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2011
A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin.Reiling, JH, Clish CB, Carette JE, Varadarajan M., Brummelkamp TR, and Sabatini DM Proceedings of the National Academy of Sciences of the United States of America, 2011/07/19, Volume 108, Issue 29, p.11756-65, (2011) Read More / View Supplemental Materials
Abstract
Humanized mice with ectopic artificial liver tissues.Chen, AA, Thomas DK, Ong LL, Schwartz RE, Golub T. R., and Bhatia SN Proceedings of the National Academy of Sciences of the United States of America, 2011/07/19, Volume 108, Issue 29, p.11842-7, (2011) Read More / View Supplemental Materials
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A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.Kemp, MM, Wang Q., Fuller JH, West N., Martinez NM, Morse EM, Weïwer M., Schreiber SL, Bradner JE, and Koehler AN Bioorganic & medicinal chemistry letters, 2011/07/15, Volume 21, Issue 14, p.4164-9, (2011) Read More / View Supplemental Materials
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Selective killing of cancer cells by a small molecule targeting the stress response to ROS.Raj, L., Ide T., Gurkar AU, Foley M., Schenone M., Li X., Tolliday NJ, Golub T. R., Carr SA, Shamji AF, Stern AM, Mandinova A., Schreiber SL, and Lee SW Nature, 2011/07/13, Volume 475, Issue 7355, p.231-4, (2011) Read More / View Supplemental Materials
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Catalytic Diastereoselective Petasis Reactions.Muncipinto, G., Moquist PN, Schreiber SL, and Schaus SE Angewandte Chemie (International ed. in English), 2011/07/12, (2011) Read More / View Supplemental Materials
QnAs with Eric S. Lander. Interview by Prashant Nair.Lander, E. S. Proceedings of the National Academy of Sciences of the United States of America, 2011/07/12, Volume 108, Issue 28, p.11319, (2011) Read More / View Supplemental Materials
Application of a sparse matrix design strategy to the synthesis of dos libraries.Akella, LB, and Marcaurelle LA ACS combinatorial science, 2011/07/11, Volume 13, Issue 4, p.357-64, (2011) Read More / View Supplemental Materials
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Synthesis of a stereochemically diverse library of medium-sized lactams and sultams via S(N)Ar cycloetherification.Gerard, B., Duvall JR, Lowe JT, Murillo T., Wei J., Akella LB, and Marcaurelle LA ACS combinatorial science, 2011/07/11, Volume 13, Issue 4, p.365-74, (2011) Read More / View Supplemental Materials
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Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia.Duong, V., Simmons C., Gavotte L., Viari A., Ong S., Chantha N., Lennon NJ, Birren BW, Vong S., Farrar JJ, Henn MR, Deubel V., Frutos R., and Buchy P. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2011/07/02, (2011) Read More / View Supplemental Materials
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Comparative genomics yields insights into niche adaptation of plant vascular wilt pathogens.Klosterman, SJ, Subbarao KV, Kang S., Veronese P., Gold SE, Thomma BP, Chen Z., Henrissat B., Lee YH, Park J., Garcia-Pedrajas MD, Barbara DJ, Anchieta A., de Jonge R., Santhanam P., Maruthachalam K., Atallah Z., Amyotte SG, Paz Z., Inderbitzin P., et al. PLoS pathogens, 2011/07/01, Volume 7, Issue 7, p.e1002137, (2011) Read More / View Supplemental Materials
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A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like.Kelly, TJ, Souza AL, Clish CB, and Puigserver P. Molecular and cellular biology, 2011/07/01, Volume 31, Issue 13, p.2696-706, (2011) Read More / View Supplemental Materials
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Points of view: Avoiding color.Wong, B. Nature methods, 2011/07/01, Volume 8, Issue 7, p.525, (2011) Read More / View Supplemental Materials
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.Fancy, SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C., Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R., Franklin RJ, and Rowitch DH Nature neuroscience, 2011/06/26, Volume 14, Issue 8, p.1009-16, (2011) Read More / View Supplemental Materials
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A public genome-scale lentiviral expression library of human ORFs.Yang, X., Boehm JS, Yang X., Salehi-Ashtiani K., Hao T., Shen Y., Lubonja R., Thomas SR, Alkan O., Bhimdi T., Green TM, Johannessen CM, Silver SJ, Nguyen C., Murray RR, Hieronymus H., Balcha D., Fan C., Lin C., Ghamsari L., et al. Nature methods, 2011/06/26, Volume 8, Issue 8, p.659-61, (2011) Read More / View Supplemental Materials
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Metagenomic biomarker discovery and explanation.Segata, N., Izard J., Waldron L., Gevers D., Miropolsky L., Garrett WS, and Huttenhower C. Genome biology, 2011/06/24, Volume 12, Issue 6, p.R60, (2011) Read More / View Supplemental Materials
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Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.Wang, Y., Jimenez M., Hansen AS, Raiber EA, Schreiber SL, and Young DW Journal of the American Chemical Society, 2011/06/22, Volume 133, Issue 24, p.9196-9, (2011) Read More / View Supplemental Materials
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A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.Luo, X., Liu Y., Kubicek S., Myllyharju J., Tumber A., Ng S., Che KH, Podoll J., Heightman TD, Oppermann U., Schreiber SL, and Wang X. Journal of the American Chemical Society, 2011/06/22, Volume 133, Issue 24, p.9451-6, (2011) Read More / View Supplemental Materials
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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.Baughman, JM, Perocchi F., Girgis HS, Plovanich M., Belcher-Timme CA, Sancak Y., Bao XR, Strittmatter L., Goldberger O., Bogorad RL, Koteliansky V., and Mootha VK Nature, 2011/06/19, Volume 476, Issue 7360, p.341-5, (2011) Read More / View Supplemental Materials
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A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease.Addona, TA, Shi X., Keshishian H., Mani D. R., Burgess M., Gillette MA, Clauser KR, Shen D., Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, and Carr SA Nature biotechnology, 2011/06/19, Volume 29, Issue 7, p.635-43, (2011) Read More / View Supplemental Materials
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Towards systematic functional characterization of cancer genomes.Boehm, JS, and Hahn WC Nature reviews. Genetics, 2011/06/17, Volume 12, Issue 7, p.487-98, (2011) Read More / View Supplemental Materials
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Genetics and pathogenesis of inflammatory bowel disease.Khor, B., Gardet A., and Xavier RJ Nature, 2011/06/15, Volume 474, Issue 7351, p.307-17, (2011) Read More / View Supplemental Materials
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Molecular signatures database (MSigDB) 3.0.Liberzon, A., Subramanian A., Pinchback R., Thorvaldsdóttir H., Tamayo P., and Mesirov J. P. Bioinformatics (Oxford, England), 2011/06/15, Volume 27, Issue 12, p.1739-40, (2011) Read More / View Supplemental Materials
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mRNA expression signature of Gleason grade predicts lethal prostate cancer.Penney, KL, Sinnott JA, Fall K., Pawitan Y., Hoshida Y., Kraft P., Stark JR, Fiorentino M., Perner S., Finn S., Calza S., Flavin R., Freedman ML, Setlur S., Sesso HD, Andersson SO, Martin N., Kantoff PW, Johansson JE, Adami HO, et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/06/10, Volume 29, Issue 17, p.2391-6, (2011) Read More / View Supplemental Materials
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Syntheses of α-pyrones using gold-catalyzed coupling reactions.Luo, T., Dai M., Zheng SL, and Schreiber SL Organic letters, 2011/06/03, Volume 13, Issue 11, p.2834-6, (2011) Read More / View Supplemental Materials
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AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.Pan, JQ, Lewis MC, Ketterman JK, Clore EL, Riley M., Richards KR, Berry-Scott E., Liu X., Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, and Haggarty SJ Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011/06/01, Volume 36, Issue 7, p.1397-411, (2011) Read More / View Supplemental Materials
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Computational methods for transcriptome annotation and quantification using RNA-seq.Garber, M., Grabherr MG, Guttman M., and Trapnell C. Nature methods, 2011/06/01, Volume 8, Issue 6, p.469-77, (2011) Read More / View Supplemental Materials
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Endemic dengue associated with the co-circulation of multiple viral lineages and localized density-dependent transmission.Raghwani, J., Rambaut A., Holmes EC, Hang VT, Hien TT, Farrar J., Wills B., Lennon NJ, Birren BW, Henn MR, and Simmons CP PLoS pathogens, 2011/06/01, Volume 7, Issue 6, p.e1002064, (2011) Read More / View Supplemental Materials
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RNA-protein interactions in human health and disease.Khalil, AM, and Rinn JL Seminars in cell & developmental biology, 2011/06/01, Volume 22, Issue 4, p.359-65, (2011) Read More / View Supplemental Materials
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Summaries from the XVIII World Congress of Psychiatric Genetics, Athens, Greece, 3-7 October 2010.Bergen, SE, Balhara YP, Christoforou A., Cole J., Degenhardt F., Dempster E., Fatjó-Vilas M., Khedr Y., Lopez LM, Lysenko L., McGrath LM, Mühleisen TW, Neves FS, Nymberg C., Ozomaro U., Verweij KJ, Voineskos AN, Zai CC, O'Shea A., and DeLisi LE Psychiatric genetics, 2011/06/01, Volume 21, Issue 3, p.136-72, (2011) Read More / View Supplemental Materials
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Obligate biotrophy features unraveled by the genomic analysis of rust fungi.Duplessis, S., Cuomo CA, Lin YC, Aerts A., Tisserant E., Veneault-Fourrey C., Joly DL, Hacquard S., Amselem J., Cantarel BL, Chiu R., Coutinho PM, Feau N., Field M., Frey P., Gelhaye E., Goldberg J., Grabherr MG, Kodira CD, Kohler A., et al. Proceedings of the National Academy of Sciences of the United States of America, 2011/05/31, Volume 108, Issue 22, p.9166-71, (2011) Read More / View Supplemental Materials
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Full-length transcriptome assembly from RNA-Seq data without a reference genome.Grabherr, MG, Haas BJ, Yassour M., Levin JZ, Thompson DA, Amit I., Adiconis X., Fan L., Raychowdhury R., Zeng Q., Chen Z., Mauceli E., Hacohen N., Gnirke A., Rhind N., Di Palma F., Birren BW, Nusbaum C., Lindblad-Toh K., Friedman N., et al. Nature biotechnology, 2011/05/15, Volume 29, Issue 7, p.644-52, (2011) Read More / View Supplemental Materials
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Mapping and analysis of chromatin state dynamics in nine human cell types.Ernst, J., Kheradpour P., Mikkelsen TS, Shoresh N., Ward LD, Epstein CB, Zhang X., Wang L., Issner R., Coyne M., Ku M., Durham T., Kellis M., and Bernstein BE Nature, 2011/05/05, Volume 473, Issue 7345, p.43-9, (2011) Read More / View Supplemental Materials
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Discovery of histone deacetylase 8 selective inhibitors.Tang, W., Luo T., Greenberg EF, Bradner JE, and Schreiber SL Bioorganic & medicinal chemistry letters, 2011/05/01, Volume 21, Issue 9, p.2601-5, (2011) Read More / View Supplemental Materials
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Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis.Zella, GC, Hait EJ, Glavan T., Gevers D., Ward DV, Kitts CL, and Korzenik JR Inflammatory bowel diseases, 2011/05/01, Volume 17, Issue 5, p.1092-100, (2011) Read More / View Supplemental Materials
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A framework for variation discovery and genotyping using next-generation DNA sequencing data.DePristo, MA, Banks E., Poplin R., Garimella KV, Maguire JR, Hartl C., Philippakis AA, del Angel G., Rivas MA, Hanna M., McKenna A., Fennell TJ, Kernytsky AM, Sivachenko AY, Cibulskis K., Gabriel SB, Altshuler D., and Daly M. J. Nature genetics, 2011/05/01, Volume 43, Issue 5, p.491-8, (2011) Read More / View Supplemental Materials
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Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells.Rabani, M., Levin JZ, Fan L., Adiconis X., Raychowdhury R., Garber M., Gnirke A., Nusbaum C., Hacohen N., Friedman N., Amit I., and Regev A. Nature biotechnology, 2011/05/01, Volume 29, Issue 5, p.436-42, (2011) Read More / View Supplemental Materials
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Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications.Yilmaz, P., Kottmann R., Field D., Knight R., Cole JR, Amaral-Zettler L., Gilbert JA, Karsch-Mizrachi I., Johnston A., Cochrane G., Vaughan R., Hunter C., Park J., Morrison N., Rocca-Serra P., Sterk P., Arumugam M., Bailey M., Baumgartner L., Birren BW, et al. Nature biotechnology, 2011/05/01, Volume 29, Issue 5, p.415-20, (2011) Read More / View Supplemental Materials
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Points of view: the overview figure.Wong, B. Nature methods, 2011/05/01, Volume 8, Issue 5, p.365, (2011) Read More / View Supplemental Materials
Targeting mutant fibroblast growth factor receptors in cancer.Greulich, H., and Pollock PM Trends in molecular medicine, 2011/05/01, Volume 17, Issue 5, p.283-92, (2011) Read More / View Supplemental Materials
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Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles.Comer, E., Liu H., Joliton A., Clabaut A., Johnson C., Akella LB, and Marcaurelle LA Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6751-6, (2011) Read More / View Supplemental Materials
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Organic synthesis toward small-molecule probes and drugs.Schreiber, SL Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6699-702, (2011) Read More / View Supplemental Materials
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Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.Clemons, PA, Wilson JA, Dančík V., Muller S., Carrinski HA, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6817-22, (2011) Read More / View Supplemental Materials
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Route to three-dimensional fragments using diversity-oriented synthesis.Hung, AW, Ramek A., Wang Y., Kaya T., Wilson JA, Clemons PA, and Young DW Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6799-804, (2011) Read More / View Supplemental Materials
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Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software.Kamentsky, L., Jones TR, Fraser A., Bray MA, Logan DJ, Madden KL, Ljosa V., Rueden C., Eliceiri KW, and Carpenter AE Bioinformatics (Oxford, England), 2011/04/15, Volume 27, Issue 8, p.1179-80, (2011) Read More / View Supplemental Materials
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Improving SNP discovery by base alignment quality.Li, H. Bioinformatics (Oxford, England), 2011/04/15, Volume 27, Issue 8, p.1157-8, (2011) Read More / View Supplemental Materials
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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.Cho, YJ, Tsherniak A., Tamayo P., Santagata S., Ligon A., Greulich H., Berhoukim R., Amani V., Goumnerova L., Eberhart CG, Lau CC, Olson JM, Gilbertson RJ, Gajjar A., Delattre O., Kool M., Ligon K., Meyerson M., Mesirov J. P., and Pomeroy SL Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/04/10, Volume 29, Issue 11, p.1424-30, (2011) Read More / View Supplemental Materials
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Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features.Tamayo, P., Cho YJ, Tsherniak A., Greulich H., Ambrogio L., Schouten-van Meeteren N., Zhou T., Buxton A., Kool M., Meyerson M., Pomeroy SL, and Mesirov J. P. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/04/10, Volume 29, Issue 11, p.1415-23, (2011) Read More / View Supplemental Materials
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Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.Heath, RJ, Leong JM, Visegrády B., Machesky LM, and Xavier RJ PLoS pathogens, 2011/04/01, Volume 7, Issue 4, p.e1001332, (2011) Read More / View Supplemental Materials
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Evaluation of large scale quantitative proteomic assay development using peptide affinity-based mass spectrometry.Whiteaker, JR, Zhao L., Abbatiello SE, Burgess M., Kuhn E., Lin C., Pope ME, Razavi M., Anderson NL, Pearson TW, Carr SA, and Paulovich AG Molecular & cellular proteomics : MCP, 2011/04/01, Volume 10, Issue 4, p.M110.005645, (2011) Read More / View Supplemental Materials
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Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.Van Tyne, D., Park DJ, Schaffner SF, Neafsey DE, Angelino E., Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA Jr, Johnson CA, Shlyakhter I., Grossman SR, Becker JS, Yamins D., Karlsson EK, Ndiaye D., Sarr O., Mboup S., et al. PLoS genetics, 2011/04/01, Volume 7, Issue 4, p.e1001383, (2011) Read More / View Supplemental Materials
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Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.Rhee, EP, Cheng S., Larson MG, Walford GA, Lewis GD, McCabe E., Yang E., Farrell L., Fox CS, O'Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, and Gerszten RE The Journal of clinical investigation, 2011/04/01, Volume 121, Issue 4, p.1402-11, (2011) Read More / View Supplemental Materials
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Metabolite profiles and the risk of developing diabetes.Wang, TJ, Larson MG, Vasan RS, Cheng S., Rhee EP, McCabe E., Lewis GD, Fox CS, Jacques PF, Fernandez C., O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A., Melander O., Clish CB, and Gerszten RE Nature medicine, 2011/04/01, Volume 17, Issue 4, p.448-53, (2011) Read More / View Supplemental Materials
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Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling.Gu, H., Smith ZD, Bock C., Boyle P., Gnirke A., and Meissner A. Nature protocols, 2011/04/01, Volume 6, Issue 4, p.468-81, (2011) Read More / View Supplemental Materials
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Screening: Low-fat worms on drugs.Wagner, BK Nature chemical biology, 2011/04/01, Volume 7, Issue 4, p.194-5, (2011) Read More / View Supplemental Materials
Initial genome sequencing and analysis of multiple myeloma.Chapman, MA, Lawrence MS, Keats JJ, Cibulskis K., Sougnez C., Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M., Anderson KC, Ardlie KG, Auclair D., Baker A., Bergsagel PL, Bernstein BE, Drier Y., Fonseca R., Gabriel SB, Hofmeister CC, et al. Nature, 2011/03/24, Volume 471, Issue 7339, p.467-72, (2011) Read More / View Supplemental Materials
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Impulse control: temporal dynamics in gene transcription.Yosef, N., and Regev A. Cell, 2011/03/18, Volume 144, Issue 6, p.886-96, (2011) Read More / View Supplemental Materials
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Large-scale synthesis of all stereoisomers of a 2,3-unsaturated C-glycoside scaffold.Gerard, B., Marié JC, Pandya BA, Lee MD 4th, Liu H., and Marcaurelle LA The Journal of organic chemistry, 2011/03/18, Volume 76, Issue 6, p.1898-901, (2011) Read More / View Supplemental Materials
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SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.Souza, A., Zhang J., and Clish CB Cancer cell, 2011/03/08, Volume 19, Issue 3, p.416-28, (2011) Read More / View Supplemental Materials
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Chemoproteomics quantifies complexity.Holson, EB, and Schreiber SL Nature biotechnology, 2011/03/01, Volume 29, Issue 3, p.235-6, (2011) Read More / View Supplemental Materials
Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons.Haas, BJ, Gevers D., Earl AM, Feldgarden M., Ward DV, Giannoukos G., Ciulla D., Tabbaa D., Highlander SK, Sodergren E., Methé B., DeSantis TZ, Human Microbiome Consortium, Petrosino JF, Knight R., and Birren BW Genome research, 2011/03/01, Volume 21, Issue 3, p.494-504, (2011) Read More / View Supplemental Materials
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Points of view: Points of review (part 2).Wong, B. Nature methods, 2011/03/01, Volume 8, Issue 3, p.189, (2011) Read More / View Supplemental Materials
Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance.Kang, MS, Lee EK, Soni V., Lewis TA, Koehler AN, Srinivasan V., and Kieff E. Journal of virology, 2011/03/01, Volume 85, Issue 6, p.2859-68, (2011) Read More / View Supplemental Materials
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Tabix: fast retrieval of sequence features from generic TAB-delimited files.Li, H. Bioinformatics (Oxford, England), 2011/03/01, Volume 27, Issue 5, p.718-9, (2011) Read More / View Supplemental Materials
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Genome-sequencing anniversary. The accelerator.Lander, E. S. Science (New York, N.Y.), 2011/02/25, Volume 331, Issue 6020, p.1024, (2011) Read More / View Supplemental Materials
Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.Green, MR, Monti S., Dalla-Favera R., Pasqualucci L., Walsh NC, Schmidt-Supprian M., Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K., Golub T. R., Alt F. W., Shipp M. A., and Manis J. P. Proceedings of the National Academy of Sciences of the United States of America, 2011/02/15, Volume 108, Issue 7, p.2873-8, (2011) Read More / View Supplemental Materials
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Visual representation of scientific information.Wong, B. Science signaling, 2011/02/15, Volume 4, Issue 160, p.pt1, (2011) Read More / View Supplemental Materials
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The genomic complexity of primary human prostate cancer.Berger, MF, Lawrence MS, Demichelis F., Drier Y., Cibulskis K., Sivachenko AY, Sboner A., Esgueva R., Pflueger D., Sougnez C., Onofrio R., Carter SL, Park K., Habegger L., Ambrogio L., Fennell T., Parkin M., Saksena G., Voet D., Ramos AH, et al. Nature, 2011/02/10, Volume 470, Issue 7333, p.214-20, (2011) Read More / View Supplemental Materials
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Initial impact of the sequencing of the human genome.Lander, E. S. Nature, 2011/02/10, Volume 470, Issue 7333, p.187-97, (2011) Read More / View Supplemental Materials
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SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.Ding, Z., Wu CJ, Chu GC, Xiao Y., Ho D., Zhang J., Perry SR, Labrot ES, Wu X., Lis R., Hoshida Y., Hiller D., Hu B., Jiang S., Zheng H., Stegh AH, Scott KL, Signoretti S., Bardeesy N., Wang YA, et al. Nature, 2011/02/10, Volume 470, Issue 7333, p.269-73, (2011) Read More / View Supplemental Materials
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Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate.Proia, TA, Keller PJ, Gupta PB, Klebba I., Jones AD, Sedic M., Gilmore H., Tung N., Naber SP, Schnitt S., Lander E. S., and Kuperwasser C. Cell stem cell, 2011/02/04, Volume 8, Issue 2, p.149-63, (2011) Read More / View Supplemental Materials
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Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.Bock, C., Kiskinis E., Verstappen G., Gu H., Boulting G., Smith ZD, Ziller M., Croft GF, Amoroso MW, Oakley DH, Gnirke A., Eggan K., and Meissner A. Cell, 2011/02/04, Volume 144, Issue 3, p.439-52, (2011) Read More / View Supplemental Materials
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Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.Elkabets, M., Gifford AM, Scheel C., Nilsson B., Reinhardt F., Bray MA, Carpenter AE, Jirström K., Magnusson K., Ebert BL, Pontén F., Weinberg R. A., and McAllister SS The Journal of clinical investigation, 2011/02/01, Volume 121, Issue 2, p.784-99, (2011) Read More / View Supplemental Materials
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Points of review (part 1).Wong, B. Nature methods, 2011/02/01, Volume 8, Issue 2, p.101, (2011) Read More / View Supplemental Materials
Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.Gomez, JE, Clatworthy A., and Hung DT Critical reviews in biochemistry and molecular biology, 2011/02/01, Volume 46, Issue 1, p.41-66, (2011) Read More / View Supplemental Materials
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High-quality draft assemblies of mammalian genomes from massively parallel sequence data.Gnerre, S., Maccallum I., Przybylski D., Ribeiro FJ, Burton JN, Walker BJ, Sharpe T., Hall G., Shea TP, Sykes S., Berlin AM, Aird D., Costello M., Daza R., Williams L., Nicol R., Gnirke A., Nusbaum C., Lander E. S., and Jaffe DB Proceedings of the National Academy of Sciences of the United States of America, 2011/01/25, Volume 108, Issue 4, p.1513-8, (2011) Read More / View Supplemental Materials
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MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13.Sankaran, VG, Menne TF, Šćepanović D., Vergilio JA, Ji P., Kim J., Thiru P., Orkin SH, Lander E. S., and Lodish HF Proceedings of the National Academy of Sciences of the United States of America, 2011/01/25, Volume 108, Issue 4, p.1519-24, (2011) Read More / View Supplemental Materials
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Densely interconnected transcriptional circuits control cell states in human hematopoiesis.Novershtern, N., Subramanian A., Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N., Yosef N., Chang CY, Shay T., Frampton GM, Drake AC, Leskov I., Nilsson B., Preffer F., Dombkowski D., Evans JW, Liefeld T., Smutko JS, Chen J., et al. Cell, 2011/01/21, Volume 144, Issue 2, p.296-309, (2011) Read More / View Supplemental Materials
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Next-generation sequencing for HLA typing of class I loci.Erlich, RL, Jia X., Anderson S., Banks E., Gao X., Carrington M., Gupta N., DePristo MA, Henn MR, Lennon NJ, and de Bakker PI BMC genomics, 2011/01/18, Volume 12, p.42, (2011) Read More / View Supplemental Materials
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PriSM: a primer selection and matching tool for amplification and sequencing of viral genomes.Yu, Q., Ryan EM, Allen TM, Birren BW, Henn MR, and Lennon NJ Bioinformatics (Oxford, England), 2011/01/15, Volume 27, Issue 2, p.266-7, (2011) Read More / View Supplemental Materials
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Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.Rossin, EJ, Lage K., Raychaudhuri S., Xavier RJ, Tatar D., Benita Y., International Inflammatory Bowel Disease Genetics Constortium, Cotsapas C., and Daly M. J. PLoS genetics, 2011/01/13, Volume 7, Issue 1, p.e1001273, (2011) Read More / View Supplemental Materials
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Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes.Shaw, SY, Blodgett DM, Ma MS, Westly EC, Clemons PA, Subramanian A., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2011/01/11, Volume 108, Issue 2, p.492-7, (2011) Read More / View Supplemental Materials
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Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records.Kurreeman, F., Liao K., Chibnik L., Hickey B., Stahl E., Gainer V., Li G., Bry L., Mahan S., Ardlie K., Thomson B., Szolovits P., Churchill S., Murphy SN, Cai T., Raychaudhuri S., Kohane I., Karlson E., and Plenge RM American journal of human genetics, 2011/01/07, Volume 88, Issue 1, p.57-69, (2011) Read More / View Supplemental Materials
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Reprogramming factor expression initiates widespread targeted chromatin remodeling.Koche, RP, Smith ZD, Adli M., Gu H., Ku M., Gnirke A., Bernstein BE, and Meissner A. Cell stem cell, 2011/01/07, Volume 8, Issue 1, p.96-105, (2011) Read More / View Supplemental Materials
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Endurance, refuge, and reemergence of dengue virus type 2, Puerto Rico, 1986-2007.McElroy, KL, Santiago GA, Lennon NJ, Birren BW, Henn MR, and Muñoz-Jordán JL Emerging infectious diseases, 2011/01/01, Volume 17, Issue 1, p.64-71, (2011) Read More / View Supplemental Materials
Abstract
Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer.Dutt, A., Ramos AH, Hammerman PS, Mermel C., Cho J., Sharifnia T., Chande A., Tanaka KE, Stransky N., Greulich H., Gray NS, and Meyerson M. PloS one, 2011/01/01, Volume 6, Issue 6, p.e20351, (2011) Read More / View Supplemental Materials
Abstract
Integrative genomics viewer.Robinson, JT, Thorvaldsdóttir H., Winckler W., Guttman M., Lander E. S., Getz G., and Mesirov J. P. Nature biotechnology, 2011/01/01, Volume 29, Issue 1, p.24-6, (2011) Read More / View Supplemental Materials
Reducing the Effects of PCR Amplification and Sequencing Artifacts on 16S rRNA-Based Studies.Schloss, PD, Gevers D., and Westcott SL PloS one, 2011/01/01, Volume 6, Issue 12, p.e27310, (2011) Read More / View Supplemental Materials
Abstract
2010
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.Johannessen, CM, Boehm JS, Kim SY, Thomas SR, Wardwell L., Johnson LA, Emery CM, Stransky N., Cogdill AP, Barretina J., Caponigro G., Hieronymus H., Murray RR, Salehi-Ashtiani K., Hill DE, Vidal M., Zhao JJ, Yang X., Alkan O., Kim S., et al. Nature, 2010/12/16, Volume 468, Issue 7326, p.968-72, (2010) Read More / View Supplemental Materials
Abstract
Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling.Fillmore, CM, Gupta PB, Rudnick JA, Caballero S., Keller PJ, Lander E. S., and Kuperwasser C. Proceedings of the National Academy of Sciences of the United States of America, 2010/12/14, Volume 107, Issue 50, p.21737-42, (2010) Read More / View Supplemental Materials
Abstract
An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.Marcaurelle, LA, Comer E., Dandapani S., Duvall JR, Gerard B., Kesavan S., Lee MD 4th, Liu H., Lowe JT, Marie JC, Mulrooney CA, Pandya BA, Rowley A., Ryba TD, Suh BC, Wei J., Young DW, Akella LB, Ross NT, Zhang YL, et al. Journal of the American Chemical Society, 2010/12/01, Volume 132, Issue 47, p.16962-76, (2010) Read More / View Supplemental Materials
Abstract
The early whole-blood transcriptional signature of dengue virus and features associated with progression to dengue shock syndrome in Vietnamese children and young adults.Hoang, LT, Lynn DJ, Henn M., Birren BW, Lennon NJ, Le PT, Duong KT, Nguyen TT, Mai LN, Farrar JJ, Hibberd ML, and Simmons CP Journal of virology, 2010/12/01, Volume 84, Issue 24, p.12982-94, (2010) Read More / View Supplemental Materials
Abstract
The genomics of lung adenocarcinoma: opportunities for targeted therapies.Greulich, H. Genes & cancer, 2010/12/01, Volume 1, Issue 12, p.1200-10, (2010) Read More / View Supplemental Materials
Abstract
Grand challenge commentary: Accessing new chemical space for 'undruggable' targets.Dandapani, S., and Marcaurelle LA Nature chemical biology, 2010/12/01, Volume 6, Issue 12, p.861-3, (2010) Read More / View Supplemental Materials
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Grand challenge commentary: Chemical transdifferentiation and regenerative medicine.Wagner, BK Nature chemical biology, 2010/12/01, Volume 6, Issue 12, p.877-9, (2010) Read More / View Supplemental Materials
Abstract
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.Loewer, S., Cabili MN, Guttman M., Loh YH, Thomas K., Park IH, Garber M., Curran M., Onder T., Agarwal S., Manos PD, Datta S., Lander E. S., Schlaeger TM, Daley GQ, and Rinn JL Nature genetics, 2010/12/01, Volume 42, Issue 12, p.1113-7, (2010) Read More / View Supplemental Materials
Abstract
Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity.Chen, J., Armstrong AH, Koehler AN, and Hecht MH Journal of the American Chemical Society, 2010/12/01, Volume 132, Issue 47, p.17015-22, (2010) Read More / View Supplemental Materials
Abstract
Nearest template prediction: a single-sample-based flexible class prediction with confidence assessment.Hoshida, Y. PloS one, 2010/11/23, Volume 5, Issue 11, p.e15543, (2010) Read More / View Supplemental Materials
Abstract
Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions.Muncipinto, G., Kaya T., Wilson JA, Kumagai N., Clemons PA, and Schreiber SL Organic letters, 2010/11/19, Volume 12, Issue 22, p.5230-3, (2010) Read More / View Supplemental Materials
Abstract
Personalized medicine in rheumatoid arthritis: Miles to go before we sleep.Plenge, RM, and Bridges SL Jr Arthritis and rheumatism, 2010/11/04, (2010) Read More / View Supplemental Materials
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.Clemons, PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2010/11/02, Volume 107, Issue 44, p.18787-92, (2010) Read More / View Supplemental Materials
Abstract