Scientific Publications

Search by Keyword(s)
Found 1956 results

Search Results

2013
Target identification and mechanism of action in chemical biology and drug discovery.Schenone, M., Dančík V., Wagner BK, and Clemons PA Nature chemical biology, 2013/04/01, Volume 9, Issue 4, p.232-40, (2013) Read More / View Supplemental Materials
Abstract
IKKε-Mediated Tumorigenesis Requires K63-Linked Polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 Ubiquitin Ligase Complex.Zhou, AY, Shen RR, Kim E., Lock YJ, Xu M., Chen ZJ, and Hahn WC Cell reports, 2013/03/28, Volume 3, Issue 3, p.724-33, (2013) Read More / View Supplemental Materials
Abstract
Lessons from the cancer genome.Garraway, LA, and Lander E. S. Cell, 2013/03/28, Volume 153, Issue 1, p.17-37, (2013) Read More / View Supplemental Materials
Abstract
Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1.Tu, D., Zhu Z., Zhou AY, Yun CH, Lee KE, Toms AV, Li Y., Dunn GP, Chan E., Thai T., Yang S., Ficarro SB, Marto JA, Jeon H., Hahn WC, Barbie DA, and Eck MJ Cell reports, 2013/03/28, Volume 3, Issue 3, p.747-58, (2013) Read More / View Supplemental Materials
Abstract
Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death.Adams, DJ, Boskovic ZV, Theriault JR, Wang AJ, Stern AM, Wagner BK, Shamji AF, and Schreiber SL ACS chemical biology, 2013/03/25, (2013) Read More / View Supplemental Materials
Abstract
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.Germain, AR, Carmody LC, Nag PP, Morgan B., VerPlank L., Fernandez C., Donckele E., Feng Y., Perez JR, Dandapani S., Palmer M., Lander E. S., Gupta PB, Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2013/03/15, Volume 23, Issue 6, p.1834-8, (2013) Read More / View Supplemental Materials
Abstract
Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging.Rhee, HW, Zou P., Udeshi ND, Martell JD, Mootha VK, Carr SA, and Ting AY Science (New York, N.Y.), 2013/03/15, Volume 339, Issue 6125, p.1328-31, (2013) Read More / View Supplemental Materials
Abstract
Selective access to trisubstituted macrocyclic e- and z-alkenes from the ring-closing metathesis of vinylsiloxanes.Wang, Y., Jimenez M., Sheehan P., Zhong C., Hung AW, Tam CP, and Young DW Organic letters, 2013/03/15, Volume 15, Issue 6, p.1218-21, (2013) Read More / View Supplemental Materials
Abstract
Estimating selection on synonymous codon usage from noisy experimental data.Wallace, EW, Airoldi EM, and Drummond DA Molecular biology and evolution, 2013/03/14, (2013) Read More / View Supplemental Materials
Abstract
Nozzle: a report generation toolkit for data analysis pipelines.Gehlenborg, N., Noble MS, Getz G., Chin L., and Park PJ Bioinformatics (Oxford, England), 2013/03/11, (2013) Read More / View Supplemental Materials
Abstract
Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis.Sankaran, VG, and Orkin SH Current opinion in genetics & development, 2013/03/07, (2013) Read More / View Supplemental Materials
Abstract
An Inflammatory Situation: SOX2 and STAT3 Cooperate in Squamous Cell Carcinoma Initiation.Bass, AJ, and Wang TC Cell stem cell, 2013/03/07, Volume 12, Issue 3, p.266-8, (2013) Read More / View Supplemental Materials
Abstract
Dynamic regulatory network controlling TH17 cell differentiation.Yosef, N., Shalek AK, Gaublomme JT, Jin H., Lee Y., Awasthi A., Wu C., Karwacz K., Xiao S., Jorgolli M., Gennert D., Satija R., Shakya A., Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M., Tantin D., et al. Nature, 2013/03/06, (2013) Read More / View Supplemental Materials
Abstract
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.Wu, C., Yosef N., Thalhamer T., Zhu C., Xiao S., Kishi Y., Regev A., and Kuchroo VK Nature, 2013/03/06, (2013) Read More / View Supplemental Materials
Abstract
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.Kleinewietfeld, M., Manzel A., Titze J., Kvakan H., Yosef N., Linker RA, Muller DN, and Hafler DA Nature, 2013/03/06, (2013) Read More / View Supplemental Materials
Abstract
Effector-triggered versus pattern-triggered immunity: how animals sense pathogens.Stuart, LM, Paquette N., and Boyer L. Nature reviews. Immunology, 2013/03/01, Volume 13, Issue 3, p.199-206, (2013) Read More / View Supplemental Materials
Abstract
Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing.Kirby, A., Gnirke A., Jaffe DB, Barešová V., Pochet N., Blumenstiel B., Ye C., Aird D., Stevens C., Robinson JT, Cabili MN, Gat-Viks I., Kelliher E., Daza R., DeFelice M., Hůlková H., Sovová J., Vylet'al P., Antignac C., Guttman M., et al. Nature genetics, 2013/03/01, Volume 45, Issue 3, p.299-303, (2013) Read More / View Supplemental Materials
Abstract
Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition.Puissant, A., Frumm SM, Alexe G., Bassil CF, Qi J., Chanthery YH, Nekritz EA, Zeid R., Gustafson WC, Greninger P., Garnett MJ, McDermott U., Benes CH, Kung AL, Weiss WA, Bradner JE, and Stegmaier K. Cancer discovery, 2013/03/01, Volume 3, Issue 3, p.308-323, (2013) Read More / View Supplemental Materials
Abstract
Identification of Nonvisual Photomotor Response Cells in the Vertebrate Hindbrain.Kokel, D., Dunn TW, Ahrens MB, Alshut R., Cheung CY, Saint-Amant L., Bruni G., Mateus R., van Ham TJ, Shiraki T., Fukada Y., Kojima D., Yeh JR, Mikut R., von Lintig J., Engert F., and Peterson RT The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013/02/27, Volume 33, Issue 9, p.3834-3843, (2013) Read More / View Supplemental Materials
Abstract
Using population admixture to help complete maps of the human genome.Genovese, G., Handsaker RE, Li H., Altemose N., Lindgren AM, Chambert K., Pasaniuc B., Price AL, Reich D., Morton CC, Pollak MR, Wilson JG, and McCarroll SA Nature genetics, 2013/02/24, (2013) Read More / View Supplemental Materials
Abstract
Conservation and divergence in the transcriptional programs of the human and mouse immune systems.Shay, T., Jojic V., Zuk O., Rothamel K., Puyraimond-Zemmour D., Feng T., Wakamatsu E., Benoist C., Koller D., Regev A., and ImmGen Consortium Proceedings of the National Academy of Sciences of the United States of America, 2013/02/19, Volume 110, Issue 8, p.2946-51, (2013) Read More / View Supplemental Materials
Abstract
Lack of interaction of beta-cell-function-associated variants with hypertension on change in fasting glucose and diabetes risk: the Framingham Offspring Study.de Miguel-Yanes, JM, Porneala B., Pencina MJ, Fox CS, Florez JC, Siscovick DS, Dupuis J., and Meigs JB Journal of hypertension, 2013/02/19, (2013) Read More / View Supplemental Materials
Abstract
Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif.Wagner, FF, Olson DE, Gale JP, Kaya T., Weïwer M., Aidoud N., Thomas M., Davoine EL, Lemercier BC, Zhang YL, and Holson EB Journal of medicinal chemistry, 2013/02/18, (2013) Read More / View Supplemental Materials
Abstract
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia.Landau, DA, Carter SL, Stojanov P., McKenna A., Stevenson K., Lawrence MS, Sougnez C., Stewart C., Sivachenko A., Wang L., Wan Y., Zhang W., Shukla SA, Vartanov A., Fernandes SM, Saksena G., Cibulskis K., Tesar B., Gabriel S., Hacohen N., et al. Cell, 2013/02/14, Volume 152, Issue 4, p.714-26, (2013) Read More / View Supplemental Materials
Abstract
Identifying recent adaptations in large-scale genomic data.Grossman, SR, Andersen KG, Shlyakhter I., Tabrizi S., Winnicki S., Yen A., Park DJ, Griesemer D., Karlsson EK, Wong SH, Cabili M., Adegbola RA, Bamezai RN, Hill AV, Vannberg FO, Rinn JL, 1000 Genomes Project, Lander E. S., Schaffner SF, and Sabeti PC Cell, 2013/02/14, Volume 152, Issue 4, p.703-13, (2013) Read More / View Supplemental Materials
Abstract
Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant.Kamberov, YG, Wang S., Tan J., Gerbault P., Wark A., Tan L., Yang Y., Li S., Tang K., Chen H., Powell A., Itan Y., Fuller D., Lohmueller J., Mao J., Schachar A., Paymer M., Hostetter E., Byrne E., Burnett M., et al. Cell, 2013/02/14, Volume 152, Issue 4, p.691-702, (2013) Read More / View Supplemental Materials
Abstract
APOL1 variants and kidney disease in people of recent African ancestry.Genovese, G., Friedman DJ, and Pollak MR Nature reviews. Nephrology, 2013/02/12, Volume 9, Issue 4, p.240-4, (2013) Read More / View Supplemental Materials
Abstract
DNA methylation: roles in mammalian development.Smith, ZD, and Meissner A. Nature reviews. Genetics, 2013/02/12, Volume 14, Issue 3, p.204-20, (2013) Read More / View Supplemental Materials
Abstract
Photochemical activation of TRPA1 channels in neurons and animals.Kokel, D., Cheung CY, Mills R., Coutinho-Budd J., Huang L., Setola V., Sprague J., Jin S., Jin YN, Huang XP, Bruni G., Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, and Peterson RT Nature chemical biology, 2013/02/10, (2013) Read More / View Supplemental Materials
Abstract
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples.Cibulskis, K., Lawrence MS, Carter SL, Sivachenko A., Jaffe D., Sougnez C., Gabriel S., Meyerson M., Lander E. S., and Getz G. Nature biotechnology, 2013/02/10, (2013) Read More / View Supplemental Materials
Abstract
The simplest explanation: passive DNA demethylation in PGCs.Smith, ZD, and Meissner A. The EMBO journal, 2013/02/06, Volume 32, Issue 3, p.318-21, (2013) Read More / View Supplemental Materials
Chromatin marks identify critical cell types for fine mapping complex trait variants.Trynka, G., Sandor C., Han B., Xu H., Stranger BE, Liu XS, and Raychaudhuri S. Nature genetics, 2013/02/01, Volume 45, Issue 2, p.124-30, (2013) Read More / View Supplemental Materials
Abstract
Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency.Kiezun, A., Pulit SL, Francioli LC, van Dijk F., Swertz M., Boomsma DI, van Duijn CM, Slagboom PE, van Ommen GJ, Wijmenga C., Genome of the Netherlands Consortium, de Bakker PI, and Sunyaev SR PLoS genetics, 2013/02/01, Volume 9, Issue 2, p.e1003301, (2013) Read More / View Supplemental Materials
Abstract
Fine-scale mapping of the nasonia genome to chromosomes using a high-density genotyping microarray.Desjardins, CA, Gadau J., Lopez JA, Niehuis O., Avery AR, Loehlin DW, Richards S., Colbourne JK, and Werren JH G3 (Bethesda, Md.), 2013/02/01, Volume 3, Issue 2, p.205-15, (2013) Read More / View Supplemental Materials
Abstract
Histone acetylation: molecular mnemonics on the chromatin.Gräff, J., and Tsai LH Nature reviews. Neuroscience, 2013/02/01, Volume 14, Issue 2, p.97-111, (2013) Read More / View Supplemental Materials
Abstract
Large-scale metagenomic sequence clustering on map-reduce clusters.Yang, X., Zola J., and Aluru S. Journal of bioinformatics and computational biology, 2013/02/01, Volume 11, Issue 1, p.1340001, (2013) Read More / View Supplemental Materials
Abstract
Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.Chmielecki, J., Crago AM, Rosenberg M., O'Connor R., Walker SR, Ambrogio L., Auclair D., McKenna A., Heinrich MC, Frank DA, and Meyerson M. Nature genetics, 2013/02/01, Volume 45, Issue 2, p.131-2, (2013) Read More / View Supplemental Materials
Abstract
Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues.Zhu, J., Adli M., Zou JY, Verstappen G., Coyne M., Zhang X., Durham T., Miri M., Deshpande V., De Jager PL, Bennett DA, Houmard JA, Muoio DM, Onder TT, Camahort R., Cowan CA, Meissner A., Epstein CB, Shoresh N., and Bernstein BE Cell, 2013/01/31, Volume 152, Issue 3, p.642-54, (2013) Read More / View Supplemental Materials
Abstract
Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci.Li, Q., Seo JH, Stranger B., McKenna A., Pe'er I., LaFramboise T., Brown M., Tyekucheva S., and Freedman ML Cell, 2013/01/31, Volume 152, Issue 3, p.633-41, (2013) Read More / View Supplemental Materials
Abstract
Epigenetic mechanisms in mood disorders: Targeting neuroplasticity.Fass, DM, Schroeder FA, Perlis RH, and Haggarty SJ Neuroscience, 2013/01/30, (2013) Read More / View Supplemental Materials
Abstract
Eukaryotic virulence determinants utilize phosphoinositides at the ER and host cell surface.Jiang, RH, Stahelin RV, Bhattacharjee S., and Haldar K. Trends in microbiology, 2013/01/29, (2013) Read More / View Supplemental Materials
Abstract
Human systems immunology: Hypothesis-based modeling and unbiased data-driven approaches.Arazi, A., Pendergraft WF 3rd, Ribeiro RM, Perelson AS, and Hacohen N. Seminars in immunology, 2013/01/29, (2013) Read More / View Supplemental Materials
Abstract
Highly Recurrent TERT Promoter Mutations in Human Melanoma.Huang, FW, Hodis E., Xu MJ, Kryukov GV, Chin L., and Garraway LA Science (New York, N.Y.), 2013/01/24, (2013) Read More / View Supplemental Materials
Abstract
Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders.Lim, ET, Raychaudhuri S., Sanders SJ, Stevens C., Sabo A., Macarthur DG, Neale BM, Kirby A., Ruderfer DM, Fromer M., Lek M., Liu L., Flannick J., Ripke S., Nagaswamy U., Muzny D., Reid JG, Hawes A., Newsham I., Wu Y., et al. Neuron, 2013/01/23, Volume 77, Issue 2, p.235-42, (2013) Read More / View Supplemental Materials
Abstract
Using Whole-Exome Sequencing to Identify Inherited Causes of Autism.Yu, TW, Chahrour MH, Coulter ME, Jiralerspong S., Okamura-Ikeda K., Ataman B., Schmitz-Abe K., Harmin DA, Adli M., Malik AN, D'Gama AM, Lim ET, Sanders SJ, Mochida GH, Partlow JN, Sunu CM, Felie JM, Rodriguez J., Nasir RH, Ware J., et al. Neuron, 2013/01/23, Volume 77, Issue 2, p.259-273, (2013) Read More / View Supplemental Materials
Abstract
Ultranet: efficient solver for the sparse inverse covariance selection problem in gene network modeling.Järvstråt, L., Johansson M., Gullberg U., and Nilsson B. Bioinformatics (Oxford, England), 2013/01/21, (2013) Read More / View Supplemental Materials
Abstract
The genetic landscape of high-risk neuroblastoma.Pugh, TJ, Morozova O., Attiyeh EF, Asgharzadeh S., Wei JS, Auclair D., Carter SL, Cibulskis K., Hanna M., Kiezun A., Kim J., Lawrence MS, McKenna A., Pedamallu CS, Ramos AH, Shefler E., Sivachenko A., Sougnez C., Stewart C., Ally A., et al. Nature genetics, 2013/01/20, (2013) Read More / View Supplemental Materials
Abstract
Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.Brastianos, PK, Horowitz PM, Santagata S., Jones RT, McKenna A., Getz G., Ligon KL, Palescandolo E., Van Hummelen P., Ducar MD, Raza A., Macconaill LE, Louis DN, Hahn WC, Dunn IF, and Beroukhim R. Nature genetics, 2013/01/20, (2013) Read More / View Supplemental Materials
Abstract
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. viral proteinase slides along DNA to locate and process its substrates.Blainey, PC, Graziano V., Pérez-Berná AJ, McGrath WJ, Flint SJ, San Martín C., Xie XS, and Mangel WF The Journal of biological chemistry, 2013/01/18, Volume 288, Issue 3, p.2092-102, (2013) Read More / View Supplemental Materials
Abstract
ATG5 regulates plasma cell differentiation.Conway, KL, Kuballa P., Khor B., Zhang M., Shi HN, Virgin HW, and Xavier RJ Autophagy, 2013/01/17, Volume 9, Issue 4, (2013) Read More / View Supplemental Materials
Abstract
Prognostic Gene-Expression Signature for Patients with Hepatitis C-Related Early-Stage Cirrhosis.Hoshida, Y., Villanueva A., Sangiovanni A., Sole M., Hur C., Andersson KL, Chung RT, Gould J., Kojima K., Gupta S., Taylor B., Crenshaw A., Gabriel S., Minguez B., Iavarone M., Friedman SL, Colombo M., Llovet JM, and Golub T. R. Gastroenterology, 2013/01/17, (2013) Read More / View Supplemental Materials
Abstract
Mosaic copy number variation in schizophrenia.Ruderfer, DM, Chambert K., Moran J., Talkowski M., Chen ES, Gigek C., Gusella JF, Blackwood DH, Corvin A., Gurling HM, Hultman CM, Kirov G., Magnusson P., O'Donovan MC, Owen MJ, Pato C., St Clair D., Sullivan PF, Purcell SM, Sklar P., et al. European journal of human genetics : EJHG, 2013/01/16, (2013) Read More / View Supplemental Materials
Abstract
Rare, Low-Frequency, and Common Variants in the Protein-Coding Sequence of Biological Candidate Genes from GWASs Contribute to Risk of Rheumatoid Arthritis.Diogo, D., Kurreeman F., Stahl EA, Liao KP, Gupta N., Greenberg JD, Rivas MA, Hickey B., Flannick J., Thomson B., Guiducci C., Ripke S., Adzhubey I., Barton A., Kremer JM, Alfredsson L., Consortium of Rheumatology Researchers of North America, Rheumatoid Arthritis Consortium International, Sunyaev S., Martin J., et al. American journal of human genetics, 2013/01/10, Volume 92, Issue 1, p.15-27, (2013) Read More / View Supplemental Materials
Abstract
Complementary RNA and Protein Profiling Identifies Iron as a Key Regulator of Mitochondrial Biogenesis.Rensvold, JW, Ong SE, Jeevananthan A., Carr SA, Mootha VK, and Pagliarini DJ Cell reports, 2013/01/09, (2013) Read More / View Supplemental Materials
Abstract
Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation.Costello, M., Pugh TJ, Fennell TJ, Stewart C., Lichtenstein L., Meldrim JC, Fostel JL, Friedrich DC, Perrin D., Dionne D., Kim S., Gabriel SB, Lander E. S., Fisher S., and Getz G. Nucleic acids research, 2013/01/08, (2013) Read More / View Supplemental Materials
Abstract
The future is now: single-cell genomics of bacteria and archaea.Blainey, PC FEMS microbiology reviews, 2013/01/08, (2013) Read More / View Supplemental Materials
Abstract
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.Whittaker, SR, Theurillat JP, Van Allen E., Wagle N., Hsiao J., Cowley GS, Schadendorf D., Root DE, and Garraway LA Cancer discovery, 2013/01/03, (2013) Read More / View Supplemental Materials
Abstract
Multiplex Genome Engineering Using CRISPR/Cas Systems.Cong, L., Ran FA, Cox D., Lin S., Barretto R., Habib N., Hsu PD, Wu X., Jiang W., Marraffini LA, and Zhang F. Science (New York, N.Y.), 2013/01/03, (2013) Read More / View Supplemental Materials
Abstract
AUTOMATED QUANTIFICATION OF ZEBRAFISH TAIL DEFORMATION FOR HIGH-THROUGHPUT DRUG SCREENING.Ishaq, O., Negri J., Bray MA, Pacureanu A., Peterson RT, and Wählby C. Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging, 2013/01/01, p.902-905, (2013) Read More / View Supplemental Materials
Abstract
Computational prediction of lysine acetylation proteome-wide.Basu, A. Methods in molecular biology (Clifton, N.J.), 2013/01/01, Volume 981, p.127-36, (2013) Read More / View Supplemental Materials
Abstract
Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.Wang, C., Eessalu TE, Barth VN, Mitch CH, Wagner FF, Hong Y., Neelamegam R., Schroeder FA, Holson EB, Haggarty SJ, and Hooker JM American journal of nuclear medicine and molecular imaging, 2013/01/01, Volume 4, Issue 1, p.29-38, (2013) Read More / View Supplemental Materials
Abstract
Evolutionary principles of modular gene regulation in yeasts.Thompson, DA, Roy S., Chan M., Styczynsky MP, Pfiffner J., French C., Socha A., Thielke A., Napolitano S., Muller P., Kellis M., Konieczka JH, Wapinski I., and Regev A. eLife, 2013/01/01, Volume 2, p.e00603, (2013) Read More / View Supplemental Materials
Abstract
Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal.Daniels, R., Chang HH, Séne PD, Park DC, Neafsey DE, Schaffner SF, Hamilton EJ, Lukens AK, Van Tyne D., Mboup S., Sabeti PC, Ndiaye D., Wirth DF, Hartl DL, and Volkman SK PloS one, 2013/01/01, Volume 8, Issue 4, p.e60780, (2013) Read More / View Supplemental Materials
Abstract
Identification of Trypanosome proteins in plasma from African sleeping sickness patients infected with T. b. rhodesiense.Eyford, BA, Ahmad R., Enyaru JC, Carr SA, and Pearson TW PloS one, 2013/01/01, Volume 8, Issue 8, p.e71463, (2013) Read More / View Supplemental Materials
Abstract
Magnetic barcode assay for genetic detection of pathogens.Liong, M., Hoang AN, Chung J., Gural N., Ford CB, Min C., Shah RR, Ahmad R., Fernandez-Suarez M., Fortune SM, Toner M., Lee H., and Weissleder R. Nature communications, 2013/01/01, Volume 4, p.1752, (2013) Read More / View Supplemental Materials
Abstract
MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling.Plovanich, M., Bogorad RL, Sancak Y., Kamer KJ, Strittmatter L., Li AA, Girgis HS, Kuchimanchi S., De Groot J., Speciner L., Taneja N., Oshea J., Koteliansky V., and Mootha VK PloS one, 2013/01/01, Volume 8, Issue 2, p.e55785, (2013) Read More / View Supplemental Materials
Abstract
ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans.Youngsaye, W., Hartland CL, Morgan BJ, Ting A., Nag PP, Vincent B., Mosher CA, Bittker JA, Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. Beilstein journal of organic chemistry, 2013/01/01, Volume 9, p.1501-7, (2013) Read More / View Supplemental Materials
Abstract
Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry.Gillette, MA, and Carr SA Nature methods, 2013/01/01, Volume 10, Issue 1, p.28-34, (2013) Read More / View Supplemental Materials
Abstract
Reconstructing roma history from genome-wide data.Moorjani, P., Patterson N., Loh PR, Lipson M., Kisfali P., Melegh BI, Bonin M., Kádaši L., Rieß O., Berger B., Reich D., and Melegh B. PloS one, 2013/01/01, Volume 8, Issue 3, p.e58633, (2013) Read More / View Supplemental Materials
Abstract
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.Schroeder, FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J., Zhao WN, Reis S., Barker DD, Berry-Scott E., Kim SW, Clore EL, Hooker JM, Holson EB, Haggarty SJ, and Petryshen TL PloS one, 2013/01/01, Volume 8, Issue 8, p.e71323, (2013) Read More / View Supplemental Materials
Abstract
‘Big data’ from shrinking pathogen populations.Neafsey, DE Molecular ecology, 2013/01/01, Volume 22, Issue 2, p.271-2, (2013) Read More / View Supplemental Materials
Abstract
2012
How deep is deep enough for RNA-Seq profiling of bacterial transcriptomes?Haas, BJ, Chin M., Nusbaum C., Birren BW, and Livny J. BMC genomics, 2012/12/27, Volume 13, p.734, (2012) Read More / View Supplemental Materials
Abstract
ATARiS: Computational quantification of gene suppression phenotypes from multi-sample RNAi screens.Shao, DD, Tsherniak A., Gopal S., Weir BA, Tamayo P., Stransky N., Schumacher SE, Zack TI, Beroukhim R., Garraway LA, Margolin AA, Root DE, Hahn WC, and Mesirov J. P. Genome research, 2012/12/26, (2012) Read More / View Supplemental Materials
Abstract
Refined Preparation and Use of Anti-K- epsilon -GG Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments.Udeshi, ND, Svinkina T., Mertins P., Kuhn E., Mani D. R., Qiao JW, and Carr SA Molecular & cellular proteomics : MCP, 2012/12/24, (2012) Read More / View Supplemental Materials
Abstract
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.Lee, MN, Roy M., Ong SE, Mertins P., Villani AC, Li W., Dotiwala F., Sen J., Doench JG, Orzalli MH, Kramnik I., Knipe DM, Lieberman J., Carr SA, and Hacohen N. Nature immunology, 2012/12/23, Volume 14, Issue 2, p.179-85, (2012) Read More / View Supplemental Materials
Abstract
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.Efeyan, A., Zoncu R., Chang S., Gumper I., Snitkin H., Wolfson RL, Kirak O., Sabatini DD, and Sabatini DM Nature, 2012/12/23, (2012) Read More / View Supplemental Materials
Abstract
β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis.Rosenbluh, J., Nijhawan D., Cox AG, Li X., Schafer EJ, Zack TI, Wang X., Tsherniak A., Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F., Cowley GS, Root DE, Mesirov J. P., Beroukhim R., and Hahn WC Cell, 2012/12/21, Volume 151, Issue 7, p.1457-73, (2012) Read More / View Supplemental Materials
Abstract
The nature of confounding in genome-wide association studies.Vilhjálmsson, BJ, and Nordborg M. Nature reviews. Genetics, 2012/12/18, Volume 14, Issue 1, p.1-2, (2012) Read More / View Supplemental Materials
Abstract
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.Birsoy, K., Wang T., Possemato R., Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y., Peterson TR, Carette JE, Brummelkamp TR, Clish CB, and Sabatini DM Nature genetics, 2012/12/16, Volume 45, Issue 1, p.104-8, (2012) Read More / View Supplemental Materials
Abstract
Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.Barretina, J., Caponigro G., Stransky N., Venkatesan K., Margolin AA, Kim S., Wilson CJ, Lehár J., Kryukov GV, Sonkin D., Reddy A., Liu M., Murray L., Berger MF, Monahan JE, Morais P., Meltzer J., Korejwa A., Jané-Valbuena J., Mapa FA, et al. Nature, 2012/12/13, Volume 492, Issue 7428, p.290, (2012) Read More / View Supplemental Materials
The LRR and RING Domain Protein LRSAM1 Is an E3 Ligase Crucial for Ubiquitin-Dependent Autophagy of Intracellular Salmonella Typhimurium.Huett, A., Heath RJ, Begun J., Sassi SO, Baxt LA, Vyas JM, Goldberg MB, and Xavier RJ Cell host & microbe, 2012/12/13, Volume 12, Issue 6, p.778-90, (2012) Read More / View Supplemental Materials
Abstract
A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.Weïwer, M., Spoonamore J., Wei J., Guichard B., Ross NT, Masson K., Silkworth W., Dandapani S., Palmer M., Scherer CA, Stern AM, Schreiber SL, and Munoz B. ACS medicinal chemistry letters, 2012/12/13, Volume 3, Issue 12, p.1034-1038, (2012) Read More / View Supplemental Materials
Abstract
The ANK3 Bipolar Disorder Gene Regulates Psychiatric-Related Behaviors That Are Modulated by Lithium and Stress.Leussis, MP, Berry-Scott EM, Saito M., Jhuang H., De Haan G., Alkan O., Luce CJ, Madison JM, Sklar P., Serre T., Root DE, and Petryshen TL Biological psychiatry, 2012/12/10, (2012) Read More / View Supplemental Materials
Abstract
Differential analysis of gene regulation at transcript resolution with RNA-seq.Trapnell, C., Hendrickson DG, Sauvageau M., Goff L., Rinn JL, and Pachter L. Nature biotechnology, 2012/12/09, Volume 31, Issue 1, p.46-53, (2012) Read More / View Supplemental Materials
Abstract
Cellular alchemy and the golden age of reprogramming.Daley, GQ Cell, 2012/12/07, Volume 151, Issue 6, p.1151-4, (2012) Read More / View Supplemental Materials
Abstract
Differential relationship of DNA replication timing to different forms of human mutation and variation.Koren, A., Polak P., Nemesh J., Michaelson JJ, Sebat J., Sunyaev SR, and McCarroll SA American journal of human genetics, 2012/12/07, Volume 91, Issue 6, p.1033-40, (2012) Read More / View Supplemental Materials
Abstract
Disruption of a large intergenic noncoding RNA in subjects with neurodevelopmental disabilities.Talkowski, ME, Maussion G., Crapper L., Rosenfeld JA, Blumenthal I., Hanscom C., Chiang C., Lindgren A., Pereira S., Ruderfer D., Diallo AB, Lopez JP, Turecki G., Chen ES, Gigek C., Harris DJ, Lip V., An Y., Biagioli M., Macdonald ME, et al. American journal of human genetics, 2012/12/07, Volume 91, Issue 6, p.1128-34, (2012) Read More / View Supplemental Materials
Abstract
Integrative annotation of chromatin elements from ENCODE data.Hoffman, MM, Ernst J., Wilder SP, Kundaje A., Harris RS, Libbrecht M., Giardine B., Ellenbogen PM, Bilmes JA, Birney E., Hardison RC, Dunham I., Kellis M., and Noble WS Nucleic acids research, 2012/12/05, (2012) Read More / View Supplemental Materials
Abstract
Hits, leads and drugs against malaria through diversity-oriented synthesis.Dandapani, S., Comer E., Duvall JR, and Munoz B. Future medicinal chemistry, 2012/12/01, Volume 4, Issue 18, p.2279-94, (2012) Read More / View Supplemental Materials
Abstract
Targeted therapy for squamous cell lung cancer.Liao, RG, Watanabe H., Meyerson M., and Hammerman PS Lung cancer management, 2012/12/01, Volume 1, Issue 4, p.293-300, (2012) Read More / View Supplemental Materials
Abstract
Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset.Pasternak, O., Westin CF, Bouix S., Seidman LJ, Goldstein JM, Woo TU, Petryshen TL, Mesholam-Gately RI, McCarley RW, Kikinis R., Shenton ME, and Kubicki M. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012/11/28, Volume 32, Issue 48, p.17365-17372, (2012) Read More / View Supplemental Materials
Abstract
Microcephaly Gene Links Trithorax and REST/NRSF to Control Neural Stem Cell Proliferation and Differentiation.Yang, YJ, Baltus AE, Mathew RS, Murphy EA, Evrony GD, Gonzalez DM, Wang EP, Marshall-Walker CA, Barry BJ, Murn J., Tatarakis A., Mahajan MA, Samuels HH, Shi Y., Golden JA, Mahajnah M., Shenhav R., and Walsh CA Cell, 2012/11/21, Volume 151, Issue 5, p.1097-1112, (2012) Read More / View Supplemental Materials
Abstract
The Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans.Smith, JG, Avery CL, Evans DS, Nalls MA, Meng YA, Smith EN, Palmer C., Tanaka T., Mehra R., Butler AM, Young T., Buxbaum SG, Kerr KF, Berenson GS, Schnabel RB, Li G., Ellinor PT, Magnani JW, Chen W., Bis JC, et al. Circulation. Cardiovascular genetics, 2012/11/19, (2012) Read More / View Supplemental Materials
Abstract
From genetic discovery to future personalized health research.Palotie, A., Widén E., and Ripatti S. New biotechnology, 2012/11/16, (2012) Read More / View Supplemental Materials
Abstract
Expression Profiling of Archival Tumors for Long-term Health Studies.Waldron, L., Ogino S., Hoshida Y., Shima K., McCart Reed AE, Simpson PT, Baba Y., Nosho K., Segata N., Vargas AC, Cummings MC, Lakhani SR, Kirkner GJ, Giovannucci E., Quackenbush J., Golub T. R., Fuchs CS, Parmigiani G., and Huttenhower C. Clinical cancer research : an official journal of the American Association for Cancer Research, 2012/11/15, Volume 18, Issue 22, p.6136-6146, (2012) Read More / View Supplemental Materials
Abstract
Risk of Intracranial Hemorrhage With Protease-Activated Receptor-1 Antagonists.Falcone, GJ, Brouwers HB, and Rosand J. Stroke; a journal of cerebral circulation, 2012/11/15, (2012) Read More / View Supplemental Materials
Mitochondrial disorders as windows into an ancient organelle.Vafai, SB, and Mootha VK Nature, 2012/11/14, Volume 491, Issue 7424, p.374-383, (2012) Read More / View Supplemental Materials
Abstract
Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder.Lee, PH, Perlis RH, Jung JY, Byrne EM, Rueckert E., Siburian R., Haddad S., Mayerfeld CE, Heath AC, Pergadia ML, Madden PA, Boomsma DI, Penninx BW, Sklar P., Martin NG, Wray NR, Purcell SM, and Smoller JW Translational psychiatry, 2012/11/13, Volume 2, p.e184, (2012) Read More / View Supplemental Materials
Abstract
Will cholesteryl ester transfer protein inhibition succeed primarily by lowering low-density lipoprotein cholesterol?: insights from human genetics and clinical trials.Kathiresan, S. Journal of the American College of Cardiology, 2012/11/13, Volume 60, Issue 20, p.2049-52, (2012) Read More / View Supplemental Materials
Epidemiology. Emerging disease or diagnosis?Gire, SK, Stremlau M., Andersen KG, Schaffner SF, Bjornson Z., Rubins K., Hensley L., McCormick JB, Lander E. S., Garry RF, Happi C., and Sabeti PC Science (New York, N.Y.), 2012/11/09, Volume 338, Issue 6108, p.750-2, (2012) Read More / View Supplemental Materials