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2015
The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington's Disease.Correia, K., Harold D., Kim KH, Holmans P., Jones L., Orth M., Myers RH, Kwak S., Wheeler VC, Macdonald ME, Gusella JF, and Lee JM Journal of Huntington's disease, 2015/09/29, Volume 4, Issue 3, p.279-84, (2015) Read More / View Supplemental Materials
Abstract
MetaPhlAn2 for enhanced metagenomic taxonomic profiling.Truong, DT, Franzosa EA, Tickle TL, Scholz M., Weingart G., Pasolli E., Tett A., Huttenhower C., and Segata N. Nature methods, 2015/09/29, Volume 12, Issue 10, p.902-3, (2015) Read More / View Supplemental Materials
Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase.Chen, CL, Hu Y., Udeshi ND, Lau TY, Wirtz-Peitz F., He L., Ting AY, Carr SA, and Perrimon N. Proceedings of the National Academy of Sciences of the United States of America, 2015/09/29, Volume 112, Issue 39, p.12093-8, (2015) Read More / View Supplemental Materials
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RDTs as a source of DNA to study Plasmodium falciparum drug resistance in isolates from Senegal and the Comoros Islands.Papa Mze, N., Ndiaye YD, Diedhiou CK, Rahamatou S., Dieye B., Daniels RF, Hamilton EJ, Diallo M., Bei AK, Wirth DF, Mboup S., Volkman SK, Ahouidi AD, and Ndiaye D. Malaria journal, 2015/09/29, Volume 14, Issue 1, p.373, (2015) Read More / View Supplemental Materials
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Association of APOE with tau-tangle pathology with and without β-amyloid.Farfel, JM, Yu L., De Jager PL, Schneider JA, and Bennett DA Neurobiology of aging, 2015/09/28, (2015) Read More / View Supplemental Materials
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An atlas of genetic correlations across human diseases and traits.Bulik-Sullivan, B., Finucane HK, Anttila V., Gusev A., Day FR, Loh PR, ReproGen Consortium, Psychiatric Genomics Consortium, Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3, Duncan L., Perry JR, Patterson N., Robinson EB, Daly M. J., Price AL, and Neale BM Nature genetics, 2015/09/28, (2015) Read More / View Supplemental Materials
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CD33 modulates TREM2: convergence of Alzheimer loci.Chan, G., White CC, Winn PA, Cimpean M., Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, Bradshaw EM, and De Jager PL Nature neuroscience, 2015/09/28, (2015) Read More / View Supplemental Materials
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Extending the 'cross-disorder' relevance of executive functions to dimensional neuropsychiatric traits in youth.McGrath, LM, Braaten EB, Doty ND, Willoughby BL, Wilson HK, O'Donnell EH, Colvin MK, Ditmars HL, Blais JE, Hill EN, Metzger A., Perlis RH, Willcutt EG, Smoller JW, Waldman ID, Faraone SV, Seidman LJ, and Doyle AE Journal of child psychology and psychiatry, and allied disciplines, 2015/09/28, (2015) Read More / View Supplemental Materials
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Partitioning heritability by functional annotation using genome-wide association summary statistics.Finucane, HK, Bulik-Sullivan B., Gusev A., Trynka G., Reshef Y., Loh PR, Anttila V., Xu H., Zang C., Farh K., Ripke S., Day FR, ReproGen Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, RACI Consortium, Purcell S., Stahl E., Lindstrom S., Perry JR, Okada Y., et al. Nature genetics, 2015/09/28, (2015) Read More / View Supplemental Materials
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Reply to Lee: Downward bias in heritability estimation is not due to simplified linkage equilibrium SNP simulation.Golan, D., Rosset S., and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2015/09/28, (2015) Read More / View Supplemental Materials
A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation.Chetty, S., Engquist EN, Mehanna E., Lui KO, Tsankov AM, and Melton DA The Journal of cell biology, 2015/09/28, Volume 210, Issue 7, p.1257-68, (2015) Read More / View Supplemental Materials
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Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.Brastianos, PK, Carter SL, Santagata S., Cahill DP, Taylor-Weiner A., Jones RT, Van Allen EM, Lawrence MS, Horowitz PM, Cibulskis K., Ligon KL, Tabernero J., Seoane J., Martinez-Saez E., Curry WT, Dunn IF, Paek SH, Park SH, McKenna A., Chevalier A., et al. Cancer discovery, 2015/09/26, (2015) Read More / View Supplemental Materials
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How Y-Family DNA polymerase IV is more accurate than Dpo4 at dCTP insertion opposite an N2-dG adduct of benzo a pyrene.Sholder, G., Creech A., and Loechler EL DNA repair, 2015/09/26, Volume 35, p.144-153, (2015) Read More / View Supplemental Materials
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Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer.Terai, H., Tan L., Beauchamp EM, Hatcher JM, Liu Q., Meyerson M., Gray NS, and Hammerman PS ACS chemical biology, 2015/09/25, (2015) Read More / View Supplemental Materials
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High-throughput approaches to unravel hepatitis C virus-host interactions.Colpitts, CC, El-Saghire H., Pochet N., Schuster C., and Baumert TF Virus research, 2015/09/24, (2015) Read More / View Supplemental Materials
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CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants.Spisák, S., Lawrenson K., Fu Y., Csabai I., Cottman RT, Seo JH, Haiman C., Han Y., Lenci R., Li Q., Tisza V., Szállási Z., Herbert ZT, Chabot M., Pomerantz M., Solymosi N., GAME-ON/ELLIPSE Consortium, Gayther SA, Joung JK, and Freedman ML Nature medicine, 2015/09/23, (2015) Read More / View Supplemental Materials
Abstract
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System.Zetsche, B., Gootenberg JS, Abudayyeh OO, Slaymaker IM, Makarova KS, Essletzbichler P., Volz SE, Joung J., van der Oost J., Regev A., Koonin EV, and Zhang F. Cell, 2015/09/23, (2015) Read More / View Supplemental Materials
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Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.Sanders, SJ, He X., Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, Murtha MT, Bal VH, Bishop SL, Dong S., Goldberg AP, Jinlu C., Keaney JF 3rd, Klei L., Mandell JD, Moreno-De-Luca D., Poultney CS, Robinson EB, Smith L., Solli-Nowlan T., et al. Neuron, 2015/09/23, Volume 87, Issue 6, p.1215-33, (2015) Read More / View Supplemental Materials
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Common alleles contribute to schizophrenia in CNV carriers.Tansey, KE, Rees E., Linden DE, Ripke S., Chambert KD, Moran JL, McCarroll SA, Holmans P., Kirov G., Walters J., Owen MJ, and O'Donovan MC Molecular psychiatry, 2015/09/22, (2015) Read More / View Supplemental Materials
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Genome-wide autozygosity is associated with lower general cognitive ability.Howrigan, DP, Simonson MA, Davies G., Harris SE, Tenesa A., Starr JM, Liewald DC, Deary IJ, McRae A., Wright MJ, Montgomery GW, Hansell N., Martin NG, Payton A., Horan M., Ollier WE, Abdellaoui A., Boomsma DI, DeRosse P., Knowles EE, et al. Molecular psychiatry, 2015/09/22, (2015) Read More / View Supplemental Materials
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Massively parallel sequencing of single cells by epicPCR links functional genes with phylogenetic markers.Spencer, SJ, Tamminen MV, Preheim SP, Guo MT, Briggs AW, Brito IL, Weitz DA, Pitkänen LK, Vigneault F., Virta MP, and Alm EJ The ISME journal, 2015/09/22, (2015) Read More / View Supplemental Materials
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DNA sense-and-respond protein modules for mammalian cells.Slomovic, S., and Collins JJ Nature methods, 2015/09/21, (2015) Read More / View Supplemental Materials
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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.Kato, N., Loh M., Takeuchi F., Verweij N., Wang X., Zhang W., Kelly TN, Saleheen D., Lehne B., Leach IM, Drong AW, Abbott J., Wahl S., Tan ST, Scott WR, Campanella G., Chadeau-Hyam M., Afzal U., Ahluwalia TS, Bonder MJ, et al. Nature genetics, 2015/09/21, (2015) Read More / View Supplemental Materials
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Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history.Tada, H., Melander O., Louie JZ, Catanese JJ, Rowland CM, Devlin JJ, Kathiresan S., and Shiffman D. European heart journal, 2015/09/20, (2015) Read More / View Supplemental Materials
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Genetic research in autism spectrum disorders.Robinson, EB, Neale BM, and Hyman SE Current opinion in pediatrics, 2015/09/18, (2015) Read More / View Supplemental Materials
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In vivo Monitoring of Transcriptional Dynamics After Lower-Limb Muscle Injury Enables Quantitative Classification of Healing.Aguilar, CA, Shcherbina A., Ricke DO, Pop R., Carrigan CT, Gifford CA, Urso ML, Kottke MA, and Meissner A. Scientific reports, 2015/09/18, Volume 5, p.13885, (2015) Read More / View Supplemental Materials
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Genetic influences on the neural and physiological bases of acute threat: A research domain criteria (RDoC) perspective.Sumner, JA, Powers A., Jovanovic T., and Koenen KC American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2015/09/17, (2015) Read More / View Supplemental Materials
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Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: a Mendelian randomisation study.Yarwood, A., Viatte S., Okada Y., Plenge R., Yamamoto K., BRAGGSS RACI, Barton A., Symmons D., Raychaudhuri S., Klareskog L., Gregersen P., Worthington J., and Eyre S. Annals of the rheumatic diseases, 2015/09/17, (2015) Read More / View Supplemental Materials
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Tools and best practices for data processing in allelic expression analysis.Castel, SE, Levy-Moonshine A., Mohammadi P., Banks E., and Lappalainen T. Genome biology, 2015/09/17, Volume 16, Issue 1, p.195, (2015) Read More / View Supplemental Materials
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BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.Canver, MC, Smith EC, Sher F., Pinello L., Sanjana NE, Shalem O., Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S., Kurita R., Nakamura Y., Fujiwara Y., Maeda T., Yuan GC, Zhang F., Orkin SH, and Bauer DE Nature, 2015/09/16, (2015) Read More / View Supplemental Materials
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De novo mutations in ARID1B associated with both syndromic and non-syndromic short stature.Yu, Y., Yao R., Wang L., Fan Y., Huang X., Hirschhorn J., Dauber A., and Shen Y. BMC genomics, 2015/09/16, Volume 16, Issue 1, p.701, (2015) Read More / View Supplemental Materials
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Gene-Based Meta-Analysis of Genome-Wide Association Studies Implicates New Loci Involved in Obesity.Hägg, S., Ganna A., van der Laan SW, Esko T., Pers TH, Locke AE, Berndt SI, Justice AE, Kahali B., Siemelink MA, Pasterkamp G., GIANT Consortium, Strachan DP, Speliotes EK, North KE, Loos RJ, Hirschhorn JN, Pawitan Y., and Ingelsson E. Human molecular genetics, 2015/09/16, (2015) Read More / View Supplemental Materials
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Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.Pelleau, S., Moss EL, Dhingra SK, Volney B., Casteras J., Gabryszewski SJ, Volkman SK, Wirth DF, Legrand E., Fidock DA, Neafsey DE, and Musset L. Proceedings of the National Academy of Sciences of the United States of America, 2015/09/15, Volume 112, Issue 37, p.11672-7, (2015) Read More / View Supplemental Materials
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Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes.Shukla, SA, Rooney MS, Rajasagi M., Tiao G., Dixon PM, Lawrence MS, Lane WJ, Steelman S., Sougnez C., Cibulskis K., Kiezun A., Hacohen N., Brusic V., Wu CJ, and Getz G. Nature biotechnology, 2015/09/15, (2015) Read More / View Supplemental Materials
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Host genetic variation impacts microbiome composition across human body sites.Blekhman, R., Goodrich JK, Huang K., Sun Q., Bukowski R., Bell JT, Spector TD, Keinan A., Ley RE, Gevers D., and Clark AG Genome biology, 2015/09/15, Volume 16, p.191, (2015) Read More / View Supplemental Materials
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Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.Ghani, M., Reitz C., Cheng R., Vardarajan BN, Jun G., Sato C., Naj A., Rajbhandary R., Wang LS, Valladares O., Lin CF, Larson EB, Graff-Radford NR, Evans D., De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T., Ertekin-Taner N., et al. JAMA neurology, 2015/09/14, (2015) Read More / View Supplemental Materials
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Detection of low-abundance bacterial strains in metagenomic datasets by eigengenome partitioning.Cleary, B., Brito IL, Huang K., Gevers D., Shea T., Young S., and Alm EJ Nature biotechnology, 2015/09/14, (2015) Read More / View Supplemental Materials
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Population genetic differentiation of height and body mass index across Europe.Robinson, MR, Hemani G., Medina-Gomez C., Mezzavilla M., Esko T., Shakhbazov K., Powell JE, Vinkhuyzen A., Berndt SI, Gustafsson S., Justice AE, Kahali B., Locke AE, Pers TH, Vedantam S., Wood AR, van Rheenen W., Andreassen OA, Gasparini P., Metspalu A., et al. Nature genetics, 2015/09/14, (2015) Read More / View Supplemental Materials
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Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.Zheng, HF, Forgetta V., Hsu YH, Estrada K., Rosello-Diez A., Leo PJ, Dahia CL, Park-Min KH, Tobias JH, Kooperberg C., Kleinman A., Styrkarsdottir U., Liu CT, Uggla C., Evans DS, Nielson CM, Walter K., Pettersson-Kymmer U., McCarthy S., Eriksson J., et al. Nature, 2015/09/14, (2015) Read More / View Supplemental Materials
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Zebrafish as tools for drug discovery.Macrae, CA, and Peterson RT Nature reviews. Drug discovery, 2015/09/11, (2015) Read More / View Supplemental Materials
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Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.Avraham, R., Haseley N., Brown D., Penaranda C., Jijon HB, Trombetta JJ, Satija R., Shalek AK, Xavier RJ, Regev A., and Hung DT Cell, 2015/09/10, Volume 162, Issue 6, p.1309-21, (2015) Read More / View Supplemental Materials
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Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.Johnston, AJ, Murphy KT, Jenkinson L., Laine D., Emmrich K., Faou P., Weston R., Jayatilleke KM, Schloegel J., Talbo G., Casey JL, Levina V., Wong WW, Dillon H., Sahay T., Hoogenraad J., Anderton H., Hall C., Schneider P., Tanzer M., et al. Cell, 2015/09/10, Volume 162, Issue 6, p.1365-78, (2015) Read More / View Supplemental Materials
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Mechanisms of Cancer Cell Dormancy-Another Hallmark of Cancer?Yeh, AC, and Ramaswamy S. Cancer research, 2015/09/09, (2015) Read More / View Supplemental Materials
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Phenotypic extremes in rare variant study designs.Peloso, GM, Rader DJ, Gabriel S., Kathiresan S., Daly M. J., and Neale BM European journal of human genetics : EJHG, 2015/09/09, (2015) Read More / View Supplemental Materials
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Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells.Yang, BX, El Farran CA, Guo HC, Yu T., Fang HT, Wang HF, Schlesinger S., Seah YF, Goh GY, Neo SP, Li Y., Lorincz MC, Tergaonkar V., Lim TM, Chen L., Gunaratne J., Collins JJ, Goff SP, Daley GQ, Li H., et al. Cell, 2015/09/09, (2015) Read More / View Supplemental Materials
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Combined pan-RAF and MEK inhibition overcomes multiple resistance mechanisms to selective RAF inhibitors.Whittaker, SR, Cowley GS, Wagner S., Root DE, and Garraway LA Molecular cancer therapeutics, 2015/09/08, (2015) Read More / View Supplemental Materials
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Fossil hominin shoulders support an African ape-like last common ancestor of humans and chimpanzees.Young, NM, Capellini TD, Roach NT, and Alemseged Z. Proceedings of the National Academy of Sciences of the United States of America, 2015/09/08, (2015) Read More / View Supplemental Materials
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A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.Selleck, EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B., Virgin HW, and Sibley LD mBio, 2015/09/08, Volume 6, Issue 5, (2015) Read More / View Supplemental Materials
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Cas9 gRNA engineering for genome editing, activation and repression.Kiani, S., Chavez A., Tuttle M., Hall RN, Chari R., Ter-Ovanesyan D., Qian J., Pruitt BW, Beal J., Vora S., Buchthal J., Kowal EJ, Ebrahimkhani MR, Collins JJ, Weiss R., and Church G. Nature methods, 2015/09/07, (2015) Read More / View Supplemental Materials
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ConStrains identifies microbial strains in metagenomic datasets.Luo, C., Knight R., Siljander H., Knip M., Xavier RJ, and Gevers D. Nature biotechnology, 2015/09/07, (2015) Read More / View Supplemental Materials
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Modeling psychiatric disorders for developing effective treatments.Kaiser, T., and Feng G. Nature medicine, 2015/09/04, Volume 21, Issue 9, p.979-88, (2015) Read More / View Supplemental Materials
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A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation.Sun, J., Bonaguidi MA, Jun H., Guo JU, Sun GJ, Will B., Yang Z., Jang MH, Song H., Ming GL, and Christian KM Molecular brain, 2015/09/04, Volume 8, Issue 1, p.52, (2015) Read More / View Supplemental Materials
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Theory of mind network activity is altered in subjects with familial liability for schizophrenia.Mohnke, S., Erk S., Schnell K., Romanczuk-Seiferth N., Schmierer P., Romund L., Garbusow M., Wackerhagen C., Ripke S., Grimm O., Haller L., Witt SH, Degenhardt F., Tost H., Heinz A., Meyer-Lindenberg A., and Walter H. Social cognitive and affective neuroscience, 2015/09/04, (2015) Read More / View Supplemental Materials
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Comparative Analysis of Gene Regulatory Networks: From Network Reconstruction to Evolution.Thompson, D., Regev A., and Roy S. Annual review of cell and developmental biology, 2015/09/03, (2015) Read More / View Supplemental Materials
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Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders.Hyman, SE Cell stem cell, 2015/09/03, Volume 17, Issue 3, p.253-4, (2015) Read More / View Supplemental Materials
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Identification of an oncogenic RAB protein.Wheeler, DB, Zoncu R., Root DE, Sabatini DM, and Sawyers CL Science (New York, N.Y.), 2015/09/03, (2015) Read More / View Supplemental Materials
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Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance.Li, M., Luo XJ, Landén M., Bergen SE, Hultman CM, Li X., Zhang W., Yao YG, Zhang C., Liu J., Mattheisen M., Cichon S., Mühleisen TW, Degenhardt FA, Nöthen MM, Schulze TG, Grigoroiu-Serbanescu M., Li H., Fuller CK, Chen C., et al. The British journal of psychiatry : the journal of mental science, 2015/09/03, (2015) Read More / View Supplemental Materials
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Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma.Sim, K., Graef AJ, Breen M., Lindblad-Toh K., Modiano JF, and Kim JH Veterinary and comparative oncology, 2015/09/03, (2015) Read More / View Supplemental Materials
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Sequence-Level Analysis of the Major European Huntington Disease Haplotype.Lee, JM, Kim KH, Shin A., Chao MJ, Abu Elneel K., Gillis T., Mysore JS, Kaye JA, Zahed H., Kratter IH, Daub AC, Finkbeiner S., Li H., Roach JC, Goodman N., Hood L., Myers RH, Macdonald ME, and Gusella JF American journal of human genetics, 2015/09/03, Volume 97, Issue 3, p.435-44, (2015) Read More / View Supplemental Materials
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Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans.Hsu, YH, Liu Y., Hannan MT, Maixner W., Smith SB, Diatchenko L., Golightly YM, Menz HB, Kraus VB, Doherty M., Wilson AG, and Jordan JM Journal of medical genetics, 2015/09/02, (2015) Read More / View Supplemental Materials
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SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.Gan, W., Dai X., Lunardi A., Li Z., Inuzuka H., Liu P., Varmeh S., Zhang J., Cheng L., Sun Y., Asara JM, Beck AH, Huang J., Pandolfi PP, and Wei W. Molecular cell, 2015/09/02, (2015) Read More / View Supplemental Materials
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Deep, Quantitative Coverage of the Lysine Acetylome Using Novel Anti-acetyl-lysine Antibodies and an Optimized Proteomic Workflow.Svinkina, T., Gu H., Silva JC, Mertins P., Qiao J., Fereshetian S., Jaffe JD, Kuhn E., Udeshi ND, and Carr SA Molecular & cellular proteomics : MCP, 2015/09/01, Volume 14, Issue 9, p.2429-40, (2015) Read More / View Supplemental Materials
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Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.Nühs, A., De Rycker M., Manthri S., Comer E., Scherer CA, Schreiber SL, Ioset JR, and Gray DW PLoS neglected tropical diseases, 2015/09/01, Volume 9, Issue 9, p.e0004094, (2015) Read More / View Supplemental Materials
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Epidemiologic Investigation of a Cluster of Neuroinvasive Bacillus cereus Infections in 5 Patients With Acute Myelogenous Leukemia.Rhee, C., Klompas M., Tamburini FB, Fremin BJ, Chea N., Epstein L., Halpin AL, Guh A., Gallen R., Coulliette A., Gee J., Hsieh C., Desjardins CA, Pedamullu CS, DeAngelo DJ, Manzo VE, Folkerth RD, Milner DA Jr, Pecora N., Osborne M., et al. Open forum infectious diseases, 2015/09/01, Volume 2, Issue 3, p.ofv096, (2015) Read More / View Supplemental Materials
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Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal.Cohen, KA, Abeel T., Manson McGuire A., Desjardins CA, Munsamy V., Shea TP, Walker BJ, Bantubani N., Almeida DV, Alvarado L., Chapman SB, Mvelase NR, Duffy EY, FitzGerald MG, Govender P., Gujja S., Hamilton S., Howarth C., Larimer JD, Maharaj K., et al. PLoS medicine, 2015/09/01, Volume 12, Issue 9, p.e1001880, (2015) Read More / View Supplemental Materials
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Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii.Farrer, RA, Desjardins CA, Sakthikumar S., Gujja S., Saif S., Zeng Q., Chen Y., Voelz K., Heitman J., May RC, Fisher MC, and Cuomo CA mBio, 2015/09/01, Volume 6, Issue 5, (2015) Read More / View Supplemental Materials
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Genome-wide Polygenic Burden of Rare Deleterious Variants in Sudden Unexpected Death in Epilepsy.Leu, C., Balestrini S., Maher B., Hernández-Hernández L., Gormley P., Hämäläinen E., Heggeli K., Schoeler N., Novy J., Willis J., Plagnol V., Ellis R., Reavey E., O'Regan M., Pickrell WO, Thomas RH, Chung SK, Delanty N., McMahon JM, Malone S., et al. EBioMedicine, 2015/09/01, Volume 2, Issue 9, p.1063-70, (2015) Read More / View Supplemental Materials
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High loading of polygenic risk in cases with chronic schizophrenia.Meier, SM, Agerbo E., Maier R., Pedersen CB, Lang M., Grove J., Hollegaard MV, Demontis D., Trabjerg BB, Hjorthøj C., Ripke S., Degenhardt F., Nöthen MM, Rujescu D., Maier W., MooDS SCZ Consortium, Werge T., Mors O., Hougaard DM, Børglum AD, et al. Molecular psychiatry, 2015/09/01, (2015) Read More / View Supplemental Materials
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Inherited CHST11/MIR3922 deletion is associated with a novel recessive syndrome presenting with skeletal malformation and malignant lymphoproliferative disease.Chopra, SS, Leshchiner I., Duzkale H., McLaughlin H., Giovanni M., Zhang C., Stitziel N., Fingeroth J., Joyce RM, Lebo M., Rehm H., Vuzman D., Maas R., Sunyaev SR, Murray M., and Cassa CA Molecular genetics & genomic medicine, 2015/09/01, Volume 3, Issue 5, p.413-23, (2015) Read More / View Supplemental Materials
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Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.Abbatiello, SE, Schilling B., Mani D. R., Zimmerman LJ, Hall SC, Maclean B., Albertolle M., Allen S., Burgess M., Cusack MP, Gosh M., Hedrick V., Held JM, Inerowicz HD, Jackson A., Keshishian H., Kinsinger CR, Lyssand J., Makowski L., Mesri M., et al. Molecular & cellular proteomics : MCP, 2015/09/01, Volume 14, Issue 9, p.2357-74, (2015) Read More / View Supplemental Materials
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The metabolomics of asthma control: a promising link between genetics and disease.McGeachie, MJ, Dahlin A., Qiu W., Croteau-Chonka DC, Savage J., Wu AC, Wan ES, Sordillo JE, Al-Garawi A., Martinez FD, Strunk RC, Lemanske RF Jr, Liu AH, Raby BA, Weiss S., Clish CB, and Lasky-Su JA Immunity, inflammation and disease, 2015/09/01, Volume 3, Issue 3, p.224-38, (2015) Read More / View Supplemental Materials
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The molecular era of the mitochondrial calcium uniporter.Kamer, KJ, and Mootha VK Nature reviews. Molecular cell biology, 2015/09/01, Volume 16, Issue 9, p.545-53, (2015) Read More / View Supplemental Materials
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Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.Keshishian, H., Burgess MW, Gillette MA, Mertins P., Clauser KR, Mani D. R., Kuhn EW, Farrell LA, Gerszten RE, and Carr SA Molecular & cellular proteomics : MCP, 2015/09/01, Volume 14, Issue 9, p.2375-93, (2015) Read More / View Supplemental Materials
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Ribosomopathies: how a common root can cause a tree of pathologies.Danilova, N., and Gazda HT Disease models & mechanisms, 2015/09/01, Volume 8, Issue 9, p.1013-26, (2015) Read More / View Supplemental Materials
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Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.Yang, J., Bakshi A., Zhu Z., Hemani G., Vinkhuyzen AA, Lee SH, Robinson MR, Perry JR, Nolte IM, van Vliet-Ostaptchouk JV, Snieder H., study LifeLines Cohort, Esko T., Milani L., Mägi R., Metspalu A., Hamsten A., Magnusson PK, Pedersen NL, Ingelsson E., et al. Nature genetics, 2015/08/31, (2015) Read More / View Supplemental Materials
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The Genetics of Stress-Related Disorders: PTSD, Depression and Anxiety Disorders.Smoller, JW Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015/08/31, (2015) Read More / View Supplemental Materials
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Sequence Analysis and Characterization of Active Human Alu subfamilies Based on the 1000 Genomes Pilot Project.Konkel, MK, Walker JA, Hotard AB, Ranck MC, Fontenot CC, Storer J., Stewart C., Marth GT, 1000 Genomes Consortium, and Batzer MA Genome biology and evolution, 2015/08/29, (2015) Read More / View Supplemental Materials
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Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation.Zhang, Z., Boskovic Z., Hussain MM, Hu W., Inouye C., Kim HJ, Abole AK, Doud MK, Lewis TA, Koehler AN, Schreiber SL, and Tjian R. eLife, 2015/08/28, Volume 4, (2015) Read More / View Supplemental Materials
Abstract
EHMT1 and EHMT2 inhibition induce fetal hemoglobin expression.Renneville, A., van Galen P., Canver MC, McConkey M., Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, and Ebert BL Blood, 2015/08/28, (2015) Read More / View Supplemental Materials
Abstract
Ethnically shared and heterogeneous impacts of molecular pathways suggested by the genome-wide meta-analysis of rheumatoid arthritis.Okada, Y., Raj T., and Yamamoto K. Rheumatology (Oxford, England), 2015/08/28, (2015) Read More / View Supplemental Materials
In vitro and in vivo reprogramming for the conduction system.Macrae, CA Trends in cardiovascular medicine, 2015/08/28, (2015) Read More / View Supplemental Materials
Transgenic labeling of parvalbumin-expressing neurons with tdTomato.Kaiser, T., Ting JT, Monteiro P., and Feng G. Neuroscience, 2015/08/28, (2015) Read More / View Supplemental Materials
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Crystal Structure of Staphylococcus aureus Cas9.Nishimasu, H., Cong L., Yan WX, Ran FA, Zetsche B., Li Y., Kurabayashi A., Ishitani R., Zhang F., and Nureki O. Cell, 2015/08/27, Volume 162, Issue 5, p.1113-26, (2015) Read More / View Supplemental Materials
Abstract
Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis.Hiraki, M., Hwang SY, Cao S., Ramadhar TR, Byun S., Yoon KW, Lee JH, Chu K., Gurkar AU, Kolev V., Zhang J., Namba T., Murphy ME, Newman DJ, Mandinova A., Clardy J., and Lee SW Chemistry & biology, 2015/08/27, (2015) Read More / View Supplemental Materials
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Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis.Mima, K., Nishihara R., Qian ZR, Cao Y., Sukawa Y., Nowak JA, Yang J., Dou R., Masugi Y., Song M., Kostic AD, Giannakis M., Bullman S., Milner DA, Baba H., Giovannucci EL, Garraway LA, Freeman GJ, Dranoff G., Garrett WS, et al. Gut, 2015/08/26, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy.Ng, SY, Soh BS, Rodriguez-Muela N., Hendrickson DG, Price F., Rinn JL, and Rubin LL Cell stem cell, 2015/08/26, (2015) Read More / View Supplemental Materials
Abstract
Commissural functional topography of the inferior colliculus assessed in vitro.Lee, CC, Yanagawa Y., and Imaizumi K. Hearing research, 2015/08/25, (2015) Read More / View Supplemental Materials
Abstract
Comparative genomics of Fusarium oxysporum f. sp. melonis reveals the secreted protein recognized by the Fom-2 resistance gene in melon.Schmidt, SM, Lukasiewicz J., Farrer R., van Dam P., Bertoldo C., and Rep M. The New phytologist, 2015/08/25, (2015) Read More / View Supplemental Materials
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Genetic association analyses highlight biological pathways underlying mitral valve prolapse.Dina, C., Bouatia-Naji N., Tucker N., Delling FN, Toomer K., Durst R., Perrocheau M., Fernandez-Friera L., Solis J., investigators PROMESA, Le Tourneau T., Chen MH, Probst V., Bosse Y., Pibarot P., Zelenika D., Lathrop M., Hercberg S., Roussel R., Benjamin EJ, et al. Nature genetics, 2015/08/24, (2015) Read More / View Supplemental Materials
Abstract
In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer.Janiszewska, M., Liu L., Almendro V., Kuang Y., Paweletz C., Sakr RA, Weigelt B., Hanker AB, Chandarlapaty S., King TA, Reis-Filho JS, Arteaga CL, Park SY, Michor F., and Polyak K. Nature genetics, 2015/08/24, (2015) Read More / View Supplemental Materials
Abstract
A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors.Nishi, Y., Zhang X., Jeong J., Peterson KA, Vedenko A., Bulyk ML, Hide WA, and McMahon AP Development (Cambridge, England), 2015/08/20, (2015) Read More / View Supplemental Materials
Abstract
Mutations in PIGY: expanding the phenotype of inherited glycosylphosphatidylinositol (GPI) deficiencies.Ilkovski, B., Pagnamenta AT, O'Grady GL, Kinoshita T., Howard MF, Lek M., Thomas B., Turner A., Christodoulou J., Sillence D., Knight SJ, Popitsch N., Keays DA, Anzilotti C., Goriely A., Waddell LB, Brilot F., North KN, Kanzawa N., Macarthur DG, et al. Human molecular genetics, 2015/08/20, (2015) Read More / View Supplemental Materials
Abstract
Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.Schweitzer, LD, Comb WC, Bar-Peled L., and Sabatini DM Cell reports, 2015/08/19, (2015) Read More / View Supplemental Materials
Abstract
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.Claussnitzer, M., Dankel SN, Kim KH, Quon G., Meuleman W., Haugen C., Glunk V., Sousa IS, Beaudry JL, Puviindran V., Abdennur NA, Liu J., Svensson PA, Hsu YH, Drucker DJ, Mellgren G., Hui CC, Hauner H., and Kellis M. The New England journal of medicine, 2015/08/19, (2015) Read More / View Supplemental Materials
Abstract
PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells.Das, PP, Hendrix DA, Apostolou E., Buchner AH, Canver MC, Beyaz S., Ljuboja D., Kuintzle R., Kim W., Karnik R., Shao Z., Xie H., Xu J., De Los Angeles A., Zhang Y., Choe J., Jun DL, Shen X., Gregory RI, Daley GQ, et al. Cell reports, 2015/08/19, (2015) Read More / View Supplemental Materials
Abstract
Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population.Xu, Q., Wu X., Li M., Huang H., Minica C., Yi Z., Wang G., Shen L., Xing Q., Shi Y., He L., and Qin S. The pharmacogenomics journal, 2015/08/18, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.Hayes, MG, Urbanek M., Ehrmann DA, Armstrong LL, Lee JY, Sisk R., Karaderi T., Barber TM, McCarthy MI, Franks S., Lindgren CM, Welt CK, Diamanti-Kandarakis E., Panidis D., Goodarzi MO, Azziz R., Zhang Y., James RG, Olivier M., Kissebah AH, et al. Nature communications, 2015/08/18, Volume 6, p.7502, (2015) Read More / View Supplemental Materials
Abstract
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.Lee, SH, Byrne EM, Hultman CM, Kähler A., Vinkhuyzen AA, Ripke S., Andreassen OA, Frisell T., Gusev A., Hu X., Karlsson R., Mantzioris VX, McGrath JJ, Mehta D., Stahl EA, Zhao Q., Kendler KS, Sullivan PF, Price AL, O'Donovan M., et al. International journal of epidemiology, 2015/08/18, (2015) Read More / View Supplemental Materials
Abstract
Systematic chromatin state comparison of epigenomes associated with diverse properties including sex and tissue type.Yen, A., and Kellis M. Nature communications, 2015/08/18, Volume 6, p.7973, (2015) Read More / View Supplemental Materials
Abstract
Clinical Effects of Phosphodiesterase 3A Mutations in Inherited Hypertension With Brachydactyly.Toka, O., Tank J., Schächterle C., Aydin A., Maass PG, Elitok S., Bartels-Klein E., Hollfinger I., Lindschau C., Mai K., Boschmann M., Rahn G., Movsesian MA, Müller T., Doescher A., Gnoth S., Mühl A., Toka HR, Wefeld-Neuenfeld Y., Utz W., et al. Hypertension, 2015/08/17, (2015) Read More / View Supplemental Materials
Abstract
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