental Materials
Abstract
Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.Ghani, M., Reitz C., Cheng R., Vardarajan BN, Jun G., Sato C., Naj A., Rajbhandary R., Wang LS, Valladares O., Lin CF, Larson EB, Graff-Radford NR, Evans D., De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T., Ertekin-Taner N., et al. JAMA neurology, 2015/09/14, (2015) Read More / View Supplemental Materials
Abstract
Detection of low-abundance bacterial strains in metagenomic datasets by eigengenome partitioning.Cleary, B., Brito IL, Huang K., Gevers D., Shea T., Young S., and Alm EJ Nature biotechnology, 2015/09/14, (2015) Read More / View Supplemental Materials
Abstract
Population genetic differentiation of height and body mass index across Europe.Robinson, MR, Hemani G., Medina-Gomez C., Mezzavilla M., Esko T., Shakhbazov K., Powell JE, Vinkhuyzen A., Berndt SI, Gustafsson S., Justice AE, Kahali B., Locke AE, Pers TH, Vedantam S., Wood AR, van Rheenen W., Andreassen OA, Gasparini P., Metspalu A., et al. Nature genetics, 2015/09/14, (2015) Read More / View Supplemental Materials
Abstract
Zebrafish as tools for drug discovery.Macrae, CA, and Peterson RT Nature reviews. Drug discovery, 2015/09/11, (2015) Read More / View Supplemental Materials
Abstract
Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.Avraham, R., Haseley N., Brown D., Penaranda C., Jijon HB, Trombetta JJ, Satija R., Shalek AK, Xavier RJ, Regev A., and Hung DT Cell, 2015/09/10, Volume 162, Issue 6, p.1309-21, (2015) Read More / View Supplemental Materials
Abstract
Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.Johnston, AJ, Murphy KT, Jenkinson L., Laine D., Emmrich K., Faou P., Weston R., Jayatilleke KM, Schloegel J., Talbo G., Casey JL, Levina V., Wong WW, Dillon H., Sahay T., Hoogenraad J., Anderton H., Hall C., Schneider P., Tanzer M., et al. Cell, 2015/09/10, Volume 162, Issue 6, p.1365-78, (2015) Read More / View Supplemental Materials
Abstract
Mechanisms of Cancer Cell Dormancy-Another Hallmark of Cancer?Yeh, AC, and Ramaswamy S. Cancer research, 2015/09/09, (2015) Read More / View Supplemental Materials
Abstract
Phenotypic extremes in rare variant study designs.Peloso, GM, Rader DJ, Gabriel S., Kathiresan S., Daly M. J., and Neale BM European journal of human genetics : EJHG, 2015/09/09, (2015) Read More / View Supplemental Materials
Abstract
Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells.Yang, BX, El Farran CA, Guo HC, Yu T., Fang HT, Wang HF, Schlesinger S., Seah YF, Goh GY, Neo SP, Li Y., Lorincz MC, Tergaonkar V., Lim TM, Chen L., Gunaratne J., Collins JJ, Goff SP, Daley GQ, Li H., et al. Cell, 2015/09/09, (2015) Read More / View Supplemental Materials
Abstract
Combined pan-RAF and MEK inhibition overcomes multiple resistance mechanisms to selective RAF inhibitors.Whittaker, SR, Cowley GS, Wagner S., Root DE, and Garraway LA Molecular cancer therapeutics, 2015/09/08, (2015) Read More / View Supplemental Materials
Abstract
Fossil hominin shoulders support an African ape-like last common ancestor of humans and chimpanzees.Young, NM, Capellini TD, Roach NT, and Alemseged Z. Proceedings of the National Academy of Sciences of the United States of America, 2015/09/08, (2015) Read More / View Supplemental Materials
Abstract
A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.Selleck, EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B., Virgin HW, and Sibley LD mBio, 2015/09/08, Volume 6, Issue 5, (2015) Read More / View Supplemental Materials
Abstract
Cas9 gRNA engineering for genome editing, activation and repression.Kiani, S., Chavez A., Tuttle M., Hall RN, Chari R., Ter-Ovanesyan D., Qian J., Pruitt BW, Beal J., Vora S., Buchthal J., Kowal EJ, Ebrahimkhani MR, Collins JJ, Weiss R., and Church G. Nature methods, 2015/09/07, (2015) Read More / View Supplemental Materials
Abstract
ConStrains identifies microbial strains in metagenomic datasets.Luo, C., Knight R., Siljander H., Knip M., Xavier RJ, and Gevers D. Nature biotechnology, 2015/09/07, (2015) Read More / View Supplemental Materials
Abstract
Modeling psychiatric disorders for developing effective treatments.Kaiser, T., and Feng G. Nature medicine, 2015/09/04, Volume 21, Issue 9, p.979-88, (2015) Read More / View Supplemental Materials
Abstract
A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation.Sun, J., Bonaguidi MA, Jun H., Guo JU, Sun GJ, Will B., Yang Z., Jang MH, Song H., Ming GL, and Christian KM Molecular brain, 2015/09/04, Volume 8, Issue 1, p.52, (2015) Read More / View Supplemental Materials
Abstract
Theory of mind network activity is altered in subjects with familial liability for schizophrenia.Mohnke, S., Erk S., Schnell K., Romanczuk-Seiferth N., Schmierer P., Romund L., Garbusow M., Wackerhagen C., Ripke S., Grimm O., Haller L., Witt SH, Degenhardt F., Tost H., Heinz A., Meyer-Lindenberg A., and Walter H. Social cognitive and affective neuroscience, 2015/09/04, (2015) Read More / View Supplemental Materials
Abstract
Comparative Analysis of Gene Regulatory Networks: From Network Reconstruction to Evolution.Thompson, D., Regev A., and Roy S. Annual review of cell and developmental biology, 2015/09/03, (2015) Read More / View Supplemental Materials
Abstract
Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders.Hyman, SE Cell stem cell, 2015/09/03, Volume 17, Issue 3, p.253-4, (2015) Read More / View Supplemental Materials
Abstract
Identification of an oncogenic RAB protein.Wheeler, DB, Zoncu R., Root DE, Sabatini DM, and Sawyers CL Science (New York, N.Y.), 2015/09/03, (2015) Read More / View Supplemental Materials
Abstract
Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance.Li, M., Luo XJ, Landén M., Bergen SE, Hultman CM, Li X., Zhang W., Yao YG, Zhang C., Liu J., Mattheisen M., Cichon S., Mühleisen TW, Degenhardt FA, Nöthen MM, Schulze TG, Grigoroiu-Serbanescu M., Li H., Fuller CK, Chen C., et al. The British journal of psychiatry : the journal of mental science, 2015/09/03, (2015) Read More / View Supplemental Materials
Abstract
Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma.Sim, K., Graef AJ, Breen M., Lindblad-Toh K., Modiano JF, and Kim JH Veterinary and comparative oncology, 2015/09/03, (2015) Read More / View Supplemental Materials
Abstract
Sequence-Level Analysis of the Major European Huntington Disease Haplotype.Lee, JM, Kim KH, Shin A., Chao MJ, Abu Elneel K., Gillis T., Mysore JS, Kaye JA, Zahed H., Kratter IH, Daub AC, Finkbeiner S., Li H., Roach JC, Goodman N., Hood L., Myers RH, Macdonald ME, and Gusella JF American journal of human genetics, 2015/09/03, Volume 97, Issue 3, p.435-44, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans.Hsu, YH, Liu Y., Hannan MT, Maixner W., Smith SB, Diatchenko L., Golightly YM, Menz HB, Kraus VB, Doherty M., Wilson AG, and Jordan JM Journal of medical genetics, 2015/09/02, (2015) Read More / View Supplemental Materials
Abstract
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.Gan, W., Dai X., Lunardi A., Li Z., Inuzuka H., Liu P., Varmeh S., Zhang J., Cheng L., Sun Y., Asara JM, Beck AH, Huang J., Pandolfi PP, and Wei W. Molecular cell, 2015/09/02, (2015) Read More / View Supplemental Materials
Abstract
Deep, Quantitative Coverage of the Lysine Acetylome Using Novel Anti-acetyl-lysine Antibodies and an Optimized Proteomic Workflow.Svinkina, T., Gu H., Silva JC, Mertins P., Qiao J., Fereshetian S., Jaffe JD, Kuhn E., Udeshi ND, and Carr SA Molecular & cellular proteomics : MCP, 2015/09/01, Volume 14, Issue 9, p.2429-40, (2015) Read More / View Supplemental Materials
Abstract
Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.Nühs, A., De Rycker M., Manthri S., Comer E., Scherer CA, Schreiber SL, Ioset JR, and Gray DW PLoS neglected tropical diseases, 2015/09/01, Volume 9, Issue 9, p.e0004094, (2015) Read More / View Supplemental Materials
Abstract
Epidemiologic Investigation of a Cluster of Neuroinvasive Bacillus cereus Infections in 5 Patients With Acute Myelogenous Leukemia.Rhee, C., Klompas M., Tamburini FB, Fremin BJ, Chea N., Epstein L., Halpin AL, Guh A., Gallen R., Coulliette A., Gee J., Hsieh C., Desjardins CA, Pedamullu CS, DeAngelo DJ, Manzo VE, Folkerth RD, Milner DA Jr, Pecora N., Osborne M., et al. Open forum infectious diseases, 2015/09/01, Volume 2, Issue 3, p.ofv096, (2015) Read More / View Supplemental Materials
Abstract
Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal.Cohen, KA, Abeel T., Manson McGuire A., Desjardins CA, Munsamy V., Shea TP, Walker BJ, Bantubani N., Almeida DV, Alvarado L., Chapman SB, Mvelase NR, Duffy EY, FitzGerald MG, Govender P., Gujja S., Hamilton S., Howarth C., Larimer JD, Maharaj K., et al. PLoS medicine, 2015/09/01, Volume 12, Issue 9, p.e1001880, (2015) Read More / View Supplemental Materials
Abstract
Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii.Farrer, RA, Desjardins CA, Sakthikumar S., Gujja S., Saif S., Zeng Q., Chen Y., Voelz K., Heitman J., May RC, Fisher MC, and Cuomo CA mBio, 2015/09/01, Volume 6, Issue 5, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide Polygenic Burden of Rare Deleterious Variants in Sudden Unexpected Death in Epilepsy.Leu, C., Balestrini S., Maher B., Hernández-Hernández L., Gormley P., Hämäläinen E., Heggeli K., Schoeler N., Novy J., Willis J., Plagnol V., Ellis R., Reavey E., O'Regan M., Pickrell WO, Thomas RH, Chung SK, Delanty N., McMahon JM, Malone S., et al. EBioMedicine, 2015/09/01, Volume 2, Issue 9, p.1063-70, (2015) Read More / View Supplemental Materials
Abstract
High loading of polygenic risk in cases with chronic schizophrenia.Meier, SM, Agerbo E., Maier R., Pedersen CB, Lang M., Grove J., Hollegaard MV, Demontis D., Trabjerg BB, Hjorthøj C., Ripke S., Degenhardt F., Nöthen MM, Rujescu D., Maier W., MooDS SCZ Consortium, Werge T., Mors O., Hougaard DM, Børglum AD, et al. Molecular psychiatry, 2015/09/01, (2015) Read More / View Supplemental Materials
Abstract
Inherited CHST11/MIR3922 deletion is associated with a novel recessive syndrome presenting with skeletal malformation and malignant lymphoproliferative disease.Chopra, SS, Leshchiner I., Duzkale H., McLaughlin H., Giovanni M., Zhang C., Stitziel N., Fingeroth J., Joyce RM, Lebo M., Rehm H., Vuzman D., Maas R., Sunyaev SR, Murray M., and Cassa CA Molecular genetics & genomic medicine, 2015/09/01, Volume 3, Issue 5, p.413-23, (2015) Read More / View Supplemental Materials
Abstract
Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.Abbatiello, SE, Schilling B., Mani D. R., Zimmerman LJ, Hall SC, Maclean B., Albertolle M., Allen S., Burgess M., Cusack MP, Gosh M., Hedrick V., Held JM, Inerowicz HD, Jackson A., Keshishian H., Kinsinger CR, Lyssand J., Makowski L., Mesri M., et al. Molecular & cellular proteomics : MCP, 2015/09/01, Volume 14, Issue 9, p.2357-74, (2015) Read More / View Supplemental Materials
Abstract
The metabolomics of asthma control: a promising link between genetics and disease.McGeachie, MJ, Dahlin A., Qiu W., Croteau-Chonka DC, Savage J., Wu AC, Wan ES, Sordillo JE, Al-Garawi A., Martinez FD, Strunk RC, Lemanske RF Jr, Liu AH, Raby BA, Weiss S., Clish CB, and Lasky-Su JA Immunity, inflammation and disease, 2015/09/01, Volume 3, Issue 3, p.224-38, (2015) Read More / View Supplemental Materials
Abstract
The molecular era of the mitochondrial calcium uniporter.Kamer, KJ, and Mootha VK Nature reviews. Molecular cell biology, 2015/09/01, Volume 16, Issue 9, p.545-53, (2015) Read More / View Supplemental Materials
Abstract
Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.Keshishian, H., Burgess MW, Gillette MA, Mertins P., Clauser KR, Mani D. R., Kuhn EW, Farrell LA, Gerszten RE, and Carr SA Molecular & cellular proteomics : MCP, 2015/09/01, Volume 14, Issue 9, p.2375-93, (2015) Read More / View Supplemental Materials
Abstract
Ribosomopathies: how a common root can cause a tree of pathologies.Danilova, N., and Gazda HT Disease models & mechanisms, 2015/09/01, Volume 8, Issue 9, p.1013-26, (2015) Read More / View Supplemental Materials
Abstract
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.Yang, J., Bakshi A., Zhu Z., Hemani G., Vinkhuyzen AA, Lee SH, Robinson MR, Perry JR, Nolte IM, van Vliet-Ostaptchouk JV, Snieder H., study LifeLines Cohort, Esko T., Milani L., Mägi R., Metspalu A., Hamsten A., Magnusson PK, Pedersen NL, Ingelsson E., et al. Nature genetics, 2015/08/31, (2015) Read More / View Supplemental Materials
Abstract
The Genetics of Stress-Related Disorders: PTSD, Depression and Anxiety Disorders.Smoller, JW Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015/08/31, (2015) Read More / View Supplemental Materials
Abstract
Sequence Analysis and Characterization of Active Human Alu subfamilies Based on the 1000 Genomes Pilot Project.Konkel, MK, Walker JA, Hotard AB, Ranck MC, Fontenot CC, Storer J., Stewart C., Marth GT, 1000 Genomes Consortium, and Batzer MA Genome biology and evolution, 2015/08/29, (2015) Read More / View Supplemental Materials
Abstract
Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation.Zhang, Z., Boskovic Z., Hussain MM, Hu W., Inouye C., Kim HJ, Abole AK, Doud MK, Lewis TA, Koehler AN, Schreiber SL, and Tjian R. eLife, 2015/08/28, Volume 4, (2015) Read More / View Supplemental Materials
Abstract
EHMT1 and EHMT2 inhibition induce fetal hemoglobin expression.Renneville, A., van Galen P., Canver MC, McConkey M., Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, and Ebert BL Blood, 2015/08/28, (2015) Read More / View Supplemental Materials
Abstract
Ethnically shared and heterogeneous impacts of molecular pathways suggested by the genome-wide meta-analysis of rheumatoid arthritis.Okada, Y., Raj T., and Yamamoto K. Rheumatology (Oxford, England), 2015/08/28, (2015) Read More / View Supplemental Materials
In vitro and in vivo reprogramming for the conduction system.Macrae, CA Trends in cardiovascular medicine, 2015/08/28, (2015) Read More / View Supplemental Materials
Transgenic labeling of parvalbumin-expressing neurons with tdTomato.Kaiser, T., Ting JT, Monteiro P., and Feng G. Neuroscience, 2015/08/28, (2015) Read More / View Supplemental Materials
Abstract
Crystal Structure of Staphylococcus aureus Cas9.Nishimasu, H., Cong L., Yan WX, Ran FA, Zetsche B., Li Y., Kurabayashi A., Ishitani R., Zhang F., and Nureki O. Cell, 2015/08/27, Volume 162, Issue 5, p.1113-26, (2015) Read More / View Supplemental Materials
Abstract
Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis.Hiraki, M., Hwang SY, Cao S., Ramadhar TR, Byun S., Yoon KW, Lee JH, Chu K., Gurkar AU, Kolev V., Zhang J., Namba T., Murphy ME, Newman DJ, Mandinova A., Clardy J., and Lee SW Chemistry & biology, 2015/08/27, (2015) Read More / View Supplemental Materials
Abstract
Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis.Mima, K., Nishihara R., Qian ZR, Cao Y., Sukawa Y., Nowak JA, Yang J., Dou R., Masugi Y., Song M., Kostic AD, Giannakis M., Bullman S., Milner DA, Baba H., Giovannucci EL, Garraway LA, Freeman GJ, Dranoff G., Garrett WS, et al. Gut, 2015/08/26, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy.Ng, SY, Soh BS, Rodriguez-Muela N., Hendrickson DG, Price F., Rinn JL, and Rubin LL Cell stem cell, 2015/08/26, (2015) Read More / View Supplemental Materials
Abstract
Commissural functional topography of the inferior colliculus assessed in vitro.Lee, CC, Yanagawa Y., and Imaizumi K. Hearing research, 2015/08/25, (2015) Read More / View Supplemental Materials
Abstract
Comparative genomics of Fusarium oxysporum f. sp. melonis reveals the secreted protein recognized by the Fom-2 resistance gene in melon.Schmidt, SM, Lukasiewicz J., Farrer R., van Dam P., Bertoldo C., and Rep M. The New phytologist, 2015/08/25, (2015) Read More / View Supplemental Materials
Abstract
Genetic association analyses highlight biological pathways underlying mitral valve prolapse.Dina, C., Bouatia-Naji N., Tucker N., Delling FN, Toomer K., Durst R., Perrocheau M., Fernandez-Friera L., Solis J., investigators PROMESA, Le Tourneau T., Chen MH, Probst V., Bosse Y., Pibarot P., Zelenika D., Lathrop M., Hercberg S., Roussel R., Benjamin EJ, et al. Nature genetics, 2015/08/24, (2015) Read More / View Supplemental Materials
Abstract
In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer.Janiszewska, M., Liu L., Almendro V., Kuang Y., Paweletz C., Sakr RA, Weigelt B., Hanker AB, Chandarlapaty S., King TA, Reis-Filho JS, Arteaga CL, Park SY, Michor F., and Polyak K. Nature genetics, 2015/08/24, (2015) Read More / View Supplemental Materials
Abstract
A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors.Nishi, Y., Zhang X., Jeong J., Peterson KA, Vedenko A., Bulyk ML, Hide WA, and McMahon AP Development (Cambridge, England), 2015/08/20, (2015) Read More / View Supplemental Materials
Abstract
Mutations in PIGY: expanding the phenotype of inherited glycosylphosphatidylinositol (GPI) deficiencies.Ilkovski, B., Pagnamenta AT, O'Grady GL, Kinoshita T., Howard MF, Lek M., Thomas B., Turner A., Christodoulou J., Sillence D., Knight SJ, Popitsch N., Keays DA, Anzilotti C., Goriely A., Waddell LB, Brilot F., North KN, Kanzawa N., Macarthur DG, et al. Human molecular genetics, 2015/08/20, (2015) Read More / View Supplemental Materials
Abstract
Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.Schweitzer, LD, Comb WC, Bar-Peled L., and Sabatini DM Cell reports, 2015/08/19, (2015) Read More / View Supplemental Materials
Abstract
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.Claussnitzer, M., Dankel SN, Kim KH, Quon G., Meuleman W., Haugen C., Glunk V., Sousa IS, Beaudry JL, Puviindran V., Abdennur NA, Liu J., Svensson PA, Hsu YH, Drucker DJ, Mellgren G., Hui CC, Hauner H., and Kellis M. The New England journal of medicine, 2015/08/19, (2015) Read More / View Supplemental Materials
Abstract
PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells.Das, PP, Hendrix DA, Apostolou E., Buchner AH, Canver MC, Beyaz S., Ljuboja D., Kuintzle R., Kim W., Karnik R., Shao Z., Xie H., Xu J., De Los Angeles A., Zhang Y., Choe J., Jun DL, Shen X., Gregory RI, Daley GQ, et al. Cell reports, 2015/08/19, (2015) Read More / View Supplemental Materials
Abstract
Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population.Xu, Q., Wu X., Li M., Huang H., Minica C., Yi Z., Wang G., Shen L., Xing Q., Shi Y., He L., and Qin S. The pharmacogenomics journal, 2015/08/18, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.Hayes, MG, Urbanek M., Ehrmann DA, Armstrong LL, Lee JY, Sisk R., Karaderi T., Barber TM, McCarthy MI, Franks S., Lindgren CM, Welt CK, Diamanti-Kandarakis E., Panidis D., Goodarzi MO, Azziz R., Zhang Y., James RG, Olivier M., Kissebah AH, et al. Nature communications, 2015/08/18, Volume 6, p.7502, (2015) Read More / View Supplemental Materials
Abstract
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.Lee, SH, Byrne EM, Hultman CM, Kähler A., Vinkhuyzen AA, Ripke S., Andreassen OA, Frisell T., Gusev A., Hu X., Karlsson R., Mantzioris VX, McGrath JJ, Mehta D., Stahl EA, Zhao Q., Kendler KS, Sullivan PF, Price AL, O'Donovan M., et al. International journal of epidemiology, 2015/08/18, (2015) Read More / View Supplemental Materials
Abstract
Systematic chromatin state comparison of epigenomes associated with diverse properties including sex and tissue type.Yen, A., and Kellis M. Nature communications, 2015/08/18, Volume 6, p.7973, (2015) Read More / View Supplemental Materials
Abstract
Clinical Effects of Phosphodiesterase 3A Mutations in Inherited Hypertension With Brachydactyly.Toka, O., Tank J., Schächterle C., Aydin A., Maass PG, Elitok S., Bartels-Klein E., Hollfinger I., Lindschau C., Mai K., Boschmann M., Rahn G., Movsesian MA, Müller T., Doescher A., Gnoth S., Mühl A., Toka HR, Wefeld-Neuenfeld Y., Utz W., et al. Hypertension, 2015/08/17, (2015) Read More / View Supplemental Materials
Abstract
Predicting facial characteristics from complex polygenic variations.Fagertun, J., Wolffhechel K., Pers TH, Nielsen HB, Gudbjartsson D., Stefansson H., Stefansson K., Paulsen RR, and Jarmer H. Forensic science international. Genetics, 2015/08/17, Volume 19, p.263-268, (2015) Read More / View Supplemental Materials
Abstract
Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.Park, E., Kim N., Ficarro SB, Zhang Y., Lee BI, Cho A., Kim K., Park AK, Park WY, Murray B., Meyerson M., Beroukhim R., Marto JA, Cho J., and Eck MJ Nature structural & molecular biology, 2015/08/17, (2015) Read More / View Supplemental Materials
Abstract
APOE and cerebral amyloid angiopathy in community-dwelling older persons.Yu, L., Boyle PA, Nag S., Leurgans S., Buchman AS, Wilson RS, Arvanitakis Z., Farfel JM, De Jager PL, Bennett DA, and Schneider JA Neurobiology of aging, 2015/08/15, (2015) Read More / View Supplemental Materials
Abstract
Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans.Garaulet, M., Gómez-Abellán P., Rubio-Sastre P., Madrid JA, Saxena R., and Scheer FA Metabolism: clinical and experimental, 2015/08/14, (2015) Read More / View Supplemental Materials
Abstract
Doxycycline: new tricks for an old drug.Barbie, DA, and Kennedy BK Oncotarget, 2015/08/14, Volume 6, Issue 23, p.19336-7, (2015) Read More / View Supplemental Materials
Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.Andersen, KG, Shapiro BJ, Matranga CB, Sealfon R., Lin AE, Moses LM, Folarin OA, Goba A., Odia I., Ehiane PE, Momoh M., England EM, Winnicki S., Branco LM, Gire SK, Phelan E., Tariyal R., Tewhey R., Omoniwa O., Fullah M., et al. Cell, 2015/08/13, Volume 162, Issue 4, p.738-50, (2015) Read More / View Supplemental Materials
Abstract
Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells.Sefik, E., Geva-Zatorsky N., Oh S., Konnikova L., Zemmour D., McGuire AM, Burzyn D., Ortiz-Lopez A., Lobera M., Yang J., Ghosh S., Earl A., Snapper SB, Jupp R., Kasper D., Mathis D., and Benoist C. Science (New York, N.Y.), 2015/08/13, (2015) Read More / View Supplemental Materials
Abstract
Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success.Choi, EK, Park JH, Lee JY, Nam CM, Hwang MK, Uhm JS, Joung B., Ko YG, Lee MH, Lubitz SA, Ellinor PT, and Pak HN Journal of the American Heart Association, 2015/08/13, Volume 4, Issue 8, (2015) Read More / View Supplemental Materials
Abstract
GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.Ramanan, VK, Risacher SL, Nho K., Kim S., Shen L., McDonald BC, Yoder KK, Hutchins GD, West JD, Tallman EF, Gao S., Foroud TM, Farlow MR, De Jager PL, Bennett DA, Aisen PS, Petersen RC, Jack CR Jr, Toga AW, Green RC, et al. Brain : a journal of neurology, 2015/08/11, (2015) Read More / View Supplemental Materials
Abstract
Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.Morris, RW, Taylor AE, Fluharty ME, Bjørngaard JH, Åsvold BO, Elvestad Gabrielsen M., Campbell A., Marioni R., Kumari M., Korhonen T., Männistö S., Marques-Vidal P., Kaakinen M., Cavadino A., Postmus I., Husemoen LL, Skaaby T., Ahluwalia TV, Treur JL, Willemsen G., et al. BMJ open, 2015/08/11, Volume 5, Issue 8, p.e008808, (2015) Read More / View Supplemental Materials
Abstract
An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.Chan, K., Roberts SA, Klimczak LJ, Sterling JF, Saini N., Malc EP, Kim J., Kwiatkowski DJ, Fargo DC, Mieczkowski PA, Getz G., and Gordenin DA Nature genetics, 2015/08/10, (2015) Read More / View Supplemental Materials
Abstract
Malaria Molecular Epidemiology: Lessons from the International Centers of Excellence for Malaria Research Network.Escalante, AA, Ferreira MU, Vinetz JM, Volkman SK, Cui L., Gamboa D., Krogstad DJ, Barry AE, Carlton JM, van Eijk AM, Pradhan K., Mueller I., Greenhouse B., Pacheco MA, Vallejo AF, Herrera S., and Felger I. The American journal of tropical medicine and hygiene, 2015/08/10, (2015) Read More / View Supplemental Materials
Abstract
Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research.Carlton, JM, Volkman SK, Uplekar S., Hupalo DN, Pereira Alves JM, Cui L., Donnelly M., Roos DS, Harb OS, Acosta M., Read A., Ribolla PE, Singh OP, Valecha N., Wassmer SC, Ferreira M., and Escalante AA The American journal of tropical medicine and hygiene, 2015/08/10, (2015) Read More / View Supplemental Materials
Abstract
Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.Lenz, TL, Deutsch AJ, Han B., Hu X., Okada Y., Eyre S., Knapp M., Zhernakova A., Huizinga TW, Abecasis G., Becker J., Boeckxstaens GE, Chen WM, Franke A., Gladman DD, Gockel I., Gutierrez-Achury J., Martin J., Nair RP, Nöthen MM, et al. Nature genetics, 2015/08/10, (2015) Read More / View Supplemental Materials
Abstract
Genetic predisposition to weight loss & regain with lifestyle intervention: analyses from the Diabetes Prevention Program & the Look AHEAD randomized controlled trials.Papandonatos, GD, Pan Q., Pajewski NM, Delahanty LM, Peter I., Erar B., Ahmad S., Harden M., Chen L., Fontanillas P., GIANT Consortium, Wagenknecht LE, Kahn SE, Wing RR, Jablonski KA, Huggins GS, Knowler WC, Florez JC, McCaffery JM, Franks PW, et al. Diabetes, 2015/08/07, (2015) Read More / View Supplemental Materials
Abstract
A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination.Wang, AT, Kim T., Wagner JE, Conti BA, Lach FP, Huang AL, Molina H., Sanborn EM, Zierhut H., Cornes BK, Abhyankar A., Sougnez C., Gabriel SB, Auerbach AD, Kowalczykowski SC, and Smogorzewska A. Molecular cell, 2015/08/06, Volume 59, Issue 3, p.478-90, (2015) Read More / View Supplemental Materials
Abstract
Global diversity, population stratification, and selection of human copy number variation.Sudmant, PH, Mallick S., Nelson BJ, Hormozdiari F., Krumm N., Huddleston J., Coe BP, Baker C., Nordenfelt S., Bamshad M., Jorde LB, Posukh OL, Sahakyan H., Watkins WS, Yepiskoposyan L., Abdullah MS, Bravi CM, Capelli C., Hervig T., Wee JT, et al. Science (New York, N.Y.), 2015/08/06, (2015) Read More / View Supplemental Materials
Abstract
Rheumatoid factor is associated with the distribution of hand joint destruction in rheumatoid arthritis.Terao, C., Yamakawa N., Yano K., Markusse IM, Ikari K., Yoshida S., Furu M., Hashimoto M., Ito H., Fujii T., Ohmura K., Murakami K., Takahashi M., Hamaguchi M., Tabara Y., Taniguchi A., Momohara S., Raychaudhuri S., Allaart CF, Yamanaka H., et al. Arthritis & rheumatology (Hoboken, N.J.), 2015/08/05, (2015) Read More / View Supplemental Materials
Abstract
Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution.Laughney, AM, Elizalde S., Genovese G., and Bakhoum SF Cell reports, 2015/08/04, Volume 12, Issue 5, p.809-820, (2015) Read More / View Supplemental Materials
Abstract
Hypoxia-Mediated Increases in l-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.Oldham, WM, Clish CB, Yang Y., and Loscalzo J. Cell metabolism, 2015/08/04, Volume 22, Issue 2, p.291-303, (2015) Read More / View Supplemental Materials
Abstract
Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.Ma, S., Yim SH, Lee SG, Kim EB, Lee SR, Chang KT, Buffenstein R., Lewis KN, Park TJ, Miller RA, Clish CB, and Gladyshev VN Cell metabolism, 2015/08/04, Volume 22, Issue 2, p.332-43, (2015) Read More / View Supplemental Materials
Abstract
Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes.Bhatt, S., Gupta MK, Khamaisi M., Martinez R., Gritsenko MA, Wagner BK, Guye P., Busskamp V., Shirakawa J., Wu G., Liew CW, Clauss TR, Valdez I., El Ouaamari A., Dirice E., Takatani T., Keenan HA, Smith RD, Church G., Weiss R., et al. Cell metabolism, 2015/08/04, Volume 22, Issue 2, p.239-52, (2015) Read More / View Supplemental Materials
Abstract
Rare coding variants and X-linked loci associated with age at menarche.Lunetta, KL, Day FR, Sulem P., Ruth KS, Tung JY, Hinds DA, Esko T., Elks CE, Altmaier E., He C., Huffman JE, Mihailov E., Porcu E., Robino A., Rose LM, Schick UM, Stolk L., Teumer A., Thompson DJ, Traglia M., et al. Nature communications, 2015/08/04, Volume 6, p.7756, (2015) Read More / View Supplemental Materials
Abstract
Rare variants in the notch signaling pathway describe a novel type of autosomal recessive Klippel-Feil syndrome.Karaca, E., Yuregir OO, Bozdogan ST, Aslan H., Pehlivan D., Jhangiani SN, Akdemir ZC, Gambin T., Bayram Y., Atik MM, Erdin S., Muzny D., Gibbs RA, Lupski JR, and Baylor-Hopkins Center for Mendelian Genomics American journal of medical genetics. Part A, 2015/08/04, (2015) Read More / View Supplemental Materials
Abstract
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.Paull, D., Sevilla A., Zhou H., Hahn AK, Im HK, Napolitano C., Tsankov A., Shang L., Krumholz K., Jagadeesan P., Woodard CM, Sun B., Vilboux T., Zimmer M., Forero E., Moroziewicz DN, Martinez H., Malicdan MC, Weiss KA, Vensand LB, et al. Nature methods, 2015/08/03, (2015) Read More / View Supplemental Materials
Abstract
Improved canine exome designs, featuring ncRNAs and increased coverage of protein coding genes.Broeckx, BJ, Hitte C., Coopman F., Verhoeven GE, De Keulenaer S., De Meester E., Derrien T., Alfoldi J., Lindblad-Toh K., Bosmans T., Gielen I., Van Bree H., Van Ryssen B., Saunders JH, Van Nieuwerburgh F., and Deforce D. Scientific reports, 2015/08/03, Volume 5, p.12810, (2015) Read More / View Supplemental Materials
Abstract
Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck.Balick, DJ, Do R., Cassa CA, Reich D., and Sunyaev SR PLoS genetics, 2015/08/01, Volume 11, Issue 8, p.e1005436, (2015) Read More / View Supplemental Materials
Abstract
ERBB2 Emerges as a New Target for Colorectal Cancer.Pectasides, E., and Bass AJ Cancer discovery, 2015/08/01, Volume 5, Issue 8, p.799-801, (2015) Read More / View Supplemental Materials
Abstract
A roadmap for interpreting (13)C metabolite labeling patterns from cells.Buescher, JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H., Clish CB, DeBerardinis RJ, Feron O., Frezza C., Ghesquiere B., Gottlieb E., Hiller K., Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C., et al. Current opinion in biotechnology, 2015/08/01, Volume 34, p.189-201, (2015) Read More / View Supplemental Materials
Abstract