<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lu,Jun</style></author><author><style face="normal" font="default" size="100%">Guo,Shangqin</style></author><author><style face="normal" font="default" size="100%">Ebert,Benjamin L</style></author><author><style face="normal" font="default" size="100%">Zhang,Hao</style></author><author><style face="normal" font="default" size="100%">Peng,Xiao</style></author><author><style face="normal" font="default" size="100%">Bosco,Jocelyn</style></author><author><style face="normal" font="default" size="100%">Pretz,Jennifer</style></author><author><style face="normal" font="default" size="100%">Schlanger,Rita</style></author><author><style face="normal" font="default" size="100%">Wang,Judy Y</style></author><author><style face="normal" font="default" size="100%">Mak,Raymond H</style></author><author><style face="normal" font="default" size="100%">Dombkowski,David M</style></author><author><style face="normal" font="default" size="100%">Preffer,Frederic I</style></author><author><style face="normal" font="default" size="100%">Scadden,David T</style></author><author><style face="normal" font="default" size="100%">Golub,Todd R</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors</style></title><secondary-title><style face="normal" font="default" size="100%">Developmental Cell</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Antigens</style></keyword><keyword><style  face="normal" font="default" size="100%">Bone Marrow Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">CD34</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Differentiation</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Lineage</style></keyword><keyword><style  face="normal" font="default" size="100%">Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Cultured</style></keyword><keyword><style  face="normal" font="default" size="100%">Erythroid Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Erythropoietin</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Regulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Genes</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematopoietic Stem Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Integrin beta3</style></keyword><keyword><style  face="normal" font="default" size="100%">K562 Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Megakaryocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Mi</style></keyword><keyword><style  face="normal" font="default" size="100%">Reporter</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2008/06//</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/18539114</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">843 - 53</style></pages><isbn><style face="normal" font="default" size="100%">1534-5807</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Lineage specification is a critical issue in developmental and regenerative biology. We hypothesized that microRNAs (miRNAs) are important participants in those processes and used the poorly understood regulation of megakaryocyte-erythrocyte progenitors (MEPs) in hematopoiesis as a model system. We report here that miR-150 modulates lineage fate in MEPs. Using a novel methodology capable of profiling miRNA expression in small numbers of primary cells, we identify miR-150 as preferentially expressed in the megakaryocytic lineage. Through gain- and loss-of-function experiments, we demonstrate that miR-150 drives MEP differentiation toward megakaryocytes at the expense of erythroid cells in vitro and in vivo. Moreover, we identify the transcription factor MYB as a critical target of miR-150 in this regulation. These experiments show that miR-150 regulates MEP fate, and thus establish a role for miRNAs in lineage specification of mammalian multipotent cells.</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue></record></records></xml>
