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2016
Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium.Amendola, LM, Jarvik GP, Leo MC, McLaughlin HM, Akkari Y., Amaral MD, Berg JS, Biswas S., Bowling KM, Conlin LK, Cooper GM, Dorschner MO, Dulik MC, Ghazani AA, Ghosh R., Green RC, Hart R., Horton C., Johnston JJ, Lebo MS, et al. American journal of human genetics, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing.Degrauwe, N., Schlumpf TB, Janiszewska M., Martin P., Cauderay A., Provero P., Riggi N., Suvà ML, Paro R., and Stamenkovic I. Cell reports, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.Kugel, S., Sebastián C., Fitamant J., Ross KN, Saha SK, Jain E., Gladden A., Arora KS, Kato Y., Rivera MN, Ramaswamy S., Sadreyev RI, Goren A., Deshpande V., Bardeesy N., and Mostoslavsky R. Cell, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures.Wang, X., Tucker NR, Rizki G., Mills R., Krijger PH, de Wit E., Subramanian V., Bartell E., Nguyen XX, Ye J., Leyton-Mange J., Dolmatova EV, van der Harst P., de Laat W., Ellinor PT, Newton-Cheh C., Milan DJ, Kellis M., and Boyer LA eLife, 2016/05/10, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
Massive contribution of transposable elements to mammalian regulatory sequences.Rayan, NA, Del Rosario RC, and Prabhakar S. Seminars in cell & developmental biology, 2016/05/10, (2016) Read More / View Supplemental Materials
Abstract
Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits.Robinson, JE, Hastie KM, Cross RW, Yenni RE, Elliott DH, Rouelle JA, Kannadka CB, Smira AA, Garry CE, Bradley BT, Yu H., Shaffer JG, Boisen ML, Hartnett JN, Zandonatti MA, Rowland MM, Heinrich ML, Martínez-Sobrido L., Cheng B., de la Torre JC, et al. Nature communications, 2016/05/10, Volume 7, p.11544, (2016) Read More / View Supplemental Materials
Abstract
Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth.Holst, F., Hoivik EA, Gibson WJ, Taylor-Weiner A., Schumacher SE, Asmann YW, Grossmann P., Trovik J., Necela BM, Thompson EA, Meyerson M., Beroukhim R., Salvesen HB, and Cherniack AD Scientific reports, 2016/05/10, Volume 6, p.25521, (2016) Read More / View Supplemental Materials
Abstract
Adult axolotls can regenerate original neuronal diversity in response to brain injury.Amamoto, R., Huerta VG, Takahashi E., Dai G., Grant AK, Fu Z., and Arlotta P. eLife, 2016/05/09, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.Lamas, B., Richard ML, Leducq V., Pham HP, Michel ML, Da Costa G., Bridonneau C., Jegou S., Hoffmann TW, Natividad JM, Brot L., Taleb S., Couturier-Maillard A., Nion-Larmurier I., Merabtene F., Seksik P., Bourrier A., Cosnes J., Ryffel B., Beaugerie L., et al. Nature medicine, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma.Zheng, S., Cherniack AD, Dewal N., Moffitt RA, Danilova L., Murray BA, Lerario AM, Else T., Knijnenburg TA, Ciriello G., Kim S., Assie G., Morozova O., Akbani R., Shih J., Hoadley KA, Choueiri TK, Waldmann J., Mete O., Robertson AG, et al. Cancer cell, 2016/05/09, Volume 29, Issue 5, p.723-36, (2016) Read More / View Supplemental Materials
Abstract
Diagnosis and aetiology of congenital muscular dystrophy: we are halfway there.O'Grady, GL, Lek M., Lamande SR, Waddell L., Oates EC, Punetha J., Ghaoui R., Sandaradura SA, Best H., Kaur S., Davis M., Laing NG, Muntoni F., Hoffman E., Macarthur DG, Clarke NF, Cooper S., and North K. Annals of neurology, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas.Campbell, JD, Alexandrov A., Kim J., Wala J., Berger AH, Pedamallu CS, Shukla SA, Guo G., Brooks AN, Murray BA, Imielinski M., Hu X., Ling S., Akbani R., Rosenberg M., Cibulskis C., Ramachandran A., Collisson EA, Kwiatkowski DJ, Lawrence MS, et al. Nature genetics, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide association study of generalized anxiety symptoms in the Hispanic Community Health Study/Study of Latinos.Dunn, EC, Sofer T., Gallo LC, Gogarten SM, Kerr KF, Chen CY, Stein MB, Ursano RJ, Guo X., Jia Y., Qi Q., Rotter JI, Argos M., Cai J., Penedo FJ, Perreira K., Wassertheil-Smoller S., and Smoller JW American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
MAPK activation and HRAS mutation identified in pituitary spindle cell oncocytoma.Miller, MB, Bi WL, Ramkissoon LA, Kang YJ, Abedalthagafi M., Knoff DS, Agarwalla PK, Wen PY, Reardon DA, Alexander BM, Laws ER Jr, Dunn IF, Beroukhim R., Ligon KL, and Ramkissoon SH Oncotarget, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.Diaz-Horta, O., Abad C., Sennaroglu L., Foster J 2nd, DeSmidt A., Bademci G., Tokgoz-Yilmaz S., Duman D., Cengiz FB, Grati M., Fitoz S., Liu XZ, Farooq A., Imtiaz F., Currall BB, Morton CC, Nishita M., Minami Y., Lu Z., Walz K., et al. Proceedings of the National Academy of Sciences of the United States of America, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.Rothhammer, V., Mascanfroni ID, Bunse L., Takenaka MC, Kenison JE, Mayo L., Chao CC, Patel B., Yan R., Blain M., Alvarez JI, Kébir H., Anandasabapathy N., Izquierdo G., Jung S., Obholzer N., Pochet N., Clish CB, Prinz M., Prat A., et al. Nature medicine, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Comparative transcriptomics across the prokaryotic tree of life.Cohen, O., Doron S., Wurtzel O., Dar D., Edelheit S., Karunker I., Mick E., and Sorek R. Nucleic acids research, 2016/05/06, (2016) Read More / View Supplemental Materials
Abstract
Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components.Pardee, K., Green AA, Takahashi MK, Braff D., Lambert G., Lee JW, Ferrante T., Ma D., Donghia N., Fan M., Daringer NM, Bosch I., Dudley DM, O'Connor DH, Gehrke L., and Collins JJ Cell, 2016/05/06, (2016) Read More / View Supplemental Materials
Abstract
Single-molecule decoding of combinatorially modified nucleosomes.Shema, E., Jones D., Shoresh N., Donohue L., Ram O., and Bernstein BE Science (New York, N.Y.), 2016/05/06, Volume 352, Issue 6286, p.717-21, (2016) Read More / View Supplemental Materials
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An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1.Lorberbaum, DS, Ramos AI, Peterson KA, Carpenter BS, Parker DS, De S., Hillers LE, Blake VM, Nishi Y., McFarlane MR, Chiang AC, Kassis JA, Allen BL, McMahon AP, and Barolo S. eLife, 2016/05/05, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
A comparative assessment of clinical whole exome and transcriptome profiling across sequencing centers: Implications for precision cancer medicine.Allen, EM, Robinson D., Morrissey C., Pritchard C., Imamovic A., Carter S., Rosenberg M., McKenna A., Wu YM, Cao X., Chinnaiyan A., Garraway L., and Nelson PS Oncotarget, 2016/05/05, (2016) Read More / View Supplemental Materials
Abstract
CSF1R mosaicism in a family with hereditary diffuse leukoencephalopathy with spheroids.Eichler, FS, Li J., Guo Y., Caruso PA, Bjonnes AC, Pan J., Booker JK, Lane JM, Tare A., Vlasac I., Hakonarson H., Gusella JF, Zhang J., Keating BJ, and Saxena R. Brain : a journal of neurology, 2016/05/05, (2016) Read More / View Supplemental Materials
Abstract
Development and Validation of a Mass Spectrometry-Based Assay for the Molecular Diagnosis of Mucin-1 Kidney Disease.Blumenstiel, B., DeFelice M., Birsoy O., Bleyer AJ, Kmoch S., Carter TA, Gnirke A., Kidd K., Rehm HL, Ronco L., Lander E. S., Gabriel S., and Lennon NJ The Journal of molecular diagnostics : JMD, 2016/05/05, (2016) Read More / View Supplemental Materials
Abstract
Population-Scale Sequencing Data Enable Precise Estimates of Y-STR Mutation Rates.Willems, T., Gymrek M., Poznik GD, Tyler-Smith C., 1000 Genomes Project Chromosome Y Group, and Erlich Y. American journal of human genetics, 2016/05/05, Volume 98, Issue 5, p.919-33, (2016) Read More / View Supplemental Materials
Abstract
Tumour CD274 (PD-L1) expression and T cells in colorectal cancer.Masugi, Y., Nishihara R., Yang J., Mima K., da Silva A., Shi Y., Inamura K., Cao Y., Song M., Nowak JA, Liao X., Nosho K., Chan AT, Giannakis M., Bass AJ, Hodi FS, Freeman GJ, Rodig S., Fuchs CS, Qian ZR, et al. Gut, 2016/05/05, (2016) Read More / View Supplemental Materials
Abstract
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.Vatanen, T., Kostic AD, d'Hennezel E., Siljander H., Franzosa EA, Yassour M., Kolde R., Vlamakis H., Arthur TD, Hämäläinen AM, Peet A., Tillmann V., Uibo R., Mokurov S., Dorshakova N., Ilonen J., Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H., et al. Cell, 2016/05/05, Volume 165, Issue 4, p.842-53, (2016) Read More / View Supplemental Materials
Abstract
Antidepressant-like effect of low dose ketamine and scopolamine co-treatment in mice.Petryshen, TL, Lewis MC, Dennehy KA, Garza JC, and Fava M. Neuroscience letters, 2016/05/04, Volume 620, p.70-3, (2016) Read More / View Supplemental Materials
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Enrichment of rare variants in population isolates: single AICDA mutation responsible for hyper-IgM syndrome type 2 in Finland.Trotta, L., Hautala T., Hämäläinen S., Syrjänen J., Viskari H., Almusa H., Lepisto M., Kaustio M., Porkka K., Palotie A., Seppänen M., and Saarela J. European journal of human genetics : EJHG, 2016/05/04, (2016) Read More / View Supplemental Materials
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Systematic functional interrogation of rare cancer variants identifies oncogenic alleles.Kim, E., Ilic N., Shrestha Y., Zou L., Kamburov A., Zhu C., Yang X., Lubonja R., Tran N., Nguyen C., Lawrence MS, Piccioni F., Bagul M., Doench JG, Chouinard CR, Wu X., Hogstrom L., Natoli T., Tamayo P., Horn H., et al. Cancer discovery, 2016/05/04, (2016) Read More / View Supplemental Materials
Abstract
Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes.Taleban, S., Stewart KO, Li DK, Singh P., Pardi DS, Sturgeon HC, Yajnik V., Xavier RJ, Ananthakrishnan AN, and Khalili H. Digestive diseases and sciences, 2016/05/03, (2016) Read More / View Supplemental Materials
Abstract
COMT Val158 Met genotype is associated with reward learning: A replication study and meta-analysis.Corral-Frías, NS, Pizzagalli DA, Carré J., Michalski LJ, Nikolova YS, Perlis RH, Fagerness J., Lee MR, Drabant Conley E., Lancaster TM, Haddad S., Wolf A., Smoller JW, Hariri AR, and Bogdan R. Genes, brain, and behavior, 2016/05/03, (2016) Read More / View Supplemental Materials
Abstract
A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs.Raffan, E., Dennis RJ, O'Donovan CJ, Becker JM, Scott RA, Smith SP, Withers DJ, Wood CJ, Conci E., Clements DN, Summers KM, German AJ, Mellersh CS, Arendt ML, Iyemere VP, Withers E., Söder J., Wernersson S., Andersson G., Lindblad-Toh K., et al. Cell metabolism, 2016/05/02, (2016) Read More / View Supplemental Materials
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The genetic history of Ice Age Europe.Fu, Q., Posth C., Hajdinjak M., Petr M., Mallick S., Fernandes D., Furtwängler A., Haak W., Meyer M., Mittnik A., Nickel B., Peltzer A., Rohland N., Slon V., Talamo S., Lazaridis I., Lipson M., Mathieson I., Schiffels S., Skoglund P., et al. Nature, 2016/05/02, (2016) Read More / View Supplemental Materials
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A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years.Moorjani, P., Sankararaman S., Fu Q., Przeworski M., Patterson N., and Reich D. Proceedings of the National Academy of Sciences of the United States of America, 2016/05/02, (2016) Read More / View Supplemental Materials
Abstract
Lower prevalence but similar fitness in a parasitic fungus at higher radiation levels near Chernobyl.Aguileta, G., Badouin H., Hood ME, Møller AP, Le Prieur S., Snirc A., Siguenza S., Mousseau TA, Shykoff JA, Cuomo CA, and Giraud T. Molecular ecology, 2016/05/02, (2016) Read More / View Supplemental Materials
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Atrial Fibrillation and Declining Physical Performance in Older Adults: The Health, Aging, and Body Composition Study.Magnani, JW, Wang N., Benjamin EJ, Garcia ME, Bauer DC, Butler J., Ellinor PT, Kritchevsky S., Marcus GM, Newman A., Phillips CL, Sasai H., Satterfield S., Sullivan LM, Harris TB, and and Health, Aging Body Composition Study Circulation. Arrhythmia and electrophysiology, 2016/05/01, Volume 9, Issue 5, p.e003525, (2016) Read More / View Supplemental Materials
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The Contribution of GWAS Loci in Familial Dyslipidemias.Ripatti, P., Rämö JT, Söderlund S., Surakka I., Matikainen N., Pirinen M., Pajukanta P., Sarin AP, Service SK, Laurila PP, Ehnholm C., Salomaa V., Wilson RK, Palotie A., Freimer NB, Taskinen MR, and Ripatti S. PLoS genetics, 2016/05/01, Volume 12, Issue 5, p.e1006078, (2016) Read More / View Supplemental Materials
Abstract
Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.Tully, DC, Ogilvie CB, Batorsky RE, Bean DJ, Power KA, Ghebremichael M., Bedard HE, Gladden AD, Seese AM, Amero MA, Lane K., McGrath G., Bazner SB, Tinsley J., Lennon NJ, Henn MR, Brumme ZL, Norris PJ, Rosenberg ES, Mayer KH, et al. PLoS pathogens, 2016/05/01, Volume 12, Issue 5, p.e1005619, (2016) Read More / View Supplemental Materials
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Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure.Smith, JG, Felix JF, Morrison AC, Kalogeropoulos A., Trompet S., Wilk JB, Gidlöf O., Wang X., Morley M., Mendelson M., Joehanes R., Ligthart S., Shan X., Bis JC, Wang YA, Sjögren M., Ngwa J., Brandimarto J., Stott DJ, Aguilar D., et al. PLoS genetics, 2016/05/01, Volume 12, Issue 5, p.e1006034, (2016) Read More / View Supplemental Materials
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Genome-Wide Analysis Identifies Germ-Line Risk Factors Associated with Canine Mammary Tumours.Melin, M., Rivera P., Arendt M., Elvers I., Murén E., Gustafson U., Starkey M., Borge KS, Lingaas F., Häggström J., Saellström S., Rönnberg H., and Lindblad-Toh K. PLoS genetics, 2016/05/01, Volume 12, Issue 5, p.e1006029, (2016) Read More / View Supplemental Materials
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Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis.Guasch-Ferré, M., Hruby A., Toledo E., Clish CB, Martínez-González MA, Salas-Salvadó J., and Hu FB Diabetes care, 2016/05/01, Volume 39, Issue 5, p.833-46, (2016) Read More / View Supplemental Materials
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Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes.Abelin, JG, Patel J., Lu X., Feeney CM, Fagbami L., Creech AL, Hu R., Lam D., Davison D., Pino L., Qiao JW, Kuhn E., Officer A., Li J., Abbatiello S., Subramanian A., Sidman R., Snyder E., Carr SA, and Jaffe JD Molecular & cellular proteomics : MCP, 2016/05/01, Volume 15, Issue 5, p.1622-41, (2016) Read More / View Supplemental Materials
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Silencing FOXP2 in breast cancer cells promotes cancer stem cell traits and metastasis.Cuiffo, BG, and Karnoub AE Molecular & cellular oncology, 2016/05/01, Volume 3, Issue 3, p.e1019022, (2016) Read More / View Supplemental Materials
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Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus.Truvé, K., Dickinson P., Xiong A., York D., Jayashankar K., Pielberg G., Koltookian M., Murén E., Fuxelius HH, Weishaupt H., Swartling FJ, Andersson G., Hedhammar Å., Bongcam-Rudloff E., Forsberg-Nilsson K., Bannasch D., and Lindblad-Toh K. PLoS genetics, 2016/05/01, Volume 12, Issue 5, p.e1006000, (2016) Read More / View Supplemental Materials
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Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.Zhernakova, A., Kurilshikov A., Bonder MJ, Tigchelaar EF, Schirmer M., Vatanen T., Mujagic Z., Vila AV, Falony G., Vieira-Silva S., Wang J., Imhann F., Brandsma E., Jankipersadsing SA, Joossens M., Cenit MC, Deelen P., Swertz MA, study LifeLines Cohort, Weersma RK, et al. Science (New York, N.Y.), 2016/04/29, Volume 352, Issue 6285, p.565-9, (2016) Read More / View Supplemental Materials
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Subacute decline in serum lipids precedes the occurrence of primary intracerebral hemorrhage.Phuah, CL, Raffeld MR, Ayres AM, Viswanathan A., Greenberg SM, Biffi A., Rosand J., and Anderson CD Neurology, 2016/04/29, (2016) Read More / View Supplemental Materials
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Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers.Derks, S., Liao X., Chiaravalli AM, Xu X., Camargo MC, Solcia E., Sessa F., Fleitas T., Freeman GJ, Rodig SJ, Rabkin CS, and Bass AJ Oncotarget, 2016/04/28, (2016) Read More / View Supplemental Materials
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CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq.Hashimshony, T., Senderovich N., Avital G., Klochendler A., de Leeuw Y., Anavy L., Gennert D., Li S., Livak KJ, Rozenblatt-Rosen O., Dor Y., Regev A., and Yanai I. Genome biology, 2016/04/28, Volume 17, Issue 1, p.77, (2016) Read More / View Supplemental Materials
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Clinical, Molecular, and Immune Analysis of Dabrafenib-Trametinib Combination Treatment for BRAF Inhibitor-Refractory Metastatic Melanoma: A Phase 2 Clinical Trial.Chen, G., McQuade JL, Panka DJ, Hudgens CW, Amin-Mansour A., Mu XJ, Bahl S., Jané-Valbuena J., Wani KM, Reuben A., Creasy CA, Jiang H., Cooper ZA, Roszik J., Bassett RL Jr, Joon AY, Simpson LM, Mouton RD, Glitza IC, Patel SP, et al. JAMA oncology, 2016/04/28, (2016) Read More / View Supplemental Materials
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A Clinician's perspective on clinical exome sequencing.O'Donnell-Luria, AH, and Miller DT Human genetics, 2016/04/28, (2016) Read More / View Supplemental Materials
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Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.Dayton, TL, Gocheva V., Miller KM, Israelsen WJ, Bhutkar A., Clish CB, Davidson SM, Luengo A., Bronson RT, Jacks T., and Vander Heiden MG Genes & development, 2016/04/28, (2016) Read More / View Supplemental Materials
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The healthy human microbiome.Lloyd-Price, J., Abu-Ali G., and Huttenhower C. Genome medicine, 2016/04/27, Volume 8, Issue 1, p.51, (2016) Read More / View Supplemental Materials
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IRF7 inhibition prevents destructive innate immunity-A target for nonantibiotic therapy of bacterial infections.Puthia, M., Ambite I., Cafaro C., Butler D., Huang Y., Lutay N., Rydström G., Gullstrand B., Swaminathan B., Nadeem A., Nilsson B., and Svanborg C. Science translational medicine, 2016/04/27, Volume 8, Issue 336, p.336ra59, (2016) Read More / View Supplemental Materials
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Neurobiology of social behavior abnormalities in autism and Williams syndrome.Barak, B., and Feng G. Nature neuroscience, 2016/04/26, Volume 19, Issue 6, p.647-55, (2016) Read More / View Supplemental Materials
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A Spectrum of CodY Activities Drives Metabolic Reorganization and Virulence Gene Expression in Staphylococcus aureus.Waters, NR, Samuels DJ, Behera RK, Livny J., Rhee KY, Sadykov MR, and Brinsmade SR Molecular microbiology, 2016/04/26, (2016) Read More / View Supplemental Materials
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A genetic basis for the variation in the vulnerability of cancer to DNA damage.Yard, BD, Adams DJ, Chie EK, Tamayo P., Battaglia JS, Gopal P., Rogacki K., Pearson BE, Phillips J., Raymond DP, Pennell NA, Almeida F., Cheah JH, Clemons PA, Shamji A., Peacock CD, Schreiber SL, Hammerman PS, and Abazeed ME Nature communications, 2016/04/25, Volume 7, p.11428, (2016) Read More / View Supplemental Materials
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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.Pacold, ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R., Chen WW, Sullivan LB, Fiske BP, Cho S., Freinkman E., Birsoy K., Abu-Remaileh M., Shaul YD, Liu CM, Zhou M., Koh MJ, Chung H., Davidson SM, et al. Nature chemical biology, 2016/04/25, (2016) Read More / View Supplemental Materials
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Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.Poznik, GD, Xue Y., Mendez FL, Willems TF, Massaia A., Wilson Sayres MA, Ayub Q., McCarthy SA, Narechania A., Kashin S., Chen Y., Banerjee R., Rodriguez-Flores JL, Cerezo M., Shao H., Gymrek M., Malhotra A., Louzada S., Desalle R., Ritchie GR, et al. Nature genetics, 2016/04/25, (2016) Read More / View Supplemental Materials
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Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors.Kim, J., Mouw KW, Polak P., Braunstein LZ, Kamburov A., Tiao G., Kwiatkowski DJ, Rosenberg JE, Van Allen EM, D'Andrea AD, and Getz G. Nature genetics, 2016/04/25, (2016) Read More / View Supplemental Materials
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Targeted erythropoietin selectively stimulates red blood cell expansion in vivo.Burrill, DR, Vernet A., Collins JJ, Silver PA, and Way JC Proceedings of the National Academy of Sciences of the United States of America, 2016/04/25, (2016) Read More / View Supplemental Materials
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An open-source computational tool to automatically quantify immunolabeled retinal ganglion cells.Dordea, AC, Bray MA, Allen K., Logan D., Fei F., Malhotra R., Gregory M., Carpenter AE, and Buys ES Experimental eye research, 2016/04/24, (2016) Read More / View Supplemental Materials
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Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution.Patel, AP, Peloso GM, Pirruccello JP, Johansen CT, Dubé JB, Larach DB, Ban MR, Dallinge-Thie GM, Gupta N., Boehnke M., Abecasis GR, Kastelein JJ, Hovingh GK, Hegele RA, Rader DJ, and Kathiresan S. Atherosclerosis, 2016/04/23, Volume 250, p.63-68, (2016) Read More / View Supplemental Materials
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Trained immunity: A program of innate immune memory in health and disease.Netea, MG, Joosten LA, Latz E., Mills KH, Natoli G., Stunnenberg HG, O'Neill LA, and Xavier RJ Science (New York, N.Y.), 2016/04/22, Volume 352, Issue 6284, p.aaf1098, (2016) Read More / View Supplemental Materials
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Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.Yamano, T., Nishimasu H., Zetsche B., Hirano H., Slaymaker IM, Li Y., Fedorova I., Nakane T., Makarova KS, Koonin EV, Ishitani R., Zhang F., and Nureki O. Cell, 2016/04/21, (2016) Read More / View Supplemental Materials
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Engineering Models to Scale.Dy, AJ, and Collins JJ Cell, 2016/04/21, Volume 165, Issue 3, p.516-7, (2016) Read More / View Supplemental Materials
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The influence of a short-term gluten-free diet on the human gut microbiome.Bonder, MJ, Tigchelaar EF, Cai X., Trynka G., Cenit MC, Hrdlickova B., Zhong H., Vatanen T., Gevers D., Wijmenga C., Wang Y., and Zhernakova A. Genome medicine, 2016/04/21, Volume 8, Issue 1, p.45, (2016) Read More / View Supplemental Materials
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PD-1 marks dysfunctional regulatory T cells in malignant gliomas.Lowther, DE, Goods BA, Lucca LE, Lerner BA, Raddassi K., van Dijk D., Hernandez AL, Duan X., Gunel M., Coric V., Krishnaswamy S., Love JC, and Hafler DA JCI insight, 2016/04/21, Volume 1, Issue 5, (2016) Read More / View Supplemental Materials
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High fat diet and stem cells: Linking diet to intestinal tumor formation.Cangelosi, AL, and Yilmaz Ö. H. Cell cycle (Georgetown, Tex.), 2016/04/20, (2016) Read More / View Supplemental Materials
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Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions.Guasch-Ferré, M., Zheng Y., Ruiz-Canela M., Hruby A., Martínez-González MA, Clish CB, Corella D., Estruch R., Ros E., Fitó M., Dennis C., Morales-Gil IM, Arós F., Fiol M., Lapetra J., Serra-Majem L., Hu FB, and Salas-Salvadó J. The American journal of clinical nutrition, 2016/04/20, (2016) Read More / View Supplemental Materials
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gkmSVM: an R package for gapped-kmer SVM.Ghandi, M., Mohammad-Noori M., Ghareghani N., Lee D., Garraway L., and Beer MA Bioinformatics (Oxford, England), 2016/04/19, (2016) Read More / View Supplemental Materials
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Characterizing genomic alterations in cancer by complementary functional associations.Kim, JW, Botvinnik OB, Abudayyeh O., Birger C., Rosenbluh J., Shrestha Y., Abazeed ME, Hammerman PS, Dicara D., Konieczkowski DJ, Johannessen CM, Liberzon A., Alizad-Rahvar AR, Alexe G., Aguirre A., Ghandi M., Greulich H., Vazquez F., Weir BA, Van Allen EM, et al. Nature biotechnology, 2016/04/18, (2016) Read More / View Supplemental Materials
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Circadian gene variants influence sleep and the sleep electroencephalogram in humans.Chang, AM, Bjonnes AC, Aeschbach D., Buxton OM, Gooley JJ, Anderson C., Reen EV, Cain SW, Czeisler CA, Duffy JF, Lockley SW, Shea SA, Scheer FA, and Saxena R. Chronobiology international, 2016/04/18, p.1-13, (2016) Read More / View Supplemental Materials
Abstract
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.Okbay, A., Baselmans BM, De Neve JE, Turley P., Nivard MG, Fontana MA, Meddens SF, Linnér RK, Rietveld CA, Derringer J., Gratten J., Lee JJ, Liu JZ, de Vlaming R., Ahluwalia TS, Buchwald J., Cavadino A., Frazier-Wood AC, Furlotte NA, Garfield V., et al. Nature genetics, 2016/04/18, (2016) Read More / View Supplemental Materials
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Physical and neurobehavioral determinants of reproductive onset and success.Day, FR, Helgason H., Chasman DI, Rose LM, Loh PR, Scott RA, Helgason A., Kong A., Masson G., Magnusson OT, Gudbjartsson D., Thorsteinsdottir U., Buring JE, Ridker PM, Sulem P., Stefansson K., Ong KK, and Perry JR Nature genetics, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles.Allegretti, JR, Kearney S., Li N., Bogart E., Bullock K., Gerber GK, Bry L., Clish CB, Alm E., and Korzenik JR Alimentary pharmacology & therapeutics, 2016/04/18, (2016) Read More / View Supplemental Materials
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The reproductive tracts of two malaria vectors are populated by a core microbiome and by gender- and swarm-enriched microbial biomarkers.Segata, N., Baldini F., Pompon J., Garrett WS, Truong DT, Dabiré RK, Diabaté A., Levashina EA, and Catteruccia F. Scientific reports, 2016/04/18, Volume 6, p.24207, (2016) Read More / View Supplemental Materials
Abstract
Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.Reese, TA, Bi K., Kambal A., Filali-Mouhim A., Beura LK, Bürger MC, Pulendran B., Sekaly RP, Jameson SC, Masopust D., Haining WN, and Virgin HW Cell host & microbe, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
Synthetic biology platform technologies for antimicrobial applications.Braff, D., Shis D., and Collins JJ Advanced drug delivery reviews, 2016/04/18, (2016) Read More / View Supplemental Materials
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Applications in image-based profiling of perturbations.Caicedo, JC, Singh S., and Carpenter AE Current opinion in biotechnology, 2016/04/15, Volume 39, p.134-142, (2016) Read More / View Supplemental Materials
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Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes.Flannick, J., Johansson S., and Njølstad PR Nature reviews. Endocrinology, 2016/04/15, (2016) Read More / View Supplemental Materials
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Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.Giannakis, M., Mu XJ, Shukla SA, Qian ZR, Cohen O., Nishihara R., Bahl S., Cao Y., Amin-Mansour A., Yamauchi M., Sukawa Y., Stewart C., Rosenberg M., Mima K., Inamura K., Nosho K., Nowak JA, Lawrence MS, Giovannucci EL, Chan AT, et al. Cell reports, 2016/04/14, (2016) Read More / View Supplemental Materials
Abstract
A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface.Ferreira, LM, Meissner TB, Mikkelsen TS, Mallard W., O'Donnell CW, Tilburgs T., Gomes HA, Camahort R., Sherwood RI, Gifford DK, Rinn JL, Cowan CA, and Strominger JL Proceedings of the National Academy of Sciences of the United States of America, 2016/04/13, (2016) Read More / View Supplemental Materials
Abstract
The Human Vaccines Project: A roadmap for cancer vaccine development.Romero, P., Banchereau J., Bhardwaj N., Cockett M., Disis ML, Dranoff G., Gilboa E., Hammond SA, Hershberg R., Korman AJ, Kvistborg P., Melief C., Mellman I., Palucka AK, Redchenko I., Robins H., Sallusto F., Schenkelberg T., Schoenberger S., Sosman J., et al. Science translational medicine, 2016/04/13, Volume 8, Issue 334, p.334ps9, (2016) Read More / View Supplemental Materials
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A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.Bodea, CA, Neale BM, Ripke S., International IBD Genetics Consortium, Daly M. J., Devlin B., and Roeder K. American journal of human genetics, 2016/04/13, (2016) Read More / View Supplemental Materials
Abstract
Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development.Thyme, SB, and Schier AF Cell reports, 2016/04/13, (2016) Read More / View Supplemental Materials
Abstract
Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation.Szaflarski, W., Fay MM, Kedersha N., Zabel M., Anderson P., and Ivanov P. Oncotarget, 2016/04/13, (2016) Read More / View Supplemental Materials
Abstract
Wisteria Floribunda Agglutinin-Labeled Perineuronal Nets in the Mouse Inferior Colliculus, Thalamic Reticular Nucleus and Auditory Cortex.Fader, SM, Imaizumi K., Yanagawa Y., and Lee CC Brain sciences, 2016/04/13, Volume 6, Issue 2, (2016) Read More / View Supplemental Materials
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Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci.Smith, DJ, Escott-Price V., Davies G., Bailey ME, Colodro-Conde L., Ward J., Vedernikov A., Marioni R., Cullen B., Lyall D., Hagenaars SP, Liewald DC, Luciano M., Gale CR, Ritchie SJ, Hayward C., Nicholl B., Bulik-Sullivan B., Adams M., Couvy-Duchesne B., et al. Molecular psychiatry, 2016/04/12, (2016) Read More / View Supplemental Materials
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The statistical properties of gene-set analysis.de Leeuw, CA, Neale BM, Heskes T., and Posthuma D. Nature reviews. Genetics, 2016/04/12, (2016) Read More / View Supplemental Materials
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Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease.Allen, GI, Amoroso N., Anghel C., Balagurusamy V., Bare CJ, Beaton D., Bellotti R., Bennett DA, Boehme K., Boutros PC, Caberlotto L., Caloian C., Campbell F., Neto EC, Chang YC, Chen B., Chen CY, Chien TY, Clark T., Das S., et al. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016/04/11, (2016) Read More / View Supplemental Materials
Abstract
Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance.Desjardins, CA, Cohen KA, Munsamy V., Abeel T., Maharaj K., Walker BJ, Shea TP, Almeida DV, Manson AL, Salazar A., Padayatchi N., O'Donnell MR, Mlisana KP, Wortman J., Birren BW, Grosset J., Earl AM, and Pym AS Nature genetics, 2016/04/11, (2016) Read More / View Supplemental Materials
Abstract
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.Townsend, EC, Murakami MA, Christodoulou A., Christie AL, Köster J., DeSouza TA, Morgan EA, Kallgren SP, Liu H., Wu SC, Plana O., Montero J., Stevenson KE, Rao P., Vadhi R., Andreeff M., Armand P., Ballen KK, Barzaghi-Rinaudo P., Cahill S., et al. Cancer cell, 2016/04/11, Volume 29, Issue 4, p.574-86, (2016) Read More / View Supplemental Materials
Abstract
Superheroes of disease resistance.Macarthur, D. Nature biotechnology, 2016/04/11, (2016) Read More / View Supplemental Materials
The Chthonomonas calidirosea genome is highly conserved across geography and distinct chemical and microbial environments in the Taupō Volcanic Zone, New Zealand.Lee, KC, Stott MB, Dunfield PF, Huttenhower C., McDonald IR, and Morgan XC Applied and environmental microbiology, 2016/04/08, (2016) Read More / View Supplemental Materials
Abstract
Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio.Titov, DV, Cracan V., Goodman RP, Peng J., Grabarek Z., and Mootha VK Science (New York, N.Y.), 2016/04/08, Volume 352, Issue 6282, p.231-5, (2016) Read More / View Supplemental Materials
Abstract
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.Tirosh, I., Izar B., Prakadan SM, Wadsworth MH 2nd, Treacy D., Trombetta JJ, Rotem A., Rodman C., Lian C., Murphy G., Fallahi-Sichani M., Dutton-Regester K., Lin JR, Cohen O., Shah P., Lu D., Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, et al. Science (New York, N.Y.), 2016/04/08, Volume 352, Issue 6282, p.189-96, (2016) Read More / View Supplemental Materials
Abstract
High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria.Swann, J., Corey V., Scherer CA, Kato N., Comer E., Maetani M., Antonova-Koch Y., Reimer C., Gagaring K., Ibanez M., Plouffe D., Zeeman AM, Kocken CH, McNamara CW, Schreiber SL, Campo B., Winzeler EA, and Meister S. ACS infectious diseases, 2016/04/08, Volume 2, Issue 4, p.281-293, (2016) Read More / View Supplemental Materials
Abstract
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.Gusev, A., Shi H., Kichaev G., Pomerantz M., Li F., Long HW, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B., Isaacs WB, Zheng W., Pettaway CA, Yeboah ED, Tettey Y., Biritwum RB, Adjei AA, Tay E., Truelove A., et al. Nature communications, 2016/04/07, Volume 7, p.10979, (2016) Read More / View Supplemental Materials
Abstract
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.Puram, RV, Kowalczyk MS, de Boer CG, Schneider RK, Miller PG, McConkey M., Tothova Z., Tejero H., Heckl D., Järås M., Chen MC, Li H., Tamayo A., Cowley GS, Rozenblatt-Rosen O., Al-Shahrour F., Regev A., and Ebert BL Cell, 2016/04/07, Volume 165, Issue 2, p.303-16, (2016) Read More / View Supplemental Materials
Abstract
Polymorphic tandem repeats within gene promoters act as modifiers of gene expression and DNA methylation in humans.Quilez, J., Guilmatre A., Garg P., Highnam G., Gymrek M., Erlich Y., Joshi RS, Mittelman D., and Sharp AJ Nucleic acids research, 2016/04/07, (2016) Read More / View Supplemental Materials
Abstract
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