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Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2015
Chromatin regulation at the frontier of synthetic biology.Keung, AJ, Joung JK, Khalil AS, and Collins JJ Nature reviews. Genetics, 2015/03/01, Volume 16, Issue 3, p.159-71, (2015) Read More / View Supplemental Materials
Abstract
Commentary: Insights from across diagnostic boundaries: ADHD in the RDoC era - a commentary on Scerif and Baker ().Doyle, AE Journal of child psychology and psychiatry, and allied disciplines, 2015/03/01, Volume 56, Issue 3, p.274-7, (2015) Read More / View Supplemental Materials
Abstract
Mosquito biology. Evolution of sexual traits influencing vectorial capacity in anopheline mosquitoes.Mitchell, SN, Kakani EG, South A., Howell PI, Waterhouse RM, and Catteruccia F. Science (New York, N.Y.), 2015/02/27, Volume 347, Issue 6225, p.985-8, (2015) Read More / View Supplemental Materials
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Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity.Majumder, B., Baraneedharan U., Thiyagarajan S., Radhakrishnan P., Narasimhan H., Dhandapani M., Brijwani N., Pinto DD, Prasath A., Shanthappa BU, Thayakumar A., Surendran R., Babu GK, Shenoy AM, Kuriakose MA, Bergthold G., Horowitz P., Loda M., Beroukhim R., Agarwal S., et al. Nature communications, 2015/02/27, Volume 6, p.6169, (2015) Read More / View Supplemental Materials
Abstract
Data sharing: Make outbreak research open access.Yozwiak, NL, Schaffner SF, and Sabeti PC Nature, 2015/02/26, Volume 518, Issue 7540, p.477-9, (2015) Read More / View Supplemental Materials
Draft Genome Sequence of the Cellulolytic Fungus Chaetomium globosum.Cuomo, CA, Untereiner WA, Ma LJ, Grabherr M., and Birren BW Genome announcements, 2015/02/26, Volume 3, Issue 1, (2015) Read More / View Supplemental Materials
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Glucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism.Raimondo, A., Rees MG, and Gloyn AL Current opinion in lipidology, 2015/02/24, (2015) Read More / View Supplemental Materials
Abstract
Searching for a minimal set of behaviors for autism detection through feature selection-based machine learning.Kosmicki, JA, Sochat V., Duda M., and Wall DP Translational psychiatry, 2015/02/24, Volume 5, p.e514, (2015) Read More / View Supplemental Materials
Abstract
Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors.Fall, T., Hägg S., Ploner A., Mägi R., Fischer K., Draisma HH, Sarin AP, Benyamin B., Ladenvall C., Åkerlund M., Kals M., Esko T., Nelson CP, Kaakinen M., Huikari V., Mangino M., Meirhaeghe A., Kristiansson K., Nuotio ML, Kobl M., et al. Diabetes, 2015/02/23, (2015) Read More / View Supplemental Materials
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Oncotator: Cancer Variant Annotation Tool.Ramos, AH, Lichtenstein L., Gupta M., Lawrence MS, Pugh TJ, Saksena G., Meyerson M., and Getz G. Human mutation, 2015/02/23, (2015) Read More / View Supplemental Materials
Abstract
BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair.Hatchi, E., Skourti-Stathaki K., Ventz S., Pinello L., Yen A., Kamieniarz-Gdula K., Dimitrov S., Pathania S., McKinney KM, Eaton ML, Kellis M., Hill SJ, Parmigiani G., Proudfoot NJ, and Livingston DM Molecular cell, 2015/02/19, Volume 57, Issue 4, p.636-47, (2015) Read More / View Supplemental Materials
Abstract
Cell-of-origin chromatin organization shapes the mutational landscape of cancer.Polak, P., Karlić R., Koren A., Thurman R., Sandstrom R., Lawrence MS, Reynolds A., Rynes E., Vlahoviček K., Stamatoyannopoulos JA, and Sunyaev SR Nature, 2015/02/19, Volume 518, Issue 7539, p.360-4, (2015) Read More / View Supplemental Materials
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Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease.Gjoneska, E., Pfenning AR, Mathys H., Quon G., Kundaje A., Tsai LH, and Kellis M. Nature, 2015/02/19, Volume 518, Issue 7539, p.365-9, (2015) Read More / View Supplemental Materials
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Integrative analysis of 111 reference human epigenomes.Roadmap Epigenomics, Consortium, Kundaje A., Meuleman W., Ernst J., Bilenky M., Yen A., Heravi-Moussavi A., Kheradpour P., Zhang Z., Wang J., Ziller MJ, Amin V., Whitaker JW, Schultz MD, Ward LD, Sarkar A., Quon G., Sandstrom RS, Eaton ML, Wu YC, et al. Nature, 2015/02/19, Volume 518, Issue 7539, p.317-30, (2015) Read More / View Supplemental Materials
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Transcription factor binding dynamics during human ES cell differentiation.Tsankov, AM, Gu H., Akopian V., Ziller MJ, Donaghey J., Amit I., Gnirke A., and Meissner A. Nature, 2015/02/19, Volume 518, Issue 7539, p.344-9, (2015) Read More / View Supplemental Materials
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Intermediate DNA methylation is a conserved signature of genome regulation.Elliott, G., Hong C., Xing X., Zhou X., Li D., Coarfa C., Bell RJ, Maire CL, Ligon KL, Sigaroudinia M., Gascard P., Tlsty TD, Harris RA, Schalkwyk LC, Bilenky M., Mill J., Farnham PJ, Kellis M., Marra MA, Milosavljevic A., et al. Nature communications, 2015/02/18, Volume 6, p.6363, (2015) Read More / View Supplemental Materials
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Large-scale imputation of epigenomic datasets for systematic annotation of diverse human tissues.Ernst, J., and Kellis M. Nature biotechnology, 2015/02/18, (2015) Read More / View Supplemental Materials
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Cutting the Gordian Helix - Regulating Genomic Testing in the Era of Precision Medicine.Lander, E. S. The New England journal of medicine, 2015/02/17, (2015) Read More / View Supplemental Materials
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Generation and Characterization of Rat iPSCs.Liao, J., and Cui C. Methods in molecular biology (Clifton, N.J.), 2015/02/17, (2015) Read More / View Supplemental Materials
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Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.Merkle, FT, Maroof A., Wataya T., Sasai Y., Studer L., Eggan K., and Schier AF Development (Cambridge, England), 2015/02/15, Volume 142, Issue 4, p.633-43, (2015) Read More / View Supplemental Materials
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Drug discovery. Tying up a transcription factor.Chen, A., and Koehler AN Science (New York, N.Y.), 2015/02/13, Volume 347, Issue 6223, p.713-4, (2015) Read More / View Supplemental Materials
Expanding the phenotype of GMPPB mutations.Cabrera-Serrano, M., Ghaoui R., Ravenscroft G., Johnsen RD, Davis MR, Corbett A., Reddel S., Sue CM, Liang C., Waddell LB, Kaur S., Lek M., North KN, Macarthur DG, Lamont PJ, Clarke NF, and Laing NG Brain : a journal of neurology, 2015/02/12, (2015) Read More / View Supplemental Materials
Abstract
Genetic studies of body mass index yield new insights for obesity biology.Locke, AE, Kahali B., Berndt SI, Justice AE, Pers TH, Day FR, Powell C., Vedantam S., Buchkovich ML, Yang J., Croteau-Chonka DC, Esko T., Fall T., Ferreira T., Gustafsson S., Kutalik Z., Luan J., Mägi R., Randall JC, Winkler TW, et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.197-206, (2015) Read More / View Supplemental Materials
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New genetic loci link adipose and insulin biology to body fat distribution.Shungin, D., Winkler TW, Croteau-Chonka DC, Ferreira T., Locke AE, Mägi R., Strawbridge RJ, Pers TH, Fischer K., Justice AE, Workalemahu T., Wu JM, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C., Gustafsson S., Day FR, Esko T., et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.187-96, (2015) Read More / View Supplemental Materials
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Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits.Zhu, Z., Bakshi A., Vinkhuyzen AA, Hemani G., Lee SH, Nolte IM, van Vliet-Ostaptchouk JV, Snieder H., The LifeLines Cohort Study, Esko T., Milani L., Mägi R., Metspalu A., Hill WG, Weir BS, Goddard ME, Visscher PM, and Yang J. American journal of human genetics, 2015/02/11, (2015) Read More / View Supplemental Materials
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The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes.Kostic, AD, Gevers D., Siljander H., Vatanen T., Hyötyläinen T., Hämäläinen AM, Peet A., Tillmann V., Pöhö P., Mattila I., Lähdesmäki H., Franzosa EA, Vaarala O., de Goffau M., Harmsen H., Ilonen J., Virtanen SM, Clish CB, Orešič M., Huttenhower C., et al. Cell host & microbe, 2015/02/11, Volume 17, Issue 2, p.260-73, (2015) Read More / View Supplemental Materials
Abstract
Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment.Rudenko, A., Seo J., Hu J., Su SC, de Anda FC, Durak O., Ericsson M., Carlén M., and Tsai LH The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015/02/11, Volume 35, Issue 6, p.2372-83, (2015) Read More / View Supplemental Materials
Abstract
Massively expedited genome-wide heritability analysis (MEGHA).Ge, T., Nichols TE, Lee PH, Holmes AJ, Roffman JL, Buckner RL, Sabuncu MR, and Smoller JW Proceedings of the National Academy of Sciences of the United States of America, 2015/02/09, (2015) Read More / View Supplemental Materials
Abstract
Anterior commissural white matter fiber abnormalities in first-episode psychosis: A tractography study.Kikinis, Z., Fitzsimmons J., Dunn C., Vu MA, Makris N., Bouix S., Goldstein JM, Mesholam-Gately RI, Petryshen T., Del Re EC, Wojcik J., Seidman LJ, and Kubicki M. Schizophrenia research, 2015/02/06, (2015) Read More / View Supplemental Materials
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Therapeutic genome editing: prospects and challenges.Cox, DB, Platt RJ, and Zhang F. Nature medicine, 2015/02/05, Volume 21, Issue 2, p.121-131, (2015) Read More / View Supplemental Materials
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16S Community Profiling Identifies Proton Pump Inhibitor Related Differences in Gastric, Lung, and Oropharyngeal Microflora.Rosen, R., Hu L., Amirault J., Khatwa U., Ward DV, and Onderdonk A. The Journal of pediatrics, 2015/02/04, (2015) Read More / View Supplemental Materials
Abstract
Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro.Ng, S., Schwartz RE, March S., Galstian A., Gural N., Shan J., Prabhu M., Mota MM, and Bhatia SN Stem cell reports, 2015/02/04, (2015) Read More / View Supplemental Materials
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A Massive Expansion of Effector Genes Underlies Gall-Formation in the Wheat Pest Mayetiola destructor.Zhao, C., Escalante LN, Chen H., Benatti TR, Qu J., Chellapilla S., Waterhouse RM, Wheeler D., Andersson MN, Bao R., Batterton M., Behura SK, Blankenburg KP, Caragea D., Carolan JC, Coyle M., El-Bouhssini M., Francisco L., Friedrich M., Gill N., et al. Current biology : CB, 2015/02/04, (2015) Read More / View Supplemental Materials
Abstract
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.Chattopadhyay, S., Stewart AL, Mukherjee S., Huang C., Hartwell KA, Miller PG, Subramanian R., Carmody LC, Yusuf RZ, Sykes DB, Paulk J., Vetere A., Vallet S., Santo L., Cirstea DD, Hideshima T., Dančík V., Majireck MM, Hussain MM, Singh S., et al. Cell reports, 2015/02/04, (2015) Read More / View Supplemental Materials
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PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.Nath, AK, Ryu JH, Jin YN, Roberts LD, Dejam A., Gerszten RE, and Peterson RT Cell reports, 2015/02/04, (2015) Read More / View Supplemental Materials
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The TMEM106B locus and TDP-43 pathology in older persons without FTLD.Yu, L., De Jager PL, Yang J., Trojanowski JQ, Bennett DA, and Schneider JA Neurology, 2015/02/04, (2015) Read More / View Supplemental Materials
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Boosting bacterial metabolism to combat antibiotic resistance.Bhargava, P., and Collins JJ Cell metabolism, 2015/02/03, Volume 21, Issue 2, p.154-5, (2015) Read More / View Supplemental Materials
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Enabling Consistency in Pluripotent Stem Cell-Derived Products for Research and Development and Clinical Applications Through Material Standards.French, A., Bravery C., Smith J., Chandra A., Archibald P., Gold JD, Artzi N., Kim HW, Barker RW, Meissner A., Wu JC, Knowles JC, Williams D., García-Cardeña G., Sipp D., Oh S., Loring JF, Rao MS, Reeve B., Wall I., et al. Stem cells translational medicine, 2015/02/03, (2015) Read More / View Supplemental Materials
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The evolution of drug resistance in clinical isolates of Candida albicans.Ford, CB, Funt JM, Abbey D., Issi L., Guiducci C., Martinez DA, Delorey T., Li BY, White TC, Cuomo C., Rao RP, Berman J., Thompson DA, and Regev A. eLife, 2015/02/03, Volume 4, (2015) Read More / View Supplemental Materials
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Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949).Davies, G., Armstrong N., Bis JC, Bressler J., Chouraki V., Giddaluru S., Hofer E., Ibrahim-Verbaas CA, Kirin M., Lahti J., van der Lee SJ, Le Hellard S., Liu T., Marioni RE, Oldmeadow C., Postmus I., Smith AV, Smith JA, Thalamuthu A., Thomson R., et al. Molecular psychiatry, 2015/02/03, (2015) Read More / View Supplemental Materials
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Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.Im, HK, Zheng S., Amini SS, Virk SM, Mikkelsen T., Brat DJ, Grimsby J., Sougnez C., Muller F., Hu J., Sloan AE, Cohen ML, Van Meir EG, Scarpace L., Laird PW, Weinstein J. N., Lander E. S., Gabriel S., Getz G., Meyerson M., et al. Genome research, 2015/02/03, (2015) Read More / View Supplemental Materials
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Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.Liu, H., Irwanto A., Fu X., Yu G., Yu Y., Sun Y., Wang C., Wang Z., Okada Y., Low H., Li Y., Liany H., Chen M., Bao F., Li J., You J., Zhang Q., Liu J., Chu T., Andiappan AK, et al. Nature genetics, 2015/02/02, (2015) Read More / View Supplemental Materials
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Efficient Bayesian mixed-model analysis increases association power in large cohorts.Loh, PR, Tucker G., Bulik-Sullivan BK, Vilhjálmsson BJ, Finucane HK, Salem RM, Chasman DI, Ridker PM, Neale BM, Berger B., Patterson N., and Price AL Nature genetics, 2015/02/02, (2015) Read More / View Supplemental Materials
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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.Bulik-Sullivan, BK, Loh PR, Finucane HK, Ripke S., Yang J., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson N., Daly M. J., Price AL, and Neale BM Nature genetics, 2015/02/02, (2015) Read More / View Supplemental Materials
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Message from the ISCB: ISCB Ebola award for important future research on the computational biology of Ebola virus.Karp, PD, Berger B., Kovats D., Lengauer T., Linial M., Sabeti P., Hide W., and Rost B. Bioinformatics (Oxford, England), 2015/02/02, (2015) Read More / View Supplemental Materials
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A split-Cas9 architecture for inducible genome editing and transcription modulation.Zetsche, B., Volz SE, and Zhang F. Nature biotechnology, 2015/02/02, Volume 33, Issue 2, p.139-142, (2015) Read More / View Supplemental Materials
Therapeutic Insights from Genomic Studies of Head and Neck Squamous Cell Carcinomas.Hammerman, PS, Hayes DN, and Grandis JR Cancer discovery, 2015/02/02, (2015) Read More / View Supplemental Materials
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Common and Rare Variants in SCN10A Modulate the Risk of Atrial Fibrillation.Jabbari, J., Olesen MS, Yuan L., Nielsen JB, Liang B., Macri V., Christophersen IE, Nielsen N., Sajadieh A., Ellinor PT, Grunnet M., Haunsø S., Holst AG, Svendsen JH, and Jespersen T. Circulation. Cardiovascular genetics, 2015/02/01, Volume 8, Issue 1, p.64-73, (2015) Read More / View Supplemental Materials
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Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons.Yoshimizu, T., Pan JQ, Mungenast AE, Madison JM, Su S., Ketterman J., Ongur D., McPhie D., Cohen B., Perlis R., and Tsai LH Molecular psychiatry, 2015/02/01, Volume 20, Issue 2, p.162-9, (2015) Read More / View Supplemental Materials
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Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers.Tonomura, N., Elvers I., Thomas R., Megquier K., Turner-Maier J., Howald C., Sarver AL, Swofford R., Frantz AM, Ito D., Mauceli E., Arendt M., Noh HJ, Koltookian M., Biagi T., Fryc S., Williams C., Avery AC, Kim JH, Barber L., et al. PLoS genetics, 2015/02/01, Volume 11, Issue 2, p.e1004922, (2015) Read More / View Supplemental Materials
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Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas.Mroz, EA, Tward AM, Hammon RJ, Ren Y., and Rocco JW PLoS medicine, 2015/02/01, Volume 12, Issue 2, p.e1001786, (2015) Read More / View Supplemental Materials
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Somatic mutations and atrial fibrillation: the end or just the beginning?Lubitz, SA, and Ellinor PT Circulation. Cardiovascular genetics, 2015/02/01, Volume 8, Issue 1, p.2-3, (2015) Read More / View Supplemental Materials
Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction.Thormaehlen, AS, Schuberth C., Won HH, Blattmann P., Joggerst-Thomalla B., Theiss S., Asselta R., Duga S., Merlini PA, Ardissino D., Lander E. S., Gabriel S., Rader DJ, Peloso GM, Pepperkok R., Kathiresan S., and Runz H. PLoS genetics, 2015/02/01, Volume 11, Issue 2, p.e1004855, (2015) Read More / View Supplemental Materials
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Top advances in functional genomics and translational biology for 2014.Gupta, RM, Pilbrow AP, and Weeke PE Circulation. Cardiovascular genetics, 2015/02/01, Volume 8, Issue 1, p.207-10, (2015) Read More / View Supplemental Materials
Disease-specific alterations in the enteric virome in inflammatory bowel disease.Norman, JM, Handley SA, Baldridge MT, Droit L., Liu CY, Keller BC, Kambal A., Monaco CL, Zhao G., Fleshner P., Stappenbeck TS, McGovern DP, Keshavarzian A., Mutlu EA, Sauk J., Gevers D., Xavier RJ, Wang D., Parkes M., and Virgin HW Cell, 2015/01/29, Volume 160, Issue 3, p.447-60, (2015) Read More / View Supplemental Materials
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Famine versus feast: understanding the metabolism of tumors in vivo.Mayers, JR, and Vander Heiden MG Trends in biochemical sciences, 2015/01/29, (2015) Read More / View Supplemental Materials
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Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.Wessel, J., Chu AY, Willems SM, Wang S., Yaghootkar H., Brody JA, Dauriz M., Hivert MF, Raghavan S., Lipovich L., Hidalgo B., Fox K., Huffman JE, An P., Lu Y., Rasmussen-Torvik LJ, Grarup N., Ehm MG, Li L., Baldridge AS, et al. Nature communications, 2015/01/29, Volume 6, p.5897, (2015) Read More / View Supplemental Materials
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Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.Bavamian, S., Mellios N., Lalonde J., Fass DM, Wang J., Sheridan SD, Madison JM, Zhou F., Rueckert EH, Barker D., Perlis RH, Sur M., and Haggarty SJ Molecular psychiatry, 2015/01/27, (2015) Read More / View Supplemental Materials
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Exome Sequencing in Suspected Monogenic Dyslipidemias.Stitziel, NO, Peloso GM, Abifadel M., Cefalù AB, Fouchier S., Motazacker MM, Tada H., Larach DB, Awan Z., Haller JF, Pullinger CR, Varret M., Rabès JP, Noto D., Tarugi P., Kawashiri MA, Nohara A., Yamagishi M., Risman M., Deo R., et al. Circulation. Cardiovascular genetics, 2015/01/27, (2015) Read More / View Supplemental Materials
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Convergent evolution of the genomes of marine mammals.Foote, AD, Liu Y., Thomas GW, Vinař T., Alföldi J., Deng J., Dugan S., van Elk CE, Hunter ME, Joshi V., Khan Z., Kovar C., Lee SL, Lindblad-Toh K., Mancia A., Nielsen R., Qin X., Qu J., Raney BJ, Vijay N., et al. Nature genetics, 2015/01/26, (2015) Read More / View Supplemental Materials
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Large multiallelic copy number variations in humans.Handsaker, RE, Van Doren V., Berman JR, Genovese G., Kashin S., Boettger LM, and McCarroll SA Nature genetics, 2015/01/26, (2015) Read More / View Supplemental Materials
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Next Generation Sequencing for the Diagnosis of Cardiac Arrhythmia Syndromes.Lubitz, SA, and Ellinor PT Heart rhythm : the official journal of the Heart Rhythm Society, 2015/01/24, (2015) Read More / View Supplemental Materials
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Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis.Ludwig, LS, Cho H., Wakabayashi A., Eng JC, Ulirsch JC, Fleming MD, Lodish HF, and Sankaran VG American journal of hematology, 2015/01/23, (2015) Read More / View Supplemental Materials
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Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke.Holliday, EG, Traylor M., Malik R., Bevan S., Falcone G., Hopewell JC, Cheng YC, Cotlarciuc I., Bis JC, Boerwinkle E., Boncoraglio GB, Clarke R., Cole JW, Fornage M., Furie KL, Ikram MA, Jannes J., Kittner SJ, Lincz LF, Maguire JM, et al. Stroke; a journal of cerebral circulation, 2015/01/22, (2015) Read More / View Supplemental Materials
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Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.Betz, RC, Petukhova L., Ripke S., Huang H., Menelaou A., Redler S., Becker T., Heilmann S., Yamany T., Duvic M., Hordinsky M., Norris D., Price VH, Mackay-Wiggan J., de Jong A., DeStefano GM, Moebus S., Böhm M., Blume-Peytavi U., Wolff H., et al. Nature communications, 2015/01/22, Volume 6, p.5966, (2015) Read More / View Supplemental Materials
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Quantitative visualization of alternative exon expression from RNA-seq data.Katz, Y., Wang ET, Silterra J., Schwartz S., Wong B., Thorvaldsdóttir H., Robinson JT, Mesirov J. P., Airoldi EM, and Burge CB Bioinformatics (Oxford, England), 2015/01/22, (2015) Read More / View Supplemental Materials
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Age- and Pregnancy-Associated DNA Methylation Changes in Mammary Epithelial Cells.Huh, SJ, Clement K., Jee D., Merlini A., Choudhury S., Maruyama R., Yoo R., Chytil A., Boyle P., Ran FA, Moses HL, Barcellos-Hoff MH, Jackson-Grusby L., Meissner A., and Polyak K. Stem cell reports, 2015/01/21, (2015) Read More / View Supplemental Materials
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Risk profiles for aortic dissection and ruptured or surgically treated aneurysms: a prospective cohort study.Landenhed, M., Engström G., Gottsäter A., Caulfield MP, Hedblad B., Newton-Cheh C., Melander O., and Smith JG Journal of the American Heart Association, 2015/01/21, Volume 4, Issue 1, (2015) Read More / View Supplemental Materials
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Purinosome formation as a function of the cell cycle.Chan, CY, Zhao H., Pugh RJ, Pedley AM, French J., Jones SA, Zhuang X., Jinnah H., Huang TJ, and Benkovic SJ Proceedings of the National Academy of Sciences of the United States of America, 2015/01/20, (2015) Read More / View Supplemental Materials
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Biological interpretation of genome-wide association studies using predicted gene functions.Pers, TH, Karjalainen JM, Chan Y., Westra HJ, Wood AR, Yang J., Lui JC, Vedantam S., Gustafsson S., Esko T., Frayling T., Speliotes EK, Genetic Investigation of ANthropometric Traits(GIANT) Consortium, Boehnke M., Raychaudhuri S., Fehrmann RS, Hirschhorn JN, and Franke L. Nature communications, 2015/01/19, Volume 6, p.5890, (2015) Read More / View Supplemental Materials
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mTOR pathway mutations cause hemimegalencephaly and focal cortical dysplasia.D'Gama, AM, Geng Y., Couto JA, Martin B., Boyle EA, LaCoursiere CM, Hossain A., Hatem NE, Barry B., Kwiatkowski DJ, Vinters HV, Barkovich AJ, Shendure J., Mathern GW, Walsh CA, and Poduri A. Annals of neurology, 2015/01/19, (2015) Read More / View Supplemental Materials
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Partial uracil-DNA-glycosylase treatment for screening of ancient DNA.Rohland, N., Harney E., Mallick S., Nordenfelt S., and Reich D. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015/01/19, Volume 370, Issue 1660, (2015) Read More / View Supplemental Materials
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A kernel machine method for detecting effects of interaction between multidimensional variable sets: An imaging genetics application.Ge, T., Nichols TE, Ghosh D., Mormino EC, Smoller JW, Sabuncu MR, and for the Alzheimer's Disease Neuroimaging Initiative NeuroImage, 2015/01/16, (2015) Read More / View Supplemental Materials
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(Epi)Genomics approaches and their applications.Meissner, A. Methods (San Diego, Calif.), 2015/01/15, Volume 72, p.1-2, (2015) Read More / View Supplemental Materials
CDy6, a Photostable Probe for Long-Term Real-Time Visualization of Mitosis and Proliferating Cells.Jeong, YM, Duanting Z., Hennig H., Samanta A., Agrawalla BK, Bray MA, Carpenter AE, and Chang YT Chemistry & biology, 2015/01/15, (2015) Read More / View Supplemental Materials
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Molecular and genetic properties of tumors associated with local immune cytolytic activity.Rooney, MS, Shukla SA, Wu CJ, Getz G., and Hacohen N. Cell, 2015/01/15, Volume 160, Issue 1-2, p.48-61, (2015) Read More / View Supplemental Materials
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Nutrient-sensing mechanisms and pathways.Efeyan, A., Comb WC, and Sabatini DM Nature, 2015/01/15, Volume 517, Issue 7534, p.302-10, (2015) Read More / View Supplemental Materials
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Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.Roberts, AM, Ware JS, Herman DS, Schafer S., Baksi J., Bick AG, Buchan RJ, Walsh R., John S., Wilkinson S., Mazzarotto F., Felkin LE, Gong S., L MacArthur JA, Cunningham F., Flannick J., Gabriel SB, Altshuler DM, Macdonald PS, Heinig M., et al. Science translational medicine, 2015/01/14, Volume 7, Issue 270, p.270ra6, (2015) Read More / View Supplemental Materials
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The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells.Wang, H., Yu C., Gao X., Welte T., Muscarella AM, Tian L., Zhao H., Zhao Z., Du S., Tao J., Lee B., Westbrook TF, Wong ST, Jin X., Rosen JM, Osborne CK, and Zhang XH Cancer cell, 2015/01/14, (2015) Read More / View Supplemental Materials
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The DNA-binding network of Mycobacterium tuberculosis.Minch, KJ, Rustad TR, Peterson EJ, Winkler J., Reiss DJ, Ma S., Hickey M., Brabant W., Morrison B., Turkarslan S., Mawhinney C., Galagan JE, Price ND, Baliga NS, and Sherman DR Nature communications, 2015/01/12, Volume 6, p.5829, (2015) Read More / View Supplemental Materials
Abstract
Gene expression analysis identifies global gene dosage sensitivity in cancer.Fehrmann, RS, Karjalainen JM, Krajewska M., Westra HJ, Maloney D., Simeonov A., Pers TH, Hirschhorn JN, Jansen RC, Schultes EA, van Haagen HH, de Vries EG, Te Meerman GJ, Wijmenga C., van Vugt MA, and Franke L. Nature genetics, 2015/01/12, (2015) Read More / View Supplemental Materials
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A Mechanism for Asymmetric Cell Division Resulting in Proliferative Asynchronicity.Dey-Guha, I., Alves CP, Yeh AC, Salony, Sole X., Darp R., and Ramaswamy S. Molecular cancer research : MCR, 2015/01/12, (2015) Read More / View Supplemental Materials
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No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans.Do, R., Balick D., Li H., Adzhubei I., Sunyaev S., and Reich D. Nature genetics, 2015/01/12, (2015) Read More / View Supplemental Materials
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Pluripotency transcription factor Oct4 mediates stepwise nucleosome demethylation and depletion.Shakya, A., Callister C., Goren A., Yosef N., Garg N., Khoddami V., Nix D., Regev A., and Tantin D. Molecular and cellular biology, 2015/01/12, (2015) Read More / View Supplemental Materials
Abstract
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.Wang, S., Tsun ZY, Wolfson RL, Shen K., Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L., Comb W., Wang T., Bar-Peled L., Zoncu R., Straub C., Kim C., Park J., Sabatini BL, and Sabatini DM Science (New York, N.Y.), 2015/01/09, Volume 347, Issue 6218, p.188-94, (2015) Read More / View Supplemental Materials
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Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation.Biagioli, M., Ferrari F., Mendenhall EM, Zhang Y., Erdin S., Vijayvargia R., Vallabh SM, Solomos N., Manavalan P., Ragavendran A., Ozsolak F., Lee JM, Talkowski ME, Gusella JF, Macdonald ME, Park PJ, and Seong IS Human molecular genetics, 2015/01/08, (2015) Read More / View Supplemental Materials
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Metabolite Profiling and Cardiovascular Event Risk: A Prospective Study of Three Population-Based Cohorts.Würtz, P., Havulinna AS, Soininen P., Tynkkynen T., Prieto-Merino D., Tillin T., Ghorbani A., Artati A., Wang Q., Tiainen M., Kangas AJ, Kettunen J., Kaikkonen J., Mikkilä V., Jula A., Kähönen M., Lehtimäki T., Lawlor DA, Gaunt TR, Hughes AD, et al. Circulation, 2015/01/08, (2015) Read More / View Supplemental Materials
Abstract
Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides.Scully, SS, Zheng SL, Wagner BK, and Schreiber SL Organic letters, 2015/01/08, (2015) Read More / View Supplemental Materials
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Using cross-classified multilevel models to disentangle school and neighborhood effects: An example focusing on smoking behaviors among adolescents in the United States.Dunn, EC, Richmond TK, Milliren CE, and Subramanian SV Health & place, 2015/01/08, Volume 31C, p.224-232, (2015) Read More / View Supplemental Materials
Abstract
Cell lineage analysis in human brain using endogenous retroelements.Evrony, GD, Lee E., Mehta BK, Benjamini Y., Johnson RM, Cai X., Yang L., Haseley P., Lehmann HS, Park PJ, and Walsh CA Neuron, 2015/01/07, Volume 85, Issue 1, p.49-59, (2015) Read More / View Supplemental Materials
Abstract
Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions.Xu, J., Shao Z., Li D., Xie H., Kim W., Huang J., Taylor JE, Pinello L., Glass K., Jaffe JD, Yuan GC, and Orkin SH Molecular cell, 2015/01/07, (2015) Read More / View Supplemental Materials
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Discovery and annotation of long noncoding RNAs.Mattick, JS, and Rinn JL Nature structural & molecular biology, 2015/01/07, Volume 22, Issue 1, p.5-7, (2015) Read More / View Supplemental Materials
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Copy number variation in bipolar disorder.Green, EK, Rees E., Walters JT, Smith KG, Forty L., Grozeva D., Moran JL, Sklar P., Ripke S., Chambert KD, Genovese G., McCarroll SA, Jones I., Jones L., Owen MJ, O'Donovan MC, Craddock N., and Kirov G. Molecular psychiatry, 2015/01/06, (2015) Read More / View Supplemental Materials
Abstract
High-throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic Beta-cell function.Burns, SM, Vetere A., Walpita D., Dančík V., Khodier C., Perez J., Clemons PA, Wagner BK, and Altshuler D. Cell metabolism, 2015/01/06, Volume 21, Issue 1, p.126-37, (2015) Read More / View Supplemental Materials
Abstract
An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma.Baratta, MG, Schinzel AC, Zwang Y., Bandopadhayay P., Bowman-Colin C., Kutt J., Curtis J., Piao H., Wong LC, Kung AL, Beroukhim R., Bradner JE, Drapkin R., Hahn WC, Liu JF, and Livingston DM Proceedings of the National Academy of Sciences of the United States of America, 2015/01/06, Volume 112, Issue 1, p.232-7, (2015) Read More / View Supplemental Materials
Abstract
Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.Palsson-McDermott, EM, Curtis AM, Goel G., Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R., Johnson DG, Jiang JK, Israelsen WJ, Keane J., Thomas C., Clish C., Vanden Heiden M., Xavier RJ, and O'Neill LA Cell metabolism, 2015/01/06, Volume 21, Issue 1, p.65-80, (2015) Read More / View Supplemental Materials
Abstract
Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington's disease.Shema, R., Kulicke R., Cowley GS, Stein R., Root DE, and Heiman M. Proceedings of the National Academy of Sciences of the United States of America, 2015/01/06, Volume 112, Issue 1, p.268-72, (2015) Read More / View Supplemental Materials
Abstract
Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera.Ellis, CN, LaRocque RC, Uddin T., Krastins B., Mayo-Smith L., Sarracino D., Karlsson E., Rahman A., Shirin T., Bhuiyan TR, Chowdhury F., Kahn AI, Ryan ET, Calderwood SB, Qadri F., and Harris JB Infection and immunity, 2015/01/05, (2015) Read More / View Supplemental Materials
Abstract
Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion.Shen, H., Cavallero S., Estrada KD, Sandovici I., Kumar SR, Makita T., Lien CL, Constancia M., and Sucov HM Cardiovascular research, 2015/01/05, (2015) Read More / View Supplemental Materials
Abstract
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