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2011
Molecular signatures database (MSigDB) 3.0.Liberzon, A., Subramanian A., Pinchback R., Thorvaldsdóttir H., Tamayo P., and Mesirov J. P. Bioinformatics (Oxford, England), 2011/06/15, Volume 27, Issue 12, p.1739-40, (2011) Read More / View Supplemental Materials
Abstract
mRNA expression signature of Gleason grade predicts lethal prostate cancer.Penney, KL, Sinnott JA, Fall K., Pawitan Y., Hoshida Y., Kraft P., Stark JR, Fiorentino M., Perner S., Finn S., Calza S., Flavin R., Freedman ML, Setlur S., Sesso HD, Andersson SO, Martin N., Kantoff PW, Johansson JE, Adami HO, et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/06/10, Volume 29, Issue 17, p.2391-6, (2011) Read More / View Supplemental Materials
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Syntheses of α-pyrones using gold-catalyzed coupling reactions.Luo, T., Dai M., Zheng SL, and Schreiber SL Organic letters, 2011/06/03, Volume 13, Issue 11, p.2834-6, (2011) Read More / View Supplemental Materials
Abstract
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.Pan, JQ, Lewis MC, Ketterman JK, Clore EL, Riley M., Richards KR, Berry-Scott E., Liu X., Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, and Haggarty SJ Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011/06/01, Volume 36, Issue 7, p.1397-411, (2011) Read More / View Supplemental Materials
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Computational methods for transcriptome annotation and quantification using RNA-seq.Garber, M., Grabherr MG, Guttman M., and Trapnell C. Nature methods, 2011/06/01, Volume 8, Issue 6, p.469-77, (2011) Read More / View Supplemental Materials
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Endemic dengue associated with the co-circulation of multiple viral lineages and localized density-dependent transmission.Raghwani, J., Rambaut A., Holmes EC, Hang VT, Hien TT, Farrar J., Wills B., Lennon NJ, Birren BW, Henn MR, and Simmons CP PLoS pathogens, 2011/06/01, Volume 7, Issue 6, p.e1002064, (2011) Read More / View Supplemental Materials
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RNA-protein interactions in human health and disease.Khalil, AM, and Rinn JL Seminars in cell & developmental biology, 2011/06/01, Volume 22, Issue 4, p.359-65, (2011) Read More / View Supplemental Materials
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Summaries from the XVIII World Congress of Psychiatric Genetics, Athens, Greece, 3-7 October 2010.Bergen, SE, Balhara YP, Christoforou A., Cole J., Degenhardt F., Dempster E., Fatjó-Vilas M., Khedr Y., Lopez LM, Lysenko L., McGrath LM, Mühleisen TW, Neves FS, Nymberg C., Ozomaro U., Verweij KJ, Voineskos AN, Zai CC, O'Shea A., and DeLisi LE Psychiatric genetics, 2011/06/01, Volume 21, Issue 3, p.136-72, (2011) Read More / View Supplemental Materials
Abstract
Obligate biotrophy features unraveled by the genomic analysis of rust fungi.Duplessis, S., Cuomo CA, Lin YC, Aerts A., Tisserant E., Veneault-Fourrey C., Joly DL, Hacquard S., Amselem J., Cantarel BL, Chiu R., Coutinho PM, Feau N., Field M., Frey P., Gelhaye E., Goldberg J., Grabherr MG, Kodira CD, Kohler A., et al. Proceedings of the National Academy of Sciences of the United States of America, 2011/05/31, Volume 108, Issue 22, p.9166-71, (2011) Read More / View Supplemental Materials
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Full-length transcriptome assembly from RNA-Seq data without a reference genome.Grabherr, MG, Haas BJ, Yassour M., Levin JZ, Thompson DA, Amit I., Adiconis X., Fan L., Raychowdhury R., Zeng Q., Chen Z., Mauceli E., Hacohen N., Gnirke A., Rhind N., Di Palma F., Birren BW, Nusbaum C., Lindblad-Toh K., Friedman N., et al. Nature biotechnology, 2011/05/15, Volume 29, Issue 7, p.644-52, (2011) Read More / View Supplemental Materials
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Mapping and analysis of chromatin state dynamics in nine human cell types.Ernst, J., Kheradpour P., Mikkelsen TS, Shoresh N., Ward LD, Epstein CB, Zhang X., Wang L., Issner R., Coyne M., Ku M., Durham T., Kellis M., and Bernstein BE Nature, 2011/05/05, Volume 473, Issue 7345, p.43-9, (2011) Read More / View Supplemental Materials
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Discovery of histone deacetylase 8 selective inhibitors.Tang, W., Luo T., Greenberg EF, Bradner JE, and Schreiber SL Bioorganic & medicinal chemistry letters, 2011/05/01, Volume 21, Issue 9, p.2601-5, (2011) Read More / View Supplemental Materials
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Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis.Zella, GC, Hait EJ, Glavan T., Gevers D., Ward DV, Kitts CL, and Korzenik JR Inflammatory bowel diseases, 2011/05/01, Volume 17, Issue 5, p.1092-100, (2011) Read More / View Supplemental Materials
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A framework for variation discovery and genotyping using next-generation DNA sequencing data.DePristo, MA, Banks E., Poplin R., Garimella KV, Maguire JR, Hartl C., Philippakis AA, del Angel G., Rivas MA, Hanna M., McKenna A., Fennell TJ, Kernytsky AM, Sivachenko AY, Cibulskis K., Gabriel SB, Altshuler D., and Daly M. J. Nature genetics, 2011/05/01, Volume 43, Issue 5, p.491-8, (2011) Read More / View Supplemental Materials
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Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells.Rabani, M., Levin JZ, Fan L., Adiconis X., Raychowdhury R., Garber M., Gnirke A., Nusbaum C., Hacohen N., Friedman N., Amit I., and Regev A. Nature biotechnology, 2011/05/01, Volume 29, Issue 5, p.436-42, (2011) Read More / View Supplemental Materials
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Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications.Yilmaz, P., Kottmann R., Field D., Knight R., Cole JR, Amaral-Zettler L., Gilbert JA, Karsch-Mizrachi I., Johnston A., Cochrane G., Vaughan R., Hunter C., Park J., Morrison N., Rocca-Serra P., Sterk P., Arumugam M., Bailey M., Baumgartner L., Birren BW, et al. Nature biotechnology, 2011/05/01, Volume 29, Issue 5, p.415-20, (2011) Read More / View Supplemental Materials
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Points of view: the overview figure.Wong, B. Nature methods, 2011/05/01, Volume 8, Issue 5, p.365, (2011) Read More / View Supplemental Materials
Targeting mutant fibroblast growth factor receptors in cancer.Greulich, H., and Pollock PM Trends in molecular medicine, 2011/05/01, Volume 17, Issue 5, p.283-92, (2011) Read More / View Supplemental Materials
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Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles.Comer, E., Liu H., Joliton A., Clabaut A., Johnson C., Akella LB, and Marcaurelle LA Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6751-6, (2011) Read More / View Supplemental Materials
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Organic synthesis toward small-molecule probes and drugs.Schreiber, SL Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6699-702, (2011) Read More / View Supplemental Materials
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Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.Clemons, PA, Wilson JA, Dančík V., Muller S., Carrinski HA, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6817-22, (2011) Read More / View Supplemental Materials
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Route to three-dimensional fragments using diversity-oriented synthesis.Hung, AW, Ramek A., Wang Y., Kaya T., Wilson JA, Clemons PA, and Young DW Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6799-804, (2011) Read More / View Supplemental Materials
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Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software.Kamentsky, L., Jones TR, Fraser A., Bray MA, Logan DJ, Madden KL, Ljosa V., Rueden C., Eliceiri KW, and Carpenter AE Bioinformatics (Oxford, England), 2011/04/15, Volume 27, Issue 8, p.1179-80, (2011) Read More / View Supplemental Materials
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Improving SNP discovery by base alignment quality.Li, H. Bioinformatics (Oxford, England), 2011/04/15, Volume 27, Issue 8, p.1157-8, (2011) Read More / View Supplemental Materials
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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.Cho, YJ, Tsherniak A., Tamayo P., Santagata S., Ligon A., Greulich H., Berhoukim R., Amani V., Goumnerova L., Eberhart CG, Lau CC, Olson JM, Gilbertson RJ, Gajjar A., Delattre O., Kool M., Ligon K., Meyerson M., Mesirov J. P., and Pomeroy SL Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/04/10, Volume 29, Issue 11, p.1424-30, (2011) Read More / View Supplemental Materials
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Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features.Tamayo, P., Cho YJ, Tsherniak A., Greulich H., Ambrogio L., Schouten-van Meeteren N., Zhou T., Buxton A., Kool M., Meyerson M., Pomeroy SL, and Mesirov J. P. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/04/10, Volume 29, Issue 11, p.1415-23, (2011) Read More / View Supplemental Materials
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Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.Heath, RJ, Leong JM, Visegrády B., Machesky LM, and Xavier RJ PLoS pathogens, 2011/04/01, Volume 7, Issue 4, p.e1001332, (2011) Read More / View Supplemental Materials
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Evaluation of large scale quantitative proteomic assay development using peptide affinity-based mass spectrometry.Whiteaker, JR, Zhao L., Abbatiello SE, Burgess M., Kuhn E., Lin C., Pope ME, Razavi M., Anderson NL, Pearson TW, Carr SA, and Paulovich AG Molecular & cellular proteomics : MCP, 2011/04/01, Volume 10, Issue 4, p.M110.005645, (2011) Read More / View Supplemental Materials
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Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.Van Tyne, D., Park DJ, Schaffner SF, Neafsey DE, Angelino E., Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA Jr, Johnson CA, Shlyakhter I., Grossman SR, Becker JS, Yamins D., Karlsson EK, Ndiaye D., Sarr O., Mboup S., et al. PLoS genetics, 2011/04/01, Volume 7, Issue 4, p.e1001383, (2011) Read More / View Supplemental Materials
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Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.Rhee, EP, Cheng S., Larson MG, Walford GA, Lewis GD, McCabe E., Yang E., Farrell L., Fox CS, O'Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, and Gerszten RE The Journal of clinical investigation, 2011/04/01, Volume 121, Issue 4, p.1402-11, (2011) Read More / View Supplemental Materials
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Metabolite profiles and the risk of developing diabetes.Wang, TJ, Larson MG, Vasan RS, Cheng S., Rhee EP, McCabe E., Lewis GD, Fox CS, Jacques PF, Fernandez C., O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A., Melander O., Clish CB, and Gerszten RE Nature medicine, 2011/04/01, Volume 17, Issue 4, p.448-53, (2011) Read More / View Supplemental Materials
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Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling.Gu, H., Smith ZD, Bock C., Boyle P., Gnirke A., and Meissner A. Nature protocols, 2011/04/01, Volume 6, Issue 4, p.468-81, (2011) Read More / View Supplemental Materials
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Screening: Low-fat worms on drugs.Wagner, BK Nature chemical biology, 2011/04/01, Volume 7, Issue 4, p.194-5, (2011) Read More / View Supplemental Materials
Initial genome sequencing and analysis of multiple myeloma.Chapman, MA, Lawrence MS, Keats JJ, Cibulskis K., Sougnez C., Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M., Anderson KC, Ardlie KG, Auclair D., Baker A., Bergsagel PL, Bernstein BE, Drier Y., Fonseca R., Gabriel SB, Hofmeister CC, et al. Nature, 2011/03/24, Volume 471, Issue 7339, p.467-72, (2011) Read More / View Supplemental Materials
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Impulse control: temporal dynamics in gene transcription.Yosef, N., and Regev A. Cell, 2011/03/18, Volume 144, Issue 6, p.886-96, (2011) Read More / View Supplemental Materials
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Large-scale synthesis of all stereoisomers of a 2,3-unsaturated C-glycoside scaffold.Gerard, B., Marié JC, Pandya BA, Lee MD 4th, Liu H., and Marcaurelle LA The Journal of organic chemistry, 2011/03/18, Volume 76, Issue 6, p.1898-901, (2011) Read More / View Supplemental Materials
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SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.Souza, A., Zhang J., and Clish CB Cancer cell, 2011/03/08, Volume 19, Issue 3, p.416-28, (2011) Read More / View Supplemental Materials
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Chemoproteomics quantifies complexity.Holson, EB, and Schreiber SL Nature biotechnology, 2011/03/01, Volume 29, Issue 3, p.235-6, (2011) Read More / View Supplemental Materials
Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons.Haas, BJ, Gevers D., Earl AM, Feldgarden M., Ward DV, Giannoukos G., Ciulla D., Tabbaa D., Highlander SK, Sodergren E., Methé B., DeSantis TZ, Human Microbiome Consortium, Petrosino JF, Knight R., and Birren BW Genome research, 2011/03/01, Volume 21, Issue 3, p.494-504, (2011) Read More / View Supplemental Materials
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Points of view: Points of review (part 2).Wong, B. Nature methods, 2011/03/01, Volume 8, Issue 3, p.189, (2011) Read More / View Supplemental Materials
Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance.Kang, MS, Lee EK, Soni V., Lewis TA, Koehler AN, Srinivasan V., and Kieff E. Journal of virology, 2011/03/01, Volume 85, Issue 6, p.2859-68, (2011) Read More / View Supplemental Materials
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Tabix: fast retrieval of sequence features from generic TAB-delimited files.Li, H. Bioinformatics (Oxford, England), 2011/03/01, Volume 27, Issue 5, p.718-9, (2011) Read More / View Supplemental Materials
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Genome-sequencing anniversary. The accelerator.Lander, E. S. Science (New York, N.Y.), 2011/02/25, Volume 331, Issue 6020, p.1024, (2011) Read More / View Supplemental Materials
Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.Green, MR, Monti S., Dalla-Favera R., Pasqualucci L., Walsh NC, Schmidt-Supprian M., Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K., Golub T. R., Alt F. W., Shipp M. A., and Manis J. P. Proceedings of the National Academy of Sciences of the United States of America, 2011/02/15, Volume 108, Issue 7, p.2873-8, (2011) Read More / View Supplemental Materials
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Visual representation of scientific information.Wong, B. Science signaling, 2011/02/15, Volume 4, Issue 160, p.pt1, (2011) Read More / View Supplemental Materials
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The genomic complexity of primary human prostate cancer.Berger, MF, Lawrence MS, Demichelis F., Drier Y., Cibulskis K., Sivachenko AY, Sboner A., Esgueva R., Pflueger D., Sougnez C., Onofrio R., Carter SL, Park K., Habegger L., Ambrogio L., Fennell T., Parkin M., Saksena G., Voet D., Ramos AH, et al. Nature, 2011/02/10, Volume 470, Issue 7333, p.214-20, (2011) Read More / View Supplemental Materials
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Initial impact of the sequencing of the human genome.Lander, E. S. Nature, 2011/02/10, Volume 470, Issue 7333, p.187-97, (2011) Read More / View Supplemental Materials
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SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.Ding, Z., Wu CJ, Chu GC, Xiao Y., Ho D., Zhang J., Perry SR, Labrot ES, Wu X., Lis R., Hoshida Y., Hiller D., Hu B., Jiang S., Zheng H., Stegh AH, Scott KL, Signoretti S., Bardeesy N., Wang YA, et al. Nature, 2011/02/10, Volume 470, Issue 7333, p.269-73, (2011) Read More / View Supplemental Materials
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Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate.Proia, TA, Keller PJ, Gupta PB, Klebba I., Jones AD, Sedic M., Gilmore H., Tung N., Naber SP, Schnitt S., Lander E. S., and Kuperwasser C. Cell stem cell, 2011/02/04, Volume 8, Issue 2, p.149-63, (2011) Read More / View Supplemental Materials
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Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.Bock, C., Kiskinis E., Verstappen G., Gu H., Boulting G., Smith ZD, Ziller M., Croft GF, Amoroso MW, Oakley DH, Gnirke A., Eggan K., and Meissner A. Cell, 2011/02/04, Volume 144, Issue 3, p.439-52, (2011) Read More / View Supplemental Materials
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Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.Elkabets, M., Gifford AM, Scheel C., Nilsson B., Reinhardt F., Bray MA, Carpenter AE, Jirström K., Magnusson K., Ebert BL, Pontén F., Weinberg R. A., and McAllister SS The Journal of clinical investigation, 2011/02/01, Volume 121, Issue 2, p.784-99, (2011) Read More / View Supplemental Materials
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Points of review (part 1).Wong, B. Nature methods, 2011/02/01, Volume 8, Issue 2, p.101, (2011) Read More / View Supplemental Materials
Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.Gomez, JE, Clatworthy A., and Hung DT Critical reviews in biochemistry and molecular biology, 2011/02/01, Volume 46, Issue 1, p.41-66, (2011) Read More / View Supplemental Materials
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High-quality draft assemblies of mammalian genomes from massively parallel sequence data.Gnerre, S., Maccallum I., Przybylski D., Ribeiro FJ, Burton JN, Walker BJ, Sharpe T., Hall G., Shea TP, Sykes S., Berlin AM, Aird D., Costello M., Daza R., Williams L., Nicol R., Gnirke A., Nusbaum C., Lander E. S., and Jaffe DB Proceedings of the National Academy of Sciences of the United States of America, 2011/01/25, Volume 108, Issue 4, p.1513-8, (2011) Read More / View Supplemental Materials
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MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13.Sankaran, VG, Menne TF, Šćepanović D., Vergilio JA, Ji P., Kim J., Thiru P., Orkin SH, Lander E. S., and Lodish HF Proceedings of the National Academy of Sciences of the United States of America, 2011/01/25, Volume 108, Issue 4, p.1519-24, (2011) Read More / View Supplemental Materials
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Densely interconnected transcriptional circuits control cell states in human hematopoiesis.Novershtern, N., Subramanian A., Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N., Yosef N., Chang CY, Shay T., Frampton GM, Drake AC, Leskov I., Nilsson B., Preffer F., Dombkowski D., Evans JW, Liefeld T., Smutko JS, Chen J., et al. Cell, 2011/01/21, Volume 144, Issue 2, p.296-309, (2011) Read More / View Supplemental Materials
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Next-generation sequencing for HLA typing of class I loci.Erlich, RL, Jia X., Anderson S., Banks E., Gao X., Carrington M., Gupta N., DePristo MA, Henn MR, Lennon NJ, and de Bakker PI BMC genomics, 2011/01/18, Volume 12, p.42, (2011) Read More / View Supplemental Materials
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PriSM: a primer selection and matching tool for amplification and sequencing of viral genomes.Yu, Q., Ryan EM, Allen TM, Birren BW, Henn MR, and Lennon NJ Bioinformatics (Oxford, England), 2011/01/15, Volume 27, Issue 2, p.266-7, (2011) Read More / View Supplemental Materials
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Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.Rossin, EJ, Lage K., Raychaudhuri S., Xavier RJ, Tatar D., Benita Y., International Inflammatory Bowel Disease Genetics Constortium, Cotsapas C., and Daly M. J. PLoS genetics, 2011/01/13, Volume 7, Issue 1, p.e1001273, (2011) Read More / View Supplemental Materials
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Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes.Shaw, SY, Blodgett DM, Ma MS, Westly EC, Clemons PA, Subramanian A., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2011/01/11, Volume 108, Issue 2, p.492-7, (2011) Read More / View Supplemental Materials
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Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records.Kurreeman, F., Liao K., Chibnik L., Hickey B., Stahl E., Gainer V., Li G., Bry L., Mahan S., Ardlie K., Thomson B., Szolovits P., Churchill S., Murphy SN, Cai T., Raychaudhuri S., Kohane I., Karlson E., and Plenge RM American journal of human genetics, 2011/01/07, Volume 88, Issue 1, p.57-69, (2011) Read More / View Supplemental Materials
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Reprogramming factor expression initiates widespread targeted chromatin remodeling.Koche, RP, Smith ZD, Adli M., Gu H., Ku M., Gnirke A., Bernstein BE, and Meissner A. Cell stem cell, 2011/01/07, Volume 8, Issue 1, p.96-105, (2011) Read More / View Supplemental Materials
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Endurance, refuge, and reemergence of dengue virus type 2, Puerto Rico, 1986-2007.McElroy, KL, Santiago GA, Lennon NJ, Birren BW, Henn MR, and Muñoz-Jordán JL Emerging infectious diseases, 2011/01/01, Volume 17, Issue 1, p.64-71, (2011) Read More / View Supplemental Materials
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Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer.Dutt, A., Ramos AH, Hammerman PS, Mermel C., Cho J., Sharifnia T., Chande A., Tanaka KE, Stransky N., Greulich H., Gray NS, and Meyerson M. PloS one, 2011/01/01, Volume 6, Issue 6, p.e20351, (2011) Read More / View Supplemental Materials
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Integrative genomics viewer.Robinson, JT, Thorvaldsdóttir H., Winckler W., Guttman M., Lander E. S., Getz G., and Mesirov J. P. Nature biotechnology, 2011/01/01, Volume 29, Issue 1, p.24-6, (2011) Read More / View Supplemental Materials
Reducing the Effects of PCR Amplification and Sequencing Artifacts on 16S rRNA-Based Studies.Schloss, PD, Gevers D., and Westcott SL PloS one, 2011/01/01, Volume 6, Issue 12, p.e27310, (2011) Read More / View Supplemental Materials
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2010
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.Johannessen, CM, Boehm JS, Kim SY, Thomas SR, Wardwell L., Johnson LA, Emery CM, Stransky N., Cogdill AP, Barretina J., Caponigro G., Hieronymus H., Murray RR, Salehi-Ashtiani K., Hill DE, Vidal M., Zhao JJ, Yang X., Alkan O., Kim S., et al. Nature, 2010/12/16, Volume 468, Issue 7326, p.968-72, (2010) Read More / View Supplemental Materials
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Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling.Fillmore, CM, Gupta PB, Rudnick JA, Caballero S., Keller PJ, Lander E. S., and Kuperwasser C. Proceedings of the National Academy of Sciences of the United States of America, 2010/12/14, Volume 107, Issue 50, p.21737-42, (2010) Read More / View Supplemental Materials
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An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.Marcaurelle, LA, Comer E., Dandapani S., Duvall JR, Gerard B., Kesavan S., Lee MD 4th, Liu H., Lowe JT, Marie JC, Mulrooney CA, Pandya BA, Rowley A., Ryba TD, Suh BC, Wei J., Young DW, Akella LB, Ross NT, Zhang YL, et al. Journal of the American Chemical Society, 2010/12/01, Volume 132, Issue 47, p.16962-76, (2010) Read More / View Supplemental Materials
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The early whole-blood transcriptional signature of dengue virus and features associated with progression to dengue shock syndrome in Vietnamese children and young adults.Hoang, LT, Lynn DJ, Henn M., Birren BW, Lennon NJ, Le PT, Duong KT, Nguyen TT, Mai LN, Farrar JJ, Hibberd ML, and Simmons CP Journal of virology, 2010/12/01, Volume 84, Issue 24, p.12982-94, (2010) Read More / View Supplemental Materials
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The genomics of lung adenocarcinoma: opportunities for targeted therapies.Greulich, H. Genes & cancer, 2010/12/01, Volume 1, Issue 12, p.1200-10, (2010) Read More / View Supplemental Materials
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Grand challenge commentary: Accessing new chemical space for 'undruggable' targets.Dandapani, S., and Marcaurelle LA Nature chemical biology, 2010/12/01, Volume 6, Issue 12, p.861-3, (2010) Read More / View Supplemental Materials
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Grand challenge commentary: Chemical transdifferentiation and regenerative medicine.Wagner, BK Nature chemical biology, 2010/12/01, Volume 6, Issue 12, p.877-9, (2010) Read More / View Supplemental Materials
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Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.Loewer, S., Cabili MN, Guttman M., Loh YH, Thomas K., Park IH, Garber M., Curran M., Onder T., Agarwal S., Manos PD, Datta S., Lander E. S., Schlaeger TM, Daley GQ, and Rinn JL Nature genetics, 2010/12/01, Volume 42, Issue 12, p.1113-7, (2010) Read More / View Supplemental Materials
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Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity.Chen, J., Armstrong AH, Koehler AN, and Hecht MH Journal of the American Chemical Society, 2010/12/01, Volume 132, Issue 47, p.17015-22, (2010) Read More / View Supplemental Materials
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Nearest template prediction: a single-sample-based flexible class prediction with confidence assessment.Hoshida, Y. PloS one, 2010/11/23, Volume 5, Issue 11, p.e15543, (2010) Read More / View Supplemental Materials
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Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions.Muncipinto, G., Kaya T., Wilson JA, Kumagai N., Clemons PA, and Schreiber SL Organic letters, 2010/11/19, Volume 12, Issue 22, p.5230-3, (2010) Read More / View Supplemental Materials
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Personalized medicine in rheumatoid arthritis: Miles to go before we sleep.Plenge, RM, and Bridges SL Jr Arthritis and rheumatism, 2010/11/04, (2010) Read More / View Supplemental Materials
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.Clemons, PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2010/11/02, Volume 107, Issue 44, p.18787-92, (2010) Read More / View Supplemental Materials
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.Speliotes, EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G., Jackson AU, Allen HL, Lindgren CM, Luan J., Mägi R., Randall JC, Vedantam S., Winkler TW, Qi L., Workalemahu T., Heid IM, Steinthorsdottir V., Stringham HM, Weedon MN, Wheeler E., et al. Nature genetics, 2010/11/01, Volume 42, Issue 11, p.937-48, (2010) Read More / View Supplemental Materials
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Expression analysis of loci associated with type 2 diabetes in human tissues.Cotsapas, C., Prokunina-Olsson L., Welch C., Saxena R., Weaver C., Usher N., Guiducci C., Bonakdar S., Turner N., LaCroix B., and Hall JL Diabetologia, 2010/11/01, Volume 53, Issue 11, p.2334-9, (2010) Read More / View Supplemental Materials
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LRRK2 is involved in the IFN-gamma response and host response to pathogens.Gardet, A., Benita Y., Li C., Sands BE, Ballester I., Stevens C., Korzenik JR, Rioux JD, Daly M. J., Xavier RJ, and Podolsky DK Journal of immunology (Baltimore, Md. : 1950), 2010/11/01, Volume 185, Issue 9, p.5577-85, (2010) Read More / View Supplemental Materials
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Multivariate dependence and genetic networks inference.Margolin, AA, Wang K., Califano A., and Nemenman I. IET systems biology, 2010/11/01, Volume 4, Issue 6, p.428-40, (2010) Read More / View Supplemental Materials
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Points of view: gestalt principles (part 1).Wong, B. Nature methods, 2010/11/01, Volume 7, Issue 11, p.863, (2010) Read More / View Supplemental Materials
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.Green, MR, Monti S., Rodig SJ, Juszczynski P., Currie T., O'Donnell E., Chapuy B., Takeyama K., Neuberg D., Golub T. R., Kutok JL, and Shipp M. A. Blood, 2010/10/28, Volume 116, Issue 17, p.3268-77, (2010) Read More / View Supplemental Materials
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SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes.Neafsey, DE, Lawniczak MK, Park DJ, Redmond SN, Coulibaly MB, Traoré SF, Sagnon N., Costantini C., Johnson C., Wiegand RC, Collins FH, Lander E. S., Wirth DF, Kafatos FC, Besansky NJ, Christophides GK, and Muskavitch MA Science (New York, N.Y.), 2010/10/22, Volume 330, Issue 6003, p.514-7, (2010) Read More / View Supplemental Materials
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Large non-coding RNAs: missing links in cancer?Huarte, M., and Rinn JL Human molecular genetics, 2010/10/15, Volume 19, Issue R2, p.R152-61, (2010) Read More / View Supplemental Materials
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Immunoaffinity Enrichment and Liquid Chromatography-Selected Reaction Monitoring Mass Spectrometry for Quantitation of Carbonic Anhydrase 12 in Cultured Renal Carcinoma Cells.Rafalko, A., Iliopoulos O., Fusaro VA, Hancock W., and Hincapie M. Analytical chemistry, 2010/10/11, (2010) Read More / View Supplemental Materials
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Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.Fass, DM, Shah R., Ghosh B., Hennig K., Norton S., Zhao WN, Reis SA, Klein PS, Mazitschek R., Maglathlin RL, Lewis TA, and Haggarty SJ ACS medicinal chemistry letters, 2010/10/08, Volume 2, Issue 1, p.39-42, (2010) Read More / View Supplemental Materials
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Prepare and inspire.Lander, E. S., and Gates SJ Jr Science (New York, N.Y.), 2010/10/08, Volume 330, Issue 6001, p.151, (2010) Read More / View Supplemental Materials
Comparative epigenomic analysis of murine and human adipogenesis.Mikkelsen, TS, Xu Z., Zhang X., Wang L., Gimble JM, Lander E. S., and Rosen ED Cell, 2010/10/01, Volume 143, Issue 1, p.156-69, (2010) Read More / View Supplemental Materials
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The NIH Roadmap Epigenomics Mapping Consortium.Bernstein, BE, Stamatoyannopoulos JA, Costello JF, Ren B., Milosavljevic A., Meissner A., Kellis M., Marra MA, Beaudet AL, Ecker JR, Farnham PJ, Hirst M., Lander E. S., Mikkelsen TS, and Thomson JA Nature biotechnology, 2010/10/01, Volume 28, Issue 10, p.1045-8, (2010) Read More / View Supplemental Materials
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Quantitative comparison of genome-wide DNA methylation mapping technologies.Bock, C., Tomazou EM, Brinkman AB, Müller F., Simmer F., Gu H., Jäger N., Gnirke A., Stunnenberg HG, and Meissner A. Nature biotechnology, 2010/10/01, Volume 28, Issue 10, p.1106-14, (2010) Read More / View Supplemental Materials
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Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres.O'Sullivan, RJ, Kubicek S., Schreiber SL, and Karlseder J. Nature structural & molecular biology, 2010/10/01, Volume 17, Issue 10, p.1218-25, (2010) Read More / View Supplemental Materials
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The mitochondrial proteome and human disease.Calvo, SE, and Mootha VK Annual review of genomics and human genetics, 2010/09/22, Volume 11, p.25-44, (2010) Read More / View Supplemental Materials
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A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity.Urgaonkar, S., Cortese JF, Barker RH, Cromwell M., Serrano AE, Wirth DF, Clardy J., and Mazitschek R. Organic letters, 2010/09/17, Volume 12, Issue 18, p.3998-4001, (2010) Read More / View Supplemental Materials
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MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake.Perocchi, F., Gohil VM, Girgis HS, Bao XR, McCombs JE, Palmer AE, and Mootha VK Nature, 2010/09/16, Volume 467, Issue 7313, p.291-6, (2010) Read More / View Supplemental Materials
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Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function.Raychaudhuri, S., Korn JM, McCarroll SA, International Schizophrenia Consortium, Altshuler D., Sklar P., Purcell S., and Daly M. J. PLoS genetics, 2010/09/09, Volume 6, Issue 9, (2010) Read More / View Supplemental Materials
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Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.JG, Ren, P Seth, CB Clish, P Everett, and VP Sukhatme PloS one, 2010/09/02, Volume 5, Issue 9, (2010) Read More / View Supplemental Materials
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Integrating common and rare genetic variation in diverse human populations.International HapMap 3, Consortium, Altshuler DM, Gibbs RA, Peltonen L., Altshuler DM, Gibbs RA, Peltonen L., Dermitzakis E., Schaffner SF, Yu F., Peltonen L., Dermitzakis E., Bonnen PE, Altshuler DM, Gibbs RA, de Bakker PI, Deloukas P., Gabriel SB, Gwilliam R., Hunt S., et al. Nature, 2010/09/02, Volume 467, Issue 7311, p.52-8, (2010) Read More / View Supplemental Materials
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