<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hieronymus,Haley</style></author><author><style face="normal" font="default" size="100%">Lamb,Justin</style></author><author><style face="normal" font="default" size="100%">Ross,Kenneth N</style></author><author><style face="normal" font="default" size="100%">Peng,Xiao P</style></author><author><style face="normal" font="default" size="100%">Clement,Cristina</style></author><author><style face="normal" font="default" size="100%">Rodina,Anna</style></author><author><style face="normal" font="default" size="100%">Nieto,Maria</style></author><author><style face="normal" font="default" size="100%">Du,Jinyan</style></author><author><style face="normal" font="default" size="100%">Stegmaier,Kimberly</style></author><author><style face="normal" font="default" size="100%">Raj,Srilakshmi M</style></author><author><style face="normal" font="default" size="100%">Maloney,Katherine N</style></author><author><style face="normal" font="default" size="100%">Clardy,Jon</style></author><author><style face="normal" font="default" size="100%">Hahn,William C</style></author><author><style face="normal" font="default" size="100%">Chiosis,Gabriela</style></author><author><style face="normal" font="default" size="100%">Golub,Todd R</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators</style></title><secondary-title><style face="normal" font="default" size="100%">Cancer Cell</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibiotics</style></keyword><keyword><style  face="normal" font="default" size="100%">Antineoplastic</style></keyword><keyword><style  face="normal" font="default" size="100%">bcr-abl</style></keyword><keyword><style  face="normal" font="default" size="100%">Benzoquinones</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Culture Techniques</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Survival</style></keyword><keyword><style  face="normal" font="default" size="100%">fms-Like Tyrosine Kinase 3</style></keyword><keyword><style  face="normal" font="default" size="100%">Fusion Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Profiling</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome</style></keyword><keyword><style  face="normal" font="default" size="100%">HSP90 Heat-Shock Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Hu</style></keyword><keyword><style  face="normal" font="default" size="100%">Human</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006/10//</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/17010675</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">321 - 30</style></pages><isbn><style face="normal" font="default" size="100%">1535-6108</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Although androgen receptor (AR)-mediated signaling is central to prostate cancer, the ability to modulate AR signaling states is limited. Here we establish a chemical genomic approach for discovery and target prediction of modulators of cancer phenotypes, as exemplified by AR signaling. We first identify AR activation inhibitors, including a group of structurally related compounds comprising celastrol, gedunin, and derivatives. To develop an in silico approach for target pathway identification, we apply a gene expression-based analysis that classifies HSP90 inhibitors as having similar activity to celastrol and gedunin. Validating this prediction, we demonstrate that celastrol and gedunin inhibit HSP90 activity and HSP90 clients, including AR. Broadly, this work identifies new modes of HSP90 modulation through a gene expression-based strategy.</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue></record></records></xml>
