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2016
Transforming Clinical Data into Actionable Prognosis Models: Machine-Learning Framework and Field-Deployable App to Predict Outcome of Ebola Patients.Colubri, A., Silver T., Fradet T., Retzepi K., Fry B., and Sabeti P. PLoS neglected tropical diseases, 2016/03/01, Volume 10, Issue 3, p.e0004549, (2016) Read More / View Supplemental Materials
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Viral Packaging and Cell Culture for CRISPR-Based Screens.Wang, T., Lander E. S., and Sabatini DM Cold Spring Harbor protocols, 2016/03/01, Volume 2016, Issue 3, p.pdb.prot090811, (2016) Read More / View Supplemental Materials
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Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients.Schwieler, L., Samuelsson M., Frye MA, Bhat M., Schuppe-Koistinen I., Jungholm O., Johansson AG, Landén M., Sellgren CM, and Erhardt S. Journal of neuroinflammation, 2016/02/29, Volume 13, Issue 1, p.51, (2016) Read More / View Supplemental Materials
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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.Yu, C., Mannan AM, Yvone GM, Ross KN, Zhang YL, Marton MA, Taylor BR, Crenshaw A., Gould JZ, Tamayo P., Weir BA, Tsherniak A., Wong B., Garraway LA, Shamji AF, Palmer MA, Foley MA, Winckler W., Schreiber SL, Kung AL, et al. Nature biotechnology, 2016/02/29, (2016) Read More / View Supplemental Materials
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New Regulatory Roles of Galectin-3 in the High-affinity IgE Receptor Signaling.Bambouskova, M., Polakovicova I., Halova I., Goel G., Draberova L., Bugajev V., Doan A., Utekal P., Gardet A., Xavier RJ, and Draber P. Molecular and cellular biology, 2016/02/29, (2016) Read More / View Supplemental Materials
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Strictly co-isogenic C57BL/6J-Prnp-/- mice: A rigorous resource for prion science.Nuvolone, M., Hermann M., Sorce S., Russo G., Tiberi C., Schwarz P., Minikel E., Sanoudou D., Pelczar P., and Aguzzi A. The Journal of experimental medicine, 2016/02/29, (2016) Read More / View Supplemental Materials
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Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma.Tokunaga, R., Imamura Y., Nakamura K., Ishimoto T., Nakagawa S., Miyake K., Nakaji Y., Tsuda Y., Iwatsuki M., Baba Y., Sakamoto Y., Miyamoto Y., Saeki H., Yoshida N., Oki E., Watanabe M., Oda Y., Bass AJ, Maehara Y., and Baba H. Oncotarget, 2016/02/27, (2016) Read More / View Supplemental Materials
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MicroRNA and gene expression changes in unruptured human cerebral aneurysms.Bekelis, K., Kerley-Hamilton JS, Teegarden A., Tomlinson CR, Kuintzle R., Simmons N., Singer RJ, Roberts DW, Kellis M., and Hendrix DA Journal of neurosurgery, 2016/02/26, p.1-10, (2016) Read More / View Supplemental Materials
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A polyalanine peptide derived from polar fish with anti-infectious activities.Cardoso, MH, Ribeiro SM, Nolasco DO, de la Fuente-Núñez C., Felício MR, Gonçalves S., Matos CO, Liao LM, Santos NC, Hancock RE, Franco OL, and Migliolo L. Scientific reports, 2016/02/26, Volume 6, p.21385, (2016) Read More / View Supplemental Materials
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VariantBam: filtering and profiling of next-generational sequencing data using region-specific rules.Wala, J., Zhang CZ, Meyerson M., and Beroukhim R. Bioinformatics (Oxford, England), 2016/02/26, (2016) Read More / View Supplemental Materials
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EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.Olenchock, BA, Moslehi J., Baik AH, Davidson SM, Williams J., Gibson WJ, Pierce KA, Miller CM, Hanse EA, Kelekar A., Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, and Kaelin WG Jr Cell, 2016/02/25, Volume 164, Issue 5, p.884-95, (2016) Read More / View Supplemental Materials
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Hypoxia as a therapy for mitochondrial disease.Jain, IH, Zazzeron L., Goli R., Alexa K., Schatzman-Bone S., Dhillon H., Goldberger O., Peng J., Shalem O., Sanjana NE, Zhang F., Goessling W., Zapol WM, and Mootha VK Science (New York, N.Y.), 2016/02/25, (2016) Read More / View Supplemental Materials
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Reducing Cardiovascular Risk Using Genomic Information in the Era of Precision Medicine.Natarajan, P., and O'Donnell CJ Circulation, 2016/02/25, (2016) Read More / View Supplemental Materials
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Buying cures versus renting health: Financing health care with consumer loans.Montazerhodjat, V., Weinstock DM, and Lo AW Science translational medicine, 2016/02/24, Volume 8, Issue 327, p.327ps6, (2016) Read More / View Supplemental Materials
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Acute Metabolic Influences on the Natriuretic Peptide System in Humans.Arora, P., Wu C., Hamid T., Arora G., Agha O., Allen K., Tainsh RE, Hu D., Ryan RA, Domian IJ, Buys ES, Bloch DB, Prabhu SD, Bloch KD, Newton-Cheh C., and Wang TJ Journal of the American College of Cardiology, 2016/02/23, Volume 67, Issue 7, p.804-12, (2016) Read More / View Supplemental Materials
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Polygenic risk for type 2 diabetes mellitus among individuals with psychosis and their relatives.Padmanabhan, JL, Nanda P., Tandon N., Mothi SS, Bolo N., McCarroll S., Clementz BA, Gershon ES, Pearlson GD, Sweeney JA, Tamminga CA, and Keshavan MS Journal of psychiatric research, 2016/02/23, Volume 77, p.52-58, (2016) Read More / View Supplemental Materials
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Precision medicine for advanced prostate cancer.Mullane, SA, and Van Allen EM Current opinion in urology, 2016/02/23, (2016) Read More / View Supplemental Materials
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Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.Horikoshi, M., Pasquali L., Wiltshire S., Huyghe JR, Mahajan A., Asimit JL, Ferreira T., Locke AE, Robertson NR, Wang X., Sim X., Fujita H., Hara K., Young R., Zhang W., Choi S., Chen H., Kaur I., Takeuchi F., Fontanillas P., et al. Human molecular genetics, 2016/02/23, (2016) Read More / View Supplemental Materials
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Chemoproteomic profiling of host and pathogen enzymes active in cholera.Hatzios, SK, Abel S., Martell J., Hubbard T., Sasabe J., Munera D., Clark L., Bachovchin DA, Qadri F., Ryan ET, Davis BM, Weerapana E., and Waldor MK Nature chemical biology, 2016/02/22, (2016) Read More / View Supplemental Materials
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Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas.Eising, E., Huisman SM, Mahfouz A., Vijfhuizen LS, Anttila V., Winsvold BS, Kurth T., Ikram MA, Freilinger T., Kaprio J., Boomsma DI, van Duijn CM, Järvelin MR, Zwart JA, Quaye L., Strachan DP, Kubisch C., Dichgans M., Davey Smith G., Stefansson K., et al. Human genetics, 2016/02/22, (2016) Read More / View Supplemental Materials
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Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.Ma, L., Chen Z., Huang da W., Kutty G., Ishihara M., Wang H., Abouelleil A., Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., FitzGerald M., Gogineni E., Goldberg JM, Handley G., Hu X., Huber C., Jiao X., et al. Nature communications, 2016/02/22, Volume 7, p.10740, (2016) Read More / View Supplemental Materials
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Natural variation in non-coding regions underlying phenotypic diversity in budding yeast.Salinas, F., de Boer CG, Abarca V., García V., Cuevas M., Araos S., Larrondo LF, Martínez C., and Cubillos FA Scientific reports, 2016/02/22, Volume 6, p.21849, (2016) Read More / View Supplemental Materials
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Nonparametric estimation of the rediscovery rate.Lee, D., Ganna A., Pawitan Y., and Lee W. Statistics in medicine, 2016/02/22, (2016) Read More / View Supplemental Materials
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Recurring exon deletions in the HP (haptoglobin) gene contribute to lower blood cholesterol levels.Boettger, LM, Salem RM, Handsaker RE, Peloso GM, Kathiresan S., Hirschhorn JN, and McCarroll SA Nature genetics, 2016/02/22, (2016) Read More / View Supplemental Materials
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Transcriptome-scale RNase-footprinting of RNA-protein complexes.Ji, Z., Song R., Huang H., Regev A., and Struhl K. Nature biotechnology, 2016/02/22, (2016) Read More / View Supplemental Materials
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A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping.Han, B., Duong D., Sul JH, de Bakker PI, Eskin E., and Raychaudhuri S. Human molecular genetics, 2016/02/21, (2016) Read More / View Supplemental Materials
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Testing the Role of Predicted Gene Knockouts in Human Anthropometric Trait Variation.Lessard, S., Manning AK, Low-Kam C., Auer PL, Giri A., Graff M., Schurmann C., Yaghootkar H., Luan J., Esko T., Karaderi T., NHLBI GO Exome Sequence Project, GOT2D, T2D-GENES, GIANT Consortium, Bottinger EP, Lu Y., Carlson C., Caulfield M., Dubé MP, et al. Human molecular genetics, 2016/02/21, (2016) Read More / View Supplemental Materials
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Developing a system that can automatically detect health changes using transfer times of older adults.Baldewijns, G., Luca S., Vanrumste B., and Croonenborghs T. BMC medical research methodology, 2016/02/20, Volume 16, Issue 1, p.23, (2016) Read More / View Supplemental Materials
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Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors.Ordulu, Z., Nucci MR, Dal Cin P., Hollowell ML, Otis CN, Hornick JL, Park PJ, Kim TM, Quade BJ, and Morton CC Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2016/02/19, (2016) Read More / View Supplemental Materials
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An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.Wagner, FF, Lundh M., Kaya T., McCarren P., Zhang YL, Chattopadhyay S., Gale JP, Galbo T., Fisher SL, Meier BC, Vetere A., Richardson S., Morgan NG, Christensen DP, Gilbert TJ, Hooker JM, Leroy M., Walpita D., Mandrup-Poulsen T., Wagner BK, et al. ACS chemical biology, 2016/02/19, Volume 11, Issue 2, p.363-74, (2016) Read More / View Supplemental Materials
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Surprises From Genetic Analyses of Lipid Risk Factors for Atherosclerosis.Musunuru, K., and Kathiresan S. Circulation research, 2016/02/19, Volume 118, Issue 4, p.579-85, (2016) Read More / View Supplemental Materials
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Early-branching gut fungi possess a large, comprehensive array of biomass-degrading enzymes.Solomon, KV, Haitjema CH, Henske JK, Gilmore SP, Borges-Rivera D., Lipzen A., Brewer HM, Purvine SO, Wright AT, Theodorou MK, Grigoriev IV, Regev A., Thompson DA, and O'Malley MA Science (New York, N.Y.), 2016/02/18, (2016) Read More / View Supplemental Materials
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Visualizing antibody affinity maturation in germinal centers.Tas, JM, Mesin L., Pasqual G., Targ S., Jacobsen JT, Mano YM, Chen CS, Weill JC, Reynaud CA, Browne EP, Meyer-Hermann M., and Victora GD Science (New York, N.Y.), 2016/02/18, (2016) Read More / View Supplemental Materials
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Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.Koyama, S., Akbay EA, Li YY, Herter-Sprie GS, Buczkowski KA, Richards W. G., Gandhi L., Redig AJ, Rodig SJ, Asahina H., Jones RE, Kulkarni MM, Kuraguchi M., Palakurthi S., Fecci PE, Johnson B. E., Janne PA, Engelman JA, Gangadharan SP, Costa DB, et al. Nature communications, 2016/02/17, Volume 7, p.10501, (2016) Read More / View Supplemental Materials
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Adult restoration of Shank3 expression rescues selective autistic-like phenotypes.Mei, Y., Monteiro P., Zhou Y., Kim JA, Gao X., Fu Z., and Feng G. Nature, 2016/02/17, (2016) Read More / View Supplemental Materials
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Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice.Zhang, Q., Gao X., Li C., Feliciano C., Wang D., Zhou D., Mei Y., Monteiro P., Anand M., Itohara S., Dong X., Fu Z., and Feng G. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016/02/17, Volume 36, Issue 7, p.2247-60, (2016) Read More / View Supplemental Materials
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Molecular features of cellular reprogramming and development.Smith, ZD, Sindhu C., and Meissner A. Nature reviews. Molecular cell biology, 2016/02/17, (2016) Read More / View Supplemental Materials
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Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.Ruiz-Canela, M., Toledo E., Clish CB, Hruby A., Liang L., Salas-Salvadó J., Razquin C., Corella D., Estruch R., Ros E., Fitó M., Gómez-Gracia E., Arós F., Fiol M., Lapetra J., Serra-Majem L., Martínez-González MA, and Hu FB Clinical chemistry, 2016/02/17, (2016) Read More / View Supplemental Materials
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Reclassification of genetic-based risk predictions as GWAS data accumulate.Krier, J., Barfield R., Green RC, and Kraft P. Genome medicine, 2016/02/17, Volume 8, Issue 1, p.20, (2016) Read More / View Supplemental Materials
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Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes.Yassour, M., Lim MY, Yun HS, Tickle TL, Sung J., Song YM, Lee K., Franzosa EA, Morgan XC, Gevers D., Lander E. S., Xavier RJ, Birren BW, Ko G., and Huttenhower C. Genome medicine, 2016/02/17, Volume 8, Issue 1, p.17, (2016) Read More / View Supplemental Materials
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Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model.Obaldía Iii, N., Dow GS, Gerena L., Kyle D., Otero W., Mantel PY, Baro N., Daniels R., Mukherjee A., Childs LM, Buckee C., Duraisingh MT, Volkman SK, Wirth DF, and Marti M. Scientific reports, 2016/02/16, Volume 6, p.21216, (2016) Read More / View Supplemental Materials
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Response to Letter Regarding Article, "Trauma Exposure and Posttraumatic Stress Disorder Symptoms Predict Onset of Cardiovascular Events in Women".Sumner, JA, Kubzansky LD, Elkind MS, Roberts AL, Agnew-Blais J., Chen Q., Cerdá M., Rexrode KM, Rich-Edwards JW, Spiegelman D., Suglia SF, Rimm EB, and Koenen KC Circulation, 2016/02/16, Volume 133, Issue 7, p.e401-2, (2016) Read More / View Supplemental Materials
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.Lissanu Deribe, Y., Shi Y., Rai K., Nezi L., Amin SB, Wu CC, Akdemir KC, Mahdavi M., Peng Q., Chang QE, Hornigold K., Arold ST, Welch HC, Garraway LA, and Chin L. Proceedings of the National Academy of Sciences of the United States of America, 2016/02/16, (2016) Read More / View Supplemental Materials
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Type 2 Diabetes Genetic Predisposition, Obesity, and All-Cause Mortality Risk in the U.S.: A Multiethnic Analysis.Leong, A., Porneala B., Dupuis J., Florez JC, and Meigs JB Diabetes care, 2016/02/16, (2016) Read More / View Supplemental Materials
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Widespread RNA binding by chromatin-associated proteins.Hendrickson, DG, Kelley DR, Tenen D., Bernstein B., and Rinn JL Genome biology, 2016/02/16, Volume 17, Issue 1, p.28, (2016) Read More / View Supplemental Materials
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Cannabinoid receptor signaling regulates liver development and metabolism.Liu, LY, Alexa K., Cortes M., Schatzman-Bone S., Kim AJ, Mukhopadhyay B., Cinar R., Kunos G., North TE, and Goessling W. Development (Cambridge, England), 2016/02/15, Volume 143, Issue 4, p.609-22, (2016) Read More / View Supplemental Materials
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Gene expression inference with deep learning.Chen, Y., Li Y., Narayan R., Subramanian A., and Xie X. Bioinformatics (Oxford, England), 2016/02/11, (2016) Read More / View Supplemental Materials
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Impact of common diabetes risk variant in MTNR1B on sleep, circadian and melatonin physiology.Lane, JM, Chang AM, Bjonnes AC, Aeschbach D., Anderson C., Cade BE, Cain SW, Czeisler CA, Gharib SA, Gooley JJ, Gottlieb DJ, Grant SF, Klerman EB, Lauderdale DS, Lockley SW, Munch M., Patel S., Punjabi NM, Rajaratnam SM, Rueger M., et al. Diabetes, 2016/02/11, (2016) Read More / View Supplemental Materials
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Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation.Kim, N., Cho A., Watanabe H., Choi YL, Aziz M., Kassner M., Joung JG, Park AK, Francis JM, Bae JS, Ahn SM, Kim KM, Park JO, Park WY, Ahn MJ, Park K., Koo J., Yin HH, and Cho J. Oncotarget, 2016/02/11, (2016) Read More / View Supplemental Materials
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MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.Kryukov, GV, Wilson FH, Ruth JR, Paulk J., Tsherniak A., Marlow SE, Vazquez F., Weir BA, Fitzgerald ME, Tanaka M., Bielski CM, Scott JM, Dennis C., Cowley GS, Boehm JS, Root DE, Golub T. R., Clish CB, Bradner JE, Hahn WC, et al. Science (New York, N.Y.), 2016/02/11, (2016) Read More / View Supplemental Materials
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Oncologists' and cancer patients' views on whole-exome sequencing and incidental findings: results from the CanSeq study.Gray, SW, Park ER, Najita J., Martins Y., Traeger L., Bair E., Gagne J., Garber J., Jänne PA, Lindeman N., Lowenstein C., Oliver N., Van Allen EM, Wagle N., Garraway L., and Joffe S. Genetics in medicine : official journal of the American College of Medical Genetics, 2016/02/11, (2016) Read More / View Supplemental Materials
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Schizophrenia risk from complex variation of complement component 4.Sekar, A., Bialas AR, de Rivera H., Davis A., Hammond TR, Kamitaki N., Tooley K., Presumey J., Baum M., Van Doren V., Genovese G., Rose SA, Handsaker RE, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Daly M. J., Carroll MC, Stevens B., and McCarroll SA Nature, 2016/02/11, Volume 530, Issue 7589, p.177-83, (2016) Read More / View Supplemental Materials
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Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors.Huang, F., Goyal N., Sullivan K., Hanamshet K., Patel M., Mazina OM, Wang CX, An WF, Spoonamore J., Metkar S., Emmitte KA, Cocklin S., Skorski T., and Mazin AV Nucleic acids research, 2016/02/11, (2016) Read More / View Supplemental Materials
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Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later.Spartano, NL, Himali JJ, Beiser AS, Lewis GD, Decarli C., Vasan RS, and Seshadri S. Neurology, 2016/02/10, (2016) Read More / View Supplemental Materials
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Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.Wong, AS, Choi GC, Cui CH, Pregernig G., Milani P., Adam M., Perli SD, Kazer SW, Gaillard A., Hermann M., Shalek AK, Fraenkel E., and Lu TK Proceedings of the National Academy of Sciences of the United States of America, 2016/02/10, (2016) Read More / View Supplemental Materials
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Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium.Finak, G., Langweiler M., Jaimes M., Malek M., Taghiyar J., Korin Y., Raddassi K., Devine L., Obermoser G., Pekalski ML, Pontikos N., Diaz A., Heck S., Villanova F., Terrazzini N., Kern F., Qian Y., Stanton R., Wang K., Brandes A., et al. Scientific reports, 2016/02/10, Volume 6, p.20686, (2016) Read More / View Supplemental Materials
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Structure and Engineering of Francisella novicida Cas9.Hirano, H., Gootenberg JS, Horii T., Abudayyeh OO, Kimura M., Hsu PD, Nakane T., Ishitani R., Hatada I., Zhang F., Nishimasu H., and Nureki O. Cell, 2016/02/10, (2016) Read More / View Supplemental Materials
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Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer.Strickland, KC, Howitt BE, Shukla SA, Rodig S., Ritterhouse LL, Liu JF, Garber JE, Chowdhury D., Wu CJ, D'Andrea AD, Matulonis UA, and Konstantinopoulos PA Oncotarget, 2016/02/09, (2016) Read More / View Supplemental Materials
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Genomic insights into the Ixodes scapularis tick vector of Lyme disease.Gulia-Nuss, M., Nuss AB, Meyer JM, Sonenshine DE, Roe RM, Waterhouse RM, Sattelle DB, de la Fuente J., Ribeiro JM, Megy K., Thimmapuram J., Miller JR, Walenz BP, Koren S., Hostetler JB, Thiagarajan M., Joardar VS, Hannick LI, Bidwell S., Hammond MP, et al. Nature communications, 2016/02/09, Volume 7, p.10507, (2016) Read More / View Supplemental Materials
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Metabolite profiles of diabetes incidence and intervention response in the Diabetes Prevention Program.Walford, GA, Ma Y., Clish C., Florez JC, Wang TJ, Gerszten RE, and Diabetes Prevention Program Research Group Diabetes, 2016/02/09, (2016) Read More / View Supplemental Materials
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Reply to Almécija: A new direction for reconstructing our last common ancestor with chimpanzees.Young, NM, Capellini TD, Roach NT, and Alemseged Z. Proceedings of the National Academy of Sciences of the United States of America, 2016/02/09, (2016) Read More / View Supplemental Materials
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer.Beltran, H., Prandi D., Mosquera JM, Benelli M., Puca L., Cyrta J., Marotz C., Giannopoulou E., Chakravarthi BV, Varambally S., Tomlins SA, Nanus DM, Tagawa ST, Van Allen EM, Elemento O., Sboner A., Garraway LA, Rubin MA, and Demichelis F. Nature medicine, 2016/02/08, (2016) Read More / View Supplemental Materials
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Integrative approaches for large-scale transcriptome-wide association studies.Gusev, A., Ko A., Shi H., Bhatia G., Chung W., Penninx BW, Jansen R., de Geus EJ, Boomsma DI, Wright FA, Sullivan PF, Nikkola E., Alvarez M., Civelek M., Lusis AJ, Lehtimäki T., Raitoharju E., Kähönen M., Seppälä I., Raitakari OT, et al. Nature genetics, 2016/02/08, (2016) Read More / View Supplemental Materials
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Molecular sled sequences are common in mammalian proteins.Xiong, K., and Blainey PC Nucleic acids research, 2016/02/08, (2016) Read More / View Supplemental Materials
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Advances in understanding erythropoiesis: evolving perspectives.Nandakumar, SK, Ulirsch JC, and Sankaran VG British journal of haematology, 2016/02/05, (2016) Read More / View Supplemental Materials
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Evidence for Unresolved γ-Ray Point Sources in the Inner Galaxy.Lee, SK, Lisanti M., Safdi BR, Slatyer TR, and Xue W. Physical review letters, 2016/02/05, Volume 116, Issue 5, p.051103, (2016) Read More / View Supplemental Materials
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The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease.Keum, JW, Shin A., Gillis T., Mysore JS, Abu Elneel K., Lucente D., Hadzi T., Holmans P., Jones L., Orth M., Kwak S., Macdonald ME, Gusella JF, and Lee JM American journal of human genetics, 2016/02/04, Volume 98, Issue 2, p.287-98, (2016) Read More / View Supplemental Materials
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Nuclear magnetic resonance detection and spectroscopy of single proteins using quantum logic.Lovchinsky, I., Sushkov AO, Urbach E., de Leon NP, Choi S., De Greve K., Evans R., Gertner R., Bersin E., Müller C., McGuinness L., Jelezko F., Walsworth RL, Park H., and Lukin MD Science (New York, N.Y.), 2016/02/04, (2016) Read More / View Supplemental Materials
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A Robust Example of Collider Bias in a Genetic Association Study.Day, FR, Loh PR, Scott RA, Ong KK, and Perry JR American journal of human genetics, 2016/02/04, Volume 98, Issue 2, p.392-3, (2016) Read More / View Supplemental Materials
Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.Howitt, MR, Lavoie S., Michaud M., Blum AM, Tran SV, Weinstock JV, Gallini CA, Redding K., Margolskee RF, Osborne LC, Artis D., and Garrett WS Science (New York, N.Y.), 2016/02/04, (2016) Read More / View Supplemental Materials
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Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.Davidson, SM, Papagiannakopoulos T., Olenchock BA, Heyman JE, Keibler MA, Luengo A., Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L., Chin CR, Stephanopolous G., Mott BT, Jacks T., Clish CB, and Vander Heiden MG Cell metabolism, 2016/02/03, (2016) Read More / View Supplemental Materials
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Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study.Keenan, T., Zhao W., Rasheed A., Ho WK, Malik R., Felix JF, Young R., Shah N., Samuel M., Sheikh N., Mucksavage ML, Shah O., Li J., Morley M., Laser A., Mallick NH, Zaman KS, Ishaq M., Rasheed SZ, Memon FU, et al. Journal of the American College of Cardiology, 2016/02/02, Volume 67, Issue 4, p.407-16, (2016) Read More / View Supplemental Materials
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Evolutionary analysis across mammals reveals distinct classes of long non-coding RNAs.Chen, J., Shishkin AA, Zhu X., Kadri S., Maza I., Guttman M., Hanna JH, Regev A., and Garber M. Genome biology, 2016/02/02, Volume 17, Issue 1, p.19, (2016) Read More / View Supplemental Materials
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Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis.Dubin, K., Callahan MK, Ren B., Khanin R., Viale A., Ling L., No D., Gobourne A., Littmann E., Huttenhower C., Pamer EG, and Wolchok JD Nature communications, 2016/02/02, Volume 7, p.10391, (2016) Read More / View Supplemental Materials
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Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA.Mangel, WF, McGrath WJ, Xiong K., Graziano V., and Blainey PC Nature communications, 2016/02/02, Volume 7, p.10202, (2016) Read More / View Supplemental Materials
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Unique features of a global human ectoparasite identified through sequencing of the bed bug genome.Benoit, JB, Adelman ZN, Reinhardt K., Dolan A., Poelchau M., Jennings EC, Szuter EM, Hagan RW, Gujar H., Shukla JN, Zhu F., Mohan M., Nelson DR, Rosendale AJ, Derst C., Resnik V., Wernig S., Menegazzi P., Wegener C., Peschel N., et al. Nature communications, 2016/02/02, Volume 7, p.10165, (2016) Read More / View Supplemental Materials
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Clinical trial designs incorporating predictive biomarkers.Renfro, LA, Mallick H., An MW, Sargent DJ, and Mandrekar SJ Cancer treatment reviews, 2016/02/01, Volume 43, p.74-82, (2016) Read More / View Supplemental Materials
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Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy.Muona, M., Fukata Y., Anttonen AK, Laari A., Palotie A., Pihko H., Lönnqvist T., Valanne L., Somer M., Fukata M., and Lehesjoki AE Neurology. Genetics, 2016/02/01, Volume 2, Issue 1, p.e46, (2016) Read More / View Supplemental Materials
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Effect of endocannabinoid degradation on pain: role of FAAH polymorphisms in experimental and postoperative pain in women treated for breast cancer.Cajanus, K., Holmström EJ, Wessman M., Anttila V., Kaunisto MA, and Kalso E. Pain, 2016/02/01, Volume 157, Issue 2, p.361-9, (2016) Read More / View Supplemental Materials
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Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR.Tai, DJ, Ragavendran A., Manavalan P., Stortchevoi A., Seabra CM, Erdin S., Collins RL, Blumenthal I., Chen X., Shen Y., Sahin M., Zhang C., Lee C., Gusella JF, and Talkowski ME Nature neuroscience, 2016/02/01, (2016) Read More / View Supplemental Materials
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Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.Kilpeläinen, TO, Carli JF, Skowronski AA, Sun Q., Kriebel J., Feitosa MF, Hedman Å. K., Drong AW, Hayes JE, Zhao J., Pers TH, Schick U., Grarup N., Kutalik Z., Trompet S., Mangino M., Kristiansson K., Beekman M., Lyytikäinen LP, Eriksson J., et al. Nature communications, 2016/02/01, Volume 7, p.10494, (2016) Read More / View Supplemental Materials
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The genomic landscape of cutaneous melanoma.Zhang, T., Dutton-Regester K., Brown KM, and Hayward NK Pigment cell & melanoma research, 2016/02/01, (2016) Read More / View Supplemental Materials
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Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy.Gannon, HS, Kaplan N., Tsherniak A., Vazquez F., Weir BA, Hahn WC, and Meyerson M. Molecular cancer research : MCR, 2016/02/01, Volume 14, Issue 2, p.207-15, (2016) Read More / View Supplemental Materials
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Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.de Waal, L., Lewis TA, Rees MG, Tsherniak A., Wu X., Choi PS, Hartigan C., Faloon PW, Hickey MJ, Tolliday N., Carr SA, Clemons PA, Munoz B., Wagner BK, Shamji AF, Koehler AN, Schenone M., Burgin AB, Schreiber SL, Greulich H., et al. Nature chemical biology, 2016/02/01, Volume 12, Issue 2, p.102-8, (2016) Read More / View Supplemental Materials
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Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression.Kløverpris, HN, Kazer SW, Mjösberg J., Mabuka JM, Wellmann A., Ndhlovu Z., Yadon MC, Nhamoyebonde S., Muenchhoff M., Simoni Y., Andersson F., Kuhn W., Garrett N., Burgers WA, Kamya P., Pretorius K., Dong K., Moodley A., Newell EW, Kasprowicz V., et al. Immunity, 2016/02/01, (2016) Read More / View Supplemental Materials
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Mechanism of Metformin: A Tale of Two Sites.Song, R. Diabetes care, 2016/02/01, Volume 39, Issue 2, p.187-9, (2016) Read More / View Supplemental Materials
Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity.Caron, A., Labbé SM, Lanfray D., Blanchard PG, Villot R., Roy C., Sabatini DM, Richard D., and Laplante M. Molecular metabolism, 2016/02/01, Volume 5, Issue 2, p.102-12, (2016) Read More / View Supplemental Materials
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Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3.Lu, C., Chen Q., Zhou T., Bozic D., Fu Z., Pan JQ, and Feng G. Molecular psychiatry, 2016/02/01, Volume 21, Issue 2, p.159-68, (2016) Read More / View Supplemental Materials
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MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.Bandopadhayay, P., Ramkissoon LA, Jain P., Bergthold G., Wala J., Zeid R., Schumacher SE, Urbanski L., O'Rourke R., Gibson WJ, Pelton K., Ramkissoon SH, Han HJ, Zhu Y., Choudhari N., Silva A., Boucher K., Henn RE, Kang YJ, Knoff D., et al. Nature genetics, 2016/02/01, (2016) Read More / View Supplemental Materials
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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.Lu, Y., Day FR, Gustafsson S., Buchkovich ML, Na J., Bataille V., Cousminer DL, Dastani Z., Drong AW, Esko T., Evans DM, Falchi M., Feitosa MF, Ferreira T., Hedman Å. K., Haring R., Hysi PG, Iles MM, Justice AE, Kanoni S., et al. Nature communications, 2016/02/01, Volume 7, p.10495, (2016) Read More / View Supplemental Materials
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An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.Drier, Y., Cotton MJ, Williamson KE, Gillespie SM, Ryan RJ, Kluk MJ, Carey CD, Rodig SJ, Sholl LM, Afrogheh AH, Faquin WC, Queimado L., Qi J., Wick MJ, El-Naggar AK, Bradner JE, Moskaluk CA, Aster J. C., Knoechel B., and Bernstein BE Nature genetics, 2016/02/01, (2016) Read More / View Supplemental Materials
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Research Letter: PTSD has shared polygenic contributions with bipolar disorder and schizophrenia in women.Sumner, JA, Duncan L., Ratanatharathorn A., Roberts AL, and Koenen KC Psychological medicine, 2016/02/01, Volume 46, Issue 3, p.669-71, (2016) Read More / View Supplemental Materials
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition.Hata, AN, Niederst MJ, Archibald HL, Gomez-Caraballo M., Siddiqui FM, Mulvey HE, Maruvka YE, Ji F., Bhang HC, Krishnamurthy Radhakrishna V., Siravegna G., Hu H., Raoof S., Lockerman E., Kalsy A., Lee D., Keating CL, Ruddy DA, Damon LJ, Crystal AS, et al. Nature medicine, 2016/02/01, (2016) Read More / View Supplemental Materials
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The era of synthetic biology and genome engineering: Where no man has gone before.Lu, TK, Chandrasegaran S., and Hodak H. Journal of molecular biology, 2016/01/28, (2016) Read More / View Supplemental Materials
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.Imamura, M., Takahashi A., Yamauchi T., Hara K., Yasuda K., Grarup N., Zhao W., Wang X., Huerta-Chagoya A., Hu C., Moon S., Long J., Kwak SH, Rasheed A., Saxena R., Ma RC, Okada Y., Iwata M., Hosoe J., Shojima N., et al. Nature communications, 2016/01/28, Volume 7, p.10531, (2016) Read More / View Supplemental Materials
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Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.Ceccarelli, M., Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O., Newton Y., Radenbaugh A., Pagnotta SM, Anjum S., Wang J., Manyam G., Zoppoli P., Ling S., Rao AA, Grifford M., Cherniack AD, Zhang H., Poisson L., et al. Cell, 2016/01/28, Volume 164, Issue 3, p.550-63, (2016) Read More / View Supplemental Materials
Abstract
A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans.Clapham, KR, Chu AY, Wessel J., Natarajan P., Flannick J., Rivas MA, Sartori S., Mehran R., Baber U., Fuster V., Scott RA, Rader DJ, Boehnke M., McCarthy MI, Altshuler DM, Kathiresan S., and Peloso GM BMC endocrine disorders, 2016/01/28, Volume 16, Issue 1, p.7, (2016) Read More / View Supplemental Materials
Abstract
Parsing the Interferon Transcriptional Network and Its Disease Associations.Mostafavi, S., Yoshida H., Moodley D., LeBoité H., Rothamel K., Raj T., Ye CJ, Chevrier N., Zhang SY, Feng T., Lee M., Casanova JL, Clark JD, Hegen M., Telliez JB, Hacohen N., De Jager PL, Regev A., Mathis D., Benoist C., et al. Cell, 2016/01/28, Volume 164, Issue 3, p.564-78, (2016) Read More / View Supplemental Materials
Abstract
Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma.Diamandis, P., Ferrer-Luna R., Huang RY, Folkerth RD, Ligon AH, Wen PY, Beroukhim R., Ligon KL, and Ramkissoon SH Diagnostic pathology, 2016/01/27, Volume 11, Issue 1, p.13, (2016) Read More / View Supplemental Materials
Abstract
CP-CHARM: segmentation-free image classification made accessible.Uhlmann, V., Singh S., and Carpenter AE BMC bioinformatics, 2016/01/27, Volume 17, Issue 1, p.51, (2016) Read More / View Supplemental Materials
Abstract
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