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2014
Regulatory T cells in autoimmune neuroinflammation.Kleinewietfeld, M., and Hafler DA Immunological reviews, 2014/05/01, Volume 259, Issue 1, p.231-44, (2014) Read More / View Supplemental Materials
Abstract
Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway.Heijnen, HF, van Wijk R., Pereboom TC, Goos YJ, Seinen CW, van Oirschot BA, van Dooren R., Gastou M., Giles RH, van Solinge W., Kuijpers TW, Gazda HT, Bierings MB, Da Costa L., and Macinnes AW PLoS genetics, 2014/05/01, Volume 10, Issue 5, p.e1004371, (2014) Read More / View Supplemental Materials
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Selectivity in Genetic Association with Sub-classified Migraine in Women.Chasman, DI, Anttila V., Buring JE, Ridker PM, Schürks M., Kurth T., and International Headache Genetics Consortium PLoS genetics, 2014/05/01, Volume 10, Issue 5, p.e1004366, (2014) Read More / View Supplemental Materials
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Simulation of finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland.Wang, SR, Agarwala V., Flannick J., Chiang CW, Altshuler D., GoT2D Consortium, and Hirschhorn JN American journal of human genetics, 2014/05/01, Volume 94, Issue 5, p.710-20, (2014) Read More / View Supplemental Materials
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Towards Engineered Processes for Sequencing-Based Analysis of Single Circulating Tumor Cells.Adalsteinsson, VA, and Love JC Current opinion in chemical engineering, 2014/05/01, Volume 4, p.97-104, (2014) Read More / View Supplemental Materials
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Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer.Lohr, JG, Adalsteinsson VA, Cibulskis K., Choudhury AD, Rosenberg M., Cruz-Gordillo P., Francis JM, Zhang CZ, Shalek AK, Satija R., Trombetta JJ, Lu D., Tallapragada N., Tahirova N., Kim S., Blumenstiel B., Sougnez C., Lowe A., Wong B., Auclair D., et al. Nature biotechnology, 2014/05/01, Volume 32, Issue 5, p.479-84, (2014) Read More / View Supplemental Materials
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Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation.Avanesov, AS, Ma S., Pierce KA, Yim SH, Lee BC, Clish CB, and Gladyshev VN eLife, 2014/04/29, Volume 3, p.e02077, (2014) Read More / View Supplemental Materials
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'Lnc'-ing enhancers to MYC regulation.Younger, ST, and Rinn JL Cell research, 2014/04/29, (2014) Read More / View Supplemental Materials
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Natural selection and infectious disease in human populations.Karlsson, EK, Kwiatkowski DP, and Sabeti PC Nature reviews. Genetics, 2014/04/29, (2014) Read More / View Supplemental Materials
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High- and low-throughput scoring of fat mass and body fat distribution in C. elegans.Wählby, C., Lee Conery A., Bray MA, Kamentsky L., Larkins-Ford J., Sokolnicki KL, Veneskey M., Michaels K., Carpenter AE, and O'Rourke EJ Methods (San Diego, Calif.), 2014/04/28, (2014) Read More / View Supplemental Materials
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Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer.Forsberg, LA, Rasi C., Malmqvist N., Davies H., Pasupulati S., Pakalapati G., Sandgren J., de Ståhl TD, Zaghlool A., Giedraitis V., Lannfelt L., Score J., Cross NC, Absher D., Janson ET, Lindgren CM, Morris AP, Ingelsson E., Lind L., and Dumanski JP Nature genetics, 2014/04/28, (2014) Read More / View Supplemental Materials
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Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL.Wang, L., Shalek AK, Lawrence M., Ding R., Gaublomme JT, Pochet N., Stojanov P., Sougnez C., Shukla SA, Stevenson KE, Zhang W., Wong J., Sievers QL, Macdonald BT, Vartanov AR, Goldstein NR, Neuberg D., He X., Lander E., Hacohen N., et al. Blood, 2014/04/28, (2014) Read More / View Supplemental Materials
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A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors.Konieczkowski, DJ, Johannessen CM, Abudayyeh O., Kim JW, Cooper ZA, Piris A., Frederick DT, Barzily-Rokni M., Straussman R., Haq R., Fisher DE, Mesirov J. P., Hahn WC, Flaherty KT, Wargo JA, Tamayo P., and Garraway LA Cancer discovery, 2014/04/25, (2014) Read More / View Supplemental Materials
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PRADA: pipeline for RNA sequencing data analysis.Torres-García, W., Zheng S., Sivachenko A., Vegesna R., Wang Q., Yao R., Berger MF, Weinstein J. N., Getz G., and Verhaak RG Bioinformatics (Oxford, England), 2014/04/25, (2014) Read More / View Supplemental Materials
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CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration.Schaffer, AE, Eggens VR, Caglayan AO, Reuter MS, Scott E., Coufal NG, Silhavy JL, Xue Y., Kayserili H., Yasuno K., Rosti RO, Abdellateef M., Caglar C., Kasher PR, Cazemier JL, Weterman MA, Cantagrel V., Cai N., Zweier C., Altunoglu U., et al. Cell, 2014/04/24, Volume 157, Issue 3, p.651-63, (2014) Read More / View Supplemental Materials
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Guidelines for investigating causality of sequence variants in human disease.Macarthur, DG, Manolio TA, Dimmock DP, Rehm HL, Shendure J., Abecasis GR, Adams DR, Altman RB, Antonarakis SE, Ashley EA, Barrett JC, Biesecker LG, Conrad DF, Cooper GM, Cox NJ, Daly M. J., Gerstein MB, Goldstein DB, Hirschhorn JN, Leal SM, et al. Nature, 2014/04/24, Volume 508, Issue 7497, p.469-76, (2014) Read More / View Supplemental Materials
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Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.Placke, T., Faber K., Nonami A., Putwain SL, Salih HR, Heidel FH, Krämer A., Root DE, Barbie DA, Krivtsov AV, Armstrong SA, Hahn WC, Huntly BJ, Sykes SM, Milsom MD, Scholl C., and Fröhling S. Blood, 2014/04/24, (2014) Read More / View Supplemental Materials
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Targeted genomic rearrangements using CRISPR/Cas technology.Choi, PS, and Meyerson M. Nature communications, 2014/04/24, Volume 5, p.3728, (2014) Read More / View Supplemental Materials
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Using XHMM Software to Detect Copy Number Variation in Whole-Exome Sequencing Data.Fromer, M., and Purcell SM Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.], 2014/04/24, Volume 81, p.7.23.1-7.23.21, (2014) Read More / View Supplemental Materials
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Constant Growth Rate Can Be Supported by Decreasing Energy Flux and Increasing Aerobic Glycolysis.Slavov, N., Budnik BA, Schwab D., Airoldi EM, and van Oudenaarden A. Cell reports, 2014/04/23, (2014) Read More / View Supplemental Materials
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Contributions of the social environment to first-onset and recurrent mania.Gilman, SE, Ni MY, Dunn EC, Breslau J., McLaughlin KA, Smoller JW, and Perlis RH Molecular psychiatry, 2014/04/22, (2014) Read More / View Supplemental Materials
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RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice.Efeyan, A., Schweitzer LD, Bilate AM, Chang S., Kirak O., Lamming DW, and Sabatini DM Developmental cell, 2014/04/22, (2014) Read More / View Supplemental Materials
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Medicine's Uncomfortable Relationship With Math: Calculating Positive Predictive Value.Manrai, AK, Bhatia G., Strymish J., Kohane IS, and Jain SH JAMA internal medicine, 2014/04/21, (2014) Read More / View Supplemental Materials
Response to letter to the Editor.McLean, SA, Ulirsch JC, and Bortsov AV Pain, 2014/04/21, (2014) Read More / View Supplemental Materials
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells.Wu, X., Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S., Chen S., Jaenisch R., Zhang F., and Sharp PA Nature biotechnology, 2014/04/20, (2014) Read More / View Supplemental Materials
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Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.Lane, AA, Chapuy B., Lin CY, Tivey T., Li H., Townsend EC, van Bodegom D., Day TA, Wu SC, Liu H., Yoda A., Alexe G., Schinzel AC, Sullivan TJ, Malinge S., Taylor JE, Stegmaier K., Jaffe JD, Bustin M., Te Kronnie G., et al. Nature genetics, 2014/04/20, (2014) Read More / View Supplemental Materials
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Limit of metastability for liquid and vapor phases of water.Cho, WJ, Kim J., Lee J., Keyes T., Straub JE, and Kim KS Physical review letters, 2014/04/18, Volume 112, Issue 15, p.157802, (2014) Read More / View Supplemental Materials
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Methods for targeted mutagenesis in zebrafish using TALENs.Hwang, WY, Peterson RT, and Yeh JR Methods (San Diego, Calif.), 2014/04/18, (2014) Read More / View Supplemental Materials
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Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.Xiao, S., Yosef N., Yang J., Wang Y., Zhou L., Zhu C., Wu C., Baloglu E., Schmidt D., Ramesh R., Lobera M., Sundrud MS, Tsai PY, Xiang Z., Wang J., Xu Y., Lin X., Kretschmer K., Rahl PB, Young RA, et al. Immunity, 2014/04/17, Volume 40, Issue 4, p.477-89, (2014) Read More / View Supplemental Materials
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Describing Sequencing Results of Structural Chromosome Rearrangements with a Suggested Next-Generation Cytogenetic Nomenclature.Ordulu, Z., Wong KE, Currall BB, Ivanov AR, Pereira S., Althari S., Gusella JF, Talkowski ME, and Morton CC American journal of human genetics, 2014/04/16, (2014) Read More / View Supplemental Materials
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Functional Genomic Analysis of Human Mitochondrial RNA Processing.Wolf, AR, and Mootha VK Cell reports, 2014/04/16, (2014) Read More / View Supplemental Materials
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Heterogeneity in immune responses: from populations to single cells.Satija, R., and Shalek AK Trends in immunology, 2014/04/16, (2014) Read More / View Supplemental Materials
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Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis.Rampal, R., Al-Shahrour F., Abdel-Wahab O., Patel J., Brunel JP, Mermel CH, Bass AJ, Pretz J., Ahn J., Hricik T., Kilpivaara O., Wadleigh M., Busque L., Gilliland DG, Golub T. R., Ebert BL, and LeVine R. Blood, 2014/04/16, (2014) Read More / View Supplemental Materials
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Maximizing the Power of Principal Components Analysis of Correlated Phenotypes in Genome-wide Association Studies.Aschard, H., Vilhjálmsson BJ, Greliche N., Morange PE, Trégouët DA, and Kraft P. American journal of human genetics, 2014/04/15, (2014) Read More / View Supplemental Materials
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A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein.Pop, MS, Stransky N., Garvie CW, Theurillat JP, Lewis TA, Zhong C., Culyba EK, Lin F., Daniels DS, Pagliarini R., Ronco L., Koehler AN, and Garraway LA Molecular cancer therapeutics, 2014/04/15, (2014) Read More / View Supplemental Materials
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Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment.Seo, J., Giusti-Rodríguez P., Zhou Y., Rudenko A., Cho S., Ota KT, Park C., Patzke H., Madabhushi R., Pan L., Mungenast AE, Guan JS, Delalle I., and Tsai LH Cell, 2014/04/10, Volume 157, Issue 2, p.486-98, (2014) Read More / View Supplemental Materials
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Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells.Chen, WW, Birsoy K., Mihaylova MM, Snitkin H., Stasinski I., Yucel B., Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, and Sabatini DM Cell reports, 2014/04/10, Volume 7, Issue 1, p.27-34, (2014) Read More / View Supplemental Materials
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Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.Wainger, BJ, Kiskinis E., Mellin C., Wiskow O., Han SS, Sandoe J., Perez NP, Williams LA, Lee S., Boulting G., Berry JD, Brown RH Jr, Cudkowicz ME, Bean BP, Eggan K., and Woolf CJ Cell reports, 2014/04/10, Volume 7, Issue 1, p.1-11, (2014) Read More / View Supplemental Materials
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Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells.Suvà, ML, Rheinbay E., Gillespie SM, Patel AP, Wakimoto H., Rabkin SD, Riggi N., Chi AS, Cahill DP, Nahed BV, Curry WT, Martuza RL, Rivera MN, Rossetti N., Kasif S., Beik S., Kadri S., Tirosh I., Wortman I., Shalek AK, et al. Cell, 2014/04/09, (2014) Read More / View Supplemental Materials
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Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles.Wawer, MJ, Jaramillo DE, Dančik V., Fass DM, Haggarty SJ, Shamji AF, Wagner BK, Schreiber SL, and Clemons PA Journal of biomolecular screening, 2014/04/07, (2014) Read More / View Supplemental Materials
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Increasing the Content of High-Content Screening: An Overview.Singh, S., Carpenter AE, and Genovesio A. Journal of biomolecular screening, 2014/04/07, (2014) Read More / View Supplemental Materials
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Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity.Han, B., Diogo D., Eyre S., Kallberg H., Zhernakova A., Bowes J., Padyukov L., Okada Y., González-Gay MA, Rantapää-Dahlqvist S., Martin J., Huizinga TW, Plenge RM, Worthington J., Gregersen PK, Klareskog L., de Bakker PI, and Raychaudhuri S. American journal of human genetics, 2014/04/03, Volume 94, Issue 4, p.522-32, (2014) Read More / View Supplemental Materials
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Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage.Woo, D., Falcone GJ, Devan WJ, Brown WM, Biffi A., Howard TD, Anderson CD, Brouwers HB, Valant V., Battey TW, Radmanesh F., Raffeld MR, Baedorf-Kassis S., Deka R., Woo JG, Martin LJ, Haverbusch M., Moomaw CJ, Sun G., Broderick JP, et al. American journal of human genetics, 2014/04/03, Volume 94, Issue 4, p.511-21, (2014) Read More / View Supplemental Materials
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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.Birsoy, K., Possemato R., Lorbeer FK, Bayraktar EC, Thiru P., Yucel B., Wang T., Chen WW, Clish CB, and Sabatini DM Nature, 2014/04/03, Volume 508, Issue 7494, p.108-12, (2014) Read More / View Supplemental Materials
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Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-Cerebellar Atrophy, and Intractable Seizures.Zhang, X., Ling J., Barcia G., Jing L., Wu J., Barry BJ, Mochida GH, Hill RS, Weimer JM, Stein Q., Poduri A., Partlow JN, Ville D., Dulac O., Yu TW, Lam AT, Servattalab S., Rodriguez J., Boddaert N., Munnich A., et al. American journal of human genetics, 2014/04/03, Volume 94, Issue 4, p.547-58, (2014) Read More / View Supplemental Materials
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Perspective: Revealing molecular secrets.Hyman, SE Nature, 2014/04/03, Volume 508, Issue 7494, p.S20, (2014) Read More / View Supplemental Materials
Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation.Janbon, G., Ormerod KL, Paulet D., Byrnes EJ 3rd, Yadav V., Chatterjee G., Mullapudi N., Hon CC, Billmyre RB, Brunel F., Bahn YS, Chen W., Chen Y., Chow EW, Coppée JY, Floyd-Averette A., Gaillardin C., Gerik KJ, Goldberg J., Gonzalez-Hilarion S., et al. PLoS genetics, 2014/04/01, Volume 10, Issue 4, p.e1004261, (2014) Read More / View Supplemental Materials
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A Central Role for GRB10 in Regulation of Islet Function in Man.Prokopenko, I., Poon W., Mägi R., Prasad B R., Salehi SA, Almgren P., Osmark P., Bouatia-Naji N., Wierup N., Fall T., Stančáková A., Barker A., Lagou V., Osmond C., Xie W., Lahti J., Jackson AU, Cheng YC, Liu J., O'Connell JR, et al. PLoS genetics, 2014/04/01, Volume 10, Issue 4, p.e1004235, (2014) Read More / View Supplemental Materials
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Current concepts and clinical applications of stroke genetics.Falcone, GJ, Malik R., Dichgans M., and Rosand J. Lancet neurology, 2014/04/01, Volume 13, Issue 4, p.405-418, (2014) Read More / View Supplemental Materials
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The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells.Trapnell, C., Cacchiarelli D., Grimsby J., Pokharel P., Li S., Morse M., Lennon NJ, Livak KJ, Mikkelsen TS, and Rinn JL Nature biotechnology, 2014/04/01, Volume 32, Issue 4, p.381-6, (2014) Read More / View Supplemental Materials
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Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history.Bergen, SE, O'Dushlaine CT, Lee PH, Fanous AH, Ruderfer DM, Ripke S., International Schizophrenia Consortium, Swedish Schizophrenia Consortium, Sullivan PF, Smoller JW, Purcell SM, and Corvin A. Schizophrenia research, 2014/04/01, Volume 154, Issue 1-3, p.48-53, (2014) Read More / View Supplemental Materials
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Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.Flannick, J., Thorleifsson G., Beer NL, Jacobs SB, Grarup N., Burtt NP, Mahajan A., Fuchsberger C., Atzmon G., Benediktsson R., Blangero J., Bowden DW, Brandslund I., Brosnan J., Burslem F., Chambers J., Cho YS, Christensen C., Douglas DA, Duggirala R., et al. Nature genetics, 2014/04/01, Volume 46, Issue 4, p.357-63, (2014) Read More / View Supplemental Materials
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Simplified and Efficient Quantification of Low-abundance Proteins at Very High Multiplex via Targeted Mass Spectrometry.Burgess, MW, Keshishian H., Mani D. R., Gillette MA, and Carr SA Molecular & cellular proteomics : MCP, 2014/04/01, Volume 13, Issue 4, p.1137-49, (2014) Read More / View Supplemental Materials
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SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas.Watanabe, H., Ma Q., Peng S., Adelmant G., Swain D., Song W., Fox C., Francis JM, Pedamallu CS, Deluca DS, Brooks AN, Wang S., Que J., Rustgi AK, Wong KK, Ligon KL, Liu XS, Marto JA, Meyerson M., and Bass AJ The Journal of clinical investigation, 2014/04/01, Volume 124, Issue 4, p.1636-45, (2014) Read More / View Supplemental Materials
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Regulation of mTORC1 by amino acids.Bar-Peled, L., and Sabatini DM Trends in cell biology, 2014/03/31, (2014) Read More / View Supplemental Materials
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Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib.Wagle, N., Grabiner BC, Van Allen EM, Hodis E., Jacobus S., Supko JG, Stewart M., Choueiri TK, Gandhi L., Cleary JM, Elfiky AA, Taplin ME, Stack EC, Signoretti S., Loda M., Shapiro GI, Sabatini DM, Lander E. S., Gabriel SB, Kantoff PW, et al. Cancer discovery, 2014/03/27, (2014) Read More / View Supplemental Materials
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Human CFEOM1 Mutations Attenuate KIF21A Autoinhibition and Cause Oculomotor Axon Stalling.Cheng, L., Desai J., Miranda CJ, Duncan JS, Qiu W., Nugent AA, Kolpak AL, Wu CC, Drokhlyansky E., Delisle MM, Chan WM, Wei Y., Propst F., Reck-Peterson SL, Fritzsch B., and Engle EC Neuron, 2014/03/18, (2014) Read More / View Supplemental Materials
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Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition.Kool, M., Jones DT, Jäger N., Northcott PA, Pugh TJ, Hovestadt V., Piro RM, Esparza LA, Markant SL, Remke M., Milde T., Bourdeaut F., Ryzhova M., Sturm D., Pfaff E., Stark S., Hutter S., Seker-Cin H., Johann P., Bender S., et al. Cancer cell, 2014/03/17, Volume 25, Issue 3, p.393-405, (2014) Read More / View Supplemental Materials
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Central Precocious Puberty that appears to be sporadic caused by Paternally inherited mutations in the imprinted GENE makorin ring finger 3.Macedo, DB, Abreu AP, Reis AC, Montenegro LR, Dauber A., Beneduzzi D., Cukier P., Silveira LF, Teles MG, Carroll RS, Guerra Junior G., Guaragna Filho G., Gucev Z., Arnhold IJ, de Castro M., Moreira AC, Martinelli CE Jr, Hirschhorn JN, Mendonca BB, Brito VN, et al. The Journal of clinical endocrinology and metabolism, 2014/03/14, p.jc20133126, (2014) Read More / View Supplemental Materials
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Time for new schizophrenia Rx.Hyman, SE Science (New York, N.Y.), 2014/03/14, Volume 343, Issue 6176, p.1177, (2014) Read More / View Supplemental Materials
Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing.McFadden, DG, Papagiannakopoulos T., Taylor-Weiner A., Stewart C., Carter SL, Cibulskis K., Bhutkar A., McKenna A., Dooley A., Vernon A., Sougnez C., Malstrom S., Heimann M., Park J., Chen F., Farago AF, Dayton T., Shefler E., Gabriel S., Getz G., et al. Cell, 2014/03/13, Volume 156, Issue 6, p.1298-311, (2014) Read More / View Supplemental Materials
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Microbes, Microbiota, and Colon Cancer.Sears, CL, and Garrett WS Cell host & microbe, 2014/03/12, Volume 15, Issue 3, p.317-328, (2014) Read More / View Supplemental Materials
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The treatment-naive microbiome in new-onset Crohn's disease.Gevers, D., Kugathasan S., Denson LA, Vázquez-Baeza Y., Van Treuren W., Ren B., Schwager E., Knights D., Song SJ, Yassour M., Morgan XC, Kostic AD, Luo C., González A., McDonald D., Haberman Y., Walters T., Baker S., Rosh J., Stephens M., et al. Cell host & microbe, 2014/03/12, Volume 15, Issue 3, p.382-92, (2014) Read More / View Supplemental Materials
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Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters.Naba, A., Clauser KR, Lamar JM, Carr SA, and Hynes R. O. eLife, 2014/03/11, Volume 3, p.e01308, (2014) Read More / View Supplemental Materials
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In Vivo and in vitro dynamics of undifferentiated embryonic cell transcription factor 1.Galonska, C., Smith ZD, and Meissner A. Stem cell reports, 2014/03/11, Volume 2, Issue 3, p.245-52, (2014) Read More / View Supplemental Materials
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Common genetic variants modulate pathogen-sensing responses in human dendritic cells.Lee, MN, Ye C., Villani AC, Raj T., Li W., Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K., Ward LD, Raddassi K., McCabe C., Lee MH, Frohlich IY, Hafler DA, Kellis M., Raychaudhuri S., Zhang F., Stranger BE, et al. Science (New York, N.Y.), 2014/03/07, Volume 343, Issue 6175, p.1246980, (2014) Read More / View Supplemental Materials
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2013 Victor A. McKusick Leadership Award Introduction: Kurt and Rochelle Hirschhorn.Hirschhorn, JN American journal of human genetics, 2014/03/06, Volume 94, Issue 3, p.334-5, (2014) Read More / View Supplemental Materials
Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer.Mihaylova, MM, Sabatini DM, and Yilmaz OH Cell stem cell, 2014/03/06, Volume 14, Issue 3, p.292-305, (2014) Read More / View Supplemental Materials
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An excess of risk-increasing low-frequency variants can be a signal of polygenic inheritance in complex diseases.Chan, Y., Lim ET, Sandholm N., Wang SR, McKnight AJ, Ripke S., DIAGRAM Consortium, GENIE Consortium, GIANT Consortium, IIBDGC Consortium, PGC Consortium, Daly M. J., Neale BM, Salem RM, and Hirschhorn JN American journal of human genetics, 2014/03/06, Volume 94, Issue 3, p.437-52, (2014) Read More / View Supplemental Materials
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Functional and phylogenetic assembly of microbial communities in the human microbiome.Shafquat, A., Joice R., Simmons SL, and Huttenhower C. Trends in microbiology, 2014/03/04, (2014) Read More / View Supplemental Materials
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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.Knoechel, B., Roderick JE, Williamson KE, Zhu J., Lohr JG, Cotton MJ, Gillespie SM, Fernandez D., Ku M., Wang H., Piccioni F., Silver SJ, Jain M., Pearson D., Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A., et al. Nature genetics, 2014/03/02, (2014) Read More / View Supplemental Materials
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The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells.Kurachi, M., Barnitz RA, Yosef N., Odorizzi PM, Diiorio MA, Lemieux ME, Yates K., Godec J., Klatt MG, Regev A., Wherry EJ, and Haining WN Nature immunology, 2014/03/02, (2014) Read More / View Supplemental Materials
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A121: in search of infectious triggers of periodic Fever, aphthous stomatitis, pharyngitis and adenitis syndrome.Freeman, S., Bhatt A., Pedamallu C., King S., Duke F., Jung J., Lawton M., Anderson E., Fuhlbrigge RC, Kenna M., Licameli G., Meyerson M., and Dedeoglu F. Arthritis & rheumatology (Hoboken, N.J.), 2014/03/01, Volume 66 Suppl 11, p.S158, (2014) Read More / View Supplemental Materials
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ARID1B is a specific vulnerability in ARID1A-mutant cancers.Helming, KC, Wang X., Wilson BG, Vazquez F., Haswell JR, Manchester HE, Kim Y., Kryukov GV, Ghandi M., Aguirre AJ, Jagani Z., Wang Z., Garraway LA, Hahn WC, and Roberts CW Nature medicine, 2014/03/01, Volume 20, Issue 3, p.251-4, (2014) Read More / View Supplemental Materials
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Genetic Dissection of Anopheles gambiae Gut Epithelial Responses to Serratia marcescens.Stathopoulos, S., Neafsey DE, Lawniczak MK, Muskavitch MA, and Christophides GK PLoS pathogens, 2014/03/01, Volume 10, Issue 3, p.e1003897, (2014) Read More / View Supplemental Materials
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Lassa Fever in post-conflict sierra leone.Shaffer, JG, Grant DS, Schieffelin JS, Boisen ML, Goba A., Hartnett JN, Levy DC, Yenni RE, Moses LM, Fullah M., Momoh M., Fonnie M., Fonnie R., Kanneh L., Koroma VJ, Kargbo K., Ottomassathien D., Muncy IJ, Jones AB, Illick MM, et al. PLoS neglected tropical diseases, 2014/03/01, Volume 8, Issue 3, p.e2748, (2014) Read More / View Supplemental Materials
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Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation.Wilson, BG, Helming KC, Wang X., Kim Y., Vazquez F., Jagani Z., Hahn WC, and Roberts CW Molecular and cellular biology, 2014/03/01, Volume 34, Issue 6, p.1136-44, (2014) Read More / View Supplemental Materials
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Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach.Carr, SA, Abbatiello SE, Ackermann BL, Borchers C., Domon B., Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R., Koomen JM, Liebler DC, Liu T., Maclean B., Mani D., Mansfield E., Neubert H., Paulovich AG, Reiter L., Vitek O., Aebersold R., et al. Molecular & cellular proteomics : MCP, 2014/03/01, Volume 13, Issue 3, p.907-17, (2014) Read More / View Supplemental Materials
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Understanding Th17 cells through systematic genomic analyses.Peters, A., and Yosef N. Current opinion in immunology, 2014/03/01, Volume 28C, p.42-48, (2014) Read More / View Supplemental Materials
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Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue.Shi, J., Marconett CN, Duan J., Hyland PL, Li P., Wang Z., Wheeler W., Zhou B., Campan M., Lee DS, Huang J., Zhou W., Triche T., Amundadottir L., Warner A., Hutchinson A., Chen PH, Chung BS, Pesatori AC, Consonni D., et al. Nature communications, 2014/02/27, Volume 5, p.3365, (2014) Read More / View Supplemental Materials
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Crystal structure of cas9 in complex with guide RNA and target DNA.Nishimasu, H., Ran FA, Hsu PD, Konermann S., Shehata SI, Dohmae N., Ishitani R., Zhang F., and Nureki O. Cell, 2014/02/27, Volume 156, Issue 5, p.935-49, (2014) Read More / View Supplemental Materials
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Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2.Huang, J., Huffman JE, Yamkauchi M., Trompet S., Asselbergs FW, Sabater-Lleal M., Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W., Dehghan A., Johnson AD, Truong V., Folkersen L., Yang Q., Oudot-Mellkah T., Buckley BM, et al. Arteriosclerosis, thrombosis, and vascular biology, 2014/02/27, (2014) Read More / View Supplemental Materials
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Genome-Wide Genotyping Demonstrates a Polygenic Risk Score Associated With White Matter Hyperintensity Volume in CADASIL.Opherk, C., Gonik M., Duering M., Malik R., Jouvent E., Hervé D., Adib-Samii P., Bevan S., Pianese L., Silvestri S., Dotti MT, De Stefano N., Liem M., Boon EM, Pescini F., Pachai C., Bracoud L., Müller-Myhsok B., Meitinger T., Rost N., et al. Stroke; a journal of cerebral circulation, 2014/02/27, (2014) Read More / View Supplemental Materials
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Detection and replication of epistasis influencing transcription in humans.Hemani, G., Shakhbazov K., Westra HJ, Esko T., Henders AK, McRae AF, Yang J., Gibson G., Martin NG, Metspalu A., Franke L., Montgomery GW, Visscher PM, and Powell JE Nature, 2014/02/26, (2014) Read More / View Supplemental Materials
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Prostaglandin E2 Regulates Liver versus Pancreas Cell-Fate Decisions and Endodermal Outgrowth.Nissim, S., Sherwood RI, Wucherpfennig J., Saunders D., Harris JM, Esain V., Carroll KJ, Frechette GM, Kim AJ, Hwang KL, Cutting CC, Elledge S., North TE, and Goessling W. Developmental cell, 2014/02/24, Volume 28, Issue 4, p.423-37, (2014) Read More / View Supplemental Materials
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Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci.Tragante, V., Barnes MR, Ganesh SK, Lanktree MB, Guo W., Franceschini N., Smith EN, Johnson T., Holmes MV, Padmanabhan S., Karczewski KJ, Almoguera B., Barnard J., Baumert J., Chang YP, Elbers CC, Farrall M., Fischer ME, Gaunt TR, Gho JM, et al. American journal of human genetics, 2014/02/19, (2014) Read More / View Supplemental Materials
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The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.Kostic, AD, Xavier RJ, and Gevers D. Gastroenterology, 2014/02/18, (2014) Read More / View Supplemental Materials
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Genetic Association Analysis of 300 Genes Identifies a Risk Haplotype in SLC18A2 for Posttraumatic Stress Disorder in two Independent Samples.Solovieff, N., Roberts AL, Ratanatharathorn A., Haloosim M., De Vivo I., King AP, Liberzon I., Aiello A., Uddin M., Wildman DE, Galea S., Smoller JW, Purcell SM, and Koenen KC Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014/02/14, (2014) Read More / View Supplemental Materials
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Targeting the pancreatic β-cell to treat diabetes.Vetere, A., Choudhary A., Burns SM, and Wagner BK Nature reviews. Drug discovery, 2014/02/14, (2014) Read More / View Supplemental Materials
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De novo mutations in schizophrenia implicate synaptic networks.Fromer, M., Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S., Gormley P., Georgieva L., Rees E., Palta P., Ruderfer DM, Carrera N., Humphreys I., Johnson JS, Roussos P., Barker DD, Banks E., Milanova V., Grant SG, Hannon E., Rose SA, et al. Nature, 2014/02/13, Volume 506, Issue 7487, p.179-84, (2014) Read More / View Supplemental Materials
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Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.Dandapani, S., Germain AR, Jewett I., le Quement S., Marie JC, Muncipinto G., Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J., Kellar D., Siqueira-Neto JL, McKerrow JH, Kaiser M., Rodriguez A., Palmer MA, Foley M., Schreiber SL, and Munoz B. ACS medicinal chemistry letters, 2014/02/13, Volume 5, Issue 2, p.149-53, (2014) Read More / View Supplemental Materials
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Early Empiric Antibiotic Use in Preterm Infants Is Associated with Lower Bacterial Diversity and Higher Relative Abundance of Enterobacter.Greenwood, C., Morrow AL, Lagomarcino AJ, Altaye M., Taft DH, Yu Z., Newburg DS, Ward DV, and Schibler KR The Journal of pediatrics, 2014/02/13, (2014) Read More / View Supplemental Materials
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A polygenic burden of rare disruptive mutations in schizophrenia.Purcell, SM, Moran JL, Fromer M., Ruderfer D., Solovieff N., Roussos P., O'Dushlaine C., Chambert K., Bergen SE, Kähler A., Duncan L., Stahl E., Genovese G., Fernández E., Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E., Shakir K., et al. Nature, 2014/02/13, Volume 506, Issue 7487, p.185-90, (2014) Read More / View Supplemental Materials
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Zebrafish models of cerebrovascular disease.Walcott, BP, and Peterson RT Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014/02/12, (2014) Read More / View Supplemental Materials
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Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu.Leitsalu, L., Haller T., Esko T., Tammesoo ML, Alavere H., Snieder H., Perola M., Ng PC, Mägi R., Milani L., Fischer K., and Metspalu A. International journal of epidemiology, 2014/02/11, (2014) Read More / View Supplemental Materials
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Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization.Gorden, BH, Kim JH, Sarver AL, Frantz AM, Breen M., Lindblad-Toh K., O'Brien TD, Sharkey LC, Modiano JF, and Dickerson EB The American journal of pathology, 2014/02/11, (2014) Read More / View Supplemental Materials
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Nanog-Independent Reprogramming to iPSCs with Canonical Factors.Carter, AC, Davis-Dusenbery BN, Koszka K., Ichida JK, and Eggan K. Stem cell reports, 2014/02/11, Volume 2, Issue 2, p.119-26, (2014) Read More / View Supplemental Materials
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Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).Chhibber, A., Mefford J., Stahl EA, Pendergrass SA, Baldwin RM, Owzar K., Li M., Winer EP, Hudis CA, Zembutsu H., Kubo M., Nakamura Y., McLeod HL, Ratain MJ, Shulman LN, Ritchie MD, Plenge RM, Witte JS, and Kroetz DL The pharmacogenomics journal, 2014/02/11, (2014) Read More / View Supplemental Materials
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SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia.Puissant, A., Fenouille N., Alexe G., Pikman Y., Bassil CF, Mehta S., Du J., Kazi JU, Luciano F., Rönnstrand L., Kung AL, Aster J. C., Galinsky I., Stone RM, DeAngelo DJ, Hemann MT, and Stegmaier K. Cancer cell, 2014/02/10, Volume 25, Issue 2, p.226-42, (2014) Read More / View Supplemental Materials
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The antidepressant age.Hyman, SE Nature medicine, 2014/02/06, Volume 20, Issue 2, p.118-9, (2014) Read More / View Supplemental Materials