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2010
Small-molecule inducers of insulin expression in pancreatic alpha-cells.Fomina-Yadlin, D., Kubicek S., Walpita D., Dancik V., Hecksher-Sørensen J., Bittker JA, Sharifnia T., Shamji A., Clemons PA, Wagner BK, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2010/08/24, Volume 107, Issue 34, p.15099-104, (2010) Read More / View Supplemental Materials
Abstract
Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.Chou, DH, Bodycombe NE, Carrinski HA, Lewis TA, Clemons PA, Schreiber SL, and Wagner BK ACS chemical biology, 2010/08/20, Volume 5, Issue 8, p.729-34, (2010) Read More / View Supplemental Materials
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Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.Segrè, AV, DIAGRAM Consortium, investigators MAGIC, Groop L., Mootha VK, Daly M. J., and Altshuler D. PLoS genetics, 2010/08/12, Volume 6, Issue 8, (2010) Read More / View Supplemental Materials
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MicroRNA miR-125a controls hematopoietic stem cell number.Guo, S., Lu J., Schlanger R., Zhang H., Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B., Merkenschlager M., Golub T. R., and Scadden DT Proceedings of the National Academy of Sciences of the United States of America, 2010/08/10, Volume 107, Issue 32, p.14229-34, (2010) Read More / View Supplemental Materials
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A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.Huarte, M., Guttman M., Feldser D., Garber M., Koziol MJ, Kenzelmann-Broz D., Khalil AM, Zuk O., Amit I., Rabani M., Attardi LD, Regev A., Lander E. S., Jacks T., and Rinn JL Cell, 2010/08/06, Volume 142, Issue 3, p.409-19, (2010) Read More / View Supplemental Materials
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Points of view: Color coding.Wong, B. Nature methods, 2010/08/01, Volume 7, Issue 8, p.573, (2010) Read More / View Supplemental Materials
Screening cellular feature measurements for image-based assay development.Logan, DJ, and Carpenter AE Journal of biomolecular screening, 2010/08/01, Volume 15, Issue 7, p.840-6, (2010) Read More / View Supplemental Materials
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Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.Barretina, J., Taylor BS, Banerji S., Ramos AH, Lagos-Quintana M., Decarolis PL, Shah K., Socci ND, Weir BA, Ho A., Chiang DY, Reva B., Mermel CH, Getz G., Antipin Y., Beroukhim R., Major JE, Hatton C., Nicoletti R., Hanna M., et al. Nature genetics, 2010/08/01, Volume 42, Issue 8, p.715-21, (2010) Read More / View Supplemental Materials
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Activation of a metabolic gene regulatory network downstream of mTOR complex 1.Düvel, K., Yecies JL, Menon S., Raman P., Lipovsky AI, Souza AL, Triantafellow E., Ma Q., Gorski R., Cleaver S., Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, and Manning BD Molecular cell, 2010/07/30, Volume 39, Issue 2, p.171-83, (2010) Read More / View Supplemental Materials
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Whole proteomes as internal standards in quantitative proteomics.Ong, SE Genome medicine, 2010/07/30, Volume 2, Issue 7, p.49, (2010) Read More / View Supplemental Materials
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Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia.Vu, TT, Holmes EC, Duong V., Nguyen TQ, Tran TH, Quail M., Churcher C., Parkhill J., Cardosa J., Farrar J., Wills B., Lennon NJ, Birren BW, Buchy P., Henn MR, and Simmons CP PLoS neglected tropical diseases, 2010/07/20, Volume 4, Issue 7, p.e757, (2010) Read More / View Supplemental Materials
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Distinct biological network properties between the targets of natural products and disease genes.Dancík, V., Seiler KP, Young DW, Schreiber SL, and Clemons PA Journal of the American Chemical Society, 2010/07/14, Volume 132, Issue 27, p.9259-61, (2010) Read More / View Supplemental Materials
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Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Bradner, JE, Mak R., Tanguturi SK, Mazitschek R., Haggarty SJ, Ross K., Chang CY, Bosco J., West N., Morse E., Lin K., Shen JP, Kwiatkowski NP, Gheldof N., Dekker J., DeAngelo DJ, Carr SA, Schreiber SL, Golub T. R., and Ebert BL Proceedings of the National Academy of Sciences of the United States of America, 2010/07/13, Volume 107, Issue 28, p.12617-22, (2010) Read More / View Supplemental Materials
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Curve-based multivariate distance matrix regression analysis: application to genetic association analyses involving repeated measures.Salem, RM, O'Connor DT, and Schork NJ Physiological genomics, 2010/07/07, Volume 42, Issue 2, p.236-47, (2010) Read More / View Supplemental Materials
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The role of nucleosome positioning in the evolution of gene regulation.Tsankov, AM, Thompson DA, Socha A., Regev A., and Rando OJ PLoS biology, 2010/07/06, Volume 8, Issue 7, p.e1000414, (2010) Read More / View Supplemental Materials
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Cardiac Arrhythmia: In vivo screening in the zebrafish to overcome complexity in drug discovery.Macrae, CA Expert opinion on drug discovery, 2010/07/01, Volume 5, Issue 7, p.619-632, (2010) Read More / View Supplemental Materials
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New approaches to population stratification in genome-wide association studies.Price, AL, Zaitlen NA, Reich D., and Patterson N. Nature reviews. Genetics, 2010/07/01, Volume 11, Issue 7, p.459-63, (2010) Read More / View Supplemental Materials
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Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control.Neafsey, DE, Barker BM, Sharpton TJ, Stajich JE, Park DJ, Whiston E., Hung CY, McMahan C., White J., Sykes S., Heiman D., Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., FitzGerald M., Lui A., Macdonald JP, et al. Genome research, 2010/07/01, Volume 20, Issue 7, p.938-46, (2010) Read More / View Supplemental Materials
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Targeted exon sequencing by in-solution hybrid selection.Blumenstiel, B., Cibulskis K., Fisher S., DeFelice M., Barry A., Fennell T., Abreu J., Minie B., Costello M., Young G., Maquire J., Kernytsky A., Melnikov A., Rogov P., Gnirke A., and Gabriel S. Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.], 2010/07/01, Volume Chapter 18, p.Unit 18.4, (2010) Read More / View Supplemental Materials
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TB database 2010: overview and update.Galagan, JE, Sisk P., Stolte C., Weiner B., Koehrsen M., Wymore F., Reddy TB, Zucker JD, Engels R., Gellesch M., Hubble J., Jin H., Larson L., Mao M., Nitzberg M., White J., Zachariah ZK, Sherlock G., Ball CA, and Schoolnik GK Tuberculosis (Edinburgh, Scotland), 2010/07/01, Volume 90, Issue 4, p.225-35, (2010) Read More / View Supplemental Materials
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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.Voight, BF, Scott LJ, Steinthorsdottir V., Morris AP, Dina C., Welch RP, Zeggini E., Huth C., Aulchenko YS, Thorleifsson G., McCulloch LJ, Ferreira T., Grallert H., Amin N., Wu G., Willer CJ, Raychaudhuri S., McCarroll SA, Langenberg C., Hofmann OM, et al. Nature genetics, 2010/07/01, Volume 42, Issue 7, p.579-89, (2010) Read More / View Supplemental Materials
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RESOLVING CLUSTERED WORMS VIA PROBABILISTIC SHAPE MODELS.Wählby, C., Riklin-Raviv T., Ljosa V., Conery AL, Golland P., Ausubel FM, and Carpenter AE Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging, 2010/06/21, Volume 2010, Issue 14-17 April 2010, p.552-555, (2010) Read More / View Supplemental Materials
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Stereochemical and skeletal diversity arising from amino propargylic alcohols.Pizzirani, D., Kaya T., Clemons PA, and Schreiber SL Organic letters, 2010/06/18, Volume 12, Issue 12, p.2822-5, (2010) Read More / View Supplemental Materials
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Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network.Aiden, AP, Rivera MN, Rheinbay E., Ku M., Coffman EJ, Truong TT, Vargas SO, Lander E. S., Haber DA, and Bernstein BE Cell stem cell, 2010/06/04, Volume 6, Issue 6, p.591-602, (2010) Read More / View Supplemental Materials
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Candidate gene association resource (CARe): design, methods, and proof of concept.Musunuru, K., Lettre G., Young T., Farlow DN, Pirruccello JP, Ejebe KG, Keating BJ, Yang Q., Chen MH, Lapchyk N., Crenshaw A., Ziaugra L., Rachupka A., Benjamin EJ, Cupples LA, Fornage M., Fox ER, Heckbert SR, Hirschhorn JN, Newton-Cheh C., et al. Circulation. Cardiovascular genetics, 2010/06/01, Volume 3, Issue 3, p.267-75, (2010) Read More / View Supplemental Materials
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Cell-based assays for high-throughput screening.An, WF, and Tolliday N. Molecular biotechnology, 2010/06/01, Volume 45, Issue 2, p.180-6, (2010) Read More / View Supplemental Materials
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Cheminformatics approaches to analyze diversity in compound screening libraries.Akella, LB, and DeCaprio D. Current opinion in chemical biology, 2010/06/01, Volume 14, Issue 3, p.325-30, (2010) Read More / View Supplemental Materials
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A complex task? Direct modulation of transcription factors with small molecules.Koehler, AN Current opinion in chemical biology, 2010/06/01, Volume 14, Issue 3, p.331-40, (2010) Read More / View Supplemental Materials
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Current strategies for diversity-oriented synthesis.Dandapani, S., and Marcaurelle LA Current opinion in chemical biology, 2010/06/01, Volume 14, Issue 3, p.362-70, (2010) Read More / View Supplemental Materials
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Metabolite profiling identifies markers of uremia.Rhee, EP, Souza A., Farrell L., Pollak MR, Lewis GD, Steele DJ, Thadhani R., Clish CB, Greka A., and Gerszten RE Journal of the American Society of Nephrology : JASN, 2010/06/01, Volume 21, Issue 6, p.1041-1051, (2010) Read More / View Supplemental Materials
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Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.Boulbes, D., Chen CH, Shaikenov T., Agarwal NK, Peterson TR, Addona TA, Keshishian H., Carr SA, Magnuson MA, Sabatini DM, and Sarbassov dos D. Molecular cancer research : MCR, 2010/06/01, Volume 8, Issue 6, p.896-906, (2010) Read More / View Supplemental Materials
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Metabolic signatures of exercise in human plasma.Lewis, GD, Farrell L., Wood MJ, Martinovic M., Arany Z., Rowe GC, Souza A., Cheng S., McCabe EL, Yang E., Shi X., Deo R., Roth FP, Asnani A., Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, et al. Science translational medicine, 2010/05/26, Volume 2, Issue 33, p.33ra37, (2010) Read More / View Supplemental Materials
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A catalog of reference genomes from the human microbiome.Human Microbiome Jumpstart Reference Strains, Consortium, Nelson KE, Weinstock GM, Highlander SK, Worley KC, Creasy HH, Wortman JR, Rusch DB, Mitreva M., Sodergren E., Chinwalla AT, Feldgarden M., Gevers D., Haas BJ, Madupu R., Ward DV, Birren BW, Gibbs RA, Methe B., Petrosino JF, et al. Science (New York, N.Y.), 2010/05/21, Volume 328, Issue 5981, p.994-9, (2010) Read More / View Supplemental Materials
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Vibrio chromosomes share common history.Kirkup BC, Jr, Chang L., Chang S., Gevers D., and Polz MF BMC microbiology, 2010/05/10, Volume 10, p.137, (2010) Read More / View Supplemental Materials
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A draft sequence of the Neandertal genome.Green, RE, Krause J., Briggs AW, Maricic T., Stenzel U., Kircher M., Patterson N., Li H., Zhai W., Fritz MH, Hansen NF, Durand EY, Malaspinas AS, Jensen JD, Marques-Bonet T., Alkan C., Prüfer K., Meyer M., Burbano HA, Good JM, et al. Science (New York, N.Y.), 2010/05/07, Volume 328, Issue 5979, p.710-22, (2010) Read More / View Supplemental Materials
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Hi-C: a method to study the three-dimensional architecture of genomes.van Berkum, NL, Lieberman-Aiden E., Williams L., Imakaev M., Gnirke A., Mirny LA, Dekker J., and Lander E. S. Journal of visualized experiments : JoVE, 2010/05/06, Issue 39, (2010) Read More / View Supplemental Materials
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Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs.Guttman, M., Garber M., Levin JZ, Donaghey J., Robinson J., Adiconis X., Fan L., Koziol MJ, Gnirke A., Nusbaum C., Rinn JL, Lander E. S., and Regev A. Nature biotechnology, 2010/05/01, Volume 28, Issue 5, p.503-10, (2010) Read More / View Supplemental Materials
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Dynamic single-cell imaging of direct reprogramming reveals an early specifying event.Smith, ZD, Nachman I., Regev A., and Meissner A. Nature biotechnology, 2010/05/01, Volume 28, Issue 5, p.521-6, (2010) Read More / View Supplemental Materials
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Genome-wide synteny through highly sensitive sequence alignment: Satsuma.Grabherr, MG, Russell P., Meyer M., Mauceli E., Alföldi J., Di Palma F., and Lindblad-Toh K. Bioinformatics (Oxford, England), 2010/05/01, Volume 26, Issue 9, p.1145-51, (2010) Read More / View Supplemental Materials
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High-quality draft genome sequences of 28 Enterococcus sp. isolates.Palmer, KL, Carniol K., Manson JM, Heiman D., Shea T., Young S., Zeng Q., Gevers D., Feldgarden M., Birren B., and Gilmore MS Journal of bacteriology, 2010/05/01, Volume 192, Issue 9, p.2469-70, (2010) Read More / View Supplemental Materials
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The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.Zimmer, M., Lamb J., Ebert BL, Lynch M., Neil C., Schmidt E., Golub T. R., and Iliopoulos O. Cancer research, 2010/04/15, Volume 70, Issue 8, p.3071-9, (2010) Read More / View Supplemental Materials
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International network of cancer genome projects.International Cancer Genome, Consortium, Hudson T. J., Anderson W., Artez A., Barker AD, Bell C., Bernabé RR, Bhan MK, Calvo F., Eerola I., Gerhard DS, Guttmacher A., Guyer M., Hemsley FM, Jennings JL, Kerr D., Klatt P., Kolar P., Kusada J., Lane DP, et al. Nature, 2010/04/15, Volume 464, Issue 7291, p.993-8, (2010) Read More / View Supplemental Materials
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Optimizing performance of glycopeptide capture for plasma proteomics.Berven, FS, Ahmad R., Clauser KR, and Carr SA Journal of proteome research, 2010/04/05, Volume 9, Issue 4, p.1706-15, (2010) Read More / View Supplemental Materials
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Counterpoint: Data first.Golub, T. Nature, 2010/04/01, Volume 464, Issue 7289, p.679, (2010) Read More / View Supplemental Materials
Endoplasmic reticulum stress and atherosclerosis.Hotamisligil, GS Nature medicine, 2010/04/01, Volume 16, Issue 4, p.396-9, (2010) Read More / View Supplemental Materials
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Genetic resistance to diet-induced obesity in chromosome substitution strains of mice.Burrage, LC, Baskin-Hill AE, Sinasac DS, Singer JB, Croniger CM, Kirby A., Kulbokas E. J., Daly M. J., Lander E. S., Broman KW, and Nadeau JH Mammalian genome : official journal of the International Mammalian Genome Society, 2010/04/01, Volume 21, Issue 3-4, p.115-29, (2010) Read More / View Supplemental Materials
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Integrative analysis of the melanoma transcriptome.Berger, MF, Levin JZ, Vijayendran K., Sivachenko A., Adiconis X., Maguire J., Johnson LA, Robinson J., Verhaak RG, Sougnez C., Onofrio RC, Ziaugra L., Cibulskis K., Laine E., Barretina J., Winckler W., Fisher DE, Getz G., Meyerson M., Jaffe DB, et al. Genome research, 2010/04/01, Volume 20, Issue 4, p.413-27, (2010) Read More / View Supplemental Materials
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Screen for RAS-Selective Lethal Compounds and VDAC LigandsBittker, JA, Weiwer M., Shimada K., Yang WS, Macpherson L., Dandapani S., Munoz B., Palmer M., Stockwell BR, and Schreiber SL, 2010/03/26, (2010) Read More / View Supplemental Materials
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Systematic discovery of regulatory motifs in Fusarium graminearum by comparing four Fusarium genomes.Kumar, L., Breakspear A., Kistler C., Ma LJ, and Xie X. BMC genomics, 2010/03/26, Volume 11, p.208, (2010) Read More / View Supplemental Materials
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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.Hotamisligil, GS Cell, 2010/03/19, Volume 140, Issue 6, p.900-17, (2010) Read More / View Supplemental Materials
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Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.Ma, LJ, van der Does HC, Borkovich KA, Coleman JJ, Daboussi MJ, Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B., Houterman PM, Kang S., Shim WB, Woloshuk C., Xie X., Xu JR, Antoniw J., Baker SE, Bluhm BH, Breakspear A., et al. Nature, 2010/03/18, Volume 464, Issue 7287, p.367-73, (2010) Read More / View Supplemental Materials
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Molecular sampling of prostate cancer: a dilemma for predicting disease progression.Sboner, A., Demichelis F., Calza S., Pawitan Y., Setlur SR, Hoshida Y., Perner S., Adami HO, Fall K., Mucci LA, Kantoff PW, Stampfer M., Andersson SO, Varenhorst E., Johansson JE, Gerstein MB, Golub T. R., Rubin MA, and Andrén O. BMC medical genomics, 2010/03/16, Volume 3, p.8, (2010) Read More / View Supplemental Materials
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Blood pressure and human genetic variation in the general population.Arora, P., and Newton-Cheh C. Current opinion in cardiology, 2010/03/10, (2010) Read More / View Supplemental Materials
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Carbon metabolism-mediated myogenic differentiation.Bracha, AL, Ramanathan A., Huang S., Ingber DE, and Schreiber SL Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.202-204, (2010) Read More / View Supplemental Materials
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Chemical phylogenetics of histone deacetylases.Bradner, JE, West N., Grachan ML, Greenberg EF, Haggarty SJ, Warnow T., and Mazitschek R. Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.238-243, (2010) Read More / View Supplemental Materials
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Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke.Jimenez-Conde, J., Biffi A., Rahman R., Kanakis A., Butler C., Sonni S., Massasa E., Cloonan L., Gilson A., Capozzo K., Cortellini L., Ois A., Cuadrado-Godia E., Rodriguez-Campello A., Furie KL, Roquer J., Rosand J., and Rost NS Stroke; a journal of cerebral circulation, 2010/03/01, Volume 41, Issue 3, p.437-42, (2010) Read More / View Supplemental Materials
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Mining regulatory 5'UTRs from cDNA deep sequencing datasets.Livny, J., and Waldor MK Nucleic acids research, 2010/03/01, Volume 38, Issue 5, p.1504-14, (2010) Read More / View Supplemental Materials
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Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.Gohil, VM, Sheth SA, Nilsson R., Wojtovich AP, Lee JH, Perocchi F., Chen W., Clish CB, and Mootha VK Nature biotechnology, 2010/03/01, Volume 28, Issue 3, p.249-55, (2010) Read More / View Supplemental Materials
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Rapid behavior-based identification of neuroactive small molecules in the zebrafish.Kokel, D., Bryan J., Laggner C., White R., Cheung CY, Mateus R., Healey D., Kim S., Werdich AA, Haggarty SJ, Macrae CA, Shoichet B., and Peterson RT Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.231-237, (2010) Read More / View Supplemental Materials
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Synthetic chemistry: An upfront investment.Young, DW Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.174-175, (2010) Read More / View Supplemental Materials
Unbiased identification of protein-bait interactions using biochemical enrichment and quantitative proteomics.Ong, SE Cold Spring Harbor protocols, 2010/03/01, Volume 2010, Issue 3, p.pdb.prot5400, (2010) Read More / View Supplemental Materials
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The landscape of somatic copy-number alteration across human cancers.Beroukhim, R., Mermel CH, Porter D., Wei G., Raychaudhuri S., Donovan J., Barretina J., Boehm JS, Dobson J., Urashima M., Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L., Greulich H., Reich M., Winckler W., Lawrence MS, Weir BA, et al. Nature, 2010/02/18, Volume 463, Issue 7283, p.899-905, (2010) Read More / View Supplemental Materials
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A composite of multiple signals distinguishes causal variants in regions of positive selection.Grossman, SR, Shylakhter I., Karlsson EK, Byrne EH, Morales S., Frieden G., Hostetter E., Angelino E., Garber M., Zuk O., Lander E. S., Schaffner SF, and Sabeti PC Science (New York, N.Y.), 2010/02/12, Volume 327, Issue 5967, p.883-6, (2010) Read More / View Supplemental Materials
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The fast track to multidrug resistance.Kaufmann, BB, and Hung DT Molecular cell, 2010/02/12, Volume 37, Issue 3, p.297-8, (2010) Read More / View Supplemental Materials
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Analysis of high-throughput sequencing and annotation strategies for phage genomes.Henn, MR, Sullivan MB, Stange-Thomann N., Osburne MS, Berlin AM, Kelly L., Yandava C., Kodira C., Zeng Q., Weiand M., Sparrow T., Saif S., Giannoukos G., Young SK, Nusbaum C., Birren BW, and Chisholm SW PloS one, 2010/02/05, Volume 5, Issue 2, p.e9083, (2010) Read More / View Supplemental Materials
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Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry.Tabb, DL, Vega-Montoto L., Rudnick PA, Variyath AM, Ham AJ, Bunk DM, Kilpatrick LE, Billheimer DD, Blackman RK, Cardasis HL, Carr SA, Clauser KR, Jaffe JD, Kowalski KA, Neubert TA, Regnier FE, Schilling B., Tegeler TJ, Wang M., Wang P., et al. Journal of proteome research, 2010/02/05, Volume 9, Issue 2, p.761-76, (2010) Read More / View Supplemental Materials
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Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast.Radman-Livaja, M., Liu CL, Friedman N., Schreiber SL, and Rando OJ PLoS genetics, 2010/02/05, Volume 6, Issue 2, p.e1000837, (2010) Read More / View Supplemental Materials
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A scalable, fully automated process for construction of sequence-ready barcoded libraries for 454.Lennon, NJ, Lintner RE, Anderson S., Alvarez P., Barry A., Brockman W., Daza R., Erlich RL, Giannoukos G., Green L., Hollinger A., Hoover CA, Jaffe DB, Juhn F., McCarthy D., Perrin D., Ponchner K., Powers TL, Rizzolo K., Robbins D., et al. Genome biology, 2010/02/05, Volume 11, Issue 2, p.R15, (2010) Read More / View Supplemental Materials
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Analytical validation of protein-based multiplex assays: a workshop report by the NCI-FDA interagency oncology task force on molecular diagnostics.Rodriguez, H., Tezak Z., Mesri M., Carr SA, Liebler DC, Fisher SJ, Tempst P., Hiltke T., Kessler LG, Kinsinger CR, Philip R., Ransohoff DF, Skates SJ, Regnier FE, Anderson NL, Mansfield E., and Workshop Participants Clinical chemistry, 2010/02/01, Volume 56, Issue 2, p.237-43, (2010) Read More / View Supplemental Materials
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Automated detection of inaccurate and imprecise transitions in peptide quantification by multiple reaction monitoring mass spectrometry.Abbatiello, SE, Mani D. R., Keshishian H., and Carr SA Clinical chemistry, 2010/02/01, Volume 56, Issue 2, p.291-305, (2010) Read More / View Supplemental Materials
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CK1epsilon is required for breast cancers dependent on beta-catenin activity.Kim, SY, Dunn IF, Firestein R., Gupta P., Wardwell L., Repich K., Schinzel AC, Wittner B., Silver SJ, Root DE, Boehm JS, Ramaswamy S., Lander E. S., and Hahn WC PloS one, 2010/02/01, Volume 5, Issue 2, p.e8979, (2010) Read More / View Supplemental Materials
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Genetic structure of a unique admixed population: implications for medical research.Patterson, N., Petersen DC, van der Ross RE, Sudoyo H., Glashoff RH, Marzuki S., Reich D., and Hayes VM Human molecular genetics, 2010/02/01, Volume 19, Issue 3, p.411-9, (2010) Read More / View Supplemental Materials
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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.Saxena, R., Hivert MF, Langenberg C., Tanaka T., Pankow JS, Vollenweider P., Lyssenko V., Bouatia-Naji N., Dupuis J., Jackson AU, Kao WH, Li M., Glazer NL, Manning AK, Luan J., Stringham HM, Prokopenko I., Johnson T., Grarup N., Boesgaard TW, et al. Nature genetics, 2010/02/01, Volume 42, Issue 2, p.142-8, (2010) Read More / View Supplemental Materials
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Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution.Gu, H., Bock C., Mikkelsen TS, Jäger N., Smith ZD, Tomazou E., Gnirke A., Lander E. S., and Meissner A. Nature methods, 2010/02/01, Volume 7, Issue 2, p.133-6, (2010) Read More / View Supplemental Materials
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Integration of proteomic-based tools for improved biomarkers of myocardial injury.Gerszten, RE, Carr SA, and Sabatine M. Clinical chemistry, 2010/02/01, Volume 56, Issue 2, p.194-201, (2010) Read More / View Supplemental Materials
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Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance.Paulovich, AG, Billheimer D., Ham AJ, Vega-Montoto L., Rudnick PA, Tabb DL, Wang P., Blackman RK, Bunk DM, Cardasis HL, Clauser KR, Kinsinger CR, Schilling B., Tegeler TJ, Variyath AM, Wang M., Whiteaker JR, Zimmerman LJ, Fenyo D., Carr SA, et al. Molecular & cellular proteomics : MCP, 2010/02/01, Volume 9, Issue 2, p.242-54, (2010) Read More / View Supplemental Materials
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Introduction: Advances in protein analysis for the clinical laboratory.Hortin, GL, Carr SA, and Anderson NL Clinical chemistry, 2010/02/01, Volume 56, Issue 2, p.149-51, (2010) Read More / View Supplemental Materials
Molecular classification and novel targets in hepatocellular carcinoma: recent advancements.Hoshida, Y., Toffanin S., Lachenmayer A., Villanueva A., Minguez B., and Llovet JM Seminars in liver disease, 2010/02/01, Volume 30, Issue 1, p.35-51, (2010) Read More / View Supplemental Materials
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Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses.Rudnick, PA, Clauser KR, Kilpatrick LE, Tchekhovskoi DV, Neta P., Blonder N., Billheimer DD, Blackman RK, Bunk DM, Cardasis HL, Ham AJ, Jaffe JD, Kinsinger CR, Mesri M., Neubert TA, Schilling B., Tabb DL, Tegeler TJ, Vega-Montoto L., Variyath AM, et al. Molecular & cellular proteomics : MCP, 2010/02/01, Volume 9, Issue 2, p.225-41, (2010) Read More / View Supplemental Materials
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Protein-based multiplex assays: mock presubmissions to the US Food and Drug Administration.Regnier, FE, Skates SJ, Mesri M., Rodriguez H., Tezak Z., Kondratovich MV, Alterman MA, Levin JD, Roscoe D., Reilly E., Callaghan J., Kelm K., Brown D., Philip R., Carr SA, Liebler DC, Fisher SJ, Tempst P., Hiltke T., Kessler LG, et al. Clinical chemistry, 2010/02/01, Volume 56, Issue 2, p.165-71, (2010) Read More / View Supplemental Materials
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Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling.Kuai, L., Wang X., Madison JM, Schreiber SL, Scolnick EM, and Haggarty SJ ACS chemical neuroscience, 2010/01/28, Volume 1, Issue 4, p.325-342, (2010) Read More / View Supplemental Materials
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A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.van Vugt, MA, Gardino AK, Linding R., Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H., Keezer SM, Li J., Pawson T., Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, and Yaffe MB PLoS biology, 2010/01/26, Volume 8, Issue 1, p.e1000287, (2010) Read More / View Supplemental Materials
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A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells.Shaham, O., Xu Q., Ramanathan A., Souza AL, Clish CB, and Mootha VK Proceedings of the National Academy of Sciences of the United States of America, 2010/01/26, Volume 107, Issue 4, p.1571-5, (2010) Read More / View Supplemental Materials
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Computer science. Accessible reproducible research.Mesirov, J. P. Science (New York, N.Y.), 2010/01/22, Volume 327, Issue 5964, p.415-6, (2010) Read More / View Supplemental Materials
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.Clish, CB, Iliopoulos O., and Weissleder R. Cell, 2010/01/22, Volume 140, Issue 2, p.280-93, (2010) Read More / View Supplemental Materials
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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.Verhaak, RG, Hoadley KA, Purdom E., Wang V., Qi Y., Wilkerson MD, Miller CR, Ding L., Golub T., Mesirov J. P., Alexe G., Lawrence M., O'Kelly M., Tamayo P., Weir BA, Gabriel S., Winckler W., Gupta S., Jakkula L., Feiler HS, et al. Cancer cell, 2010/01/19, Volume 17, Issue 1, p.98-110, (2010) Read More / View Supplemental Materials
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Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus.Fan, J., Ionita-Laza I., McQueen MB, Devlin B., Purcell S., Faraone SV, Allen MH, Bowden CL, Calabrese JR, Fossey MD, Friedman ES, Gyulai L., Hauser P., Ketter TB, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel JK, Sachs GS, Thase ME, et al. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010/01/05, Volume 153B, Issue 1, p.29-37, (2010) Read More / View Supplemental Materials
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Antiplasmodial activity of piperazine sulfonamides.Martyn, DC, Cortese JF, Tyndall E., Dick J., Mazitschek R., Munoz B., and Clardy J. Bioorganic & medicinal chemistry letters, 2010/01/01, Volume 20, Issue 1, p.218-21, (2010) Read More / View Supplemental Materials
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Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles.Tassa, C., Duffner JL, Lewis TA, Weissleder R., Schreiber SL, Koehler AN, and Shaw SY Bioconjugate chemistry, 2010/01/01, Volume 21, Issue 1, p.14-9, (2010) Read More / View Supplemental Materials
Abstract
Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA.Goren, A., Ozsolak F., Shoresh N., Ku M., Adli M., Hart C., Gymrek M., Zuk O., Regev A., Milos PM, and Bernstein BE Nature methods, 2010/01/01, Volume 7, Issue 1, p.47-9, (2010) Read More / View Supplemental Materials
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Detecting protein-small molecule interactions using fluorous small-molecule microarrays.Vegas, AJ, and Koehler AN Methods in molecular biology (Clifton, N.J.), 2010/01/01, Volume 669, p.43-55, (2010) Read More / View Supplemental Materials
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Discovery of Inhibitors of Anti-Apoptotic Protein A1Bittker, JA, Weiwer M., Wei G., Germain A., Brown E., Dandapani S., Munoz B., Palmer M., Golub T., and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
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Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2Hartland, CL, Youngsaye W., Morgan B., Ting A., Nag P., Buhrlage S., Johnston S., Bittker J., Vincent B., Whitesell L., Dandapani S., Macpherson L., Munoz B., Palmer M., Lindquist S., and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
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Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3Hartland, CL, Youngsaye W., Dockendorff C., Johnston S., Bittker J., Vincent B., Whitesell L., Dandapani S., Macpherson L., Munoz B., Palmer M., Lindquist S., and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
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ML238: An Antimalarial Small Molecule of a Unique Structural ClassWeiwer, M., Mulrooney C., Massi D., Heidebrecht R., Wiegand R., Lukens AK, Dick J., Wirth D., Ekland E., Cheng CC, Zhao J., Yuan J., Su XZ, Johnson RL, Guha R., Dandapani S., Munoz B., Palmer M., Thomas C., Austin CP, et al., 2010/01/01, (2010) Read More / View Supplemental Materials
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Reconstructing gene histories in Ascomycota fungi.Wapinski, I., and Regev A. Methods in enzymology, 2010/01/01, Volume 470, p.447-85, (2010) Read More / View Supplemental Materials
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Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2Bittker, JA, Weiwer M., Lewis T., Shimada K., Yang WS, Macpherson L., Dandapani S., Munoz B., Palmer M., Stockwell BR, and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
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Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines.Martyn, DC, Nijjar A., Celatka CA, Mazitschek R., Cortese JF, Tyndall E., Liu H., Fitzgerald MM, O'Shea TJ, Danthi S., and Clardy J. Bioorganic & medicinal chemistry letters, 2010/01/01, Volume 20, Issue 1, p.228-31, (2010) Read More / View Supplemental Materials
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Understanding gene sequence variation in the context of transcription regulation in yeast.Gat-Viks, I., Meller R., Kupiec M., and Shamir R. PLoS genetics, 2010/01/01, Volume 6, Issue 1, p.e1000800, (2010) Read More / View Supplemental Materials
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2009
Direct control of mitochondrial function by mTOR.Ramanathan, A., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2009/12/29, Volume 106, Issue 52, p.22229-32, (2009) Read More / View Supplemental Materials
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