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2014
Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters.Naba, A., Clauser KR, Lamar JM, Carr SA, and Hynes R. O. eLife, 2014/03/11, Volume 3, p.e01308, (2014) Read More / View Supplemental Materials
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In Vivo and in vitro dynamics of undifferentiated embryonic cell transcription factor 1.Galonska, C., Smith ZD, and Meissner A. Stem cell reports, 2014/03/11, Volume 2, Issue 3, p.245-52, (2014) Read More / View Supplemental Materials
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Common genetic variants modulate pathogen-sensing responses in human dendritic cells.Lee, MN, Ye C., Villani AC, Raj T., Li W., Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K., Ward LD, Raddassi K., McCabe C., Lee MH, Frohlich IY, Hafler DA, Kellis M., Raychaudhuri S., Zhang F., Stranger BE, et al. Science (New York, N.Y.), 2014/03/07, Volume 343, Issue 6175, p.1246980, (2014) Read More / View Supplemental Materials
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2013 Victor A. McKusick Leadership Award Introduction: Kurt and Rochelle Hirschhorn.Hirschhorn, JN American journal of human genetics, 2014/03/06, Volume 94, Issue 3, p.334-5, (2014) Read More / View Supplemental Materials
Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer.Mihaylova, MM, Sabatini DM, and Yilmaz OH Cell stem cell, 2014/03/06, Volume 14, Issue 3, p.292-305, (2014) Read More / View Supplemental Materials
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An excess of risk-increasing low-frequency variants can be a signal of polygenic inheritance in complex diseases.Chan, Y., Lim ET, Sandholm N., Wang SR, McKnight AJ, Ripke S., DIAGRAM Consortium, GENIE Consortium, GIANT Consortium, IIBDGC Consortium, PGC Consortium, Daly M. J., Neale BM, Salem RM, and Hirschhorn JN American journal of human genetics, 2014/03/06, Volume 94, Issue 3, p.437-52, (2014) Read More / View Supplemental Materials
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Functional and phylogenetic assembly of microbial communities in the human microbiome.Shafquat, A., Joice R., Simmons SL, and Huttenhower C. Trends in microbiology, 2014/03/04, (2014) Read More / View Supplemental Materials
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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.Knoechel, B., Roderick JE, Williamson KE, Zhu J., Lohr JG, Cotton MJ, Gillespie SM, Fernandez D., Ku M., Wang H., Piccioni F., Silver SJ, Jain M., Pearson D., Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A., et al. Nature genetics, 2014/03/02, (2014) Read More / View Supplemental Materials
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The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells.Kurachi, M., Barnitz RA, Yosef N., Odorizzi PM, Diiorio MA, Lemieux ME, Yates K., Godec J., Klatt MG, Regev A., Wherry EJ, and Haining WN Nature immunology, 2014/03/02, (2014) Read More / View Supplemental Materials
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A121: in search of infectious triggers of periodic Fever, aphthous stomatitis, pharyngitis and adenitis syndrome.Freeman, S., Bhatt A., Pedamallu C., King S., Duke F., Jung J., Lawton M., Anderson E., Fuhlbrigge RC, Kenna M., Licameli G., Meyerson M., and Dedeoglu F. Arthritis & rheumatology (Hoboken, N.J.), 2014/03/01, Volume 66 Suppl 11, p.S158, (2014) Read More / View Supplemental Materials
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ARID1B is a specific vulnerability in ARID1A-mutant cancers.Helming, KC, Wang X., Wilson BG, Vazquez F., Haswell JR, Manchester HE, Kim Y., Kryukov GV, Ghandi M., Aguirre AJ, Jagani Z., Wang Z., Garraway LA, Hahn WC, and Roberts CW Nature medicine, 2014/03/01, Volume 20, Issue 3, p.251-4, (2014) Read More / View Supplemental Materials
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Genetic Dissection of Anopheles gambiae Gut Epithelial Responses to Serratia marcescens.Stathopoulos, S., Neafsey DE, Lawniczak MK, Muskavitch MA, and Christophides GK PLoS pathogens, 2014/03/01, Volume 10, Issue 3, p.e1003897, (2014) Read More / View Supplemental Materials
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Lassa Fever in post-conflict sierra leone.Shaffer, JG, Grant DS, Schieffelin JS, Boisen ML, Goba A., Hartnett JN, Levy DC, Yenni RE, Moses LM, Fullah M., Momoh M., Fonnie M., Fonnie R., Kanneh L., Koroma VJ, Kargbo K., Ottomassathien D., Muncy IJ, Jones AB, Illick MM, et al. PLoS neglected tropical diseases, 2014/03/01, Volume 8, Issue 3, p.e2748, (2014) Read More / View Supplemental Materials
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Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation.Wilson, BG, Helming KC, Wang X., Kim Y., Vazquez F., Jagani Z., Hahn WC, and Roberts CW Molecular and cellular biology, 2014/03/01, Volume 34, Issue 6, p.1136-44, (2014) Read More / View Supplemental Materials
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Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach.Carr, SA, Abbatiello SE, Ackermann BL, Borchers C., Domon B., Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R., Koomen JM, Liebler DC, Liu T., Maclean B., Mani D., Mansfield E., Neubert H., Paulovich AG, Reiter L., Vitek O., Aebersold R., et al. Molecular & cellular proteomics : MCP, 2014/03/01, Volume 13, Issue 3, p.907-17, (2014) Read More / View Supplemental Materials
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Understanding Th17 cells through systematic genomic analyses.Peters, A., and Yosef N. Current opinion in immunology, 2014/03/01, Volume 28C, p.42-48, (2014) Read More / View Supplemental Materials
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Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue.Shi, J., Marconett CN, Duan J., Hyland PL, Li P., Wang Z., Wheeler W., Zhou B., Campan M., Lee DS, Huang J., Zhou W., Triche T., Amundadottir L., Warner A., Hutchinson A., Chen PH, Chung BS, Pesatori AC, Consonni D., et al. Nature communications, 2014/02/27, Volume 5, p.3365, (2014) Read More / View Supplemental Materials
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Crystal structure of cas9 in complex with guide RNA and target DNA.Nishimasu, H., Ran FA, Hsu PD, Konermann S., Shehata SI, Dohmae N., Ishitani R., Zhang F., and Nureki O. Cell, 2014/02/27, Volume 156, Issue 5, p.935-49, (2014) Read More / View Supplemental Materials
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Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2.Huang, J., Huffman JE, Yamkauchi M., Trompet S., Asselbergs FW, Sabater-Lleal M., Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W., Dehghan A., Johnson AD, Truong V., Folkersen L., Yang Q., Oudot-Mellkah T., Buckley BM, et al. Arteriosclerosis, thrombosis, and vascular biology, 2014/02/27, (2014) Read More / View Supplemental Materials
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Genome-Wide Genotyping Demonstrates a Polygenic Risk Score Associated With White Matter Hyperintensity Volume in CADASIL.Opherk, C., Gonik M., Duering M., Malik R., Jouvent E., Hervé D., Adib-Samii P., Bevan S., Pianese L., Silvestri S., Dotti MT, De Stefano N., Liem M., Boon EM, Pescini F., Pachai C., Bracoud L., Müller-Myhsok B., Meitinger T., Rost N., et al. Stroke; a journal of cerebral circulation, 2014/02/27, (2014) Read More / View Supplemental Materials
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Detection and replication of epistasis influencing transcription in humans.Hemani, G., Shakhbazov K., Westra HJ, Esko T., Henders AK, McRae AF, Yang J., Gibson G., Martin NG, Metspalu A., Franke L., Montgomery GW, Visscher PM, and Powell JE Nature, 2014/02/26, (2014) Read More / View Supplemental Materials
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Prostaglandin E2 Regulates Liver versus Pancreas Cell-Fate Decisions and Endodermal Outgrowth.Nissim, S., Sherwood RI, Wucherpfennig J., Saunders D., Harris JM, Esain V., Carroll KJ, Frechette GM, Kim AJ, Hwang KL, Cutting CC, Elledge S., North TE, and Goessling W. Developmental cell, 2014/02/24, Volume 28, Issue 4, p.423-37, (2014) Read More / View Supplemental Materials
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Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci.Tragante, V., Barnes MR, Ganesh SK, Lanktree MB, Guo W., Franceschini N., Smith EN, Johnson T., Holmes MV, Padmanabhan S., Karczewski KJ, Almoguera B., Barnard J., Baumert J., Chang YP, Elbers CC, Farrall M., Fischer ME, Gaunt TR, Gho JM, et al. American journal of human genetics, 2014/02/19, (2014) Read More / View Supplemental Materials
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The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.Kostic, AD, Xavier RJ, and Gevers D. Gastroenterology, 2014/02/18, (2014) Read More / View Supplemental Materials
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Genetic Association Analysis of 300 Genes Identifies a Risk Haplotype in SLC18A2 for Posttraumatic Stress Disorder in two Independent Samples.Solovieff, N., Roberts AL, Ratanatharathorn A., Haloosim M., De Vivo I., King AP, Liberzon I., Aiello A., Uddin M., Wildman DE, Galea S., Smoller JW, Purcell SM, and Koenen KC Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014/02/14, (2014) Read More / View Supplemental Materials
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Targeting the pancreatic β-cell to treat diabetes.Vetere, A., Choudhary A., Burns SM, and Wagner BK Nature reviews. Drug discovery, 2014/02/14, (2014) Read More / View Supplemental Materials
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De novo mutations in schizophrenia implicate synaptic networks.Fromer, M., Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S., Gormley P., Georgieva L., Rees E., Palta P., Ruderfer DM, Carrera N., Humphreys I., Johnson JS, Roussos P., Barker DD, Banks E., Milanova V., Grant SG, Hannon E., Rose SA, et al. Nature, 2014/02/13, Volume 506, Issue 7487, p.179-84, (2014) Read More / View Supplemental Materials
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Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.Dandapani, S., Germain AR, Jewett I., le Quement S., Marie JC, Muncipinto G., Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J., Kellar D., Siqueira-Neto JL, McKerrow JH, Kaiser M., Rodriguez A., Palmer MA, Foley M., Schreiber SL, and Munoz B. ACS medicinal chemistry letters, 2014/02/13, Volume 5, Issue 2, p.149-53, (2014) Read More / View Supplemental Materials
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Early Empiric Antibiotic Use in Preterm Infants Is Associated with Lower Bacterial Diversity and Higher Relative Abundance of Enterobacter.Greenwood, C., Morrow AL, Lagomarcino AJ, Altaye M., Taft DH, Yu Z., Newburg DS, Ward DV, and Schibler KR The Journal of pediatrics, 2014/02/13, (2014) Read More / View Supplemental Materials
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A polygenic burden of rare disruptive mutations in schizophrenia.Purcell, SM, Moran JL, Fromer M., Ruderfer D., Solovieff N., Roussos P., O'Dushlaine C., Chambert K., Bergen SE, Kähler A., Duncan L., Stahl E., Genovese G., Fernández E., Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E., Shakir K., et al. Nature, 2014/02/13, Volume 506, Issue 7487, p.185-90, (2014) Read More / View Supplemental Materials
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Zebrafish models of cerebrovascular disease.Walcott, BP, and Peterson RT Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014/02/12, (2014) Read More / View Supplemental Materials
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Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu.Leitsalu, L., Haller T., Esko T., Tammesoo ML, Alavere H., Snieder H., Perola M., Ng PC, Mägi R., Milani L., Fischer K., and Metspalu A. International journal of epidemiology, 2014/02/11, (2014) Read More / View Supplemental Materials
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Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization.Gorden, BH, Kim JH, Sarver AL, Frantz AM, Breen M., Lindblad-Toh K., O'Brien TD, Sharkey LC, Modiano JF, and Dickerson EB The American journal of pathology, 2014/02/11, (2014) Read More / View Supplemental Materials
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Nanog-Independent Reprogramming to iPSCs with Canonical Factors.Carter, AC, Davis-Dusenbery BN, Koszka K., Ichida JK, and Eggan K. Stem cell reports, 2014/02/11, Volume 2, Issue 2, p.119-26, (2014) Read More / View Supplemental Materials
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Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).Chhibber, A., Mefford J., Stahl EA, Pendergrass SA, Baldwin RM, Owzar K., Li M., Winer EP, Hudis CA, Zembutsu H., Kubo M., Nakamura Y., McLeod HL, Ratain MJ, Shulman LN, Ritchie MD, Plenge RM, Witte JS, and Kroetz DL The pharmacogenomics journal, 2014/02/11, (2014) Read More / View Supplemental Materials
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SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia.Puissant, A., Fenouille N., Alexe G., Pikman Y., Bassil CF, Mehta S., Du J., Kazi JU, Luciano F., Rönnstrand L., Kung AL, Aster J. C., Galinsky I., Stone RM, DeAngelo DJ, Hemann MT, and Stegmaier K. Cancer cell, 2014/02/10, Volume 25, Issue 2, p.226-42, (2014) Read More / View Supplemental Materials
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The antidepressant age.Hyman, SE Nature medicine, 2014/02/06, Volume 20, Issue 2, p.118-9, (2014) Read More / View Supplemental Materials
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.Peloso, GM, Auer PL, Bis JC, Voorman A., Morrison AC, Stitziel NO, Brody JA, Khetarpal SA, Crosby JR, Fornage M., Isaacs A., Jakobsdottir J., Feitosa MF, Davies G., Huffman JE, Manichaikul A., Davis B., Lohman K., Joon AY, Smith AV, et al. American journal of human genetics, 2014/02/06, Volume 94, Issue 2, p.223-32, (2014) Read More / View Supplemental Materials
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Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease.Bennett, DA, Yu L., and De Jager PL Biochemical pharmacology, 2014/02/06, (2014) Read More / View Supplemental Materials
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Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission.Rooks, MG, Veiga P., Wardwell-Scott LH, Tickle T., Segata N., Michaud M., Gallini CA, Beal C., van Hylckama-Vlieg JE, Ballal SA, Morgan XC, Glickman JN, Gevers D., Huttenhower C., and Garrett WS The ISME journal, 2014/02/06, (2014) Read More / View Supplemental Materials
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In vivo discovery of immunotherapy targets in the tumour microenvironment.Zhou, P., Shaffer DR, Alvarez Arias DA, Nakazaki Y., Pos W., Torres AJ, Cremasco V., Dougan SK, Cowley GS, Elpek K., Brogdon J., Lamb J., Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G., Hacohen N., Cantor H., and Wucherpfennig KW Nature, 2014/02/06, Volume 506, Issue 7486, p.52-7, (2014) Read More / View Supplemental Materials
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Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol.Lange, LA, Hu Y., Zhang H., Xue C., Schmidt EM, Tang ZZ, Bizon C., Lange EM, Smith JD, Turner EH, Jun G., Kang HM, Peloso G., Auer P., Li KP, Flannick J., Zhang J., Fuchsberger C., Gaulton K., Lindgren C., et al. American journal of human genetics, 2014/02/06, Volume 94, Issue 2, p.233-45, (2014) Read More / View Supplemental Materials
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Genetic variation of oxidative phosphorylation genes in stroke and Alzheimer's disease.Biffi, A., Sabuncu MR, Desikan RS, Schmansky N., Salat DH, Rosand J., Anderson CD, and Alzheimer's disease Neuroimaging Initiative(ADNI) Neurobiology of aging, 2014/02/05, (2014) Read More / View Supplemental Materials
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Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model.Zhao, T., Li Y., Liu B., Halaweish I., Mazitschek R., and Alam HB The Journal of surgical research, 2014/02/04, (2014) Read More / View Supplemental Materials
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Extracting data from the muck: deriving biological insight from complex microbial communities and non-model organisms with next generation sequencing.Solomon, KV, Haitjema CH, Thompson DA, and O'Malley MA Current opinion in biotechnology, 2014/02/03, Volume 28C, p.103-110, (2014) Read More / View Supplemental Materials
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Advantages and pitfalls in the application of mixed-model association methods.Yang, J., Zaitlen NA, Goddard ME, Visscher PM, and Price AL Nature genetics, 2014/02/01, Volume 46, Issue 2, p.100-6, (2014) Read More / View Supplemental Materials
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Analysis of copy number variations at 15 schizophrenia-associated loci.Rees, E., Walters JT, Georgieva L., Isles AR, Chambert KD, Richards AL, Mahoney-Davies G., Legge SE, Moran JL, McCarroll SA, O'Donovan MC, Owen MJ, and Kirov G. The British journal of psychiatry : the journal of mental science, 2014/02/01, Volume 204, Issue 2, p.108-14, (2014) Read More / View Supplemental Materials
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Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons.Fischer, K., Kettunen J., Würtz P., Haller T., Havulinna AS, Kangas AJ, Soininen P., Esko T., Tammesoo ML, Mägi R., Smit S., Palotie A., Ripatti S., Salomaa V., Ala-Korpela M., Perola M., and Metspalu A. PLoS medicine, 2014/02/01, Volume 11, Issue 2, p.e1001606, (2014) Read More / View Supplemental Materials
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Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24.Agler, C., Nielsen DM, Urkasemsin G., Singleton A., Tonomura N., Sigurdsson S., Tang R., Linder K., Arepalli S., Hernandez D., Lindblad-Toh K., van de Leemput J., Motsinger-Reif A., O'Brien DP, Bell J., Harris T., Steinberg S., and Olby NJ PLoS genetics, 2014/02/01, Volume 10, Issue 2, p.e1003991, (2014) Read More / View Supplemental Materials
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Chromosome x-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.Tukiainen, T., Pirinen M., Sarin AP, Ladenvall C., Kettunen J., Lehtimäki T., Lokki ML, Perola M., Sinisalo J., Vlachopoulou E., Eriksson JG, Groop L., Jula A., Järvelin MR, Raitakari OT, Salomaa V., and Ripatti S. PLoS genetics, 2014/02/01, Volume 10, Issue 2, p.e1004127, (2014) Read More / View Supplemental Materials
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Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins.Kennedy, JJ, Abbatiello SE, Kim K., Yan P., Whiteaker JR, Lin C., Kim JS, Zhang Y., Wang X., Ivey RG, Zhao L., Min H., Lee Y., Yu MH, Yang EG, Lee C., Wang P., Rodriguez H., Kim Y., Carr SA, et al. Nature methods, 2014/02/01, Volume 11, Issue 2, p.149-55, (2014) Read More / View Supplemental Materials
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Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas.Brastianos, PK, Taylor-Weiner A., Manley PE, Jones RT, Dias-Santagata D., Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L., Sunkavalli A., Shillingford N., Calicchio ML, Lidov HG, Taha H., Martinez-Lage M., Santi M., Storm PB, Lee JY, Palmer JN, et al. Nature genetics, 2014/02/01, Volume 46, Issue 2, p.161-5, (2014) Read More / View Supplemental Materials
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Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain.Colgrove, R., Diaz F., Newman R., Saif S., Shea T., Young S., Henn M., and Knipe DM Virology, 2014/02/01, Volume 450-451, p.140-5, (2014) Read More / View Supplemental Materials
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Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth.Stanley, SA, Barczak AK, Silvis MR, Luo SS, Sogi K., Vokes M., Bray MA, Carpenter AE, Moore CB, Siddiqi N., Rubin EJ, and Hung DT PLoS pathogens, 2014/02/01, Volume 10, Issue 2, p.e1003946, (2014) Read More / View Supplemental Materials
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The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection.Filone, CM, Caballero IS, Dower K., Mendillo ML, Cowley GS, Santagata S., Rozelle DK, Yen J., Rubins KH, Hacohen N., Root DE, Hensley LE, and Connor J. PLoS pathogens, 2014/02/01, Volume 10, Issue 2, p.e1003904, (2014) Read More / View Supplemental Materials
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Recent discoveries and applications involving small-molecule microarrays.Hong, JA, Neel DV, Wassaf D., Caballero F., and Koehler AN Current opinion in chemical biology, 2014/02/01, Volume 18C, p.21-28, (2014) Read More / View Supplemental Materials
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Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre.Hacisuleyman, E., Goff LA, Trapnell C., Williams A., Henao-Mejia J., Sun L., McClanahan P., Hendrickson DG, Sauvageau M., Kelley DR, Morse M., Engreitz J., Lander E. S., Guttman M., Lodish HF, Flavell R., Raj A., and Rinn JL Nature structural & molecular biology, 2014/02/01, Volume 21, Issue 2, p.198-206, (2014) Read More / View Supplemental Materials
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The evolution of lncRNA repertoires and expression patterns in tetrapods.Necsulea, A., Soumillon M., Warnefors M., Liechti A., Daish T., Zeller U., Baker JC, Grützner F., and Kaessmann H. Nature, 2014/01/30, Volume 505, Issue 7485, p.635-40, (2014) Read More / View Supplemental Materials
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Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests.Deme, AB, Park DJ, Bei AK, Sarr O., Badiane AS, Gueye Pel H., Ahouidi A., Ndir O., Mboup S., Wirth DF, Ndiaye D., and Volkman SK Malaria journal, 2014/01/29, Volume 13, Issue 1, p.34, (2014) Read More / View Supplemental Materials
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The genomic landscape of Neanderthal ancestry in present-day humans.Sankararaman, S., Mallick S., Dannemann M., Prüfer K., Kelso J., Pääbo S., Patterson N., and Reich D. Nature, 2014/01/29, (2014) Read More / View Supplemental Materials
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Meta'omic Analytic Techniques for Studying the Intestinal Microbiome.Morgan, XC, and Huttenhower C. Gastroenterology, 2014/01/28, (2014) Read More / View Supplemental Materials
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Searching for missing heritability: Designing rare variant association studies.Zuk, O., Schaffner SF, Samocha K., Do R., Hechter E., Kathiresan S., Daly M. J., Neale BM, Sunyaev SR, and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2014/01/28, Volume 111, Issue 4, p.E455-64, (2014) Read More / View Supplemental Materials
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Oncogenic RIT1 mutations in lung adenocarcinoma.Berger, AH, Imielinski M., Duke F., Wala J., Kaplan N., Shi GX, Andres DA, and Meyerson M. Oncogene, 2014/01/27, (2014) Read More / View Supplemental Materials
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Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European.Olalde, I., Allentoft ME, Sánchez-Quinto F., Santpere G., Chiang CW, Degiorgio M., Prado-Martinez J., Rodríguez JA, Rasmussen S., Quilez J., Ramírez O., Marigorta UM, Fernández-Callejo M., Prada ME, Encinas JM, Nielsen R., Netea MG, Novembre J., Sturm RA, Sabeti P., et al. Nature, 2014/01/26, (2014) Read More / View Supplemental Materials
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Epigenome-wide association studies without the need for cell-type composition.Zou, J., Lippert C., Heckerman D., Aryee M., and Listgarten J. Nature methods, 2014/01/26, (2014) Read More / View Supplemental Materials
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Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.Dancík, V., Carrel H., Bodycombe NE, Seiler KP, Fomina-Yadlin D., Kubicek ST, Hartwell K., Shamji AF, Wagner BK, and Clemons PA Journal of biomolecular screening, 2014/01/24, (2014) Read More / View Supplemental Materials
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Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.Nilsson, R., Jain M., Madhusudhan N., Sheppard NG, Strittmatter L., Kampf C., Huang J., Asplund A., and Mootha VK Nature communications, 2014/01/23, Volume 5, p.3128, (2014) Read More / View Supplemental Materials
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Translation of branched-chain aminotransferase-1 transcripts is impaired in cells haploinsufficient for ribosomal protein genes.Pereboom, TC, Bondt A., Pallaki P., Klasson T., Goos YJ, Essers PB, Koerkamp MG, Gazda HT, Holstege FC, and Macinnes AW Experimental hematology, 2014/01/23, (2014) Read More / View Supplemental Materials
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Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data.Radmanesh, F., Devan WJ, Anderson CD, Rosand J., and Falcone GJ European journal of human genetics : EJHG, 2014/01/22, (2014) Read More / View Supplemental Materials
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SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.Fowler, SA, Ananthakrishnan AN, Gardet A., Stevens CR, Korzenik JR, Sands BE, Daly M. J., Xavier RJ, and Yajnik V. Journal of Crohn's & colitis, 2014/01/22, (2014) Read More / View Supplemental Materials
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Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21.Hamrefors, V., Hedblad B., Hindy G., Smith JG, Almgren P., Engström G., Sjögren M., Gränsbo K., Orho-Melander M., and Melander O. PloS one, 2014/01/22, Volume 9, Issue 1, p.e85893, (2014) Read More / View Supplemental Materials
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In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene.Dunn, GP, Cheung HW, Agarwalla PK, Thomas S., Zektser Y., Karst AM, Boehm JS, Weir BA, Berlin AM, Zou L., Getz G., Liu JF, Hirsch M., Vazquez F., Root DE, Beroukhim R., Drapkin R., and Hahn WC Proceedings of the National Academy of Sciences of the United States of America, 2014/01/21, Volume 111, Issue 3, p.1102-7, (2014) Read More / View Supplemental Materials
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Inference of Tumor Evolution during Chemotherapy by Computational Modeling and In Situ Analysis of Genetic and Phenotypic Cellular Diversity.Almendro, V., Cheng YK, Randles A., Itzkovitz S., Marusyk A., Ametller E., Gonzalez-Farre X., Muñoz M., Russnes HG, Helland A., Rye IH, Borresen-Dale AL, Maruyama R., van Oudenaarden A., Dowsett M., Jones RL, Reis-Filho J., Gascon P., Gönen M., Michor F., et al. Cell reports, 2014/01/21, (2014) Read More / View Supplemental Materials
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Strength in numbers: comparing vaccine signatures the modular way.Haining, WN Nature immunology, 2014/01/21, Volume 15, Issue 2, p.139-41, (2014) Read More / View Supplemental Materials
Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.Zhu, Z., Aref AR, Cohoon TJ, Barbie TU, Imamura Y., Yang S., Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P., Godfrey JT, Qian ZR, Page AN, Maciag K., Chan EM, Silkworth W., Labowsky MT, Rozhansky L., et al. Cancer discovery, 2014/01/20, (2014) Read More / View Supplemental Materials
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Rare Copy Number Variation in Treatment-Resistant Major Depressive Disorder.O'Dushlaine, C., Ripke S., Ruderfer DM, Hamilton SP, Fava M., Iosifescu DV, Kohane IS, Churchill SE, Castro VM, Clements CC, Blumenthal SR, Murphy SN, Smoller JW, and Perlis RH Biological psychiatry, 2014/01/19, (2014) Read More / View Supplemental Materials
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The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated with Panic Disorder and Amygdala Structure and Function.Smoller, JW, Gallagher PJ, Duncan LE, McGrath LM, Haddad SA, Holmes AJ, Wolf AB, Hilker S., Block SR, Weill S., Young S., Choi EY, Rosenbaum JF, Biederman J., Faraone SV, Roffman JL, Manfro GG, Blaya C., Hirshfeld-Becker DR, Stein MB, et al. Biological psychiatry, 2014/01/18, (2014) Read More / View Supplemental Materials
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Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.Krönke, J., Udeshi ND, Narla A., Grauman P., Hurst SN, McConkey M., Svinkina T., Heckl D., Comer E., Li X., Ciarlo C., Hartman E., Munshi N., Schenone M., Schreiber SL, Carr SA, and Ebert BL Science (New York, N.Y.), 2014/01/17, Volume 343, Issue 6168, p.301-5, (2014) Read More / View Supplemental Materials
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Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories.Gräff, J., Joseph NF, Horn ME, Samiei A., Meng J., Seo J., Rei D., Bero AW, Phan TX, Wagner F., Holson E., Xu J., Sun J., Neve RL, Mach RH, Haggarty SJ, and Tsai LH Cell, 2014/01/16, Volume 156, Issue 1-2, p.261-76, (2014) Read More / View Supplemental Materials
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A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility.Damotte, V., Guillot-Noel L., Patsopoulos NA, Madireddy L., El Behi M., International Multiple Sclerosis Genetics Consortium, Ban M., Baranzini S., Barcellos L., Beecham G., Beecham A., Bernardinelli L., Booth D., Bos S., Buck D., Bush W., Comabella M., Compston A., Cotsapas C., Cournu-Rebeix I., et al. Genes and immunity, 2014/01/16, (2014) Read More / View Supplemental Materials
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The multilayered complexity of ceRNA crosstalk and competition.Tay, Y., Rinn J., and Pandolfi PP Nature, 2014/01/16, Volume 505, Issue 7483, p.344-52, (2014) Read More / View Supplemental Materials
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Multilocus Genetic Risk Score Associates With Ischemic Stroke in Case-Control and Prospective Cohort Studies.Malik, R., Bevan S., Nalls MA, Holliday EG, Devan WJ, Cheng YC, Ibrahim-Verbaas CA, Verhaaren BF, Bis JC, Joon AY, Destefano AL, Fornage M., Psaty BM, Ikram MA, Launer LJ, van Duijn CM, Sharma P., Mitchell BD, Rosand J., Meschia JF, et al. Stroke; a journal of cerebral circulation, 2014/01/16, (2014) Read More / View Supplemental Materials
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Predicting Stroke Through Genetic Risk Functions: The CHARGE Risk Score Project.Ibrahim-Verbaas, CA, Fornage M., Bis JC, Choi SH, Psaty BM, Meigs JB, Rao M., Nalls M., Fontes JD, O'Donnell CJ, Kathiresan S., Ehret GB, Fox CS, Malik R., Dichgans M., Schmidt H., Lahti J., Heckbert SR, Lumley T., Rice K., et al. Stroke; a journal of cerebral circulation, 2014/01/16, (2014) Read More / View Supplemental Materials
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Regulation of Ferroptotic Cancer Cell Death by GPX4.Yang, WS, Sriramaratnam R., Welsch ME, Shimada K., Skouta R., Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, and Stockwell BR Cell, 2014/01/16, Volume 156, Issue 1-2, p.317-31, (2014) Read More / View Supplemental Materials
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What we talk about when we talk about fat.Rosen, ED, and Spiegelman BM Cell, 2014/01/16, Volume 156, Issue 1-2, p.20-44, (2014) Read More / View Supplemental Materials
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Insights from monogenic diabetes and glycemic treatment goals for common types of diabetes.Florez, JC JAMA : the journal of the American Medical Association, 2014/01/15, Volume 311, Issue 3, p.249-51, (2014) Read More / View Supplemental Materials
Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance.Kats, LM, Reschke M., Taulli R., Pozdnyakova O., Burgess K., Bhargava P., Straley K., Karnik R., Meissner A., Small D., Su SM, Yen K., Zhang J., and Pandolfi PP Cell stem cell, 2014/01/15, (2014) Read More / View Supplemental Materials
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ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State.Chudnovsky, Y., Kim D., Zheng S., Whyte WA, Bansal M., Bray MA, Gopal S., Theisen MA, Bilodeau S., Thiru P., Muffat J., Yilmaz OH, Mitalipova M., Woolard K., Lee J., Nishimura R., Sakata N., Fine HA, Carpenter AE, Silver SJ, et al. Cell reports, 2014/01/15, (2014) Read More / View Supplemental Materials
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Autophagy is essential for cardiac morphogenesis during vertebrate development.Lee, E., Koo Y., Ng A., Wei Y., Luby-Phelps K., Juraszek A., Xavier RJ, Cleaver O., Levine B., and Amatruda JF Autophagy, 2014/01/14, Volume 10, Issue 4, (2014) Read More / View Supplemental Materials
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Differential Effect of Genetic Burden on Disease Phenotypes in Crohn's Disease and Ulcerative Colitis: Analysis of a North American Cohort.Ananthakrishnan, AN, Huang H., Nguyen DD, Sauk J., Yajnik V., and Xavier RJ The American journal of gastroenterology, 2014/01/14, (2014) Read More / View Supplemental Materials
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Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance.Lukens, AK, Ross LS, Heidebrecht R., Javier Gamo F., Lafuente-Monasterio MJ, Booker ML, Hartl DL, Wiegand RC, and Wirth DF Proceedings of the National Academy of Sciences of the United States of America, 2014/01/14, Volume 111, Issue 2, p.799-804, (2014) Read More / View Supplemental Materials
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De novo fatty acid synthesis at the mitotic exit is required to complete cellular division.Scaglia, N., Tyekucheva S., Zadra G., Photopoulos C., and Loda M. Cell cycle (Georgetown, Tex.), 2014/01/13, Volume 13, Issue 5, (2014) Read More / View Supplemental Materials
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Using transcription of six Puccinia triticina races to identify the effective secretome during infection of wheat.Bruce, M., Neugebauer KA, Joly DL, Migeon P., Cuomo CA, Wang S., Akhunov E., Bakkeren G., Kolmer JA, and Fellers JP Frontiers in plant science, 2014/01/13, Volume 4, p.520, (2014) Read More / View Supplemental Materials
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Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.Lohr, JG, Stojanov P., Carter SL, Cruz-Gordillo P., Lawrence MS, Auclair D., Sougnez C., Knoechel B., Gould J., Saksena G., Cibulskis K., McKenna A., Chapman MA, Straussman R., Levy J., Perkins LM, Keats JJ, Schumacher SE, Rosenberg M., Multiple Myeloma Research Consortium, et al. Cancer cell, 2014/01/13, Volume 25, Issue 1, p.91-101, (2014) Read More / View Supplemental Materials
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Common Variation in Fatty Acid Metabolic Genes and Risk of Incident Sudden Cardiac Arrest.Lemaitre, RN, Johnson CO, Hesselson S., Sotoodhenia N., McKnight B., Sitlani CM, Rea TD, King IB, Kwok PY, Mak A., Li G., Brody J., Larson E., Mozaffarian D., Psaty BM, Huertas-Vazquez A., Tardif JC, Albert CM, Lyytikäinen LP, Arking DE, et al. Heart rhythm : the official journal of the Heart Rhythm Society, 2014/01/10, (2014) Read More / View Supplemental Materials
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β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors.Roberts, LD, Boström P., O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A., Lee YK, Palma MJ, Calhoun S., Georgiadi A., Chen MH, Ramachandran VS, Larson MG, Bouchard C., Rankinen T., Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, et al. Cell metabolism, 2014/01/07, Volume 19, Issue 1, p.96-108, (2014) Read More / View Supplemental Materials
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Discovery and saturation analysis of cancer genes across 21 tumour types.Lawrence, MS, Stojanov P., Mermel CH, Robinson JT, Garraway LA, Golub T. R., Meyerson M., Gabriel SB, Lander E. S., and Getz G. Nature, 2014/01/05, (2014) Read More / View Supplemental Materials
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Genome-scale CRISPR-Cas9 knockout screening in human cells.Shalem, O., Sanjana NE, Hartenian E., Shi X., Scott DA, Mikkelsen TS, Heckl D., Ebert BL, Root DE, Doench JG, and Zhang F. Science (New York, N.Y.), 2014/01/03, Volume 343, Issue 6166, p.84-7, (2014) Read More / View Supplemental Materials
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The complete genome sequence of a Neanderthal from the Altai Mountains.Prüfer, K., Racimo F., Patterson N., Jay F., Sankararaman S., Sawyer S., Heinze A., Renaud G., Sudmant PH, de Filippo C., Li H., Mallick S., Dannemann M., Fu Q., Kircher M., Kuhlwilm M., Lachmann M., Meyer M., Ongyerth M., Siebauer M., et al. Nature, 2014/01/02, Volume 505, Issue 7481, p.43-9, (2014) Read More / View Supplemental Materials
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The influence of polygenic risk scores on heritability of anti-CCP level in RA.Cui, J., Taylor KE, Lee YC, Källberg H., Weinblatt ME, Coblyn JS, Klareskog L., Criswell LA, Gregersen PK, Shadick NA, Plenge RM, and Karlson EW Genes and immunity, 2014/01/02, (2014) Read More / View Supplemental Materials
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