Scientific Publications

Search by Keyword(s)
Found 1604 results

Search Results

2013
Human systems immunology: Hypothesis-based modeling and unbiased data-driven approaches.Arazi, A., Pendergraft WF 3rd, Ribeiro RM, Perelson AS, and Hacohen N. Seminars in immunology, 2013/01/29, (2013) Read More / View Supplemental Materials
Abstract
Highly Recurrent TERT Promoter Mutations in Human Melanoma.Huang, FW, Hodis E., Xu MJ, Kryukov GV, Chin L., and Garraway LA Science (New York, N.Y.), 2013/01/24, (2013) Read More / View Supplemental Materials
Abstract
Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders.Lim, ET, Raychaudhuri S., Sanders SJ, Stevens C., Sabo A., Macarthur DG, Neale BM, Kirby A., Ruderfer DM, Fromer M., Lek M., Liu L., Flannick J., Ripke S., Nagaswamy U., Muzny D., Reid JG, Hawes A., Newsham I., Wu Y., et al. Neuron, 2013/01/23, Volume 77, Issue 2, p.235-42, (2013) Read More / View Supplemental Materials
Abstract
Using Whole-Exome Sequencing to Identify Inherited Causes of Autism.Yu, TW, Chahrour MH, Coulter ME, Jiralerspong S., Okamura-Ikeda K., Ataman B., Schmitz-Abe K., Harmin DA, Adli M., Malik AN, D'Gama AM, Lim ET, Sanders SJ, Mochida GH, Partlow JN, Sunu CM, Felie JM, Rodriguez J., Nasir RH, Ware J., et al. Neuron, 2013/01/23, Volume 77, Issue 2, p.259-273, (2013) Read More / View Supplemental Materials
Abstract
Ultranet: efficient solver for the sparse inverse covariance selection problem in gene network modeling.Järvstråt, L., Johansson M., Gullberg U., and Nilsson B. Bioinformatics (Oxford, England), 2013/01/21, (2013) Read More / View Supplemental Materials
Abstract
The genetic landscape of high-risk neuroblastoma.Pugh, TJ, Morozova O., Attiyeh EF, Asgharzadeh S., Wei JS, Auclair D., Carter SL, Cibulskis K., Hanna M., Kiezun A., Kim J., Lawrence MS, McKenna A., Pedamallu CS, Ramos AH, Shefler E., Sivachenko A., Sougnez C., Stewart C., Ally A., et al. Nature genetics, 2013/01/20, (2013) Read More / View Supplemental Materials
Abstract
Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.Brastianos, PK, Horowitz PM, Santagata S., Jones RT, McKenna A., Getz G., Ligon KL, Palescandolo E., Van Hummelen P., Ducar MD, Raza A., Macconaill LE, Louis DN, Hahn WC, Dunn IF, and Beroukhim R. Nature genetics, 2013/01/20, (2013) Read More / View Supplemental Materials
Abstract
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. viral proteinase slides along DNA to locate and process its substrates.Blainey, PC, Graziano V., Pérez-Berná AJ, McGrath WJ, Flint SJ, San Martín C., Xie XS, and Mangel WF The Journal of biological chemistry, 2013/01/18, Volume 288, Issue 3, p.2092-102, (2013) Read More / View Supplemental Materials
Abstract
ATG5 regulates plasma cell differentiation.Conway, KL, Kuballa P., Khor B., Zhang M., Shi HN, Virgin HW, and Xavier RJ Autophagy, 2013/01/17, Volume 9, Issue 4, (2013) Read More / View Supplemental Materials
Abstract
Prognostic Gene-Expression Signature for Patients with Hepatitis C-Related Early-Stage Cirrhosis.Hoshida, Y., Villanueva A., Sangiovanni A., Sole M., Hur C., Andersson KL, Chung RT, Gould J., Kojima K., Gupta S., Taylor B., Crenshaw A., Gabriel S., Minguez B., Iavarone M., Friedman SL, Colombo M., Llovet JM, and Golub T. R. Gastroenterology, 2013/01/17, (2013) Read More / View Supplemental Materials
Abstract
Mosaic copy number variation in schizophrenia.Ruderfer, DM, Chambert K., Moran J., Talkowski M., Chen ES, Gigek C., Gusella JF, Blackwood DH, Corvin A., Gurling HM, Hultman CM, Kirov G., Magnusson P., O'Donovan MC, Owen MJ, Pato C., St Clair D., Sullivan PF, Purcell SM, Sklar P., et al. European journal of human genetics : EJHG, 2013/01/16, (2013) Read More / View Supplemental Materials
Abstract
Rare, Low-Frequency, and Common Variants in the Protein-Coding Sequence of Biological Candidate Genes from GWASs Contribute to Risk of Rheumatoid Arthritis.Diogo, D., Kurreeman F., Stahl EA, Liao KP, Gupta N., Greenberg JD, Rivas MA, Hickey B., Flannick J., Thomson B., Guiducci C., Ripke S., Adzhubey I., Barton A., Kremer JM, Alfredsson L., Consortium of Rheumatology Researchers of North America, Rheumatoid Arthritis Consortium International, Sunyaev S., Martin J., et al. American journal of human genetics, 2013/01/10, Volume 92, Issue 1, p.15-27, (2013) Read More / View Supplemental Materials
Abstract
Complementary RNA and Protein Profiling Identifies Iron as a Key Regulator of Mitochondrial Biogenesis.Rensvold, JW, Ong SE, Jeevananthan A., Carr SA, Mootha VK, and Pagliarini DJ Cell reports, 2013/01/09, (2013) Read More / View Supplemental Materials
Abstract
Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation.Costello, M., Pugh TJ, Fennell TJ, Stewart C., Lichtenstein L., Meldrim JC, Fostel JL, Friedrich DC, Perrin D., Dionne D., Kim S., Gabriel SB, Lander E. S., Fisher S., and Getz G. Nucleic acids research, 2013/01/08, (2013) Read More / View Supplemental Materials
Abstract
The future is now: single-cell genomics of bacteria and archaea.Blainey, PC FEMS microbiology reviews, 2013/01/08, (2013) Read More / View Supplemental Materials
Abstract
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.Whittaker, SR, Theurillat JP, Van Allen E., Wagle N., Hsiao J., Cowley GS, Schadendorf D., Root DE, and Garraway LA Cancer discovery, 2013/01/03, (2013) Read More / View Supplemental Materials
Abstract
Multiplex Genome Engineering Using CRISPR/Cas Systems.Cong, L., Ran FA, Cox D., Lin S., Barretto R., Habib N., Hsu PD, Wu X., Jiang W., Marraffini LA, and Zhang F. Science (New York, N.Y.), 2013/01/03, (2013) Read More / View Supplemental Materials
Abstract
AUTOMATED QUANTIFICATION OF ZEBRAFISH TAIL DEFORMATION FOR HIGH-THROUGHPUT DRUG SCREENING.Ishaq, O., Negri J., Bray MA, Pacureanu A., Peterson RT, and Wählby C. Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging, 2013/01/01, p.902-905, (2013) Read More / View Supplemental Materials
Abstract
Computational prediction of lysine acetylation proteome-wide.Basu, A. Methods in molecular biology (Clifton, N.J.), 2013/01/01, Volume 981, p.127-36, (2013) Read More / View Supplemental Materials
Abstract
Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.Wang, C., Eessalu TE, Barth VN, Mitch CH, Wagner FF, Hong Y., Neelamegam R., Schroeder FA, Holson EB, Haggarty SJ, and Hooker JM American journal of nuclear medicine and molecular imaging, 2013/01/01, Volume 4, Issue 1, p.29-38, (2013) Read More / View Supplemental Materials
Abstract
Evolutionary principles of modular gene regulation in yeasts.Thompson, DA, Roy S., Chan M., Styczynsky MP, Pfiffner J., French C., Socha A., Thielke A., Napolitano S., Muller P., Kellis M., Konieczka JH, Wapinski I., and Regev A. eLife, 2013/01/01, Volume 2, p.e00603, (2013) Read More / View Supplemental Materials
Abstract
Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal.Daniels, R., Chang HH, Séne PD, Park DC, Neafsey DE, Schaffner SF, Hamilton EJ, Lukens AK, Van Tyne D., Mboup S., Sabeti PC, Ndiaye D., Wirth DF, Hartl DL, and Volkman SK PloS one, 2013/01/01, Volume 8, Issue 4, p.e60780, (2013) Read More / View Supplemental Materials
Abstract
Identification of Trypanosome proteins in plasma from African sleeping sickness patients infected with T. b. rhodesiense.Eyford, BA, Ahmad R., Enyaru JC, Carr SA, and Pearson TW PloS one, 2013/01/01, Volume 8, Issue 8, p.e71463, (2013) Read More / View Supplemental Materials
Abstract
Magnetic barcode assay for genetic detection of pathogens.Liong, M., Hoang AN, Chung J., Gural N., Ford CB, Min C., Shah RR, Ahmad R., Fernandez-Suarez M., Fortune SM, Toner M., Lee H., and Weissleder R. Nature communications, 2013/01/01, Volume 4, p.1752, (2013) Read More / View Supplemental Materials
Abstract
MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling.Plovanich, M., Bogorad RL, Sancak Y., Kamer KJ, Strittmatter L., Li AA, Girgis HS, Kuchimanchi S., De Groot J., Speciner L., Taneja N., Oshea J., Koteliansky V., and Mootha VK PloS one, 2013/01/01, Volume 8, Issue 2, p.e55785, (2013) Read More / View Supplemental Materials
Abstract
ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans.Youngsaye, W., Hartland CL, Morgan BJ, Ting A., Nag PP, Vincent B., Mosher CA, Bittker JA, Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. Beilstein journal of organic chemistry, 2013/01/01, Volume 9, p.1501-7, (2013) Read More / View Supplemental Materials
Abstract
Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry.Gillette, MA, and Carr SA Nature methods, 2013/01/01, Volume 10, Issue 1, p.28-34, (2013) Read More / View Supplemental Materials
Abstract
Reconstructing roma history from genome-wide data.Moorjani, P., Patterson N., Loh PR, Lipson M., Kisfali P., Melegh BI, Bonin M., Kádaši L., Rieß O., Berger B., Reich D., and Melegh B. PloS one, 2013/01/01, Volume 8, Issue 3, p.e58633, (2013) Read More / View Supplemental Materials
Abstract
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.Schroeder, FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J., Zhao WN, Reis S., Barker DD, Berry-Scott E., Kim SW, Clore EL, Hooker JM, Holson EB, Haggarty SJ, and Petryshen TL PloS one, 2013/01/01, Volume 8, Issue 8, p.e71323, (2013) Read More / View Supplemental Materials
Abstract
‘Big data’ from shrinking pathogen populations.Neafsey, DE Molecular ecology, 2013/01/01, Volume 22, Issue 2, p.271-2, (2013) Read More / View Supplemental Materials
Abstract
2012
How deep is deep enough for RNA-Seq profiling of bacterial transcriptomes?Haas, BJ, Chin M., Nusbaum C., Birren BW, and Livny J. BMC genomics, 2012/12/27, Volume 13, p.734, (2012) Read More / View Supplemental Materials
Abstract
ATARiS: Computational quantification of gene suppression phenotypes from multi-sample RNAi screens.Shao, DD, Tsherniak A., Gopal S., Weir BA, Tamayo P., Stransky N., Schumacher SE, Zack TI, Beroukhim R., Garraway LA, Margolin AA, Root DE, Hahn WC, and Mesirov J. P. Genome research, 2012/12/26, (2012) Read More / View Supplemental Materials
Abstract
Refined Preparation and Use of Anti-K- epsilon -GG Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments.Udeshi, ND, Svinkina T., Mertins P., Kuhn E., Mani D. R., Qiao JW, and Carr SA Molecular & cellular proteomics : MCP, 2012/12/24, (2012) Read More / View Supplemental Materials
Abstract
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.Lee, MN, Roy M., Ong SE, Mertins P., Villani AC, Li W., Dotiwala F., Sen J., Doench JG, Orzalli MH, Kramnik I., Knipe DM, Lieberman J., Carr SA, and Hacohen N. Nature immunology, 2012/12/23, Volume 14, Issue 2, p.179-85, (2012) Read More / View Supplemental Materials
Abstract
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.Efeyan, A., Zoncu R., Chang S., Gumper I., Snitkin H., Wolfson RL, Kirak O., Sabatini DD, and Sabatini DM Nature, 2012/12/23, (2012) Read More / View Supplemental Materials
Abstract
β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis.Rosenbluh, J., Nijhawan D., Cox AG, Li X., Schafer EJ, Zack TI, Wang X., Tsherniak A., Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F., Cowley GS, Root DE, Mesirov J. P., Beroukhim R., and Hahn WC Cell, 2012/12/21, Volume 151, Issue 7, p.1457-73, (2012) Read More / View Supplemental Materials
Abstract
The nature of confounding in genome-wide association studies.Vilhjálmsson, BJ, and Nordborg M. Nature reviews. Genetics, 2012/12/18, Volume 14, Issue 1, p.1-2, (2012) Read More / View Supplemental Materials
Abstract
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.Birsoy, K., Wang T., Possemato R., Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y., Peterson TR, Carette JE, Brummelkamp TR, Clish CB, and Sabatini DM Nature genetics, 2012/12/16, Volume 45, Issue 1, p.104-8, (2012) Read More / View Supplemental Materials
Abstract
Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.Barretina, J., Caponigro G., Stransky N., Venkatesan K., Margolin AA, Kim S., Wilson CJ, Lehár J., Kryukov GV, Sonkin D., Reddy A., Liu M., Murray L., Berger MF, Monahan JE, Morais P., Meltzer J., Korejwa A., Jané-Valbuena J., Mapa FA, et al. Nature, 2012/12/13, Volume 492, Issue 7428, p.290, (2012) Read More / View Supplemental Materials
The LRR and RING Domain Protein LRSAM1 Is an E3 Ligase Crucial for Ubiquitin-Dependent Autophagy of Intracellular Salmonella Typhimurium.Huett, A., Heath RJ, Begun J., Sassi SO, Baxt LA, Vyas JM, Goldberg MB, and Xavier RJ Cell host & microbe, 2012/12/13, Volume 12, Issue 6, p.778-90, (2012) Read More / View Supplemental Materials
Abstract
A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.Weïwer, M., Spoonamore J., Wei J., Guichard B., Ross NT, Masson K., Silkworth W., Dandapani S., Palmer M., Scherer CA, Stern AM, Schreiber SL, and Munoz B. ACS medicinal chemistry letters, 2012/12/13, Volume 3, Issue 12, p.1034-1038, (2012) Read More / View Supplemental Materials
Abstract
The ANK3 Bipolar Disorder Gene Regulates Psychiatric-Related Behaviors That Are Modulated by Lithium and Stress.Leussis, MP, Berry-Scott EM, Saito M., Jhuang H., De Haan G., Alkan O., Luce CJ, Madison JM, Sklar P., Serre T., Root DE, and Petryshen TL Biological psychiatry, 2012/12/10, (2012) Read More / View Supplemental Materials
Abstract
Differential analysis of gene regulation at transcript resolution with RNA-seq.Trapnell, C., Hendrickson DG, Sauvageau M., Goff L., Rinn JL, and Pachter L. Nature biotechnology, 2012/12/09, Volume 31, Issue 1, p.46-53, (2012) Read More / View Supplemental Materials
Abstract
Cellular alchemy and the golden age of reprogramming.Daley, GQ Cell, 2012/12/07, Volume 151, Issue 6, p.1151-4, (2012) Read More / View Supplemental Materials
Abstract
Differential relationship of DNA replication timing to different forms of human mutation and variation.Koren, A., Polak P., Nemesh J., Michaelson JJ, Sebat J., Sunyaev SR, and McCarroll SA American journal of human genetics, 2012/12/07, Volume 91, Issue 6, p.1033-40, (2012) Read More / View Supplemental Materials
Abstract
Disruption of a large intergenic noncoding RNA in subjects with neurodevelopmental disabilities.Talkowski, ME, Maussion G., Crapper L., Rosenfeld JA, Blumenthal I., Hanscom C., Chiang C., Lindgren A., Pereira S., Ruderfer D., Diallo AB, Lopez JP, Turecki G., Chen ES, Gigek C., Harris DJ, Lip V., An Y., Biagioli M., Macdonald ME, et al. American journal of human genetics, 2012/12/07, Volume 91, Issue 6, p.1128-34, (2012) Read More / View Supplemental Materials
Abstract
Integrative annotation of chromatin elements from ENCODE data.Hoffman, MM, Ernst J., Wilder SP, Kundaje A., Harris RS, Libbrecht M., Giardine B., Ellenbogen PM, Bilmes JA, Birney E., Hardison RC, Dunham I., Kellis M., and Noble WS Nucleic acids research, 2012/12/05, (2012) Read More / View Supplemental Materials
Abstract
Hits, leads and drugs against malaria through diversity-oriented synthesis.Dandapani, S., Comer E., Duvall JR, and Munoz B. Future medicinal chemistry, 2012/12/01, Volume 4, Issue 18, p.2279-94, (2012) Read More / View Supplemental Materials
Abstract
Targeted therapy for squamous cell lung cancer.Liao, RG, Watanabe H., Meyerson M., and Hammerman PS Lung cancer management, 2012/12/01, Volume 1, Issue 4, p.293-300, (2012) Read More / View Supplemental Materials
Abstract
Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset.Pasternak, O., Westin CF, Bouix S., Seidman LJ, Goldstein JM, Woo TU, Petryshen TL, Mesholam-Gately RI, McCarley RW, Kikinis R., Shenton ME, and Kubicki M. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012/11/28, Volume 32, Issue 48, p.17365-17372, (2012) Read More / View Supplemental Materials
Abstract
Microcephaly Gene Links Trithorax and REST/NRSF to Control Neural Stem Cell Proliferation and Differentiation.Yang, YJ, Baltus AE, Mathew RS, Murphy EA, Evrony GD, Gonzalez DM, Wang EP, Marshall-Walker CA, Barry BJ, Murn J., Tatarakis A., Mahajan MA, Samuels HH, Shi Y., Golden JA, Mahajnah M., Shenhav R., and Walsh CA Cell, 2012/11/21, Volume 151, Issue 5, p.1097-1112, (2012) Read More / View Supplemental Materials
Abstract
The Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans.Smith, JG, Avery CL, Evans DS, Nalls MA, Meng YA, Smith EN, Palmer C., Tanaka T., Mehra R., Butler AM, Young T., Buxbaum SG, Kerr KF, Berenson GS, Schnabel RB, Li G., Ellinor PT, Magnani JW, Chen W., Bis JC, et al. Circulation. Cardiovascular genetics, 2012/11/19, (2012) Read More / View Supplemental Materials
Abstract
From genetic discovery to future personalized health research.Palotie, A., Widén E., and Ripatti S. New biotechnology, 2012/11/16, (2012) Read More / View Supplemental Materials
Abstract
Expression Profiling of Archival Tumors for Long-term Health Studies.Waldron, L., Ogino S., Hoshida Y., Shima K., McCart Reed AE, Simpson PT, Baba Y., Nosho K., Segata N., Vargas AC, Cummings MC, Lakhani SR, Kirkner GJ, Giovannucci E., Quackenbush J., Golub T. R., Fuchs CS, Parmigiani G., and Huttenhower C. Clinical cancer research : an official journal of the American Association for Cancer Research, 2012/11/15, Volume 18, Issue 22, p.6136-6146, (2012) Read More / View Supplemental Materials
Abstract
Risk of Intracranial Hemorrhage With Protease-Activated Receptor-1 Antagonists.Falcone, GJ, Brouwers HB, and Rosand J. Stroke; a journal of cerebral circulation, 2012/11/15, (2012) Read More / View Supplemental Materials
Mitochondrial disorders as windows into an ancient organelle.Vafai, SB, and Mootha VK Nature, 2012/11/14, Volume 491, Issue 7424, p.374-383, (2012) Read More / View Supplemental Materials
Abstract
Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder.Lee, PH, Perlis RH, Jung JY, Byrne EM, Rueckert E., Siburian R., Haddad S., Mayerfeld CE, Heath AC, Pergadia ML, Madden PA, Boomsma DI, Penninx BW, Sklar P., Martin NG, Wray NR, Purcell SM, and Smoller JW Translational psychiatry, 2012/11/13, Volume 2, p.e184, (2012) Read More / View Supplemental Materials
Abstract
Will cholesteryl ester transfer protein inhibition succeed primarily by lowering low-density lipoprotein cholesterol?: insights from human genetics and clinical trials.Kathiresan, S. Journal of the American College of Cardiology, 2012/11/13, Volume 60, Issue 20, p.2049-52, (2012) Read More / View Supplemental Materials
Epidemiology. Emerging disease or diagnosis?Gire, SK, Stremlau M., Andersen KG, Schaffner SF, Bjornson Z., Rubins K., Hensley L., McCormick JB, Lander E. S., Garry RF, Happi C., and Sabeti PC Science (New York, N.Y.), 2012/11/09, Volume 338, Issue 6108, p.750-2, (2012) Read More / View Supplemental Materials
Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma.Jalili, A., Wagner C., Pashenkov M., Pathria G., Mertz KD, Widlund HR, Lupien M., Brunet JP, Golub T. R., Stingl G., Fisher DE, Ramaswamy S., and Wagner SN Journal of the National Cancer Institute, 2012/11/07, Volume 104, Issue 21, p.1673-9, (2012) Read More / View Supplemental Materials
Abstract
Whole Genome Pyrosequencing of Rare Hepatitis C Virus Genotypes Enhances Subtype Classification and Identification of Naturally Occurring Drug Resistance Variants.Newman, RM, Kuntzen T., Weiner B., Berical A., Charlebois P., Kuiken C., Murphy DG, Simmonds P., Bennett P., Lennon NJ, Birren BW, Zody MC, Allen TM, and Henn MR The Journal of infectious diseases, 2012/11/06, (2012) Read More / View Supplemental Materials
Abstract
Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability.Drier, Y., Lawrence MS, Carter SL, Stewart C., Gabriel SB, Lander E. S., Meyerson M., Beroukhim R., and Getz G. Genome research, 2012/11/02, (2012) Read More / View Supplemental Materials
Abstract
Bioinformatics for the human microbiome project.Gevers, D., Pop M., Schloss PD, and Huttenhower C. PLoS computational biology, 2012/11/01, Volume 8, Issue 11, p.e1002779, (2012) Read More / View Supplemental Materials
Computational analysis of noncoding RNAs.Washietl, S., Will S., Hendrix DA, Goff LA, Rinn JL, Berger B., and Kellis M. Wiley interdisciplinary reviews. RNA, 2012/11/01, Volume 3, Issue 6, p.759-78, (2012) Read More / View Supplemental Materials
Abstract
Informed conditioning on clinical covariates increases power in case-control association studies.Zaitlen, N., Lindström S., Pasaniuc B., Cornelis M., Genovese G., Pollack S., Barton A., Bickeböller H., Bowden DW, Eyre S., Freedman BI, Friedman DJ, Field JK, Groop L., Haugen A., Heinrich J., Henderson BE, Hicks PJ, Hocking LJ, Kolonel LN, et al. PLoS genetics, 2012/11/01, Volume 8, Issue 11, p.e1003032, (2012) Read More / View Supplemental Materials
Abstract
Interpreting noncoding genetic variation in complex traits and human disease.Ward, LD, and Kellis M. Nature biotechnology, 2012/11/01, Volume 30, Issue 11, p.1095-106, (2012) Read More / View Supplemental Materials
Abstract
LINKAGE TO THE MATING-TYPE LOCUS ACROSS THE GENUS MICROBOTRYUM: INSIGHTS INTO NONRECOMBINING CHROMOSOMES.Petit, E., Giraud T., de Vienne DM, Coelho MA, Aguileta G., Amselem J., Kreplak J., Poulain J., Gavory F., Wincker P., Young SK, Cuomo C., Perlin MH, and Hood ME Evolution; international journal of organic evolution, 2012/11/01, Volume 66, Issue 11, p.3519-3533, (2012) Read More / View Supplemental Materials
Abstract
Moving toward personalized medicine in castration-resistant prostate cancer.Van Allen, EM, and Pomerantz M. The Urologic clinics of North America, 2012/11/01, Volume 39, Issue 4, p.483-90, (2012) Read More / View Supplemental Materials
Abstract
Pencil and paper.Wong, B., and Kjægaard RS Nature methods, 2012/11/01, Volume 9, Issue 11, p.1037, (2012) Read More / View Supplemental Materials
Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes.Kleinnijenhuis, J., Quintin J., Preijers F., Joosten LA, Ifrim DC, Saeed S., Jacobs C., van Loenhout J., de Jong D., Stunnenberg HG, Xavier RJ, van der Meer JW, van Crevel R., and Netea MG Proceedings of the National Academy of Sciences of the United States of America, 2012/10/23, Volume 109, Issue 43, p.17537-42, (2012) Read More / View Supplemental Materials
Abstract
Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library.Gerard, B., O'Shea MW, Donckele E., Kesavan S., Akella LB, Xu H., Jacobsen EN, and Marcaurelle LA ACS combinatorial science, 2012/10/22, (2012) Read More / View Supplemental Materials
Abstract
Oligodendrocyte Regeneration after Neonatal Hypoxia Requires FoxO1-Mediated p27Kip1 Expression.Jablonska, B., Scafidi J., Aguirre A., Vaccarino F., Nguyen V., Borok E., Horvath TL, Rowitch DH, and Gallo V. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012/10/17, Volume 32, Issue 42, p.14775-14793, (2012) Read More / View Supplemental Materials
Abstract
Integrative functional genomics identifies RINT1 as a novel GBM oncogene.Quayle, SN, Chheda MG, Shukla SA, Wiedemeyer R., Tamayo P., Dewan RW, Zhuang L., Huang-Hobbs E., Haidar S., Xiao Y., Ligon KL, Hahn WC, and Chin L. Neuro-oncology, 2012/10/16, (2012) Read More / View Supplemental Materials
Abstract
The limitations of simple gene set enrichment analysis assuming gene independence.Tamayo, P., Steinhardt G., Liberzon A., and Mesirov J. P. Statistical methods in medical research, 2012/10/14, (2012) Read More / View Supplemental Materials
Abstract
Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.Dockendorff, C., Nagiec MM, Weïwer M., Buhrlage S., Ting A., Nag PP, Germain A., Kim HJ, Youngsaye W., Scherer C., Bennion M., Xue L., Stanton BZ, Lewis TA, Macpherson L., Palmer M., Foley MA, Perez JR, and Schreiber SL ACS medicinal chemistry letters, 2012/10/11, Volume 3, Issue 10, p.808-813, (2012) Read More / View Supplemental Materials
Abstract
Revolution stalled.Hyman, SE Science translational medicine, 2012/10/10, Volume 4, Issue 155, p.155cm11, (2012) Read More / View Supplemental Materials
Abstract
Discovery and Statistical Genotyping of Copy-Number Variation from Whole-Exome Sequencing Depth.Fromer, M., Moran JL, Chambert K., Banks E., Bergen SE, Ruderfer DM, Handsaker RE, McCarroll SA, O'Donovan MC, Owen MJ, Kirov G., Sullivan PF, Hultman CM, Sklar P., and Purcell SM American journal of human genetics, 2012/10/05, Volume 91, Issue 4, p.597-607, (2012) Read More / View Supplemental Materials
Abstract
Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling.Boyle, P., Clement K., Gu H., Smith ZD, Ziller M., Fostel JL, Holmes L., Meldrim J., Kelley F., Gnirke A., and Meissner A. Genome biology, 2012/10/03, Volume 13, Issue 10, p.R92, (2012) Read More / View Supplemental Materials
Abstract
H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions.Ku, M., Jaffe JD, Koche RP, Rheinbay E., Endoh M., Koseki H., Carr SA, and Bernstein BE Genome biology, 2012/10/03, Volume 13, Issue 10, p.R85, (2012) Read More / View Supplemental Materials
Abstract
Autoimmunity: insights from human genomics.Raychaudhuri, S., and Rich SS Current opinion in immunology, 2012/10/01, Volume 24, Issue 5, p.513-5, (2012) Read More / View Supplemental Materials
Coordinating GWAS results with gene expression in a systems immunologic paradigm in autoimmunity.Stranger, BE, and De Jager PL Current opinion in immunology, 2012/10/01, Volume 24, Issue 5, p.544-51, (2012) Read More / View Supplemental Materials
Abstract
The Date of Interbreeding between Neandertals and Modern Humans.Sankararaman, S., Patterson N., Li H., Pääbo S., and Reich D. PLoS genetics, 2012/10/01, Volume 8, Issue 10, p.e1002947, (2012) Read More / View Supplemental Materials
Abstract
p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation.Conway, KL, Goel G., Sokol H., Manocha M., Mizoguchi E., Terhorst C., Bhan AK, Gardet A., and Xavier RJ Journal of immunology (Baltimore, Md. : 1950), 2012/10/01, Volume 189, Issue 7, p.3631-40, (2012) Read More / View Supplemental Materials
Abstract
Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells.Carmody, LC, Germain AR, VerPlank L., Nag PP, Muñoz B., Perez JR, and Palmer MA Journal of biomolecular screening, 2012/10/01, Volume 17, Issue 9, p.1204-10, (2012) Read More / View Supplemental Materials
Abstract
QT Interval and Long-Term Mortality Risk in the Framingham Heart Study.Noseworthy, PA, Peloso GM, Hwang SJ, Larson MG, Levy D., O'Donnell CJ, and Newton-Cheh C. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2012/10/01, Volume 17, Issue 4, p.340-348, (2012) Read More / View Supplemental Materials
Abstract
Shotgun protein sequencing with meta-contig assembly.Guthals, A., Clauser KR, and Bandeira N. Molecular & cellular proteomics : MCP, 2012/10/01, Volume 11, Issue 10, p.1084-96, (2012) Read More / View Supplemental Materials
Abstract
What have we learned from six years of GWAS in autoimmune diseases, and what is next?Hu, X., and Daly M. Current opinion in immunology, 2012/10/01, Volume 24, Issue 5, p.571-5, (2012) Read More / View Supplemental Materials
Abstract
An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.Ottoboni, L., Keenan BT, Tamayo P., Kuchroo M., Mesirov J. P., Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, and De Jager PL Science translational medicine, 2012/09/26, Volume 4, Issue 153, p.153ra131, (2012) Read More / View Supplemental Materials
Abstract
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.Adams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/09/18, Volume 109, Issue 38, p.15115-20, (2012) Read More / View Supplemental Materials
Abstract
Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.Sankaran, VG, Ludwig LS, Sicinska E., Xu J., Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y., Orkin SH, Sicinski P., Lander E. S., and Lodish HF Genes & development, 2012/09/15, Volume 26, Issue 18, p.2075-87, (2012) Read More / View Supplemental Materials
Abstract
A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals.Garber, M., Yosef N., Goren A., Raychowdhury R., Thielke A., Guttman M., Robinson J., Minie B., Chevrier N., Itzhaki Z., Blecher-Gonen R., Bornstein C., Amann-Zalcenstein D., Weiner A., Friedrich D., Meldrim J., Ram O., Cheng C., Gnirke A., Fisher S., et al. Molecular cell, 2012/09/14, Volume 47, Issue 5, p.810-22, (2012) Read More / View Supplemental Materials
Abstract
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.Imielinski, M., Berger AH, Hammerman PS, Hernandez B., Pugh TJ, Hodis E., Cho J., Sivachenko A., Sougnez C., Auclair D., Lawrence MS, Stojanov P., Cibulskis K., Sharifnia T., Greulich H., Banerji S., Zander T., Thompson K., Winckler W., Kwiatkowski D., et al. Cell, 2012/09/14, Volume 150, Issue 6, p.1107-20, (2012) Read More / View Supplemental Materials
Abstract
De novo assembly of highly diverse viral populations.Yang, X., Charlebois P., Gnerre S., Coole MG, Lennon NJ, Levin JZ, Qu J., Ryan EM, Zody MC, and Henn MR BMC genomics, 2012/09/13, Volume 13, p.475, (2012) Read More / View Supplemental Materials
Abstract
Integrative Analysis Reveals an Outcome-Associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B Cell Lymphoma.Monti, S., Chapuy B., Takeyama K., Rodig SJ, Hao Y., Yeda KT, Inguilizian H., Mermel C., Currie T., Dogan A., Kutok JL, Beroukhim R., Neuberg D., Habermann TM, Getz G., Kung AL, Golub T. R., and Shipp M. A. Cancer cell, 2012/09/11, Volume 22, Issue 3, p.359-72, (2012) Read More / View Supplemental Materials
Abstract
Whole Exome Sequencing Reveals a Novel Mutation in CUL7 in a Patient with an Undiagnosed Growth Disorder.Dauber, A., Stoler J., Hechter E., Safer J., and Hirschhorn JN The Journal of pediatrics, 2012/09/10, (2012) Read More / View Supplemental Materials
Abstract
Comprehensive genomic characterization of squamous cell lung cancers.The Cancer Genome Atlas Research, Network, institution.)(Participants are arranged by area of contribution and then by, Genome sequencing centres: Broad Institute, Hammerman PS, Lawrence MS, Voet D., Jing R., Cibulskis K., Sivachenko A., Stojanov P., McKenna A., Lander E. S., Gabriel S., Getz G., Sougnez C., Imielinski M., Helman E., Hernandez B., Pho NH, Meyerson M., et al. Nature, 2012/09/09, (2012) Read More / View Supplemental Materials
Abstract
Complete viral RNA genome sequencing of ultra-low copy samples by sequence-independent amplification.Malboeuf, CM, Yang X., Charlebois P., Qu J., Berlin AM, Casali M., Pesko KN, Boutwell CL, Devincenzo JP, Ebel GD, Allen TM, Zody MC, Henn MR, and Levin JZ Nucleic acids research, 2012/09/08, (2012) Read More / View Supplemental Materials
Abstract
Mechanisms and evolution of virulence in oomycetes.Jiang, RH, and Tyler BM Annual review of phytopathology, 2012/09/08, Volume 50, p.295-318, (2012) Read More / View Supplemental Materials
Abstract
Ancient Admixture in Human History.Patterson, NJ, Moorjani P., Luo Y., Mallick S., Rohland N., Zhan Y., Genschoreck T., Webster T., and Reich D. Genetics, 2012/09/07, (2012) Read More / View Supplemental Materials
Abstract
Burden of rare sarcomere gene variants in the framingham and jackson heart study cohorts.Bick, AG, Flannick J., Ito K., Cheng S., Vasan RS, Parfenov MG, Herman DS, Depalma SR, Gupta N., Gabriel SB, Funke BH, Rehm HL, Benjamin EJ, Aragam J., Taylor HA Jr, Fox ER, Newton-Cheh C., Kathiresan S., O'Donnell CJ, Wilson JG, et al. American journal of human genetics, 2012/09/07, Volume 91, Issue 3, p.513-9, (2012) Read More / View Supplemental Materials
Abstract