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2015
Modeling malaria genomics reveals transmission decline and rebound in Senegal.Daniels, RF, Schaffner SF, Wenger EA, Proctor JL, Chang HH, Wong W., Baro N., Ndiaye D., Fall FB, Ndiop M., Ba M., Milner DA Jr, Taylor TE, Neafsey DE, Volkman SK, Eckhoff PA, Hartl DL, and Wirth DF Proceedings of the National Academy of Sciences of the United States of America, 2015/05/04, (2015) Read More / View Supplemental Materials
Abstract
Accounting for experimental noise reveals that mRNA levels, amplified by post-transcriptional processes, largely determine steady-state protein levels in yeast.Csárdi, G., Franks A., Choi DS, Airoldi EM, and Drummond DA PLoS genetics, 2015/05/01, Volume 11, Issue 5, p.e1005206, (2015) Read More / View Supplemental Materials
Abstract
Cell Specific eQTL Analysis without Sorting Cells.Westra, HJ, Arends D., Esko T., Peters MJ, Schurmann C., Schramm K., Kettunen J., Yaghootkar H., Fairfax BP, Andiappan AK, Li Y., Fu J., Karjalainen J., Platteel M., Visschedijk M., Weersma RK, Kasela S., Milani L., Tserel L., Peterson P., et al. PLoS genetics, 2015/05/01, Volume 11, Issue 5, p.e1005223, (2015) Read More / View Supplemental Materials
Abstract
CRISPR germline engineering--the community speaks.Bosley, KS, Botchan M., Bredenoord AL, Carroll D., Charo RA, Charpentier E., Cohen R., Corn J., Doudna J., Feng G., Greely HT, Isasi R., Ji W., Kim JS, Knoppers B., Lanphier E., Li J., Lovell-Badge R., Martin GS, Moreno J., et al. Nature biotechnology, 2015/05/01, Volume 33, Issue 5, p.478-86, (2015) Read More / View Supplemental Materials
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.Bavamian, S., Mellios N., Lalonde J., Fass DM, Wang J., Sheridan SD, Madison JM, Zhou F., Rueckert EH, Barker D., Perlis RH, Sur M., and Haggarty SJ Molecular psychiatry, 2015/05/01, Volume 20, Issue 5, p.573-84, (2015) Read More / View Supplemental Materials
Abstract
Entropic Description of Gas Hydrate Ice-Liquid Equilibrium via Enhanced Sampling of Coexisting Phases.Małolepsza, E., Kim J., and Keyes T. Physical review letters, 2015/05/01, Volume 114, Issue 17, p.170601, (2015) Read More / View Supplemental Materials
Abstract
Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.Van Allen, EM, Lui VW, Egloff AM, Goetz EM, Li H., Johnson JT, Duvvuri U., Bauman JE, Stransky N., Zeng Y., Gilbert BR, Pendleton KP, Wang L., Chiosea S., Sougnez C., Wagle N., Zhang F., Du Y., Close D., Johnston PA, et al. JAMA oncology, 2015/05/01, Volume 1, Issue 2, p.238-44, (2015) Read More / View Supplemental Materials
Abstract
High-throughput functional genomics using CRISPR-Cas9.Shalem, O., Sanjana NE, and Zhang F. Nature reviews. Genetics, 2015/05/01, Volume 16, Issue 5, p.299-311, (2015) Read More / View Supplemental Materials
Abstract
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.Etchegaray, JP, Chavez L., Huang Y., Ross KN, Choi J., Martinez-Pastor B., Walsh RM, Sommer CA, Lienhard M., Gladden A., Kugel S., Silberman DM, Ramaswamy S., Mostoslavsky G., Hochedlinger K., Goren A., Rao A., and Mostoslavsky R. Nature cell biology, 2015/05/01, Volume 17, Issue 5, p.545-57, (2015) Read More / View Supplemental Materials
Abstract
Noncoding RNAs connect genetic risk factors to the neurodevelopmental basis of bipolar disorder.Bavamian, S., Mellios N., Lalonde J., Fass DM, Wang J., Sheridan SD, Madison JM, Zhou F., Rueckert EH, Barker D., Perlis RH, Sur M., and Haggarty SJ Molecular psychiatry, 2015/05/01, Volume 20, Issue 5, p.548, (2015) Read More / View Supplemental Materials
Spatial reconstruction of single-cell gene expression data.Satija, R., Farrell JA, Gennert D., Schier AF, and Regev A. Nature biotechnology, 2015/05/01, Volume 33, Issue 5, p.495-502, (2015) Read More / View Supplemental Materials
Abstract
Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models.Karr, JR, Williams AH, Zucker JD, Raue A., Steiert B., Timmer J., Kreutz C., DREAM8 Parameter Estimation Challenge Consortium, Wilkinson S., Allgood BA, Bot BM, Hoff BR, Kellen MR, Covert MW, Stolovitzky GA, and Meyer P. PLoS computational biology, 2015/05/01, Volume 11, Issue 5, p.e1004096, (2015) Read More / View Supplemental Materials
Abstract
APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL.Gesierich, B., Opherk C., Rosand J., Gonik M., Malik R., Jouvent E., Hervé D., Adib-Samii P., Bevan S., Pianese L., Silvestri S., Dotti MT, De Stefano N., van der Grond J., Boon EM, Pescini F., Rost N., Pantoni L., Lesnik Oberstein SA, Federico A., et al. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015/04/29, (2015) Read More / View Supplemental Materials
Abstract
Comparing Platforms for Messenger RNA Expression Profiling of Archival Formalin-Fixed, Paraffin-Embedded Tissues.Tyekucheva, S., Martin NE, Stack EC, Wei W., Vathipadiekal V., Waldron L., Fiorentino M., Lis RT, Stampfer MJ, Loda M., Parmigiani G., Mucci LA, and Birrer M. The Journal of molecular diagnostics : JMD, 2015/04/29, (2015) Read More / View Supplemental Materials
Abstract
Efficient CRISPR-Cas9-Mediated Generation of Knockin Human Pluripotent Stem Cells Lacking Undesired Mutations at the Targeted Locus.Merkle, FT, Neuhausser WM, Santos D., Valen E., Gagnon JA, Maas K., Sandoe J., Schier AF, and Eggan K. Cell reports, 2015/04/29, (2015) Read More / View Supplemental Materials
Abstract
Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.Viatte, S., Plant D., Han B., Fu B., Yarwood A., Thomson W., Symmons DP, Worthington J., Young A., Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Raychaudhuri S., and Barton A. JAMA, 2015/04/28, Volume 313, Issue 16, p.1645-56, (2015) Read More / View Supplemental Materials
Abstract
CDC20 maintains tumor initiating cells.Xie, Q., Wu Q., Mack SC, Yang K., Kim L., Hubert CG, Flavahan WA, Chu C., Bao S., and Rich JN Oncotarget, 2015/04/28, (2015) Read More / View Supplemental Materials
Abstract
A Multivariate Computational Method to Analyze High-Content RNAi Screening Data.Rameseder, J., Krismer K., Dayma Y., Ehrenberger T., Hwang MK, Airoldi EM, Floyd SR, and Yaffe MB Journal of biomolecular screening, 2015/04/27, (2015) Read More / View Supplemental Materials
Abstract
Sequencing and beyond: integrating molecular 'omics' for microbial community profiling.Franzosa, EA, Hsu T., Sirota-Madi A., Shafquat A., Abu-Ali G., Morgan XC, and Huttenhower C. Nature reviews. Microbiology, 2015/04/27, (2015) Read More / View Supplemental Materials
Abstract
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3.McHugh, CA, Chen CK, Chow A., Surka CF, Tran C., McDonel P., Pandya-Jones A., Blanco M., Burghard C., Moradian A., Sweredoski MJ, Shishkin AA, Su J., Lander E. S., Hess S., Plath K., and Guttman M. Nature, 2015/04/27, (2015) Read More / View Supplemental Materials
Abstract
A depauperate immune repertoire precedes evolution of sociality in bees.Barribeau, SM, Sadd BM, du Plessis L., Brown MJ, Buechel SD, Cappelle K., Carolan JC, Christiaens O., Colgan TJ, Erler S., Evans J., Helbing S., Karaus E., Lattorff HM, Marxer M., Meeus I., Näpflin K., Niu J., Schmid-Hempel R., Smagghe G., et al. Genome biology, 2015/04/24, Volume 16, Issue 1, p.83, (2015) Read More / View Supplemental Materials
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The genomes of two key bumblebee species with primitive eusocial organization.Sadd, BM, Barribeau SM, Bloch G., de Graaf DC, Dearden P., Elsik CG, Gadau J., Grimmelikhuijzen CJ, Hasselmann M., Lozier JD, Robertson HM, Smagghe G., Stolle E., Van Vaerenbergh M., Waterhouse RM, Bornberg-Bauer E., Klasberg S., Bennett AK, Câmara F., Guigó R., et al. Genome biology, 2015/04/24, Volume 16, Issue 1, p.76, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.Yin, X., Low HQ, Wang L., Li Y., Ellinghaus E., Han J., Estivill X., Sun L., Zuo X., Shen C., Zhu C., Zhang A., Sanchez F., Padyukov L., Catanese JJ, Krueger GG, Duffin KC, Mucha S., Weichenthal M., Weidinger S., et al. Nature communications, 2015/04/23, Volume 6, p.6916, (2015) Read More / View Supplemental Materials
Abstract
Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism.Olson, DE, Sleiman SF, Bourassa MW, Wagner FF, Gale JP, Zhang YL, Ratan RR, and Holson EB Chemistry & biology, 2015/04/23, Volume 22, Issue 4, p.439-45, (2015) Read More / View Supplemental Materials
Abstract
Long non-coding RNA discovery across the genus anopheles reveals conserved secondary structures within and beyond the Gambiae complex.Jenkins, AM, Waterhouse RM, and Muskavitch MA BMC genomics, 2015/04/23, Volume 16, Issue 1, p.337, (2015) Read More / View Supplemental Materials
Abstract
The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic stress disorder enters the age of large-scale genomic collaboration.Logue, MW, Amstadter AB, Baker DG, Duncan L., Koenen KC, Liberzon I., Miller MW, Morey RA, Nievergelt CM, Ressler KJ, Smith AK, Smoller JW, Stein MB, Sumner JA, and Uddin M. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015/04/23, (2015) Read More / View Supplemental Materials
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Toward the rational design of carbapenem uptake in Pseudomonas aeruginosa.Isabella, VM, Campbell AJ, Manchester J., Sylvester M., Nayar AS, Ferguson KE, Tommasi R., and Miller AA Chemistry & biology, 2015/04/23, Volume 22, Issue 4, p.535-47, (2015) Read More / View Supplemental Materials
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Widespread macromolecular interaction perturbations in human genetic disorders.Sahni, N., Yi S., Taipale M., Fuxman Bass JI, Coulombe-Huntington J., Yang F., Peng J., Weile J., Karras GI, Wang Y., Kovács IA, Kamburov A., Krykbaeva I., Lam MH, Tucker G., Khurana V., Sharma A., Liu YY, Yachie N., Zhong Q., et al. Cell, 2015/04/23, Volume 161, Issue 3, p.647-60, (2015) Read More / View Supplemental Materials
Abstract
Complete Genomes Reveal Signatures of Demographic and Genetic Declines in the Woolly Mammoth.Palkopoulou, E., Mallick S., Skoglund P., Enk J., Rohland N., Li H., Omrak A., Vartanyan S., Poinar H., Götherström A., Reich D., and Dalén L. Current biology : CB, 2015/04/21, (2015) Read More / View Supplemental Materials
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Developing Medicines That Mimic the Natural Successes of the Human Genome: Lessons From NPC1L1, HMGCR, PCSK9, APOC3, and CETP.Kathiresan, S. Journal of the American College of Cardiology, 2015/04/21, Volume 65, Issue 15, p.1562-6, (2015) Read More / View Supplemental Materials
Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation.Rotem, A., Janzer A., Izar B., Ji Z., Doench JG, Garraway LA, and Struhl K. Proceedings of the National Academy of Sciences of the United States of America, 2015/04/20, (2015) Read More / View Supplemental Materials
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DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader.Rock, JM, Lang UF, Chase MR, Ford CB, Gerrick ER, Gawande R., Coscolla M., Gagneux S., Fortune SM, and Lamers MH Nature genetics, 2015/04/20, (2015) Read More / View Supplemental Materials
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Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.Gutierrez-Achury, J., Zhernakova A., Pulit SL, Trynka G., Hunt KA, Romanos J., Raychaudhuri S., van Heel DA, Wijmenga C., and de Bakker PI Nature genetics, 2015/04/20, (2015) Read More / View Supplemental Materials
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Calibrating genomic and allelic coverage bias in single-cell sequencing.Zhang, CZ, Adalsteinsson VA, Francis J., Cornils H., Jung J., Maire C., Ligon KL, Meyerson M., and Love JC Nature communications, 2015/04/16, Volume 6, p.6822, (2015) Read More / View Supplemental Materials
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Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage.Younger, ST, Kenzelmann-Broz D., Jung H., Attardi LD, and Rinn JL Nucleic acids research, 2015/04/16, (2015) Read More / View Supplemental Materials
Abstract
Pugh et al. reply.Pugh, TJ, Banerji S., and Meyerson M. Nature, 2015/04/16, Volume 520, Issue 7547, p.E12-4, (2015) Read More / View Supplemental Materials
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.Kim, D., Fiske BP, Birsoy K., Freinkman E., Kami K., Possemato RL, Chudnovsky Y., Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M., Ramkissoon SH, Ligon KL, Kang SW, Snuderl M., Vander Heiden MG, and Sabatini DM Nature, 2015/04/16, Volume 520, Issue 7547, p.363-7, (2015) Read More / View Supplemental Materials
Abstract
Live Cell Multi-Photon Fluorescence Correlation Spectroscopy with an Improved Large Stokes Shift Fluorescent Protein.Guan, Y., Meurer M., Raghavan S., Rebane A., Lindquist JR, Santos S., Kats I., Davidson MW, Mazitschek R., Hughes TE, Drobizhev M., Knop M., and Shah JV Molecular biology of the cell, 2015/04/15, (2015) Read More / View Supplemental Materials
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Cases of Ebola virus disease predicted to rise from hundreds to thousands per week unless control measures improve.Andersen, KG Evidence-based nursing, 2015/04/14, (2015) Read More / View Supplemental Materials
Mixed Model with Correction for Case-Control Ascertainment Increases Association Power.Hayeck, TJ, Zaitlen NA, Loh PR, Vilhjalmsson B., Pollack S., Gusev A., Yang J., Chen GB, Goddard ME, Visscher PM, Patterson N., and Price AL American journal of human genetics, 2015/04/14, (2015) Read More / View Supplemental Materials
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Distinct metabolomic signatures are associated with longevity in humans.Cheng, S., Larson MG, McCabe EL, Murabito JM, Rhee EP, Ho JE, Jacques PF, Ghorbani A., Magnusson M., Souza AL, Deik AA, Pierce KA, Bullock K., O'Donnell CJ, Melander O., Clish CB, Vasan RS, Gerszten RE, and Wang TJ Nature communications, 2015/04/13, Volume 6, p.6791, (2015) Read More / View Supplemental Materials
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Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.Dockendorff, C., Faloon PW, Germain A., Yu M., Youngsaye W., Nag PP, Bennion M., Penman M., Nieland TJ, Dandapani S., Perez JR, Munoz B., Palmer MA, Schreiber SL, and Krieger M. Bioorganic & medicinal chemistry letters, 2015/04/11, (2015) Read More / View Supplemental Materials
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Genome-wide association studies of late-onset cardiovascular disease.Gustav Smith, J., and Newton-Cheh C. Journal of molecular and cellular cardiology, 2015/04/11, (2015) Read More / View Supplemental Materials
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DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors.Bambury, RM, Bhatt AS, Riester M., Pedamallu CS, Duke F., Bellmunt J., Stack EC, Werner L., Park R., Iyer G., Loda M., Kantoff PW, Michor F., Meyerson M., and Rosenberg JE BMC cancer, 2015/04/09, Volume 15, p.242, (2015) Read More / View Supplemental Materials
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In vivo genome editing using Staphylococcus aureus Cas9.Ran, FA, Cong L., Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B., Shalem O., Wu X., Makarova KS, Koonin EV, Sharp PA, and Zhang F. Nature, 2015/04/09, Volume 520, Issue 7546, p.186-91, (2015) Read More / View Supplemental Materials
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Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease.Morgan, XC, Kabakchiev B., Waldron L., Tyler AD, Tickle TL, Milgrom R., Stempak JM, Gevers D., Xavier RJ, Silverberg MS, and Huttenhower C. Genome biology, 2015/04/08, Volume 16, Issue 1, p.67, (2015) Read More / View Supplemental Materials
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Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification.Kim, J., Xiao H., Koh J., Wang Y., Bonanno JB, Thomas K., Babbitt PC, Brown S., Lee YS, and Almo SC Nucleic acids research, 2015/04/08, (2015) Read More / View Supplemental Materials
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Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development.Chan, Y., Salem RM, Hsu YH, McMahon G., Pers TH, Vedantam S., Esko T., Guo MH, Lim ET, GIANT Consortium, Franke L., Smith GD, Strachan DP, and Hirschhorn JN American journal of human genetics, 2015/04/08, (2015) Read More / View Supplemental Materials
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Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination.Nakayama, T., Al-Maawali A., El-Quessny M., Rajab A., Khalil S., Stoler JM, Tan WH, Nasir R., Schmitz-Abe K., Hill RS, Partlow JN, Al-Saffar M., Servattalab S., LaCoursiere CM, Tambunan DE, Coulter ME, Elhosary PC, Gorski G., Barkovich AJ, Markianos K., et al. American journal of human genetics, 2015/04/08, (2015) Read More / View Supplemental Materials
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Criteria for biological reproducibility: What does "n" mean?Naegle, K., Gough NR, and Yaffe MB Science signaling, 2015/04/07, Volume 8, Issue 371, p.fs7, (2015) Read More / View Supplemental Materials
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Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis.Miao, J., Ling AV, Manthena PV, Gearing ME, Graham MJ, Crooke RM, Croce KJ, Esquejo RM, Clish CB, Morbid Obesity Study Group, Vicent D., and Biddinger SB Nature communications, 2015/04/07, Volume 6, p.6498, (2015) Read More / View Supplemental Materials
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IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins.Dai, N., Zhao L., Wrighting D., Krämer D., Majithia A., Wang Y., Cracan V., Borges-Rivera D., Mootha VK, Nahrendorf M., Thorburn DR, Minichiello L., Altshuler D., and Avruch J. Cell metabolism, 2015/04/07, Volume 21, Issue 4, p.609-21, (2015) Read More / View Supplemental Materials
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Reproducibility in science.Yaffe, MB Science signaling, 2015/04/07, Volume 8, Issue 371, p.eg5, (2015) Read More / View Supplemental Materials
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Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction.Akizu, N., Cantagrel V., Zaki MS, Al-Gazali L., Wang X., Rosti RO, Dikoglu E., Gelot AB, Rosti B., Vaux KK, Scott EM, Silhavy JL, Schroth J., Copeland B., Schaffer AE, Gordts PL, Esko JD, Buschman MD, Field SJ, Napolitano G., et al. Nature genetics, 2015/04/06, (2015) Read More / View Supplemental Materials
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The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration.Cox, AG, and Goessling W. Current opinion in genetics & development, 2015/04/06, Volume 32, p.153-161, (2015) Read More / View Supplemental Materials
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The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.Ramirez-Ortiz, ZG, Prasad A., Griffith JW, Pendergraft WF 3rd, Cowley GS, Root DE, Tai M., Luster AD, El Khoury J., Hacohen N., and Means TK Nature immunology, 2015/04/06, (2015) Read More / View Supplemental Materials
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Cancer and the microbiota.Garrett, WS Science (New York, N.Y.), 2015/04/03, Volume 348, Issue 6230, p.80-6, (2015) Read More / View Supplemental Materials
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Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries.Beaudoin, M., Gupta RM, Won HH, Lo KS, Do R., Henderson CA, Lavoie-St-Amour C., Langlois S., Rivas D., Lehoux S., Kathiresan S., Tardif JC, Musunuru K., and Lettre G. Arteriosclerosis, thrombosis, and vascular biology, 2015/04/02, (2015) Read More / View Supplemental Materials
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Association of a brain methylation site with clinical outcomes in depression does not replicate across populations.Uher, R., Ripke S., Müller-Myhsok B., Lewis CM, and Perlis RH The American journal of psychiatry, 2015/04/01, Volume 172, Issue 4, p.395-7, (2015) Read More / View Supplemental Materials
Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.Dockendorff, C., Faloon PW, Pu J., Yu M., Johnston S., Bennion M., Penman M., Nieland TJ, Dandapani S., Perez JR, Munoz B., Palmer MA, Schreiber SL, and Krieger M. Bioorganic & medicinal chemistry letters, 2015/04/01, (2015) Read More / View Supplemental Materials
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Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations.Ahronian, LG, Sennott EM, Van Allen EM, Wagle N., Kwak EL, Faris JE, Godfrey JT, Nishimura K., Lynch KD, Mermel CH, Lockerman EL, Kalsy A., Gurski JM Jr, Bahl S., Anderka K., Green LM, Lennon NJ, Huynh TG, Mino-Kenudson M., Getz G., et al. Cancer discovery, 2015/04/01, Volume 5, Issue 4, p.358-67, (2015) Read More / View Supplemental Materials
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Dynamic epigenetic regulation by menin during pancreatic islet tumor formation.Lin, W., Watanabe H., Peng S., Francis JM, Kaplan N., Pedamallu CS, Ramachandran A., Agoston A., Bass AJ, and Meyerson M. Molecular cancer research : MCR, 2015/04/01, Volume 13, Issue 4, p.689-98, (2015) Read More / View Supplemental Materials
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Frozen Encapsulated Stool in Recurrent Clostridium difficile: Exploring the Role of Pills in the Treatment Hierarchy of Fecal Microbiota Transplant Nonresponders.Stollman, N., Smith M., Giovanelli A., Mendolia G., Burns L., Didyk E., Burgess J., Noh A., Edelstein C., Alm E., and Kassam Z. The American journal of gastroenterology, 2015/04/01, Volume 110, Issue 4, p.600-1, (2015) Read More / View Supplemental Materials
Haematological malignancies: at the forefront of immunotherapeutic innovation.Bachireddy, P., Burkhardt UE, Rajasagi M., and Wu CJ Nature reviews. Cancer, 2015/04/01, Volume 15, Issue 4, p.201-15, (2015) Read More / View Supplemental Materials
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HDAC3 inhibition improves glycemia and insulin secretion in obese diabetic rats.Lundh, M., Galbo T., Poulsen SS, and Mandrup-Poulsen T. Diabetes, obesity & metabolism, 2015/04/01, (2015) Read More / View Supplemental Materials
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Loss of PCLO function underlies pontocerebellar hypoplasia type III.Ahmed, MY, Chioza BA, Rajab A., Schmitz-Abe K., Al-Khayat A., Al-Turki S., Baple EL, Patton MA, Al-Memar AY, Hurles ME, Partlow JN, Hill RS, Evrony GD, Servattalab S., Markianos K., Walsh CA, Crosby AH, and Mochida GH Neurology, 2015/04/01, (2015) Read More / View Supplemental Materials
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A microbiological revolution meets an ancient disease: improving the management of tuberculosis with genomics.Wlodarska, M., Johnston JC, Gardy JL, and Tang P. Clinical microbiology reviews, 2015/04/01, Volume 28, Issue 2, p.523-39, (2015) Read More / View Supplemental Materials
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miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma.Kouri, FM, Hurley LA, Daniel WL, Day ES, Hua Y., Hao L., Peng CY, Merkel TJ, Queisser MA, Ritner C., Zhang H., James CD, Sznajder JI, Chin L., Giljohann DA, Kessler JA, Peter ME, Mirkin CA, and Stegh AH Genes & development, 2015/04/01, Volume 29, Issue 7, p.732-45, (2015) Read More / View Supplemental Materials
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Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia: A Danish Population-Based Study and Meta-analysis.Agerbo, E., Sullivan PF, Vilhjálmsson BJ, Pedersen CB, Mors O., Børglum AD, Hougaard DM, Hollegaard MV, Meier S., Mattheisen M., Ripke S., Wray NR, and Mortensen PB JAMA psychiatry, 2015/04/01, (2015) Read More / View Supplemental Materials
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The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease.Moutsianas, L., Agarwala V., Fuchsberger C., Flannick J., Rivas MA, Gaulton KJ, Albers PK, GoT2D Consortium, McVean G., Boehnke M., Altshuler D., and McCarthy MI PLoS genetics, 2015/04/01, Volume 11, Issue 4, p.e1005165, (2015) Read More / View Supplemental Materials
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Precision medicine in breast cancer: genes, genomes, and the future of genomically driven treatments.Stover, DG, and Wagle N. Current oncology reports, 2015/04/01, Volume 17, Issue 4, p.15, (2015) Read More / View Supplemental Materials
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Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq.Fuchs, G., Voichek Y., Rabani M., Benjamin S., Gilad S., Amit I., and Oren M. Nature protocols, 2015/04/01, Volume 10, Issue 4, p.605-18, (2015) Read More / View Supplemental Materials
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The tumor virus landscape of AIDS-related lymphomas.Arvey, A., Ojesina A., Pedamallu CS, Ballon G., Jung J., Duke F., Leoncini L., De Falco G., Bressman E., Tam W., Chadburn A., Meyerson M., and Cesarman E. Blood, 2015/03/31, (2015) Read More / View Supplemental Materials
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DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.Chen, CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N., Eng R., Doench JG, Xu H., Chu SH, Qi J., Wang X., Delaney C., Bernt KM, Root DE, Hahn WC, Bradner JE, and Armstrong SA Nature medicine, 2015/03/30, (2015) Read More / View Supplemental Materials
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Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.Liao, J., Karnik R., Gu H., Ziller MJ, Clement K., Tsankov AM, Akopian V., Gifford CA, Donaghey J., Galonska C., Pop R., Reyon D., Tsai SQ, Mallard W., Joung JK, Rinn JL, Gnirke A., and Meissner A. Nature genetics, 2015/03/30, (2015) Read More / View Supplemental Materials
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Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype.Bergthold, G., Bandopadhayay P., Hoshida Y., Ramkissoon S., Ramkissoon L., Rich B., Maire CL, Paolella BR, Schumacher SE, Tabak B., Ferrer-Luna R., Ozek M., Sav A., Santagata S., Wen PY, Goumnerova LC, Ligon AH, Stiles C., Segal R., Golub T., et al. Neuro-oncology, 2015/03/29, (2015) Read More / View Supplemental Materials
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Unique patterns of transcript and miRNA expression in the South American strong voltage electric eel (Electrophorus electricus).Traeger, LL, Volkening JD, Moffett H., Gallant JR, Chen PH, Novina CD, Phillips GN Jr, Anand R., Wells GB, Pinch M., Güth R., Unguez GA, Albert JS, Zakon H., Sussman MR, and Samanta MP BMC genomics, 2015/03/26, Volume 16, p.243, (2015) Read More / View Supplemental Materials
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ImmVar project: Insights and design considerations for future studies of "healthy" immune variation.De Jager, PL, Hacohen N., Mathis D., Regev A., Stranger BE, and Benoist C. Seminars in immunology, 2015/03/25, (2015) Read More / View Supplemental Materials
Abstract
Non-crossover gene conversions show strong GC bias and unexpected clustering in humans.Williams, AL, Genovese G., Dyer T., Altemose N., Truax K., Jun G., Patterson N., Myers SR, Curran JE, Duggirala R., Blangero J., Reich D., and Przeworski M. eLife, 2015/03/25, Volume 4, (2015) Read More / View Supplemental Materials
Abstract
PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration Resistant Prostate Cancer, is a Mediator of Resistance to Androgen Deprivation Therapy.Hsieh, CL, Botta G., Gao S., Li T., Van Allen EM, Treacy DJ, Cai C., He HH, Sweeney CJ, Brown M., Balk SP, Nelson PS, Garraway LA, and Kantoff PW Cancer research, 2015/03/25, (2015) Read More / View Supplemental Materials
Abstract
Association of a 62 Variant Type 2 Diabetes Genetic Risk Score with Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study.Dauriz, M., Porneala BC, Guo X., Bielak LF, Peyser PA, Durant NH, Carnethon MR, Bonadonna RC, Bonora E., Bowden DW, Florez JC, Fornage M., Hivert MF, Jacobs DR Jr, Kabagambe EK, Lewis CE, Murabito JM, Rasmussen-Torvik LJ, Rich SS, Vassy JL, et al. Circulation. Cardiovascular genetics, 2015/03/24, (2015) Read More / View Supplemental Materials
Abstract
Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.Edri, R., Yaffe Y., Ziller MJ, Mutukula N., Volkman R., David E., Jacob-Hirsch J., Malcov H., Levy C., Rechavi G., Gat-Viks I., Meissner A., and Elkabetz Y. Nature communications, 2015/03/23, Volume 6, p.6500, (2015) Read More / View Supplemental Materials
Abstract
Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation.Esrick, EB, McConkey M., Lin K., Frisbee A., and Ebert BL American journal of hematology, 2015/03/23, (2015) Read More / View Supplemental Materials
Abstract
Dimethylglycine Deficiency and the Development of Diabetes mellitus.Magnusson, M., Wang TJ, Clish C., Engström G., Nilsson P., Gerszten RE, and Melander O. Diabetes, 2015/03/20, (2015) Read More / View Supplemental Materials
Abstract
ARID1A and TERT promoter mutations in dedifferentiated meningioma.Abedalthagafi, MS, Bi WL, Merrill PH, Gibson WJ, Rose MF, Du Z., Francis JM, Du R., Dunn IF, Ligon AH, Beroukhim R., and Santagata S. Cancer genetics, 2015/03/18, (2015) Read More / View Supplemental Materials
Abstract
Rare Genetic Variants in the CFI Gene are Associated with Advanced Age-Related Macular Degeneration and Commonly Result in Reduced Serum Factor I Levels.Kavanagh, D., Yu Y., Schramm EC, Triebwasser M., Wagner E., Raychaudhuri S., Daly M. J., Atkinson JP, and Seddon JM Human molecular genetics, 2015/03/18, (2015) Read More / View Supplemental Materials
Abstract
CHD2 variants are a risk factor for photosensitivity in epilepsy.Galizia, EC, Myers CT, Leu C., de Kovel CG, Afrikanova T., Cordero-Maldonado ML, Martins TG, Jacmin M., Drury S., Krishna Chinthapalli V., Muhle H., Pendziwiat M., Sander T., Ruppert AK, Møller RS, Thiele H., Krause R., Schubert J., Lehesjoki AE, Nürnberg P., et al. Brain : a journal of neurology, 2015/03/17, (2015) Read More / View Supplemental Materials
Abstract
Contribution of common non-synonymous variants in PCSK1 to body-mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331,175 individuals.Nead, KT, Li A., Wehner MR, Neupane B., Gustafsson S., Butterworth A., Engert JC, Davis AD, Hegele RA, Miller R., den Hoed M., Khaw KT, Kilpeläinen TO, Wareham N., Edwards TL, Hallmans G., Varga TV, Kardia SL, Smith JA, Zhao W., et al. Human molecular genetics, 2015/03/17, (2015) Read More / View Supplemental Materials
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Linking traits based on their shared molecular mechanisms.Oren, Y., Nachshon A., Frishberg A., Wilentzik R., and Gat-Viks I. eLife, 2015/03/17, Volume 4, (2015) Read More / View Supplemental Materials
Abstract
A novel Alzheimer disease locus located near the gene encoding tau protein.Jun, G., Ibrahim-Verbaas CA, Vronskaya M., Lambert JC, Chung J., Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C., Harold D., Lunetta KL, Destefano AL, Grenier-Boley B., Sims R., Beecham GW, Smith AV, Chouraki V., Hamilton-Nelson KL, Ikram MA, et al. Molecular psychiatry, 2015/03/17, (2015) Read More / View Supplemental Materials
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Temporal trends in the incidence and prognosis of aortic stenosis: a nationwide study of the Swedish population.Martinsson, A., Li X., Andersson C., Nilsson J., Smith JG, and Sundquist K. Circulation, 2015/03/17, Volume 131, Issue 11, p.988-94, (2015) Read More / View Supplemental Materials
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Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.Strohecker, AM, Joshi S., Possemato R., Abraham RT, Sabatini DM, and White E. Oncogene, 2015/03/16, (2015) Read More / View Supplemental Materials
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Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.Wang, S., Li N., Yousefi M., Nakauka-Ddamba A., Li F., Parada K., Rao S., Minuesa G., Katz Y., Gregory BD, Kharas MG, Yu Z., and Lengner CJ Nature communications, 2015/03/16, Volume 6, p.6517, (2015) Read More / View Supplemental Materials
Abstract
Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants.Park, AK, Francis JM, Park WY, Park JO, and Cho J. Oncotarget, 2015/03/12, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis.Chen, S., Sanjana NE, Zheng K., Shalem O., Lee K., Shi X., Scott DA, Song J., Pan JQ, Weissleder R., Lee H., Zhang F., and Sharp PA Cell, 2015/03/12, Volume 160, Issue 6, p.1246-60, (2015) Read More / View Supplemental Materials
Abstract
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.Niederst, MJ, Sequist LV, Poirier JT, Mermel CH, Lockerman EL, Garcia AR, Katayama R., Costa C., Ross KN, Moran T., Howe E., Fulton LE, Mulvey HE, Bernardo LA, Mohamoud F., Miyoshi N., VanderLaan PA, Costa DB, Jänne PA, Borger DR, et al. Nature communications, 2015/03/11, Volume 6, p.6377, (2015) Read More / View Supplemental Materials
Abstract
Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma.Ramkissoon, SH, Bi WL, Schumacher SE, Ramkissoon LA, Haidar S., Knoff D., Dubuc A., Brown L., Burns M., Cryan JB, Abedalthagafi M., Kang YJ, Schultz N., Reardon DA, Lee EQ, Rinne ML, Norden AD, Nayak L., Ruland S., Doherty LM, et al. Neuro-oncology, 2015/03/09, (2015) Read More / View Supplemental Materials
Abstract
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.Onengut-Gumuscu, S., Chen WM, Burren O., Cooper NJ, Quinlan AR, Mychaleckyj JC, Farber E., Bonnie JK, Szpak M., Schofield E., Achuthan P., Guo H., Fortune MD, Stevens H., Walker NM, Ward LD, Kundaje A., Kellis M., Daly M. J., Barrett JC, et al. Nature genetics, 2015/03/09, (2015) Read More / View Supplemental Materials
Abstract
A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer.Wilson, FH, Johannessen CM, Piccioni F., Tamayo P., Kim JW, Van Allen EM, Corsello SM, Capelletti M., Calles A., Butaney M., Sharifnia T., Gabriel SB, Mesirov J. P., Hahn WC, Engelman JA, Meyerson M., Root DE, Jänne PA, and Garraway LA Cancer cell, 2015/03/09, Volume 27, Issue 3, p.397-408, (2015) Read More / View Supplemental Materials
Abstract
Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens.Jovanovic, M., Rooney MS, Mertins P., Przybylski D., Chevrier N., Satija R., Rodriguez EH, Fields AP, Schwartz S., Raychowdhury R., Mumbach MR, Eisenhaure T., Rabani M., Gennert D., Lu D., Delorey T., Weissman JS, Carr SA, Hacohen N., and Regev A. Science (New York, N.Y.), 2015/03/06, Volume 347, Issue 6226, p.1259038, (2015) Read More / View Supplemental Materials
Abstract
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