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2014
SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.Fowler, SA, Ananthakrishnan AN, Gardet A., Stevens CR, Korzenik JR, Sands BE, Daly M. J., Xavier RJ, and Yajnik V. Journal of Crohn's & colitis, 2014/01/22, (2014) Read More / View Supplemental Materials
Abstract
Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21.Hamrefors, V., Hedblad B., Hindy G., Smith JG, Almgren P., Engström G., Sjögren M., Gränsbo K., Orho-Melander M., and Melander O. PloS one, 2014/01/22, Volume 9, Issue 1, p.e85893, (2014) Read More / View Supplemental Materials
Abstract
In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene.Dunn, GP, Cheung HW, Agarwalla PK, Thomas S., Zektser Y., Karst AM, Boehm JS, Weir BA, Berlin AM, Zou L., Getz G., Liu JF, Hirsch M., Vazquez F., Root DE, Beroukhim R., Drapkin R., and Hahn WC Proceedings of the National Academy of Sciences of the United States of America, 2014/01/21, Volume 111, Issue 3, p.1102-7, (2014) Read More / View Supplemental Materials
Abstract
Inference of Tumor Evolution during Chemotherapy by Computational Modeling and In Situ Analysis of Genetic and Phenotypic Cellular Diversity.Almendro, V., Cheng YK, Randles A., Itzkovitz S., Marusyk A., Ametller E., Gonzalez-Farre X., Muñoz M., Russnes HG, Helland A., Rye IH, Borresen-Dale AL, Maruyama R., van Oudenaarden A., Dowsett M., Jones RL, Reis-Filho J., Gascon P., Gönen M., Michor F., et al. Cell reports, 2014/01/21, (2014) Read More / View Supplemental Materials
Abstract
Strength in numbers: comparing vaccine signatures the modular way.Haining, WN Nature immunology, 2014/01/21, Volume 15, Issue 2, p.139-41, (2014) Read More / View Supplemental Materials
Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.Zhu, Z., Aref AR, Cohoon TJ, Barbie TU, Imamura Y., Yang S., Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P., Godfrey JT, Qian ZR, Page AN, Maciag K., Chan EM, Silkworth W., Labowsky MT, Rozhansky L., et al. Cancer discovery, 2014/01/20, (2014) Read More / View Supplemental Materials
Abstract
Rare Copy Number Variation in Treatment-Resistant Major Depressive Disorder.O'Dushlaine, C., Ripke S., Ruderfer DM, Hamilton SP, Fava M., Iosifescu DV, Kohane IS, Churchill SE, Castro VM, Clements CC, Blumenthal SR, Murphy SN, Smoller JW, and Perlis RH Biological psychiatry, 2014/01/19, (2014) Read More / View Supplemental Materials
Abstract
The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated with Panic Disorder and Amygdala Structure and Function.Smoller, JW, Gallagher PJ, Duncan LE, McGrath LM, Haddad SA, Holmes AJ, Wolf AB, Hilker S., Block SR, Weill S., Young S., Choi EY, Rosenbaum JF, Biederman J., Faraone SV, Roffman JL, Manfro GG, Blaya C., Hirshfeld-Becker DR, Stein MB, et al. Biological psychiatry, 2014/01/18, (2014) Read More / View Supplemental Materials
Abstract
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.Krönke, J., Udeshi ND, Narla A., Grauman P., Hurst SN, McConkey M., Svinkina T., Heckl D., Comer E., Li X., Ciarlo C., Hartman E., Munshi N., Schenone M., Schreiber SL, Carr SA, and Ebert BL Science (New York, N.Y.), 2014/01/17, Volume 343, Issue 6168, p.301-5, (2014) Read More / View Supplemental Materials
Abstract
Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories.Gräff, J., Joseph NF, Horn ME, Samiei A., Meng J., Seo J., Rei D., Bero AW, Phan TX, Wagner F., Holson E., Xu J., Sun J., Neve RL, Mach RH, Haggarty SJ, and Tsai LH Cell, 2014/01/16, Volume 156, Issue 1-2, p.261-76, (2014) Read More / View Supplemental Materials
Abstract
A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility.Damotte, V., Guillot-Noel L., Patsopoulos NA, Madireddy L., El Behi M., International Multiple Sclerosis Genetics Consortium, Ban M., Baranzini S., Barcellos L., Beecham G., Beecham A., Bernardinelli L., Booth D., Bos S., Buck D., Bush W., Comabella M., Compston A., Cotsapas C., Cournu-Rebeix I., et al. Genes and immunity, 2014/01/16, (2014) Read More / View Supplemental Materials
Abstract
The multilayered complexity of ceRNA crosstalk and competition.Tay, Y., Rinn J., and Pandolfi PP Nature, 2014/01/16, Volume 505, Issue 7483, p.344-52, (2014) Read More / View Supplemental Materials
Abstract
Multilocus Genetic Risk Score Associates With Ischemic Stroke in Case-Control and Prospective Cohort Studies.Malik, R., Bevan S., Nalls MA, Holliday EG, Devan WJ, Cheng YC, Ibrahim-Verbaas CA, Verhaaren BF, Bis JC, Joon AY, Destefano AL, Fornage M., Psaty BM, Ikram MA, Launer LJ, van Duijn CM, Sharma P., Mitchell BD, Rosand J., Meschia JF, et al. Stroke; a journal of cerebral circulation, 2014/01/16, (2014) Read More / View Supplemental Materials
Abstract
Predicting Stroke Through Genetic Risk Functions: The CHARGE Risk Score Project.Ibrahim-Verbaas, CA, Fornage M., Bis JC, Choi SH, Psaty BM, Meigs JB, Rao M., Nalls M., Fontes JD, O'Donnell CJ, Kathiresan S., Ehret GB, Fox CS, Malik R., Dichgans M., Schmidt H., Lahti J., Heckbert SR, Lumley T., Rice K., et al. Stroke; a journal of cerebral circulation, 2014/01/16, (2014) Read More / View Supplemental Materials
Abstract
Regulation of Ferroptotic Cancer Cell Death by GPX4.Yang, WS, Sriramaratnam R., Welsch ME, Shimada K., Skouta R., Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, and Stockwell BR Cell, 2014/01/16, Volume 156, Issue 1-2, p.317-31, (2014) Read More / View Supplemental Materials
Abstract
What we talk about when we talk about fat.Rosen, ED, and Spiegelman BM Cell, 2014/01/16, Volume 156, Issue 1-2, p.20-44, (2014) Read More / View Supplemental Materials
Abstract
Insights from monogenic diabetes and glycemic treatment goals for common types of diabetes.Florez, JC JAMA : the journal of the American Medical Association, 2014/01/15, Volume 311, Issue 3, p.249-51, (2014) Read More / View Supplemental Materials
Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance.Kats, LM, Reschke M., Taulli R., Pozdnyakova O., Burgess K., Bhargava P., Straley K., Karnik R., Meissner A., Small D., Su SM, Yen K., Zhang J., and Pandolfi PP Cell stem cell, 2014/01/15, (2014) Read More / View Supplemental Materials
Abstract
ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State.Chudnovsky, Y., Kim D., Zheng S., Whyte WA, Bansal M., Bray MA, Gopal S., Theisen MA, Bilodeau S., Thiru P., Muffat J., Yilmaz OH, Mitalipova M., Woolard K., Lee J., Nishimura R., Sakata N., Fine HA, Carpenter AE, Silver SJ, et al. Cell reports, 2014/01/15, (2014) Read More / View Supplemental Materials
Abstract
Autophagy is essential for cardiac morphogenesis during vertebrate development.Lee, E., Koo Y., Ng A., Wei Y., Luby-Phelps K., Juraszek A., Xavier RJ, Cleaver O., Levine B., and Amatruda JF Autophagy, 2014/01/14, Volume 10, Issue 4, (2014) Read More / View Supplemental Materials
Abstract
Differential Effect of Genetic Burden on Disease Phenotypes in Crohn's Disease and Ulcerative Colitis: Analysis of a North American Cohort.Ananthakrishnan, AN, Huang H., Nguyen DD, Sauk J., Yajnik V., and Xavier RJ The American journal of gastroenterology, 2014/01/14, (2014) Read More / View Supplemental Materials
Abstract
Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance.Lukens, AK, Ross LS, Heidebrecht R., Javier Gamo F., Lafuente-Monasterio MJ, Booker ML, Hartl DL, Wiegand RC, and Wirth DF Proceedings of the National Academy of Sciences of the United States of America, 2014/01/14, Volume 111, Issue 2, p.799-804, (2014) Read More / View Supplemental Materials
Abstract
De novo fatty acid synthesis at the mitotic exit is required to complete cellular division.Scaglia, N., Tyekucheva S., Zadra G., Photopoulos C., and Loda M. Cell cycle (Georgetown, Tex.), 2014/01/13, Volume 13, Issue 5, (2014) Read More / View Supplemental Materials
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Using transcription of six Puccinia triticina races to identify the effective secretome during infection of wheat.Bruce, M., Neugebauer KA, Joly DL, Migeon P., Cuomo CA, Wang S., Akhunov E., Bakkeren G., Kolmer JA, and Fellers JP Frontiers in plant science, 2014/01/13, Volume 4, p.520, (2014) Read More / View Supplemental Materials
Abstract
Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.Lohr, JG, Stojanov P., Carter SL, Cruz-Gordillo P., Lawrence MS, Auclair D., Sougnez C., Knoechel B., Gould J., Saksena G., Cibulskis K., McKenna A., Chapman MA, Straussman R., Levy J., Perkins LM, Keats JJ, Schumacher SE, Rosenberg M., Multiple Myeloma Research Consortium, et al. Cancer cell, 2014/01/13, Volume 25, Issue 1, p.91-101, (2014) Read More / View Supplemental Materials
Abstract
Common Variation in Fatty Acid Metabolic Genes and Risk of Incident Sudden Cardiac Arrest.Lemaitre, RN, Johnson CO, Hesselson S., Sotoodhenia N., McKnight B., Sitlani CM, Rea TD, King IB, Kwok PY, Mak A., Li G., Brody J., Larson E., Mozaffarian D., Psaty BM, Huertas-Vazquez A., Tardif JC, Albert CM, Lyytikäinen LP, Arking DE, et al. Heart rhythm : the official journal of the Heart Rhythm Society, 2014/01/10, (2014) Read More / View Supplemental Materials
Abstract
β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors.Roberts, LD, Boström P., O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A., Lee YK, Palma MJ, Calhoun S., Georgiadi A., Chen MH, Ramachandran VS, Larson MG, Bouchard C., Rankinen T., Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, et al. Cell metabolism, 2014/01/07, Volume 19, Issue 1, p.96-108, (2014) Read More / View Supplemental Materials
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Discovery and saturation analysis of cancer genes across 21 tumour types.Lawrence, MS, Stojanov P., Mermel CH, Robinson JT, Garraway LA, Golub T. R., Meyerson M., Gabriel SB, Lander E. S., and Getz G. Nature, 2014/01/05, (2014) Read More / View Supplemental Materials
Abstract
Genome-scale CRISPR-Cas9 knockout screening in human cells.Shalem, O., Sanjana NE, Hartenian E., Shi X., Scott DA, Mikkelsen TS, Heckl D., Ebert BL, Root DE, Doench JG, and Zhang F. Science (New York, N.Y.), 2014/01/03, Volume 343, Issue 6166, p.84-7, (2014) Read More / View Supplemental Materials
Abstract
The complete genome sequence of a Neanderthal from the Altai Mountains.Prüfer, K., Racimo F., Patterson N., Jay F., Sankararaman S., Sawyer S., Heinze A., Renaud G., Sudmant PH, de Filippo C., Li H., Mallick S., Dannemann M., Fu Q., Kircher M., Kuhlwilm M., Lachmann M., Meyer M., Ongyerth M., Siebauer M., et al. Nature, 2014/01/02, Volume 505, Issue 7481, p.43-9, (2014) Read More / View Supplemental Materials
Abstract
The influence of polygenic risk scores on heritability of anti-CCP level in RA.Cui, J., Taylor KE, Lee YC, Källberg H., Weinblatt ME, Coblyn JS, Klareskog L., Criswell LA, Gregersen PK, Shadick NA, Plenge RM, and Karlson EW Genes and immunity, 2014/01/02, (2014) Read More / View Supplemental Materials
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Mutations in CSPP1 Lead to Classical Joubert Syndrome.Akizu, N., Silhavy JL, Rosti RO, Scott E., Fenstermaker AG, Schroth J., Zaki MS, Sanchez H., Gupta N., Kabra M., Kara M., Ben-Omran T., Rosti B., Guemez-Gamboa A., Spencer E., Pan R., Cai N., Abdellateef M., Gabriel S., Halbritter J., et al. American journal of human genetics, 2014/01/02, Volume 94, Issue 1, p.80-6, (2014) Read More / View Supplemental Materials
Abstract
Probiotic microbes sustain youthful serum testosterone levels and testicular size in aging mice.Poutahidis, T., Springer A., Levkovich T., Qi P., Varian BJ, Lakritz JR, Ibrahim YM, Chatzigiagkos A., Alm EJ, and Erdman SE PloS one, 2014/01/02, Volume 9, Issue 1, p.e84877, (2014) Read More / View Supplemental Materials
Abstract
An Adjustable Gas-Mixing Device to Increase Feasibility of In Vitro Culture of Plasmodium falciparum Parasites in the Field.Bei, AK, Patel SD, Volkman SK, Ahouidi AD, Ndiaye D., Mboup S., and Wirth DF PloS one, 2014/01/01, Volume 9, Issue 3, p.e90928, (2014) Read More / View Supplemental Materials
Abstract
Comorbidity of Severe Psychotic Disorders With Measures of Substance Use.Hartz, SM, Pato CN, Medeiros H., Cavazos-Rehg P., Sobell JL, Knowles JA, Bierut LJ, Pato MT, for the Genomic Psychiatry Cohort Consortium, Abbott C., Azevedo MH, Belliveau R., Bevilacqua E., Bromet EJ, Buckley PF, Dewan MJ, Escamilla MA, Fanous AH, Fochtmann LJ, Kinkead R., et al. JAMA psychiatry, 2014/01/01, (2014) Read More / View Supplemental Materials
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Comparison of illumina and 454 deep sequencing in participants failing raltegravir-based antiretroviral therapy.Li, JZ, Chapman B., Charlebois P., Hofmann O., Weiner B., Porter AJ, Samuel R., Vardhanabhuti S., Zheng L., Eron J., Taiwo B., Zody MC, Henn MR, Kuritzkes DR, Hide W., ACTG A5262 Study Team, Wilson CC, Berzins BI, Acosta EP, Bastow B., et al. PloS one, 2014/01/01, Volume 9, Issue 3, p.e90485, (2014) Read More / View Supplemental Materials
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Comprehensive functional annotation of 77 prostate cancer risk Loci.Hazelett, DJ, Rhie SK, Gaddis M., Yan C., Lakeland DL, Coetzee SG, consortium Ellipse/GAME-ON, consortium Practical, Henderson BE, Noushmehr H., Cozen W., Kote-Jarai Z., Eeles RA, Easton DF, Haiman CA, Lu W., Farnham PJ, and Coetzee GA PLoS genetics, 2014/01/01, Volume 10, Issue 1, p.e1004102, (2014) Read More / View Supplemental Materials
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Evidence that duplications of 22q11.2 protect against schizophrenia.Rees, E., Kirov G., Sanders A., Walters JT, Chambert KD, Shi J., Szatkiewicz J., O'Dushlaine C., Richards AL, Green EK, Jones I., Davies G., Legge SE, Moran JL, Pato C., Pato M., Genovese G., Levinson D., Duan J., Moy W., et al. Molecular psychiatry, 2014/01/01, Volume 19, Issue 1, p.37-40, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges.Diogo, D., Okada Y., and Plenge RM Current opinion in rheumatology, 2014/01/01, Volume 26, Issue 1, p.85-92, (2014) Read More / View Supplemental Materials
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High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons.Nieland, TJ, Logan DJ, Saulnier J., Lam D., Johnson C., Root DE, Carpenter AE, and Sabatini BL PloS one, 2014/01/01, Volume 9, Issue 3, p.e91744, (2014) Read More / View Supplemental Materials
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High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms.Kurki, MI, Gaál EI, Kettunen J., Lappalainen T., Menelaou A., Anttila V., van 't Hof FN, von Und Zu Fraunberg M., Helisalmi S., Hiltunen M., Lehto H., Laakso A., Kivisaari R., Koivisto T., Ronkainen A., Rinne J., Kiemeney LA, Vermeulen SH, Kaunisto MA, Eriksson JG, et al. PLoS genetics, 2014/01/01, Volume 10, Issue 1, p.e1004134, (2014) Read More / View Supplemental Materials
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An improved canine genome and a comprehensive catalogue of coding genes and non-coding transcripts.Hoeppner, MP, Lundquist A., Pirun M., Meadows JR, Zamani N., Johnson J., Sundström G., Cook A., FitzGerald MG, Swofford R., Mauceli E., Moghadam BT, Greka A., Alföldi J., Abouelleil A., Aftuck L., Bessette D., Berlin A., Brown A., Gearin G., et al. PloS one, 2014/01/01, Volume 9, Issue 3, p.e91172, (2014) Read More / View Supplemental Materials
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Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene.Okada, Y., Diogo D., Greenberg JD, Mouassess F., Achkar WA, Fulton RS, Denny JC, Gupta N., Mirel D., Gabriel S., Li G., Kremer JM, Pappas DA, Carroll RJ, Eyler AE, Trynka G., Stahl EA, Cui J., Saxena R., Coenen MJ, et al. PloS one, 2014/01/01, Volume 9, Issue 2, p.e87645, (2014) Read More / View Supplemental Materials
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Meta-Analysis Identifies Gene-by-Environment Interactions as Demonstrated in a Study of 4,965 Mice.Kang, EY, Han B., Furlotte N., Joo JW, Shih D., Davis RC, Lusis AJ, and Eskin E. PLoS genetics, 2014/01/01, Volume 10, Issue 1, p.e1004022, (2014) Read More / View Supplemental Materials
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MOSAIK: A Hash-Based Algorithm for Accurate Next-Generation Sequencing Short-Read Mapping.Lee, WP, Stromberg MP, Ward A., Stewart C., Garrison EP, and Marth GT PloS one, 2014/01/01, Volume 9, Issue 3, p.e90581, (2014) Read More / View Supplemental Materials
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A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in U2AF1 Reveals Commonly Altered Splicing Events.Brooks, AN, Choi PS, de Waal L., Sharifnia T., Imielinski M., Saksena G., Pedamallu CS, Sivachenko A., Rosenberg M., Chmielecki J., Lawrence MS, Deluca DS, Getz G., and Meyerson M. PloS one, 2014/01/01, Volume 9, Issue 1, p.e87361, (2014) Read More / View Supplemental Materials
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Pathway analyses implicate glial cells in schizophrenia.Duncan, LE, Holmans PA, Lee PH, O'Dushlaine CT, Kirby AW, Smoller JW, Öngür D., and Cohen BM PloS one, 2014/01/01, Volume 9, Issue 2, p.e89441, (2014) Read More / View Supplemental Materials
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Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci.Service, SK, Teslovich TM, Fuchsberger C., Ramensky V., Yajnik P., Koboldt DC, Larson DE, Zhang Q., Lin L., Welch R., Ding L., McLellan MD, O'Laughlin M., Fronick C., Fulton LL, Magrini V., Swift A., Elliott P., Jarvelin MR, Kaakinen M., et al. PLoS genetics, 2014/01/01, Volume 10, Issue 1, p.e1004147, (2014) Read More / View Supplemental Materials
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Revitalizing psychiatric therapeutics.Hyman, SE Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014/01/01, Volume 39, Issue 1, p.220-9, (2014) Read More / View Supplemental Materials
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RNA-Guided Genome Editing of Mammalian Cells.Pyzocha, NK, Ran FA, Hsu PD, and Zhang F. Methods in molecular biology (Clifton, N.J.), 2014/01/01, Volume 1114, p.269-77, (2014) Read More / View Supplemental Materials
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ZBED6 Modulates the Transcription of Myogenic Genes in Mouse Myoblast Cells.Jiang, L., Wallerman O., Younis S., Rubin CJ, Gilbert ER, Sundström E., Ghazal A., Zhang X., Wang L., Mikkelsen TS, Andersson G., and Andersson L. PloS one, 2014/01/01, Volume 9, Issue 4, p.e94187, (2014) Read More / View Supplemental Materials
Abstract
2013
S-Nitrosothiol Signaling Regulates Liver Development and Improves Outcome following Toxic Liver Injury.Cox, AG, Saunders DC, Kelsey PB Jr, Conway AA, Tesmenitsky Y., Marchini JF, Brown KK, Stamler JS, Colagiovanni DB, Rosenthal GJ, Croce KJ, North TE, and Goessling W. Cell reports, 2013/12/31, (2013) Read More / View Supplemental Materials
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Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association.Ostacher, MJ, Iosifescu DV, Hay A., Blumenthal SR, Sklar P., and Perlis RH Bipolar disorders, 2013/12/27, (2013) Read More / View Supplemental Materials
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Genetics of rheumatoid arthritis contributes to biology and drug discovery.Okada, Y., Wu D., Trynka G., Raj T., Terao C., Ikari K., Kochi Y., Ohmura K., Suzuki A., Yoshida S., Graham RR, Manoharan A., Ortmann W., Bhangale T., Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, et al. Nature, 2013/12/25, (2013) Read More / View Supplemental Materials
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Landscape of genomic alterations in cervical carcinomas.Ojesina, AI, Lichtenstein L., Freeman SS, Pedamallu CS, Imaz-Rosshandler I., Pugh TJ, Cherniack AD, Ambrogio L., Cibulskis K., Bertelsen B., Romero-Cordoba S., Treviño V., Vazquez-Santillan K., Guadarrama AS, Wright AA, Rosenberg MW, Duke F., Kaplan B., Wang R., Nickerson E., et al. Nature, 2013/12/25, (2013) Read More / View Supplemental Materials
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Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.The SIGMA Type 2 Diabetes, Consortium, team Writing, Williams AL, Jacobs SB, Moreno-Macías H., Huerta-Chagoya A., Churchhouse C., Márquez-Luna C., García-Ortíz H., José Gómez-Vázquez M., Burtt NP, Aguilar-Salinas CA, González-Villalpando C., Florez JC, Orozco L., Haiman CA, Tusié-Luna T., Altshuler D., team Analysis, Williams AL, et al. Nature, 2013/12/25, (2013) Read More / View Supplemental Materials
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Successful whole-exome sequencing from a prostate cancer bone metastasis biopsy.Van Allen, EM, Foye A., Wagle N., Kim W., Carter SL, McKenna A., Simko JP, Garraway LA, and Febbo PG Prostate cancer and prostatic diseases, 2013/12/24, (2013) Read More / View Supplemental Materials
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Bacterial toxins and small molecules elucidate endosomal trafficking.Slater, LH, Clatworthy AE, and Hung DT Trends in microbiology, 2013/12/23, (2013) Read More / View Supplemental Materials
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TRAF2 is an NF-κB-activating oncogene in epithelial cancers.Shen, RR, Zhou AY, Kim E., O'Connell JT, Hagerstrand D., Beroukhim R., and Hahn WC Oncogene, 2013/12/23, (2013) Read More / View Supplemental Materials
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Adult neural stem cells in distinct microdomains generate previously unknown interneuron types.Merkle, FT, Fuentealba LC, Sanders TA, Magno L., Kessaris N., and Alvarez-Buylla A. Nature neuroscience, 2013/12/22, (2013) Read More / View Supplemental Materials
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Genomic insights into WNT/β-catenin signaling.Rosenbluh, J., Wang X., and Hahn WC Trends in pharmacological sciences, 2013/12/20, (2013) Read More / View Supplemental Materials
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Aspirin Use, 8q24 Single Nucleotide Polymorphism rs6983267, and Colorectal Cancer According to CTNNB1 Alterations.Nan, H., Morikawa T., Suuriniemi M., Imamura Y., Werner L., Kuchiba A., Yamauchi M., Hunter DJ, Kraft P., Giovannucci EL, Fuchs CS, Ogino S., Freedman ML, and Chan AT Journal of the National Cancer Institute, 2013/12/18, Volume 105, Issue 24, p.1852-61, (2013) Read More / View Supplemental Materials
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Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo.Rouskin, S., Zubradt M., Washietl S., Kellis M., and Weissman JS Nature, 2013/12/15, (2013) Read More / View Supplemental Materials
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Meta-analysis of gene-level tests for rare variant association.Liu, DJ, Peloso GM, Zhan X., Holmen OL, Zawistowski M., Feng S., Nikpay M., Auer PL, Goel A., Zhang H., Peters U., Farrall M., Orho-Melander M., Kooperberg C., McPherson R., Watkins H., Willer CJ, Hveem K., Melander O., Kathiresan S., et al. Nature genetics, 2013/12/15, (2013) Read More / View Supplemental Materials
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Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair.Polak, P., Lawrence MS, Haugen E., Stoletzki N., Stojanov P., Thurman RE, Garraway LA, Mirkin S., Getz G., Stamatoyannopoulos JA, and Sunyaev SR Nature biotechnology, 2013/12/15, (2013) Read More / View Supplemental Materials
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Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing.Lin, PL, Ford CB, Coleman MT, Myers AJ, Gawande R., Ioerger T., Sacchettini J., Fortune SM, and Flynn JL Nature medicine, 2013/12/15, (2013) Read More / View Supplemental Materials
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EMRE is an essential component of the mitochondrial calcium uniporter complex.Sancak, Y., Markhard AL, Kitami T., Kovács-Bogdán E., Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D., Clapham DE, Li AA, Calvo SE, Goldberger O., and Mootha VK Science (New York, N.Y.), 2013/12/13, Volume 342, Issue 6164, p.1379-82, (2013) Read More / View Supplemental Materials
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Resource competition may lead to effective treatment of antibiotic resistant infections.Gomes, AL, Galagan JE, and Segrè D. PloS one, 2013/12/13, Volume 8, Issue 12, p.e80775, (2013) Read More / View Supplemental Materials
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Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments.Kheradpour, P., and Kellis M. Nucleic acids research, 2013/12/13, (2013) Read More / View Supplemental Materials
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Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.Karlsson, EK, Sigurdsson S., Ivansson E., Thomas R., Elvers I., Wright J., Howald C., Tonomura N., Perloski M., Swofford R., Biagi T., Fryc S., Anderson N., Courtay-Cahen C., Youell L., Ricketts SL, Mandlebaum S., Rivera P., von Euler H., Kisseberth WC, et al. Genome biology, 2013/12/12, Volume 14, Issue 12, p.R132, (2013) Read More / View Supplemental Materials
Abstract
High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development.Sharma, K., Choi SY, Zhang Y., Nieland TJ, Long S., Li M., and Huganir RL Cell reports, 2013/12/12, Volume 5, Issue 5, p.1330-41, (2013) Read More / View Supplemental Materials
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Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.Chapuy, B., McKeown MR, Lin CY, Monti S., Roemer MG, Qi J., Rahl PB, Sun HH, Yeda KT, Doench JG, Reichert E., Kung AL, Rodig SJ, Young RA, Shipp M. A., and Bradner JE Cancer cell, 2013/12/09, Volume 24, Issue 6, p.777-90, (2013) Read More / View Supplemental Materials
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Integrative and Comparative Genomic Analysis of Lung Squamous Cell Carcinomas in East Asian Patients.Kim, Y., Hammerman PS, Kim J., Yoon JA, Lee Y., Sun JM, Wilkerson MD, Pedamallu CS, Cibulskis K., Yoo YK, Lawrence MS, Stojanov P., Carter SL, McKenna A., Stewart C., Sivachenko AY, Oh IJ, Kim HK, Choi YS, Kim K., et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013/12/09, (2013) Read More / View Supplemental Materials
Abstract
SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer.Li, L., Shen C., Nakamura E., Ando K., Signoretti S., Beroukhim R., Cowley GS, Lizotte P., Liberzon E., Bair S., Root DE, Tamayo P., Tsherniak A., Cheng SC, Tabak B., Jacobsen A., Hakimi AA, Schultz N., Ciriello G., Sander C., et al. Cancer cell, 2013/12/09, Volume 24, Issue 6, p.738-50, (2013) Read More / View Supplemental Materials
Abstract
Statistical design for biospecimen cohort size in proteomics-based biomarker discovery and verification studies.Skates, SJ, Gillette MA, LaBaer J., Carr SA, Anderson L., Liebler DC, Ransohoff D., Rifai N., Kondratovich M., Težak Ž., Mansfield E., Oberg AL, Wright I., Barnes G., Gail M., Mesri M., Kinsinger CR, Rodriguez H., and Boja ES Journal of proteome research, 2013/12/06, Volume 12, Issue 12, p.5383-94, (2013) Read More / View Supplemental Materials
Abstract
Health disparities in kidney disease--emerging data from the human genome.Williams, WW, and Pollak MR The New England journal of medicine, 2013/12/05, Volume 369, Issue 23, p.2260-1, (2013) Read More / View Supplemental Materials
High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis.Schwartz, S., Agarwala SD, Mumbach MR, Jovanovic M., Mertins P., Shishkin A., Tabach Y., Mikkelsen TS, Satija R., Ruvkun G., Carr SA, Lander E. S., Fink GR, and Regev A. Cell, 2013/12/05, Volume 155, Issue 6, p.1409-21, (2013) Read More / View Supplemental Materials
Abstract
Multiplex cytological profiling assay to measure diverse cellular States.Gustafsdottir, SM, Ljosa V., Sokolnicki KL, Anthony Wilson J., Walpita D., Kemp MM, Petri Seiler K., Carrel HA, Golub T. R., Schreiber SL, Clemons PA, Carpenter AE, and Shamji AF PloS one, 2013/12/02, Volume 8, Issue 12, p.e80999, (2013) Read More / View Supplemental Materials
Abstract
Transcriptome complexity in germ cells .Soumillon, M. Medecine sciences : M/S, 2013/12/01, Volume 29, Issue 12, p.1077-9, (2013) Read More / View Supplemental Materials
Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements.Zhang, CZ, Leibowitz ML, and Pellman D. Genes & development, 2013/12/01, Volume 27, Issue 23, p.2513-30, (2013) Read More / View Supplemental Materials
Abstract
Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment.Ljosa, V., Caie PD, Ter Horst R., Sokolnicki KL, Jenkins EL, Daya S., Roberts ME, Jones TR, Singh S., Genovesio A., Clemons PA, Carragher NO, and Carpenter AE Journal of biomolecular screening, 2013/12/01, Volume 18, Issue 10, p.1321-9, (2013) Read More / View Supplemental Materials
Abstract
High-resolution microbial community reconstruction by integrating short reads from multiple 16S rRNA regions.Amir, A., Zeisel A., Zuk O., Elgart M., Stern S., Shamir O., Turnbaugh PJ, Soen Y., and Shental N. Nucleic acids research, 2013/12/01, Volume 41, Issue 22, p.e205, (2013) Read More / View Supplemental Materials
Abstract
Inferring developmental stage composition from gene expression in human malaria.Joice, R., Narasimhan V., Montgomery J., Sidhu AB, Oh K., Meyer E., Pierre-Louis W., Seydel K., Milner D., Williamson K., Wiegand R., Ndiaye D., Daily J., Wirth D., Taylor T., Huttenhower C., and Marti M. PLoS computational biology, 2013/12/01, Volume 9, Issue 12, p.e1003392, (2013) Read More / View Supplemental Materials
Abstract
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.Hartwell, KA, Miller PG, Mukherjee S., Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M., Järås M., Puram R., Dancik V., Al-Shahrour F., Kindler T., Tothova Z., Chattopadhyay S., Hasaka T., Narayan R., Dai M., Huang C., Shterental S., et al. Nature chemical biology, 2013/12/01, Volume 9, Issue 12, p.840-8, (2013) Read More / View Supplemental Materials
Abstract
Poly-combing the genome for RNA.Goff, LA, and Rinn JL Nature structural & molecular biology, 2013/12/01, Volume 20, Issue 12, p.1344-6, (2013) Read More / View Supplemental Materials
Quantifying Missing Heritability at Known GWAS Loci.Gusev, A., Bhatia G., Zaitlen N., Vilhjalmsson BJ, Diogo D., Stahl EA, Gregersen PK, Worthington J., Klareskog L., Raychaudhuri S., Plenge RM, Pasaniuc B., and Price AL PLoS genetics, 2013/12/01, Volume 9, Issue 12, p.e1003993, (2013) Read More / View Supplemental Materials
Abstract
Somatic mutation of CDKN1B in small intestine neuroendocrine tumors.Francis, JM, Kiezun A., Ramos AH, Serra S., Pedamallu CS, Qian ZR, Banck MS, Kanwar R., Kulkarni AA, Karpathakis A., Manzo V., Contractor T., Philips J., Nickerson E., Pho N., Hooshmand SM, Brais LK, Lawrence MS, Pugh T., McKenna A., et al. Nature genetics, 2013/12/01, Volume 45, Issue 12, p.1483-6, (2013) Read More / View Supplemental Materials
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The spirit of competition: to win or not to win.Szczepinska, T., Iwasaki W., and Abeel T. PLoS computational biology, 2013/12/01, Volume 9, Issue 12, p.e1003413, (2013) Read More / View Supplemental Materials
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Using chromatin marks to interpret and localize genetic associations to complex human traits and diseases.Trynka, G., and Raychaudhuri S. Current opinion in genetics & development, 2013/12/01, Volume 23, Issue 6, p.635-41, (2013) Read More / View Supplemental Materials
Abstract
Picking the lock on pluripotency.Eggan, K. The New England journal of medicine, 2013/11/28, Volume 369, Issue 22, p.2150-1, (2013) Read More / View Supplemental Materials
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.Ottoboni, L., Frohlich IY, Lee M., Healy BC, Keenan BT, Xia Z., Chitnis T., Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, and De Jager PL Neurology, 2013/11/26, Volume 81, Issue 22, p.1891-9, (2013) Read More / View Supplemental Materials
Abstract
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.Ruderfer, DM, Fanous AH, Ripke S., McQuillin A., Amdur RL, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Gejman PV, O'Donovan MC, Andreassen OA, Djurovic S., Hultman CM, Kelsoe JR, Jamain S., Landén M., Leboyer M., Nimgaonkar V., Nurnberger J., Smoller JW, et al. Molecular psychiatry, 2013/11/26, (2013) Read More / View Supplemental Materials
Abstract
A Small-Molecule Inducer of PDX1 Expression Identified by High-Throughput Screening.Yuan, Y., Hartland K., Boskovic Z., Wang Y., Walpita D., Lysy PA, Zhong C., Young DW, Kim YK, Tolliday NJ, Sokal EM, Schreiber SL, and Wagner BK Chemistry & biology, 2013/11/23, (2013) Read More / View Supplemental Materials
Abstract
Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease: A Genome-Wide Analysis of Common Variants.Dichgans, M., Malik R., König IR, Rosand J., Clarke R., Gretarsdottir S., Thorleifsson G., Mitchell BD, Assimes TL, Levi C., Odonnell CJ, Fornage M., Thorsteinsdottir U., Psaty BM, Hengstenberg C., Seshadri S., Erdmann J., Bis JC, Peters A., Boncoraglio GB, et al. Stroke; a journal of cerebral circulation, 2013/11/21, (2013) Read More / View Supplemental Materials
Abstract
DNA Sequencing of Cancer: What Have We Learned?Chmielecki, J., and Meyerson M. Annual review of medicine, 2013/11/20, (2013) Read More / View Supplemental Materials
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A Novel Deletion of IGF1 in a Patient With Idiopathic Short Stature Provides Insight Into IGF1 Haploinsufficiency.Batey, L., Moon JE, Yu Y., Wu B., Hirschhorn JN, Shen Y., and Dauber A. The Journal of clinical endocrinology and metabolism, 2013/11/15, (2013) Read More / View Supplemental Materials
Abstract
The plasticity of human Treg and Th17 cells and its role in autoimmunity.Kleinewietfeld, M., and Hafler DA Seminars in immunology, 2013/11/15, Volume 25, Issue 4, p.305-12, (2013) Read More / View Supplemental Materials
Abstract
Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32.Kawate, T., Iwase N., Shimizu M., Stanley SA, Wellington S., Kazyanskaya E., and Hung DT Bioorganic & medicinal chemistry letters, 2013/11/15, Volume 23, Issue 22, p.6052-9, (2013) Read More / View Supplemental Materials
Abstract
Modeling disease severity in multiple sclerosis using electronic health records.Xia, Z., Secor E., Chibnik LB, Bove RM, Cheng S., Chitnis T., Cagan A., Gainer VS, Chen PJ, Liao KP, Shaw SY, Ananthakrishnan AN, Szolovits P., Weiner HL, Karlson EW, Murphy SN, Savova GK, Cai T., Churchill SE, Plenge RM, et al. PloS one, 2013/11/11, Volume 8, Issue 11, p.e78927, (2013) Read More / View Supplemental Materials
Abstract
SCRIB and PUF60 Are Primary Drivers of the Multisystemic Phenotypes of the 8q24.3 Copy-Number Variant.Dauber, A., Golzio C., Guenot C., Jodelka FM, Kibaek M., Kjaergaard S., Leheup B., Martinet D., Nowaczyk MJ, Rosenfeld JA, Zeesman S., Zunich J., Beckmann JS, Hirschhorn JN, Hastings ML, Jacquemont S., and Katsanis N. American journal of human genetics, 2013/11/07, Volume 93, Issue 5, p.798-811, (2013) Read More / View Supplemental Materials
Abstract
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