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2014
Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).Chhibber, A., Mefford J., Stahl EA, Pendergrass SA, Baldwin RM, Owzar K., Li M., Winer EP, Hudis CA, Zembutsu H., Kubo M., Nakamura Y., McLeod HL, Ratain MJ, Shulman LN, Ritchie MD, Plenge RM, Witte JS, and Kroetz DL The pharmacogenomics journal, 2014/02/11, (2014) Read More / View Supplemental Materials
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SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia.Puissant, A., Fenouille N., Alexe G., Pikman Y., Bassil CF, Mehta S., Du J., Kazi JU, Luciano F., Rönnstrand L., Kung AL, Aster J. C., Galinsky I., Stone RM, DeAngelo DJ, Hemann MT, and Stegmaier K. Cancer cell, 2014/02/10, Volume 25, Issue 2, p.226-42, (2014) Read More / View Supplemental Materials
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The antidepressant age.Hyman, SE Nature medicine, 2014/02/06, Volume 20, Issue 2, p.118-9, (2014) Read More / View Supplemental Materials
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.Peloso, GM, Auer PL, Bis JC, Voorman A., Morrison AC, Stitziel NO, Brody JA, Khetarpal SA, Crosby JR, Fornage M., Isaacs A., Jakobsdottir J., Feitosa MF, Davies G., Huffman JE, Manichaikul A., Davis B., Lohman K., Joon AY, Smith AV, et al. American journal of human genetics, 2014/02/06, Volume 94, Issue 2, p.223-32, (2014) Read More / View Supplemental Materials
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Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease.Bennett, DA, Yu L., and De Jager PL Biochemical pharmacology, 2014/02/06, (2014) Read More / View Supplemental Materials
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Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission.Rooks, MG, Veiga P., Wardwell-Scott LH, Tickle T., Segata N., Michaud M., Gallini CA, Beal C., van Hylckama-Vlieg JE, Ballal SA, Morgan XC, Glickman JN, Gevers D., Huttenhower C., and Garrett WS The ISME journal, 2014/02/06, (2014) Read More / View Supplemental Materials
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In vivo discovery of immunotherapy targets in the tumour microenvironment.Zhou, P., Shaffer DR, Alvarez Arias DA, Nakazaki Y., Pos W., Torres AJ, Cremasco V., Dougan SK, Cowley GS, Elpek K., Brogdon J., Lamb J., Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G., Hacohen N., Cantor H., and Wucherpfennig KW Nature, 2014/02/06, Volume 506, Issue 7486, p.52-7, (2014) Read More / View Supplemental Materials
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Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol.Lange, LA, Hu Y., Zhang H., Xue C., Schmidt EM, Tang ZZ, Bizon C., Lange EM, Smith JD, Turner EH, Jun G., Kang HM, Peloso G., Auer P., Li KP, Flannick J., Zhang J., Fuchsberger C., Gaulton K., Lindgren C., et al. American journal of human genetics, 2014/02/06, Volume 94, Issue 2, p.233-45, (2014) Read More / View Supplemental Materials
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Genetic variation of oxidative phosphorylation genes in stroke and Alzheimer's disease.Biffi, A., Sabuncu MR, Desikan RS, Schmansky N., Salat DH, Rosand J., Anderson CD, and Alzheimer's disease Neuroimaging Initiative(ADNI) Neurobiology of aging, 2014/02/05, (2014) Read More / View Supplemental Materials
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Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model.Zhao, T., Li Y., Liu B., Halaweish I., Mazitschek R., and Alam HB The Journal of surgical research, 2014/02/04, (2014) Read More / View Supplemental Materials
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Extracting data from the muck: deriving biological insight from complex microbial communities and non-model organisms with next generation sequencing.Solomon, KV, Haitjema CH, Thompson DA, and O'Malley MA Current opinion in biotechnology, 2014/02/03, Volume 28C, p.103-110, (2014) Read More / View Supplemental Materials
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Advantages and pitfalls in the application of mixed-model association methods.Yang, J., Zaitlen NA, Goddard ME, Visscher PM, and Price AL Nature genetics, 2014/02/01, Volume 46, Issue 2, p.100-6, (2014) Read More / View Supplemental Materials
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Analysis of copy number variations at 15 schizophrenia-associated loci.Rees, E., Walters JT, Georgieva L., Isles AR, Chambert KD, Richards AL, Mahoney-Davies G., Legge SE, Moran JL, McCarroll SA, O'Donovan MC, Owen MJ, and Kirov G. The British journal of psychiatry : the journal of mental science, 2014/02/01, Volume 204, Issue 2, p.108-14, (2014) Read More / View Supplemental Materials
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Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons.Fischer, K., Kettunen J., Würtz P., Haller T., Havulinna AS, Kangas AJ, Soininen P., Esko T., Tammesoo ML, Mägi R., Smit S., Palotie A., Ripatti S., Salomaa V., Ala-Korpela M., Perola M., and Metspalu A. PLoS medicine, 2014/02/01, Volume 11, Issue 2, p.e1001606, (2014) Read More / View Supplemental Materials
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Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24.Agler, C., Nielsen DM, Urkasemsin G., Singleton A., Tonomura N., Sigurdsson S., Tang R., Linder K., Arepalli S., Hernandez D., Lindblad-Toh K., van de Leemput J., Motsinger-Reif A., O'Brien DP, Bell J., Harris T., Steinberg S., and Olby NJ PLoS genetics, 2014/02/01, Volume 10, Issue 2, p.e1003991, (2014) Read More / View Supplemental Materials
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Chromosome x-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.Tukiainen, T., Pirinen M., Sarin AP, Ladenvall C., Kettunen J., Lehtimäki T., Lokki ML, Perola M., Sinisalo J., Vlachopoulou E., Eriksson JG, Groop L., Jula A., Järvelin MR, Raitakari OT, Salomaa V., and Ripatti S. PLoS genetics, 2014/02/01, Volume 10, Issue 2, p.e1004127, (2014) Read More / View Supplemental Materials
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Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins.Kennedy, JJ, Abbatiello SE, Kim K., Yan P., Whiteaker JR, Lin C., Kim JS, Zhang Y., Wang X., Ivey RG, Zhao L., Min H., Lee Y., Yu MH, Yang EG, Lee C., Wang P., Rodriguez H., Kim Y., Carr SA, et al. Nature methods, 2014/02/01, Volume 11, Issue 2, p.149-55, (2014) Read More / View Supplemental Materials
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Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas.Brastianos, PK, Taylor-Weiner A., Manley PE, Jones RT, Dias-Santagata D., Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L., Sunkavalli A., Shillingford N., Calicchio ML, Lidov HG, Taha H., Martinez-Lage M., Santi M., Storm PB, Lee JY, Palmer JN, et al. Nature genetics, 2014/02/01, Volume 46, Issue 2, p.161-5, (2014) Read More / View Supplemental Materials
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Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain.Colgrove, R., Diaz F., Newman R., Saif S., Shea T., Young S., Henn M., and Knipe DM Virology, 2014/02/01, Volume 450-451, p.140-5, (2014) Read More / View Supplemental Materials
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Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth.Stanley, SA, Barczak AK, Silvis MR, Luo SS, Sogi K., Vokes M., Bray MA, Carpenter AE, Moore CB, Siddiqi N., Rubin EJ, and Hung DT PLoS pathogens, 2014/02/01, Volume 10, Issue 2, p.e1003946, (2014) Read More / View Supplemental Materials
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The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection.Filone, CM, Caballero IS, Dower K., Mendillo ML, Cowley GS, Santagata S., Rozelle DK, Yen J., Rubins KH, Hacohen N., Root DE, Hensley LE, and Connor J. PLoS pathogens, 2014/02/01, Volume 10, Issue 2, p.e1003904, (2014) Read More / View Supplemental Materials
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Recent discoveries and applications involving small-molecule microarrays.Hong, JA, Neel DV, Wassaf D., Caballero F., and Koehler AN Current opinion in chemical biology, 2014/02/01, Volume 18C, p.21-28, (2014) Read More / View Supplemental Materials
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Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre.Hacisuleyman, E., Goff LA, Trapnell C., Williams A., Henao-Mejia J., Sun L., McClanahan P., Hendrickson DG, Sauvageau M., Kelley DR, Morse M., Engreitz J., Lander E. S., Guttman M., Lodish HF, Flavell R., Raj A., and Rinn JL Nature structural & molecular biology, 2014/02/01, Volume 21, Issue 2, p.198-206, (2014) Read More / View Supplemental Materials
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The evolution of lncRNA repertoires and expression patterns in tetrapods.Necsulea, A., Soumillon M., Warnefors M., Liechti A., Daish T., Zeller U., Baker JC, Grützner F., and Kaessmann H. Nature, 2014/01/30, Volume 505, Issue 7485, p.635-40, (2014) Read More / View Supplemental Materials
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Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests.Deme, AB, Park DJ, Bei AK, Sarr O., Badiane AS, Gueye Pel H., Ahouidi A., Ndir O., Mboup S., Wirth DF, Ndiaye D., and Volkman SK Malaria journal, 2014/01/29, Volume 13, Issue 1, p.34, (2014) Read More / View Supplemental Materials
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The genomic landscape of Neanderthal ancestry in present-day humans.Sankararaman, S., Mallick S., Dannemann M., Prüfer K., Kelso J., Pääbo S., Patterson N., and Reich D. Nature, 2014/01/29, (2014) Read More / View Supplemental Materials
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Meta'omic Analytic Techniques for Studying the Intestinal Microbiome.Morgan, XC, and Huttenhower C. Gastroenterology, 2014/01/28, (2014) Read More / View Supplemental Materials
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Searching for missing heritability: Designing rare variant association studies.Zuk, O., Schaffner SF, Samocha K., Do R., Hechter E., Kathiresan S., Daly M. J., Neale BM, Sunyaev SR, and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2014/01/28, Volume 111, Issue 4, p.E455-64, (2014) Read More / View Supplemental Materials
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Oncogenic RIT1 mutations in lung adenocarcinoma.Berger, AH, Imielinski M., Duke F., Wala J., Kaplan N., Shi GX, Andres DA, and Meyerson M. Oncogene, 2014/01/27, (2014) Read More / View Supplemental Materials
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Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European.Olalde, I., Allentoft ME, Sánchez-Quinto F., Santpere G., Chiang CW, Degiorgio M., Prado-Martinez J., Rodríguez JA, Rasmussen S., Quilez J., Ramírez O., Marigorta UM, Fernández-Callejo M., Prada ME, Encinas JM, Nielsen R., Netea MG, Novembre J., Sturm RA, Sabeti P., et al. Nature, 2014/01/26, (2014) Read More / View Supplemental Materials
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Epigenome-wide association studies without the need for cell-type composition.Zou, J., Lippert C., Heckerman D., Aryee M., and Listgarten J. Nature methods, 2014/01/26, (2014) Read More / View Supplemental Materials
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Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.Dancík, V., Carrel H., Bodycombe NE, Seiler KP, Fomina-Yadlin D., Kubicek ST, Hartwell K., Shamji AF, Wagner BK, and Clemons PA Journal of biomolecular screening, 2014/01/24, (2014) Read More / View Supplemental Materials
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Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.Nilsson, R., Jain M., Madhusudhan N., Sheppard NG, Strittmatter L., Kampf C., Huang J., Asplund A., and Mootha VK Nature communications, 2014/01/23, Volume 5, p.3128, (2014) Read More / View Supplemental Materials
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Translation of branched-chain aminotransferase-1 transcripts is impaired in cells haploinsufficient for ribosomal protein genes.Pereboom, TC, Bondt A., Pallaki P., Klasson T., Goos YJ, Essers PB, Koerkamp MG, Gazda HT, Holstege FC, and Macinnes AW Experimental hematology, 2014/01/23, (2014) Read More / View Supplemental Materials
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Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data.Radmanesh, F., Devan WJ, Anderson CD, Rosand J., and Falcone GJ European journal of human genetics : EJHG, 2014/01/22, (2014) Read More / View Supplemental Materials
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SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.Fowler, SA, Ananthakrishnan AN, Gardet A., Stevens CR, Korzenik JR, Sands BE, Daly M. J., Xavier RJ, and Yajnik V. Journal of Crohn's & colitis, 2014/01/22, (2014) Read More / View Supplemental Materials
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Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21.Hamrefors, V., Hedblad B., Hindy G., Smith JG, Almgren P., Engström G., Sjögren M., Gränsbo K., Orho-Melander M., and Melander O. PloS one, 2014/01/22, Volume 9, Issue 1, p.e85893, (2014) Read More / View Supplemental Materials
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In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene.Dunn, GP, Cheung HW, Agarwalla PK, Thomas S., Zektser Y., Karst AM, Boehm JS, Weir BA, Berlin AM, Zou L., Getz G., Liu JF, Hirsch M., Vazquez F., Root DE, Beroukhim R., Drapkin R., and Hahn WC Proceedings of the National Academy of Sciences of the United States of America, 2014/01/21, Volume 111, Issue 3, p.1102-7, (2014) Read More / View Supplemental Materials
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Inference of Tumor Evolution during Chemotherapy by Computational Modeling and In Situ Analysis of Genetic and Phenotypic Cellular Diversity.Almendro, V., Cheng YK, Randles A., Itzkovitz S., Marusyk A., Ametller E., Gonzalez-Farre X., Muñoz M., Russnes HG, Helland A., Rye IH, Borresen-Dale AL, Maruyama R., van Oudenaarden A., Dowsett M., Jones RL, Reis-Filho J., Gascon P., Gönen M., Michor F., et al. Cell reports, 2014/01/21, (2014) Read More / View Supplemental Materials
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Strength in numbers: comparing vaccine signatures the modular way.Haining, WN Nature immunology, 2014/01/21, Volume 15, Issue 2, p.139-41, (2014) Read More / View Supplemental Materials
Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.Zhu, Z., Aref AR, Cohoon TJ, Barbie TU, Imamura Y., Yang S., Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P., Godfrey JT, Qian ZR, Page AN, Maciag K., Chan EM, Silkworth W., Labowsky MT, Rozhansky L., et al. Cancer discovery, 2014/01/20, (2014) Read More / View Supplemental Materials
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Rare Copy Number Variation in Treatment-Resistant Major Depressive Disorder.O'Dushlaine, C., Ripke S., Ruderfer DM, Hamilton SP, Fava M., Iosifescu DV, Kohane IS, Churchill SE, Castro VM, Clements CC, Blumenthal SR, Murphy SN, Smoller JW, and Perlis RH Biological psychiatry, 2014/01/19, (2014) Read More / View Supplemental Materials
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The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated with Panic Disorder and Amygdala Structure and Function.Smoller, JW, Gallagher PJ, Duncan LE, McGrath LM, Haddad SA, Holmes AJ, Wolf AB, Hilker S., Block SR, Weill S., Young S., Choi EY, Rosenbaum JF, Biederman J., Faraone SV, Roffman JL, Manfro GG, Blaya C., Hirshfeld-Becker DR, Stein MB, et al. Biological psychiatry, 2014/01/18, (2014) Read More / View Supplemental Materials
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Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.Krönke, J., Udeshi ND, Narla A., Grauman P., Hurst SN, McConkey M., Svinkina T., Heckl D., Comer E., Li X., Ciarlo C., Hartman E., Munshi N., Schenone M., Schreiber SL, Carr SA, and Ebert BL Science (New York, N.Y.), 2014/01/17, Volume 343, Issue 6168, p.301-5, (2014) Read More / View Supplemental Materials
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Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories.Gräff, J., Joseph NF, Horn ME, Samiei A., Meng J., Seo J., Rei D., Bero AW, Phan TX, Wagner F., Holson E., Xu J., Sun J., Neve RL, Mach RH, Haggarty SJ, and Tsai LH Cell, 2014/01/16, Volume 156, Issue 1-2, p.261-76, (2014) Read More / View Supplemental Materials
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A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility.Damotte, V., Guillot-Noel L., Patsopoulos NA, Madireddy L., El Behi M., International Multiple Sclerosis Genetics Consortium, Ban M., Baranzini S., Barcellos L., Beecham G., Beecham A., Bernardinelli L., Booth D., Bos S., Buck D., Bush W., Comabella M., Compston A., Cotsapas C., Cournu-Rebeix I., et al. Genes and immunity, 2014/01/16, (2014) Read More / View Supplemental Materials
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The multilayered complexity of ceRNA crosstalk and competition.Tay, Y., Rinn J., and Pandolfi PP Nature, 2014/01/16, Volume 505, Issue 7483, p.344-52, (2014) Read More / View Supplemental Materials
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Multilocus Genetic Risk Score Associates With Ischemic Stroke in Case-Control and Prospective Cohort Studies.Malik, R., Bevan S., Nalls MA, Holliday EG, Devan WJ, Cheng YC, Ibrahim-Verbaas CA, Verhaaren BF, Bis JC, Joon AY, Destefano AL, Fornage M., Psaty BM, Ikram MA, Launer LJ, van Duijn CM, Sharma P., Mitchell BD, Rosand J., Meschia JF, et al. Stroke; a journal of cerebral circulation, 2014/01/16, (2014) Read More / View Supplemental Materials
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Predicting Stroke Through Genetic Risk Functions: The CHARGE Risk Score Project.Ibrahim-Verbaas, CA, Fornage M., Bis JC, Choi SH, Psaty BM, Meigs JB, Rao M., Nalls M., Fontes JD, O'Donnell CJ, Kathiresan S., Ehret GB, Fox CS, Malik R., Dichgans M., Schmidt H., Lahti J., Heckbert SR, Lumley T., Rice K., et al. Stroke; a journal of cerebral circulation, 2014/01/16, (2014) Read More / View Supplemental Materials
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Regulation of Ferroptotic Cancer Cell Death by GPX4.Yang, WS, Sriramaratnam R., Welsch ME, Shimada K., Skouta R., Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, and Stockwell BR Cell, 2014/01/16, Volume 156, Issue 1-2, p.317-31, (2014) Read More / View Supplemental Materials
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What we talk about when we talk about fat.Rosen, ED, and Spiegelman BM Cell, 2014/01/16, Volume 156, Issue 1-2, p.20-44, (2014) Read More / View Supplemental Materials
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Insights from monogenic diabetes and glycemic treatment goals for common types of diabetes.Florez, JC JAMA : the journal of the American Medical Association, 2014/01/15, Volume 311, Issue 3, p.249-51, (2014) Read More / View Supplemental Materials
Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance.Kats, LM, Reschke M., Taulli R., Pozdnyakova O., Burgess K., Bhargava P., Straley K., Karnik R., Meissner A., Small D., Su SM, Yen K., Zhang J., and Pandolfi PP Cell stem cell, 2014/01/15, (2014) Read More / View Supplemental Materials
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ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State.Chudnovsky, Y., Kim D., Zheng S., Whyte WA, Bansal M., Bray MA, Gopal S., Theisen MA, Bilodeau S., Thiru P., Muffat J., Yilmaz OH, Mitalipova M., Woolard K., Lee J., Nishimura R., Sakata N., Fine HA, Carpenter AE, Silver SJ, et al. Cell reports, 2014/01/15, (2014) Read More / View Supplemental Materials
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Autophagy is essential for cardiac morphogenesis during vertebrate development.Lee, E., Koo Y., Ng A., Wei Y., Luby-Phelps K., Juraszek A., Xavier RJ, Cleaver O., Levine B., and Amatruda JF Autophagy, 2014/01/14, Volume 10, Issue 4, (2014) Read More / View Supplemental Materials
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Differential Effect of Genetic Burden on Disease Phenotypes in Crohn's Disease and Ulcerative Colitis: Analysis of a North American Cohort.Ananthakrishnan, AN, Huang H., Nguyen DD, Sauk J., Yajnik V., and Xavier RJ The American journal of gastroenterology, 2014/01/14, (2014) Read More / View Supplemental Materials
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Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance.Lukens, AK, Ross LS, Heidebrecht R., Javier Gamo F., Lafuente-Monasterio MJ, Booker ML, Hartl DL, Wiegand RC, and Wirth DF Proceedings of the National Academy of Sciences of the United States of America, 2014/01/14, Volume 111, Issue 2, p.799-804, (2014) Read More / View Supplemental Materials
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De novo fatty acid synthesis at the mitotic exit is required to complete cellular division.Scaglia, N., Tyekucheva S., Zadra G., Photopoulos C., and Loda M. Cell cycle (Georgetown, Tex.), 2014/01/13, Volume 13, Issue 5, (2014) Read More / View Supplemental Materials
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Using transcription of six Puccinia triticina races to identify the effective secretome during infection of wheat.Bruce, M., Neugebauer KA, Joly DL, Migeon P., Cuomo CA, Wang S., Akhunov E., Bakkeren G., Kolmer JA, and Fellers JP Frontiers in plant science, 2014/01/13, Volume 4, p.520, (2014) Read More / View Supplemental Materials
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Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.Lohr, JG, Stojanov P., Carter SL, Cruz-Gordillo P., Lawrence MS, Auclair D., Sougnez C., Knoechel B., Gould J., Saksena G., Cibulskis K., McKenna A., Chapman MA, Straussman R., Levy J., Perkins LM, Keats JJ, Schumacher SE, Rosenberg M., Multiple Myeloma Research Consortium, et al. Cancer cell, 2014/01/13, Volume 25, Issue 1, p.91-101, (2014) Read More / View Supplemental Materials
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Common Variation in Fatty Acid Metabolic Genes and Risk of Incident Sudden Cardiac Arrest.Lemaitre, RN, Johnson CO, Hesselson S., Sotoodhenia N., McKnight B., Sitlani CM, Rea TD, King IB, Kwok PY, Mak A., Li G., Brody J., Larson E., Mozaffarian D., Psaty BM, Huertas-Vazquez A., Tardif JC, Albert CM, Lyytikäinen LP, Arking DE, et al. Heart rhythm : the official journal of the Heart Rhythm Society, 2014/01/10, (2014) Read More / View Supplemental Materials
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β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors.Roberts, LD, Boström P., O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A., Lee YK, Palma MJ, Calhoun S., Georgiadi A., Chen MH, Ramachandran VS, Larson MG, Bouchard C., Rankinen T., Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, et al. Cell metabolism, 2014/01/07, Volume 19, Issue 1, p.96-108, (2014) Read More / View Supplemental Materials
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Discovery and saturation analysis of cancer genes across 21 tumour types.Lawrence, MS, Stojanov P., Mermel CH, Robinson JT, Garraway LA, Golub T. R., Meyerson M., Gabriel SB, Lander E. S., and Getz G. Nature, 2014/01/05, (2014) Read More / View Supplemental Materials
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Genome-scale CRISPR-Cas9 knockout screening in human cells.Shalem, O., Sanjana NE, Hartenian E., Shi X., Scott DA, Mikkelsen TS, Heckl D., Ebert BL, Root DE, Doench JG, and Zhang F. Science (New York, N.Y.), 2014/01/03, Volume 343, Issue 6166, p.84-7, (2014) Read More / View Supplemental Materials
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The complete genome sequence of a Neanderthal from the Altai Mountains.Prüfer, K., Racimo F., Patterson N., Jay F., Sankararaman S., Sawyer S., Heinze A., Renaud G., Sudmant PH, de Filippo C., Li H., Mallick S., Dannemann M., Fu Q., Kircher M., Kuhlwilm M., Lachmann M., Meyer M., Ongyerth M., Siebauer M., et al. Nature, 2014/01/02, Volume 505, Issue 7481, p.43-9, (2014) Read More / View Supplemental Materials
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The influence of polygenic risk scores on heritability of anti-CCP level in RA.Cui, J., Taylor KE, Lee YC, Källberg H., Weinblatt ME, Coblyn JS, Klareskog L., Criswell LA, Gregersen PK, Shadick NA, Plenge RM, and Karlson EW Genes and immunity, 2014/01/02, (2014) Read More / View Supplemental Materials
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Mutations in CSPP1 Lead to Classical Joubert Syndrome.Akizu, N., Silhavy JL, Rosti RO, Scott E., Fenstermaker AG, Schroth J., Zaki MS, Sanchez H., Gupta N., Kabra M., Kara M., Ben-Omran T., Rosti B., Guemez-Gamboa A., Spencer E., Pan R., Cai N., Abdellateef M., Gabriel S., Halbritter J., et al. American journal of human genetics, 2014/01/02, Volume 94, Issue 1, p.80-6, (2014) Read More / View Supplemental Materials
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Probiotic microbes sustain youthful serum testosterone levels and testicular size in aging mice.Poutahidis, T., Springer A., Levkovich T., Qi P., Varian BJ, Lakritz JR, Ibrahim YM, Chatzigiagkos A., Alm EJ, and Erdman SE PloS one, 2014/01/02, Volume 9, Issue 1, p.e84877, (2014) Read More / View Supplemental Materials
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16S rRNA Gene Survey of Microbial Communities in Winogradsky Columns.Rundell, EA, Banta LM, Ward DV, Watts CD, Birren B., and Esteban DJ PloS one, 2014/01/01, Volume 9, Issue 8, p.e104134, (2014) Read More / View Supplemental Materials
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An Adjustable Gas-Mixing Device to Increase Feasibility of In Vitro Culture of Plasmodium falciparum Parasites in the Field.Bei, AK, Patel SD, Volkman SK, Ahouidi AD, Ndiaye D., Mboup S., and Wirth DF PloS one, 2014/01/01, Volume 9, Issue 3, p.e90928, (2014) Read More / View Supplemental Materials
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Allele-specific methylation occurs at genetic variants associated with complex disease.Hutchinson, JN, Raj T., Fagerness J., Stahl E., Viloria FT, Gimelbrant A., Seddon J., Daly M., Chess A., and Plenge R. PloS one, 2014/01/01, Volume 9, Issue 6, p.e98464, (2014) Read More / View Supplemental Materials
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Analysis of gene-gene interactions among common variants in coronary artery disease.Musameh, M., Wang W., Nelson C., Lluís-Ganella C., Subirana I., Elosua R., Hall A., Kathiresan S., Samani N., and Tomaszewski M. Heart, lung & circulation, 2014/01/01, Volume 23 Suppl 2, p.e19, (2014) Read More / View Supplemental Materials
Analysis of the Effects of Five Factors Relevant to In Vitro Chondrogenesis of Human Mesenchymal Stem Cells Using Factorial Design and High Throughput mRNA-Profiling.Jakobsen, RB, Ostrup E., Zhang X., Mikkelsen TS, and Brinchmann JE PloS one, 2014/01/01, Volume 9, Issue 5, p.e96615, (2014) Read More / View Supplemental Materials
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CELLCOUNTER: Novel Open-Source Software for Counting Cell Migration and Invasion In Vitro.Li, X., Yang H., Huang H., and Zhu T. BioMed research international, 2014/01/01, Volume 2014, p.863564, (2014) Read More / View Supplemental Materials
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Comorbidity of Severe Psychotic Disorders With Measures of Substance Use.Hartz, SM, Pato CN, Medeiros H., Cavazos-Rehg P., Sobell JL, Knowles JA, Bierut LJ, Pato MT, for the Genomic Psychiatry Cohort Consortium, Abbott C., Azevedo MH, Belliveau R., Bevilacqua E., Bromet EJ, Buckley PF, Dewan MJ, Escamilla MA, Fanous AH, Fochtmann LJ, Kinkead R., et al. JAMA psychiatry, 2014/01/01, (2014) Read More / View Supplemental Materials
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Comparison of illumina and 454 deep sequencing in participants failing raltegravir-based antiretroviral therapy.Li, JZ, Chapman B., Charlebois P., Hofmann O., Weiner B., Porter AJ, Samuel R., Vardhanabhuti S., Zheng L., Eron J., Taiwo B., Zody MC, Henn MR, Kuritzkes DR, Hide W., ACTG A5262 Study Team, Wilson CC, Berzins BI, Acosta EP, Bastow B., et al. PloS one, 2014/01/01, Volume 9, Issue 3, p.e90485, (2014) Read More / View Supplemental Materials
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Comprehensive functional annotation of 77 prostate cancer risk Loci.Hazelett, DJ, Rhie SK, Gaddis M., Yan C., Lakeland DL, Coetzee SG, consortium Ellipse/GAME-ON, consortium Practical, Henderson BE, Noushmehr H., Cozen W., Kote-Jarai Z., Eeles RA, Easton DF, Haiman CA, Lu W., Farnham PJ, and Coetzee GA PLoS genetics, 2014/01/01, Volume 10, Issue 1, p.e1004102, (2014) Read More / View Supplemental Materials
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Construction and application of a korean reference panel for imputing classical alleles and amino acids of human leukocyte antigen genes.Kim, K., Bang SY, Lee HS, and Bae SC PloS one, 2014/01/01, Volume 9, Issue 11, p.e112546, (2014) Read More / View Supplemental Materials
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CRISPRseek: A Bioconductor Package to Identify Target-Specific Guide RNAs for CRISPR-Cas9 Genome-Editing Systems.Zhu, LJ, Holmes BR, Aronin N., and Brodsky MH PloS one, 2014/01/01, Volume 9, Issue 9, p.e108424, (2014) Read More / View Supplemental Materials
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Cytoscape: the network visualization tool for GenomeSpace workflows.Demchak, B., Hull T., Reich M., Liefeld T., Smoot M., Ideker T., and Mesirov J. P. F1000Research, 2014/01/01, Volume 3, p.151, (2014) Read More / View Supplemental Materials
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A Description of the Molecular Signatures Database (MSigDB) Web Site.Liberzon, A. Methods in molecular biology (Clifton, N.J.), 2014/01/01, Volume 1150, p.153-60, (2014) Read More / View Supplemental Materials
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Dopamine genetic risk score predicts depressive symptoms in healthy adults and adults with depression.Pearson-Fuhrhop, KM, Dunn EC, Mortero S., Devan WJ, Falcone GJ, Lee P., Holmes AJ, Hollinshead MO, Roffman JL, Smoller JW, Rosand J., and Cramer SC PloS one, 2014/01/01, Volume 9, Issue 5, p.e93772, (2014) Read More / View Supplemental Materials
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Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs.Gagnon, JA, Valen E., Thyme SB, Huang P., Ahkmetova L., Pauli A., Montague TG, Zimmerman S., Richter C., and Schier AF PloS one, 2014/01/01, Volume 9, Issue 5, p.e98186, (2014) Read More / View Supplemental Materials
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Evidence that duplications of 22q11.2 protect against schizophrenia.Rees, E., Kirov G., Sanders A., Walters JT, Chambert KD, Shi J., Szatkiewicz J., O'Dushlaine C., Richards AL, Green EK, Jones I., Davies G., Legge SE, Moran JL, Pato C., Pato M., Genovese G., Levinson D., Duan J., Moy W., et al. Molecular psychiatry, 2014/01/01, Volume 19, Issue 1, p.37-40, (2014) Read More / View Supplemental Materials
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Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.Escott-Price, V., Bellenguez C., Wang LS, Choi SH, Harold D., Jones L., Holmans P., Gerrish A., Vedernikov A., Richards A., Destefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R., Jun G., Bis JC, Beecham GW, Grenier-Boley B., Russo G., et al. PloS one, 2014/01/01, Volume 9, Issue 6, p.e94661, (2014) Read More / View Supplemental Materials
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Genetics and epigenetics of gliomas.Suvà, ML Swiss medical weekly, 2014/01/01, Volume 144, p.w14018, (2014) Read More / View Supplemental Materials
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Genome editing using cas9 nickases.Trevino, AE, and Zhang F. Methods in enzymology, 2014/01/01, Volume 546, p.161-74, (2014) Read More / View Supplemental Materials
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Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges.Diogo, D., Okada Y., and Plenge RM Current opinion in rheumatology, 2014/01/01, Volume 26, Issue 1, p.85-92, (2014) Read More / View Supplemental Materials
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Gut Microbiota and the Paradox of Cancer Immunotherapy.Poutahidis, T., Kleinewietfeld M., and Erdman SE Frontiers in immunology, 2014/01/01, Volume 5, p.157, (2014) Read More / View Supplemental Materials
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High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons.Nieland, TJ, Logan DJ, Saulnier J., Lam D., Johnson C., Root DE, Carpenter AE, and Sabatini BL PloS one, 2014/01/01, Volume 9, Issue 3, p.e91744, (2014) Read More / View Supplemental Materials
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High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms.Kurki, MI, Gaál EI, Kettunen J., Lappalainen T., Menelaou A., Anttila V., van 't Hof FN, von Und Zu Fraunberg M., Helisalmi S., Hiltunen M., Lehto H., Laakso A., Kivisaari R., Koivisto T., Ronkainen A., Rinne J., Kiemeney LA, Vermeulen SH, Kaunisto MA, Eriksson JG, et al. PLoS genetics, 2014/01/01, Volume 10, Issue 1, p.e1004134, (2014) Read More / View Supplemental Materials
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Identification of ALK Gene Alterations in Urothelial Carcinoma.Bellmunt, J., Selvarajah S., Rodig S., Salido M., de Muga S., Costa I., Bellosillo B., Werner L., Mullane S., Fay AP, O'Brien R., Barretina J., Minoche AE, Signoretti S., Montagut C., Himmelbauer H., Berman DM, Kantoff P., Choueiri TK, and Rosenberg JE PloS one, 2014/01/01, Volume 9, Issue 8, p.e103325, (2014) Read More / View Supplemental Materials
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An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse.Liao, J., Jijon HB, Kim IR, Goel G., Doan A., Sokol H., Bauer H., Herrmann BG, Lassen KG, and Xavier RJ PloS one, 2014/01/01, Volume 9, Issue 9, p.e108777, (2014) Read More / View Supplemental Materials
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An improved canine genome and a comprehensive catalogue of coding genes and non-coding transcripts.Hoeppner, MP, Lundquist A., Pirun M., Meadows JR, Zamani N., Johnson J., Sundström G., Cook A., FitzGerald MG, Swofford R., Mauceli E., Moghadam BT, Greka A., Alföldi J., Abouelleil A., Aftuck L., Bessette D., Berlin A., Brown A., Gearin G., et al. PloS one, 2014/01/01, Volume 9, Issue 3, p.e91172, (2014) Read More / View Supplemental Materials
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Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene.Okada, Y., Diogo D., Greenberg JD, Mouassess F., Achkar WA, Fulton RS, Denny JC, Gupta N., Mirel D., Gabriel S., Li G., Kremer JM, Pappas DA, Carroll RJ, Eyler AE, Trynka G., Stahl EA, Cui J., Saxena R., Coenen MJ, et al. PloS one, 2014/01/01, Volume 9, Issue 2, p.e87645, (2014) Read More / View Supplemental Materials
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Intestinal microbiota of preterm infants differ over time and between hospitals.Taft, DH, Ambalavanan N., Schibler KR, Yu Z., Newburg DS, Ward DV, and Morrow AL Microbiome, 2014/01/01, Volume 2, p.36, (2014) Read More / View Supplemental Materials
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Joint modeling and registration of cell populations in cohorts of high-dimensional flow cytometric data.Pyne, S., Lee SX, Wang K., Irish J., Tamayo P., Nazaire MD, Duong T., Ng SK, Hafler D., Levy R., Nolan GP, Mesirov J., and McLachlan GJ PloS one, 2014/01/01, Volume 9, Issue 7, p.e100334, (2014) Read More / View Supplemental Materials
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Lack of evidence for a role of islet autoimmunity in the aetiology of canine diabetes mellitus.Ahlgren, KM, Fall T., Landegren N., Grimelius L., von Euler H., Sundberg K., Lindblad-Toh K., Lobell A., Hedhammar A., Andersson G., Hansson-Hamlin H., Lernmark A., and Kämpe O. PloS one, 2014/01/01, Volume 9, Issue 8, p.e105473, (2014) Read More / View Supplemental Materials
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Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.Tang, W., Kowgier M., Loth DW, Soler Artigas M., Joubert BR, Hodge E., Gharib SA, Smith AV, Ruczinski I., Gudnason V., Mathias RA, Harris TB, Hansel NN, Launer LJ, Barnes KC, Hansen JG, Albrecht E., Aldrich MC, Allerhand M., Barr RG, et al. PloS one, 2014/01/01, Volume 9, Issue 7, p.e100776, (2014) Read More / View Supplemental Materials
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Laser microdissection of the alveolar duct enables single-cell genomic analysis.Bennett, RD, Ysasi AB, Belle JM, Wagner WL, Konerding MA, Blainey PC, Pyne S., and Mentzer SJ Frontiers in oncology, 2014/01/01, Volume 4, p.260, (2014) Read More / View Supplemental Materials
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