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2014
Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.Rajasagi, M., Shukla SA, Fritsch EF, Keskin DB, Deluca D., Carmona E., Zhang W., Sougnez C., Cibulskis K., Sidney J., Stevenson K., Ritz J., Neuberg D., Brusic V., Gabriel S., Lander E. S., Getz G., Hacohen N., and Wu CJ Blood, 2014/06/02, (2014) Read More / View Supplemental Materials
Abstract
Genome-scale neurogenetics: methodology and meaning.McCarroll, SA, Feng G., and Hyman SE Nature neuroscience, 2014/06/01, Volume 17, Issue 6, p.756-63, (2014) Read More / View Supplemental Materials
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Glycogen synthase kinase-3β inhibition ameliorates cardiac parasympathetic dysfunction in type 1 diabetic akita mice.Zhang, Y., Welzig CM, Picard KL, Du C., Wang B., Pan JQ, Kyriakis JM, Aronovitz MJ, Claycomb WC, Blanton RM, Park HJ, and Galper JB Diabetes, 2014/06/01, Volume 63, Issue 6, p.2097-113, (2014) Read More / View Supplemental Materials
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HLA-Binding Properties of Tumor Neoepitopes in Humans.Fritsch, EF, Rajasagi M., Ott PA, Brusic V., Hacohen N., and Wu CJ Cancer immunology research, 2014/06/01, Volume 2, Issue 6, p.522-9, (2014) Read More / View Supplemental Materials
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Integrated Pathway-Based Approach Identifies Association between Genomic Regions at CTCF and CACNB2 and Schizophrenia.Juraeva, D., Haenisch B., Zapatka M., Frank J., GROUP Investigators, group PSYCH-GEMS SCZ working, Witt SH, Mühleisen TW, Treutlein J., Strohmaier J., Meier S., Degenhardt F., Giegling I., Ripke S., Leber M., Lange C., Schulze TG, Mössner R., Nenadic I., Sauer H., et al. PLoS genetics, 2014/06/01, Volume 10, Issue 6, p.e1004345, (2014) Read More / View Supplemental Materials
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Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells.Hu, X., Im HK, Raj T., Brennan PJ, Trynka G., Teslovich N., Slowikowski K., Chen WM, Onengut S., Baecher-Allan C., De Jager PL, Rich SS, Stranger BE, Brenner MB, and Raychaudhuri S. PLoS genetics, 2014/06/01, Volume 10, Issue 6, p.e1004404, (2014) Read More / View Supplemental Materials
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Ubiquitin-Mediated Response to Microsporidia and Virus Infection in C. elegans.Bakowski, MA, Desjardins CA, Smelkinson MG, Dunbar TA, Lopez-Moyado IF, Rifkin SA, Cuomo CA, and Troemel ER PLoS pathogens, 2014/06/01, Volume 10, Issue 6, p.e1004200, (2014) Read More / View Supplemental Materials
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Vaccines and Melanoma.Ott, PA, Fritsch EF, Wu CJ, and Dranoff G. Hematology/oncology clinics of North America, 2014/06/01, Volume 28, Issue 3, p.559-569, (2014) Read More / View Supplemental Materials
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Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine.Van Allen, EM, Wagle N., Stojanov P., Perrin DL, Cibulskis K., Marlow S., Jane-Valbuena J., Friedrich DC, Kryukov G., Carter SL, McKenna A., Sivachenko A., Rosenberg M., Kiezun A., Voet D., Lawrence M., Lichtenstein LT, Gentry JG, Huang FW, Fostel J., et al. Nature medicine, 2014/06/01, Volume 20, Issue 6, p.682-8, (2014) Read More / View Supplemental Materials
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Whole-genome analyses of whole-brain data: working within an expanded search space.Medland, SE, Jahanshad N., Neale BM, and Thompson PM Nature neuroscience, 2014/06/01, Volume 17, Issue 6, p.791-800, (2014) Read More / View Supplemental Materials
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Protein-protein interactions and genetic diseases: The Interactome.Lage, K. Biochimica et biophysica acta, 2014/05/31, (2014) Read More / View Supplemental Materials
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The dog as a genetic model for immunoglobulin A (IgA) deficiency: Identification of several breeds with low serum IgA concentrations.Olsson, M., Frankowiack M., Tengvall K., Roosje P., Fall T., Ivansson E., Bergvall K., Hansson-Hamlin H., Sundberg K., Hedhammar A., Lindblad-Toh K., and Hammarström L. Veterinary immunology and immunopathology, 2014/05/27, (2014) Read More / View Supplemental Materials
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Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.Lee, Y., Dominy JE, Choi YJ, Jurczak M., Tolliday N., Camporez JP, Chim H., Lim JH, Ruan HB, Yang X., Vazquez F., Sicinski P., Shulman GI, and Puigserver P. Nature, 2014/05/25, (2014) Read More / View Supplemental Materials
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Genome Sequence of the Pathogenic Fungus Sporothrix schenckii (ATCC 58251).Cuomo, CA, Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A., Goldberg J., Young S., Zeng Q., and Birren BW Genome announcements, 2014/05/22, Volume 2, Issue 3, (2014) Read More / View Supplemental Materials
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FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder.Guancial, EA, Werner L., Bellmunt J., Bamias A., Choueiri TK, Ross R., Schutz FA, Park RS, O'Brien RJ, Hirsch MS, Barletta JA, Berman DM, Lis R., Loda M., Stack EC, Garraway LA, Riester M., Michor F., Kantoff PW, and Rosenberg JE Cancer medicine, 2014/05/21, (2014) Read More / View Supplemental Materials
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Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine.Wurst, JM, Drake EJ, Theriault JR, Jewett IT, VerPlank L., Perez JR, Dandapani S., Palmer M., Moskowitz SM, Schreiber SL, Munoz B., and Gulick AM ACS chemical biology, 2014/05/21, (2014) Read More / View Supplemental Materials
Abstract
PP2A-Mediated Regulation of Ras Signaling in G2 Is Essential for Stable Quiescence and Normal G1 Length.Naetar, N., Soundarapandian V., Litovchick L., Goguen KL, Sablina AA, Bowman-Colin C., Sicinski P., Hahn WC, DeCaprio JA, and Livingston DM Molecular cell, 2014/05/21, (2014) Read More / View Supplemental Materials
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Clawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (Centipedes).Undheim, EA, Jones A., Clauser KR, Holland JW, Pineda SS, King GF, and Fry BG Molecular biology and evolution, 2014/05/20, (2014) Read More / View Supplemental Materials
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Effect of Genetic Variants Associated With Plasma Homocysteine Levels on Stroke Risk.Cotlarciuc, I., Malik R., Holliday EG, Ahmadi KR, Paré G., Psaty BM, Fornage M., Hasan N., Rinne PE, Ikram MA, Markus HS, Rosand J., Mitchell BD, Kittner SJ, Meschia JF, van Meurs JB, Uitterlinden AG, Worrall BB, Dichgans M., Sharma P., et al. Stroke; a journal of cerebral circulation, 2014/05/20, (2014) Read More / View Supplemental Materials
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A genetic association study of D-dimer levels with 50K SNPs from a candidate gene chip in four ethnic groups.Weng, LC, Tang W., Rich SS, Smith NL, Redline S., O'Donnell CJ, Basu S., Reiner AP, Delaney JA, Tracy RP, Palmer CD, Young T., Yang Q., Folsom AR, and Cushman M. Thrombosis research, 2014/05/20, (2014) Read More / View Supplemental Materials
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Whole -exome sequencing identifies rare, functional CFH variants in families with macular degeneration.Yu, Y., Triebwasser MP, Wong EK, Schramm EC, Thomas B., Reynolds R., Mardis E., Atkinson JP, Daly M., Raychaudhuri S., Kavanagh D., and Seddon JM Human molecular genetics, 2014/05/20, (2014) Read More / View Supplemental Materials
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Dectin-1 dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.Tam, JM, Mansour MK, Khan NS, Seward M., Puranam S., Tanne A., Sokolovska A., Becker CE, Acharya M., Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A., Stuart LM, Xavier RJ, and Vyas JM The Journal of infectious diseases, 2014/05/19, (2014) Read More / View Supplemental Materials
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Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY.Brinsmade, SR, Alexander EL, Livny J., Stettner AI, Segrè D., Rhee KY, and Sonenshein AL Proceedings of the National Academy of Sciences of the United States of America, 2014/05/19, (2014) Read More / View Supplemental Materials
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Relating the metatranscriptome and metagenome of the human gut.Franzosa, EA, Morgan XC, Segata N., Waldron L., Reyes J., Earl AM, Giannoukos G., Boylan MR, Ciulla D., Gevers D., Izard J., Garrett WS, Chan AT, and Huttenhower C. Proceedings of the National Academy of Sciences of the United States of America, 2014/05/19, (2014) Read More / View Supplemental Materials
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Epigenomics of Alzheimer's disease.Bennett, DA, Yu L., Yang J., Srivastava GP, Aubin C., and De Jager PL Translational research : the journal of laboratory and clinical medicine, 2014/05/16, (2014) Read More / View Supplemental Materials
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Genome Sequence of Serratia plymuthica V4.Cleto, S., Van der Auwera G., Almeida C., Vieira MJ, Vlamakis H., and Kolter R. Genome announcements, 2014/05/15, Volume 2, Issue 3, (2014) Read More / View Supplemental Materials
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Global microRNA depletion suppresses tumor angiogenesis.Chen, S., Xue Y., Wu X., Le C., Bhutkar A., Bell EL, Zhang F., Langer R., and Sharp PA Genes & development, 2014/05/15, Volume 28, Issue 10, p.1054-67, (2014) Read More / View Supplemental Materials
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A Notch for noncoding RNA in melanoma.Garraway, LA The New England journal of medicine, 2014/05/15, Volume 370, Issue 20, p.1950-1, (2014) Read More / View Supplemental Materials
Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin.Durak, O., de Anda FC, Singh KK, Leussis MP, Petryshen TL, Sklar P., and Tsai LH Molecular psychiatry, 2014/05/13, (2014) Read More / View Supplemental Materials
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Interactions between chromosomal and nonchromosomal elements reveal missing heritability.Edwards, MD, Symbor-Nagrabska A., Dollard L., Gifford DK, and Fink GR Proceedings of the National Academy of Sciences of the United States of America, 2014/05/13, (2014) Read More / View Supplemental Materials
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Oribacterium parvum , sp. nov. and Oribacterium asaccharolyticum sp. nov. obligately anaerobic bacteria from the human oral cavity.Sizova, MV, Muller PA Jr, Stancyk DA, Panikov NS, Mandalakis M., Hazen A., Hohmann T., Doerfert SN, Fowle W., Earl AM, Nelson KE, and Epstein SS International journal of systematic and evolutionary microbiology, 2014/05/13, (2014) Read More / View Supplemental Materials
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Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing.Helman, E., Lawrence ML, Stewart C., Sougnez C., Getz G., and Meyerson M. Genome research, 2014/05/13, (2014) Read More / View Supplemental Materials
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Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.Lassen, KG, Kuballa P., Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L., Horn H., Mercer J., Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly M. J., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/05/12, (2014) Read More / View Supplemental Materials
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Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression.Xu, C., Fillmore CM, Koyama S., Wu H., Zhao Y., Chen Z., Herter-Sprie GS, Akbay EA, Tchaicha JH, Altabef A., Reibel JB, Walton Z., Ji H., Watanabe H., Jänne PA, Castrillon DH, Rustgi AK, Bass AJ, Freeman GJ, Padera RF, et al. Cancer cell, 2014/05/12, Volume 25, Issue 5, p.590-604, (2014) Read More / View Supplemental Materials
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A framework for installable external tools in Skyline.Broudy, D., Killeen T., Choi M., Shulman N., Mani D. R., Abbatiello SE, Mani D., Ahmad R., Sahu AK, Schilling B., Tamura K., Boss Y., Sharma V., Gibson BW, Carr SA, Vitek O., Maccoss MJ, and Maclean B. Bioinformatics (Oxford, England), 2014/05/09, (2014) Read More / View Supplemental Materials
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The uniporter: From newly identified parts to function.Kamer, KJ, Sancak Y., and Mootha VK Biochemical and biophysical research communications, 2014/05/09, (2014) Read More / View Supplemental Materials
Life Extension Factor Klotho Enhances Cognition.Dubal, DB, Yokoyama JS, Zhu L., Broestl L., Worden K., Wang D., Sturm VE, Kim D., Klein E., Yu GQ, Ho K., Eilertson KE, Yu L., Kuro-O M., De Jager PL, Coppola G., Small GW, Bennett DA, Kramer JH, Abraham CR, et al. Cell reports, 2014/05/07, (2014) Read More / View Supplemental Materials
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Mycobacterial esx-3 requires multiple components for iron acquisition.Siegrist, MS, Steigedal M., Ahmad R., Mehra A., Dragset MS, Schuster BM, Philips JA, Carr SA, and Rubin EJ mBio, 2014/05/06, Volume 5, Issue 3, (2014) Read More / View Supplemental Materials
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Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.Gong, Y., Zack TI, Morris LG, Lin K., Hukkelhoven E., Raheja R., Tan IL, Turcan S., Veeriah S., Meng S., Viale A., Schumacher SE, Palmedo P., Beroukhim R., and Chan TA Nature genetics, 2014/05/04, (2014) Read More / View Supplemental Materials
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Whole exome sequencing identifies three recessive FIG4 mutations in an apparently dominant pedigree with Charcot-Marie-Tooth disease.Menezes, MP, Waddell L., Lenk GM, Kaur S., Macarthur DG, Meisler MH, and Clarke NF Neuromuscular disorders : NMD, 2014/05/04, (2014) Read More / View Supplemental Materials
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A Genome-Wide Association Study Identifies Variants in Casein Kinase II (CSNK2A2) to be Associated with Leukocyte Telomere Length in a Punjabi Sikh Diabetic Cohort.Saxena, R., Bjonnes A., Prescott J., Dib P., Natt P., Lane J., Lerner M., Cooper JA, Ye Y., Li KW, Maubaret CG, Codd V., Brackett D., Mirabello L., Kraft P., Dinney CP, Stowell D., Peyton M., Ralhan S., Wander GS, et al. Circulation. Cardiovascular genetics, 2014/05/03, (2014) Read More / View Supplemental Materials
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Systems genetics: From GWAS to disease pathways.van der Sijde, MR, Ng A., and Fu J. Biochimica et biophysica acta, 2014/05/02, (2014) Read More / View Supplemental Materials
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Allelic Expression of Deleterious Protein-Coding Variants across Human Tissues.Kukurba, KR, Zhang R., Li X., Smith KS, Knowles DA, How Tan M., Piskol R., Lek M., Snyder M., Macarthur DG, Li JB, and Montgomery SB PLoS genetics, 2014/05/01, Volume 10, Issue 5, p.e1004304, (2014) Read More / View Supplemental Materials
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Biallelic Variants in TTLL5, Encoding a Tubulin Glutamylase, Cause Retinal Dystrophy.Sergouniotis, PI, Chakarova C., Murphy C., Becker M., Lenassi E., Arno G., Lek M., Macarthur DG, UCL-Exomes Consortium, Bhattacharya SS, Moore AT, Holder GE, Robson AG, Wolfrum U., Webster AR, and Plagnol V. American journal of human genetics, 2014/05/01, Volume 94, Issue 5, p.760-9, (2014) Read More / View Supplemental Materials
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Breaking Down RET Breakpoints in Lung Adenocarcinoma.Watanabe, H., Brooks AN, and Meyerson M. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014/05/01, Volume 9, Issue 5, p.590-2, (2014) Read More / View Supplemental Materials
Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal.Sun, D., Luo M., Jeong M., Rodriguez B., Xia Z., Hannah R., Wang H., Le T., Faull KF, Chen R., Gu H., Bock C., Meissner A., Göttgens B., Darlington GJ, Li W., and Goodell MA Cell stem cell, 2014/05/01, Volume 14, Issue 5, p.673-88, (2014) Read More / View Supplemental Materials
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Genomic insights into tuberculosis.Galagan, JE Nature reviews. Genetics, 2014/05/01, Volume 15, Issue 5, p.307-20, (2014) Read More / View Supplemental Materials
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Quality control and conduct of genome-wide association meta-analyses.Winkler, TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Mägi R., Ferreira T., Fall T., Graff M., Justice AE, Luan J., Gustafsson S., Randall JC, Vedantam S., Workalemahu T., Kilpeläinen TO, Scherag A., Esko T., Kutalik Z., Heid IM, et al. Nature protocols, 2014/05/01, Volume 9, Issue 5, p.1192-212, (2014) Read More / View Supplemental Materials
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Regulatory T cells in autoimmune neuroinflammation.Kleinewietfeld, M., and Hafler DA Immunological reviews, 2014/05/01, Volume 259, Issue 1, p.231-44, (2014) Read More / View Supplemental Materials
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Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway.Heijnen, HF, van Wijk R., Pereboom TC, Goos YJ, Seinen CW, van Oirschot BA, van Dooren R., Gastou M., Giles RH, van Solinge W., Kuijpers TW, Gazda HT, Bierings MB, Da Costa L., and Macinnes AW PLoS genetics, 2014/05/01, Volume 10, Issue 5, p.e1004371, (2014) Read More / View Supplemental Materials
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Selectivity in Genetic Association with Sub-classified Migraine in Women.Chasman, DI, Anttila V., Buring JE, Ridker PM, Schürks M., Kurth T., and International Headache Genetics Consortium PLoS genetics, 2014/05/01, Volume 10, Issue 5, p.e1004366, (2014) Read More / View Supplemental Materials
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Simulation of finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland.Wang, SR, Agarwala V., Flannick J., Chiang CW, Altshuler D., GoT2D Consortium, and Hirschhorn JN American journal of human genetics, 2014/05/01, Volume 94, Issue 5, p.710-20, (2014) Read More / View Supplemental Materials
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Towards Engineered Processes for Sequencing-Based Analysis of Single Circulating Tumor Cells.Adalsteinsson, VA, and Love JC Current opinion in chemical engineering, 2014/05/01, Volume 4, p.97-104, (2014) Read More / View Supplemental Materials
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Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer.Lohr, JG, Adalsteinsson VA, Cibulskis K., Choudhury AD, Rosenberg M., Cruz-Gordillo P., Francis JM, Zhang CZ, Shalek AK, Satija R., Trombetta JJ, Lu D., Tallapragada N., Tahirova N., Kim S., Blumenstiel B., Sougnez C., Lowe A., Wong B., Auclair D., et al. Nature biotechnology, 2014/05/01, Volume 32, Issue 5, p.479-84, (2014) Read More / View Supplemental Materials
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Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation.Avanesov, AS, Ma S., Pierce KA, Yim SH, Lee BC, Clish CB, and Gladyshev VN eLife, 2014/04/29, Volume 3, p.e02077, (2014) Read More / View Supplemental Materials
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'Lnc'-ing enhancers to MYC regulation.Younger, ST, and Rinn JL Cell research, 2014/04/29, (2014) Read More / View Supplemental Materials
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Natural selection and infectious disease in human populations.Karlsson, EK, Kwiatkowski DP, and Sabeti PC Nature reviews. Genetics, 2014/04/29, (2014) Read More / View Supplemental Materials
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High- and low-throughput scoring of fat mass and body fat distribution in C. elegans.Wählby, C., Lee Conery A., Bray MA, Kamentsky L., Larkins-Ford J., Sokolnicki KL, Veneskey M., Michaels K., Carpenter AE, and O'Rourke EJ Methods (San Diego, Calif.), 2014/04/28, (2014) Read More / View Supplemental Materials
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Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer.Forsberg, LA, Rasi C., Malmqvist N., Davies H., Pasupulati S., Pakalapati G., Sandgren J., de Ståhl TD, Zaghlool A., Giedraitis V., Lannfelt L., Score J., Cross NC, Absher D., Janson ET, Lindgren CM, Morris AP, Ingelsson E., Lind L., and Dumanski JP Nature genetics, 2014/04/28, (2014) Read More / View Supplemental Materials
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Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL.Wang, L., Shalek AK, Lawrence M., Ding R., Gaublomme JT, Pochet N., Stojanov P., Sougnez C., Shukla SA, Stevenson KE, Zhang W., Wong J., Sievers QL, Macdonald BT, Vartanov AR, Goldstein NR, Neuberg D., He X., Lander E., Hacohen N., et al. Blood, 2014/04/28, (2014) Read More / View Supplemental Materials
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A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors.Konieczkowski, DJ, Johannessen CM, Abudayyeh O., Kim JW, Cooper ZA, Piris A., Frederick DT, Barzily-Rokni M., Straussman R., Haq R., Fisher DE, Mesirov J. P., Hahn WC, Flaherty KT, Wargo JA, Tamayo P., and Garraway LA Cancer discovery, 2014/04/25, (2014) Read More / View Supplemental Materials
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PRADA: pipeline for RNA sequencing data analysis.Torres-García, W., Zheng S., Sivachenko A., Vegesna R., Wang Q., Yao R., Berger MF, Weinstein J. N., Getz G., and Verhaak RG Bioinformatics (Oxford, England), 2014/04/25, (2014) Read More / View Supplemental Materials
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CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration.Schaffer, AE, Eggens VR, Caglayan AO, Reuter MS, Scott E., Coufal NG, Silhavy JL, Xue Y., Kayserili H., Yasuno K., Rosti RO, Abdellateef M., Caglar C., Kasher PR, Cazemier JL, Weterman MA, Cantagrel V., Cai N., Zweier C., Altunoglu U., et al. Cell, 2014/04/24, Volume 157, Issue 3, p.651-63, (2014) Read More / View Supplemental Materials
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Guidelines for investigating causality of sequence variants in human disease.Macarthur, DG, Manolio TA, Dimmock DP, Rehm HL, Shendure J., Abecasis GR, Adams DR, Altman RB, Antonarakis SE, Ashley EA, Barrett JC, Biesecker LG, Conrad DF, Cooper GM, Cox NJ, Daly M. J., Gerstein MB, Goldstein DB, Hirschhorn JN, Leal SM, et al. Nature, 2014/04/24, Volume 508, Issue 7497, p.469-76, (2014) Read More / View Supplemental Materials
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Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.Placke, T., Faber K., Nonami A., Putwain SL, Salih HR, Heidel FH, Krämer A., Root DE, Barbie DA, Krivtsov AV, Armstrong SA, Hahn WC, Huntly BJ, Sykes SM, Milsom MD, Scholl C., and Fröhling S. Blood, 2014/04/24, (2014) Read More / View Supplemental Materials
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Targeted genomic rearrangements using CRISPR/Cas technology.Choi, PS, and Meyerson M. Nature communications, 2014/04/24, Volume 5, p.3728, (2014) Read More / View Supplemental Materials
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Using XHMM Software to Detect Copy Number Variation in Whole-Exome Sequencing Data.Fromer, M., and Purcell SM Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.], 2014/04/24, Volume 81, p.7.23.1-7.23.21, (2014) Read More / View Supplemental Materials
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Constant Growth Rate Can Be Supported by Decreasing Energy Flux and Increasing Aerobic Glycolysis.Slavov, N., Budnik BA, Schwab D., Airoldi EM, and van Oudenaarden A. Cell reports, 2014/04/23, (2014) Read More / View Supplemental Materials
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Contributions of the social environment to first-onset and recurrent mania.Gilman, SE, Ni MY, Dunn EC, Breslau J., McLaughlin KA, Smoller JW, and Perlis RH Molecular psychiatry, 2014/04/22, (2014) Read More / View Supplemental Materials
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RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice.Efeyan, A., Schweitzer LD, Bilate AM, Chang S., Kirak O., Lamming DW, and Sabatini DM Developmental cell, 2014/04/22, (2014) Read More / View Supplemental Materials
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Medicine's Uncomfortable Relationship With Math: Calculating Positive Predictive Value.Manrai, AK, Bhatia G., Strymish J., Kohane IS, and Jain SH JAMA internal medicine, 2014/04/21, (2014) Read More / View Supplemental Materials
Response to letter to the Editor.McLean, SA, Ulirsch JC, and Bortsov AV Pain, 2014/04/21, (2014) Read More / View Supplemental Materials
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells.Wu, X., Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S., Chen S., Jaenisch R., Zhang F., and Sharp PA Nature biotechnology, 2014/04/20, (2014) Read More / View Supplemental Materials
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Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.Lane, AA, Chapuy B., Lin CY, Tivey T., Li H., Townsend EC, van Bodegom D., Day TA, Wu SC, Liu H., Yoda A., Alexe G., Schinzel AC, Sullivan TJ, Malinge S., Taylor JE, Stegmaier K., Jaffe JD, Bustin M., Te Kronnie G., et al. Nature genetics, 2014/04/20, (2014) Read More / View Supplemental Materials
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Limit of metastability for liquid and vapor phases of water.Cho, WJ, Kim J., Lee J., Keyes T., Straub JE, and Kim KS Physical review letters, 2014/04/18, Volume 112, Issue 15, p.157802, (2014) Read More / View Supplemental Materials
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Methods for targeted mutagenesis in zebrafish using TALENs.Hwang, WY, Peterson RT, and Yeh JR Methods (San Diego, Calif.), 2014/04/18, (2014) Read More / View Supplemental Materials
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Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.Xiao, S., Yosef N., Yang J., Wang Y., Zhou L., Zhu C., Wu C., Baloglu E., Schmidt D., Ramesh R., Lobera M., Sundrud MS, Tsai PY, Xiang Z., Wang J., Xu Y., Lin X., Kretschmer K., Rahl PB, Young RA, et al. Immunity, 2014/04/17, Volume 40, Issue 4, p.477-89, (2014) Read More / View Supplemental Materials
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Describing Sequencing Results of Structural Chromosome Rearrangements with a Suggested Next-Generation Cytogenetic Nomenclature.Ordulu, Z., Wong KE, Currall BB, Ivanov AR, Pereira S., Althari S., Gusella JF, Talkowski ME, and Morton CC American journal of human genetics, 2014/04/16, (2014) Read More / View Supplemental Materials
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Functional Genomic Analysis of Human Mitochondrial RNA Processing.Wolf, AR, and Mootha VK Cell reports, 2014/04/16, (2014) Read More / View Supplemental Materials
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Heterogeneity in immune responses: from populations to single cells.Satija, R., and Shalek AK Trends in immunology, 2014/04/16, (2014) Read More / View Supplemental Materials
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Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis.Rampal, R., Al-Shahrour F., Abdel-Wahab O., Patel J., Brunel JP, Mermel CH, Bass AJ, Pretz J., Ahn J., Hricik T., Kilpivaara O., Wadleigh M., Busque L., Gilliland DG, Golub T. R., Ebert BL, and LeVine R. Blood, 2014/04/16, (2014) Read More / View Supplemental Materials
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Maximizing the Power of Principal Components Analysis of Correlated Phenotypes in Genome-wide Association Studies.Aschard, H., Vilhjálmsson BJ, Greliche N., Morange PE, Trégouët DA, and Kraft P. American journal of human genetics, 2014/04/15, (2014) Read More / View Supplemental Materials
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A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein.Pop, MS, Stransky N., Garvie CW, Theurillat JP, Lewis TA, Zhong C., Culyba EK, Lin F., Daniels DS, Pagliarini R., Ronco L., Koehler AN, and Garraway LA Molecular cancer therapeutics, 2014/04/15, (2014) Read More / View Supplemental Materials
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Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment.Seo, J., Giusti-Rodríguez P., Zhou Y., Rudenko A., Cho S., Ota KT, Park C., Patzke H., Madabhushi R., Pan L., Mungenast AE, Guan JS, Delalle I., and Tsai LH Cell, 2014/04/10, Volume 157, Issue 2, p.486-98, (2014) Read More / View Supplemental Materials
Abstract
Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells.Chen, WW, Birsoy K., Mihaylova MM, Snitkin H., Stasinski I., Yucel B., Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, and Sabatini DM Cell reports, 2014/04/10, Volume 7, Issue 1, p.27-34, (2014) Read More / View Supplemental Materials
Abstract
Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.Wainger, BJ, Kiskinis E., Mellin C., Wiskow O., Han SS, Sandoe J., Perez NP, Williams LA, Lee S., Boulting G., Berry JD, Brown RH Jr, Cudkowicz ME, Bean BP, Eggan K., and Woolf CJ Cell reports, 2014/04/10, Volume 7, Issue 1, p.1-11, (2014) Read More / View Supplemental Materials
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Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells.Suvà, ML, Rheinbay E., Gillespie SM, Patel AP, Wakimoto H., Rabkin SD, Riggi N., Chi AS, Cahill DP, Nahed BV, Curry WT, Martuza RL, Rivera MN, Rossetti N., Kasif S., Beik S., Kadri S., Tirosh I., Wortman I., Shalek AK, et al. Cell, 2014/04/09, (2014) Read More / View Supplemental Materials
Abstract
Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles.Wawer, MJ, Jaramillo DE, Dančik V., Fass DM, Haggarty SJ, Shamji AF, Wagner BK, Schreiber SL, and Clemons PA Journal of biomolecular screening, 2014/04/07, (2014) Read More / View Supplemental Materials
Abstract
Increasing the Content of High-Content Screening: An Overview.Singh, S., Carpenter AE, and Genovesio A. Journal of biomolecular screening, 2014/04/07, (2014) Read More / View Supplemental Materials
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Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity.Han, B., Diogo D., Eyre S., Kallberg H., Zhernakova A., Bowes J., Padyukov L., Okada Y., González-Gay MA, Rantapää-Dahlqvist S., Martin J., Huizinga TW, Plenge RM, Worthington J., Gregersen PK, Klareskog L., de Bakker PI, and Raychaudhuri S. American journal of human genetics, 2014/04/03, Volume 94, Issue 4, p.522-32, (2014) Read More / View Supplemental Materials
Abstract
Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage.Woo, D., Falcone GJ, Devan WJ, Brown WM, Biffi A., Howard TD, Anderson CD, Brouwers HB, Valant V., Battey TW, Radmanesh F., Raffeld MR, Baedorf-Kassis S., Deka R., Woo JG, Martin LJ, Haverbusch M., Moomaw CJ, Sun G., Broderick JP, et al. American journal of human genetics, 2014/04/03, Volume 94, Issue 4, p.511-21, (2014) Read More / View Supplemental Materials
Abstract
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.Birsoy, K., Possemato R., Lorbeer FK, Bayraktar EC, Thiru P., Yucel B., Wang T., Chen WW, Clish CB, and Sabatini DM Nature, 2014/04/03, Volume 508, Issue 7494, p.108-12, (2014) Read More / View Supplemental Materials
Abstract
Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-Cerebellar Atrophy, and Intractable Seizures.Zhang, X., Ling J., Barcia G., Jing L., Wu J., Barry BJ, Mochida GH, Hill RS, Weimer JM, Stein Q., Poduri A., Partlow JN, Ville D., Dulac O., Yu TW, Lam AT, Servattalab S., Rodriguez J., Boddaert N., Munnich A., et al. American journal of human genetics, 2014/04/03, Volume 94, Issue 4, p.547-58, (2014) Read More / View Supplemental Materials
Abstract
Perspective: Revealing molecular secrets.Hyman, SE Nature, 2014/04/03, Volume 508, Issue 7494, p.S20, (2014) Read More / View Supplemental Materials
Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation.Janbon, G., Ormerod KL, Paulet D., Byrnes EJ 3rd, Yadav V., Chatterjee G., Mullapudi N., Hon CC, Billmyre RB, Brunel F., Bahn YS, Chen W., Chen Y., Chow EW, Coppée JY, Floyd-Averette A., Gaillardin C., Gerik KJ, Goldberg J., Gonzalez-Hilarion S., et al. PLoS genetics, 2014/04/01, Volume 10, Issue 4, p.e1004261, (2014) Read More / View Supplemental Materials
Abstract
A Central Role for GRB10 in Regulation of Islet Function in Man.Prokopenko, I., Poon W., Mägi R., Prasad B R., Salehi SA, Almgren P., Osmark P., Bouatia-Naji N., Wierup N., Fall T., Stančáková A., Barker A., Lagou V., Osmond C., Xie W., Lahti J., Jackson AU, Cheng YC, Liu J., O'Connell JR, et al. PLoS genetics, 2014/04/01, Volume 10, Issue 4, p.e1004235, (2014) Read More / View Supplemental Materials
Abstract
Current concepts and clinical applications of stroke genetics.Falcone, GJ, Malik R., Dichgans M., and Rosand J. Lancet neurology, 2014/04/01, Volume 13, Issue 4, p.405-418, (2014) Read More / View Supplemental Materials
Abstract
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells.Trapnell, C., Cacchiarelli D., Grimsby J., Pokharel P., Li S., Morse M., Lennon NJ, Livak KJ, Mikkelsen TS, and Rinn JL Nature biotechnology, 2014/04/01, Volume 32, Issue 4, p.381-6, (2014) Read More / View Supplemental Materials
Abstract
Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history.Bergen, SE, O'Dushlaine CT, Lee PH, Fanous AH, Ruderfer DM, Ripke S., International Schizophrenia Consortium, Swedish Schizophrenia Consortium, Sullivan PF, Smoller JW, Purcell SM, and Corvin A. Schizophrenia research, 2014/04/01, Volume 154, Issue 1-3, p.48-53, (2014) Read More / View Supplemental Materials
Abstract
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.Flannick, J., Thorleifsson G., Beer NL, Jacobs SB, Grarup N., Burtt NP, Mahajan A., Fuchsberger C., Atzmon G., Benediktsson R., Blangero J., Bowden DW, Brandslund I., Brosnan J., Burslem F., Chambers J., Cho YS, Christensen C., Douglas DA, Duggirala R., et al. Nature genetics, 2014/04/01, Volume 46, Issue 4, p.357-63, (2014) Read More / View Supplemental Materials
Abstract
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