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2014
No association between RORA polymorphisms and PTSD in two independent samples.Guffanti, G., Ashley-Koch AE, Roberts AL, Garrett ME, Solovieff N., Ratanatharathorn A., De Vivo I., Dennis M., Ranu H., Smoller JW, Liu Y., Purcell SM, and Veterans Affairs Mid-Atlantic Mental Illness Research, Education Clinical Center Workgroup, Beckham J., Hauser MA, and Koenen KC Molecular psychiatry, 2014/07/22, (2014) Read More / View Supplemental Materials
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.Naba, A., Clauser KR, Whittaker CA, Carr SA, Tanabe KK, and Hynes R. O. BMC cancer, 2014/07/18, Volume 14, p.518, (2014) Read More / View Supplemental Materials
Abstract
Mitochondrial EFTs defects in juvenile-onset Leigh disease, ataxia, neuropathy, and optic atrophy.Ahola, S., Isohanni P., Euro L., Brilhante V., Palotie A., Pihko H., Lönnqvist T., Lehtonen T., Laine J., Tyynismaa H., and Suomalainen A. Neurology, 2014/07/18, (2014) Read More / View Supplemental Materials
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Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters.Cimermancic, P., Medema MH, Claesen J., Kurita K., Wieland Brown LC, Mavrommatis K., Pati A., Godfrey PA, Koehrsen M., Clardy J., Birren BW, Takano E., Sali A., Linington RG, and Fischbach MA Cell, 2014/07/17, Volume 158, Issue 2, p.412-21, (2014) Read More / View Supplemental Materials
Abstract
Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC.Wong, KK, Tchaicha JH, Akbay EA, Altabef A., Mikse OR, Kikuchi E., Rhee K., Liao RG, Bronson RT, Sholl LM, Meyerson M., and Hammerman PS Cancer research, 2014/07/17, (2014) Read More / View Supplemental Materials
Abstract
Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging.Hung, V., Zou P., Rhee HW, Udeshi ND, Cracan V., Svinkina T., Carr SA, Mootha VK, and Ting AY Molecular cell, 2014/07/17, Volume 55, Issue 2, p.332-41, (2014) Read More / View Supplemental Materials
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The genetic architecture of pediatric cognitive abilities in the Philadelphia Neurodevelopmental Cohort.Robinson, EB, Kirby A., Ruparel K., Yang J., McGrath L., Anttila V., Neale BM, Merikangas K., Lehner T., Sleiman PM, Daly M. J., Gur R., Gur R., and Hakonarson H. Molecular psychiatry, 2014/07/15, (2014) Read More / View Supplemental Materials
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Genetic variants in the complement system predisposing to age-related macular degeneration: A review.Schramm, EC, Clark SJ, Triebwasser MP, Raychaudhuri S., Seddon JM, and Atkinson JP Molecular immunology, 2014/07/15, (2014) Read More / View Supplemental Materials
Abstract
Imputation and subset based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.Wang, Z., Zhu B., Zhang M., Parikh H., Jia J., Chung CC, Sampson JN, Hoskins JW, Hutchinson A., Burdette L., Ibrahim A., Hautman C., Raj PS, Abnet CC, Adjei AA, Ahlbom A., Albanes D., Allen NE, Ambrosone CB, Aldrich M., et al. Human molecular genetics, 2014/07/15, (2014) Read More / View Supplemental Materials
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Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans.Du, M., Auer PL, Jiao S., Haessler J., Altshuler D., Boerwinkle E., Carlson CS, Carty CL, Chen YD, Curtis K., Franceschini N., Hsu L., Jackson R., Lange LA, Lettre G., Monda KL, and National Heart, Lung Blood Institute(NHLBI) GO Exome Sequencing Project, Nickerson DA, Reiner AP, Rich SS, et al. Human molecular genetics, 2014/07/15, (2014) Read More / View Supplemental Materials
Abstract
Effects of Weight Loss, Weight Cycling, and Weight Loss Maintenance on Diabetes Incidence and Change in Cardiometabolic Traits in the Diabetes Prevention Program.Delahanty, LM, Pan Q., Jablonski KA, Aroda VR, Watson KE, Bray GA, Kahn SE, Florez JC, Perreault L., Franks PW, and for the Diabetes Prevention Program Research Group Diabetes care, 2014/07/14, (2014) Read More / View Supplemental Materials
Abstract
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.Wawer, MJ, Li K., Gustafsdottir SM, Ljosa V., Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E., Taylor B., Grant GB, Hon CS, Duvall JR, Wilson JA, Bittker JA, Dančík V., Narayan R., Subramanian A., Winckler W., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/07/14, (2014) Read More / View Supplemental Materials
Abstract
Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.Yu, M., Bardia A., Aceto N., Bersani F., Madden MW, Donaldson MC, Desai R., Zhu H., Comaills V., Zheng Z., Wittner BS, Stojanov P., Brachtel E., Sgroi D., Kapur R., Shioda T., Ting DT, Ramaswamy S., Getz G., Iafrate AJ, et al. Science (New York, N.Y.), 2014/07/11, Volume 345, Issue 6193, p.216-20, (2014) Read More / View Supplemental Materials
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Metabolite Markers of Incident CKD Risk.Rhee, EP, and Feldman HI Clinical journal of the American Society of Nephrology : CJASN, 2014/07/10, (2014) Read More / View Supplemental Materials
Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease.Hung, CM, Calejman CM, Sanchez-Gurmaches J., Li H., Clish CB, Hettmer S., Wagers AJ, and Guertin DA Cell reports, 2014/07/10, Volume 8, Issue 1, p.256-71, (2014) Read More / View Supplemental Materials
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Analysis of a Food-Borne Fungal Pathogen Outbreak: Virulence and Genome of a Mucor circinelloides Isolate from Yogurt.Lee, SC, Billmyre RB, Li A., Carson S., Sykes SM, Huh EY, Mieczkowski P., Ko DC, Cuomo CA, and Heitman J. mBio, 2014/07/08, Volume 5, Issue 4, (2014) Read More / View Supplemental Materials
Abstract
Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.Lodato, S., Molyneaux BJ, Zuccaro E., Goff LA, Chen HH, Yuan W., Meleski A., Takahashi E., Mahony S., Rinn JL, Gifford DK, and Arlotta P. Nature neuroscience, 2014/07/06, (2014) Read More / View Supplemental Materials
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Complete Genome Sequences of Bacillus subtilis subsp. subtilis Laboratory Strains JH642 (AG174) and AG1839.Smith, JL, Goldberg JM, and Grossman AD Genome announcements, 2014/07/03, Volume 2, Issue 4, (2014) Read More / View Supplemental Materials
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Expansion of biological pathways based on evolutionary inference.Li, Y., Calvo SE, Gutman R., Liu JS, and Mootha VK Cell, 2014/07/03, Volume 158, Issue 1, p.213-25, (2014) Read More / View Supplemental Materials
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How far can mice carry autism research?Hyman, SE Cell, 2014/07/03, Volume 158, Issue 1, p.13-4, (2014) Read More / View Supplemental Materials
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IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α.Kong, X., Banks A., Liu T., Kazak L., Rao RR, Cohen P., Wang X., Yu S., Lo JC, Tseng YH, Cypess AM, Xue R., Kleiner S., Kang S., Spiegelman BM, and Rosen ED Cell, 2014/07/03, Volume 158, Issue 1, p.69-83, (2014) Read More / View Supplemental Materials
Abstract
Loss-of-function mutations in APOC3, triglycerides, and coronary disease.and TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung Blood Institute, Crosby J., Peloso GM, Auer PL, Crosslin DR, Stitziel NO, Lange LA, Lu Y., Tang ZZ, Zhang H., Hindy G., Masca N., Stirrups K., Kanoni S., Do R., Jun G., Hu Y., Kang HM, Xue C., Goel A., et al. The New England journal of medicine, 2014/07/03, Volume 371, Issue 1, p.22-31, (2014) Read More / View Supplemental Materials
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Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing.Veres, A., Gosis BS, Ding Q., Collins R., Ragavendran A., Brand H., Erdin S., Talkowski ME, and Musunuru K. Cell stem cell, 2014/07/03, Volume 15, Issue 1, p.27-30, (2014) Read More / View Supplemental Materials
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Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.Saha, SK, Parachoniak CA, Ghanta KS, Fitamant J., Ross KN, Najem MS, Gurumurthy S., Akbay EA, Sia D., Cornella H., Miltiadous O., Walesky C., Deshpande V., Zhu AX, Hezel AF, Yen KE, Straley KS, Travins J., Popovici-Muller J., Gliser C., et al. Nature, 2014/07/02, (2014) Read More / View Supplemental Materials
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Assessing the clinical utility of cancer genomic and proteomic data across tumor types.Yuan, Y., Van Allen EM, Omberg L., Wagle N., Amin-Mansour A., Sokolov A., Byers LA, Xu Y., Hess KR, Diao L., Han L., Huang X., Lawrence MS, Weinstein J. N., Stuart JM, Mills GB, Garraway LA, Margolin AA, Getz G., and Liang H. Nature biotechnology, 2014/07/01, Volume 32, Issue 7, p.644-52, (2014) Read More / View Supplemental Materials
Abstract
Copy number variation in schizophrenia in Sweden.Szatkiewicz, JP, O'Dushlaine C., Chen G., Chambert K., Moran JL, Neale BM, Fromer M., Ruderfer D., Akterin S., Bergen SE, Kähler A., Magnusson PK, Kim Y., Crowley JJ, Rees E., Kirov G., O'Donovan MC, Owen MJ, Walters J., Scolnick E., et al. Molecular psychiatry, 2014/07/01, Volume 19, Issue 7, p.762-73, (2014) Read More / View Supplemental Materials
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Defining success in graduate school.Bell, SM, Blumstein J., Brose K., Carroll A., Chang J., Charles J., Haswell ES, Michelitsch M., Owens JC, Patil CK, Smith R., Tupy J., Walsh E., and Ware T. Molecular biology of the cell, 2014/07/01, Volume 25, Issue 13, p.1942-4, (2014) Read More / View Supplemental Materials
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population.Lim, ET, Würtz P., Havulinna AS, Palta P., Tukiainen T., Rehnström K., Esko T., Mägi R., Inouye M., Lappalainen T., Chan Y., Salem RM, Lek M., Flannick J., Sim X., Manning A., Ladenvall C., Bumpstead S., Hämäläinen E., Aalto K., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004494, (2014) Read More / View Supplemental Materials
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Diverse patterns of genomic targeting by transcriptional regulators in Drosophila melanogaster.Slattery, M., Ma L., Spokony RF, Arthur RK, Kheradpour P., Kundaje A., Nègre N., Crofts A., Ptashkin R., Zieba J., Ostapenko A., Suchy S., Victorsen A., Jameel N., Grundstad AJ, Gao W., Moran JR, Rehm EJ, Grossman RL, Kellis M., et al. Genome research, 2014/07/01, Volume 24, Issue 7, p.1224-35, (2014) Read More / View Supplemental Materials
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Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations.Wik, E., Trovik J., Kusonmano K., Birkeland E., Raeder MB, Pashtan I., Hoivik EA, Krakstad C., Werner HM, Holst F., Mjøs S., Halle MK, Mannelqvist M., Mauland KK, Oyan AM, Stefansson IM, Petersen K., Simon R., Cherniack AD, Meyerson M., et al. Gynecologic oncology, 2014/07/01, (2014) Read More / View Supplemental Materials
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Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.Tang, Y., Gholamin S., Schubert S., Willardson MI, Lee A., Bandopadhayay P., Bergthold G., Masoud S., Nguyen B., Vue N., Balansay B., Yu F., Oh S., Woo P., Chen S., Ponnuswami A., Monje M., Atwood SX, Whitson RJ, Mitra S., et al. Nature medicine, 2014/07/01, Volume 20, Issue 7, p.732-740, (2014) Read More / View Supplemental Materials
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Evolving Understanding of the CLL Genome.Gruber, M., and Wu CJ Seminars in hematology, 2014/07/01, Volume 51, Issue 3, p.177-87, (2014) Read More / View Supplemental Materials
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Fast and accurate imputation of summary statistics enhances evidence of functional enrichment.Pasaniuc, B., Zaitlen N., Shi H., Bhatia G., Gusev A., Pickrell J., Hirschhorn J., Strachan DP, Patterson N., and Price AL Bioinformatics (Oxford, England), 2014/07/01, (2014) Read More / View Supplemental Materials
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Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.Mäkinen, VP, Civelek M., Meng Q., Zhang B., Zhu J., Levian C., Huan T., Segrè AV, Ghosh S., Vivar J., Nikpay M., Stewart AF, Nelson CP, Willenborg C., Erdmann J., Blakenberg S., O'Donnell CJ, März W., Laaksonen R., Epstein SE, et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004502, (2014) Read More / View Supplemental Materials
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Mitosis gives a brief window of opportunity for a change in gene transcription.Halley-Stott, RP, Jullien J., Pasque V., and Gurdon J. PLoS biology, 2014/07/01, Volume 12, Issue 7, p.e1001914, (2014) Read More / View Supplemental Materials
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Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index.Hoggart, CJ, Venturini G., Mangino M., Gomez F., Ascari G., Zhao JH, Teumer A., Winkler TW, Tšernikova N., Luan J., Mihailov E., Ehret GB, Zhang W., Lamparter D., Esko T., Macé A., Rüeger S., Bochud PY, Barcella M., Dauvilliers Y., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004508, (2014) Read More / View Supplemental Materials
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A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach.Traylor, M., Mäkelä KM, Kilarski LL, Holliday EG, Devan WJ, Nalls MA, Wiggins KL, Zhao W., Cheng YC, Achterberg S., Malik R., Sudlow C., Bevan S., Raitoharju E., METASTROKE, International Stroke Genetics Consortium Wellcome Trust Case Consortium(WTCCC2) 2, Oksala N., Thijs V., Lemmens R., Lindgren A., Slowik A., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004469, (2014) Read More / View Supplemental Materials
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Preparation of Single-Cell RNA-Seq Libraries for Next Generation Sequencing.Trombetta, JJ, Gennert D., Lu D., Satija R., Shalek AK, and Regev A. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.], 2014/07/01, Volume 107, p.4.22.1-4.22.17, (2014) Read More / View Supplemental Materials
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Soft skills: an important asset acquired from organizing regional student group activities.de Ridder, J., Meysman P., Oluwagbemi O., and Abeel T. PLoS computational biology, 2014/07/01, Volume 10, Issue 7, p.e1003708, (2014) Read More / View Supplemental Materials
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SPSB1 May Have MET Its Match during Breast Cancer Recurrence.Qin, Y., and McAllister SS Cancer discovery, 2014/07/01, Volume 4, Issue 7, p.760-1, (2014) Read More / View Supplemental Materials
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Genome Sequencing of Multiple Primary Tumors Reveals a Novel PALB2 Variant.Schrader, KA, Stratton KL, Murali R., Laitman Y., Cavallone L., Offit L., Wen YH, Thomas T., Shah S., Rau-Murthy R., Manschreck C., Salo-Mullen E., Otegbeye E., Corines M., Zhang L., Norton L., Hudis C., Klein RJ, Kauff ND, Robson M., et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014/06/30, (2014) Read More / View Supplemental Materials
CPTAC Assay Portal: a repository of targeted proteomic assays.Whiteaker, JR, Halusa GN, Hoofnagle AN, Sharma V., Maclean B., Yan P., Wrobel JA, Kennedy J., Mani D. R., Zimmerman LJ, Meyer MR, Mesri M., Rodriguez H., Clinical Proteomic Tumor Analysis Consortium(CPTAC), and Paulovich AG Nature methods, 2014/06/27, Volume 11, Issue 7, p.703-4, (2014) Read More / View Supplemental Materials
Nonhuman genetics. Genomic basis for the convergent evolution of electric organs.Gallant, JR, Traeger LL, Volkening JD, Moffett H., Chen PH, Novina CD, Phillips GN Jr, Anand R., Wells GB, Pinch M., Güth R., Unguez GA, Albert JS, Zakon HH, Samanta MP, and Sussman MR Science (New York, N.Y.), 2014/06/27, Volume 344, Issue 6191, p.1522-5, (2014) Read More / View Supplemental Materials
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Toward better understanding of artifacts in variant calling from high-coverage samples.Li, H. Bioinformatics (Oxford, England), 2014/06/27, (2014) Read More / View Supplemental Materials
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Integrated RNA and DNA sequencing improves mutation detection in low purity tumors.Wilkerson, MD, Cabanski CR, Sun W., Hoadley KA, Walter V., Mose LE, Troester MA, Hammerman PS, Parker JS, Perou CM, and Hayes DN Nucleic acids research, 2014/06/26, (2014) Read More / View Supplemental Materials
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Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.Vimaleswaran, KS, Cavadino A., Berry DJ, investigators LifeLines Cohort Study, Jorde R., Dieffenbach AK, Lu C., Alves AC, Heerspink HJ, Tikkanen E., Eriksson J., Wong A., Mangino M., Jablonski KA, Nolte IM, Houston DK, Ahluwalia TS, van der Most PJ, Pasko D., Zgaga L., et al. The lancet. Diabetes & endocrinology, 2014/06/25, (2014) Read More / View Supplemental Materials
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Mutational Signatures in Helicobacter pylori-induced Gastric Cancer: Lessons From New Sequencing Technologies.Derks, S., and Bass AJ Gastroenterology, 2014/06/25, (2014) Read More / View Supplemental Materials
Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations.Fridman, O., Goldberg A., Ronin I., Shoresh N., and Balaban NQ Nature, 2014/06/25, (2014) Read More / View Supplemental Materials
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Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5' Sites.Schwartz, S., Mumbach MR, Jovanovic M., Wang T., Maciag K., Bushkin GG, Mertins P., Ter-Ovanesyan D., Habib N., Cacchiarelli D., Sanjana NE, Freinkman E., Pacold ME, Satija R., Mikkelsen TS, Hacohen N., Zhang F., Carr SA, Lander E. S., and Regev A. Cell reports, 2014/06/25, (2014) Read More / View Supplemental Materials
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Knockdown of Malic Enzyme 2 Suppresses Lung Tumor Growth, Induces Differentiation and Impacts PI3K/AKT Signaling.Ren, JG, Seth P., Clish CB, Lorkiewicz PK, Higashi RM, Lane AN, Fan TW, and Sukhatme VP Scientific reports, 2014/06/24, Volume 4, p.5414, (2014) Read More / View Supplemental Materials
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Altered translation of GATA1 in Diamond-Blackfan anemia.Ludwig, LS, Gazda HT, Eng JC, Eichhorn SW, Thiru P., Ghazvinian R., George TI, Gotlib JR, Beggs AH, Sieff CA, Lodish HF, Lander E. S., and Sankaran VG Nature medicine, 2014/06/22, (2014) Read More / View Supplemental Materials
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Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics.Lundby, A., Rossin EJ, Steffensen AB, Acha MR, Newton-Cheh C., Pfeufer A., Lynch SN, The QT Interval International GWAS Consortium(QT-IGC), Olesen SP, Brunak S., Ellinor PT, Jukema JW, Trompet S., Ford I., Macfarlane PW, Krijthe BP, Hofman A., Uitterlinden AG, Stricker BH, Nathoe HM, et al. Nature methods, 2014/06/22, (2014) Read More / View Supplemental Materials
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Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.Heckl, D., Kowalczyk MS, Yudovich D., Belizaire R., Puram RV, McConkey ME, Thielke A., Aster J. C., Regev A., and Ebert BL Nature biotechnology, 2014/06/22, (2014) Read More / View Supplemental Materials
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Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.Arking, DE, Pulit SL, Crotti L., van der Harst P., Munroe PB, Koopmann TT, Sotoodehnia N., Rossin EJ, Morley M., Wang X., Johnson AD, Lundby A., Gudbjartsson DF, Noseworthy PA, Eijgelsheim M., Bradford Y., Tarasov KV, Dörr M., Müller-Nurasyid M., Lahtinen AM, et al. Nature genetics, 2014/06/22, (2014) Read More / View Supplemental Materials
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A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy.Kuiper, JJ, van Setten J., Ripke S., Van't Slot R., Mulder F., Missotten T., Baarsma GS, Francioli LC, Pulit SL, de Kovel CG, Ten Dam-van Loon N., den Hollander AI, Huis In Het Veld P., Hoyng CB, Cordero-Coma M., Martín J., Llorenç V., Arya B., Thomas D., Bakker SC, et al. Human molecular genetics, 2014/06/22, (2014) Read More / View Supplemental Materials
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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.Kwiatkowski, N., Zhang T., Rahl PB, Abraham BJ, Reddy J., Ficarro SB, Dastur A., Amzallag A., Ramaswamy S., Tesar B., Jenkins CE, Hannett NM, McMillin D., Sanda T., Sim T., Kim ND, Look T., Mitsiades CS, Weng AP, Brown JR, et al. Nature, 2014/06/22, (2014) Read More / View Supplemental Materials
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Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.Patel, AP, Tirosh I., Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H., Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O., Suvà ML, Regev A., and Bernstein BE Science (New York, N.Y.), 2014/06/20, Volume 344, Issue 6190, p.1396-401, (2014) Read More / View Supplemental Materials
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Functional Divergence of the MiRNA Transcriptome at the Onset of Drosophila Metamorphosis.Yeh, SD, von Grotthuss M., Gandasetiawan KA, Jayasekera S., Xia XQ, Chan C., Jayaswal V., and Ranz JM Molecular biology and evolution, 2014/06/19, (2014) Read More / View Supplemental Materials
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Inflammatory Bowel Disease as a Model for Translating the Microbiome.Huttenhower, C., Kostic AD, and Xavier RJ Immunity, 2014/06/19, Volume 40, Issue 6, p.843-854, (2014) Read More / View Supplemental Materials
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Metabolite Traits and Genetic Risk Provide Complementary Information for the Prediction of Future Type 2 Diabetes.Walford, GA, Porneala BC, Dauriz M., Vassy JL, Cheng S., Rhee EP, Wang TJ, Meigs JB, Gerszten RE, and Florez JC Diabetes care, 2014/06/19, (2014) Read More / View Supplemental Materials
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Single-cell RNA-seq reveals dynamic paracrine control of cellular variation.Shalek, AK, Satija R., Shuga J., Trombetta JJ, Gennert D., Lu D., Chen P., Gertner RS, Gaublomme JT, Yosef N., Schwartz S., Fowler B., Weaver S., Wang J., Wang X., Ding R., Raychowdhury R., Friedman N., Hacohen N., Park H., et al. Nature, 2014/06/19, Volume 509, Issue 7505, p.363-9, (2014) Read More / View Supplemental Materials
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Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo.Grgic, I., Hofmeister AF, Genovese G., Bernhardy AJ, Sun H., Maarouf OH, Bijol V., Pollak MR, and Humphreys BD Kidney international, 2014/06/18, (2014) Read More / View Supplemental Materials
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Improving accuracy of rare variant imputation with a two-step imputation approach.Kreiner-Møller, E., Medina-Gomez C., Uitterlinden AG, Rivadeneira F., and Estrada K. European journal of human genetics : EJHG, 2014/06/18, (2014) Read More / View Supplemental Materials
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Evidence of Extensive DNA Transfer between Bacteroidales Species within the Human Gut.Coyne, MJ, Zitomersky NL, McGuire AM, Earl AM, and Comstock LE mBio, 2014/06/17, Volume 5, Issue 3, (2014) Read More / View Supplemental Materials
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KRAS and YAP1 Converge to Regulate EMT and Tumor Survival.Shao, DD, Xue W., Krall EB, Bhutkar A., Piccioni F., Wang X., Schinzel AC, Sood S., Rosenbluh J., Kim JW, Zwang Y., Roberts TM, Root DE, Jacks T., and Hahn WC Cell, 2014/06/17, (2014) Read More / View Supplemental Materials
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An arp2/3 nucleated f-actin shell fragments nuclear membranes at nuclear envelope breakdown in starfish oocytes.Mori, M., Somogyi K., Kondo H., Monnier N., Falk HJ, Machado P., Bathe M., Nédélec F., and Lénárt P. Current biology : CB, 2014/06/16, Volume 24, Issue 12, p.1421-8, (2014) Read More / View Supplemental Materials
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JARID1B Is a Luminal Lineage-Driving Oncogene in Breast Cancer.Yamamoto, S., Wu Z., Russnes HG, Takagi S., Peluffo G., Vaske C., Zhao X., Moen Vollan HK, Maruyama R., Ekram MB, Sun H., Kim JH, Carver K., Zucca M., Feng J., Almendro V., Bessarabova M., Rueda OM, Nikolsky Y., Caldas C., et al. Cancer cell, 2014/06/16, Volume 25, Issue 6, p.762-77, (2014) Read More / View Supplemental Materials
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MDS Is a Stem Cell Disorder After All.Jaiswal, S., and Ebert BL Cancer cell, 2014/06/16, Volume 25, Issue 6, p.713-4, (2014) Read More / View Supplemental Materials
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Pareto-optimal phylogenetic tree reconciliation.Libeskind-Hadas, R., Wu YC, Bansal MS, and Kellis M. Bioinformatics (Oxford, England), 2014/06/15, Volume 30, Issue 12, p.i87-i95, (2014) Read More / View Supplemental Materials
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Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.Consortium, SIGMA Type Diabetes 2, Estrada K., Aukrust I., Bjørkhaug L., Burtt NP, Mercader JM, García-Ortiz H., Huerta-Chagoya A., Moreno-Macías H., Walford G., Flannick J., Williams AL, Gómez-Vázquez MJ, Fernandez-Lopez JC, Martínez-Hernández A., Centeno-Cruz F., Mendoza-Caamal E., Revilla-Monsalve C., Islas-Andrade S., Córdova EJ, et al. JAMA : the journal of the American Medical Association, 2014/06/11, Volume 311, Issue 22, p.2305-14, (2014) Read More / View Supplemental Materials
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Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes.Melnikov, A., Rogov P., Wang L., Gnirke A., and Mikkelsen TS Nucleic acids research, 2014/06/09, (2014) Read More / View Supplemental Materials
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Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences.Pugh, TJ, Yu W., Yang J., Field AL, Ambrogio L., Carter SL, Cibulskis K., Giannikopoulos P., Kiezun A., Kim J., McKenna A., Nickerson E., Getz G., Hoffher S., Messinger YH, Dehner LP, Roberts CW, Rodriguez-Galindo C., Williams GM, Rossi CT, et al. Oncogene, 2014/06/09, (2014) Read More / View Supplemental Materials
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Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells.Wang, J., Mikse O., Liao RG, Li Y., Tan L., Janne PA, Gray NS, Wong KK, and Hammerman PS Oncogene, 2014/06/09, (2014) Read More / View Supplemental Materials
Abstract
PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling.Moody, SE, Schinzel AC, Singh S., Izzo F., Strickland MR, Luo L., Thomas SR, Boehm JS, Kim SY, Wang ZC, and Hahn WC Oncogene, 2014/06/09, (2014) Read More / View Supplemental Materials
Abstract
Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types.Li, Q., Stram A., Chen C., Kar S., Gayther S., Pharoah P., Haiman C., Stranger B., Kraft P., and Freedman ML Human molecular genetics, 2014/06/06, (2014) Read More / View Supplemental Materials
Abstract
LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.Duan, Q., Flynn C., Niepel M., Hafner M., Muhlich JL, Fernandez NF, Rouillard AD, Tan CM, Chen EY, Golub T. R., Sorger PK, Subramanian A., and Ma'ayan A. Nucleic acids research, 2014/06/06, (2014) Read More / View Supplemental Materials
Abstract
Selection of unique Escherichia coli clones by random amplified polymorphic DNA (RAPD): Evaluation by whole genome sequencing.Nielsen, KL, Godfrey PA, Stegger M., Andersen PS, Feldgarden M., and Frimodt-Møller N. Journal of microbiological methods, 2014/06/06, (2014) Read More / View Supplemental Materials
Abstract
Development and Applications of CRISPR-Cas9 for Genome Engineering.Hsu, PD, Lander E. S., and Zhang F. Cell, 2014/06/05, Volume 157, Issue 6, p.1262-1278, (2014) Read More / View Supplemental Materials
Abstract
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.Kiskinis, E., Sandoe J., Williams LA, Boulting GL, Moccia R., Wainger BJ, Han S., Peng T., Thams S., Mikkilineni S., Mellin C., Merkle FT, Davis-Dusenbery BN, Ziller M., Oakley D., Ichida J., Di Costanzo S., Atwater N., Maeder ML, Goodwin MJ, et al. Cell stem cell, 2014/06/05, Volume 14, Issue 6, p.781-95, (2014) Read More / View Supplemental Materials
Abstract
Transcriptional consequences of 16p11.2 deletion and duplication in mouse cortex and multiplex autism families.Blumenthal, I., Ragavendran A., Erdin S., Klei L., Sugathan A., Guide JR, Manavalan P., Zhou JQ, Wheeler VC, Levin JZ, Ernst C., Roeder K., Devlin B., Gusella JF, and Talkowski ME American journal of human genetics, 2014/06/05, Volume 94, Issue 6, p.870-83, (2014) Read More / View Supplemental Materials
Abstract
Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'Deelen, P., Menelaou A., van Leeuwen EM, Kanterakis A., van Dijk F., Medina-Gomez C., Francioli LC, Hottenga JJ, Karssen LC, Estrada K., Kreiner-Møller E., Rivadeneira F., van Setten J., Gutierrez-Achury J., Westra HJ, Franke L., van Enckevort D., Dijkstra M., Byelas H., van Duijn CM, et al. European journal of human genetics : EJHG, 2014/06/04, (2014) Read More / View Supplemental Materials
Abstract
MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets.Strazisar, M., Cammaerts S., van der Ven K., Forero DA, Lenaerts AS, Nordin A., Almeida-Souza L., Genovese G., Timmerman V., Liekens A., De Rijk P., Adolfsson R., Callaerts P., and Del-Favero J. Molecular psychiatry, 2014/06/03, (2014) Read More / View Supplemental Materials
Abstract
SMASH: A Benchmarking Toolkit for Human Genome Variant Calling.Talwalkar, A., Liptrap J., Newcomb J., Hartl C., Terhorst J., Curtis K., Bresler M., Song YS, Jordan MI, and Patterson D. Bioinformatics (Oxford, England), 2014/06/03, (2014) Read More / View Supplemental Materials
Abstract
Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.Rajasagi, M., Shukla SA, Fritsch EF, Keskin DB, Deluca D., Carmona E., Zhang W., Sougnez C., Cibulskis K., Sidney J., Stevenson K., Ritz J., Neuberg D., Brusic V., Gabriel S., Lander E. S., Getz G., Hacohen N., and Wu CJ Blood, 2014/06/02, (2014) Read More / View Supplemental Materials
Abstract
Genome-scale neurogenetics: methodology and meaning.McCarroll, SA, Feng G., and Hyman SE Nature neuroscience, 2014/06/01, Volume 17, Issue 6, p.756-63, (2014) Read More / View Supplemental Materials
Abstract
Glycogen synthase kinase-3β inhibition ameliorates cardiac parasympathetic dysfunction in type 1 diabetic akita mice.Zhang, Y., Welzig CM, Picard KL, Du C., Wang B., Pan JQ, Kyriakis JM, Aronovitz MJ, Claycomb WC, Blanton RM, Park HJ, and Galper JB Diabetes, 2014/06/01, Volume 63, Issue 6, p.2097-113, (2014) Read More / View Supplemental Materials
Abstract
HLA-Binding Properties of Tumor Neoepitopes in Humans.Fritsch, EF, Rajasagi M., Ott PA, Brusic V., Hacohen N., and Wu CJ Cancer immunology research, 2014/06/01, Volume 2, Issue 6, p.522-9, (2014) Read More / View Supplemental Materials
Abstract
Integrated Pathway-Based Approach Identifies Association between Genomic Regions at CTCF and CACNB2 and Schizophrenia.Juraeva, D., Haenisch B., Zapatka M., Frank J., GROUP Investigators, group PSYCH-GEMS SCZ working, Witt SH, Mühleisen TW, Treutlein J., Strohmaier J., Meier S., Degenhardt F., Giegling I., Ripke S., Leber M., Lange C., Schulze TG, Mössner R., Nenadic I., Sauer H., et al. PLoS genetics, 2014/06/01, Volume 10, Issue 6, p.e1004345, (2014) Read More / View Supplemental Materials
Abstract
Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells.Hu, X., Im HK, Raj T., Brennan PJ, Trynka G., Teslovich N., Slowikowski K., Chen WM, Onengut S., Baecher-Allan C., De Jager PL, Rich SS, Stranger BE, Brenner MB, and Raychaudhuri S. PLoS genetics, 2014/06/01, Volume 10, Issue 6, p.e1004404, (2014) Read More / View Supplemental Materials
Abstract
Ubiquitin-Mediated Response to Microsporidia and Virus Infection in C. elegans.Bakowski, MA, Desjardins CA, Smelkinson MG, Dunbar TA, Lopez-Moyado IF, Rifkin SA, Cuomo CA, and Troemel ER PLoS pathogens, 2014/06/01, Volume 10, Issue 6, p.e1004200, (2014) Read More / View Supplemental Materials
Abstract
Vaccines and Melanoma.Ott, PA, Fritsch EF, Wu CJ, and Dranoff G. Hematology/oncology clinics of North America, 2014/06/01, Volume 28, Issue 3, p.559-569, (2014) Read More / View Supplemental Materials
Abstract
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine.Van Allen, EM, Wagle N., Stojanov P., Perrin DL, Cibulskis K., Marlow S., Jane-Valbuena J., Friedrich DC, Kryukov G., Carter SL, McKenna A., Sivachenko A., Rosenberg M., Kiezun A., Voet D., Lawrence M., Lichtenstein LT, Gentry JG, Huang FW, Fostel J., et al. Nature medicine, 2014/06/01, Volume 20, Issue 6, p.682-8, (2014) Read More / View Supplemental Materials
Abstract
Whole-genome analyses of whole-brain data: working within an expanded search space.Medland, SE, Jahanshad N., Neale BM, and Thompson PM Nature neuroscience, 2014/06/01, Volume 17, Issue 6, p.791-800, (2014) Read More / View Supplemental Materials
Abstract
Protein-protein interactions and genetic diseases: The Interactome.Lage, K. Biochimica et biophysica acta, 2014/05/31, (2014) Read More / View Supplemental Materials
Abstract
The dog as a genetic model for immunoglobulin A (IgA) deficiency: Identification of several breeds with low serum IgA concentrations.Olsson, M., Frankowiack M., Tengvall K., Roosje P., Fall T., Ivansson E., Bergvall K., Hansson-Hamlin H., Sundberg K., Hedhammar A., Lindblad-Toh K., and Hammarström L. Veterinary immunology and immunopathology, 2014/05/27, (2014) Read More / View Supplemental Materials
Abstract
Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.Lee, Y., Dominy JE, Choi YJ, Jurczak M., Tolliday N., Camporez JP, Chim H., Lim JH, Ruan HB, Yang X., Vazquez F., Sicinski P., Shulman GI, and Puigserver P. Nature, 2014/05/25, (2014) Read More / View Supplemental Materials
Abstract
Genome Sequence of the Pathogenic Fungus Sporothrix schenckii (ATCC 58251).Cuomo, CA, Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A., Goldberg J., Young S., Zeng Q., and Birren BW Genome announcements, 2014/05/22, Volume 2, Issue 3, (2014) Read More / View Supplemental Materials
Abstract
FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder.Guancial, EA, Werner L., Bellmunt J., Bamias A., Choueiri TK, Ross R., Schutz FA, Park RS, O'Brien RJ, Hirsch MS, Barletta JA, Berman DM, Lis R., Loda M., Stack EC, Garraway LA, Riester M., Michor F., Kantoff PW, and Rosenberg JE Cancer medicine, 2014/05/21, (2014) Read More / View Supplemental Materials
Abstract
Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine.Wurst, JM, Drake EJ, Theriault JR, Jewett IT, VerPlank L., Perez JR, Dandapani S., Palmer M., Moskowitz SM, Schreiber SL, Munoz B., and Gulick AM ACS chemical biology, 2014/05/21, (2014) Read More / View Supplemental Materials
Abstract
PP2A-Mediated Regulation of Ras Signaling in G2 Is Essential for Stable Quiescence and Normal G1 Length.Naetar, N., Soundarapandian V., Litovchick L., Goguen KL, Sablina AA, Bowman-Colin C., Sicinski P., Hahn WC, DeCaprio JA, and Livingston DM Molecular cell, 2014/05/21, (2014) Read More / View Supplemental Materials
Abstract
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