Scientific Publications

DNA microarrays in clinical oncology

Publication TypeJournal Article
AuthorsRamaswamy, Sridhar, and Golub Todd R.
AbstractAberrant gene expression is critical for tumor initiation and progression. However, we lack a comprehensive understanding of all genes that are aberrantly expressed in human cancer. Recently, DNA microarrays have been used to obtain global views of human cancer gene expression and to identify genetic markers that might be important for diagnosis and therapy. We review clinical applications of these novel tools, discuss some important recent studies, identify promising avenues of research in this emerging field of study, and discuss the likely impact that expression profiling will have on clinical oncology.
Year of Publication2002
JournalJournal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Volume20
Issue7
Pages1932 - 41
Date Published (YYYY/MM/DD)2002/04/01/
ISBN Number0732-183X
KeywordsCancer, Gene Expression Profiling, Gene Expression Regulation, Humans, Neoplasms, Neoplastic, Oligonucleotide Array Sequence Analysis