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2006
Contributions of estrogen to ER-negative breast tumor growth.Gupta, PB, and Kuperwasser C. The Journal of steroid biochemistry and molecular biology, 2006/12/01, Volume 102, Issue 1-5, p.71-8, (2006) Read More / View Supplemental Materials
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Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.Lee, JC, Vivanco I., Beroukhim R., Huang JH, Feng WL, Debiasi RM, Yoshimoto K., King JC, Nghiemphu P., Yuza Y., Xu Q., Greulich H., Thomas RK, Paez JG, Peck TC, Linhart DJ, Glatt KA, Getz G., Onofrio R., Ziaugra L., et al. PLoS medicine, 2006/12/01, Volume 3, Issue 12, p.e485, (2006) Read More / View Supplemental Materials
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Identifying and quantifying sites of protein methylation by heavy methyl SILAC.Ong, SE, and Mann M. Current protocols in protein science / editorial board, John E. Coligan ... [et al.], 2006/12/01, Volume Chapter 14, p.Unit 14.9, (2006) Read More / View Supplemental Materials
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Population structure and eigenanalysis.Patterson, N., Price AL, and Reich D. PLoS genetics, 2006/12/01, Volume 2, Issue 12, p.e190, (2006) Read More / View Supplemental Materials
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A second fatty acid amide hydrolase with variable distribution among placental mammals.Wei, BQ, Mikkelsen TS, McKinney MK, Lander E. S., and Cravatt BF The Journal of biological chemistry, 2006/12/01, Volume 281, Issue 48, p.36569-78, (2006) Read More / View Supplemental Materials
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Variation in the human genome and the inherited basis of common disease.Gabriel, S. Seminars in oncology, 2006/12/01, Volume 33, Issue 6 Suppl 11, p.S46-9, (2006) Read More / View Supplemental Materials
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An oligomer-based approach to skeletal diversity in small-molecule synthesis.Spiegel, DA, Schroeder FC, Duvall JR, and Schreiber SL Journal of the American Chemical Society, 2006/11/22, Volume 128, Issue 46, p.14766-7, (2006) Read More / View Supplemental Materials
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SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.Duan, Z., Bradner JE, Greenberg E., LeVine R., Foster R., Mahoney J., and Seiden MV Clinical cancer research : an official journal of the American Association for Cancer Research, 2006/11/15, Volume 12, Issue 22, p.6844-52, (2006) Read More / View Supplemental Materials
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Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida.Bourlat, SJ, Juliusdottir T., Lowe CJ, Freeman R., Aronowicz J., Kirschner M., Lander E. S., Thorndyke M., Nakano H., Kohn AB, Heyland A., Moroz LL, Copley RR, and Telford MJ Nature, 2006/11/02, Volume 444, Issue 7115, p.85-8, (2006) Read More / View Supplemental Materials
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Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple independent patient cohortsHayes, Neil D., Monti Stefano, Parmigiani Giovanni, Gilks Blake C., Naoki Katsuhiko, Bhattacharjee Arindam, Socinski Mark A., Perou Charles, and Meyerson Matthew Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 2006/11/01/, Volume 24, Issue 31, p.5079 - 90, (2006) Read More / View Supplemental Materials
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Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.Mutsuddi, M., Morris DW, Waggoner SG, Daly M. J., Scolnick EM, and Sklar P. American journal of human genetics, 2006/11/01, Volume 79, Issue 5, p.903-9, (2006) Read More / View Supplemental Materials
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A functional candidate screen for coeliac disease genes.Curley, CR, Monsuur AJ, Wapenaar MC, Rioux JD, and Wijmenga C. European journal of human genetics : EJHG, 2006/11/01, Volume 14, Issue 11, p.1215-22, (2006) Read More / View Supplemental Materials
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Transferability of tag SNPs in genetic association studies in multiple populations.de Bakker, PI, Burtt NP, Graham RR, Guiducci C., Yelensky R., Drake JA, Bersaglieri T., Penney KL, Butler J., Young S., Onofrio RC, Lyon HN, Stram DO, Haiman CA, Freedman ML, Zhu X., Cooper R., Groop L., Kolonel LN, Henderson BE, et al. Nature genetics, 2006/11/01, Volume 38, Issue 11, p.1298-303, (2006) Read More / View Supplemental Materials
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Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.Saxena, R., Gianniny L., Burtt NP, Lyssenko V., Giuducci C., Sjögren M., Florez JC, Almgren P., Isomaa B., Orho-Melander M., Lindblad U., Daly M. J., Tuomi T., Hirschhorn JN, Ardlie KG, Groop LC, and Altshuler D. Diabetes, 2006/10/01, Volume 55, Issue 10, p.2890-5, (2006) Read More / View Supplemental Materials
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Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.Hieronymus, H., Lamb J., Ross KN, Peng XP, Clement C., Rodina A., Nieto M., Du J., Stegmaier K., Raj SM, Maloney KN, Clardy J., Hahn WC, Chiosis G., and Golub T. R. Cancer cell, 2006/10/01, Volume 10, Issue 4, p.321-30, (2006) Read More / View Supplemental Materials
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Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance.Wei, G., Twomey D., Lamb J., Schlis K., Agarwal J., Stam RW, Opferman JT, Sallan SE, den Boer ML, Pieters R., Golub T. R., and Armstrong SA Cancer cell, 2006/10/01, Volume 10, Issue 4, p.331-42, (2006) Read More / View Supplemental Materials
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A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.de Bakker, PI, McVean G., Sabeti PC, Miretti MM, Green T., Marchini J., Ke X., Monsuur AJ, Whittaker P., Delgado M., Morrison J., Richardson A., Walsh EC, Gao X., Galver L., Hart J., Hafler DA, Pericak-Vance M., Todd JA, Daly M. J., et al. Nature genetics, 2006/10/01, Volume 38, Issue 10, p.1166-72, (2006) Read More / View Supplemental Materials
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PEPPeR, a platform for experimental proteomic pattern recognition.Jaffe, JD, Mani D. R., Leptos KC, Church GM, Gillette MA, and Carr SA Molecular & cellular proteomics : MCP, 2006/10/01, Volume 5, Issue 10, p.1927-41, (2006) Read More / View Supplemental Materials
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Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulatorsHieronymus, Haley, Lamb Justin, Ross Kenneth N., Peng Xiao P., Clement Cristina, Rodina Anna, Nieto Maria, Du Jinyan, Stegmaier Kimberly, Raj Srilakshmi M., Maloney Katherine N., Clardy Jon, Hahn William C., Chiosis Gabriela, and Golub Todd R. Cancer Cell, 2006/10//, Volume 10, Issue 4, p.321 - 30, (2006) Read More / View Supplemental Materials
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Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistanceWei, Guo, Twomey David, Lamb Justin, Schlis Krysta, Agarwal Jyoti, Stam Ronald W., Opferman Joseph T., Sallan Stephen E., den Boer Monique L., Pieters Rob, Golub Todd R., and Armstrong Scott A. Cancer Cell, 2006/10//, Volume 10, Issue 4, p.331 - 42, (2006) Read More / View Supplemental Materials
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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and diseaseLamb, Justin, Crawford Emily D., Peck David, Modell Joshua W., Blat Irene C., Wrobel Matthew J., Lerner Jim, Brunet Jean-Philippe, Subramanian Aravind, Ross Kenneth N., Reich Michael, Hieronymus Haley, Wei Guo, Armstrong Scott A., Haggarty Stephen J., and Clemons Pau Science (New York, N.Y.), 2006/09/29/, Volume 313, Issue 5795, p.1929 - 35, (2006) Read More / View Supplemental Materials
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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.Lamb, J., Crawford ED, Peck D., Modell JW, Blat IC, Wrobel MJ, Lerner J., Brunet JP, Subramanian A., Ross KN, Reich M., Hieronymus H., Wei G., Armstrong SA, Haggarty SJ, Clemons PA, Wei R., Carr SA, Lander E. S., and Golub T. R. Science (New York, N.Y.), 2006/09/29, Volume 313, Issue 5795, p.1929-35, (2006) Read More / View Supplemental Materials
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Genomics. Genomics and the tree of life.Rokas, A. Science (New York, N.Y.), 2006/09/29, Volume 313, Issue 5795, p.1897-9, (2006) Read More / View Supplemental Materials
Brain evolution and uniqueness in the human genome.Amadio, JP, and Walsh CA Cell, 2006/09/22, Volume 126, Issue 6, p.1033-5, (2006) Read More / View Supplemental Materials
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Imaging of multiple mRNA targets using quantum dot based in situ hybridization and spectral deconvolution in clinical biopsies.Tholouli, E., Hoyland JA, Di Vizio D., O'connell F., Macdermott SA, Twomey D., Levenson R., Yin JA, Golub T. R., Loda M., and Byers R. Biochemical and biophysical research communications, 2006/09/22, Volume 348, Issue 2, p.628-36, (2006) Read More / View Supplemental Materials
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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.Frias, MA, Thoreen CC, Jaffe JD, Schroder W., Sculley T., Carr SA, and Sabatini DM Current biology : CB, 2006/09/19, Volume 16, Issue 18, p.1865-70, (2006) Read More / View Supplemental Materials
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Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics.Tolliday, N., Clemons PA, Ferraiolo P., Koehler AN, Lewis TA, Li X., Schreiber SL, Gerhard DS, and Eliasof S. Cancer research, 2006/09/15, Volume 66, Issue 18, p.8935-42, (2006) Read More / View Supplemental Materials
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Dorsoventral patterning in hemichordates: insights into early chordate evolution.Lowe, CJ, Terasaki M., Wu M., Freeman RM Jr, Runft L., Kwan K., Haigo S., Aronowicz J., Lander E., Gruber C., Smith M., Kirschner M., and Gerhart J. PLoS biology, 2006/09/01, Volume 4, Issue 9, p.e291, (2006) Read More / View Supplemental Materials
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Genome-scale loss-of-function screening with a lentiviral RNAi library.Root, DE, Hacohen N., Hahn WC, Lander E. S., and Sabatini DM Nature methods, 2006/09/01, Volume 3, Issue 9, p.715-9, (2006) Read More / View Supplemental Materials
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Cycloaddition reactions of imines with 3-thiosuccinic anhydrides: synthesis of the tricyclic core of martinellic acid.Ng, PY, Masse CE, and Shaw JT Organic letters, 2006/08/31, Volume 8, Issue 18, p.3999-4002, (2006) Read More / View Supplemental Materials
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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9Krivtsov, Andrei V., Twomey David, Feng Zhaohui, Stubbs Matthew C., Wang Yingzi, Faber Joerg, Levine Jason E., Wang Jing, Hahn William C., Gilliland Gary D., Golub Todd R., and Armstrong Scott A. Nature, 2006/08/17/, Volume 442, Issue 7104, p.818 - 22, (2006) Read More / View Supplemental Materials
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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.Krivtsov, AV, Twomey D., Feng Z., Stubbs MC, Wang Y., Faber J., Levine JE, Wang J., Hahn WC, Gilliland DG, Golub T. R., and Armstrong SA Nature, 2006/08/17, Volume 442, Issue 7104, p.818-22, (2006) Read More / View Supplemental Materials
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A transforming MET mutation discovered in non-small cell lung cancer using microarray-based resequencing.Tengs, T., Lee JC, Paez JG, Zhao X., LaFramboise T., Giannoukos G., and Thomas RK Cancer letters, 2006/08/08, Volume 239, Issue 2, p.227-33, (2006) Read More / View Supplemental Materials
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Comparative gene marker selection suiteGould, Joshua, Getz Gad, Monti Stefano, Reich Michael, and Mesirov Jill P. Bioinformatics (Oxford, England), 2006/08/01/, Volume 22, Issue 15, p.1924 - 5, (2006) Read More / View Supplemental Materials
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Comparative gene marker selection suite.Gould, J., Getz G., Monti S., Reich M., and Mesirov J. P. Bioinformatics (Oxford, England), 2006/08/01, Volume 22, Issue 15, p.1924-5, (2006) Read More / View Supplemental Materials
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A family of conserved noncoding elements derived from an ancient transposable element.Xie, X., Kamal M., and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2006/08/01, Volume 103, Issue 31, p.11659-64, (2006) Read More / View Supplemental Materials
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Protein biomarker discovery and validation: the long and uncertain path to clinical utility.Rifai, N., Gillette MA, and Carr SA Nature biotechnology, 2006/08/01, Volume 24, Issue 8, p.971-83, (2006) Read More / View Supplemental Materials
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Combo: a whole genome comparative browser.Engels, R., Yu T., Burge C., Mesirov J. P., DeCaprio D., and Galagan JE Bioinformatics (Oxford, England), 2006/07/15, Volume 22, Issue 14, p.1782-3, (2006) Read More / View Supplemental Materials
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Mouse models of lung cancer.Dutt, A., and Wong KK Clinical cancer research : an official journal of the American Association for Cancer Research, 2006/07/15, Volume 12, Issue 14 Pt 2, p.4396s-4402s, (2006) Read More / View Supplemental Materials
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MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.Pikman, Y., Lee BH, Mercher T., McDowell E., Ebert BL, Gozo M., Cuker A., Wernig G., Moore S., Galinsky I., DeAngelo DJ, Clark JJ, Lee SJ, Golub T. R., Wadleigh M., Gilliland DG, and Levine RL PLoS medicine, 2006/07/01, Volume 3, Issue 7, p.e270, (2006) Read More / View Supplemental Materials
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Query Chem: a Google-powered web search combining text and chemical structures.Klekota, J., Roth FP, and Schreiber SL Bioinformatics (Oxford, England), 2006/07/01, Volume 22, Issue 13, p.1670-3, (2006) Read More / View Supplemental Materials
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Genetic evidence for complex speciation of humans and chimpanzees.Patterson, N., Richter DJ, Gnerre S., Lander E. S., and Reich D. Nature, 2006/06/29, Volume 441, Issue 7097, p.1103-8, (2006) Read More / View Supplemental Materials
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Positive natural selection in the human lineage.Sabeti, PC, Schaffner SF, Fry B., Lohmueller J., Varilly P., Shamovsky O., Palma A., Mikkelsen TS, Altshuler D., and Lander E. S. Science (New York, N.Y.), 2006/06/16, Volume 312, Issue 5780, p.1614-20, (2006) Read More / View Supplemental Materials
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Haplotype-based association analysis of 56 functional candidate genes in the IBD6 locus on chromosome 19.Tello-Ruiz, MK, Curley C., DelMonte T., Giallourakis C., Kirby A., Miller K., Wild G., Cohen A., Langelier D., Latiano A., Wedemeyer N., Lander E., Schreiber S., Annese V., Daly M. J., and Rioux JD European journal of human genetics : EJHG, 2006/06/01, Volume 14, Issue 6, p.780-90, (2006) Read More / View Supplemental Materials
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Mechanisms of action of medicines for schizophrenia and bipolar illness: status and limitations.Scolnick, EM Biological psychiatry, 2006/06/01, Volume 59, Issue 11, p.1039-45, (2006) Read More / View Supplemental Materials
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Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions.Kumagai, N., Muncipinto G., and Schreiber SL Angewandte Chemie (International ed. in English), 2006/05/26, Volume 45, Issue 22, p.3635-8, (2006) Read More / View Supplemental Materials
Using high-throughput screening data to discriminate compounds with single-target effects from those with side effects.Klekota, J., Brauner E., Roth FP, and Schreiber SL Journal of chemical information and modeling, 2006/05/18, Volume 46, Issue 4, p.1549-62, (2006) Read More / View Supplemental Materials
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Macrocycloadditions leading to conformationally restricted small molecules.Looper, RE, Pizzirani D., and Schreiber SL Organic letters, 2006/05/11, Volume 8, Issue 10, p.2063-6, (2006) Read More / View Supplemental Materials
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A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.Graham, RR, Kozyrev SV, Baechler EC, Reddy MV, Plenge RM, Bauer JW, Ortmann WA, Koeuth T., González Escribano MF, Argentine and Spanish Collaborative Groups, Pons-Estel B., Petri M., Daly M., Gregersen PK, Martín J., Altshuler D., Behrens TW, and Alarcón-Riquelme ME Nature genetics, 2006/05/01, Volume 38, Issue 5, p.550-5, (2006) Read More / View Supplemental Materials
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Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma.Smith, R., Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub T. R., and Lessnick SL Cancer cell, 2006/05/01, Volume 9, Issue 5, p.405-16, (2006) Read More / View Supplemental Materials
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A robust small-molecule microarray platform for screening cell lysates.Bradner, JE, McPherson OM, Mazitschek R., Barnes-Seeman D., Shen JP, Dhaliwal J., Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P., Schreiber SL, and Koehler AN Chemistry & biology, 2006/05/01, Volume 13, Issue 5, p.493-504, (2006) Read More / View Supplemental Materials
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Systematic identification of human mitochondrial disease genes through integrative genomics.Calvo, S., Jain M., Xie X., Sheth SA, Chang B., Goldberger OA, Spinazzola A., Zeviani M., Carr SA, and Mootha VK Nature genetics, 2006/05/01, Volume 38, Issue 5, p.576-82, (2006) Read More / View Supplemental Materials
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Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcomaSmith, Richard, Owen Leah A., Trem Deborah J., Wong Jenny S., Whangbo Jennifer S., Golub Todd R., and Lessnick Stephen L. Cancer Cell, 2006/05//, Volume 9, Issue 5, p.405 - 16, (2006) Read More / View Supplemental Materials
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GenePattern 2.0Reich, Michael, Liefeld Ted, Gould Joshua, Lerner Jim, Tamayo Pablo, and Mesirov Jill P. Nature Genetics, 2006/05//, Volume 38, Issue 5, p.500 - 1, (2006) Read More / View Supplemental Materials
A bivalent chromatin structure marks key developmental genes in embryonic stem cells.Bernstein, BE, Mikkelsen TS, Xie X., Kamal M., Huebert DJ, Cuff J., Fry B., Meissner A., Wernig M., Plath K., Jaenisch R., Wagschal A., Feil R., Schreiber SL, and Lander E. S. Cell, 2006/04/21, Volume 125, Issue 2, p.315-26, (2006) Read More / View Supplemental Materials
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DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.Zody, MC, Garber M., Adams DJ, Sharpe T., Harrow J., Lupski JR, Nicholson C., Searle SM, Wilming L., Young SK, Abouelleil A., Allen NR, Bi W., Bloom T., Borowsky ML, Bugalter BE, Butler J., Chang JL, Chen CK, Cook A., et al. Nature, 2006/04/20, Volume 440, Issue 7087, p.1045-9, (2006) Read More / View Supplemental Materials
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Reactive oxygen species have a causal role in multiple forms of insulin resistance.Houstis, N., Rosen ED, and Lander E. S. Nature, 2006/04/13, Volume 440, Issue 7086, p.944-8, (2006) Read More / View Supplemental Materials
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Identification and classification of conserved RNA secondary structures in the human genome.Pedersen, JS, Bejerano G., Siepel A., Rosenbloom K., Lindblad-Toh K., Lander E. S., Kent J., Miller W., and Haussler D. PLoS computational biology, 2006/04/01, Volume 2, Issue 4, p.e33, (2006) Read More / View Supplemental Materials
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Analysis of the DNA sequence and duplication history of human chromosome 15.Zody, MC, Garber M., Sharpe T., Young SK, Rowen L., O'Neill K., Whittaker CA, Kamal M., Chang JL, Cuomo CA, Dewar K., FitzGerald MG, Kodira CD, Madan A., Qin S., Yang X., Abbasi N., Abouelleil A., Arachchi HM, Baradarani L., et al. Nature, 2006/03/30, Volume 440, Issue 7084, p.671-5, (2006) Read More / View Supplemental Materials
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A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.Moffat, J., Grueneberg DA, Yang X., Kim SY, Kloepfer AM, Hinkle G., Piqani B., Eisenhaure TM, Luo B., Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N., Hahn WC, Lander E. S., Sabatini DM, and Root DE Cell, 2006/03/24, Volume 124, Issue 6, p.1283-98, (2006) Read More / View Supplemental Materials
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Human chromosome 11 DNA sequence and analysis including novel gene identification.Taylor, TD, Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim DW, She X., Barlow KF, Bloom T., Bruford E., Chang JL, Cuomo CA, Eichler E., FitzGerald MG, Jaffe DB, LaButti K., et al. Nature, 2006/03/23, Volume 440, Issue 7083, p.497-500, (2006) Read More / View Supplemental Materials
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Divergent structural complexity from a linear reaction sequence: synthesis of fused and spirobicyclic gamma-lactams from common synthetic precursors.Masse, CE, Ng PY, Fukase Y., Sanchez-Roselló M., and Shaw JT Journal of combinatorial chemistry, 2006/03/18, Volume 8, Issue 3, p.293-6, (2006) Read More / View Supplemental Materials
A structurally diverse library of polycyclic lactams resulting from systematic placement of proximal functional groups.Mitchell, JM, and Shaw JT Angewandte Chemie (International ed. in English), 2006/03/03, Volume 45, Issue 11, p.1722-6, (2006) Read More / View Supplemental Materials
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer.Stanbrough, M., Bubley GJ, Ross K., Golub T. R., Rubin MA, Penning TM, Febbo PG, and Balk SP Cancer research, 2006/03/01, Volume 66, Issue 5, p.2815-25, (2006) Read More / View Supplemental Materials
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Revealing complex traits with small molecules and naturally recombinant yeast strains.Perlstein, EO, Ruderfer DM, Ramachandran G., Haggarty SJ, Kruglyak L., and Schreiber SL Chemistry & biology, 2006/03/01, Volume 13, Issue 3, p.319-27, (2006) Read More / View Supplemental Materials
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Searching for signals of evolutionary selection in 168 genes related to immune function.Walsh, EC, Sabeti P., Hutcheson HB, Fry B., Schaffner SF, de Bakker PI, Varilly P., Palma AA, Roy J., Cooper R., Winkler C., Zeng Y., de The G., Lander E. S., O'Brien S., and Altshuler D. Human genetics, 2006/03/01, Volume 119, Issue 1-2, p.92-102, (2006) Read More / View Supplemental Materials
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Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profilingBourquin, Jean-Pierre, Subramanian Aravind, Langebrake Claudia, Reinhardt Dirk, Bernard Olivier, Ballerini Paola, and Baruchel Andr Proceedings of the National Academy of Sciences of the United States of America, 2006/02/28/, Volume 103, Issue 9, p.3339 - 44, (2006) Read More / View Supplemental Materials
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Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.Bourquin, JP, Subramanian A., Langebrake C., Reinhardt D., Bernard O., Ballerini P., Baruchel A., Cavé H., Dastugue N., Hasle H., Kaspers GL, Lessard M., Michaux L., Vyas P., van Wering E., Zwaan CM, Golub T. R., and Orkin SH Proceedings of the National Academy of Sciences of the United States of America, 2006/02/28, Volume 103, Issue 9, p.3339-44, (2006) Read More / View Supplemental Materials
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A large family of ancient repeat elements in the human genome is under strong selection.Kamal, M., Xie X., and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2006/02/21, Volume 103, Issue 8, p.2740-5, (2006) Read More / View Supplemental Materials
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Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.Butcher, RA, Bhullar BS, Perlstein EO, Marsischky G., LaBaer J., and Schreiber SL Nature chemical biology, 2006/02/01, Volume 2, Issue 2, p.103-9, (2006) Read More / View Supplemental Materials
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BRAF mutation predicts sensitivity to MEK inhibition.Solit, DB, Garraway LA, Pratilas CA, Sawai A., Getz G., Basso A., Ye Q., Lobo JM, She Y., Osman I., Golub T. R., Sebolt-Leopold J., Sellers WR, and Rosen N. Nature, 2006/01/19, Volume 439, Issue 7074, p.358-62, (2006) Read More / View Supplemental Materials
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DNA sequence and analysis of human chromosome 8.Nusbaum, C., Mikkelsen TS, Zody MC, Asakawa S., Taudien S., Garber M., Kodira CD, Schueler MG, Shimizu A., Whittaker CA, Chang JL, Cuomo CA, Dewar K., FitzGerald MG, Yang X., Allen NR, Anderson S., Asakawa T., Blechschmidt K., Bloom T., et al. Nature, 2006/01/19, Volume 439, Issue 7074, p.331-5, (2006) Read More / View Supplemental Materials
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Enantioselective addition of terminal alkynes to isolated isoquinoline iminiums.Taylor, AM, and Schreiber SL Organic letters, 2006/01/05, Volume 8, Issue 1, p.143-6, (2006) Read More / View Supplemental Materials
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells.Bernstein BE, Mikkelsen TS, Xie Kamal Huebert DJ Cuff Fry Meissner X. M. J., M Wernig, K Plath, R Jaenisch, A Wagschal, R Feil, SL Schreiber, and ES Lander, Volume 125, Issue 2, p.233-6, (2006) Read More / View Supplemental Materials
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2005
Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.Galagan, JE, Calvo SE, Cuomo C., Ma LJ, Wortman JR, Batzoglou S., Lee SI, Baştürkmen M., Spevak CC, Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M., Butler J., Purcell S., Harris S., Braus GH, Draht O., Busch S., et al. Nature, 2005/12/22, Volume 438, Issue 7071, p.1105-15, (2005) Read More / View Supplemental Materials
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Big Pharma's Commedia.Steele, FR Cell, 2005/12/16, Volume 123, Issue 6, p.971-3, (2005) Read More / View Supplemental Materials
Genome sequence, comparative analysis and haplotype structure of the domestic dog.Lindblad-Toh, K., Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M., Clamp M., Chang JL, Kulbokas EJ 3rd, Zody MC, Mauceli E., Xie X., Breen M., Wayne RK, Ostrander EA, Ponting CP, Galibert F., Smith DR, de Jong PJ, Kirkness E., et al. Nature, 2005/12/08, Volume 438, Issue 7069, p.803-19, (2005) Read More / View Supplemental Materials
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Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.Urgaonkar, S., La Pierre HS, Meir I., Lund H., Raychaudhuri D., and Shaw JT Organic letters, 2005/12/08, Volume 7, Issue 25, p.5609-12, (2005) Read More / View Supplemental Materials
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Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformationIsakoff, Michael S., Sansam Courtney G., Tamayo Pablo, Subramanian Aravind, Evans Julia A., Fillmore Christine M., Wang Xi, Biegel Jaclyn A., Pomeroy Scott L., Mesirov Jill P., and Roberts Charles W. M. Proceedings of the National Academy of Sciences of the United States of America, 2005/12/06/, Volume 102, Issue 49, p.17745 - 50, (2005) Read More / View Supplemental Materials
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Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis.Pegtel, DM, Subramanian A., Sheen TS, Tsai CH, Golub T. R., and Thorley-Lawson DA Journal of virology, 2005/12/01, Volume 79, Issue 24, p.15430-42, (2005) Read More / View Supplemental Materials
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Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia.Petryshen, TL, Middleton FA, Tahl AR, Rockwell GN, Purcell S., Aldinger KA, Kirby A., Morley CP, McGann L., Gentile KL, Waggoner SG, Medeiros HM, Carvalho C., Macedo A., Albus M., Maier W., Trixler M., Eichhammer P., Schwab SG, Wildenauer DB, et al. Molecular psychiatry, 2005/12/01, Volume 10, Issue 12, p.1074-88, 1057, (2005) Read More / View Supplemental Materials
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Genomics of the fungal kingdom: insights into eukaryotic biology.Galagan, JE, Henn MR, Ma LJ, Cuomo CA, and Birren B. Genome research, 2005/12/01, Volume 15, Issue 12, p.1620-31, (2005) Read More / View Supplemental Materials
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Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.Plenge, RM, Padyukov L., Remmers EF, Purcell S., Lee AT, Karlson EW, Wolfe F., Kastner DL, Alfredsson L., Altshuler D., Gregersen PK, Klareskog L., and Rioux JD American journal of human genetics, 2005/12/01, Volume 77, Issue 6, p.1044-60, (2005) Read More / View Supplemental Materials
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Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains.Petryshen, TL, Kirby A., Hammer RP Jr, Purcell S., O'Leary SB, Singer JB, Hill AE, Nadeau JH, Daly M. J., and Sklar P. Genetics, 2005/12/01, Volume 171, Issue 4, p.1895-904, (2005) Read More / View Supplemental Materials
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Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasisPegtel, Dirk M., Subramanian Aravind, Sheen Tzung-Shiahn, Tsai Ching-Hwa, Golub Todd R., and Thorley-Lawson David A. Journal of Virology, 2005/12//, Volume 79, Issue 24, p.15430 - 42, (2005) Read More / View Supplemental Materials
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The impact of Life Science Identifier on informatics dataMartin, Sean, Hohman Moses M., and Liefeld Ted Drug Discovery Today, 2005/11/15/, Volume 10, Issue 22, p.1566 - 72, (2005) Read More / View Supplemental Materials
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Calibrating a coalescent simulation of human genome sequence variation.Schaffner, SF, Foo C., Gabriel S., Reich D., Daly M. J., and Altshuler D. Genome research, 2005/11/01, Volume 15, Issue 11, p.1576-83, (2005) Read More / View Supplemental Materials
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The case for selection at CCR5-Delta32.Sabeti, PC, Walsh E., Schaffner SF, Varilly P., Fry B., Hutcheson HB, Cullen M., Mikkelsen TS, Roy J., Patterson N., Cooper R., Reich D., Altshuler D., O'Brien S., and Lander E. S. PLoS biology, 2005/11/01, Volume 3, Issue 11, p.e378, (2005) Read More / View Supplemental Materials
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Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.Greulich, H., Chen TH, Feng W., Jänne PA, Alvarez JV, Zappaterra M., Bulmer SE, Frank DA, Hahn WC, Sellers WR, and Meyerson M. PLoS medicine, 2005/11/01, Volume 2, Issue 11, p.e313, (2005) Read More / View Supplemental Materials
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Allele-specific amplification in cancer revealed by SNP array analysisLaFramboise, Thomas, Weir Barbara A., Zhao Xiaojun, Beroukhim Rameen, Li Cheng, Harrington David, Sellers William R., and Meyerson Matthew PLoS Computational Biology, 2005/11//, Volume 1, Issue 6, p.e65 - e65, (2005) Read More / View Supplemental Materials
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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesSubramanian, Aravind, Tamayo Pablo, Mootha Vamsi K., Mukherjee Sayan, Ebert Benjamin L., Gillette Michael A., Paulovich Amanda, Pomeroy Scott L., Golub Todd R., Lander Eric S., and Mesirov Jill P. Proceedings of the National Academy of Sciences of the United States of America, 2005/10/25/, Volume 102, Issue 43, p.15545 - 50, (2005) Read More / View Supplemental Materials
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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.Subramanian, A., Tamayo P., Mootha VK, Mukherjee S., Ebert BL, Gillette MA, Paulovich A., Pomeroy SL, Golub T. R., Lander E. S., and Mesirov J. P. Proceedings of the National Academy of Sciences of the United States of America, 2005/10/25, Volume 102, Issue 43, p.15545-50, (2005) Read More / View Supplemental Materials
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Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin.Raisner, RM, Hartley PD, Meneghini MD, Bao MZ, Liu CL, Schreiber SL, Rando OJ, and Madhani HD Cell, 2005/10/21, Volume 123, Issue 2, p.233-48, (2005) Read More / View Supplemental Materials
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SpectralNET--an application for spectral graph analysis and visualization.Forman, JJ, Clemons PA, Schreiber SL, and Haggarty SJ BMC bioinformatics, 2005/10/19, Volume 6, p.260, (2005) Read More / View Supplemental Materials
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Gefitinib induces myeloid differentiation of acute myeloid leukemiaStegmaier, Kimberly, Corsello Steven M., Ross Kenneth N., Wong Jenny S., Deangelo Daniel J., and Golub Todd R. Blood, 2005/10/15/, Volume 106, Issue 8, p.2841 - 8, (2005) Read More / View Supplemental Materials
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Gefitinib induces myeloid differentiation of acute myeloid leukemia.Stegmaier, K., Corsello SM, Ross KN, Wong JS, DeAngelo DJ, and Golub T. R. Blood, 2005/10/15, Volume 106, Issue 8, p.2841-8, (2005) Read More / View Supplemental Materials
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Mass spectrometry-based proteomics turns quantitative.Ong, SE, and Mann M. Nature chemical biology, 2005/10/01, Volume 1, Issue 5, p.252-62, (2005) Read More / View Supplemental Materials
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Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia.Fan, JB, and Sklar P. Molecular psychiatry, 2005/10/01, Volume 10, Issue 10, p.928-38, 891, (2005) Read More / View Supplemental Materials
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The promise and perils of interpreting genetic associations in Crohn's disease.Trinh, TT, and Rioux JD Gut, 2005/10/01, Volume 54, Issue 10, p.1354-7, (2005) Read More / View Supplemental Materials
Single-nucleosome mapping of histone modifications in S. cerevisiae.Liu, CL, Kaplan T., Kim M., Buratowski S., Schreiber SL, Friedman N., and Rando OJ PLoS biology, 2005/10/01, Volume 3, Issue 10, p.e328, (2005) Read More / View Supplemental Materials
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