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2016
Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth.Cox, AG, Hwang KL, Brown KK, Evason KJ, Beltz S., Tsomides A., O'Connor K., Galli GG, Yimlamai D., Chhangawala S., Yuan M., Lien EC, Wucherpfennig J., Nissim S., Minami A., Cohen DE, Camargo FD, Asara JM, Houvras Y., Stainier DY, et al. Nature cell biology, 2016/07/18, (2016) Read More / View Supplemental Materials
Abstract
Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.Kar, SP, Beesley J., Amin Al Olama A., Michailidou K., Tyrer J., Kote-Jarai Z., Lawrenson K., Lindstrom S., Ramus SJ, Thompson DJ, ABCTB Investigators, Kibel AS, Dansonka-Mieszkowska A., Michael A., Dieffenbach AK, Gentry-Maharaj A., Whittemore AS, Wolk A., Monteiro A., Peixoto A., et al. Cancer discovery, 2016/07/17, (2016) Read More / View Supplemental Materials
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Association of Exome Sequences with Cardiovascular Traits among African Americans in the Jackson Heart Study.Peloso, GM, Lange LA, Varga TV, Nickerson DA, Smith JD, Griswold ME, Musani S., Polfus LM, Mei H., Gabriel S., Quarells RC, Altshuler D., Boerwinkle E., Daly M. J., Neale B., Correa A., Reiner AP, Wilson JG, and Kathiresan S. Circulation. Cardiovascular genetics, 2016/07/15, (2016) Read More / View Supplemental Materials
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Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci.Walford, GA, Gustafsson S., Rybin D., Stančáková A., Chen H., Liu CT, Hong J., Jensen RA, Rice K., Morris AP, Mägi R., Tönjes A., Prokopenko I., Kleber ME, Delgado G., Silbernagel G., Jackson AU, Appel EV, Grarup N., Lewis JP, et al. Diabetes, 2016/07/14, (2016) Read More / View Supplemental Materials
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Ipilimumab for Patients with Relapse after Allogeneic Transplantation.Davids, MS, Kim HT, Bachireddy P., Costello C., Liguori R., Savell A., Lukez AP, Avigan D., Chen YB, McSweeney P., LeBoeuf NR, Rooney MS, Bowden M., Zhou CW, Granter SR, Hornick JL, Rodig SJ, Hirakawa M., Severgnini M., Hodi FS, et al. The New England journal of medicine, 2016/07/14, Volume 375, Issue 2, p.143-53, (2016) Read More / View Supplemental Materials
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CRISPR Screens to Discover Functional Noncoding Elements.Wright, JB, and Sanjana NE Trends in genetics : TIG, 2016/07/13, (2016) Read More / View Supplemental Materials
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Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease.Shaw, KA, Bertha M., Hofmekler T., Chopra P., Vatanen T., Srivatsa A., Prince J., Kumar A., Sauer C., Zwick ME, Satten GA, Kostic AD, Mulle JG, Xavier RJ, and Kugathasan S. Genome medicine, 2016/07/13, Volume 8, Issue 1, p.75, (2016) Read More / View Supplemental Materials
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Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.Burberry, A., Suzuki N., Wang JY, Moccia R., Mordes DA, Stewart MH, Suzuki-Uematsu S., Ghosh S., Singh A., Merkle FT, Koszka K., Li QZ, Zon L., Rossi DJ, Trowbridge JJ, Notarangelo LD, and Eggan K. Science translational medicine, 2016/07/13, Volume 8, Issue 347, p.347ra93, (2016) Read More / View Supplemental Materials
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Mobile genes in the human microbiome are structured from global to individual scales.Brito, IL, Yilmaz S., Huang K., Xu L., Jupiter SD, Jenkins AP, Naisilisili W., Tamminen M., Smillie CS, Wortman JR, Birren BW, Xavier RJ, Blainey PC, Singh AK, Gevers D., and Alm EJ Nature, 2016/07/13, (2016) Read More / View Supplemental Materials
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Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation.Loscertales, M., Nicolaou F., Jeanne M., Longoni M., Gould DB, Sun Y., Maalouf FI, Nagy N., and Donahoe PK BMC biology, 2016/07/13, Volume 14, Issue 1, p.59, (2016) Read More / View Supplemental Materials
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Uncovering the Role of the Methylome in Dementia and Neurodegeneration.Klein, HU, and De Jager PL Trends in molecular medicine, 2016/07/13, (2016) Read More / View Supplemental Materials
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Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia.Legge, SE, Hamshere ML, Ripke S., Pardinas AF, Goldstein JI, Rees E., Richards AL, Leonenko G., Jorskog LF, Clozapine-Induced Agranulocytosis Consortium, Chambert KD, Collier DA, Genovese G., Giegling I., Holmans P., Jonasdottir A., Kirov G., McCarroll SA, MacCabe JH, Mantripragada K., et al. Molecular psychiatry, 2016/07/12, (2016) Read More / View Supplemental Materials
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Joint Bayesian inference of risk variants and tissue-specific epigenomic enrichments across multiple complex human diseases.Li, Y., and Kellis M. Nucleic acids research, 2016/07/12, (2016) Read More / View Supplemental Materials
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Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes.Fall, T., Salihovic S., Brandmaier S., Nowak C., Ganna A., Gustafsson S., Broeckling CD, Prenni JE, Kastenmüller G., Peters A., Magnusson PK, Wang-Sattler R., Giedraitis V., Berne C., Gieger C., Pedersen NL, Ingelsson E., and Lind L. Diabetologia, 2016/07/12, (2016) Read More / View Supplemental Materials
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V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A Synthetic Modified mRNA Drives Reprogramming of Human Pancreatic Duct-Derived Cells Into Insulin-Secreting Cells.Corritore, E., Lee YS, Pasquale V., Liberati D., Hsu MJ, Lombard CA, Van Der Smissen P., Vetere A., Bonner-Weir S., Piemonti L., Sokal E., and Lysy P. Stem cells translational medicine, 2016/07/12, (2016) Read More / View Supplemental Materials
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The genetic architecture of type 2 diabetes.Fuchsberger, C., Flannick J., Teslovich TM, Mahajan A., Agarwala V., Gaulton KJ, Ma C., Fontanillas P., Moutsianas L., McCarthy DJ, Rivas MA, Perry JR, Sim X., Blackwell TW, Robertson NR, Rayner NW, Cingolani P., Locke AE, Tajes JF, Highland HM, et al. Nature, 2016/07/11, (2016) Read More / View Supplemental Materials
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An Outbreak of Ebola Virus Disease in the Lassa Fever Zone.Goba, A., Khan SH, Fonnie M., Fullah M., Moigboi A., Kovoma A., Sinnah V., Yoko N., Rogers H., Safai S., Momoh M., Koroma V., Kamara FK, Konowu E., Yillah M., French I., Mustapha I., Kanneh F., Foday M., McCarthy H., et al. The Journal of infectious diseases, 2016/07/11, (2016) Read More / View Supplemental Materials
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Type 2 diabetes: genetic data sharing to advance complex disease research.Flannick, J., and Florez JC Nature reviews. Genetics, 2016/07/11, (2016) Read More / View Supplemental Materials
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Estrogen-related receptor gamma implicated in a phenotype including hearing loss and mild developmental delay.Schilit, SL, Currall BB, Yao R., Hanscom C., Collins RL, Pillalamarri V., Lee DY, Kammin T., Zepeda-Mendoza CJ, Mononen T., Nolan LS, Gusella JF, Talkowski ME, Shen J., and Morton CC European journal of human genetics : EJHG, 2016/07/06, (2016) Read More / View Supplemental Materials
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Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma.Powers, JT, Tsanov KM, Pearson DS, Roels F., Spina CS, Ebright R., Seligson M., de Soysa Y., Cahan P., Theißen J., Tu HC, Han A., Kurek KC, LaPier GS, Osborne JK, Ross SJ, Cesana M., Collins JJ, Berthold F., and Daley GQ Nature, 2016/07/06, Volume 535, Issue 7611, p.246-51, (2016) Read More / View Supplemental Materials
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Polygenic risk of Alzheimer disease is associated with early- and late-life processes.Mormino, EC, Sperling RA, Holmes AJ, Buckner RL, De Jager PL, Smoller JW, Sabuncu MR, and Alzheimer's Disease Neuroimaging Initiative Neurology, 2016/07/06, (2016) Read More / View Supplemental Materials
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Association of a Genetic Risk Score With Body Mass Index Across Different Birth Cohorts.Walter, S., Mejía-Guevara I., Estrada K., Liu SY, and Glymour MM JAMA, 2016/07/05, Volume 316, Issue 1, p.63-9, (2016) Read More / View Supplemental Materials
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A Child's HLA-DRB1 genotype increases maternal risk of systemic lupus erythematosus.Cruz, GI, Shao X., Quach H., Ho KA, Sterba K., Noble JA, Patsopoulos NA, Busch MP, Triulzi DJ, Wong WS, Solomon BD, Niederhuber JE, Criswell LA, and Barcellos LF Journal of autoimmunity, 2016/07/04, (2016) Read More / View Supplemental Materials
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Ebola Virus Epidemiology and Evolution in Nigeria.Folarin, OA, Ehichioya D., Schaffner SF, Winnicki SM, Wohl S., Eromon P., West KL, Gladden-Young A., Oyejide NE, Matranga CB, Deme AB, James A., Tomkins-Tinch C., Onyewurunwa K., Ladner JT, Palacios G., Nosamiefan I., Andersen KG, Omilabu S., Park DJ, et al. The Journal of infectious diseases, 2016/07/04, (2016) Read More / View Supplemental Materials
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Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.Li, Y., Oosting M., Deelen P., Ricaño-Ponce I., Smeekens S., Jaeger M., Matzaraki V., Swertz MA, Xavier RJ, Franke L., Wijmenga C., Joosten LA, Kumar V., and Netea MG Nature medicine, 2016/07/04, (2016) Read More / View Supplemental Materials
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The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis.Ben-David, U., Ha G., Khadka P., Jin X., Wong B., Franke L., and Golub T. R. Nature communications, 2016/07/04, Volume 7, p.12160, (2016) Read More / View Supplemental Materials
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SwiSpot: Modeling Riboswitches by Spotting Out Switching Sequences.Barsacchi, M., Novoa EM, Kellis M., and Bechini A. Bioinformatics (Oxford, England), 2016/07/04, (2016) Read More / View Supplemental Materials
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Atrial fibrillation without comorbidities: Prevalence, incidence and prognosis (from the Framingham Heart Study).Kim, EJ, Yin X., Fontes JD, Magnani JW, Lubitz SA, McManus DD, Seshadri S., Vasan RS, Ellinor PT, Larson MG, Benjamin EJ, and Rienstra M. American heart journal, 2016/07/01, Volume 177, p.138-44, (2016) Read More / View Supplemental Materials
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Catechol-O-methyltransferase association with hemoglobin A1c.Hall, KT, Jablonski KA, Chen L., Harden M., Tolkin BR, Kaptchuk TJ, Bray GA, Ridker PM, Florez JC, Diabetes Prevention Program Research Group, Mukamal KJ, and Chasman DI Metabolism: clinical and experimental, 2016/07/01, Volume 65, Issue 7, p.961-7, (2016) Read More / View Supplemental Materials
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Control theory meets synthetic biology.Del Vecchio, D., Dy AJ, and Qian Y. Journal of the Royal Society, Interface / the Royal Society, 2016/07/01, Volume 13, Issue 120, (2016) Read More / View Supplemental Materials
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De novo frameshift mutation in COUP-TFII (NR2F2) in human congenital diaphragmatic hernia.High, FA, Bhayani P., Wilson JM, Bult CJ, Donahoe PK, and Longoni M. American journal of medical genetics. Part A, 2016/07/01, (2016) Read More / View Supplemental Materials
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Exome sequencing results in successful diagnosis and treatment of a severe congenital anemia.Lacy, JN, Ulirsch JC, Grace RF, Towne MC, Hale J., Mohandas N., Lux SE 4th, Agrawal PB, and Sankaran VG Cold Spring Harbor molecular case studies, 2016/07/01, Volume 2, Issue 4, p.a000885, (2016) Read More / View Supplemental Materials
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A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GMCSF.Chuang, LS, Villaverde N., Hui KY, Mortha A., Rahman A., Levine AP, Haritunians T., Ng SM, Zhang W., Hsu NY, Facey JA, Luong T., Fernandez-Hernandez H., Li D., Rivas M., Schiff ER, Gusev A., Schumm LP, Bowen BM, Sharma Y., et al. Gastroenterology, 2016/07/01, (2016) Read More / View Supplemental Materials
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The Genetic Landscape of β-Cell Proliferation: Toward a Road Map.Wagner, BK Diabetes, 2016/07/01, Volume 65, Issue 7, p.1789-90, (2016) Read More / View Supplemental Materials
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.Stein, MB, Chen CY, Ursano RJ, Cai T., Gelernter J., Heeringa SG, Jain S., Jensen KP, Maihofer AX, Mitchell C., Nievergelt CM, Nock MK, Neale BM, Polimanti R., Ripke S., Sun X., Thomas ML, Wang Q., Ware EB, Borja S., et al. JAMA psychiatry, 2016/07/01, Volume 73, Issue 7, p.695-704, (2016) Read More / View Supplemental Materials
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Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.Mitchell, JS, Li N., Weinhold N., Försti A., Ali M., van Duin M., Thorleifsson G., Johnson DC, Chen B., Halvarsson BM, Gudbjartsson DF, Kuiper R., Stephens OW, Bertsch U., Broderick P., Campo C., Einsele H., Gregory WA, Gullberg U., Henrion M., et al. Nature communications, 2016/07/01, Volume 7, p.12050, (2016) Read More / View Supplemental Materials
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Juicebox Provides a Visualization System for Hi-C Contact Maps with Unlimited Zoom.Durand, NC, Robinson JT, Shamim MS, Machol I., Mesirov J. P., Lander E. S., and Aiden EL Cell systems, 2016/07/01, Volume 3, Issue 1, p.99-101, (2016) Read More / View Supplemental Materials
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Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments.Durand, NC, Shamim MS, Machol I., Rao SS, Huntley MH, Lander E. S., and Aiden EL Cell systems, 2016/07/01, Volume 3, Issue 1, p.95-8, (2016) Read More / View Supplemental Materials
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Leveraging Genetics to Advance Type 2 Diabetes Prevention.Florez, JC PLoS medicine, 2016/07/01, Volume 13, Issue 7, p.e1002102, (2016) Read More / View Supplemental Materials
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Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies.Dang, M., Henderson RE, Garraway LA, and Zon LI Disease models & mechanisms, 2016/07/01, Volume 9, Issue 7, p.811-20, (2016) Read More / View Supplemental Materials
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.Van Voorhis, WC, Adams JH, Adelfio R., Ahyong V., Akabas MH, Alano P., Alday A., Alemán Resto Y., Alsibaee A., Alzualde A., Andrews KT, Avery SV, Avery VM, Ayong L., Baker M., Baker S., Ben Mamoun C., Bhatia S., Bickle Q., Bounaadja L., et al. PLoS pathogens, 2016/07/01, Volume 12, Issue 7, p.e1005763, (2016) Read More / View Supplemental Materials
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Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder.Huang, JH, Berkovitch SS, Iaconelli J., Watmuff B., Park H., Chattopadhyay S., McPhie D., Öngür D., Cohen BM, Clish CB, and Karmacharya R. Molecular neuropsychiatry, 2016/07/01, Volume 2, Issue 2, p.97-106, (2016) Read More / View Supplemental Materials
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Prostate Cancer Susceptibility in Men of African Ancestry at 8q24.Han, Y., Rand KA, Hazelett DJ, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B., Isaacs WB, Stanford JL, Zheng W., Schumacher FR, Berndt SI, Wang Z., Xu J., Rohland N., Reich D., Tandon A., Pasaniuc B., Allen A., et al. Journal of the National Cancer Institute, 2016/07/01, Volume 108, Issue 7, (2016) Read More / View Supplemental Materials
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Relation of genomic variants for Alzheimer disease dementia to common neuropathologies.Farfel, JM, Yu L., Buchman AS, Schneider JA, De Jager PL, and Bennett DA Neurology, 2016/07/01, (2016) Read More / View Supplemental Materials
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Whole-Exome Sequencing in Two Extreme Phenotypes of Response to VEGF-Targeted Therapies in Patients With Metastatic Clear Cell Renal Cell Carcinoma.Fay, AP, De Velasco G., Ho TH, Van Allen EM, Murray B., Albiges L., Signoretti S., Hakimi AA, Stanton ML, Bellmunt J., McDermott DF, Atkins MB, Garraway LA, Kwiatkowski DJ, and Choueiri TK Journal of the National Comprehensive Cancer Network : JNCCN, 2016/07/01, Volume 14, Issue 7, p.820-4, (2016) Read More / View Supplemental Materials
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Roots, Not Parachutes: Research Collaborations Combat Outbreaks.Yozwiak, NL, Happi CT, Grant DS, Schieffelin JS, Garry RF, Sabeti PC, and Andersen KG Cell, 2016/06/30, Volume 166, Issue 1, p.5-8, (2016) Read More / View Supplemental Materials
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Use of Multiple Sequencing Technologies To Produce a High-Quality Genome of the Fungus Pseudogymnoascus destructans, the Causative Agent of Bat White-Nose Syndrome.Drees, KP, Palmer JM, Sebra R., Lorch JM, Chen C., Wu CC, Bok JW, Keller NP, Blehert DS, Cuomo CA, Lindner DL, and Foster JT Genome announcements, 2016/06/30, Volume 4, Issue 3, (2016) Read More / View Supplemental Materials
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Multiple regulatory variants located in cell type-specific enhancers within the PKP2 locus form major risk and protective haplotypes for canine atopic dermatitis in German shepherd dogs.Tengvall, K., Kozyrev S., Kierczak M., Bergvall K., Farias FH, Ardesjö-Lundgren B., Olsson M., Murén E., Hagman R., Leeb T., Pielberg G., Hedhammar Å., Andersson G., and Lindblad-Toh K. BMC genetics, 2016/06/29, Volume 17, Issue 1, p.97, (2016) Read More / View Supplemental Materials
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Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.Guaitoli, G., Raimondi F., Gilsbach BK, Gómez-Llorente Y., Deyaert E., Renzi F., Li X., Schaffner A., Jagtap PK, Boldt K., von Zweydorf F., Gotthardt K., Lorimer DD, Yue Z., Burgin A., Janjic N., Sattler M., Versées W., Ueffing M., Ubarretxena-Belandia I., et al. Proceedings of the National Academy of Sciences of the United States of America, 2016/06/29, (2016) Read More / View Supplemental Materials
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Association of tumour microRNA profiling with outcomes in patients with advanced urothelial carcinoma receiving first-line platinum-based chemotherapy.Bellmunt, J., Zhou CW, Mullane SA, Werner L., Taplin ME, Fay AP, Choueiri TK, Orsola A., Takeda DY, Hahn WC, Kim J., Sonpavde G., and Bowden M. British journal of cancer, 2016/06/28, Volume 115, Issue 1, p.12-9, (2016) Read More / View Supplemental Materials
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Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.Lenz, TL, Spirin V., Jordan DM, and Sunyaev SR Molecular biology and evolution, 2016/06/28, (2016) Read More / View Supplemental Materials
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A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries.Mann, AP, Scodeller P., Hussain S., Joo J., Kwon E., Braun GB, Mölder T., She ZG, Kotamraju VR, Ranscht B., Krajewski S., Teesalu T., Bhatia S., Sailor MJ, and Ruoslahti E. Nature communications, 2016/06/28, Volume 7, p.11980, (2016) Read More / View Supplemental Materials
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The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis.Gibson, WJ, Hoivik EA, Halle MK, Taylor-Weiner A., Cherniack AD, Berg A., Holst F., Zack TI, Werner HM, Staby KM, Rosenberg M., Stefansson IM, Kusonmano K., Chevalier A., Mauland KK, Trovik J., Krakstad C., Giannakis M., Hodis E., Woie K., et al. Nature genetics, 2016/06/27, (2016) Read More / View Supplemental Materials
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Hydrophobic CDR3 residues promote the development of self-reactive T cells.Stadinski, BD, Shekhar K., Gómez-Touriño I., Jung J., Sasaki K., Sewell AK, Peakman M., Chakraborty AK, and Huseby ES Nature immunology, 2016/06/27, (2016) Read More / View Supplemental Materials
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Information recovery from low coverage whole-genome bisulfite sequencing.Libertini, E., Heath SC, Hamoudi RA, Gut M., Ziller MJ, Czyz A., Ruotti V., Stunnenberg HG, Frontini M., Ouwehand WH, Meissner A., Gut IG, and Beck S. Nature communications, 2016/06/27, Volume 7, p.11306, (2016) Read More / View Supplemental Materials
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Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax.Hupalo, DN, Luo Z., Melnikov A., Sutton PL, Rogov P., Escalante A., Vallejo AF, Herrera S., Arévalo-Herrera M., Fan Q., Wang Y., Cui L., Lucas CM, Durand S., Sanchez JF, Baldeviano GC, Lescano AG, Laman M., Barnadas C., Barry A., et al. Nature genetics, 2016/06/27, (2016) Read More / View Supplemental Materials
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Saturation analysis for whole-genome bisulfite sequencing data.Libertini, E., Heath SC, Hamoudi RA, Gut M., Ziller MJ, Herrero J., Czyz A., Ruotti V., Stunnenberg HG, Frontini M., Ouwehand WH, Meissner A., Gut IG, and Beck S. Nature biotechnology, 2016/06/27, (2016) Read More / View Supplemental Materials
Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents.Verderosa, AD, Mansour SC, de la Fuente-Núñez C., Hancock RE, and Fairfull-Smith KE Molecules (Basel, Switzerland), 2016/06/27, Volume 21, Issue 7, (2016) Read More / View Supplemental Materials
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CellProfiler Analyst: interactive data exploration, analysis, and classification of large biological image sets.Dao, D., Fraser AN, Hung J., Ljosa V., Singh S., and Carpenter AE Bioinformatics (Oxford, England), 2016/06/26, (2016) Read More / View Supplemental Materials
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Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology.Adams, SL, Tilton K., Kozubek JA, Seshadri S., and Delalle I. Journal of neuropathology and experimental neurology, 2016/06/26, (2016) Read More / View Supplemental Materials
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Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury.Subramanian, B., Sun H., Yan P., Charoonratana VT, Higgs HN, Wang F., Lai KV, Valenzuela DM, Brown EJ, Schlöndorff JS, and Pollak MR Kidney international, 2016/06/24, (2016) Read More / View Supplemental Materials
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Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors.Grant, SS, Wellington S., Kawate T., Desjardins CA, Silvis MR, Wivagg C., Thompson M., Gordon K., Kazyanskaya E., Nietupski R., Haseley N., Iwase N., Earl AM, FitzGerald M., and Hung DT Cell chemical biology, 2016/06/23, Volume 23, Issue 6, p.666-77, (2016) Read More / View Supplemental Materials
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Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.Jarvis, D., Mitchell JS, Law PJ, Palin K., Tuupanen S., Gylfe A., Hänninen UA, Cajuso T., Tanskanen T., Kondelin J., Kaasinen E., Sarin AP, Kaprio J., Eriksson JG, Rissanen H., Knekt P., Pukkala E., Jousilahti P., Salomaa V., Ripatti S., et al. British journal of cancer, 2016/06/23, (2016) Read More / View Supplemental Materials
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Integrated genetic and pharmacologic interrogation of rare cancers.Hong, AL, Tseng YY, Cowley GS, Jonas O., Cheah JH, Kynnap BD, Doshi MB, Oh C., Meyer SC, Church AJ, Gill S., Bielski CM, Keskula P., Imamovic A., Howell S., Kryukov GV, Clemons PA, Tsherniak A., Vazquez F., Crompton BD, et al. Nature communications, 2016/06/22, Volume 7, p.11987, (2016) Read More / View Supplemental Materials
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Microfluidic neurite guidance to study structure-function relationships in topologically-complex population-based neural networks.Honegger, T., Thielen MI, Feizi S., Sanjana NE, and Voldman J. Scientific reports, 2016/06/22, Volume 6, p.28384, (2016) Read More / View Supplemental Materials
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RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression.Meyer Zu Horste, G., Wu C., Wang C., Cong L., Pawlak M., Lee Y., Elyaman W., Xiao S., Regev A., and Kuchroo VK Cell reports, 2016/06/22, (2016) Read More / View Supplemental Materials
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Development of autologous blood cell therapies.Kim, AR, and Sankaran VG Experimental hematology, 2016/06/21, (2016) Read More / View Supplemental Materials
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Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.Chami, N., Chen MH, Slater AJ, Eicher JD, Evangelou E., Tajuddin SM, Love-Gregory L., Kacprowski T., Schick UM, Nomura A., Giri A., Lessard S., Brody JA, Schurmann C., Pankratz N., Yanek LR, Manichaikul A., Pazoki R., Mihailov E., Hill WD, et al. American journal of human genetics, 2016/06/21, (2016) Read More / View Supplemental Materials
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Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.Hou, L., Bergen SE, Akula N., Song J., Hultman CM, Landén M., Adli M., Alda M., Ardau R., Arias B., Aubry JM, Backlund L., Badner JA, Barrett TB, Bauer M., Baune BT, Bellivier F., Benabarre A., Bengesser S., Berrettini WH, et al. Human molecular genetics, 2016/06/21, (2016) Read More / View Supplemental Materials
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GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.Matteini, AM, Tanaka T., Karasik D., Atzmon G., Chou WC, Eicher JD, Johnson AD, Arnold AM, Callisaya ML, Davies G., Evans DS, Holtfreter B., Lohman K., Lunetta KL, Mangino M., Smith AV, Smith JA, Teumer A., Yu L., Arking DE, et al. Aging cell, 2016/06/21, (2016) Read More / View Supplemental Materials
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Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases.Tajuddin, SM, Schick UM, Eicher JD, Chami N., Giri A., Brody JA, Hill WD, Kacprowski T., Li J., Lyytikäinen LP, Manichaikul A., Mihailov E., O'Donoghue ML, Pankratz N., Pazoki R., Polfus LM, Smith AV, Schurmann C., Vacchi-Suzzi C., Waterworth DM, et al. American journal of human genetics, 2016/06/21, (2016) Read More / View Supplemental Materials
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Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.Eicher, JD, Chami N., Kacprowski T., Nomura A., Chen MH, Yanek LR, Tajuddin SM, Schick UM, Slater AJ, Pankratz N., Polfus L., Schurmann C., Giri A., Brody JA, Lange LA, Manichaikul A., Hill WD, Pazoki R., Elliot P., Evangelou E., et al. American journal of human genetics, 2016/06/21, (2016) Read More / View Supplemental Materials
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Science Signaling Podcast for 21 June 2016: Nanoparticles to treat type 1 diabetes.Quintana, FJ, and VanHook AM Science signaling, 2016/06/21, Volume 9, Issue 433, p.pc15, (2016) Read More / View Supplemental Materials
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Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2.Yeste, A., Takenaka MC, Mascanfroni ID, Nadeau M., Kenison JE, Patel B., Tukpah AM, Babon JA, DeNicola M., Kent SC, Pozo D., and Quintana FJ Science signaling, 2016/06/21, Volume 9, Issue 433, p.ra61, (2016) Read More / View Supplemental Materials
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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.Gormley, P., Anttila V., Winsvold BS, Palta P., Esko T., Pers TH, Farh KH, Cuenca-Leon E., Muona M., Furlotte NA, Kurth T., Ingason A., McMahon G., Ligthart L., Terwindt GM, Kallela M., Freilinger TM, Ran C., Gordon SG, Stam AH, et al. Nature genetics, 2016/06/20, (2016) Read More / View Supplemental Materials
Abstract
Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAP kinase pathway mutations.Louissaint A, Jr, Schafernak KT, Geyer J., Kovach AE, Ghandi M., Gratzinger D., Roth CG, Paxton CN, Kim S., Namgyal C., Morgan EA, Neuberg DS, South ST, Harris MH, Hasserjian RP, Hochberg EP, Garraway LA, Harris NL, and Weinstock DM Blood, 2016/06/20, (2016) Read More / View Supplemental Materials
Abstract
Targeting MTHFD2 in acute myeloid leukemia.Pikman, Y., Puissant A., Alexe G., Furman A., Chen LM, Frumm SM, Ross L., Fenouille N., Bassil CF, Lewis CA, Ramos A., Gould J., Stone RM, DeAngelo DJ, Galinsky I., Clish CB, Kung AL, Hemann MT, Vander Heiden MG, Banerji V., et al. The Journal of experimental medicine, 2016/06/20, (2016) Read More / View Supplemental Materials
Abstract
ARGON: fast, whole-genome simulation of the discrete time Wright-Fisher process.Palamara, PF Bioinformatics (Oxford, England), 2016/06/16, (2016) Read More / View Supplemental Materials
Abstract
Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling.Hwang, SY, Deng X., Byun S., Lee C., Lee SJ, Suh H., Zhang J., Kang Q., Zhang T., Westover KD, Mandinova A., and Lee SW Cell reports, 2016/06/16, (2016) Read More / View Supplemental Materials
Abstract
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.Strong, R., Miller RA, Antebi A., Astle CM, Bogue M., Denzel MS, Fernandez E., Flurkey K., Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Marinez PA, McCord JM, Miller BF, Müller M., Nelson JF, Ndukum J., Rainger GE, Richardson A., et al. Aging cell, 2016/06/16, (2016) Read More / View Supplemental Materials
Abstract
Mitochondrial dysfunction remodels one-carbon metabolism in human cells.Bao, XR, Ong SE, Goldberger O., Peng J., Sharma R., Thompson DA, Vafai SB, Cox AG, Marutani E., Ichinose F., Goessling W., Regev A., Carr SA, Clish CB, and Mootha VK eLife, 2016/06/16, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
A broad analysis of resistance development in the malaria parasite.Corey, VC, Lukens AK, Istvan ES, Lee MC, Franco V., Magistrado P., Coburn-Flynn O., Sakata-Kato T., Fuchs O., Gnädig NF, Goldgof G., Linares M., Gomez-Lorenzo MG, De Cózar C., Lafuente-Monasterio MJ, Prats S., Meister S., Tanaseichuk O., Wree M., Zhou Y., et al. Nature communications, 2016/06/15, Volume 7, p.11901, (2016) Read More / View Supplemental Materials
Abstract
LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.Zhang, J., Ratanasirintrawoot S., Chandrasekaran S., Wu Z., Ficarro SB, Yu C., Ross CA, Cacchiarelli D., Xia Q., Seligson M., Shinoda G., Xie W., Cahan P., Wang L., Ng SC, Tintara S., Trapnell C., Onder T., Loh YH, Mikkelsen T., et al. Cell stem cell, 2016/06/15, (2016) Read More / View Supplemental Materials
Abstract
Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability.Yassour, M., Vatanen T., Siljander H., Hämäläinen AM, Härkönen T., Ryhänen SJ, Franzosa EA, Vlamakis H., Huttenhower C., Gevers D., Lander E. S., Knip M., DIABIMMUNE Study Group, and Xavier RJ Science translational medicine, 2016/06/15, Volume 8, Issue 343, p.343ra81, (2016) Read More / View Supplemental Materials
Abstract
Rhinovirus and serum IgE are associated with acute asthma exacerbation severity in children.Kantor, DB, Stenquist N., McDonald MC, Schultz BJ, Hauptman M., Smallwood CD, Nelson KA, Perzanowski MS, Matsui EC, Phipatanakul W., and Hirschhorn JN The Journal of allergy and clinical immunology, 2016/06/15, (2016) Read More / View Supplemental Materials
Trans-ethnic Meta-Analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.Liu, CT, Raghavan S., Maruthur N., Kabagambe EK, Hong J., Ng MC, Hivert MF, Lu Y., An P., Bentley AR, Drolet AM, Gaulton KJ, Guo X., Armstrong LL, Irvin MR, Li M., Lipovich L., Rybin DV, Taylor KD, Agyemang C., et al. American journal of human genetics, 2016/06/15, (2016) Read More / View Supplemental Materials
Abstract
Using genomic annotations increases statistical power to detect eGenes.Duong, D., Zou J., Hormozdiari F., Sul JH, Ernst J., Han B., and Eskin E. Bioinformatics (Oxford, England), 2016/06/15, Volume 32, Issue 12, p.i156-i163, (2016) Read More / View Supplemental Materials
Abstract
Engineering a perfusable 3D human liver platform from iPS cells.Schepers, A., Li C., Chhabra A., Seney BT, and Bhatia S. Lab on a chip, 2016/06/14, (2016) Read More / View Supplemental Materials
Abstract
Orosomucoid, Carotid Plaque, and Incidence of Stroke.Berntsson, J., Östling G., Persson M., Smith JG, Hedblad B., and Engström G. Stroke; a journal of cerebral circulation, 2016/06/14, (2016) Read More / View Supplemental Materials
Abstract
Differential associations between systemic markers of disease and white matter tissue health in middle-aged and older adults.Ryu, CW, Coutu JP, Greka A., Rosas HD, Jahng GH, Rosen BR, and Salat DH Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016/06/13, (2016) Read More / View Supplemental Materials
Abstract
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome.Machiela, MJ, Zhou W., Karlins E., Sampson JN, Freedman ND, Yang Q., Hicks B., Dagnall C., Hautman C., Jacobs KB, Abnet CC, Aldrich MC, Amos C., Amundadottir LT, Arslan AA, Beane-Freeman LE, Berndt SI, Black A., Blot WJ, Bock CH, et al. Nature communications, 2016/06/13, Volume 7, p.11843, (2016) Read More / View Supplemental Materials
Abstract
A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse.Lemieux, JE, Tran AD, Freimark L., Schaffner SF, Goethert H., Andersen KG, Bazner S., Li A., McGrath G., Sloan L., Vannier E., Milner D., Pritt B., Rosenberg E., Telford S 3rd, Bailey JA, and Sabeti PC Nature microbiology, 2016/06/13, Volume 1, Issue 7, p.16079, (2016) Read More / View Supplemental Materials
Abstract
Risk Factors Associated With Early vs Delayed Dementia After Intracerebral Hemorrhage.Biffi, A., Bailey D., Anderson CD, Ayres AM, Gurol EM, Greenberg SM, Rosand J., and Viswanathan A. JAMA neurology, 2016/06/13, (2016) Read More / View Supplemental Materials
Abstract
Precision Medicine in Diabetes: Is It Time?Florez, JC Diabetes care, 2016/06/11, (2016) Read More / View Supplemental Materials
De Novo Lipogenesis Products and Endogenous Lipokines.Yilmaz, M., Claiborn KC, and Hotamisligil GS Diabetes, 2016/06/10, (2016) Read More / View Supplemental Materials
Abstract
Internal guide RNA interactions interfere with Cas9-mediated cleavage.Thyme, SB, Akhmetova L., Montague TG, Valen E., and Schier AF Nature communications, 2016/06/10, Volume 7, p.11750, (2016) Read More / View Supplemental Materials
Abstract
BRAT1 mutations present with a spectrum of clinical severity.Srivastava, S., Olson HE, Cohen JS, Gubbels CS, Lincoln S., Davis BT, Shahmirzadi L., Gupta S., Picker J., Yu TW, Miller DT, Soul JS, Poretti A., and Naidu S. American journal of medical genetics. Part A, 2016/06/09, (2016) Read More / View Supplemental Materials
Abstract
Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent.Wimalasena, NK, Le VQ, Wimalasena K., Schreiber SL, and Karmacharya R. ACS chemical neuroscience, 2016/06/09, (2016) Read More / View Supplemental Materials
Abstract
RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming.Toh, CD, Chan JW, Chong ZS, Wang HF, Guo HC, Satapathy S., Ma D., Goh GY, Khattar E., Yang L., Tergaonkar V., Chang YT, Collins JJ, Daley GQ, Wee KB, Farran CA, Li H., Lim YP, Bard FA, and Loh YH Cell reports, 2016/06/08, (2016) Read More / View Supplemental Materials
Abstract
The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1.Boada-Romero, E., Serramito-Gómez I., Sacristán MP, Boone DL, Xavier RJ, and Pimentel-Muiños FX Nature communications, 2016/06/08, Volume 7, p.11821, (2016) Read More / View Supplemental Materials
Abstract
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