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2014
Response and acquired resistance to everolimus in anaplastic thyroid cancer.Wagle, N., Grabiner BC, Van Allen EM, Amin-Mansour A., Taylor-Weiner A., Rosenberg M., Gray N., Barletta JA, Guo Y., Swanson SJ, Ruan DT, Hanna GJ, Haddad RI, Getz G., Kwiatkowski DJ, Carter SL, Sabatini DM, Jänne PA, Garraway LA, and Lorch JH The New England journal of medicine, 2014/10/09, Volume 371, Issue 15, p.1426-33, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide Enrichment Analysis between Endometriosis and Obesity-related Traits Reveals Novel Susceptibility Loci.Rahmioglu, N., Macgregor S., Drong AW, Hedman AK, Harris HR, Randall JC, Prokopenko I., The International EndoGene Consortium(IEC), The GIANT Consortium, Nyholt DR, Morris AP, Montgomery GW, Missmer SA, Lindgren CM, Zondervan KT, and The International EndoGene Consortium IEC Human molecular genetics, 2014/10/08, (2014) Read More / View Supplemental Materials
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An exact arithmetic toolbox for a consistent and reproducible structural analysis of metabolic network models.Chindelevitch, L., Trigg J., Regev A., and Berger B. Nature communications, 2014/10/07, Volume 5, p.4893, (2014) Read More / View Supplemental Materials
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Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.The Coffee and Caffeine Genetics, Consortium, Cornelis MC, Byrne EM, Esko T., Nalls MA, Ganna A., Paynter N., Monda KL, Amin N., Fischer K., Renstrom F., Ngwa JS, Huikari V., Cavadino A., Nolte IM, Teumer A., Yu K., Marques-Vidal P., Rawal R., Manichaikul A., et al. Molecular psychiatry, 2014/10/07, (2014) Read More / View Supplemental Materials
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Identification of Orai1 Channel Inhibitors by Using Minimal Functional Domains to Screen Small Molecule Microarrays.Sadaghiani, AM, Lee SM, Odegaard JI, Leveson-Gower DB, McPherson OM, Novick P., Kim MR, Koehler AN, Negrin R., Dolmetsch RE, and Park CY Chemistry & biology, 2014/10/07, (2014) Read More / View Supplemental Materials
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Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium.Taylor, AE, Fluharty ME, Bjørngaard JH, Gabrielsen ME, Skorpen F., Marioni RE, Campbell A., Engmann J., Mirza SS, Loukola A., Laatikainen T., Partonen T., Kaakinen M., Ducci F., Cavadino A., Husemoen LL, Ahluwalia TS, Jacobsen RK, Skaaby T., Ebstrup JF, et al. BMJ open, 2014/10/07, Volume 4, Issue 10, p.e006141, (2014) Read More / View Supplemental Materials
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Defining the role of common variation in the genomic and biological architecture of adult human height.Wood, AR, Esko T., Yang J., Vedantam S., Pers TH, Gustafsson S., Chu AY, Estrada K., Luan J., Kutalik Z., Amin N., Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y., Fall T., Fehrmann R., Ferreira T., Jackson AU, Karjalainen J., et al. Nature genetics, 2014/10/05, (2014) Read More / View Supplemental Materials
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CompMap: a reference-based compression program to speed up read mapping to related reference sequences.Zhu, Z., Li L., Zhang Y., Yang Y., and Yang X. Bioinformatics (Oxford, England), 2014/10/04, (2014) Read More / View Supplemental Materials
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Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice combine to promote disease progression in myeloproliferative neoplasms.Chen, E., Schneider RK, Breyfogle LJ, Rosen EA, Poveromo L., Elf S., Ko A., Brumme K., LeVine R., Ebert BL, and Mullally A. Blood, 2014/10/03, (2014) Read More / View Supplemental Materials
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A novel common variant in DCST2 is associated with length in early life and height in adulthood.van der Valk, RJ, Kreiner-Møller E., Kooijman MN, Guxens M., Stergiakouli E., Sääf A., Bradfield JP, Geller F., Hayes MG, Cousminer DL, Körner A., Thiering E., Curtin JA, Myhre R., Huikari V., Joro R., Kerkhof M., Warrington NM, Pitkänen N., Ntalla I., et al. Human molecular genetics, 2014/10/03, (2014) Read More / View Supplemental Materials
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Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.Theurillat, JP, Udeshi ND, Errington WJ, Svinkina T., Baca SC, Pop M., Wild PJ, Blattner M., Groner AC, Rubin MA, Moch H., Privé GG, Carr SA, and Garraway LA Science (New York, N.Y.), 2014/10/03, Volume 346, Issue 6205, p.85-9, (2014) Read More / View Supplemental Materials
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Ascertainment bias causes false signal of anticipation in genetic prion disease.Minikel, EV, Zerr I., Collins SJ, Ponto C., Boyd A., Klug G., Karch A., Kenny J., Collinge J., Takada LT, Forner S., Fong JC, Mead S., and Geschwind MD American journal of human genetics, 2014/10/02, Volume 95, Issue 4, p.371-82, (2014) Read More / View Supplemental Materials
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Cryptic and complex chromosomal aberrations in early-onset neuropsychiatric disorders.Brand, H., Pillalamarri V., Collins RL, Eggert S., O'Dushlaine C., Braaten EB, Stone MR, Chambert K., Doty ND, Hanscom C., Rosenfeld JA, Ditmars H., Blais J., Mills R., Lee C., Gusella JF, McCarroll S., Smoller JW, Talkowski ME, and Doyle AE American journal of human genetics, 2014/10/02, Volume 95, Issue 4, p.454-61, (2014) Read More / View Supplemental Materials
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Hemani et al. reply.Hemani, G., Shakhbazov K., Westra HJ, Esko T., Henders AK, McRae AF, Yang J., Gibson G., Martin NG, Metspalu A., Franke L., Montgomery GW, Visscher PM, and Powell JE Nature, 2014/10/02, Volume 514, Issue 7520, p.E5-6, (2014) Read More / View Supplemental Materials
Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cells.McCole, RB, Fonseka CY, Koren A., and Wu CT PLoS genetics, 2014/10/01, Volume 10, Issue 10, p.e1004646, (2014) Read More / View Supplemental Materials
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Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children.Groen-Blokhuis, MM, Middeldorp CM, Kan KJ, Abdellaoui A., van Beijsterveldt CE, Ehli EA, Davies GE, Scheet PA, Xiao X., Hudziak JJ, Hottenga JJ, Psychiatric Genomics Consortium ADHD Working Group, Neale BM, and Boomsma DI Journal of the American Academy of Child and Adolescent Psychiatry, 2014/10/01, Volume 53, Issue 10, p.1123-1129.e6, (2014) Read More / View Supplemental Materials
Abstract
Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer.Buffen, K., Oosting M., Quintin J., Ng A., Kleinnijenhuis J., Kumar V., van de Vosse E., Wijmenga C., van Crevel R., Oosterwijk E., Grotenhuis AJ, Vermeulen SH, Kiemeney LA, van de Veerdonk FL, Chamilos G., Xavier RJ, van der Meer JW, Netea MG, and Joosten LA PLoS pathogens, 2014/10/01, Volume 10, Issue 10, p.e1004485, (2014) Read More / View Supplemental Materials
Abstract
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.Mayers, JR, Wu C., Clish CB, Kraft P., Torrence ME, Fiske BP, Yuan C., Bao Y., Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T., Yang A., Dayton TL, Ogino S., Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J., et al. Nature medicine, 2014/10/01, Volume 20, Issue 10, p.1193-8, (2014) Read More / View Supplemental Materials
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Functional Analysis of SPECC1L in Craniofacial Development and Oblique Facial Cleft Pathogenesis.Gfrerer, L., Shubinets V., Hoyos T., Kong Y., Nguyen C., Pietschmann P., Morton CC, Maas RL, and Liao EC Plastic and reconstructive surgery, 2014/10/01, Volume 134, Issue 4, p.748-59, (2014) Read More / View Supplemental Materials
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Genetic Studies of Major Depressive Disorder: Why Are There No Genome-wide Association Study Findings and What Can We Do About It?Levinson, DF, Mostafavi S., Milaneschi Y., Rivera M., Ripke S., Wray NR, and Sullivan PF Biological psychiatry, 2014/10/01, Volume 76, Issue 7, p.510-2, (2014) Read More / View Supplemental Materials
Pulmonary macrophage transplantation therapy.Suzuki, T., Arumugam P., Sakagami T., Lachmann N., Chalk C., Sallese A., Abe S., Trapnell C., Carey B., Moritz T., Malik P., Lutzko C., Wood RE, and Trapnell BC Nature, 2014/10/01, (2014) Read More / View Supplemental Materials
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Therapeutic Strategies to Inhibit MYC.McKeown, MR, and Bradner JE Cold Spring Harbor perspectives in medicine, 2014/10/01, Volume 4, Issue 10, (2014) Read More / View Supplemental Materials
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Does poor health predict moving, move quality, and desire to move?: A study examining neighborhood selection in US adolescents and adults.Dunn, EC, Winning A., Zaika N., and Subramanian SV Health & place, 2014/09/30, Volume 30C, p.154-164, (2014) Read More / View Supplemental Materials
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Expanding the Phenotype Associated With the NEFL Mutation: Neuromuscular Disease in a Family With Overlapping Myopathic and Neurogenic Findings.Agrawal, PB, Joshi M., Marinakis NS, Schmitz-Abe K., Ciarlini PD, Sargent JC, Markianos K., De Girolami U., Chad DA, and Beggs AH JAMA neurology, 2014/09/29, (2014) Read More / View Supplemental Materials
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A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.Lu, H., Clauser KR, Tam WL, Fröse J., Ye X., Eaton EN, Reinhardt F., Donnenberg VS, Bhargava R., Carr SA, and Weinberg R. A. Nature cell biology, 2014/09/28, (2014) Read More / View Supplemental Materials
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Comparative RNA-Seq based dissection of the regulatory networks and environmental stimuli underlying Vibrio parahaemolyticus gene expression during infection.Livny, J., Zhou X., Mandlik A., Hubbard T., Davis BM, and Waldor MK Nucleic acids research, 2014/09/27, (2014) Read More / View Supplemental Materials
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Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.Saeed, S., Quintin J., Kerstens HH, Rao NA, Aghajanirefah A., Matarese F., Cheng SC, Ratter J., Berentsen K., van der Ent MA, Sharifi N., Janssen-Megens EM, Ter Huurne M., Mandoli A., van Schaik T., Ng A., Burden F., Downes K., Frontini M., Kumar V., et al. Science (New York, N.Y.), 2014/09/26, Volume 345, Issue 6204, p.1251086, (2014) Read More / View Supplemental Materials
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mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.Cheng, SC, Quintin J., Cramer RA, Shepardson KM, Saeed S., Kumar V., Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A., Manjeri GR, Li Y., Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C., O'Neill LA, Willems P., van de Veerdonk FL, et al. Science (New York, N.Y.), 2014/09/26, Volume 345, Issue 6204, p.1250684, (2014) Read More / View Supplemental Materials
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Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5.Abedalthagafi, MS, Merrill PH, Bi WL, Jones RT, Listewnik ML, Ramkissoon SH, Thorner AR, Dunn IF, Beroukhim R., Alexander BM, Brastianos PK, Francis JM, Folkerth RD, Ligon KL, Van Hummelen P., Ligon AH, and Santagata S. Oncotarget, 2014/09/25, (2014) Read More / View Supplemental Materials
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Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7.Foroud, T., Lai D., Koller D., Van't Hof F., Kurki MI, Anderson CS, Brown RD Jr, Connolly ES, Eriksson JG, Flaherty M., Fornage M., von Und Zu Fraunberg M., Gaál EI, Laakso A., Hernesniemi J., Huston J., Jääskeläinen JE, Kiemeney LA, Kivisaari R., Kleindorfer D., et al. Stroke; a journal of cerebral circulation, 2014/09/25, (2014) Read More / View Supplemental Materials
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RNA-RNA Interactions Enable Specific Targeting of Noncoding RNAs to Nascent Pre-mRNAs and Chromatin Sites.Engreitz, JM, Sirokman K., McDonel P., Shishkin AA, Surka C., Russell P., Grossman SR, Chow AY, Guttman M., and Lander E. S. Cell, 2014/09/25, Volume 159, Issue 1, p.188-99, (2014) Read More / View Supplemental Materials
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CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.Platt, RJ, Chen S., Zhou Y., Yim MJ, Swiech L., Kempton HR, Dahlman JE, Parnas O., Eisenhaure TM, Jovanovic M., Graham DB, Jhunjhunwala S., Heidenreich M., Xavier RJ, Langer R., Anderson DG, Hacohen N., Regev A., Feng G., Sharp PA, et al. Cell, 2014/09/24, (2014) Read More / View Supplemental Materials
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HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.Swerdlow, DI, Preiss D., Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T., Sofat R., Stender S., Johnson PC, Scott RA, Leusink M., Verweij N., Sharp SJ, Guo Y., Giambartolomei C., Chung C., Peasey A., Amuzu A., Li K., Palmen J., et al. Lancet, 2014/09/24, (2014) Read More / View Supplemental Materials
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The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1.Chantranupong, L., Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L., Spooner E., Isasa M., Gygi SP, and Sabatini DM Cell reports, 2014/09/24, (2014) Read More / View Supplemental Materials
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Small molecules facilitate rapid and synchronous iPSC generation.Bar-Nur, O., Brumbaugh J., Verheul C., Apostolou E., Pruteanu-Malinici I., Walsh RM, Ramaswamy S., and Hochedlinger K. Nature methods, 2014/09/24, (2014) Read More / View Supplemental Materials
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Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts.Ek, WE, Reznichenko A., Ripke S., Niesler B., Zucchelli M., Rivera NV, Schmidt PT, Pedersen NL, Magnusson P., Talley NJ, Holliday EG, Houghton L., Gazouli M., Karamanolis G., Rappold G., Burwinkel B., Surowy H., Rafter J., Assadi G., Li L., et al. Gut, 2014/09/23, (2014) Read More / View Supplemental Materials
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Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.Draberova, L., Bugajev V., Potuckova L., Halova I., Bambouskova M., Polakovicova I., Xavier RJ, Seed B., and Draber P. Molecular and cellular biology, 2014/09/22, (2014) Read More / View Supplemental Materials
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Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases.Citorik, RJ, Mimee M., and Lu TK Nature biotechnology, 2014/09/21, (2014) Read More / View Supplemental Materials
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Ancient human genomes suggest three ancestral populations for present-day Europeans.Lazaridis, I., Patterson N., Mittnik A., Renaud G., Mallick S., Kirsanow K., Sudmant PH, Schraiber JG, Castellano S., Lipson M., Berger B., Economou C., Bollongino R., Fu Q., Bos KI, Nordenfelt S., Li H., de Filippo C., Prüfer K., Sawyer S., et al. Nature, 2014/09/18, Volume 513, Issue 7518, p.409-13, (2014) Read More / View Supplemental Materials
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Genome Sequence of the Microsporidian Species Nematocida sp1 Strain ERTm6 (ATCC PRA-372).Bakowski, MA, Priest M., Young S., Cuomo CA, and Troemel ER Genome announcements, 2014/09/18, Volume 2, Issue 5, (2014) Read More / View Supplemental Materials
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Proteogenomic characterization of human colon and rectal cancer.Zhang, B., Wang J., Wang X., Zhu J., Liu Q., Shi Z., Chambers MC, Zimmerman LJ, Shaddox KF, Kim S., Davies SR, Wang S., Wang P., Kinsinger CR, Rivers RC, Rodriguez H., Townsend RR, Ellis MJ, Carr SA, Tabb DL, et al. Nature, 2014/09/18, Volume 513, Issue 7518, p.382-7, (2014) Read More / View Supplemental Materials
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Genome-wide Scan of 29,141 African Americans Finds No Evidence of Directional Selection since Admixture.Bhatia, G., Tandon A., Patterson N., Aldrich MC, Ambrosone CB, Amos C., Bandera EV, Berndt SI, Bernstein L., Blot WJ, Bock CH, Caporaso N., Casey G., Deming SL, Diver WR, Gapstur SM, Gillanders EM, Harris CC, Henderson BE, Ingles SA, et al. American journal of human genetics, 2014/09/17, (2014) Read More / View Supplemental Materials
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Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS.Schneider, RK, Ademà V., Heckl D., Järås M., Mallo M., Lord AM, Chu LP, McConkey ME, Kramann R., Mullally A., Bejar R., Solé F., and Ebert BL Cancer cell, 2014/09/17, (2014) Read More / View Supplemental Materials
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Pipeline for illumination correction of images for high-throughput microscopy.Singh, S., Bray MA, Jones TR, and Carpenter AE Journal of microscopy, 2014/09/16, (2014) Read More / View Supplemental Materials
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Sporulation during growth in a gut isolate of Bacillus subtilis.Serra, CR, Earl AM, Barbosa TM, Kolter R., and Henriques AO Journal of bacteriology, 2014/09/15, (2014) Read More / View Supplemental Materials
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TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Blood, 2014/09/15, (2014) Read More / View Supplemental Materials
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Nanoparticle vesicle encoding for imaging and tracking cell populations.Rees, P., Wills JW, Brown MR, Tonkin J., Holton MD, Hondow N., Brown AP, Brydson R., Millar V., Carpenter AE, and Summers HD Nature methods, 2014/09/14, (2014) Read More / View Supplemental Materials
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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak.Gire, SK, Goba A., Andersen KG, Sealfon RS, Park DJ, Kanneh L., Jalloh S., Momoh M., Fullah M., Dudas G., Wohl S., Moses LM, Yozwiak NL, Winnicki S., Matranga CB, Malboeuf CM, Qu J., Gladden AD, Schaffner SF, Yang X., et al. Science (New York, N.Y.), 2014/09/12, Volume 345, Issue 6202, p.1369-72, (2014) Read More / View Supplemental Materials
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Intersection of population variation and autoimmunity genetics in human T cell activation.Ye, CJ, Feng T., Kwon HK, Raj T., Wilson MT, Asinovski N., McCabe C., Lee MH, Frohlich I., Paik HI, Zaitlen N., Hacohen N., Stranger B., De Jager P., Mathis D., Regev A., and Benoist C. Science (New York, N.Y.), 2014/09/12, Volume 345, Issue 6202, p.1254665, (2014) Read More / View Supplemental Materials
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RNA Function. RNA and dynamic nuclear organization.Rinn, J., and Guttman M. Science (New York, N.Y.), 2014/09/12, Volume 345, Issue 6202, p.1240-1, (2014) Read More / View Supplemental Materials
Small-molecule control of cytokine function: new opportunities for treating immune disorders.Sundberg, TB, Xavier RJ, Schreiber SL, and Shamji AF Current opinion in chemical biology, 2014/09/12, Volume 23C, p.23-30, (2014) Read More / View Supplemental Materials
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Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.Wang, YH, Israelsen WJ, Lee D., Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, and Scadden DT Cell, 2014/09/11, Volume 158, Issue 6, p.1309-23, (2014) Read More / View Supplemental Materials
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Draft genome sequences of six enterohepatic helicobacter species isolated from humans and one from rhesus macaques.Shen, Z., Sheh A., Young SK, Abouelliel A., Ward DV, Earl AM, and Fox JG Genome announcements, 2014/09/11, Volume 2, Issue 5, (2014) Read More / View Supplemental Materials
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Effect of phosphodiesterase inhibition on insulin resistance in obese individuals.Ho, JE, Arora P., Walford GA, Ghorbani A., Guanaga DP, Dhakal BP, Nathan DI, Buys ES, Florez JC, Newton-Cheh C., Lewis GD, and Wang TJ Journal of the American Heart Association, 2014/09/11, Volume 3, Issue 5, (2014) Read More / View Supplemental Materials
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Gibbon genome and the fast karyotype evolution of small apes.Carbone, L., Harris RA, Gnerre S., Veeramah KR, Lorente-Galdos B., Huddleston J., Meyer TJ, Herrero J., Roos C., Aken B., Anaclerio F., Archidiacono N., Baker C., Barrell D., Batzer MA, Beal K., Blancher A., Bohrson CL, Brameier M., Campbell MS, et al. Nature, 2014/09/11, Volume 513, Issue 7517, p.195-201, (2014) Read More / View Supplemental Materials
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Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA.Schwartz, S., Bernstein DA, Mumbach MR, Jovanovic M., Herbst RH, León-Ricardo BX, Engreitz JM, Guttman M., Satija R., Lander E. S., Fink G., and Regev A. Cell, 2014/09/10, (2014) Read More / View Supplemental Materials
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The unconscionable gap between what we know and what we do.Hyman, SE Science translational medicine, 2014/09/10, Volume 6, Issue 253, p.253cm9, (2014) Read More / View Supplemental Materials
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Aspirin Should Be Discontinued After Lobar Intracerebral Hemorrhage.Falcone, GJ, and Rosand J. Stroke; a journal of cerebral circulation, 2014/09/09, (2014) Read More / View Supplemental Materials
Evaluation of compounds in primary human islet cell culture.Walpita, D., and Wagner BK Current protocols in chemical biology, 2014/09/09, Volume 6, Issue 3, p.157-68, (2014) Read More / View Supplemental Materials
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Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells.Ben-David, U., Arad G., Weissbein U., Mandefro B., Maimon A., Golan-Lev T., Narwani K., Clark AT, Andrews PW, Benvenisty N., and Carlos Biancotti J. Nature communications, 2014/09/08, Volume 5, p.4825, (2014) Read More / View Supplemental Materials
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Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.Rietveld, CA, Esko T., Davies G., Pers TH, Turley P., Benyamin B., Chabris CF, Emilsson V., Johnson AD, Lee JJ, de Leeuw C., Marioni RE, Medland SE, Miller MB, Rostapshova O., van der Lee SJ, Vinkhuyzen AA, Amin N., Conley D., Derringer J., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/09/08, (2014) Read More / View Supplemental Materials
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Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease: A Genome-Wide Association Study.Naj, AC, Jun G., Reitz C., Kunkle BW, Perry W., Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E., Barmada MM, et al. JAMA neurology, 2014/09/08, (2014) Read More / View Supplemental Materials
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GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.Broer, L., Buchman AS, Deelen J., Evans DS, Faul JD, Lunetta KL, Sebastiani P., Smith JA, Smith AV, Tanaka T., Yu L., Arnold AM, Aspelund T., Benjamin EJ, De Jager PL, Eirkisdottir G., Evans DA, Garcia ME, Hofman A., Kaplan RC, et al. The journals of gerontology. Series A, Biological sciences and medical sciences, 2014/09/08, (2014) Read More / View Supplemental Materials
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Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.Kumar, V., Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A., Giamarellos-Bourboulis E., Karjalainen J., Franke L., Withoff S., Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H., Bauer H., Herrmann BG, Bochud PY, Marchetti O., Perfect JR, Xavier RJ, et al. Nature communications, 2014/09/08, Volume 5, p.4675, (2014) Read More / View Supplemental Materials
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Genome-wide identification and characterization of functional neuronal activity-dependent enhancers.Malik, AN, Vierbuchen T., Hemberg M., Rubin AA, Ling E., Couch CH, Stroud H., Spiegel I., Farh KK, Harmin DA, and Greenberg ME Nature neuroscience, 2014/09/07, (2014) Read More / View Supplemental Materials
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The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera.Ahola, V., Lehtonen R., Somervuo P., Salmela L., Koskinen P., Rastas P., Välimäki N., Paulin L., Kvist J., Wahlberg N., Tanskanen J., Hornett EA, Ferguson LC, Luo S., Cao Z., de Jong MA, Duplouy A., Smolander OP, Vogel H., McCoy RC, et al. Nature communications, 2014/09/05, Volume 5, p.4737, (2014) Read More / View Supplemental Materials
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Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.Goldstein, JI, Fredrik Jarskog L., Hilliard C., Alfirevic A., Duncan L., Fourches D., Huang H., Lek M., Neale BM, Ripke S., Shianna K., Szatkiewicz JP, Tropsha A., van den Oord EJ, Cascorbi I., Dettling M., Gazit E., Goff DC, Holden AL, Kelly DL, et al. Nature communications, 2014/09/04, Volume 5, p.4757, (2014) Read More / View Supplemental Materials
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Association of exome sequences with plasma C-reactive protein levels in >9000 participants.Schick, UM, Auer PL, Bis JC, Lin H., Wei P., Pankratz N., Lange LA, Brody J., Stitziel NO, Kim DS, Carlson CS, Fornage M., Haessler J., Hsu L., Jackson RD, Kooperberg C., Leal SM, Psaty BM, Boerwinkle E., Tracy R., et al. Human molecular genetics, 2014/09/03, (2014) Read More / View Supplemental Materials
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The Genomic Landscape of Pediatric Ewing Sarcoma.Crompton, BD, Stewart C., Taylor-Weiner A., Alexe G., Kurek KC, Calicchio ML, Kiezun A., Carter SL, Shukla SA, Mehta SS, Thorner AR, de Torres C., Lavarino C., Sunol M., McKenna A., Sivachenko A., Cibulskis K., Lawrence MS, Stojanov P., Rosenberg M., et al. Cancer discovery, 2014/09/03, (2014) Read More / View Supplemental Materials
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The genomic substrate for adaptive radiation in African cichlid fish.Brawand, D., Wagner CE, Li YI, Malinsky M., Keller I., Fan S., Simakov O., Ng AY, Lim ZW, Bezault E., Turner-Maier J., Johnson J., Alcazar R., Noh HJ, Russell P., Aken B., Alföldi J., Amemiya C., Azzouzi N., Baroiller JF, et al. Nature, 2014/09/03, (2014) Read More / View Supplemental Materials
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Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.Doench, JG, Hartenian E., Graham DB, Tothova Z., Hegde M., Smith I., Sullender M., Ebert BL, Xavier RJ, and Root DE Nature biotechnology, 2014/09/03, (2014) Read More / View Supplemental Materials
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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.De Jager, PL, Srivastava G., Lunnon K., Burgess J., Schalkwyk LC, Yu L., Eaton ML, Keenan BT, Ernst J., McCabe C., Tang A., Raj T., Replogle J., Brodeur W., Gabriel S., Chai HS, Younkin C., Younkin SG, Zou F., Szyf M., et al. Nature neuroscience, 2014/09/01, Volume 17, Issue 9, p.1156-1163, (2014) Read More / View Supplemental Materials
Abstract
Computational pathology: an emerging definition.Louis, DN, Gerber GK, Baron JM, Bry L., Dighe AS, Getz G., Higgins JM, Kuo FC, Lane WJ, Michaelson JS, Le LP, Mermel CH, Gilbertson JR, and Golden JA Archives of pathology & laboratory medicine, 2014/09/01, Volume 138, Issue 9, p.1133-8, (2014) Read More / View Supplemental Materials
De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling.Del Vecchio, CA, Feng Y., Sokol ES, Tillman EJ, Sanduja S., Reinhardt F., and Gupta PB PLoS biology, 2014/09/01, Volume 12, Issue 9, p.e1001945, (2014) Read More / View Supplemental Materials
Abstract
Identification of small compound biomarkers of pituitary adenoma: a bilateral inferior petrosal sinus sampling study.Oklu, R., Deipolyi AR, Wicky S., Ergul E., Deik AA, Chen JW, Hirsch JA, Wojtkiewicz GR, and Clish CB Journal of neurointerventional surgery, 2014/09/01, Volume 6, Issue 7, p.541-6, (2014) Read More / View Supplemental Materials
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Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease.Lunnon, K., Smith R., Hannon E., De Jager PL, Srivastava G., Volta M., Troakes C., Al-Sarraj S., Burrage J., Macdonald R., Condliffe D., Harries LW, Katsel P., Haroutunian V., Kaminsky Z., Joachim C., Powell J., Lovestone S., Bennett DA, Schalkwyk LC, et al. Nature neuroscience, 2014/09/01, Volume 17, Issue 9, p.1164-1170, (2014) Read More / View Supplemental Materials
Abstract
Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.Hill, SJ, Rolland T., Adelmant G., Xia X., Owen MS, Dricot A., Zack TI, Sahni N., Jacob Y., Hao T., McKinney KM, Clark AP, Reyon D., Tsai SQ, Joung JK, Beroukhim R., Marto JA, Vidal M., Gaudet S., Hill DE, et al. Genes & development, 2014/09/01, Volume 28, Issue 17, p.1957-75, (2014) Read More / View Supplemental Materials
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Toward a new history and geography of human genes informed by ancient DNA.Pickrell, JK, and Reich D. Trends in genetics : TIG, 2014/09/01, Volume 30, Issue 9, p.377-389, (2014) Read More / View Supplemental Materials
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Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication.Carneiro, M., Rubin CJ, Di Palma F., Albert FW, Alföldi J., Barrio AM, Pielberg G., Rafati N., Sayyab S., Turner-Maier J., Younis S., Afonso S., Aken B., Alves JM, Barrell D., Bolet G., Boucher S., Burbano HA, Campos R., Chang JL, et al. Science (New York, N.Y.), 2014/08/29, Volume 345, Issue 6200, p.1074-9, (2014) Read More / View Supplemental Materials
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Comparative analysis of metazoan chromatin organization.Ho, JW, Jung YL, Liu T., Alver BH, Lee S., Ikegami K., Sohn KA, Minoda A., Tolstorukov MY, Appert A., Parker SC, Gu T., Kundaje A., Riddle NC, Bishop E., Egelhofer TA, Hu SS, Alekseyenko AA, Rechtsteiner A., Asker D., et al. Nature, 2014/08/28, Volume 512, Issue 7515, p.449-52, (2014) Read More / View Supplemental Materials
Abstract
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.Shaul, YD, Freinkman E., Comb WC, Cantor JR, Tam WL, Thiru P., Kim D., Kanarek N., Pacold ME, Chen WW, Bierie B., Possemato R., Reinhardt F., Weinberg R. A., Yaffe MB, and Sabatini DM Cell, 2014/08/28, Volume 158, Issue 5, p.1094-109, (2014) Read More / View Supplemental Materials
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Guided visual exploration of genomic stratifications in cancer.Streit, M., Lex A., Gratzl S., Partl C., Schmalstieg D., Pfister H., Park PJ, and Gehlenborg N. Nature methods, 2014/08/28, Volume 11, Issue 9, p.884-5, (2014) Read More / View Supplemental Materials
Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease.Tada, H., Won HH, Melander O., Yang J., Peloso GM, and Kathiresan S. Circulation. Cardiovascular genetics, 2014/08/28, (2014) Read More / View Supplemental Materials
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The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations.Keane, M., Craig T., Alföldi J., Berlin AM, Johnson J., Seluanov A., Gorbunova V., Di Palma F., Lindblad-Toh K., Church GM, and de Magalhães JP Bioinformatics (Oxford, England), 2014/08/28, (2014) Read More / View Supplemental Materials
Abstract
Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality.Jerby-Arnon, L., Pfetzer N., Waldman YY, McGarry L., James D., Shanks E., Seashore-Ludlow B., Weinstock A., Geiger T., Clemons PA, Gottlieb E., and Ruppin E. Cell, 2014/08/28, Volume 158, Issue 5, p.1199-209, (2014) Read More / View Supplemental Materials
Abstract
Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness.Wang, JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, and Perlis RH Translational psychiatry, 2014/08/26, Volume 4, p.e428, (2014) Read More / View Supplemental Materials
Abstract
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.Majithia, AR, Flannick J., Shahinian P., Guo M., Bray MA, Fontanillas P., Gabriel SB, GoT2D Consortium, NHGRI JHS/FHS Allelic Spectrum Project, SIGMA T2D Consortium, T2D-GENES Consortium, Rosen ED, Altshuler D., and GoT2D Consortium Proceedings of the National Academy of Sciences of the United States of America, 2014/08/25, (2014) Read More / View Supplemental Materials
Abstract
Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation.Andresen, L., Hampton D., Taylor A., Morel L., Yang Y., Maguire J., and Dulla CG Neurobiology of disease, 2014/08/23, (2014) Read More / View Supplemental Materials
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APOE ε variants increase risk of warfarin-related intracerebral hemorrhage.Falcone, GJ, Radmanesh F., Brouwers HB, Battey TW, Devan WJ, Valant V., Raffeld MR, Chitsike LP, Ayres AM, Schwab K., Goldstein JN, Viswanathan A., Greenberg SM, Selim M., Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Flaherty ML, et al. Neurology, 2014/08/22, (2014) Read More / View Supplemental Materials
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Cosi2 : An efficient simulator of exact and approximate coalescent with selection.Shlyakhter, I., Sabeti PC, and Schaffner SF Bioinformatics (Oxford, England), 2014/08/22, (2014) Read More / View Supplemental Materials
Abstract
ProtocolNavigator: emulation based software for the design, documentation and reproduction biological experiments.Khan, IA, Fraser A., Bray MA, Smith PJ, White NS, Carpenter AE, and Errington RJ Bioinformatics (Oxford, England), 2014/08/22, (2014) Read More / View Supplemental Materials
Abstract
Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.Fox, IJ, Daley GQ, Goldman SA, Huard J., Kamp TJ, and Trucco M. Science (New York, N.Y.), 2014/08/22, Volume 345, Issue 6199, p.1247391, (2014) Read More / View Supplemental Materials
Abstract
Multivariate inference of pathway activity in host immunity and response to therapeutics.Goel, G., Conway KL, Jaeger M., Netea MG, and Xavier RJ Nucleic acids research, 2014/08/21, (2014) Read More / View Supplemental Materials
Abstract
PyBamView: a browser based application for viewing short read alignments.Gymrek, M. Bioinformatics (Oxford, England), 2014/08/21, (2014) Read More / View Supplemental Materials
Abstract
Somatic Mutations in Cerebral Cortical Malformations.Jamuar, SS, Lam AT, Kircher M., D'Gama AM, Wang J., Barry BJ, Zhang X., Hill RS, Partlow JN, Rozzo A., Servattalab S., Mehta BK, Topcu M., Amrom D., Andermann E., Dan B., Parrini E., Guerrini R., Scheffer IE, Berkovic SF, et al. The New England journal of medicine, 2014/08/21, Volume 371, Issue 8, p.733-743, (2014) Read More / View Supplemental Materials
Abstract
Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain.Cai, X., Evrony GD, Lehmann HS, Elhosary PC, Mehta BK, Poduri A., and Walsh CA Cell reports, 2014/08/20, (2014) Read More / View Supplemental Materials
Abstract
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma.Davis, CF, Ricketts CJ, Wang M., Yang L., Cherniack AD, Shen H., Buhay C., Kang H., Kim SC, Fahey CC, Hacker KE, Bhanot G., Gordenin DA, Chu A., Gunaratne PH, Biehl M., Seth S., Kaipparettu BA, Bristow CA, Donehower LA, et al. Cancer cell, 2014/08/20, (2014) Read More / View Supplemental Materials
Abstract
DNA replication timing: Coordinating genome stability with genome regulation on the X chromosome and beyond.Koren, A. BioEssays : news and reviews in molecular, cellular and developmental biology, 2014/08/19, (2014) Read More / View Supplemental Materials
Abstract
Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma.Moore, NF, Azarova AM, Bhatnagar N., Ross KN, Drake LE, Frumm S., Liu QS, Christie AL, Sanda T., Chesler L., Kung AL, Gray NS, Stegmaier K., and George RE Oncotarget, 2014/08/19, (2014) Read More / View Supplemental Materials
Abstract
Reconstructing Austronesian population history in Island Southeast Asia.Lipson, M., Loh PR, Patterson N., Moorjani P., Ko YC, Stoneking M., Berger B., and Reich D. Nature communications, 2014/08/19, Volume 5, p.4689, (2014) Read More / View Supplemental Materials
Abstract
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