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Recent Cancer Papers

The Genotype-Tissue Expression (GTEx) project.Lonsdale, J., Thomas J., Salvatore M., Phillips R., Lo E., Shad S., Hasz R., Walters G., Garcia F., Young N., Foster B., Moser M., Karasik E., Gillard B., Ramsey K., Sullivan S., Bridge J., Magazine H., Syron J., Fleming J., et al. Nature genetics, 2013/05/29, Volume 45, Issue 6, p.580-5, (2013) Read More / View Supplemental Materials
Selective HDAC1/HDAC2 Inhibitors Induce Neuroblastoma Differentiation.Frumm, SM, Fan ZP, Ross KN, Duvall JR, Gupta S., VerPlank L., Suh BC, Holson E., Wagner FF, Smith WB, Paranal RM, Bassil CF, Qi J., Roti G., Kung AL, Bradner JE, Tolliday N., and Stegmaier K. Chemistry & biology, 2013/05/23, Volume 20, Issue 5, p.713-25, (2013) Read More / View Supplemental Materials
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Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.Ramkissoon, LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A., Lawrence MS, Bergthold G., Brastianos PK, Tabak B., Ducar MD, Van Hummelen P., Macconaill LE, Pouissant-Young T., Cho YJ, Taha H., Mahmoud M., Bowers DC, Margraf L., et al. Proceedings of the National Academy of Sciences of the United States of America, 2013/05/14, Volume 110, Issue 20, p.8188-93, (2013) Read More / View Supplemental Materials
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Integrated genomic characterization of endometrial carcinoma.Cancer Genome Atlas Research, Network, Genome sequencing centres: Broad Institute, Getz G., Gabriel SB, Cibulskis K., Lander E., Sivachenko A., Sougnez C., Lawrence M., Washington University in St Louis, Kandoth C., Dooling D., Fulton R., Fulton L., Kalicki-Veizer J., McLellan MD, O'Laughlin M., Schmidt H., Wilson RK, Ye K., et al. Nature, 2013/05/02, Volume 497, Issue 7447, p.67-73, (2013) Read More / View Supplemental Materials
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Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia.The Cancer Genome Atlas Research, Network The New England journal of medicine, 2013/05/01, (2013) Read More / View Supplemental Materials
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Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.Dulak, AM, Stojanov P., Peng S., Lawrence MS, Fox C., Stewart C., Bandla S., Imamura Y., Schumacher SE, Shefler E., McKenna A., Carter SL, Cibulskis K., Sivachenko A., Saksena G., Voet D., Ramos AH, Auclair D., Thompson K., Sougnez C., et al. Nature genetics, 2013/04/26, Volume 45, Issue 5, p.478-86, (2013) Read More / View Supplemental Materials
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Punctuated evolution of prostate cancer genomes.Baca, SC, Prandi D., Lawrence MS, Mosquera JM, Romanel A., Drier Y., Park K., Kitabayashi N., MacDonald TY, Ghandi M., Van Allen E., Kryukov GV, Sboner A., Theurillat JP, Soong TD, Nickerson E., Auclair D., Tewari A., Beltran H., Onofrio RC, et al. Cell, 2013/04/25, Volume 153, Issue 3, p.666-77, (2013) Read More / View Supplemental Materials
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IKKε-Mediated Tumorigenesis Requires K63-Linked Polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 Ubiquitin Ligase Complex.Zhou, AY, Shen RR, Kim E., Lock YJ, Xu M., Chen ZJ, and Hahn WC Cell reports, 2013/03/28, Volume 3, Issue 3, p.724-33, (2013) Read More / View Supplemental Materials
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Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1.Tu, D., Zhu Z., Zhou AY, Yun CH, Lee KE, Toms AV, Li Y., Dunn GP, Chan E., Thai T., Yang S., Ficarro SB, Marto JA, Jeon H., Hahn WC, Barbie DA, and Eck MJ Cell reports, 2013/03/28, Volume 3, Issue 3, p.747-58, (2013) Read More / View Supplemental Materials
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Lessons from the cancer genome.Garraway, LA, and Lander E. S. Cell, 2013/03/28, Volume 153, Issue 1, p.17-37, (2013) Read More / View Supplemental Materials
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Evolution and impact of subclonal mutations in chronic lymphocytic leukemia.Landau, DA, Carter SL, Stojanov P., McKenna A., Stevenson K., Lawrence MS, Sougnez C., Stewart C., Sivachenko A., Wang L., Wan Y., Zhang W., Shukla SA, Vartanov A., Fernandes SM, Saksena G., Cibulskis K., Tesar B., Gabriel S., Hacohen N., et al. Cell, 2013/02/14, Volume 152, Issue 4, p.714-26, (2013) Read More / View Supplemental Materials
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Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples.Cibulskis, K., Lawrence MS, Carter SL, Sivachenko A., Jaffe D., Sougnez C., Gabriel S., Meyerson M., Lander E. S., and Getz G. Nature biotechnology, 2013/02/10, (2013) Read More / View Supplemental Materials
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Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.Chmielecki, J., Crago AM, Rosenberg M., O'Connor R., Walker SR, Ambrogio L., Auclair D., McKenna A., Heinrich MC, Frank DA, and Meyerson M. Nature genetics, 2013/02/01, Volume 45, Issue 2, p.131-2, (2013) Read More / View Supplemental Materials
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Highly Recurrent TERT Promoter Mutations in Human Melanoma.Huang, FW, Hodis E., Xu MJ, Kryukov GV, Chin L., and Garraway LA Science (New York, N.Y.), 2013/01/24, (2013) Read More / View Supplemental Materials
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The genetic landscape of high-risk neuroblastoma.Pugh, TJ, Morozova O., Attiyeh EF, Asgharzadeh S., Wei JS, Auclair D., Carter SL, Cibulskis K., Hanna M., Kiezun A., Kim J., Lawrence MS, Lichenstein L., McKenna A., Pedamallu CS, Ramos AH, Shefler E., Sivachenko A., Sougnez C., Stewart C., et al. Nature genetics, 2013/01/20, (2013) Read More / View Supplemental Materials
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Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.Brastianos, PK, Horowitz PM, Santagata S., Jones RT, McKenna A., Getz G., Ligon KL, Palescandolo E., Van Hummelen P., Ducar MD, Raza A., Sunkavalli A., Macconaill LE, Stemmer-Rachamimov AO, Louis DN, Hahn WC, Dunn IF, and Beroukhim R. Nature genetics, 2013/01/20, (2013) Read More / View Supplemental Materials
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Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation.Costello, M., Pugh TJ, Fennell TJ, Stewart C., Lichtenstein L., Meldrim JC, Fostel JL, Friedrich DC, Perrin D., Dionne D., Kim S., Gabriel SB, Lander E. S., Fisher S., and Getz G. Nucleic acids research, 2013/01/08, (2013) Read More / View Supplemental Materials
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A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.Whittaker, SR, Theurillat JP, Van Allen E., Wagle N., Hsiao J., Cowley GS, Schadendorf D., Root DE, and Garraway LA Cancer discovery, 2013/01/03, (2013) Read More / View Supplemental Materials
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ATARiS: Computational quantification of gene suppression phenotypes from multi-sample RNAi screens.Shao, DD, Tsherniak A., Gopal S., Weir BA, Tamayo P., Stransky N., Schumacher SE, Zack TI, Beroukhim R., Garraway LA, Margolin AA, Root DE, Hahn WC, and Mesirov J. P. Genome research, 2012/12/26, (2012) Read More / View Supplemental Materials
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β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis.Rosenbluh, J., Nijhawan D., Cox AG, Li X., Neal JT, Schafer EJ, Zack TI, Wang X., Tsherniak A., Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F., Cowley GS, Root DE, Mesirov J. P., Beroukhim R., Kuo CJ, Goessling W., et al. Cell, 2012/12/21, Volume 151, Issue 7, p.1457-73, (2012) Read More / View Supplemental Materials
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Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.Imielinski, M., Berger AH, Hammerman PS, Hernandez B., Pugh TJ, Hodis E., Cho J., Suh J., Capelletti M., Sivachenko A., Sougnez C., Auclair D., Lawrence MS, Stojanov P., Cibulskis K., Choi K., de Waal L., Sharifnia T., Brooks A., Greulich H., et al. Cell, 2012/09/14, Volume 150, Issue 6, p.1107-20, (2012) Read More / View Supplemental Materials
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Comprehensive genomic characterization of squamous cell lung cancers.The Cancer Genome Atlas Research, Network, institution.)(Participants are arranged by area of contribution and then by, Genome sequencing centres: Broad Institute, Hammerman PS, Lawrence MS, Voet D., Jing R., Cibulskis K., Sivachenko A., Stojanov P., McKenna A., Lander E. S., Gabriel S., Getz G., Sougnez C., Imielinski M., Helman E., Hernandez B., Pho NH, Meyerson M., et al. Nature, 2012/09/09, (2012) Read More / View Supplemental Materials
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Cancer vulnerabilities unveiled by genomic loss.Nijhawan, D., Zack TI, Ren Y., Strickland MR, Lamothe R., Schumacher SE, Tsherniak A., Besche HC, Rosenbluh J., Shehata S., Cowley GS, Weir BA, Goldberg AL, Mesirov J. P., Root DE, Bhatia SN, Beroukhim R., and Hahn WC Cell, 2012/08/17, Volume 150, Issue 4, p.842-54, (2012) Read More / View Supplemental Materials
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Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4.Ren, Y., Cheung HW, von Maltzhan G., Agrawal A., Cowley GS, Weir BA, Boehm JS, Tamayo P., Karst AM, Liu JF, Hirsch MS, Mesirov J. P., Drapkin R., Root DE, Lo J., Fogal V., Ruoslahti E., Hahn WC, and Bhatia SN Science translational medicine, 2012/08/15, Volume 4, Issue 147, p.147ra112, (2012) Read More / View Supplemental Materials
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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.Pugh, TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D., Bochicchio J., Carneiro MO, Carter SL, Cibulskis K., Erlich RL, Greulich H., Lawrence MS, Lennon NJ, McKenna A., Meldrim J., Ramos AH, Ross MG, Russ C., Shefler E., Sivachenko A., et al. Nature, 2012/08/02, Volume 488, Issue 7409, p.106-10, (2012) Read More / View Supplemental Materials
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A landscape of driver mutations in melanoma.Hodis, E., Watson IR, Kryukov GV, Arold ST, Imielinski M., Theurillat JP, Nickerson E., Auclair D., Li L., Place C., Dicara D., Ramos AH, Lawrence MS, Cibulskis K., Sivachenko A., Voet D., Saksena G., Stransky N., Onofrio RC, Winckler W., et al. Cell, 2012/07/20, Volume 150, Issue 2, p.251-63, (2012) Read More / View Supplemental Materials
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Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency.Wei, G., Margolin AA, Haery L., Brown E., Cucolo L., Julian B., Shehata S., Kung AL, Beroukhim R., and Golub T. R. Cancer cell, 2012/04/17, Volume 21, Issue 4, p.547-62, (2012) Read More / View Supplemental Materials
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.Barretina, J., Caponigro G., Stransky N., Venkatesan K., Margolin AA, Kim S., Wilson CJ, Lehár J., Kryukov GV, Sonkin D., Reddy A., Liu M., Murray L., Berger MF, Monahan JE, Morais P., Meltzer J., Korejwa A., Jané-Valbuena J., Mapa FA, et al. Nature, 2012/03/28, Volume 483, Issue 7391, p.603-7, (2012) Read More / View Supplemental Materials
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High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing.Wagle, N., Berger MF, Davis MJ, Blumenstiel B., DeFelice M., Pochanard P., Ducar M., Van Hummelen P., Macconaill LE, Hahn WC, Meyerson M., Gabriel SB, and Garraway LA Cancer discovery, 2012/01/01, Volume 2, Issue 1, p.82-93, (2012) Read More / View Supplemental Materials
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Genomic analysis identifies association of Fusobacterium with colorectal carcinoma.Kostic, AD, Gevers D., Pedamallu CS, Michaud M., Duke F., Earl AM, Ojesina AI, Jung J., Bass AJ, Tabernero J., Baselga J., Liu C., Shivdasani RA, Ogino S., Birren BW, Huttenhower C., Garrett WS, and Meyerson M. Genome research, 2011/10/18, (2011) Read More / View Supplemental Materials
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Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.Cheung, HW, Cowley GS, Weir BA, Boehm JS, Rusin S., Scott JA, East A., Ali LD, Lizotte PH, Wong TC, Jiang G., Hsiao J., Mermel CH, Getz G., Barretina J., Gopal S., Tamayo P., Gould J., Tsherniak A., Stransky N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2011/07/26, Volume 108, Issue 30, p.12372-7, (2011) Read More / View Supplemental Materials
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