Scientific Publications

Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia.Petryshen, TL, Middleton FA, Tahl AR, Rockwell GN, Purcell S., Aldinger KA, Kirby A., Morley CP, McGann L., Gentile KL, Waggoner SG, Medeiros HM, Carvalho C., Macedo A., Albus M., Maier W., Trixler M., Eichhammer P., Schwab SG, Wildenauer DB, et al. Molecular psychiatry, 2005/12/01, Volume 10, Issue 12, p.1074-88, 1057, (2005) Read More / View Supplemental Materials

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Abstract

Genomics of the fungal kingdom: insights into eukaryotic biology.Galagan, JE, Henn MR, Ma LJ, Cuomo CA, and Birren B. Genome research, 2005/12/01, Volume 15, Issue 12, p.1620-31, (2005) Read More / View Supplemental Materials

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Abstract

Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.Plenge, RM, Padyukov L., Remmers EF, Purcell S., Lee AT, Karlson EW, Wolfe F., Kastner DL, Alfredsson L., Altshuler D., Gregersen PK, Klareskog L., and Rioux JD American journal of human genetics, 2005/12/01, Volume 77, Issue 6, p.1044-60, (2005) Read More / View Supplemental Materials

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• 4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.&body=http://www.broadinstitute.org/publications/view/3663" target="_blank">
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Abstract

Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains.Petryshen, TL, Kirby A., Hammer RP Jr, Purcell S., O'Leary SB, Singer JB, Hill AE, Nadeau JH, Daly M. J., and Sklar P. Genetics, 2005/12/01, Volume 171, Issue 4, p.1895-904, (2005) Read More / View Supplemental Materials

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Abstract

Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasisPegtel, Dirk M., Subramanian Aravind, Sheen Tzung-Shiahn, Tsai Ching-Hwa, Golub Todd R., and Thorley-Lawson David A. Journal of Virology, 2005/12//, Volume 79, Issue 24, p.15430 - 42, (2005) Read More / View Supplemental Materials

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Abstract

The impact of Life Science Identifier on informatics dataMartin, Sean, Hohman Moses M., and Liefeld Ted Drug Discovery Today, 2005/11/15/, Volume 10, Issue 22, p.1566 - 72, (2005) Read More / View Supplemental Materials

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Abstract

Calibrating a coalescent simulation of human genome sequence variation.Schaffner, SF, Foo C., Gabriel S., Reich D., Daly M. J., and Altshuler D. Genome research, 2005/11/01, Volume 15, Issue 11, p.1576-83, (2005) Read More / View Supplemental Materials

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Abstract

The case for selection at CCR5-Delta32.Sabeti, PC, Walsh E., Schaffner SF, Varilly P., Fry B., Hutcheson HB, Cullen M., Mikkelsen TS, Roy J., Patterson N., Cooper R., Reich D., Altshuler D., O'Brien S., and Lander E. S. PLoS biology, 2005/11/01, Volume 3, Issue 11, p.e378, (2005) Read More / View Supplemental Materials

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Abstract

Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.Greulich, H., Chen TH, Feng W., Jänne PA, Alvarez JV, Zappaterra M., Bulmer SE, Frank DA, Hahn WC, Sellers WR, and Meyerson M. PLoS medicine, 2005/11/01, Volume 2, Issue 11, p.e313, (2005) Read More / View Supplemental Materials

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Abstract

Allele-specific amplification in cancer revealed by SNP array analysisLaFramboise, Thomas, Weir Barbara A., Zhao Xiaojun, Beroukhim Rameen, Li Cheng, Harrington David, Sellers William R., and Meyerson Matthew PLoS Computational Biology, 2005/11//, Volume 1, Issue 6, p.e65 - e65, (2005) Read More / View Supplemental Materials

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Abstract

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesSubramanian, Aravind, Tamayo Pablo, Mootha Vamsi K., Mukherjee Sayan, Ebert Benjamin L., Gillette Michael A., Paulovich Amanda, Pomeroy Scott L., Golub Todd R., Lander Eric S., and Mesirov Jill P. Proceedings of the National Academy of Sciences of the United States of America, 2005/10/25/, Volume 102, Issue 43, p.15545 - 50, (2005) Read More / View Supplemental Materials

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Abstract

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.Subramanian, A., Tamayo P., Mootha VK, Mukherjee S., Ebert BL, Gillette MA, Paulovich A., Pomeroy SL, Golub T. R., Lander E. S., and Mesirov J. P. Proceedings of the National Academy of Sciences of the United States of America, 2005/10/25, Volume 102, Issue 43, p.15545-50, (2005) Read More / View Supplemental Materials

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Abstract

Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin.Raisner, RM, Hartley PD, Meneghini MD, Bao MZ, Liu CL, Schreiber SL, Rando OJ, and Madhani HD Cell, 2005/10/21, Volume 123, Issue 2, p.233-48, (2005) Read More / View Supplemental Materials

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Abstract

SpectralNET--an application for spectral graph analysis and visualization.Forman, JJ, Clemons PA, Schreiber SL, and Haggarty SJ BMC bioinformatics, 2005/10/19, Volume 6, p.260, (2005) Read More / View Supplemental Materials

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Abstract

Gefitinib induces myeloid differentiation of acute myeloid leukemiaStegmaier, Kimberly, Corsello Steven M., Ross Kenneth N., Wong Jenny S., Deangelo Daniel J., and Golub Todd R. Blood, 2005/10/15/, Volume 106, Issue 8, p.2841 - 8, (2005) Read More / View Supplemental Materials

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Abstract

Gefitinib induces myeloid differentiation of acute myeloid leukemia.Stegmaier, K., Corsello SM, Ross KN, Wong JS, DeAngelo DJ, and Golub T. R. Blood, 2005/10/15, Volume 106, Issue 8, p.2841-8, (2005) Read More / View Supplemental Materials

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Abstract

Mass spectrometry-based proteomics turns quantitative.Ong, SE, and Mann M. Nature chemical biology, 2005/10/01, Volume 1, Issue 5, p.252-62, (2005) Read More / View Supplemental Materials

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Abstract

Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia.Fan, JB, and Sklar P. Molecular psychiatry, 2005/10/01, Volume 10, Issue 10, p.928-38, 891, (2005) Read More / View Supplemental Materials

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Abstract

The promise and perils of interpreting genetic associations in Crohn's disease.Trinh, TT, and Rioux JD Gut, 2005/10/01, Volume 54, Issue 10, p.1354-7, (2005) Read More / View Supplemental Materials

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Single-nucleosome mapping of histone modifications in S. cerevisiae.Liu, CL, Kaplan T., Kim M., Buratowski S., Schreiber SL, Friedman N., and Rando OJ PLoS biology, 2005/10/01, Volume 3, Issue 10, p.e328, (2005) Read More / View Supplemental Materials

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Abstract

DNA sequence and analysis of human chromosome 18.Nusbaum, C., Zody MC, Borowsky ML, Kamal M., Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K., FitzGerald MG, Yang X., Abouelleil A., Allen NR, Anderson S., Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., et al. Nature, 2005/09/22, Volume 437, Issue 7058, p.551-5, (2005) Read More / View Supplemental Materials

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Abstract

GeneCruiser: a web service for the annotation of microarray dataLiefeld, Ted, Reich Michael, Gould Joshua, Zhang Peili, Tamayo Pablo, and Mesirov Jill P. Bioinformatics (Oxford, England), 2005/09/15/, Volume 21, Issue 18, p.3681 - 2, (2005) Read More / View Supplemental Materials

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Abstract

GeneCruiser: a web service for the annotation of microarray data.Liefeld, T., Reich M., Gould J., Zhang P., Tamayo P., and Mesirov J. P. Bioinformatics (Oxford, England), 2005/09/15, Volume 21, Issue 18, p.3681-2, (2005) Read More / View Supplemental Materials

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Abstract

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibilityShepard, Jennifer L., Amatruda James F., Stern Howard M., Subramanian Aravind, Finkelstein David, Ziai James, Finley Rose K., Pfaff Kathleen L., Hersey Candace, Zhou Yi, Barut Bruce, Freedman Matthew, Lee Charles, Spitsbergen Jan, Neuberg Donna, and Weber Gerhard Proceedings of the National Academy of Sciences of the United States of America, 2005/09/13/, Volume 102, Issue 37, p.13194 - 9, (2005) Read More / View Supplemental Materials

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Abstract

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.Shepard, JL, Amatruda JF, Stern HM, Subramanian A., Finkelstein D., Ziai J., Finley KR, Pfaff KL, Hersey C., Zhou Y., Barut B., Freedman M., Lee C., Spitsbergen J., Neuberg D., Weber G., Golub T. R., Glickman JN, Kutok JL, Aster J. C., et al. Proceedings of the National Academy of Sciences of the United States of America, 2005/09/13, Volume 102, Issue 37, p.13194-9, (2005) Read More / View Supplemental Materials

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Abstract

A high-density screen for linkage in multiple sclerosis.Sawcer, S., Ban M., Maranian M., Yeo TW, Compston A., Kirby A., Daly M. J., De Jager PL, Walsh E., Lander E. S., Rioux JD, Hafler DA, Ivinson A., Rimmler J., Gregory SG, Schmidt S., Pericak-Vance MA, Akesson E., Hillert J., Datta P., et al. American journal of human genetics, 2005/09/01, Volume 77, Issue 3, p.454-67, (2005) Read More / View Supplemental Materials

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Abstract

From solution-phase to solid-phase enyne metathesis: crossover in the relative performance of two commonly used ruthenium pre-catalysts.Brittain, DE, Gray BL, and Schreiber SL Chemistry (Weinheim an der Bergstrasse, Germany), 2005/08/19, Volume 11, Issue 17, p.5086-93, (2005) Read More / View Supplemental Materials

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Abstract

NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypesFeuerhake, Friedrich, Kutok Jeffery L., Monti Stefano, Chen Wen, LaCasce Ann S., Cattoretti Giorgio, Kurtin Paul, Pinkus Geraldine S., de Leval Laurence, Harris Nancy L., Savage Kerry J., Neuberg Donna, Habermann Thomas M., Dalla-Favera Riccardo, Golub Todd R., and A Blood, 2005/08/15/, Volume 106, Issue 4, p.1392 - 9, (2005) Read More / View Supplemental Materials

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Abstract

A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk.Freedman, ML, Penney KL, Stram DO, Riley S., McKean-Cowdin R., Le Marchand L., Altshuler D., and Haiman CA Cancer research, 2005/08/15, Volume 65, Issue 16, p.7516-22, (2005) Read More / View Supplemental Materials

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Abstract

NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes.Feuerhake, F., Kutok JL, Monti S., Chen W., LaCasce AS, Cattoretti G., Kurtin P., Pinkus GS, de Leval L., Harris NL, Savage KJ, Neuberg D., Habermann TM, Dalla-Favera R., Golub T. R., Aster J. C., and Shipp M. A. Blood, 2005/08/15, Volume 106, Issue 4, p.1392-9, (2005) Read More / View Supplemental Materials

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Abstract

Assembly of polymorphic genomes: algorithms and application to Ciona savignyi.Vinson, JP, Jaffe DB, O'Neill K., Karlsson EK, Stange-Thomann N., Anderson S., Mesirov J. P., Satoh N., Satou Y., Nusbaum C., Birren B., Galagan JE, and Lander E. S. Genome research, 2005/08/01, Volume 15, Issue 8, p.1127-35, (2005) Read More / View Supplemental Materials

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Abstract

Imaging biomarkers in drug development: an overview of opportunities and open issues.Chandra, S., Muir C., Silva M., and Carr S. Journal of proteome research, 2005/07/20, Volume 4, Issue 4, p.1134-7, (2005) Read More / View Supplemental Materials

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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanomaGarraway, Levi A., Widlund Hans R., Rubin Mark A., Getz Gad, Berger Aaron J., Ramaswamy Sridhar, Beroukhim Rameen, Milner Danny A., Granter Scott R., Du Jinyan, Lee Charles, Wagner Stephan N., Li Cheng, Golub Todd R., Rimm David L., Meyerson Matthew L., and Fisher David Nature, 2005/07/07/, Volume 436, Issue 7047, p.117 - 22, (2005) Read More / View Supplemental Materials

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Abstract

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.Garraway, LA, Widlund HR, Rubin MA, Getz G., Berger AJ, Ramaswamy S., Beroukhim R., Milner DA, Granter SR, Du J., Lee C., Wagner SN, Li C., Golub T. R., Rimm DL, Meyerson ML, Fisher DE, and Sellers WR Nature, 2005/07/07, Volume 436, Issue 7047, p.117-22, (2005) Read More / View Supplemental Materials

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Abstract

Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysisZhao, Xiaojun, Weir Barbara A., LaFramboise Thomas, Lin Ming, Beroukhim Rameen, Garraway Levi, Beheshti Javad, Lee Jeffrey C., Naoki Katsuhiko, Richards William G., Sugarbaker David, Chen Fei, Rubin Mark A., and J Cancer Research, 2005/07/01/, Volume 65, Issue 13, p.5561 - 70, (2005) Read More / View Supplemental Materials

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Abstract

Association of DLG5 R30Q variant with inflammatory bowel disease.Daly, M. J., Pearce AV, Farwell L., Fisher SA, Latiano A., Prescott NJ, Forbes A., Mansfield J., Sanderson J., Langelier D., Cohen A., Bitton A., Wild G., Lewis CM, Annese V., Mathew CG, and Rioux JD European journal of human genetics : EJHG, 2005/07/01, Volume 13, Issue 7, p.835-9, (2005) Read More / View Supplemental Materials

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Abstract

Small molecules: the missing link in the central dogma.Schreiber, SL Nature chemical biology, 2005/07/01, Volume 1, Issue 2, p.64-6, (2005) Read More / View Supplemental Materials

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Abstract

Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer.Saji, S., Kawakami M., Hayashi S., Yoshida N., Hirose M., Horiguchi S., Itoh A., Funata N., Schreiber SL, Yoshida M., and Toi M. Oncogene, 2005/06/30, Volume 24, Issue 28, p.4531-9, (2005) Read More / View Supplemental Materials

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Abstract

Small-molecule diversity using a skeletal transformation strategy.Kumar, N., Kiuchi M., Tallarico JA, and Schreiber SL Organic letters, 2005/06/23, Volume 7, Issue 13, p.2535-8, (2005) Read More / View Supplemental Materials

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Abstract

An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarrayEbert, Benjamin L., Lee Michele M., Pretz Jennifer L., Subramanian Aravind, Mak Raymond, Golub Todd R., and Sieff Colin A. Blood, 2005/06/15/, Volume 105, Issue 12, p.4620 - 6, (2005) Read More / View Supplemental Materials

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Abstract

An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray.Ebert, BL, Lee MM, Pretz JL, Subramanian A., Mak R., Golub T. R., and Sieff CA Blood, 2005/06/15, Volume 105, Issue 12, p.4620-6, (2005) Read More / View Supplemental Materials

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Abstract

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.Hideshima, T., Bradner JE, Wong J., Chauhan D., Richardson P., Schreiber SL, and Anderson KC Proceedings of the National Academy of Sciences of the United States of America, 2005/06/14, Volume 102, Issue 24, p.8567-72, (2005) Read More / View Supplemental Materials

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Abstract

MicroRNA expression profiles classify human cancersLu, Jun, Getz Gad, Miska Eric A., Alvarez-Saavedra Ezequiel, Lamb Justin, Peck David, Sweet-Cordero Alejandro, Ebert Benjamin L., Mak Raymond H., Ferrando Adolfo A., Downing James R., Jacks Tyler, Horvitz Robert H., and Golub Todd R. Nature, 2005/06/09/, Volume 435, Issue 7043, p.834 - 8, (2005) Read More / View Supplemental Materials

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Abstract

MicroRNA expression profiles classify human cancers.Lu, J., Getz G., Miska EA, Alvarez-Saavedra E., Lamb J., Peck D., Sweet-Cordero A., Ebert BL, Mak RH, Ferrando AA, Downing J. R., Jacks T., Horvitz HR, and Golub T. R. Nature, 2005/06/09, Volume 435, Issue 7043, p.834-8, (2005) Read More / View Supplemental Materials

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Abstract

Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis.Van Stry, M., Kazlauskas A., Schreiber SL, and Symes K. Proceedings of the National Academy of Sciences of the United States of America, 2005/06/07, Volume 102, Issue 23, p.8233-8, (2005) Read More / View Supplemental Materials

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Abstract

Synthesis and biological evaluation of novel fumagillin and ovalicin analogues.Mazitschek, R., Huwe A., and Giannis A. Organic & biomolecular chemistry, 2005/06/07, Volume 3, Issue 11, p.2150-4, (2005) Read More / View Supplemental Materials

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Abstract

Genetic association studies of complex traits: design and analysis issues.Newton-Cheh, C., and Hirschhorn JN Mutation research, 2005/06/03, Volume 573, Issue 1-2, p.54-69, (2005) Read More / View Supplemental Materials

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Abstract

Paths to understanding the genetic basis of autoimmune disease.Rioux, JD, and Abbas AK Nature, 2005/06/02, Volume 435, Issue 7042, p.584-9, (2005) Read More / View Supplemental Materials

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Abstract

The principle of complementarity: chemical versus biological space.Haggarty, SJ Current opinion in chemical biology, 2005/06/01, Volume 9, Issue 3, p.296-303, (2005) Read More / View Supplemental Materials

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Abstract

Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer.Febbo, PG, Lowenberg M., Thorner AR, Brown M., Loda M., and Golub T. R. The Journal of urology, 2005/05/01, Volume 173, Issue 5, p.1772-7, (2005) Read More / View Supplemental Materials

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Abstract

DNA polymorphism detector: an automated tool that searches for allelic matches in public databases for discrepancies found in clone or cDNA sequences.Chang, CY, and LaBaer J. Bioinformatics (Oxford, England), 2005/05/01, Volume 21, Issue 9, p.2133-5, (2005) Read More / View Supplemental Materials

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Abstract

Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements.Ramanathan, A., Wang C., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2005/04/26, Volume 102, Issue 17, p.5992-7, (2005) Read More / View Supplemental Materials

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Abstract

Convergent diversity-oriented synthesis of small-molecule hybrids.Chen, C., Li X., Neumann CS, Lo MM, and Schreiber SL Angewandte Chemie (International ed. in English), 2005/04/08, Volume 44, Issue 15, p.2249-52, (2005) Read More / View Supplemental Materials

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.Levine, RL, Wadleigh M., Cools J., Ebert BL, Wernig G., Huntly BJ, Boggon TJ, Wlodarska I., Clark JJ, Moore S., Adelsperger J., Koo S., Lee JC, Gabriel S., Mercher T., D'Andrea A., Fröhling S., Döhner K., Marynen P., Vandenberghe P., et al. Cancer cell, 2005/04/01, Volume 7, Issue 4, p.387-97, (2005) Read More / View Supplemental Materials

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Abstract

A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms.Miretti, MM, Walsh EC, Ke X., Delgado M., Griffiths M., Hunt S., Morrison J., Whittaker P., Lander E. S., Cardon LR, Bentley DR, Rioux JD, Beck S., and Deloukas P. American journal of human genetics, 2005/04/01, Volume 76, Issue 4, p.634-46, (2005) Read More / View Supplemental Materials

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Abstract

Support for involvement of neuregulin 1 in schizophrenia pathophysiology.Petryshen, TL, Middleton FA, Kirby A., Aldinger KA, Purcell S., Tahl AR, Morley CP, McGann L., Gentile KL, Rockwell GN, Medeiros HM, Carvalho C., Macedo A., Dourado A., Valente J., Ferreira CP, Patterson NJ, Azevedo MH, Daly M. J., Pato CN, et al. Molecular psychiatry, 2005/04/01, Volume 10, Issue 4, p.366-74, 328, (2005) Read More / View Supplemental Materials

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Abstract

An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing.Margulies, EH, Vinson JP, NISC Comparative Sequencing Program, Miller W., Jaffe DB, Lindblad-Toh K., Chang JL, Green ED, Lander E. S., Mullikin JC, and Clamp M. Proceedings of the National Academy of Sciences of the United States of America, 2005/03/29, Volume 102, Issue 13, p.4795-800, (2005) Read More / View Supplemental Materials

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Abstract

Interacting genetic loci cause airway hyperresponsiveness.Ackerman, KG, Huang H., Grasemann H., Puma C., Singer JB, Hill AE, Lander E., Nadeau JH, Churchill GA, Drazen JM, and Beier DR Physiological genomics, 2005/03/21, Volume 21, Issue 1, p.105-11, (2005) Read More / View Supplemental Materials

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Abstract

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammalsXie, Xiaohui, Lu Jun, Kulbokas E. J., Golub Todd R., Mootha Vamsi, Lindblad-Toh Kerstin, Lander Eric S., and Kellis Manolis Nature, 2005/03/17/, Volume 434, Issue 7031, p.338 - 45, (2005) Read More / View Supplemental Materials

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Abstract

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals.Xie, X., Lu J., Kulbokas E. J., Golub T. R., Mootha V., Lindblad-Toh K., Lander E. S., and Kellis M. Nature, 2005/03/17, Volume 434, Issue 7031, p.338-45, (2005) Read More / View Supplemental Materials

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Abstract

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory responseMonti, Stefano, Savage Kerry J., Kutok Jeffery L., Feuerhake Friedrich, Kurtin Paul, Mihm Martin, Wu Bingyan, Pasqualucci Laura, Neuberg Donna, Aguiar Ricardo C. T., Dal Cin Paola, Ladd Christine, Pinkus Geraldine S., Salles Gilles, Harris Nancy Lee, and Dalla-Fave Blood, 2005/03/01/, Volume 105, Issue 5, p.1851 - 61, (2005) Read More / View Supplemental Materials

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Abstract

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response.Monti, S., Savage KJ, Kutok JL, Feuerhake F., Kurtin P., Mihm M., Wu B., Pasqualucci L., Neuberg D., Aguiar RC, Dal Cin P., Ladd C., Pinkus GS, Salles G., Harris NL, Dalla-Favera R., Habermann TM, Aster J. C., Golub T. R., and Shipp M. A. Blood, 2005/03/01, Volume 105, Issue 5, p.1851-61, (2005) Read More / View Supplemental Materials

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Abstract

Genetics. Harvesting medical information from the human family tree.Altshuler, D., and Clark AG Science (New York, N.Y.), 2005/02/18, Volume 307, Issue 5712, p.1052-3, (2005) Read More / View Supplemental Materials

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Improving genome annotations using phylogenetic profile anomaly detection.Mikkelsen, TS, Galagan JE, and Mesirov J. P. Bioinformatics (Oxford, England), 2005/02/15, Volume 21, Issue 4, p.464-70, (2005) Read More / View Supplemental Materials

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Abstract

Genome-wide association studies for common diseases and complex traits.Hirschhorn, JN, and Daly M. J. Nature reviews. Genetics, 2005/02/01, Volume 6, Issue 2, p.95-108, (2005) Read More / View Supplemental Materials

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Abstract

How old is the most recent ancestor of two copies of an allele?Patterson, NJ Genetics, 2005/02/01, Volume 169, Issue 2, p.1093-104, (2005) Read More / View Supplemental Materials

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Abstract

Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice.Singer, JB, Hill AE, Nadeau JH, and Lander E. S. Genetics, 2005/02/01, Volume 169, Issue 2, p.855-62, (2005) Read More / View Supplemental Materials

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Abstract

Using genome-wide transcriptional profiling to elucidate small-molecule mechanism.Butcher, RA, and Schreiber SL Current opinion in chemical biology, 2005/02/01, Volume 9, Issue 1, p.25-30, (2005) Read More / View Supplemental Materials

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Abstract

Genomic maps and comparative analysis of histone modifications in human and mouse.Bernstein, BE, Kamal M., Lindblad-Toh K., Bekiranov S., Bailey DK, Huebert DJ, McMahon S., Karlsson EK, Kulbokas EJ 3rd, Gingeras TR, Schreiber SL, and Lander E. S. Cell, 2005/01/28, Volume 120, Issue 2, p.169-81, (2005) Read More / View Supplemental Materials

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Abstract

Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.Wang, J., Iwasaki H., Krivtsov A., Febbo PG, Thorner AR, Ernst P., Anastasiadou E., Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub T. R., Armstrong SA, Akashi K., and Korsmeyer SJ The EMBO journal, 2005/01/26, Volume 24, Issue 2, p.368-81, (2005) Read More / View Supplemental Materials

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Abstract

Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons.Oguri, H., and Schreiber SL Organic letters, 2005/01/06, Volume 7, Issue 1, p.47-50, (2005) Read More / View Supplemental Materials

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Mapping posttranslational modifications of proteins by MS-based selective detection: application to phosphoproteomics.Carr, SA, Annan RS, and Huddleston MJ Methods in enzymology, 2005/01/01, Volume 405, p.82-115, (2005) Read More / View Supplemental Materials

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Abstract

An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis.Sweet-Cordero, A., Mukherjee S., Subramanian A., You H., Roix JJ, Ladd-Acosta C., Mesirov J., Golub T. R., and Jacks T. Nature genetics, 2005/01/01, Volume 37, Issue 1, p.48-55, (2005) Read More / View Supplemental Materials

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Abstract

An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysisSweet-Cordero, Alejandro, Mukherjee Sayan, Subramanian Aravind, You Han, Roix Jeffrey J., Ladd-Acosta Christine, Mesirov Jill, Golub Todd R., and Jacks Tyler Nature Genetics, 2005/01//, Volume 37, Issue 1, p.48 - 55, (2005) Read More / View Supplemental Materials

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Abstract

Identifying biologically active compound classes using phenotypic screening data and sampling statistics.Klekota, J., Brauner E., and Schreiber SL Journal of chemical information and modeling, 1969/12/31, Volume 45, Issue 6, p.1824-36, (2005) Read More / View Supplemental Materials

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Abstract

Identification of AML1-ETO Modulators with Chemical GenomicsCorsello, Steven M., Roti Giovanni, Ross Kenneth N., Chow Kwan T., Golub Todd R., and Stegmaier Kimberly, unknown, (2004) Read More / View Supplemental Materials

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Abstract

Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.Berger, R., Febbo PG, Majumder PK, Zhao JJ, Mukherjee S., Signoretti S., Campbell KT, Sellers WR, Roberts TM, Loda M., Golub T. R., and Hahn WC Cancer research, 2004/12/15, Volume 64, Issue 24, p.8867-75, (2004) Read More / View Supplemental Materials

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Abstract

A library of spirooxindoles based on a stereoselective three-component coupling reaction.Lo, MM, Neumann CS, Nagayama S., Perlstein EO, and Schreiber SL Journal of the American Chemical Society, 2004/12/15, Volume 126, Issue 49, p.16077-86, (2004) Read More / View Supplemental Materials

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Abstract

Program to improve cognitive functioning in patients with schizophrenia: reflections.Scolnick, E. Schizophrenia research, 2004/12/15, Volume 72, Issue 1, p.75-7, (2004) Read More / View Supplemental Materials

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Abstract

Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF.Du, J., Widlund HR, Horstmann MA, Ramaswamy S., Ross K., Huber WE, Nishimura EK, Golub T. R., and Fisher DE Cancer cell, 2004/12/01, Volume 6, Issue 6, p.565-76, (2004) Read More / View Supplemental Materials

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Abstract

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips.Huang, J., Zhu H., Haggarty SJ, Spring DR, Hwang H., Jin F., Snyder M., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2004/11/23, Volume 101, Issue 47, p.16594-9, (2004) Read More / View Supplemental Materials

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Abstract

Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space.Kim, YK, Arai MA, Arai T., Lamenzo JO, Dean EF 3rd, Patterson N., Clemons PA, and Schreiber SL Journal of the American Chemical Society, 2004/11/17, Volume 126, Issue 45, p.14740-5, (2004) Read More / View Supplemental Materials

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Abstract

Stereochemical control of the Passerini reaction.Andreana, PR, Liu CC, and Schreiber SL Organic letters, 2004/11/11, Volume 6, Issue 23, p.4231-3, (2004) Read More / View Supplemental Materials

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Abstract

A synthesis strategy yielding skeletally diverse small molecules combinatorially.Burke, MD, Berger EM, and Schreiber SL Journal of the American Chemical Society, 2004/11/03, Volume 126, Issue 43, p.14095-104, (2004) Read More / View Supplemental Materials

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Abstract

A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice.Poirier, C., Qin Y., Adams CP, Anaya Y., Singer JB, Hill AE, Lander E. S., Nadeau JH, and Bishop CE Genetics, 2004/11/01, Volume 168, Issue 3, p.1557-62, (2004) Read More / View Supplemental Materials

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Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci.Rioux, JD, Karinen H., Kocher K., McMahon SG, Kärkkäinen P., Janatuinen E., Heikkinen M., Julkunen R., Pihlajamäki J., Naukkarinen A., Kosma VM, Daly M. J., Lander E. S., and Laakso M. American journal of medical genetics. Part A, 2004/11/01, Volume 130A, Issue 4, p.345-50, (2004) Read More / View Supplemental Materials

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Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors.Haggarty, SJ, Clemons PA, Wong JC, and Schreiber SL Combinatorial chemistry & high throughput screening, 2004/11/01, Volume 7, Issue 7, p.669-76, (2004) Read More / View Supplemental Materials

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Syntheses of stereochemically diverse nine-membered ring-containing biaryls.Krishnan, S., and Schreiber SL Organic letters, 2004/10/28, Volume 6, Issue 22, p.4021-4, (2004) Read More / View Supplemental Materials

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Abstract

Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype.Jaillon, O., Aury JM, Brunet F., Petit JL, Stange-Thomann N., Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C., Salanoubat M., Levy M., Boudet N., et al. Nature, 2004/10/21, Volume 431, Issue 7011, p.946-57, (2004) Read More / View Supplemental Materials

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Common variation in BRCA2 and breast cancer risk: a haplotype-based analysis in the Multiethnic Cohort.Freedman, ML, Penney KL, Stram DO, Le Marchand L., Hirschhorn JN, Kolonel LN, Altshuler D., Henderson BE, and Haiman CA Human molecular genetics, 2004/10/15, Volume 13, Issue 20, p.2431-41, (2004) Read More / View Supplemental Materials

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Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.Michalkiewicz, M., Michalkiewicz T., Ettinger RA, Rutledge EA, Fuller JM, Moralejo DH, Van Yserloo B., MacMurray AJ, Kwitek AE, Jacob HJ, Lander E. S., and Lernmark A. Physiological genomics, 2004/10/04, Volume 19, Issue 2, p.228-32, (2004) Read More / View Supplemental Materials

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Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains.Krewson, TD, Supelak PJ, Hill AE, Singer JB, Lander E. S., Nadeau JH, and Palmert MR Endocrinology, 2004/10/01, Volume 145, Issue 10, p.4447-51, (2004) Read More / View Supplemental Materials

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Abstract

Transcriptional regulatory code of a eukaryotic genome.Harbison, CT, Gordon DB, Lee TI, Rinaldi NJ, Macisaac KD, Danford TW, Hannett NM, Tagne JB, Reynolds DB, Yoo J., Jennings EG, Zeitlinger J., Pokholok DK, Kellis M., Rolfe PA, Takusagawa KT, Lander E. S., Gifford DK, Fraenkel E., and Young RA Nature, 2004/09/02, Volume 431, Issue 7004, p.99-104, (2004) Read More / View Supplemental Materials

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Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.Sawcer, SJ, Maranian M., Singlehurst S., Yeo T., Compston A., Daly M. J., De Jager PL, Gabriel S., Hafler DA, Ivinson AJ, Lander E. S., Rioux JD, Walsh E., Gregory SG, Schmidt S., Pericak-Vance MA, Barcellos L., Hauser SL, Oksenberg JR, Kenealy SJ, et al. Human molecular genetics, 2004/09/01, Volume 13, Issue 17, p.1943-9, (2004) Read More / View Supplemental Materials

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Abstract

Eric S. Lander.Lander, E. S. Nature reviews. Drug discovery, 2004/09/01, Volume 3, Issue 9, p.730, (2004) Read More / View Supplemental Materials

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Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes.Wong, JC, Sternson SM, Louca JB, Hong R., and Schreiber SL Chemistry & biology, 2004/09/01, Volume 11, Issue 9, p.1279-91, (2004) Read More / View Supplemental Materials

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RIP: the evolutionary cost of genome defense.Galagan, JE, and Selker EU Trends in genetics : TIG, 2004/09/01, Volume 20, Issue 9, p.417-23, (2004) Read More / View Supplemental Materials

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SNP genotyping using Sequenom MassARRAY 7K platform.Gabriel, S., and Ziaugra L. Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.], 2004/09/01, Volume Chapter 2, p.Unit 2.12, (2004) Read More / View Supplemental Materials

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Genomic approaches to hematologic malignanciesEbert, Benjamin L., and Golub Todd R. Blood, 2004/08/15/, Volume 104, Issue 4, p.923 - 32, (2004) Read More / View Supplemental Materials

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Abstract

Genomic approaches to hematologic malignancies.Ebert, BL, and Golub T. R. Blood, 2004/08/15, Volume 104, Issue 4, p.923-32, (2004) Read More / View Supplemental Materials

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