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2014
Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS.Schneider, RK, Ademà V., Heckl D., Järås M., Mallo M., Lord AM, Chu LP, McConkey ME, Kramann R., Mullally A., Bejar R., Solé F., and Ebert BL Cancer cell, 2014/09/17, (2014) Read More / View Supplemental Materials
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Pipeline for illumination correction of images for high-throughput microscopy.Singh, S., Bray MA, Jones TR, and Carpenter AE Journal of microscopy, 2014/09/16, (2014) Read More / View Supplemental Materials
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Sporulation during growth in a gut isolate of Bacillus subtilis.Serra, CR, Earl AM, Barbosa TM, Kolter R., and Henriques AO Journal of bacteriology, 2014/09/15, (2014) Read More / View Supplemental Materials
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TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Blood, 2014/09/15, (2014) Read More / View Supplemental Materials
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Nanoparticle vesicle encoding for imaging and tracking cell populations.Rees, P., Wills JW, Brown MR, Tonkin J., Holton MD, Hondow N., Brown AP, Brydson R., Millar V., Carpenter AE, and Summers HD Nature methods, 2014/09/14, (2014) Read More / View Supplemental Materials
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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak.Gire, SK, Goba A., Andersen KG, Sealfon RS, Park DJ, Kanneh L., Jalloh S., Momoh M., Fullah M., Dudas G., Wohl S., Moses LM, Yozwiak NL, Winnicki S., Matranga CB, Malboeuf CM, Qu J., Gladden AD, Schaffner SF, Yang X., et al. Science (New York, N.Y.), 2014/09/12, Volume 345, Issue 6202, p.1369-72, (2014) Read More / View Supplemental Materials
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Intersection of population variation and autoimmunity genetics in human T cell activation.Ye, CJ, Feng T., Kwon HK, Raj T., Wilson MT, Asinovski N., McCabe C., Lee MH, Frohlich I., Paik HI, Zaitlen N., Hacohen N., Stranger B., De Jager P., Mathis D., Regev A., and Benoist C. Science (New York, N.Y.), 2014/09/12, Volume 345, Issue 6202, p.1254665, (2014) Read More / View Supplemental Materials
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RNA Function. RNA and dynamic nuclear organization.Rinn, J., and Guttman M. Science (New York, N.Y.), 2014/09/12, Volume 345, Issue 6202, p.1240-1, (2014) Read More / View Supplemental Materials
Small-molecule control of cytokine function: new opportunities for treating immune disorders.Sundberg, TB, Xavier RJ, Schreiber SL, and Shamji AF Current opinion in chemical biology, 2014/09/12, Volume 23C, p.23-30, (2014) Read More / View Supplemental Materials
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Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.Wang, YH, Israelsen WJ, Lee D., Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, and Scadden DT Cell, 2014/09/11, Volume 158, Issue 6, p.1309-23, (2014) Read More / View Supplemental Materials
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Draft genome sequences of six enterohepatic helicobacter species isolated from humans and one from rhesus macaques.Shen, Z., Sheh A., Young SK, Abouelliel A., Ward DV, Earl AM, and Fox JG Genome announcements, 2014/09/11, Volume 2, Issue 5, (2014) Read More / View Supplemental Materials
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Effect of phosphodiesterase inhibition on insulin resistance in obese individuals.Ho, JE, Arora P., Walford GA, Ghorbani A., Guanaga DP, Dhakal BP, Nathan DI, Buys ES, Florez JC, Newton-Cheh C., Lewis GD, and Wang TJ Journal of the American Heart Association, 2014/09/11, Volume 3, Issue 5, (2014) Read More / View Supplemental Materials
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Gibbon genome and the fast karyotype evolution of small apes.Carbone, L., Harris RA, Gnerre S., Veeramah KR, Lorente-Galdos B., Huddleston J., Meyer TJ, Herrero J., Roos C., Aken B., Anaclerio F., Archidiacono N., Baker C., Barrell D., Batzer MA, Beal K., Blancher A., Bohrson CL, Brameier M., Campbell MS, et al. Nature, 2014/09/11, Volume 513, Issue 7517, p.195-201, (2014) Read More / View Supplemental Materials
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Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA.Schwartz, S., Bernstein DA, Mumbach MR, Jovanovic M., Herbst RH, León-Ricardo BX, Engreitz JM, Guttman M., Satija R., Lander E. S., Fink G., and Regev A. Cell, 2014/09/10, (2014) Read More / View Supplemental Materials
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The unconscionable gap between what we know and what we do.Hyman, SE Science translational medicine, 2014/09/10, Volume 6, Issue 253, p.253cm9, (2014) Read More / View Supplemental Materials
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Aspirin Should Be Discontinued After Lobar Intracerebral Hemorrhage.Falcone, GJ, and Rosand J. Stroke; a journal of cerebral circulation, 2014/09/09, (2014) Read More / View Supplemental Materials
Evaluation of compounds in primary human islet cell culture.Walpita, D., and Wagner BK Current protocols in chemical biology, 2014/09/09, Volume 6, Issue 3, p.157-68, (2014) Read More / View Supplemental Materials
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Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells.Ben-David, U., Arad G., Weissbein U., Mandefro B., Maimon A., Golan-Lev T., Narwani K., Clark AT, Andrews PW, Benvenisty N., and Carlos Biancotti J. Nature communications, 2014/09/08, Volume 5, p.4825, (2014) Read More / View Supplemental Materials
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Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.Rietveld, CA, Esko T., Davies G., Pers TH, Turley P., Benyamin B., Chabris CF, Emilsson V., Johnson AD, Lee JJ, de Leeuw C., Marioni RE, Medland SE, Miller MB, Rostapshova O., van der Lee SJ, Vinkhuyzen AA, Amin N., Conley D., Derringer J., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/09/08, (2014) Read More / View Supplemental Materials
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Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease: A Genome-Wide Association Study.Naj, AC, Jun G., Reitz C., Kunkle BW, Perry W., Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E., Barmada MM, et al. JAMA neurology, 2014/09/08, (2014) Read More / View Supplemental Materials
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GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.Broer, L., Buchman AS, Deelen J., Evans DS, Faul JD, Lunetta KL, Sebastiani P., Smith JA, Smith AV, Tanaka T., Yu L., Arnold AM, Aspelund T., Benjamin EJ, De Jager PL, Eirkisdottir G., Evans DA, Garcia ME, Hofman A., Kaplan RC, et al. The journals of gerontology. Series A, Biological sciences and medical sciences, 2014/09/08, (2014) Read More / View Supplemental Materials
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Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.Kumar, V., Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A., Giamarellos-Bourboulis E., Karjalainen J., Franke L., Withoff S., Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H., Bauer H., Herrmann BG, Bochud PY, Marchetti O., Perfect JR, Xavier RJ, et al. Nature communications, 2014/09/08, Volume 5, p.4675, (2014) Read More / View Supplemental Materials
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Genome-wide identification and characterization of functional neuronal activity-dependent enhancers.Malik, AN, Vierbuchen T., Hemberg M., Rubin AA, Ling E., Couch CH, Stroud H., Spiegel I., Farh KK, Harmin DA, and Greenberg ME Nature neuroscience, 2014/09/07, (2014) Read More / View Supplemental Materials
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The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera.Ahola, V., Lehtonen R., Somervuo P., Salmela L., Koskinen P., Rastas P., Välimäki N., Paulin L., Kvist J., Wahlberg N., Tanskanen J., Hornett EA, Ferguson LC, Luo S., Cao Z., de Jong MA, Duplouy A., Smolander OP, Vogel H., McCoy RC, et al. Nature communications, 2014/09/05, Volume 5, p.4737, (2014) Read More / View Supplemental Materials
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Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.Goldstein, JI, Fredrik Jarskog L., Hilliard C., Alfirevic A., Duncan L., Fourches D., Huang H., Lek M., Neale BM, Ripke S., Shianna K., Szatkiewicz JP, Tropsha A., van den Oord EJ, Cascorbi I., Dettling M., Gazit E., Goff DC, Holden AL, Kelly DL, et al. Nature communications, 2014/09/04, Volume 5, p.4757, (2014) Read More / View Supplemental Materials
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Association of exome sequences with plasma C-reactive protein levels in >9000 participants.Schick, UM, Auer PL, Bis JC, Lin H., Wei P., Pankratz N., Lange LA, Brody J., Stitziel NO, Kim DS, Carlson CS, Fornage M., Haessler J., Hsu L., Jackson RD, Kooperberg C., Leal SM, Psaty BM, Boerwinkle E., Tracy R., et al. Human molecular genetics, 2014/09/03, (2014) Read More / View Supplemental Materials
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The Genomic Landscape of Pediatric Ewing Sarcoma.Crompton, BD, Stewart C., Taylor-Weiner A., Alexe G., Kurek KC, Calicchio ML, Kiezun A., Carter SL, Shukla SA, Mehta SS, Thorner AR, de Torres C., Lavarino C., Sunol M., McKenna A., Sivachenko A., Cibulskis K., Lawrence MS, Stojanov P., Rosenberg M., et al. Cancer discovery, 2014/09/03, (2014) Read More / View Supplemental Materials
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The genomic substrate for adaptive radiation in African cichlid fish.Brawand, D., Wagner CE, Li YI, Malinsky M., Keller I., Fan S., Simakov O., Ng AY, Lim ZW, Bezault E., Turner-Maier J., Johnson J., Alcazar R., Noh HJ, Russell P., Aken B., Alföldi J., Amemiya C., Azzouzi N., Baroiller JF, et al. Nature, 2014/09/03, (2014) Read More / View Supplemental Materials
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Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.Doench, JG, Hartenian E., Graham DB, Tothova Z., Hegde M., Smith I., Sullender M., Ebert BL, Xavier RJ, and Root DE Nature biotechnology, 2014/09/03, (2014) Read More / View Supplemental Materials
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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.De Jager, PL, Srivastava G., Lunnon K., Burgess J., Schalkwyk LC, Yu L., Eaton ML, Keenan BT, Ernst J., McCabe C., Tang A., Raj T., Replogle J., Brodeur W., Gabriel S., Chai HS, Younkin C., Younkin SG, Zou F., Szyf M., et al. Nature neuroscience, 2014/09/01, Volume 17, Issue 9, p.1156-1163, (2014) Read More / View Supplemental Materials
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Computational pathology: an emerging definition.Louis, DN, Gerber GK, Baron JM, Bry L., Dighe AS, Getz G., Higgins JM, Kuo FC, Lane WJ, Michaelson JS, Le LP, Mermel CH, Gilbertson JR, and Golden JA Archives of pathology & laboratory medicine, 2014/09/01, Volume 138, Issue 9, p.1133-8, (2014) Read More / View Supplemental Materials
De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling.Del Vecchio, CA, Feng Y., Sokol ES, Tillman EJ, Sanduja S., Reinhardt F., and Gupta PB PLoS biology, 2014/09/01, Volume 12, Issue 9, p.e1001945, (2014) Read More / View Supplemental Materials
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Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease.Lunnon, K., Smith R., Hannon E., De Jager PL, Srivastava G., Volta M., Troakes C., Al-Sarraj S., Burrage J., Macdonald R., Condliffe D., Harries LW, Katsel P., Haroutunian V., Kaminsky Z., Joachim C., Powell J., Lovestone S., Bennett DA, Schalkwyk LC, et al. Nature neuroscience, 2014/09/01, Volume 17, Issue 9, p.1164-1170, (2014) Read More / View Supplemental Materials
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Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.Hill, SJ, Rolland T., Adelmant G., Xia X., Owen MS, Dricot A., Zack TI, Sahni N., Jacob Y., Hao T., McKinney KM, Clark AP, Reyon D., Tsai SQ, Joung JK, Beroukhim R., Marto JA, Vidal M., Gaudet S., Hill DE, et al. Genes & development, 2014/09/01, Volume 28, Issue 17, p.1957-75, (2014) Read More / View Supplemental Materials
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Toward a new history and geography of human genes informed by ancient DNA.Pickrell, JK, and Reich D. Trends in genetics : TIG, 2014/09/01, Volume 30, Issue 9, p.377-389, (2014) Read More / View Supplemental Materials
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Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication.Carneiro, M., Rubin CJ, Di Palma F., Albert FW, Alföldi J., Barrio AM, Pielberg G., Rafati N., Sayyab S., Turner-Maier J., Younis S., Afonso S., Aken B., Alves JM, Barrell D., Bolet G., Boucher S., Burbano HA, Campos R., Chang JL, et al. Science (New York, N.Y.), 2014/08/29, Volume 345, Issue 6200, p.1074-9, (2014) Read More / View Supplemental Materials
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Comparative analysis of metazoan chromatin organization.Ho, JW, Jung YL, Liu T., Alver BH, Lee S., Ikegami K., Sohn KA, Minoda A., Tolstorukov MY, Appert A., Parker SC, Gu T., Kundaje A., Riddle NC, Bishop E., Egelhofer TA, Hu SS, Alekseyenko AA, Rechtsteiner A., Asker D., et al. Nature, 2014/08/28, Volume 512, Issue 7515, p.449-52, (2014) Read More / View Supplemental Materials
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Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.Shaul, YD, Freinkman E., Comb WC, Cantor JR, Tam WL, Thiru P., Kim D., Kanarek N., Pacold ME, Chen WW, Bierie B., Possemato R., Reinhardt F., Weinberg R. A., Yaffe MB, and Sabatini DM Cell, 2014/08/28, Volume 158, Issue 5, p.1094-109, (2014) Read More / View Supplemental Materials
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Guided visual exploration of genomic stratifications in cancer.Streit, M., Lex A., Gratzl S., Partl C., Schmalstieg D., Pfister H., Park PJ, and Gehlenborg N. Nature methods, 2014/08/28, Volume 11, Issue 9, p.884-5, (2014) Read More / View Supplemental Materials
Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease.Tada, H., Won HH, Melander O., Yang J., Peloso GM, and Kathiresan S. Circulation. Cardiovascular genetics, 2014/08/28, (2014) Read More / View Supplemental Materials
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The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations.Keane, M., Craig T., Alföldi J., Berlin AM, Johnson J., Seluanov A., Gorbunova V., Di Palma F., Lindblad-Toh K., Church GM, and de Magalhães JP Bioinformatics (Oxford, England), 2014/08/28, (2014) Read More / View Supplemental Materials
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Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality.Jerby-Arnon, L., Pfetzer N., Waldman YY, McGarry L., James D., Shanks E., Seashore-Ludlow B., Weinstock A., Geiger T., Clemons PA, Gottlieb E., and Ruppin E. Cell, 2014/08/28, Volume 158, Issue 5, p.1199-209, (2014) Read More / View Supplemental Materials
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Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness.Wang, JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, and Perlis RH Translational psychiatry, 2014/08/26, Volume 4, p.e428, (2014) Read More / View Supplemental Materials
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Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.Majithia, AR, Flannick J., Shahinian P., Guo M., Bray MA, Fontanillas P., Gabriel SB, GoT2D Consortium, NHGRI JHS/FHS Allelic Spectrum Project, SIGMA T2D Consortium, T2D-GENES Consortium, Rosen ED, Altshuler D., and GoT2D Consortium Proceedings of the National Academy of Sciences of the United States of America, 2014/08/25, (2014) Read More / View Supplemental Materials
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Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation.Andresen, L., Hampton D., Taylor A., Morel L., Yang Y., Maguire J., and Dulla CG Neurobiology of disease, 2014/08/23, (2014) Read More / View Supplemental Materials
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APOE ε variants increase risk of warfarin-related intracerebral hemorrhage.Falcone, GJ, Radmanesh F., Brouwers HB, Battey TW, Devan WJ, Valant V., Raffeld MR, Chitsike LP, Ayres AM, Schwab K., Goldstein JN, Viswanathan A., Greenberg SM, Selim M., Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Flaherty ML, et al. Neurology, 2014/08/22, (2014) Read More / View Supplemental Materials
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Cosi2 : An efficient simulator of exact and approximate coalescent with selection.Shlyakhter, I., Sabeti PC, and Schaffner SF Bioinformatics (Oxford, England), 2014/08/22, (2014) Read More / View Supplemental Materials
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ProtocolNavigator: emulation based software for the design, documentation and reproduction biological experiments.Khan, IA, Fraser A., Bray MA, Smith PJ, White NS, Carpenter AE, and Errington RJ Bioinformatics (Oxford, England), 2014/08/22, (2014) Read More / View Supplemental Materials
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Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.Fox, IJ, Daley GQ, Goldman SA, Huard J., Kamp TJ, and Trucco M. Science (New York, N.Y.), 2014/08/22, Volume 345, Issue 6199, p.1247391, (2014) Read More / View Supplemental Materials
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Multivariate inference of pathway activity in host immunity and response to therapeutics.Goel, G., Conway KL, Jaeger M., Netea MG, and Xavier RJ Nucleic acids research, 2014/08/21, (2014) Read More / View Supplemental Materials
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PyBamView: a browser based application for viewing short read alignments.Gymrek, M. Bioinformatics (Oxford, England), 2014/08/21, (2014) Read More / View Supplemental Materials
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Somatic Mutations in Cerebral Cortical Malformations.Jamuar, SS, Lam AT, Kircher M., D'Gama AM, Wang J., Barry BJ, Zhang X., Hill RS, Partlow JN, Rozzo A., Servattalab S., Mehta BK, Topcu M., Amrom D., Andermann E., Dan B., Parrini E., Guerrini R., Scheffer IE, Berkovic SF, et al. The New England journal of medicine, 2014/08/21, Volume 371, Issue 8, p.733-743, (2014) Read More / View Supplemental Materials
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Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain.Cai, X., Evrony GD, Lehmann HS, Elhosary PC, Mehta BK, Poduri A., and Walsh CA Cell reports, 2014/08/20, (2014) Read More / View Supplemental Materials
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The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma.Davis, CF, Ricketts CJ, Wang M., Yang L., Cherniack AD, Shen H., Buhay C., Kang H., Kim SC, Fahey CC, Hacker KE, Bhanot G., Gordenin DA, Chu A., Gunaratne PH, Biehl M., Seth S., Kaipparettu BA, Bristow CA, Donehower LA, et al. Cancer cell, 2014/08/20, (2014) Read More / View Supplemental Materials
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DNA replication timing: Coordinating genome stability with genome regulation on the X chromosome and beyond.Koren, A. BioEssays : news and reviews in molecular, cellular and developmental biology, 2014/08/19, (2014) Read More / View Supplemental Materials
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Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma.Moore, NF, Azarova AM, Bhatnagar N., Ross KN, Drake LE, Frumm S., Liu QS, Christie AL, Sanda T., Chesler L., Kung AL, Gray NS, Stegmaier K., and George RE Oncotarget, 2014/08/19, (2014) Read More / View Supplemental Materials
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Reconstructing Austronesian population history in Island Southeast Asia.Lipson, M., Loh PR, Patterson N., Moorjani P., Ko YC, Stoneking M., Berger B., and Reich D. Nature communications, 2014/08/19, Volume 5, p.4689, (2014) Read More / View Supplemental Materials
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Genomic instability, driver genes and cell selection: Projections from cancer to stem cells.Ben-David, U. Biochimica et biophysica acta, 2014/08/15, (2014) Read More / View Supplemental Materials
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Integrating Genetic, Transcriptional, and Functional Analyses to Identify Five Novel Genes for Atrial Fibrillation.Sinner, MF, Tucker NR, Lunetta KL, Ozaki K., Smith JG, Trompet S., Bis JC, Lin H., Chung MK, Nielsen JB, Lubitz SA, Krijthe BP, Magnani JW, Ye J., Gollob MH, Tsunoda T., Müller-Nurasyid M., Lichtner P., Peters A., Dolmatova E., et al. Circulation, 2014/08/14, (2014) Read More / View Supplemental Materials
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Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin.Hoadley, KA, Yau C., Wolf DM, Cherniack AD, Tamborero D., Ng S., Leiserson MD, Niu B., McLellan MD, Uzunangelov V., Zhang J., Kandoth C., Akbani R., Shen H., Omberg L., Chu A., Margolin AA, Van't Veer LJ, Lopez-Bigas N., Laird PW, et al. Cell, 2014/08/14, Volume 158, Issue 4, p.929-44, (2014) Read More / View Supplemental Materials
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Twelve-Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke.Tada, H., Shiffman D., Smith JG, Sjögren M., Lubitz SA, Ellinor PT, Louie JZ, Catanese JJ, Engström G., Devlin JJ, Kathiresan S., and Melander O. Stroke; a journal of cerebral circulation, 2014/08/14, (2014) Read More / View Supplemental Materials
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Polyoma Small T Antigen Interacts with YES-Associated Protein (YAP) to Regulate Cell Survival and Differentiation.Hwang, JH, Pores Fernando AT, Faure N., Andrabi S., Hahn WC, Schaffhausen BS, and Roberts TM Journal of virology, 2014/08/13, (2014) Read More / View Supplemental Materials
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An alteration in ATG16L1 stability in Crohn disease.Lassen, KG, and Xavier RJ Autophagy, 2014/08/12, Volume 10, Issue 10, (2014) Read More / View Supplemental Materials
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Testing the accuracy of an observation-based classifier for rapid detection of autism risk.Duda, M., Kosmicki JA, and Wall DP Translational psychiatry, 2014/08/12, Volume 4, p.e424, (2014) Read More / View Supplemental Materials
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Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.Sundberg, TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B., Gagnon J., O'Connell DJ, Narayan K., Dančík V., Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, and Shamji AF Proceedings of the National Academy of Sciences of the United States of America, 2014/08/11, (2014) Read More / View Supplemental Materials
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Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum.Wagner, JC, Platt RJ, Goldfless SJ, Zhang F., and Niles JC Nature methods, 2014/08/10, (2014) Read More / View Supplemental Materials
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Genome-wide association analyses identify variants in developmental genes associated with hypospadias.Geller, F., Feenstra B., Carstensen L., Pers TH, van Rooij IA, Körberg IB, Choudhry S., Karjalainen JM, Schnack TH, Hollegaard MV, Feitz WF, Roeleveld N., Hougaard DM, Hirschhorn JN, Franke L., Baskin LS, Nordenskjöld A., van der Zanden LF, and Melbye M. Nature genetics, 2014/08/10, (2014) Read More / View Supplemental Materials
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Fast construction of FM-index for long sequence reads.Li, H. Bioinformatics (Oxford, England), 2014/08/08, (2014) Read More / View Supplemental Materials
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Molecular pathogenesis of congenital diaphragmatic hernia revealed by exome sequencing, developmental data, and bioinformatics.Longoni, M., High FA, Russell MK, Kashani A., Tracy AA, Coletti CM, Hila R., Shamia A., Wells J., Ackerman KG, Wilson JM, Bult CJ, Lee C., Lage K., Pober BR, and Donahoe PK Proceedings of the National Academy of Sciences of the United States of America, 2014/08/08, (2014) Read More / View Supplemental Materials
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Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.Okada, Y., Han B., Tsoi LC, Stuart PE, Ellinghaus E., Tejasvi T., Chandran V., Pellett F., Pollock R., Bowcock AM, Krueger GG, Weichenthal M., Voorhees JJ, Rahman P., Gregersen PK, Franke A., Nair RP, Abecasis GR, Gladman DD, Elder JT, et al. American journal of human genetics, 2014/08/07, Volume 95, Issue 2, p.162-72, (2014) Read More / View Supplemental Materials
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CRISPR-mediated direct mutation of cancer genes in the mouse liver.Xue, W., Chen S., Yin H., Tammela T., Papagiannakopoulos T., Joshi NS, Cai W., Yang G., Bronson R., Crowley DG, Zhang F., Anderson DG, Sharp PA, and Jacks T. Nature, 2014/08/06, (2014) Read More / View Supplemental Materials
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Genetic validation of a therapeutic target in a mouse model of ALS.de Boer, AS, Koszka K., Kiskinis E., Suzuki N., Davis-Dusenbery BN, and Eggan K. Science translational medicine, 2014/08/06, Volume 6, Issue 248, p.248ra104, (2014) Read More / View Supplemental Materials
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Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1.Nichols, B., Jog P., Lee JH, Blackler D., Wilmot M., D'Agati V., Markowitz G., Kopp JB, Alper SL, Pollak MR, and Friedman DJ Kidney international, 2014/08/06, (2014) Read More / View Supplemental Materials
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A lesson in communication.Dahlman, JE Nature nanotechnology, 2014/08/05, Volume 9, Issue 8, p.656, (2014) Read More / View Supplemental Materials
Microfluidic organs-on-chips.Bhatia, SN, and Ingber DE Nature biotechnology, 2014/08/05, Volume 32, Issue 8, p.760-72, (2014) Read More / View Supplemental Materials
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Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems.Shlomai, A., Schwartz RE, Ramanan V., Bhatta A., de Jong YP, Bhatia SN, and Rice CM Proceedings of the National Academy of Sciences of the United States of America, 2014/08/04, (2014) Read More / View Supplemental Materials
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Somatic Mutations Predict Poor Outcome in Patients With Myelodysplastic Syndrome After Hematopoietic Stem-Cell Transplantation.Bejar, R., Stevenson KE, Caughey B., Lindsley RC, Mar BG, Stojanov P., Getz G., Steensma DP, Ritz J., Soiffer R., Antin JH, Alyea E., Armand P., Ho V., Koreth J., Neuberg D., Cutler CS, and Ebert BL Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014/08/04, (2014) Read More / View Supplemental Materials
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A framework for the interpretation of de novo mutation in human disease.Samocha, KE, Robinson EB, Sanders SJ, Stevens C., Sabo A., McGrath LM, Kosmicki JA, Rehnström K., Mallick S., Kirby A., Wall DP, Macarthur DG, Gabriel SB, DePristo M., Purcell SM, Palotie A., Boerwinkle E., Buxbaum JD, Cook EH Jr, Gibbs RA, et al. Nature genetics, 2014/08/03, (2014) Read More / View Supplemental Materials
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Fungi on the Skin: Dermatophytes and Malassezia.White, TC, Findley K., Dawson TL Jr, Scheynius A., Boekhout T., Cuomo CA, Xu J., and Saunders CW Cold Spring Harbor perspectives in medicine, 2014/08/01, Volume 4, Issue 8, (2014) Read More / View Supplemental Materials
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A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.Bachovchin, DA, Koblan LW, Wu W., Liu Y., Li Y., Zhao P., Woznica I., Shu Y., Lai JH, Poplawski SE, Kiritsy CP, Healey SE, DiMare M., Sanford DG, Munford RS, Bachovchin WW, and Golub T. R. Nature chemical biology, 2014/08/01, Volume 10, Issue 8, p.656-63, (2014) Read More / View Supplemental Materials
Abstract
Metformin pharmacogenomics: current status and future directions.Pawlyk, AC, Giacomini KM, McKeon C., Shuldiner AR, and Florez JC Diabetes, 2014/08/01, Volume 63, Issue 8, p.2590-9, (2014) Read More / View Supplemental Materials
Abstract
Notch inhibition allows oncogene-independent generation of iPS cells.Ichida, JK, T C W J., Williams LA, Carter AC, Shi Y., Moura MT, Ziller M., Singh S., Amabile G., Bock C., Umezawa A., Rubin LL, Bradner JE, Akutsu H., Meissner A., and Eggan K. Nature chemical biology, 2014/08/01, Volume 10, Issue 8, p.632-9, (2014) Read More / View Supplemental Materials
Abstract
Role of BRAFV600E in the First Preclinical Model of Multifocal Infiltrating Myopericytoma Development and Microenvironment.Sadow, PM, Priolo C., Nanni S., Karreth FA, Duquette M., Martinelli R., Husain A., Clohessy J., Kutzner H., Mentzel T., Carman CV, Farsetti A., Henske EP, Palescandolo E., Macconaill LE, Chung S., Fadda G., Lombardi CP, De Angelis AM, Durante O., et al. Journal of the National Cancer Institute, 2014/08/01, Volume 106, Issue 8, (2014) Read More / View Supplemental Materials
Abstract
Single cell RNA-Seq of hematopoietic stem cells reveals a cell cycle-dependent interplay between aging and differentiation.Kowalczyk, M., Tirosh I., Heckl D., Ebert B., and Regev A. Experimental hematology, 2014/08/01, Volume 42, Issue 8 Suppl, p.S21, (2014) Read More / View Supplemental Materials
The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis.McAllister, SS, and Weinberg R. A. Nature cell biology, 2014/08/01, Volume 16, Issue 8, p.717-27, (2014) Read More / View Supplemental Materials
Abstract
The upside of failure: how regional student groups learn from their mistakes.Mishra, T., Parra RG, and Abeel T. PLoS computational biology, 2014/08/01, Volume 10, Issue 8, p.e1003768, (2014) Read More / View Supplemental Materials
Abstract
DNA methylation dynamics of the human preimplantation embryo.Smith, ZD, Chan MM, Humm KC, Karnik R., Mekhoubad S., Regev A., Eggan K., and Meissner A. Nature, 2014/07/31, Volume 511, Issue 7511, p.611-5, (2014) Read More / View Supplemental Materials
Abstract
Genome Sequence of Fusarium oxysporum f. sp. melonis Strain NRRL 26406, a Fungus Causing Wilt Disease on Melon.Ma, LJ, Shea T., Young S., Zeng Q., and Kistler HC Genome announcements, 2014/07/31, Volume 2, Issue 4, (2014) Read More / View Supplemental Materials
Abstract
Functional variations modulating PRKCA expression and alternative splicing predispose to multiple sclerosis.Paraboschi, EM, Rimoldi V., Soldà G., Tabaglio T., Dall'Osso C., Saba E., Vigliano M., Salviati A., Leone M., Benedetti MD, Fornasari D., Saarela J., De Jager P., Patsopoulos NA, D'Alfonso S., Gemmati D., Duga S., and Asselta R. Human molecular genetics, 2014/07/30, (2014) Read More / View Supplemental Materials
Abstract
Improved vectors and genome-wide libraries for CRISPR screening.Sanjana, NE, Shalem O., and Zhang F. Nature methods, 2014/07/30, Volume 11, Issue 8, p.783-4, (2014) Read More / View Supplemental Materials
Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity.Marusyk, A., Tabassum DP, Altrock PM, Almendro V., Michor F., and Polyak K. Nature, 2014/07/30, (2014) Read More / View Supplemental Materials
Abstract
Highly Recombinant VGII Cryptococcus gattii Population Develops Clonal Outbreak Clusters through both Sexual Macroevolution and Asexual Microevolution.Billmyre, RB, Croll D., Li W., Mieczkowski P., Carter DA, Cuomo CA, Kronstad JW, and Heitman J. mBio, 2014/07/29, Volume 5, Issue 4, (2014) Read More / View Supplemental Materials
Abstract
Early remodeling of the neocortex upon episodic memory encoding.Bero, AW, Meng J., Cho S., Shen AH, Canter RG, Ericsson M., and Tsai LH Proceedings of the National Academy of Sciences of the United States of America, 2014/07/28, (2014) Read More / View Supplemental Materials
Abstract
Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations.Okada, Y., Kim K., Han B., Pillai NE, Ong RT, Saw WY, Luo M., Jiang L., Yin J., Bang SY, Lee HS, Brown MA, Bae SC, Xu H., Teo YY, de Bakker PI, and Raychaudhuri S. Human molecular genetics, 2014/07/28, (2014) Read More / View Supplemental Materials
Abstract
Describing the genetic architecture of epilepsy through heritability analysis.Speed, D., O'Brien TJ, Palotie A., Shkura K., Marson AG, Balding DJ, and Johnson MR Brain : a journal of neurology, 2014/07/26, (2014) Read More / View Supplemental Materials
Abstract
Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.Lamming, DW, Mihaylova MM, Katajisto P., Baar EL, Yilmaz OH, Hutchins A., Gultekin Y., Gaither R., and Sabatini DM Aging cell, 2014/07/25, (2014) Read More / View Supplemental Materials
Abstract
CC2D1A Regulates Human Intellectual and Social Function as well as NF-κB Signaling Homeostasis.Manzini, MC, Xiong L., Shaheen R., Tambunan DE, Di Costanzo S., Mitisalis V., Tischfield DJ, Cinquino A., Ghaziuddin M., Christian M., Jiang Q., Laurent S., Nanjiani ZA, Rasheed S., Hill RS, Lizarraga SB, Gleason D., Sabbagh D., Salih MA, Alkuraya FS, et al. Cell reports, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.Seiwert, TY, Zuo Z., Keck MK, Khattri A., Pedamallu CS, Stricker TP, Brown CD, Pugh TJ, Stojanov P., Cho J., Lawrence M., Getz G., Bragelmann J., DeBoer R., Weichselbaum RR, Langerman A., Portugal LD, Blair EA, Stenson KM, Lingen MW, et al. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis.Wivagg, CN, Bhattacharyya RP, and Hung DT The Journal of antibiotics, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.Ramos, YF, Metrustry S., Arden N., Bay-Jensen AC, Beekman M., de Craen AJ, Cupples LA, Esko T., Evangelou E., Felson DT, Hart DJ, Ioannidis JP, Karsdal M., Kloppenburg M., Lafeber F., Metspalu A., Panoutsopoulou K., Slagboom PE, Spector TD, van Spil EW, et al. Journal of medical genetics, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
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