Scientific Publications

Search by Keyword(s)
Found 3626 results

Search Results

  • Showing 201-300 of 3626 Results
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7...
2016
Genomic copy number dictates a gene-independent cell response to CRISPR-Cas9 targeting.Aguirre, AJ, Meyers RM, Weir BA, Vazquez F., Zhang CZ, Ben-David U., Cook A., Ha G., Harrington WF, Doshi MB, Kost-Alimova M., Gill S., Xu H., Ali LD, Jiang G., Pantel S., Lee Y., Goodale A., Cherniack AD, Oh C., et al. Cancer discovery, 2016/06/03, (2016) Read More / View Supplemental Materials
Abstract
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.Abudayyeh, OO, Gootenberg JS, Konermann S., Joung J., Slaymaker IM, Cox DB, Shmakov S., Makarova KS, Semenova E., Minakhin L., Severinov K., Regev A., Lander E. S., Koonin EV, and Zhang F. Science (New York, N.Y.), 2016/06/02, (2016) Read More / View Supplemental Materials
Abstract
"Cat's Cradling" the 3D Genome by the Act of LncRNA Transcription.Melé, M., and Rinn JL Molecular cell, 2016/06/02, Volume 62, Issue 5, p.657-64, (2016) Read More / View Supplemental Materials
Abstract
Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.Tewhey, R., Kotliar D., Park DS, Liu B., Winnicki S., Reilly SK, Andersen KG, Mikkelsen TS, Lander E. S., Schaffner SF, and Sabeti PC Cell, 2016/06/02, Volume 165, Issue 6, p.1519-29, (2016) Read More / View Supplemental Materials
Abstract
Distinct Genetic Profiles of Extracranial and Intracranial Acral Melanoma Metastases.Sharma, G., Lian CG, Lin WM, Amin-Mansour A., Jané-Valbuena J., Garraway L., Bao W., Yoon CH, and Ibrahim N. Journal of cutaneous pathology, 2016/06/02, (2016) Read More / View Supplemental Materials
Abstract
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate.Sleiman, SF, Henry J., Al-Haddad R., El Hayek L., Abou Haidar E., Stringer T., Ulja D., Karuppagounder SS, Holson EB, Ratan RR, Ninan I., and Chao MV eLife, 2016/06/02, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
Genomic Dark Matter Illuminated: Anopheles Y Chromosomes.Redmond, SN, and Neafsey DE Trends in parasitology, 2016/06/02, (2016) Read More / View Supplemental Materials
Abstract
Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.Etchegaray, JP, and Mostoslavsky R. Molecular cell, 2016/06/02, Volume 62, Issue 5, p.695-711, (2016) Read More / View Supplemental Materials
Abstract
Systematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits.Ulirsch, JC, Nandakumar SK, Wang L., Giani FC, Zhang X., Rogov P., Melnikov A., McDonel P., Do R., Mikkelsen TS, and Sankaran VG Cell, 2016/06/02, Volume 165, Issue 6, p.1530-45, (2016) Read More / View Supplemental Materials
Abstract
Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation.Schnabel, RB, Maas R., Wang N., Yin X., Larson MG, Levy D., Ellinor PT, Lubitz SA, McManus DD, Magnani JW, Atzler D., Böger RH, Schwedhelm E., Vasan RS, and Benjamin EJ American heart journal, 2016/06/01, Volume 176, p.100-6, (2016) Read More / View Supplemental Materials
Abstract
Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder.Yoshimi, N., Futamura T., Kakumoto K., Salehi AM, Sellgren CM, Holmén-Larsson J., Jakobsson J., Pålsson E., Landén M., and Hashimoto K. BBA clinical, 2016/06/01, Volume 5, p.151-8, (2016) Read More / View Supplemental Materials
Abstract
Circulating Metabolites and Survival Among Patients With Pancreatic Cancer.Yuan, C., Clish CB, Wu C., Mayers JR, Kraft P., Townsend MK, Zhang M., Tworoger SS, Bao Y., Qian ZR, Rubinson DA, Ng K., Giovannucci EL, Ogino S., Stampfer MJ, Gaziano JM, Ma J., Sesso HD, Anderson GL, Cochrane BB, et al. Journal of the National Cancer Institute, 2016/06/01, Volume 108, Issue 6, (2016) Read More / View Supplemental Materials
Abstract
Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion.Capellera-Garcia, S., Pulecio J., Dhulipala K., Siva K., Rayon-Estrada V., Singbrant S., Sommarin MN, Walkley CR, Soneji S., Karlsson G., Raya Á., Sankaran VG, and Flygare J. Cell reports, 2016/06/01, (2016) Read More / View Supplemental Materials
Abstract
Discovery of rare variants for complex phenotypes.Kosmicki, JA, Churchhouse CL, Rivas MA, and Neale BM Human genetics, 2016/06/01, Volume 135, Issue 6, p.625-34, (2016) Read More / View Supplemental Materials
Abstract
Exome Sequencing of Familial Bipolar Disorder.Goes, FS, Pirooznia M., Parla JS, Kramer M., Ghiban E., Mavruk S., Chen YC, Monson ET, Willour VL, Karchin R., Flickinger M., Locke AE, Levy SE, Scott LJ, Boehnke M., Stahl E., Moran JL, Hultman CM, Landén M., Purcell SM, et al. JAMA psychiatry, 2016/06/01, Volume 73, Issue 6, p.590-7, (2016) Read More / View Supplemental Materials
Abstract
Genome editing: Broad Institute keeps CRISPR tools open.McGuire, L. Nature, 2016/06/01, Volume 534, Issue 7605, p.37, (2016) Read More / View Supplemental Materials
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.Scott, RA, Freitag DF, Li L., Chu AY, Surendran P., Young R., Grarup N., Stancáková A., Chen Y., Varga TV, Yaghootkar H., Luan J., Zhao JH, Willems SM, Wessel J., Wang S., Maruthur N., Michailidou K., Pirie A., van der Lee SJ, et al. Science translational medicine, 2016/06/01, Volume 8, Issue 341, p.341ra76, (2016) Read More / View Supplemental Materials
Abstract
Glyco-centric lectin magnetic bead array (LeMBA) - proteomics dataset of human serum samples from healthy, Barrett׳s esophagus and esophageal adenocarcinoma individuals.Shah, AK, Lê Cao KA, Choi E., Chen D., Gautier B., Nancarrow D., Whiteman DC, Baker PR, Clauser KR, Chalkley RJ, Saunders NA, Barbour AP, Joshi V., and Hill MM Data in brief, 2016/06/01, Volume 7, p.1058-62, (2016) Read More / View Supplemental Materials
Abstract
Inhibition of DYRK1A Stimulates Human β-Cell Proliferation.Dirice, E., Walpita D., Vetere A., Meier BC, Kahraman S., Hu J., Dančík V., Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, and Wagner BK Diabetes, 2016/06/01, Volume 65, Issue 6, p.1660-71, (2016) Read More / View Supplemental Materials
Abstract
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.Prins, BP, Abbasi A., Wong A., Vaez A., Nolte I., Franceschini N., Stuart PE, Guterriez Achury J., Mistry V., Bradfield JP, Valdes AM, Bras J., Shatunov A., PAGE Consortium, International Stroke Genetics Consortium, consortium Systemic Sclerosis, consortium Treat OA, DIAGRAM Consortium, CARDIOGRAMplusC4D Consortium, consortium ALS, et al. PLoS medicine, 2016/06/01, Volume 13, Issue 6, p.e1001976, (2016) Read More / View Supplemental Materials
Abstract
Network Analysis of Genome-Wide Selective Constraint Reveals a Gene Network Active in Early Fetal Brain Intolerant of Mutation.Choi, J., Shooshtari P., Samocha KE, Daly M. J., and Cotsapas C. PLoS genetics, 2016/06/01, Volume 12, Issue 6, p.e1006121, (2016) Read More / View Supplemental Materials
Abstract
NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.Ali, YO, Allen HM, Yu L., Li-Kroeger D., Bakhshizadehmahmoudi D., Hatcher A., McCabe C., Xu J., Bjorklund N., Taglialatela G., Bennett DA, De Jager PL, Shulman JM, Bellen HJ, and Lu HC PLoS biology, 2016/06/01, Volume 14, Issue 6, p.e1002472, (2016) Read More / View Supplemental Materials
Abstract
Erratum to: Host lifestyle affects human microbiota on daily timescales.David, LA, Materna AC, Friedman J., Baptista MI, Blackburn MC, Perrotta A., Erdman SE, and Alm EJ Genome biology, 2016/05/31, Volume 17, Issue 1, p.117, (2016) Read More / View Supplemental Materials
Genomic determinants of cancer immunotherapy.Miao, D., and Van Allen EM Current opinion in immunology, 2016/05/30, Volume 41, p.32-38, (2016) Read More / View Supplemental Materials
Abstract
Genotyping of relapsing polychondritis identified novel susceptibility HLA alleles and distinct genetic characteristics from other rheumatic diseases.Terao, C., Yoshifuji H., Yamano Y., Kojima H., Yurugi K., Miura Y., Maekawa T., Handa H., Ohmura K., Saji H., Mimori T., and Matsuda F. Rheumatology (Oxford, England), 2016/05/30, (2016) Read More / View Supplemental Materials
Abstract
Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.Bruni, G., Rennekamp AJ, Velenich A., McCarroll M., Gendelev L., Fertsch E., Taylor J., Lakhani P., Lensen D., Evron T., Lorello PJ, Huang XP, Kolczewski S., Carey G., Caldarone BJ, Prinssen E., Roth BL, Keiser MJ, Peterson RT, and Kokel D. Nature chemical biology, 2016/05/30, (2016) Read More / View Supplemental Materials
Abstract
σ1 receptor ligands control a switch between passive and active threat responses.Rennekamp, AJ, Huang XP, Wang Y., Patel S., Lorello PJ, Cade L., Gonzales AP, Yeh JJ, Caldarone BJ, Roth BL, Kokel D., and Peterson RT Nature chemical biology, 2016/05/30, (2016) Read More / View Supplemental Materials
Abstract
Differentiation-related glycan epitopes identify discrete domains of the muscle glycocalyx.McMorran, BJ, McCarthy FE, Gibbs EM, Pang M., Marshall JL, Nairn AV, Moremen KW, Crosbie-Watson RH, and Baum LG Glycobiology, 2016/05/28, (2016) Read More / View Supplemental Materials
Abstract
An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group.Sung, YJ, Winkler TW, Manning AK, Aschard H., Gudnason V., Harris TB, Smith AV, Boerwinkle E., Brown MR, Morrison AC, Fornage M., Lin LA, Richard M., Bartz TM, Psaty BM, Hayward C., Polasek O., Marten J., Rudan I., Feitosa MF, et al. Genetic epidemiology, 2016/05/27, (2016) Read More / View Supplemental Materials
Abstract
Gut microbiota, metabolites and host immunity.Rooks, MG, and Garrett WS Nature reviews. Immunology, 2016/05/27, Volume 16, Issue 6, p.341-52, (2016) Read More / View Supplemental Materials
Abstract
An RNA-aptamer-based two-color CRISPR labeling system.Wang, S., Hsu J., Zhang F., and Zhuang X. Scientific reports, 2016/05/27, Volume 6, p.26857, (2016) Read More / View Supplemental Materials
Abstract
Submaximal Exercise Systolic Blood Pressure and Heart Rate at 20 Years of Follow-up: Correlates in the Framingham Heart Study.Spartano, NL, Lyass A., Larson MG, Lewis GD, and Vasan RS Journal of the American Heart Association, 2016/05/27, Volume 5, Issue 6, (2016) Read More / View Supplemental Materials
Abstract
Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans.Leach, MD, Farrer RA, Tan K., Miao Z., Walker LA, Cuomo CA, Wheeler RT, Brown AJ, Wong KH, and Cowen LE Nature communications, 2016/05/26, Volume 7, p.11704, (2016) Read More / View Supplemental Materials
Abstract
Whole organism lineage tracing by combinatorial and cumulative genome editing.McKenna, A., Findlay GM, Gagnon JA, Horwitz MS, Schier AF, and Shendure J. Science (New York, N.Y.), 2016/05/26, (2016) Read More / View Supplemental Materials
Abstract
Proteogenomics connects somatic mutations to signalling in breast cancer.Mertins, P., Mani D. R., Ruggles KV, Gillette MA, Clauser KR, Wang P., Wang X., Qiao JW, Cao S., Petralia F., Kawaler E., Mundt F., Krug K., Tu Z., Lei JT, Gatza ML, Wilkerson M., Perou CM, Yellapantula V., Huang KL, et al. Nature, 2016/05/25, Volume 534, Issue 7605, p.55-62, (2016) Read More / View Supplemental Materials
Abstract
Regulation of the T Cell Response by CD39.Takenaka, MC, Robson S., and Quintana FJ Trends in immunology, 2016/05/25, (2016) Read More / View Supplemental Materials
Abstract
Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing.O'Connell, DJ, Kolde R., Sooknah M., Graham DB, Sundberg TB, Latorre IJ, Mikkelsen TS, and Xavier RJ Cell systems, 2016/05/25, Volume 2, Issue 5, p.323-34, (2016) Read More / View Supplemental Materials
Abstract
Chemogenomics and orthology-based design of antibiotic combination therapies.Chandrasekaran, S., Cokol-Cakmak M., Sahin N., Yilancioglu K., Kazan H., Collins JJ, and Cokol M. Molecular systems biology, 2016/05/24, Volume 12, Issue 5, p.872, (2016) Read More / View Supplemental Materials
Abstract
Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish.Chew, GL, Pauli A., and Schier AF Nature communications, 2016/05/24, Volume 7, p.11663, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.Power, RA, Tansey KE, Buttenschøn HN, Cohen-Woods S., Bigdeli T., Hall LS, Kutalik Z., Lee SH, Ripke S., Steinberg S., Teumer A., Viktorin A., Wray NR, Arolt V., Baune BT, Boomsma DI, Børglum AD, Byrne EM, Castelao E., Craddock N., et al. Biological psychiatry, 2016/05/24, (2016) Read More / View Supplemental Materials
Abstract
TOR1AIP1 as a cause of cardiac failure and recessive limb-girdle muscular dystrophy.Ghaoui, R., Benavides T., Lek M., Waddell LB, Kaur S., North KN, Macarthur DG, Clarke NF, and Cooper ST Neuromuscular disorders : NMD, 2016/05/24, (2016) Read More / View Supplemental Materials
Abstract
TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer.Groner, AC, Cato L., de Tribolet-Hardy J., Bernasocchi T., Janouskova H., Melchers D., Houtman R., Cato AC, Tschopp P., Gu L., Corsinotti A., Zhong Q., Fankhauser C., Fritz C., Poyet C., Wagner U., Guo T., Aebersold R., Garraway LA, Wild PJ, et al. Cancer cell, 2016/05/24, (2016) Read More / View Supplemental Materials
Abstract
Comparison of Cas9 activators in multiple species.Chavez, A., Tuttle M., Pruitt BW, Ewen-Campen B., Chari R., Ter-Ovanesyan D., Haque SJ, Cecchi RJ, Kowal EJ, Buchthal J., Housden BE, Perrimon N., Collins JJ, and Church G. Nature methods, 2016/05/23, (2016) Read More / View Supplemental Materials
Abstract
Recent Advances in Defining the Genetic Basis of Rheumatoid Arthritis.Terao, C., Raychaudhuri S., and Gregersen PK Annual review of genomics and human genetics, 2016/05/23, (2016) Read More / View Supplemental Materials
Abstract
Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition.Burger, JA, Landau DA, Taylor-Weiner A., Bozic I., Zhang H., Sarosiek K., Wang L., Stewart C., Fan J., Hoellenriegel J., Sivina M., Dubuc AM, Fraser C., Han Y., Li S., Livak KJ, Zou L., Wan Y., Konoplev S., Sougnez C., et al. Nature communications, 2016/05/20, Volume 7, p.11589, (2016) Read More / View Supplemental Materials
Abstract
Mechanisms of Pediatric Inflammatory Bowel Disease.Peloquin, JM, Goel G., Villablanca EJ, and Xavier RJ Annual review of immunology, 2016/05/20, Volume 34, p.31-64, (2016) Read More / View Supplemental Materials
Abstract
Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease.Dumanski, JP, Lambert JC, Rasi C., Giedraitis V., Davies H., Grenier-Boley B., Lindgren CM, Campion D., Dufouil C., European Alzheimer’s Disease Initiative Investigators, Pasquier F., Amouyel P., Lannfelt L., Ingelsson M., Kilander L., Lind L., and Forsberg LA American journal of human genetics, 2016/05/20, (2016) Read More / View Supplemental Materials
Abstract
Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda.Chang, HH, Meibalan E., Zelin J., Daniels R., Eziefula AC, Meyer EC, Tadesse F., Grignard L., Joice RC, Drakeley C., Wirth DF, Volkman SK, Buckee C., Bousema T., and Marti M. Scientific reports, 2016/05/20, Volume 6, p.26330, (2016) Read More / View Supplemental Materials
Abstract
Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity.Sajuthi, SP, Sharma NK, Chou JW, Palmer ND, McWilliams DR, Beal J., Comeau ME, Ma L., Calles-Escandon J., Demons J., Rogers S., Cherry K., Menon L., Kouba E., Davis D., Burris M., Byerly SJ, Ng MC, Maruthur NM, Patel SR, et al. Human genetics, 2016/05/19, (2016) Read More / View Supplemental Materials
Abstract
PCSK9 Inhibitors.Natarajan, P., and Kathiresan S. Cell, 2016/05/19, Volume 165, Issue 5, p.1037, (2016) Read More / View Supplemental Materials
Abstract
The impact of the MYB-NFIB fusion protooncogene in vivo.Mikse, OR, Tchaicha JH, Akbay EA, Chen L., Bronson RT, Hammerman PS, and Wong KK Oncotarget, 2016/05/18, (2016) Read More / View Supplemental Materials
Abstract
Intracellular Action of a Secreted Peptide Required for Fungal Virulence.Homer, CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D., Upadhya R., Caradonna I., Petnic S., Pessino V., Cuomo CA, Lodge JK, Perfect J., Yates JR 3rd, Nielsen K., Craik CS, and Madhani HD Cell host & microbe, 2016/05/18, (2016) Read More / View Supplemental Materials
Abstract
The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region.Schmidt, K., Joyce CE, Buquicchio F., Brown A., Ritz J., Distel RJ, Yoon CH, and Novina CD Cell reports, 2016/05/18, (2016) Read More / View Supplemental Materials
Abstract
Role of Plasmodium vivax Duffy-binding protein 1 in invasion of Duffy-null Africans.Gunalan, K., Lo E., Hostetler JB, Yewhalaw D., Mu J., Neafsey DE, Yan G., and Miller LH Proceedings of the National Academy of Sciences of the United States of America, 2016/05/17, (2016) Read More / View Supplemental Materials
Abstract
Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer.McPherson, A., Roth A., Laks E., Masud T., Bashashati A., Zhang AW, Ha G., Biele J., Yap D., Wan A., Prentice LM, Khattra J., Smith MA, Nielsen CB, Mullaly SC, Kalloger S., Karnezis A., Shumansky K., Siu C., Rosner J., et al. Nature genetics, 2016/05/16, (2016) Read More / View Supplemental Materials
Abstract
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.Han, B., Pouget JG, Slowikowski K., Stahl E., Lee CH, Diogo D., Hu X., Park YR, Kim E., Gregersen PK, Dahlqvist SR, Worthington J., Martin J., Eyre S., Klareskog L., Huizinga T., Chen WM, Onengut-Gumuscu S., Rich SS, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, et al. Nature genetics, 2016/05/16, (2016) Read More / View Supplemental Materials
Abstract
Novel microRNA regulators of atrial natriuretic peptide production.Wu, C., Arora P., Agha O., Hurst LA, Allen K., Nathan DI, Hu D., Jiramongkolchai P., Smith JG, Melander O., Trenson S., Janssens SP, Domian I., Wang TJ, Bloch KD, Buys ES, Bloch DB, and Newton-Cheh C. Molecular and cellular biology, 2016/05/16, (2016) Read More / View Supplemental Materials
Abstract
Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy.Ivansson, EL, Megquier K., Kozyrev SV, Murén E., Körberg IB, Swofford R., Koltookian M., Tonomura N., Zeng R., Kolicheski AL, Hansen L., Katz ML, Johnson GC, Johnson GS, Coates JR, and Lindblad-Toh K. Proceedings of the National Academy of Sciences of the United States of America, 2016/05/16, (2016) Read More / View Supplemental Materials
Abstract
Hematopoietic Age at Onset of Triple-Negative Breast Cancer Dictates Disease Aggressiveness and Progression.Marsh, T., Wong I., Sceneay J., Barakat A., Qin Y., Sjödin A., Alspach E., Nilsson B., Stewart SA, and McAllister SS Cancer research, 2016/05/15, Volume 76, Issue 10, p.2932-43, (2016) Read More / View Supplemental Materials
Abstract
The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.Lutas, A., Lahmann C., Soumillon M., and Yellen G. eLife, 2016/05/13, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
Metabolomics of Chronic Kidney Disease Progression: A Case-Control Analysis in the Chronic Renal Insufficiency Cohort Study.Rhee, EP, Clish CB, Wenger J., Roy J., Elmariah S., Pierce KA, Bullock K., Anderson AH, Gerszten RE, and Feldman HI American journal of nephrology, 2016/05/13, Volume 43, Issue 5, p.366-374, (2016) Read More / View Supplemental Materials
Abstract
Associations of Trauma Exposure and Posttraumatic Stress Symptoms With Venous Thromboembolism Over 22 Years in Women.Sumner, JA, Kubzansky LD, Kabrhel C., Roberts AL, Chen Q., Winning A., Gilsanz P., Rimm EB, Glymour MM, and Koenen KC Journal of the American Heart Association, 2016/05/12, Volume 5, Issue 5, (2016) Read More / View Supplemental Materials
Abstract
Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine.Green, RC, Goddard KA, Jarvik GP, Amendola LM, Appelbaum PS, Berg JS, Bernhardt BA, Biesecker LG, Biswas S., Blout CL, Bowling KM, Brothers KB, Burke W., Caga-Anan CF, Chinnaiyan AM, Chung WK, Clayton EW, Cooper GM, East K., Evans JP, et al. American journal of human genetics, 2016/05/12, (2016) Read More / View Supplemental Materials
Abstract
YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression.Lyons, SM, Achorn C., Kedersha NL, Anderson PJ, and Ivanov P. Nucleic acids research, 2016/05/12, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide association study identifies 74 loci associated with educational attainment.Okbay, A., Beauchamp JP, Fontana MA, Lee JJ, Pers TH, Rietveld CA, Turley P., Chen GB, Emilsson V., Meddens SF, Oskarsson S., Pickrell JK, Thom K., Timshel P., de Vlaming R., Abdellaoui A., Ahluwalia TS, Bacelis J., Baumbach C., Bjornsdottir G., et al. Nature, 2016/05/11, Volume 533, Issue 7604, p.539-42, (2016) Read More / View Supplemental Materials
Abstract
Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects.Park, JG, Tischfield MA, Nugent AA, Cheng L., Di Gioia SA, Chan WM, Maconachie G., Bosley TM, Summers CG, Hunter DG, Robson CD, Gottlob I., and Engle EC American journal of human genetics, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.Dominguez-Brauer, C., Hao Z., Elia AJ, Fortin JM, Nechanitzky R., Brauer PM, Sheng Y., Mana MD, Chio II, Haight J., Pollett A., Cairns R., Tworzyanski L., Inoue S., Reardon C., Marques A., Silvester J., Cox MA, Wakeham A., Yilmaz OH, et al. Cell stem cell, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium.Amendola, LM, Jarvik GP, Leo MC, McLaughlin HM, Akkari Y., Amaral MD, Berg JS, Biswas S., Bowling KM, Conlin LK, Cooper GM, Dorschner MO, Dulik MC, Ghazani AA, Ghosh R., Green RC, Hart R., Horton C., Johnston JJ, Lebo MS, et al. American journal of human genetics, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing.Degrauwe, N., Schlumpf TB, Janiszewska M., Martin P., Cauderay A., Provero P., Riggi N., Suvà ML, Paro R., and Stamenkovic I. Cell reports, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.Kugel, S., Sebastián C., Fitamant J., Ross KN, Saha SK, Jain E., Gladden A., Arora KS, Kato Y., Rivera MN, Ramaswamy S., Sadreyev RI, Goren A., Deshpande V., Bardeesy N., and Mostoslavsky R. Cell, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures.Wang, X., Tucker NR, Rizki G., Mills R., Krijger PH, de Wit E., Subramanian V., Bartell E., Nguyen XX, Ye J., Leyton-Mange J., Dolmatova EV, van der Harst P., de Laat W., Ellinor PT, Newton-Cheh C., Milan DJ, Kellis M., and Boyer LA eLife, 2016/05/10, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits.Robinson, JE, Hastie KM, Cross RW, Yenni RE, Elliott DH, Rouelle JA, Kannadka CB, Smira AA, Garry CE, Bradley BT, Yu H., Shaffer JG, Boisen ML, Hartnett JN, Zandonatti MA, Rowland MM, Heinrich ML, Martínez-Sobrido L., Cheng B., de la Torre JC, et al. Nature communications, 2016/05/10, Volume 7, p.11544, (2016) Read More / View Supplemental Materials
Abstract
Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth.Holst, F., Hoivik EA, Gibson WJ, Taylor-Weiner A., Schumacher SE, Asmann YW, Grossmann P., Trovik J., Necela BM, Thompson EA, Meyerson M., Beroukhim R., Salvesen HB, and Cherniack AD Scientific reports, 2016/05/10, Volume 6, p.25521, (2016) Read More / View Supplemental Materials
Abstract
Adult axolotls can regenerate original neuronal diversity in response to brain injury.Amamoto, R., Huerta VG, Takahashi E., Dai G., Grant AK, Fu Z., and Arlotta P. eLife, 2016/05/09, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.Lamas, B., Richard ML, Leducq V., Pham HP, Michel ML, Da Costa G., Bridonneau C., Jegou S., Hoffmann TW, Natividad JM, Brot L., Taleb S., Couturier-Maillard A., Nion-Larmurier I., Merabtene F., Seksik P., Bourrier A., Cosnes J., Ryffel B., Beaugerie L., et al. Nature medicine, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma.Zheng, S., Cherniack AD, Dewal N., Moffitt RA, Danilova L., Murray BA, Lerario AM, Else T., Knijnenburg TA, Ciriello G., Kim S., Assie G., Morozova O., Akbani R., Shih J., Hoadley KA, Choueiri TK, Waldmann J., Mete O., Robertson AG, et al. Cancer cell, 2016/05/09, Volume 29, Issue 5, p.723-36, (2016) Read More / View Supplemental Materials
Abstract
Diagnosis and aetiology of congenital muscular dystrophy: we are halfway there.O'Grady, GL, Lek M., Lamande SR, Waddell L., Oates EC, Punetha J., Ghaoui R., Sandaradura SA, Best H., Kaur S., Davis M., Laing NG, Muntoni F., Hoffman E., Macarthur DG, Clarke NF, Cooper S., and North K. Annals of neurology, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas.Campbell, JD, Alexandrov A., Kim J., Wala J., Berger AH, Pedamallu CS, Shukla SA, Guo G., Brooks AN, Murray BA, Imielinski M., Hu X., Ling S., Akbani R., Rosenberg M., Cibulskis C., Ramachandran A., Collisson EA, Kwiatkowski DJ, Lawrence MS, et al. Nature genetics, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide association study of generalized anxiety symptoms in the Hispanic Community Health Study/Study of Latinos.Dunn, EC, Sofer T., Gallo LC, Gogarten SM, Kerr KF, Chen CY, Stein MB, Ursano RJ, Guo X., Jia Y., Qi Q., Rotter JI, Argos M., Cai J., Penedo FJ, Perreira K., Wassertheil-Smoller S., and Smoller JW American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
MAPK activation and HRAS mutation identified in pituitary spindle cell oncocytoma.Miller, MB, Bi WL, Ramkissoon LA, Kang YJ, Abedalthagafi M., Knoff DS, Agarwalla PK, Wen PY, Reardon DA, Alexander BM, Laws ER Jr, Dunn IF, Beroukhim R., Ligon KL, and Ramkissoon SH Oncotarget, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.Diaz-Horta, O., Abad C., Sennaroglu L., Foster J 2nd, DeSmidt A., Bademci G., Tokgoz-Yilmaz S., Duman D., Cengiz FB, Grati M., Fitoz S., Liu XZ, Farooq A., Imtiaz F., Currall BB, Morton CC, Nishita M., Minami Y., Lu Z., Walz K., et al. Proceedings of the National Academy of Sciences of the United States of America, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.Rothhammer, V., Mascanfroni ID, Bunse L., Takenaka MC, Kenison JE, Mayo L., Chao CC, Patel B., Yan R., Blain M., Alvarez JI, Kébir H., Anandasabapathy N., Izquierdo G., Jung S., Obholzer N., Pochet N., Clish CB, Prinz M., Prat A., et al. Nature medicine, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Comparative transcriptomics across the prokaryotic tree of life.Cohen, O., Doron S., Wurtzel O., Dar D., Edelheit S., Karunker I., Mick E., and Sorek R. Nucleic acids research, 2016/05/06, (2016) Read More / View Supplemental Materials
Abstract
Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components.Pardee, K., Green AA, Takahashi MK, Braff D., Lambert G., Lee JW, Ferrante T., Ma D., Donghia N., Fan M., Daringer NM, Bosch I., Dudley DM, O'Connor DH, Gehrke L., and Collins JJ Cell, 2016/05/06, (2016) Read More / View Supplemental Materials
Abstract
Single-molecule decoding of combinatorially modified nucleosomes.Shema, E., Jones D., Shoresh N., Donohue L., Ram O., and Bernstein BE Science (New York, N.Y.), 2016/05/06, Volume 352, Issue 6286, p.717-21, (2016) Read More / View Supplemental Materials
Abstract
An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1.Lorberbaum, DS, Ramos AI, Peterson KA, Carpenter BS, Parker DS, De S., Hillers LE, Blake VM, Nishi Y., McFarlane MR, Chiang AC, Kassis JA, Allen BL, McMahon AP, and Barolo S. eLife, 2016/05/05, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
A comparative assessment of clinical whole exome and transcriptome profiling across sequencing centers: Implications for precision cancer medicine.Allen, EM, Robinson D., Morrissey C., Pritchard C., Imamovic A., Carter S., Rosenberg M., McKenna A., Wu YM, Cao X., Chinnaiyan A., Garraway L., and Nelson PS Oncotarget, 2016/05/05, (2016) Read More / View Supplemental Materials
Abstract
CSF1R mosaicism in a family with hereditary diffuse leukoencephalopathy with spheroids.Eichler, FS, Li J., Guo Y., Caruso PA, Bjonnes AC, Pan J., Booker JK, Lane JM, Tare A., Vlasac I., Hakonarson H., Gusella JF, Zhang J., Keating BJ, and Saxena R. Brain : a journal of neurology, 2016/05/05, (2016) Read More / View Supplemental Materials
Abstract
Development and Validation of a Mass Spectrometry-Based Assay for the Molecular Diagnosis of Mucin-1 Kidney Disease.Blumenstiel, B., DeFelice M., Birsoy O., Bleyer AJ, Kmoch S., Carter TA, Gnirke A., Kidd K., Rehm HL, Ronco L., Lander E. S., Gabriel S., and Lennon NJ The Journal of molecular diagnostics : JMD, 2016/05/05, (2016) Read More / View Supplemental Materials
Abstract
Population-Scale Sequencing Data Enable Precise Estimates of Y-STR Mutation Rates.Willems, T., Gymrek M., Poznik GD, Tyler-Smith C., 1000 Genomes Project Chromosome Y Group, and Erlich Y. American journal of human genetics, 2016/05/05, Volume 98, Issue 5, p.919-33, (2016) Read More / View Supplemental Materials
Abstract
Tumour CD274 (PD-L1) expression and T cells in colorectal cancer.Masugi, Y., Nishihara R., Yang J., Mima K., da Silva A., Shi Y., Inamura K., Cao Y., Song M., Nowak JA, Liao X., Nosho K., Chan AT, Giannakis M., Bass AJ, Hodi FS, Freeman GJ, Rodig S., Fuchs CS, Qian ZR, et al. Gut, 2016/05/05, (2016) Read More / View Supplemental Materials
Abstract
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.Vatanen, T., Kostic AD, d'Hennezel E., Siljander H., Franzosa EA, Yassour M., Kolde R., Vlamakis H., Arthur TD, Hämäläinen AM, Peet A., Tillmann V., Uibo R., Mokurov S., Dorshakova N., Ilonen J., Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H., et al. Cell, 2016/05/05, Volume 165, Issue 4, p.842-53, (2016) Read More / View Supplemental Materials
Abstract
Antidepressant-like effect of low dose ketamine and scopolamine co-treatment in mice.Petryshen, TL, Lewis MC, Dennehy KA, Garza JC, and Fava M. Neuroscience letters, 2016/05/04, Volume 620, p.70-3, (2016) Read More / View Supplemental Materials
Abstract
Enrichment of rare variants in population isolates: single AICDA mutation responsible for hyper-IgM syndrome type 2 in Finland.Trotta, L., Hautala T., Hämäläinen S., Syrjänen J., Viskari H., Almusa H., Lepisto M., Kaustio M., Porkka K., Palotie A., Seppänen M., and Saarela J. European journal of human genetics : EJHG, 2016/05/04, (2016) Read More / View Supplemental Materials
Abstract
Systematic functional interrogation of rare cancer variants identifies oncogenic alleles.Kim, E., Ilic N., Shrestha Y., Zou L., Kamburov A., Zhu C., Yang X., Lubonja R., Tran N., Nguyen C., Lawrence MS, Piccioni F., Bagul M., Doench JG, Chouinard CR, Wu X., Hogstrom L., Natoli T., Tamayo P., Horn H., et al. Cancer discovery, 2016/05/04, (2016) Read More / View Supplemental Materials
Abstract
Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes.Taleban, S., Stewart KO, Li DK, Singh P., Pardi DS, Sturgeon HC, Yajnik V., Xavier RJ, Ananthakrishnan AN, and Khalili H. Digestive diseases and sciences, 2016/05/03, (2016) Read More / View Supplemental Materials
Abstract
COMT Val158 Met genotype is associated with reward learning: A replication study and meta-analysis.Corral-Frías, NS, Pizzagalli DA, Carré J., Michalski LJ, Nikolova YS, Perlis RH, Fagerness J., Lee MR, Drabant Conley E., Lancaster TM, Haddad S., Wolf A., Smoller JW, Hariri AR, and Bogdan R. Genes, brain, and behavior, 2016/05/03, (2016) Read More / View Supplemental Materials
Abstract
A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs.Raffan, E., Dennis RJ, O'Donovan CJ, Becker JM, Scott RA, Smith SP, Withers DJ, Wood CJ, Conci E., Clements DN, Summers KM, German AJ, Mellersh CS, Arendt ML, Iyemere VP, Withers E., Söder J., Wernersson S., Andersson G., Lindblad-Toh K., et al. Cell metabolism, 2016/05/02, (2016) Read More / View Supplemental Materials
Abstract
The genetic history of Ice Age Europe.Fu, Q., Posth C., Hajdinjak M., Petr M., Mallick S., Fernandes D., Furtwängler A., Haak W., Meyer M., Mittnik A., Nickel B., Peltzer A., Rohland N., Slon V., Talamo S., Lazaridis I., Lipson M., Mathieson I., Schiffels S., Skoglund P., et al. Nature, 2016/05/02, (2016) Read More / View Supplemental Materials
Abstract
A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years.Moorjani, P., Sankararaman S., Fu Q., Przeworski M., Patterson N., and Reich D. Proceedings of the National Academy of Sciences of the United States of America, 2016/05/02, (2016) Read More / View Supplemental Materials
Abstract
  • Showing 201-300 of 3626 Results
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7...