Scientific Publications

Search by Keyword(s)
Found 1608 results

Search Results

2010
Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.Ma, LJ, van der Does HC, Borkovich KA, Coleman JJ, Daboussi MJ, Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B., Houterman PM, Kang S., Shim WB, Woloshuk C., Xie X., Xu JR, Antoniw J., Baker SE, Bluhm BH, Breakspear A., et al. Nature, 2010/03/18, Volume 464, Issue 7287, p.367-73, (2010) Read More / View Supplemental Materials
Abstract
Molecular sampling of prostate cancer: a dilemma for predicting disease progression.Sboner, A., Demichelis F., Calza S., Pawitan Y., Setlur SR, Hoshida Y., Perner S., Adami HO, Fall K., Mucci LA, Kantoff PW, Stampfer M., Andersson SO, Varenhorst E., Johansson JE, Gerstein MB, Golub T. R., Rubin MA, and Andrén O. BMC medical genomics, 2010/03/16, Volume 3, p.8, (2010) Read More / View Supplemental Materials
Abstract
Blood pressure and human genetic variation in the general population.Arora, P., and Newton-Cheh C. Current opinion in cardiology, 2010/03/10, (2010) Read More / View Supplemental Materials
Abstract
Carbon metabolism-mediated myogenic differentiation.Bracha, AL, Ramanathan A., Huang S., Ingber DE, and Schreiber SL Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.202-204, (2010) Read More / View Supplemental Materials
Abstract
Chemical phylogenetics of histone deacetylases.Bradner, JE, West N., Grachan ML, Greenberg EF, Haggarty SJ, Warnow T., and Mazitschek R. Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.238-243, (2010) Read More / View Supplemental Materials
Abstract
Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke.Jimenez-Conde, J., Biffi A., Rahman R., Kanakis A., Butler C., Sonni S., Massasa E., Cloonan L., Gilson A., Capozzo K., Cortellini L., Ois A., Cuadrado-Godia E., Rodriguez-Campello A., Furie KL, Roquer J., Rosand J., and Rost NS Stroke; a journal of cerebral circulation, 2010/03/01, Volume 41, Issue 3, p.437-42, (2010) Read More / View Supplemental Materials
Abstract
Mining regulatory 5'UTRs from cDNA deep sequencing datasets.Livny, J., and Waldor MK Nucleic acids research, 2010/03/01, Volume 38, Issue 5, p.1504-14, (2010) Read More / View Supplemental Materials
Abstract
Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.Gohil, VM, Sheth SA, Nilsson R., Wojtovich AP, Lee JH, Perocchi F., Chen W., Clish CB, and Mootha VK Nature biotechnology, 2010/03/01, Volume 28, Issue 3, p.249-55, (2010) Read More / View Supplemental Materials
Abstract
Rapid behavior-based identification of neuroactive small molecules in the zebrafish.Kokel, D., Bryan J., Laggner C., White R., Cheung CY, Mateus R., Healey D., Kim S., Werdich AA, Haggarty SJ, Macrae CA, Shoichet B., and Peterson RT Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.231-237, (2010) Read More / View Supplemental Materials
Abstract
Synthetic chemistry: An upfront investment.Young, DW Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.174-175, (2010) Read More / View Supplemental Materials
Unbiased identification of protein-bait interactions using biochemical enrichment and quantitative proteomics.Ong, SE Cold Spring Harbor protocols, 2010/03/01, Volume 2010, Issue 3, p.pdb.prot5400, (2010) Read More / View Supplemental Materials
Abstract
The landscape of somatic copy-number alteration across human cancers.Beroukhim, R., Mermel CH, Porter D., Wei G., Raychaudhuri S., Donovan J., Barretina J., Boehm JS, Dobson J., Urashima M., Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L., Greulich H., Reich M., Winckler W., Lawrence MS, Weir BA, et al. Nature, 2010/02/18, Volume 463, Issue 7283, p.899-905, (2010) Read More / View Supplemental Materials
Abstract
A composite of multiple signals distinguishes causal variants in regions of positive selection.Grossman, SR, Shylakhter I., Karlsson EK, Byrne EH, Morales S., Frieden G., Hostetter E., Angelino E., Garber M., Zuk O., Lander E. S., Schaffner SF, and Sabeti PC Science (New York, N.Y.), 2010/02/12, Volume 327, Issue 5967, p.883-6, (2010) Read More / View Supplemental Materials
Abstract
The fast track to multidrug resistance.Kaufmann, BB, and Hung DT Molecular cell, 2010/02/12, Volume 37, Issue 3, p.297-8, (2010) Read More / View Supplemental Materials
Abstract
Analysis of high-throughput sequencing and annotation strategies for phage genomes.Henn, MR, Sullivan MB, Stange-Thomann N., Osburne MS, Berlin AM, Kelly L., Yandava C., Kodira C., Zeng Q., Weiand M., Sparrow T., Saif S., Giannoukos G., Young SK, Nusbaum C., Birren BW, and Chisholm SW PloS one, 2010/02/05, Volume 5, Issue 2, p.e9083, (2010) Read More / View Supplemental Materials
Abstract
Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry.Tabb, DL, Vega-Montoto L., Rudnick PA, Variyath AM, Ham AJ, Bunk DM, Kilpatrick LE, Billheimer DD, Blackman RK, Cardasis HL, Carr SA, Clauser KR, Jaffe JD, Kowalski KA, Neubert TA, Regnier FE, Schilling B., Tegeler TJ, Wang M., Wang P., et al. Journal of proteome research, 2010/02/05, Volume 9, Issue 2, p.761-76, (2010) Read More / View Supplemental Materials
Abstract
Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast.Radman-Livaja, M., Liu CL, Friedman N., Schreiber SL, and Rando OJ PLoS genetics, 2010/02/05, Volume 6, Issue 2, p.e1000837, (2010) Read More / View Supplemental Materials
Abstract
A scalable, fully automated process for construction of sequence-ready barcoded libraries for 454.Lennon, NJ, Lintner RE, Anderson S., Alvarez P., Barry A., Brockman W., Daza R., Erlich RL, Giannoukos G., Green L., Hollinger A., Hoover CA, Jaffe DB, Juhn F., McCarthy D., Perrin D., Ponchner K., Powers TL, Rizzolo K., Robbins D., et al. Genome biology, 2010/02/05, Volume 11, Issue 2, p.R15, (2010) Read More / View Supplemental Materials
Abstract
Analytical validation of protein-based multiplex assays: a workshop report by the NCI-FDA interagency oncology task force on molecular diagnostics.Rodriguez, H., Tezak Z., Mesri M., Carr SA, Liebler DC, Fisher SJ, Tempst P., Hiltke T., Kessler LG, Kinsinger CR, Philip R., Ransohoff DF, Skates SJ, Regnier FE, Anderson NL, Mansfield E., and Workshop Participants Clinical chemistry, 2010/02/01, Volume 56, Issue 2, p.237-43, (2010) Read More / View Supplemental Materials
Abstract
Automated detection of inaccurate and imprecise transitions in peptide quantification by multiple reaction monitoring mass spectrometry.Abbatiello, SE, Mani D. R., Keshishian H., and Carr SA Clinical chemistry, 2010/02/01, Volume 56, Issue 2, p.291-305, (2010) Read More / View Supplemental Materials
Abstract
CK1epsilon is required for breast cancers dependent on beta-catenin activity.Kim, SY, Dunn IF, Firestein R., Gupta P., Wardwell L., Repich K., Schinzel AC, Wittner B., Silver SJ, Root DE, Boehm JS, Ramaswamy S., Lander E. S., and Hahn WC PloS one, 2010/02/01, Volume 5, Issue 2, p.e8979, (2010) Read More / View Supplemental Materials
Abstract
Genetic structure of a unique admixed population: implications for medical research.Patterson, N., Petersen DC, van der Ross RE, Sudoyo H., Glashoff RH, Marzuki S., Reich D., and Hayes VM Human molecular genetics, 2010/02/01, Volume 19, Issue 3, p.411-9, (2010) Read More / View Supplemental Materials
Abstract
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.Saxena, R., Hivert MF, Langenberg C., Tanaka T., Pankow JS, Vollenweider P., Lyssenko V., Bouatia-Naji N., Dupuis J., Jackson AU, Kao WH, Li M., Glazer NL, Manning AK, Luan J., Stringham HM, Prokopenko I., Johnson T., Grarup N., Boesgaard TW, et al. Nature genetics, 2010/02/01, Volume 42, Issue 2, p.142-8, (2010) Read More / View Supplemental Materials
Abstract
Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution.Gu, H., Bock C., Mikkelsen TS, Jäger N., Smith ZD, Tomazou E., Gnirke A., Lander E. S., and Meissner A. Nature methods, 2010/02/01, Volume 7, Issue 2, p.133-6, (2010) Read More / View Supplemental Materials
Abstract
Integration of proteomic-based tools for improved biomarkers of myocardial injury.Gerszten, RE, Carr SA, and Sabatine M. Clinical chemistry, 2010/02/01, Volume 56, Issue 2, p.194-201, (2010) Read More / View Supplemental Materials
Abstract
Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance.Paulovich, AG, Billheimer D., Ham AJ, Vega-Montoto L., Rudnick PA, Tabb DL, Wang P., Blackman RK, Bunk DM, Cardasis HL, Clauser KR, Kinsinger CR, Schilling B., Tegeler TJ, Variyath AM, Wang M., Whiteaker JR, Zimmerman LJ, Fenyo D., Carr SA, et al. Molecular & cellular proteomics : MCP, 2010/02/01, Volume 9, Issue 2, p.242-54, (2010) Read More / View Supplemental Materials
Abstract
Introduction: Advances in protein analysis for the clinical laboratory.Hortin, GL, Carr SA, and Anderson NL Clinical chemistry, 2010/02/01, Volume 56, Issue 2, p.149-51, (2010) Read More / View Supplemental Materials
Molecular classification and novel targets in hepatocellular carcinoma: recent advancements.Hoshida, Y., Toffanin S., Lachenmayer A., Villanueva A., Minguez B., and Llovet JM Seminars in liver disease, 2010/02/01, Volume 30, Issue 1, p.35-51, (2010) Read More / View Supplemental Materials
Abstract
Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses.Rudnick, PA, Clauser KR, Kilpatrick LE, Tchekhovskoi DV, Neta P., Blonder N., Billheimer DD, Blackman RK, Bunk DM, Cardasis HL, Ham AJ, Jaffe JD, Kinsinger CR, Mesri M., Neubert TA, Schilling B., Tabb DL, Tegeler TJ, Vega-Montoto L., Variyath AM, et al. Molecular & cellular proteomics : MCP, 2010/02/01, Volume 9, Issue 2, p.225-41, (2010) Read More / View Supplemental Materials
Abstract
Protein-based multiplex assays: mock presubmissions to the US Food and Drug Administration.Regnier, FE, Skates SJ, Mesri M., Rodriguez H., Tezak Z., Kondratovich MV, Alterman MA, Levin JD, Roscoe D., Reilly E., Callaghan J., Kelm K., Brown D., Philip R., Carr SA, Liebler DC, Fisher SJ, Tempst P., Hiltke T., Kessler LG, et al. Clinical chemistry, 2010/02/01, Volume 56, Issue 2, p.165-71, (2010) Read More / View Supplemental Materials
Abstract
Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling.Kuai, L., Wang X., Madison JM, Schreiber SL, Scolnick EM, and Haggarty SJ ACS chemical neuroscience, 2010/01/28, Volume 1, Issue 4, p.325-342, (2010) Read More / View Supplemental Materials
Abstract
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.van Vugt, MA, Gardino AK, Linding R., Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H., Keezer SM, Li J., Pawson T., Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, and Yaffe MB PLoS biology, 2010/01/26, Volume 8, Issue 1, p.e1000287, (2010) Read More / View Supplemental Materials
Abstract
A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells.Shaham, O., Xu Q., Ramanathan A., Souza AL, Clish CB, and Mootha VK Proceedings of the National Academy of Sciences of the United States of America, 2010/01/26, Volume 107, Issue 4, p.1571-5, (2010) Read More / View Supplemental Materials
Abstract
Computer science. Accessible reproducible research.Mesirov, J. P. Science (New York, N.Y.), 2010/01/22, Volume 327, Issue 5964, p.415-6, (2010) Read More / View Supplemental Materials
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.Clish, CB, Iliopoulos O., and Weissleder R. Cell, 2010/01/22, Volume 140, Issue 2, p.280-93, (2010) Read More / View Supplemental Materials
Abstract
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.Verhaak, RG, Hoadley KA, Purdom E., Wang V., Qi Y., Wilkerson MD, Miller CR, Ding L., Golub T., Mesirov J. P., Alexe G., Lawrence M., O'Kelly M., Tamayo P., Weir BA, Gabriel S., Winckler W., Gupta S., Jakkula L., Feiler HS, et al. Cancer cell, 2010/01/19, Volume 17, Issue 1, p.98-110, (2010) Read More / View Supplemental Materials
Abstract
Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus.Fan, J., Ionita-Laza I., McQueen MB, Devlin B., Purcell S., Faraone SV, Allen MH, Bowden CL, Calabrese JR, Fossey MD, Friedman ES, Gyulai L., Hauser P., Ketter TB, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel JK, Sachs GS, Thase ME, et al. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010/01/05, Volume 153B, Issue 1, p.29-37, (2010) Read More / View Supplemental Materials
Abstract
Antiplasmodial activity of piperazine sulfonamides.Martyn, DC, Cortese JF, Tyndall E., Dick J., Mazitschek R., Munoz B., and Clardy J. Bioorganic & medicinal chemistry letters, 2010/01/01, Volume 20, Issue 1, p.218-21, (2010) Read More / View Supplemental Materials
Abstract
Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles.Tassa, C., Duffner JL, Lewis TA, Weissleder R., Schreiber SL, Koehler AN, and Shaw SY Bioconjugate chemistry, 2010/01/01, Volume 21, Issue 1, p.14-9, (2010) Read More / View Supplemental Materials
Abstract
Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA.Goren, A., Ozsolak F., Shoresh N., Ku M., Adli M., Hart C., Gymrek M., Zuk O., Regev A., Milos PM, and Bernstein BE Nature methods, 2010/01/01, Volume 7, Issue 1, p.47-9, (2010) Read More / View Supplemental Materials
Abstract
Detecting protein-small molecule interactions using fluorous small-molecule microarrays.Vegas, AJ, and Koehler AN Methods in molecular biology (Clifton, N.J.), 2010/01/01, Volume 669, p.43-55, (2010) Read More / View Supplemental Materials
Abstract
Discovery of Inhibitors of Anti-Apoptotic Protein A1Bittker, JA, Weiwer M., Wei G., Germain A., Brown E., Dandapani S., Munoz B., Palmer M., Golub T., and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2Hartland, CL, Youngsaye W., Morgan B., Ting A., Nag P., Buhrlage S., Johnston S., Bittker J., Vincent B., Whitesell L., Dandapani S., Macpherson L., Munoz B., Palmer M., Lindquist S., and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3Hartland, CL, Youngsaye W., Dockendorff C., Johnston S., Bittker J., Vincent B., Whitesell L., Dandapani S., Macpherson L., Munoz B., Palmer M., Lindquist S., and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
ML238: An Antimalarial Small Molecule of a Unique Structural ClassWeiwer, M., Mulrooney C., Massi D., Heidebrecht R., Wiegand R., Lukens AK, Dick J., Wirth D., Ekland E., Cheng CC, Zhao J., Yuan J., Su XZ, Johnson RL, Guha R., Dandapani S., Munoz B., Palmer M., Thomas C., Austin CP, et al., 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
Reconstructing gene histories in Ascomycota fungi.Wapinski, I., and Regev A. Methods in enzymology, 2010/01/01, Volume 470, p.447-85, (2010) Read More / View Supplemental Materials
Abstract
Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2Bittker, JA, Weiwer M., Lewis T., Shimada K., Yang WS, Macpherson L., Dandapani S., Munoz B., Palmer M., Stockwell BR, and Schreiber SL, 2010/01/01, (2010) Read More / View Supplemental Materials
Abstract
Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines.Martyn, DC, Nijjar A., Celatka CA, Mazitschek R., Cortese JF, Tyndall E., Liu H., Fitzgerald MM, O'Shea TJ, Danthi S., and Clardy J. Bioorganic & medicinal chemistry letters, 2010/01/01, Volume 20, Issue 1, p.228-31, (2010) Read More / View Supplemental Materials
Abstract
Understanding gene sequence variation in the context of transcription regulation in yeast.Gat-Viks, I., Meller R., Kupiec M., and Shamir R. PLoS genetics, 2010/01/01, Volume 6, Issue 1, p.e1000800, (2010) Read More / View Supplemental Materials
Abstract
2009
Direct control of mitochondrial function by mTOR.Ramanathan, A., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2009/12/29, Volume 106, Issue 52, p.22229-32, (2009) Read More / View Supplemental Materials
Abstract
A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection.Shapira, SD, Gat-Viks I., Shum BO, Dricot A., Degrace MM, Wu L., Gupta PB, Hao T., Silver SJ, Root DE, Hill DE, Regev A., and Hacohen N. Cell, 2009/12/24, Volume 139, Issue 7, p.1255-67, (2009) Read More / View Supplemental Materials
Abstract
Fungal regulatory evolution: cis and trans in the balance.Thompson, DA, and Regev A. FEBS letters, 2009/12/17, Volume 583, Issue 24, p.3959-65, (2009) Read More / View Supplemental Materials
Abstract
Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells.Stanley, SA, and Hung DT Science translational medicine, 2009/12/16, Volume 1, Issue 11, p.11ps13, (2009) Read More / View Supplemental Materials
Abstract
Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling.Wagner, BK, and Clemons PA Current opinion in chemical biology, 2009/12/01, Volume 13, Issue 5-6, p.539-48, (2009) Read More / View Supplemental Materials
Abstract
Dicer1 functions as a haploinsufficient tumor suppressor.Kumar, MS, Pester RE, Chen CY, Lane K., Chin C., Lu J., Kirsch DG, Golub T. R., and Jacks T. Genes & development, 2009/12/01, Volume 23, Issue 23, p.2700-4, (2009) Read More / View Supplemental Materials
Abstract
Introduction to the quantitative analysis of two-dimensional fluorescence microscopy images for cell-based screening.Ljosa, V., and Carpenter AE PLoS computational biology, 2009/12/01, Volume 5, Issue 12, p.e1000603, (2009) Read More / View Supplemental Materials
Retinal vasculopathy in a family with autosomal dominant dyskeratosis congenita.Johnson, CA, Hatfield M., and Pulido JS Ophthalmic genetics, 2009/12/01, Volume 30, Issue 4, p.181-4, (2009) Read More / View Supplemental Materials
Abstract
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.Markljung, E., Jiang L., Jaffe JD, Mikkelsen TS, Wallerman O., Larhammar M., Zhang X., Wang L., Saenz-Vash V., Gnirke A., Lindroth AM, Barrés R., Yan J., Strömberg S., De S., Pontén F., Lander E. S., Carr SA, Zierath JR, Kullander K., et al. PLoS biology, 2009/12/01, Volume 7, Issue 12, p.e1000256, (2009) Read More / View Supplemental Materials
Abstract
Copper-mediated amidation of heterocyclic and aromatic C-H bonds.Wang, Q., and Schreiber SL Organic letters, 2009/11/19, Volume 11, Issue 22, p.5178-80, (2009) Read More / View Supplemental Materials
Abstract
Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.Peng, LF, Stanton BZ, Maloof N., Wang X., and Schreiber SL Bioorganic & medicinal chemistry letters, 2009/11/15, Volume 19, Issue 22, p.6319-25, (2009) Read More / View Supplemental Materials
Abstract
Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells.Pizzirani, D., Roberti M., Grimaudo S., Di Cristina A., Pipitone RM, Tolomeo M., and Recanatini M. Journal of medicinal chemistry, 2009/11/12, Volume 52, Issue 21, p.6936-40, (2009) Read More / View Supplemental Materials
Abstract
Genome sequence, comparative analysis, and population genetics of the domestic horse.Wade, CM, Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear TL, Adelson DL, Bailey E., Bellone RR, Blöcker H., Distl O., Edgar RC, Garber M., Leeb T., Mauceli E., MacLeod JN, Penedo MC, Raison JM, Sharpe T., et al. Science (New York, N.Y.), 2009/11/06, Volume 326, Issue 5954, p.865-7, (2009) Read More / View Supplemental Materials
Abstract
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.Barbie, DA, Tamayo P., Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P., Meylan E., Scholl C., Fröhling S., Chan EM, Sos ML, Michel K., Mermel C., Silver SJ, Weir BA, Reiling JH, Sheng Q., Gupta PB, et al. Nature, 2009/11/05, Volume 462, Issue 7269, p.108-12, (2009) Read More / View Supplemental Materials
Abstract
Nodal morphogens.Schier, AF Cold Spring Harbor perspectives in biology, 2009/11/01, Volume 1, Issue 5, p.a003459, (2009) Read More / View Supplemental Materials
Abstract
Empirical Bayes analysis of quantitative proteomics experiments.Margolin, AA, Ong SE, Schenone M., Gould R., Schreiber SL, Carr SA, and Golub T. R. PloS one, 2009/10/14, Volume 4, Issue 10, p.e7454, (2009) Read More / View Supplemental Materials
Abstract
Comprehensive mapping of long-range interactions reveals folding principles of the human genome.Lieberman-Aiden, E., van Berkum NL, Williams L., Imakaev M., Ragoczy T., Telling A., Amit I., Lajoie BR, Sabo PJ, Dorschner MO, Sandstrom R., Bernstein B., Bender MA, Groudine M., Gnirke A., Stamatoyannopoulos J., Mirny LA, Lander E. S., and Dekker J. Science (New York, N.Y.), 2009/10/09, Volume 326, Issue 5950, p.289-93, (2009) Read More / View Supplemental Materials
Abstract
Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses.Amit, I., Garber M., Chevrier N., Leite AP, Donner Y., Eisenhaure T., Guttman M., Grenier JK, Li W., Zuk O., Schubert LA, Birditt B., Shay T., Goren A., Zhang X., Smith Z., Deering R., McDonald RC, Cabili M., Bernstein BE, et al. Science (New York, N.Y.), 2009/10/09, Volume 326, Issue 5950, p.257-63, (2009) Read More / View Supplemental Materials
Abstract
Proteomic and genetic approaches identify Syk as an AML target.Hahn, CK, Berchuck JE, Ross KN, Kakoza RM, Clauser K., Schinzel AC, Ross L., Galinsky I., Davis TN, Silver SJ, Root DE, Stone RM, DeAngelo DJ, Carroll M., Hahn WC, Carr SA, Golub T. R., Kung AL, and Stegmaier K. Cancer cell, 2009/10/06, Volume 16, Issue 4, p.281-94, (2009) Read More / View Supplemental Materials
Abstract
Alpha shapes applied to molecular shape characterization exhibit novel properties compared to established shape descriptors.Wilson, JA, Bender A., Kaya T., and Clemons PA Journal of chemical information and modeling, 2009/10/01, Volume 49, Issue 10, p.2231-41, (2009) Read More / View Supplemental Materials
Abstract
Identification and characterization of novel sirtuin inhibitor scaffolds.Sanders, BD, Jackson B., Brent M., Taylor AM, Dang W., Berger SL, Schreiber SL, Howitz K., and Marmorstein R. Bioorganic & medicinal chemistry, 2009/10/01, Volume 17, Issue 19, p.7031-41, (2009) Read More / View Supplemental Materials
Abstract
Quantification of cardiovascular biomarkers in patient plasma by targeted mass spectrometry and stable isotope dilution.Keshishian, H., Addona T., Burgess M., Mani D. R., Shi X., Kuhn E., Sabatine MS, Gerszten RE, and Carr SA Molecular & cellular proteomics : MCP, 2009/10/01, Volume 8, Issue 10, p.2339-49, (2009) Read More / View Supplemental Materials
Abstract
Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum.Martyn, DC, Beletsky G., Cortese JF, Tyndall E., Liu H., Fitzgerald MM, O'Shea TJ, Liang B., and Clardy J. Bioorganic & medicinal chemistry letters, 2009/10/01, Volume 19, Issue 19, p.5657-60, (2009) Read More / View Supplemental Materials
Abstract
Chemical tools for dissecting bacterial physiology and virulence.Stanley, SA, and Hung DT Biochemistry, 2009/09/22, Volume 48, Issue 37, p.8776-86, (2009) Read More / View Supplemental Materials
Abstract
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans.Haas, BJ, Kamoun S., Zody MC, Jiang RH, Handsaker RE, Cano LM, Grabherr M., Kodira CD, Raffaele S., Torto-Alalibo T., Bozkurt TO, Ah-Fong AM, Alvarado L., Anderson VL, Armstrong MR, Avrova A., Baxter L., Beynon J., Boevink PC, Bollmann SR, et al. Nature, 2009/09/17, Volume 461, Issue 7262, p.393-8, (2009) Read More / View Supplemental Materials
Abstract
Phase Coupled Meta-analysis: sensitive detection of oscillations in cell cycle gene expression, as applied to fission yeast.Pyne, S., Gutman R., Kim CS, and Futcher B. BMC genomics, 2009/09/17, Volume 10, p.440, (2009) Read More / View Supplemental Materials
Abstract
Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.Hoshida, Y., Nijman SM, Kobayashi M., Chan JA, Brunet JP, Chiang DY, Villanueva A., Newell P., Ikeda K., Hashimoto M., Watanabe G., Gabriel S., Friedman SL, Kumada H., Llovet JM, and Golub T. R. Cancer research, 2009/09/15, Volume 69, Issue 18, p.7385-92, (2009) Read More / View Supplemental Materials
Abstract
MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer.Olson, P., Lu J., Zhang H., Shai A., Chun MG, Wang Y., Libutti SK, Nakakura EK, Golub T. R., and Hanahan D. Genes & development, 2009/09/15, Volume 23, Issue 18, p.2152-65, (2009) Read More / View Supplemental Materials
Abstract
Using expression and genotype to predict drug response in yeast.Ruderfer, DM, Roberts DC, Schreiber SL, Perlstein EO, and Kruglyak L. PloS one, 2009/09/04, Volume 4, Issue 9, p.e6907, (2009) Read More / View Supplemental Materials
Abstract
Cancer stem cells: mirage or reality?Gupta, PB, Chaffer CL, and Weinberg R. A. Nature medicine, 2009/09/01, Volume 15, Issue 9, p.1010-2, (2009) Read More / View Supplemental Materials
Abstract
Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia.Huang, P., and Schier AF Development (Cambridge, England), 2009/09/01, Volume 136, Issue 18, p.3089-98, (2009) Read More / View Supplemental Materials
Abstract
Identification of selective inhibitors of cancer stem cells by high-throughput screening.Gupta, PB, Onder TT, Jiang G., Tao K., Kuperwasser C., Weinberg R. A., and Lander E. S. Cell, 2009/08/21, Volume 138, Issue 4, p.645-59, (2009) Read More / View Supplemental Materials
Abstract
Formation of the RFX gene regulatory complex induces folding of the interaction domain of RFXAP.Briggs, L., Laird K., Boss JM, and Garvie CW Proteins, 2009/08/15, Volume 76, Issue 3, p.655-64, (2009) Read More / View Supplemental Materials
Abstract
The Sequence Alignment/Map format and SAMtools.Li, H., Handsaker B., Wysoker A., Fennell T., Ruan J., Homer N., Marth G., Abecasis G., Durbin R., and 1000 Genome Project Data Processing Subgroup Bioinformatics (Oxford, England), 2009/08/15, Volume 25, Issue 16, p.2078-9, (2009) Read More / View Supplemental Materials
Abstract
Interpreting expression data with metabolic flux models: predicting Mycobacterium tuberculosis mycolic acid production.Colijn, C., Brandes A., Zucker J., Lun DS, Weiner B., Farhat MR, Cheng TY, Moody DB, Murray M., and Galagan JE PLoS computational biology, 2009/08/01, Volume 5, Issue 8, p.e1000489, (2009) Read More / View Supplemental Materials
Abstract
Taking aim at aggressive cancer cells.Lander, E., Jiang G., and Tao K. Cancer biology & therapy, 2009/08/01, Volume 8, Issue 16, p.ii, (2009) Read More / View Supplemental Materials
Transcriptional regulatory circuits: predicting numbers from alphabets.Kim, HD, Shay T., O'Shea EK, and Regev A. Science (New York, N.Y.), 2009/07/24, Volume 325, Issue 5939, p.429-32, (2009) Read More / View Supplemental Materials
Abstract
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression.Khalil, AM, Guttman M., Huarte M., Garber M., Raj A., Rivea Morales D., Thomas K., Presser A., Bernstein BE, van Oudenaarden A., Regev A., Lander E. S., and Rinn JL Proceedings of the National Academy of Sciences of the United States of America, 2009/07/14, Volume 106, Issue 28, p.11667-72, (2009) Read More / View Supplemental Materials
Abstract
SnapShot: Ca2+-calcineurin-NFAT signaling.Crabtree, GR, and Schreiber SL Cell, 2009/07/10, Volume 138, Issue 1, p.210, 210.e1, (2009) Read More / View Supplemental Materials
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.Vasudevan, KM, Barbie DA, Davies MA, Rabinovsky R., McNear CJ, Kim JJ, Hennessy BT, Tseng H., Pochanard P., Kim SY, Dunn IF, Schinzel AC, Sandy P., Hoersch S., Sheng Q., Gupta PB, Boehm JS, Reiling JH, Silver S., Lu Y., et al. Cancer cell, 2009/07/07, Volume 16, Issue 1, p.21-32, (2009) Read More / View Supplemental Materials
Abstract
microRNA expression during trophectoderm specification.Viswanathan, SR, Mermel CH, Lu J., Lu CW, Golub T. R., and Daley GQ PloS one, 2009/07/03, Volume 4, Issue 7, p.e6143, (2009) Read More / View Supplemental Materials
Abstract
Aziridines as intermediates in diversity-oriented syntheses of alkaloids.Taylor, AM, and Schreiber SL Tetrahedron letters, 2009/07/02, Volume 50, Issue 26, p.3230-3233, (2009) Read More / View Supplemental Materials
Abstract
Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication.Ma, LJ, Ibrahim AS, Skory C., Grabherr MG, Burger G., Butler M., Elias M., Idnurm A., Lang BF, Sone T., Abe A., Calvo SE, Corrochano LM, Engels R., Fu J., Hansberg W., Kim JM, Kodira CD, Koehrsen MJ, Liu B., et al. PLoS genetics, 2009/07/01, Volume 5, Issue 7, p.e1000549, (2009) Read More / View Supplemental Materials
Abstract
Lin28 promotes transformation and is associated with advanced human malignancies.Viswanathan, SR, Powers JT, Einhorn W., Hoshida Y., Ng TL, Toffanin S., O'Sullivan M., Lu J., Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R., Azam M., Teixeira J., Meyerson M., Hughes TP, Llovet JM, Radich J., et al. Nature genetics, 2009/07/01, Volume 41, Issue 7, p.843-8, (2009) Read More / View Supplemental Materials
Abstract
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma.Addona, TA, Abbatiello SE, Schilling B., Skates SJ, Mani D. R., Bunk DM, Spiegelman CH, Zimmerman LJ, Ham AJ, Keshishian H., Hall SC, Allen S., Blackman RK, Borchers CH, Buck C., Cardasis HL, Cusack MP, Dodder NG, Gibson BW, Held JM, et al. Nature biotechnology, 2009/07/01, Volume 27, Issue 7, p.633-41, (2009) Read More / View Supplemental Materials
Abstract
Identifying novel constrained elements by exploiting biased substitution patterns.Garber, M., Guttman M., Clamp M., Zody MC, Friedman N., and Xie X. Bioinformatics (Oxford, England), 2009/06/15, Volume 25, Issue 12, p.i54-62, (2009) Read More / View Supplemental Materials
Abstract
Identification of AML1-ETO modulators by chemical genomics.Corsello, SM, Roti G., Ross KN, Chow KT, Galinsky I., DeAngelo DJ, Stone RM, Kung AL, Golub T. R., and Stegmaier K. Blood, 2009/06/11, Volume 113, Issue 24, p.6193-205, (2009) Read More / View Supplemental Materials
Abstract
Accessing skeletal diversity using catalyst control: formation of n and n + 1 macrocyclic triazole rings.Kelly, AR, Wei J., Kesavan S., Marié JC, Windmon N., Young DW, and Marcaurelle LA Organic letters, 2009/06/04, Volume 11, Issue 11, p.2257-60, (2009) Read More / View Supplemental Materials
Abstract
Applications of genomics in melanoma oncogene discovery.Berger, MF, and Garraway LA Hematology/oncology clinics of North America, 2009/06/01, Volume 23, Issue 3, p.397-414, vii, (2009) Read More / View Supplemental Materials
Abstract
Developing multiplexed assays for troponin I and interleukin-33 in plasma by peptide immunoaffinity enrichment and targeted mass spectrometry.Kuhn, E., Addona T., Keshishian H., Burgess M., Mani D. R., Lee RT, Sabatine MS, Gerszten RE, and Carr SA Clinical chemistry, 2009/06/01, Volume 55, Issue 6, p.1108-17, (2009) Read More / View Supplemental Materials
Abstract
Directed sample interrogation utilizing an accurate mass exclusion-based data-dependent acquisition strategy (AMEx).Rudomin, EL, Carr SA, and Jaffe JD Journal of proteome research, 2009/06/01, Volume 8, Issue 6, p.3154-60, (2009) Read More / View Supplemental Materials
Abstract