Recent Cancer Papers

Integrated genetic and pharmacologic interrogation of rare cancers.Hong, AL, Tseng YY, Cowley GS, Jonas O., Cheah JH, Kynnap BD, Doshi MB, Oh C., Meyer SC, Church AJ, Gill S., Bielski CM, Keskula P., Imamovic A., Howell S., Kryukov GV, Clemons PA, Tsherniak A., Vazquez F., Crompton BD, et al. Nature communications, 2016/06/22, Volume 7, p.11987, (2016) Read More / View Supplemental Materials
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Targeting MTHFD2 in acute myeloid leukemia.Pikman, Y., Puissant A., Alexe G., Furman A., Chen LM, Frumm SM, Ross L., Fenouille N., Bassil CF, Lewis CA, Ramos A., Gould J., Stone RM, DeAngelo DJ, Galinsky I., Clish CB, Kung AL, Hemann MT, Vander Heiden MG, Banerji V., et al. The Journal of experimental medicine, 2016/06/20, (2016) Read More / View Supplemental Materials
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Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAP kinase pathway mutations.Louissaint A, Jr, Schafernak KT, Geyer J., Kovach AE, Ghandi M., Gratzinger D., Roth CG, Paxton CN, Kim S., Namgyal C., Morgan EA, Neuberg DS, South ST, Harris MH, Hasserjian RP, Hochberg EP, Garraway LA, Harris NL, and Weinstock DM Blood, 2016/06/20, (2016) Read More / View Supplemental Materials
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Genomic copy number dictates a gene-independent cell response to CRISPR-Cas9 targeting.Aguirre, AJ, Meyers RM, Weir BA, Vazquez F., Zhang CZ, Ben-David U., Cook A., Ha G., Harrington WF, Doshi MB, Kost-Alimova M., Gill S., Xu H., Ali LD, Jiang G., Pantel S., Lee Y., Goodale A., Cherniack AD, Oh C., et al. Cancer discovery, 2016/06/03, (2016) Read More / View Supplemental Materials
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Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition.Burger, JA, Landau DA, Taylor-Weiner A., Bozic I., Zhang H., Sarosiek K., Wang L., Stewart C., Fan J., Hoellenriegel J., Sivina M., Dubuc AM, Fraser C., Han Y., Li S., Livak KJ, Zou L., Wan Y., Konoplev S., Sougnez C., et al. Nature communications, 2016/05/20, Volume 7, p.11589, (2016) Read More / View Supplemental Materials
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Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth.Holst, F., Hoivik EA, Gibson WJ, Taylor-Weiner A., Schumacher SE, Asmann YW, Grossmann P., Trovik J., Necela BM, Thompson EA, Meyerson M., Beroukhim R., Salvesen HB, and Cherniack AD Scientific reports, 2016/05/10, Volume 6, p.25521, (2016) Read More / View Supplemental Materials
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Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas.Campbell, JD, Alexandrov A., Kim J., Wala J., Berger AH, Pedamallu CS, Shukla SA, Guo G., Brooks AN, Murray BA, Imielinski M., Hu X., Ling S., Akbani R., Rosenberg M., Cibulskis C., Ramachandran A., Collisson EA, Kwiatkowski DJ, Lawrence MS, et al. Nature genetics, 2016/05/09, (2016) Read More / View Supplemental Materials
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Systematic functional interrogation of rare cancer variants identifies oncogenic alleles.Kim, E., Ilic N., Shrestha Y., Zou L., Kamburov A., Zhu C., Yang X., Lubonja R., Tran N., Nguyen C., Lawrence MS, Piccioni F., Bagul M., Doench JG, Chouinard CR, Wu X., Hogstrom L., Natoli T., Tamayo P., Horn H., et al. Cancer discovery, 2016/05/04, (2016) Read More / View Supplemental Materials
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Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors.Kim, J., Mouw KW, Polak P., Braunstein LZ, Kamburov A., Tiao G., Kwiatkowski DJ, Rosenberg JE, Van Allen EM, D'Andrea AD, and Getz G. Nature genetics, 2016/04/25, (2016) Read More / View Supplemental Materials
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Characterizing genomic alterations in cancer by complementary functional associations.Kim, JW, Botvinnik OB, Abudayyeh O., Birger C., Rosenbluh J., Shrestha Y., Abazeed ME, Hammerman PS, Dicara D., Konieczkowski DJ, Johannessen CM, Liberzon A., Alizad-Rahvar AR, Alexe G., Aguirre A., Ghandi M., Greulich H., Vazquez F., Weir BA, Van Allen EM, et al. Nature biotechnology, 2016/04/18, (2016) Read More / View Supplemental Materials
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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.Tirosh, I., Izar B., Prakadan SM, Wadsworth MH 2nd, Treacy D., Trombetta JJ, Rotem A., Rodman C., Lian C., Murphy G., Fallahi-Sichani M., Dutton-Regester K., Lin JR, Cohen O., Shah P., Lu D., Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, et al. Science (New York, N.Y.), 2016/04/08, Volume 352, Issue 6282, p.189-96, (2016) Read More / View Supplemental Materials
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Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.Puram, RV, Kowalczyk MS, de Boer CG, Schneider RK, Miller PG, McConkey M., Tothova Z., Tejero H., Heckl D., Järås M., Chen MC, Li H., Tamayo A., Cowley GS, Rozenblatt-Rosen O., Al-Shahrour F., Regev A., and Ebert BL Cell, 2016/04/07, Volume 165, Issue 2, p.303-16, (2016) Read More / View Supplemental Materials
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Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9.Schneider, RK, Schenone M., Ferreira MV, Kramann R., Joyce CE, Hartigan C., Beier F., Brümmendorf TH, Germing U., Platzbecker U., Büsche G., Knüchel R., Chen MC, Waters CS, Chen E., Chu LP, Novina CD, Lindsley RC, Carr SA, and Ebert BL Nature medicine, 2016/03/01, Volume 22, Issue 3, p.288-97, (2016) Read More / View Supplemental Materials
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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.Yu, C., Mannan AM, Yvone GM, Ross KN, Zhang YL, Marton MA, Taylor BR, Crenshaw A., Gould JZ, Tamayo P., Weir BA, Tsherniak A., Wong B., Garraway LA, Shamji AF, Palmer MA, Foley MA, Winckler W., Schreiber SL, Kung AL, et al. Nature biotechnology, 2016/02/29, (2016) Read More / View Supplemental Materials
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MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.Kryukov, GV, Wilson FH, Ruth JR, Paulk J., Tsherniak A., Marlow SE, Vazquez F., Weir BA, Fitzgerald ME, Tanaka M., Bielski CM, Scott JM, Dennis C., Cowley GS, Boehm JS, Root DE, Golub T. R., Clish CB, Bradner JE, Hahn WC, et al. Science (New York, N.Y.), 2016/02/11, (2016) Read More / View Supplemental Materials
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Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.de Waal, L., Lewis TA, Rees MG, Tsherniak A., Wu X., Choi PS, Hartigan C., Faloon PW, Hickey MJ, Tolliday N., Carr SA, Clemons PA, Munoz B., Wagner BK, Shamji AF, Koehler AN, Schenone M., Burgin AB, Schreiber SL, Greulich H., et al. Nature chemical biology, 2016/02/01, Volume 12, Issue 2, p.102-8, (2016) Read More / View Supplemental Materials
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Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy.Gannon, HS, Kaplan N., Tsherniak A., Vazquez F., Weir BA, Hahn WC, and Meyerson M. Molecular cancer research : MCR, 2016/02/01, Volume 14, Issue 2, p.207-15, (2016) Read More / View Supplemental Materials
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Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair.Haradhvala, NJ, Polak P., Stojanov P., Covington KR, Shinbrot E., Hess JM, Rheinbay E., Kim J., Maruvka YE, Braunstein LZ, Kamburov A., Hanawalt PC, Wheeler DA, Koren A., Lawrence MS, and Getz G. Cell, 2016/01/20, (2016) Read More / View Supplemental Materials
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TERT promoter mutations and monoallelic activation of TERT in cancer.Huang, FW, Bielski CM, Rinne ML, Hahn WC, Sellers WR, Stegmeier F., Garraway LA, and Kryukov GV Oncogenesis, 2015/12/14, Volume 4, p.e176, (2015) Read More / View Supplemental Materials
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Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers.Zhang, X., Choi PS, Francis JM, Imielinski M., Watanabe H., Cherniack AD, and Meyerson M. Nature genetics, 2015/12/14, (2015) Read More / View Supplemental Materials
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Pharmacogenomic agreement between two cancer cell line data sets.Cancer Cell Line Encyclopedia, Consortium, and Genomics of Drug Sensitivity in Cancer Consortium Nature, 2015/12/03, Volume 528, Issue 7580, p.84-7, (2015) Read More / View Supplemental Materials
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Comprehensive assessment of cancer missense mutation clustering in protein structures.Kamburov, A., Lawrence MS, Polak P., Leshchiner I., Lage K., Golub T. R., Lander E. S., and Getz G. Proceedings of the National Academy of Sciences of the United States of America, 2015/10/06, Volume 112, Issue 40, p.E5486-95, (2015) Read More / View Supplemental Materials
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