Scientific Publications

Search by Keyword(s)
Found 1927 results

Search Results

2011
ContEst: estimating cross-contamination of human samples in next-generation sequencing data.Cibulskis, K., McKenna A., Fennell T., Banks E., DePristo M., and Getz G. Bioinformatics (Oxford, England), 2011/09/15, Volume 27, Issue 18, p.2601-2, (2011) Read More / View Supplemental Materials
Abstract
The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells.Wilson, AJ, Holson E., Wagner F., Zhang YL, Fass DM, Haggarty SJ, Bhaskara S., Hiebert SW, Schreiber SL, and Khabele D. Cancer biology & therapy, 2011/09/15, Volume 12, Issue 6, p.484-93, (2011) Read More / View Supplemental Materials
Abstract
The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment.Sczesnak, A., Segata N., Qin X., Gevers D., Petrosino JF, Huttenhower C., Littman DR, and Ivanov II Cell host & microbe, 2011/09/15, Volume 10, Issue 3, p.260-72, (2011) Read More / View Supplemental Materials
Abstract
Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses.Cabili, MN, Trapnell C., Goff L., Koziol M., Tazon-Vega B., Regev A., and Rinn JL Genes & development, 2011/09/15, Volume 25, Issue 18, p.1915-27, (2011) Read More / View Supplemental Materials
Abstract
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.Youngsaye, W., Vincent B., Hartland CL, Morgan BJ, Buhrlage SJ, Johnston S., Bittker JA, Macpherson L., Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2011/09/15, Volume 21, Issue 18, p.5502-5, (2011) Read More / View Supplemental Materials
Abstract
Computational and statistical approaches to analyzing variants identified by exome sequencing.Stitziel, NO, Kiezun A., and Sunyaev S. Genome biology, 2011/09/14, Volume 12, Issue 9, p.227, (2011) Read More / View Supplemental Materials
Abstract
Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria.Skerlj, RT, Bastos CM, Booker ML, Kramer ML, Barker RH Jr, Celatka CA, O'Shea TJ, Munoz B., Sidhu AB, Cortese JF, Wittlin S., Papastogiannidis P., Angulo-Barturen I., Jimenez-Diaz MB, and Sybertz E. ACS medicinal chemistry letters, 2011/09/08, Volume 2, Issue 9, p.708-13, (2011) Read More / View Supplemental Materials
Abstract
Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis.Chou, DH, Duvall JR, Gerard B., Liu H., Pandya BA, Suh BC, Forbeck EM, Faloon P., Wagner BK, and Marcaurelle LA ACS medicinal chemistry letters, 2011/09/08, Volume 2, Issue 9, p.698-702, (2011) Read More / View Supplemental Materials
Abstract
Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation.Tucker, EJ, Hershman SG, Köhrer C., Belcher-Timme CA, Patel J., Goldberger OA, Christodoulou J., Silberstein JM, McKenzie M., Ryan MT, Compton AG, Jaffe JD, Carr SA, Calvo SE, RajBhandary UL, Thorburn DR, and Mootha VK Cell metabolism, 2011/09/07, Volume 14, Issue 3, p.428-34, (2011) Read More / View Supplemental Materials
Abstract
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.Bass, AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y., Cibulskis K., Sougnez C., Voet D., Saksena G., Sivachenko A., Jing R., Parkin M., Pugh T., Verhaak RG, Stransky N., Boutin AT, Barretina J., Solit DB, Vakiani E., Shao W., et al. Nature genetics, 2011/09/04, Volume 43, Issue 10, p.964-8, (2011) Read More / View Supplemental Materials
Abstract
Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development.Holder, JW, Ulrich JC, DeBono AC, Godfrey PA, Desjardins CA, Zucker J., Zeng Q., Leach AL, Ghiviriga I., Dancel C., Abeel T., Gevers D., Kodira CD, Desany B., Affourtit JP, Birren BW, and Sinskey AJ PLoS genetics, 2011/09/01, Volume 7, Issue 9, p.e1002219, (2011) Read More / View Supplemental Materials
Abstract
Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.Ng, A., and Xavier RJ Autophagy, 2011/09/01, Volume 7, Issue 9, p.1082-4, (2011) Read More / View Supplemental Materials
Abstract
Molecular signatures and prognosis of hepatocellular carcinoma.Hoshida, Y. Minerva gastroenterologica e dietologica, 2011/09/01, Volume 57, Issue 3, p.311-22, (2011) Read More / View Supplemental Materials
Abstract
Points of view: arrows.Wong, B. Nature methods, 2011/09/01, Volume 8, Issue 9, p.701, (2011) Read More / View Supplemental Materials
STK33 kinase activity is nonessential in KRAS-dependent cancer cells.Babij, C., Zhang Y., Kurzeja RJ, Munzli A., Shehabeldin A., Fernando M., Quon K., Kassner PD, Ruefli-Brasse AA, Watson VJ, Fajardo F., Jackson A., Zondlo J., Sun Y., Ellison AR, Plewa CA, San MT, Robinson J., McCarter J., Schwandner R., et al. Cancer research, 2011/09/01, Volume 71, Issue 17, p.5818-26, (2011) Read More / View Supplemental Materials
Abstract
Clustering with position-specific constraints on variance: applying redescending M-estimators to label-free LC-MS data analysis.Frühwirth, R., Mani D. R., and Pyne S. BMC bioinformatics, 2011/08/31, Volume 12, p.358, (2011) Read More / View Supplemental Materials
Abstract
The genome of the green anole lizard and a comparative analysis with birds and mammals.Alföldi, J., Di Palma F., Grabherr M., Williams C., Kong L., Mauceli E., Russell P., Lowe CB, Glor RE, Jaffe JD, Ray DA, Boissinot S., Shedlock AM, Botka C., Castoe TA, Colbourne JK, Fujita MK, Moreno RG, ten Hallers BF, Haussler D., et al. Nature, 2011/08/31, Volume 477, Issue 7366, p.587-91, (2011) Read More / View Supplemental Materials
Abstract
lincRNAs act in the circuitry controlling pluripotency and differentiation.Guttman, M., Donaghey J., Carey BW, Garber M., Grenier JK, Munson G., Young G., Lucas AB, Ach R., Bruhn L., Yang X., Amit I., Meissner A., Regev A., Rinn JL, Root DE, and Lander E. S. Nature, 2011/08/28, Volume 477, Issue 7364, p.295-300, (2011) Read More / View Supplemental Materials
Abstract
Stem cell gene expression programs influence clinical outcome in human leukemia.Eppert, K., Takenaka K., Lechman ER, Waldron L., Nilsson B., van Galen P., Metzeler KH, Poeppl A., Ling V., Beyene J., Canty AJ, Danska JS, Bohlander SK, Buske C., Minden MD, Golub T. R., Jurisica I., Ebert BL, and Dick JE Nature medicine, 2011/08/28, Volume 17, Issue 9, p.1086-93, (2011) Read More / View Supplemental Materials
Abstract
The mutational landscape of head and neck squamous cell carcinoma.Stransky, N., Egloff AM, Tward AD, Kostic AD, Cibulskis K., Sivachenko A., Kryukov GV, Lawrence MS, Sougnez C., McKenna A., Shefler E., Ramos AH, Stojanov P., Carter SL, Voet D., Cortés ML, Auclair D., Berger MF, Saksena G., Guiducci C., et al. Science (New York, N.Y.), 2011/08/26, Volume 333, Issue 6046, p.1157-60, (2011) Read More / View Supplemental Materials
Abstract
Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions.Pandya, BA, Dandapani S., Duvall JR, Rowley A., Mulrooney CA, Ryba T., Dombrowski M., Harton M., Young DW, and Marcaurelle LA Tetrahedron, 2011/08/26, Volume 67, Issue 34, p.6131-6137, (2011) Read More / View Supplemental Materials
Abstract
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells.Gupta, PB, Fillmore CM, Jiang G., Shapira SD, Tao K., Kuperwasser C., and Lander E. S. Cell, 2011/08/19, Volume 146, Issue 4, p.633-44, (2011) Read More / View Supplemental Materials
Abstract
Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase.Peng, LF, Schaefer EA, Maloof N., Skaff A., Berical A., Belon CA, Heck JA, Lin W., Frick DN, Allen TM, Miziorko HM, Schreiber SL, and Chung RT The Journal of infectious diseases, 2011/08/15, Volume 204, Issue 4, p.609-16, (2011) Read More / View Supplemental Materials
Abstract
Molecular evolution of West Nile virus in a northern temperate region: Connecticut, USA 1999-2008.Armstrong, PM, Vossbrinck CR, Andreadis TG, Anderson JF, Pesko KN, Newman RM, Lennon NJ, Birren BW, Ebel GD, and Henn MR Virology, 2011/08/15, Volume 417, Issue 1, p.203-10, (2011) Read More / View Supplemental Materials
Abstract
Hybrid selection for sequencing pathogen genomes from clinical samples.Melnikov, A., Galinsky K., Rogov P., Fennell T., Van Tyne D., Russ C., Daniels R., Barnes KG, Bochicchio J., Ndiaye D., Sene PD, Wirth DF, Nusbaum C., Volkman SK, Birren BW, Gnirke A., and Neafsey DE Genome biology, 2011/08/11, Volume 12, Issue 8, p.R73, (2011) Read More / View Supplemental Materials
Abstract
Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics.Gerszten, RE, Asnani A., and Carr SA Circulation research, 2011/08/05, Volume 109, Issue 4, p.463-74, (2011) Read More / View Supplemental Materials
Abstract
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling.Wagle, N., Emery C., Berger MF, Davis MJ, Sawyer A., Pochanard P., Kehoe SM, Johannessen CM, Macconaill LE, Hahn WC, Meyerson M., and Garraway LA Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/08/01, Volume 29, Issue 22, p.3085-96, (2011) Read More / View Supplemental Materials
Abstract
Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea.Amselem, J., Cuomo CA, van Kan JA, Viaud M., Benito EP, Couloux A., Coutinho PM, de Vries RP, Dyer PS, Fillinger S., Fournier E., Gout L., Hahn M., Wincker P., Anthouard V., Chen Z., Danchin EG, Dasilva C., Güldener U., Henrissat B., et al. PLoS genetics, 2011/08/01, Volume 7, Issue 8, p.e1002230, (2011) Read More / View Supplemental Materials
Abstract
Quantification of proteins using peptide immunoaffinity enrichment coupled with mass spectrometry.Zhao, L., Whiteaker JR, Pope ME, Kuhn E., Jackson A., Anderson NL, Pearson TW, Carr SA, and Paulovich AG Journal of visualized experiments : JoVE, 2011/07/31, Issue 53, (2011) Read More / View Supplemental Materials
Abstract
AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.Kuai, L., Ong SE, Madison JM, Wang X., Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, and Haggarty SJ Chemistry & biology, 2011/07/29, Volume 18, Issue 7, p.891-906, (2011) Read More / View Supplemental Materials
Abstract
Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity.Yu, M., Romer KA, Nieland TJ, Xu S., Saenz-Vash V., Penman M., Yesilaltay A., Carr SA, and Krieger M. Proceedings of the National Academy of Sciences of the United States of America, 2011/07/26, Volume 108, Issue 30, p.12243-8, (2011) Read More / View Supplemental Materials
Abstract
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.Cheung, HW, Cowley GS, Weir BA, Boehm JS, Rusin S., Scott JA, East A., Ali LD, Lizotte PH, Wong TC, Jiang G., Hsiao J., Mermel CH, Getz G., Barretina J., Gopal S., Tamayo P., Gould J., Tsherniak A., Stransky N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2011/07/26, Volume 108, Issue 30, p.12372-7, (2011) Read More / View Supplemental Materials
Abstract
Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction.Shea, J., Agarwala V., Philippakis AA, Maguire J., Banks E., DePristo M., Thomson B., Guiducci C., Onofrio RC, Kathiresan S., Gabriel S., Burtt NP, Daly M. J., Groop L., Altshuler D., and Myocardial Infarction Genetics Consortium Nature genetics, 2011/07/24, Volume 43, Issue 8, p.801-5, (2011) Read More / View Supplemental Materials
Abstract
Extracellular movement of signaling molecules.Müller, P., and Schier AF Developmental cell, 2011/07/19, Volume 21, Issue 1, p.145-58, (2011) Read More / View Supplemental Materials
Abstract
A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin.Reiling, JH, Clish CB, Carette JE, Varadarajan M., Brummelkamp TR, and Sabatini DM Proceedings of the National Academy of Sciences of the United States of America, 2011/07/19, Volume 108, Issue 29, p.11756-65, (2011) Read More / View Supplemental Materials
Abstract
Humanized mice with ectopic artificial liver tissues.Chen, AA, Thomas DK, Ong LL, Schwartz RE, Golub T. R., and Bhatia SN Proceedings of the National Academy of Sciences of the United States of America, 2011/07/19, Volume 108, Issue 29, p.11842-7, (2011) Read More / View Supplemental Materials
Abstract
A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.Kemp, MM, Wang Q., Fuller JH, West N., Martinez NM, Morse EM, Weïwer M., Schreiber SL, Bradner JE, and Koehler AN Bioorganic & medicinal chemistry letters, 2011/07/15, Volume 21, Issue 14, p.4164-9, (2011) Read More / View Supplemental Materials
Abstract
Selective killing of cancer cells by a small molecule targeting the stress response to ROS.Raj, L., Ide T., Gurkar AU, Foley M., Schenone M., Li X., Tolliday NJ, Golub T. R., Carr SA, Shamji AF, Stern AM, Mandinova A., Schreiber SL, and Lee SW Nature, 2011/07/13, Volume 475, Issue 7355, p.231-4, (2011) Read More / View Supplemental Materials
Abstract
Catalytic Diastereoselective Petasis Reactions.Muncipinto, G., Moquist PN, Schreiber SL, and Schaus SE Angewandte Chemie (International ed. in English), 2011/07/12, (2011) Read More / View Supplemental Materials
QnAs with Eric S. Lander. Interview by Prashant Nair.Lander, E. S. Proceedings of the National Academy of Sciences of the United States of America, 2011/07/12, Volume 108, Issue 28, p.11319, (2011) Read More / View Supplemental Materials
Application of a sparse matrix design strategy to the synthesis of dos libraries.Akella, LB, and Marcaurelle LA ACS combinatorial science, 2011/07/11, Volume 13, Issue 4, p.357-64, (2011) Read More / View Supplemental Materials
Abstract
Synthesis of a stereochemically diverse library of medium-sized lactams and sultams via S(N)Ar cycloetherification.Gerard, B., Duvall JR, Lowe JT, Murillo T., Wei J., Akella LB, and Marcaurelle LA ACS combinatorial science, 2011/07/11, Volume 13, Issue 4, p.365-74, (2011) Read More / View Supplemental Materials
Abstract
Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia.Duong, V., Simmons C., Gavotte L., Viari A., Ong S., Chantha N., Lennon NJ, Birren BW, Vong S., Farrar JJ, Henn MR, Deubel V., Frutos R., and Buchy P. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2011/07/02, (2011) Read More / View Supplemental Materials
Abstract
Comparative genomics yields insights into niche adaptation of plant vascular wilt pathogens.Klosterman, SJ, Subbarao KV, Kang S., Veronese P., Gold SE, Thomma BP, Chen Z., Henrissat B., Lee YH, Park J., Garcia-Pedrajas MD, Barbara DJ, Anchieta A., de Jonge R., Santhanam P., Maruthachalam K., Atallah Z., Amyotte SG, Paz Z., Inderbitzin P., et al. PLoS pathogens, 2011/07/01, Volume 7, Issue 7, p.e1002137, (2011) Read More / View Supplemental Materials
Abstract
A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like.Kelly, TJ, Souza AL, Clish CB, and Puigserver P. Molecular and cellular biology, 2011/07/01, Volume 31, Issue 13, p.2696-706, (2011) Read More / View Supplemental Materials
Abstract
Points of view: Avoiding color.Wong, B. Nature methods, 2011/07/01, Volume 8, Issue 7, p.525, (2011) Read More / View Supplemental Materials
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.Fancy, SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C., Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R., Franklin RJ, and Rowitch DH Nature neuroscience, 2011/06/26, Volume 14, Issue 8, p.1009-16, (2011) Read More / View Supplemental Materials
Abstract
A public genome-scale lentiviral expression library of human ORFs.Yang, X., Boehm JS, Yang X., Salehi-Ashtiani K., Hao T., Shen Y., Lubonja R., Thomas SR, Alkan O., Bhimdi T., Green TM, Johannessen CM, Silver SJ, Nguyen C., Murray RR, Hieronymus H., Balcha D., Fan C., Lin C., Ghamsari L., et al. Nature methods, 2011/06/26, Volume 8, Issue 8, p.659-61, (2011) Read More / View Supplemental Materials
Abstract
Metagenomic biomarker discovery and explanation.Segata, N., Izard J., Waldron L., Gevers D., Miropolsky L., Garrett WS, and Huttenhower C. Genome biology, 2011/06/24, Volume 12, Issue 6, p.R60, (2011) Read More / View Supplemental Materials
Abstract
Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.Wang, Y., Jimenez M., Hansen AS, Raiber EA, Schreiber SL, and Young DW Journal of the American Chemical Society, 2011/06/22, Volume 133, Issue 24, p.9196-9, (2011) Read More / View Supplemental Materials
Abstract
A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.Luo, X., Liu Y., Kubicek S., Myllyharju J., Tumber A., Ng S., Che KH, Podoll J., Heightman TD, Oppermann U., Schreiber SL, and Wang X. Journal of the American Chemical Society, 2011/06/22, Volume 133, Issue 24, p.9451-6, (2011) Read More / View Supplemental Materials
Abstract
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.Baughman, JM, Perocchi F., Girgis HS, Plovanich M., Belcher-Timme CA, Sancak Y., Bao XR, Strittmatter L., Goldberger O., Bogorad RL, Koteliansky V., and Mootha VK Nature, 2011/06/19, Volume 476, Issue 7360, p.341-5, (2011) Read More / View Supplemental Materials
Abstract
A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease.Addona, TA, Shi X., Keshishian H., Mani D. R., Burgess M., Gillette MA, Clauser KR, Shen D., Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, and Carr SA Nature biotechnology, 2011/06/19, Volume 29, Issue 7, p.635-43, (2011) Read More / View Supplemental Materials
Abstract
Towards systematic functional characterization of cancer genomes.Boehm, JS, and Hahn WC Nature reviews. Genetics, 2011/06/17, Volume 12, Issue 7, p.487-98, (2011) Read More / View Supplemental Materials
Abstract
Genetics and pathogenesis of inflammatory bowel disease.Khor, B., Gardet A., and Xavier RJ Nature, 2011/06/15, Volume 474, Issue 7351, p.307-17, (2011) Read More / View Supplemental Materials
Abstract
Molecular signatures database (MSigDB) 3.0.Liberzon, A., Subramanian A., Pinchback R., Thorvaldsdóttir H., Tamayo P., and Mesirov J. P. Bioinformatics (Oxford, England), 2011/06/15, Volume 27, Issue 12, p.1739-40, (2011) Read More / View Supplemental Materials
Abstract
mRNA expression signature of Gleason grade predicts lethal prostate cancer.Penney, KL, Sinnott JA, Fall K., Pawitan Y., Hoshida Y., Kraft P., Stark JR, Fiorentino M., Perner S., Finn S., Calza S., Flavin R., Freedman ML, Setlur S., Sesso HD, Andersson SO, Martin N., Kantoff PW, Johansson JE, Adami HO, et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/06/10, Volume 29, Issue 17, p.2391-6, (2011) Read More / View Supplemental Materials
Abstract
Syntheses of α-pyrones using gold-catalyzed coupling reactions.Luo, T., Dai M., Zheng SL, and Schreiber SL Organic letters, 2011/06/03, Volume 13, Issue 11, p.2834-6, (2011) Read More / View Supplemental Materials
Abstract
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.Pan, JQ, Lewis MC, Ketterman JK, Clore EL, Riley M., Richards KR, Berry-Scott E., Liu X., Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, and Haggarty SJ Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011/06/01, Volume 36, Issue 7, p.1397-411, (2011) Read More / View Supplemental Materials
Abstract
Computational methods for transcriptome annotation and quantification using RNA-seq.Garber, M., Grabherr MG, Guttman M., and Trapnell C. Nature methods, 2011/06/01, Volume 8, Issue 6, p.469-77, (2011) Read More / View Supplemental Materials
Abstract
Endemic dengue associated with the co-circulation of multiple viral lineages and localized density-dependent transmission.Raghwani, J., Rambaut A., Holmes EC, Hang VT, Hien TT, Farrar J., Wills B., Lennon NJ, Birren BW, Henn MR, and Simmons CP PLoS pathogens, 2011/06/01, Volume 7, Issue 6, p.e1002064, (2011) Read More / View Supplemental Materials
Abstract
RNA-protein interactions in human health and disease.Khalil, AM, and Rinn JL Seminars in cell & developmental biology, 2011/06/01, Volume 22, Issue 4, p.359-65, (2011) Read More / View Supplemental Materials
Abstract
Summaries from the XVIII World Congress of Psychiatric Genetics, Athens, Greece, 3-7 October 2010.Bergen, SE, Balhara YP, Christoforou A., Cole J., Degenhardt F., Dempster E., Fatjó-Vilas M., Khedr Y., Lopez LM, Lysenko L., McGrath LM, Mühleisen TW, Neves FS, Nymberg C., Ozomaro U., Verweij KJ, Voineskos AN, Zai CC, O'Shea A., and DeLisi LE Psychiatric genetics, 2011/06/01, Volume 21, Issue 3, p.136-72, (2011) Read More / View Supplemental Materials
Abstract
Obligate biotrophy features unraveled by the genomic analysis of rust fungi.Duplessis, S., Cuomo CA, Lin YC, Aerts A., Tisserant E., Veneault-Fourrey C., Joly DL, Hacquard S., Amselem J., Cantarel BL, Chiu R., Coutinho PM, Feau N., Field M., Frey P., Gelhaye E., Goldberg J., Grabherr MG, Kodira CD, Kohler A., et al. Proceedings of the National Academy of Sciences of the United States of America, 2011/05/31, Volume 108, Issue 22, p.9166-71, (2011) Read More / View Supplemental Materials
Abstract
Full-length transcriptome assembly from RNA-Seq data without a reference genome.Grabherr, MG, Haas BJ, Yassour M., Levin JZ, Thompson DA, Amit I., Adiconis X., Fan L., Raychowdhury R., Zeng Q., Chen Z., Mauceli E., Hacohen N., Gnirke A., Rhind N., Di Palma F., Birren BW, Nusbaum C., Lindblad-Toh K., Friedman N., et al. Nature biotechnology, 2011/05/15, Volume 29, Issue 7, p.644-52, (2011) Read More / View Supplemental Materials
Abstract
Mapping and analysis of chromatin state dynamics in nine human cell types.Ernst, J., Kheradpour P., Mikkelsen TS, Shoresh N., Ward LD, Epstein CB, Zhang X., Wang L., Issner R., Coyne M., Ku M., Durham T., Kellis M., and Bernstein BE Nature, 2011/05/05, Volume 473, Issue 7345, p.43-9, (2011) Read More / View Supplemental Materials
Abstract
Discovery of histone deacetylase 8 selective inhibitors.Tang, W., Luo T., Greenberg EF, Bradner JE, and Schreiber SL Bioorganic & medicinal chemistry letters, 2011/05/01, Volume 21, Issue 9, p.2601-5, (2011) Read More / View Supplemental Materials
Abstract
Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis.Zella, GC, Hait EJ, Glavan T., Gevers D., Ward DV, Kitts CL, and Korzenik JR Inflammatory bowel diseases, 2011/05/01, Volume 17, Issue 5, p.1092-100, (2011) Read More / View Supplemental Materials
Abstract
A framework for variation discovery and genotyping using next-generation DNA sequencing data.DePristo, MA, Banks E., Poplin R., Garimella KV, Maguire JR, Hartl C., Philippakis AA, del Angel G., Rivas MA, Hanna M., McKenna A., Fennell TJ, Kernytsky AM, Sivachenko AY, Cibulskis K., Gabriel SB, Altshuler D., and Daly M. J. Nature genetics, 2011/05/01, Volume 43, Issue 5, p.491-8, (2011) Read More / View Supplemental Materials
Abstract
Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells.Rabani, M., Levin JZ, Fan L., Adiconis X., Raychowdhury R., Garber M., Gnirke A., Nusbaum C., Hacohen N., Friedman N., Amit I., and Regev A. Nature biotechnology, 2011/05/01, Volume 29, Issue 5, p.436-42, (2011) Read More / View Supplemental Materials
Abstract
Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications.Yilmaz, P., Kottmann R., Field D., Knight R., Cole JR, Amaral-Zettler L., Gilbert JA, Karsch-Mizrachi I., Johnston A., Cochrane G., Vaughan R., Hunter C., Park J., Morrison N., Rocca-Serra P., Sterk P., Arumugam M., Bailey M., Baumgartner L., Birren BW, et al. Nature biotechnology, 2011/05/01, Volume 29, Issue 5, p.415-20, (2011) Read More / View Supplemental Materials
Abstract
Points of view: the overview figure.Wong, B. Nature methods, 2011/05/01, Volume 8, Issue 5, p.365, (2011) Read More / View Supplemental Materials
Targeting mutant fibroblast growth factor receptors in cancer.Greulich, H., and Pollock PM Trends in molecular medicine, 2011/05/01, Volume 17, Issue 5, p.283-92, (2011) Read More / View Supplemental Materials
Abstract
Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles.Comer, E., Liu H., Joliton A., Clabaut A., Johnson C., Akella LB, and Marcaurelle LA Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6751-6, (2011) Read More / View Supplemental Materials
Abstract
Organic synthesis toward small-molecule probes and drugs.Schreiber, SL Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6699-702, (2011) Read More / View Supplemental Materials
Abstract
Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.Clemons, PA, Wilson JA, Dančík V., Muller S., Carrinski HA, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6817-22, (2011) Read More / View Supplemental Materials
Abstract
Route to three-dimensional fragments using diversity-oriented synthesis.Hung, AW, Ramek A., Wang Y., Kaya T., Wilson JA, Clemons PA, and Young DW Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6799-804, (2011) Read More / View Supplemental Materials
Abstract
Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software.Kamentsky, L., Jones TR, Fraser A., Bray MA, Logan DJ, Madden KL, Ljosa V., Rueden C., Eliceiri KW, and Carpenter AE Bioinformatics (Oxford, England), 2011/04/15, Volume 27, Issue 8, p.1179-80, (2011) Read More / View Supplemental Materials
Abstract
Improving SNP discovery by base alignment quality.Li, H. Bioinformatics (Oxford, England), 2011/04/15, Volume 27, Issue 8, p.1157-8, (2011) Read More / View Supplemental Materials
Abstract
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.Cho, YJ, Tsherniak A., Tamayo P., Santagata S., Ligon A., Greulich H., Berhoukim R., Amani V., Goumnerova L., Eberhart CG, Lau CC, Olson JM, Gilbertson RJ, Gajjar A., Delattre O., Kool M., Ligon K., Meyerson M., Mesirov J. P., and Pomeroy SL Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/04/10, Volume 29, Issue 11, p.1424-30, (2011) Read More / View Supplemental Materials
Abstract
Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features.Tamayo, P., Cho YJ, Tsherniak A., Greulich H., Ambrogio L., Schouten-van Meeteren N., Zhou T., Buxton A., Kool M., Meyerson M., Pomeroy SL, and Mesirov J. P. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/04/10, Volume 29, Issue 11, p.1415-23, (2011) Read More / View Supplemental Materials
Abstract
Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.Heath, RJ, Leong JM, Visegrády B., Machesky LM, and Xavier RJ PLoS pathogens, 2011/04/01, Volume 7, Issue 4, p.e1001332, (2011) Read More / View Supplemental Materials
Abstract
Evaluation of large scale quantitative proteomic assay development using peptide affinity-based mass spectrometry.Whiteaker, JR, Zhao L., Abbatiello SE, Burgess M., Kuhn E., Lin C., Pope ME, Razavi M., Anderson NL, Pearson TW, Carr SA, and Paulovich AG Molecular & cellular proteomics : MCP, 2011/04/01, Volume 10, Issue 4, p.M110.005645, (2011) Read More / View Supplemental Materials
Abstract
Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.Van Tyne, D., Park DJ, Schaffner SF, Neafsey DE, Angelino E., Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA Jr, Johnson CA, Shlyakhter I., Grossman SR, Becker JS, Yamins D., Karlsson EK, Ndiaye D., Sarr O., Mboup S., et al. PLoS genetics, 2011/04/01, Volume 7, Issue 4, p.e1001383, (2011) Read More / View Supplemental Materials
Abstract
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.Rhee, EP, Cheng S., Larson MG, Walford GA, Lewis GD, McCabe E., Yang E., Farrell L., Fox CS, O'Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, and Gerszten RE The Journal of clinical investigation, 2011/04/01, Volume 121, Issue 4, p.1402-11, (2011) Read More / View Supplemental Materials
Abstract
Metabolite profiles and the risk of developing diabetes.Wang, TJ, Larson MG, Vasan RS, Cheng S., Rhee EP, McCabe E., Lewis GD, Fox CS, Jacques PF, Fernandez C., O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A., Melander O., Clish CB, and Gerszten RE Nature medicine, 2011/04/01, Volume 17, Issue 4, p.448-53, (2011) Read More / View Supplemental Materials
Abstract
Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling.Gu, H., Smith ZD, Bock C., Boyle P., Gnirke A., and Meissner A. Nature protocols, 2011/04/01, Volume 6, Issue 4, p.468-81, (2011) Read More / View Supplemental Materials
Abstract
Screening: Low-fat worms on drugs.Wagner, BK Nature chemical biology, 2011/04/01, Volume 7, Issue 4, p.194-5, (2011) Read More / View Supplemental Materials
Initial genome sequencing and analysis of multiple myeloma.Chapman, MA, Lawrence MS, Keats JJ, Cibulskis K., Sougnez C., Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M., Anderson KC, Ardlie KG, Auclair D., Baker A., Bergsagel PL, Bernstein BE, Drier Y., Fonseca R., Gabriel SB, Hofmeister CC, et al. Nature, 2011/03/24, Volume 471, Issue 7339, p.467-72, (2011) Read More / View Supplemental Materials
Abstract
Impulse control: temporal dynamics in gene transcription.Yosef, N., and Regev A. Cell, 2011/03/18, Volume 144, Issue 6, p.886-96, (2011) Read More / View Supplemental Materials
Abstract
Large-scale synthesis of all stereoisomers of a 2,3-unsaturated C-glycoside scaffold.Gerard, B., Marié JC, Pandya BA, Lee MD 4th, Liu H., and Marcaurelle LA The Journal of organic chemistry, 2011/03/18, Volume 76, Issue 6, p.1898-901, (2011) Read More / View Supplemental Materials
Abstract
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.Souza, A., Zhang J., and Clish CB Cancer cell, 2011/03/08, Volume 19, Issue 3, p.416-28, (2011) Read More / View Supplemental Materials
Abstract
Chemoproteomics quantifies complexity.Holson, EB, and Schreiber SL Nature biotechnology, 2011/03/01, Volume 29, Issue 3, p.235-6, (2011) Read More / View Supplemental Materials
Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons.Haas, BJ, Gevers D., Earl AM, Feldgarden M., Ward DV, Giannoukos G., Ciulla D., Tabbaa D., Highlander SK, Sodergren E., Methé B., DeSantis TZ, Human Microbiome Consortium, Petrosino JF, Knight R., and Birren BW Genome research, 2011/03/01, Volume 21, Issue 3, p.494-504, (2011) Read More / View Supplemental Materials
Abstract
Points of view: Points of review (part 2).Wong, B. Nature methods, 2011/03/01, Volume 8, Issue 3, p.189, (2011) Read More / View Supplemental Materials
Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance.Kang, MS, Lee EK, Soni V., Lewis TA, Koehler AN, Srinivasan V., and Kieff E. Journal of virology, 2011/03/01, Volume 85, Issue 6, p.2859-68, (2011) Read More / View Supplemental Materials
Abstract
Tabix: fast retrieval of sequence features from generic TAB-delimited files.Li, H. Bioinformatics (Oxford, England), 2011/03/01, Volume 27, Issue 5, p.718-9, (2011) Read More / View Supplemental Materials
Abstract
Genome-sequencing anniversary. The accelerator.Lander, E. S. Science (New York, N.Y.), 2011/02/25, Volume 331, Issue 6020, p.1024, (2011) Read More / View Supplemental Materials
Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.Green, MR, Monti S., Dalla-Favera R., Pasqualucci L., Walsh NC, Schmidt-Supprian M., Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K., Golub T. R., Alt F. W., Shipp M. A., and Manis J. P. Proceedings of the National Academy of Sciences of the United States of America, 2011/02/15, Volume 108, Issue 7, p.2873-8, (2011) Read More / View Supplemental Materials
Abstract
Visual representation of scientific information.Wong, B. Science signaling, 2011/02/15, Volume 4, Issue 160, p.pt1, (2011) Read More / View Supplemental Materials
Abstract