Scientific Publications

A molecular signature of metastasis in primary solid tumors

Publication TypeJournal Article
AuthorsRamaswamy, Sridhar, Ross Ken N., Lander Eric S., and Golub Todd R.
AbstractMetastasis is the principal event leading to death in individuals with cancer, yet its molecular basis is poorly understood. To explore the molecular differences between human primary tumors and metastases, we compared the gene-expression profiles of adenocarcinoma metastases of multiple tumor types to unmatched primary adenocarcinomas. We found a gene-expression signature that distinguished primary from metastatic adenocarcinomas. More notably, we found that a subset of primary tumors resembled metastatic tumors with respect to this gene-expression signature. We confirmed this finding by applying the expression signature to data on 279 primary solid tumors of diverse types. We found that solid tumors carrying the gene-expression signature were most likely to be associated with metastasis and poor clinical outcome (P < 0.03). These results suggest that the metastatic potential of human tumors is encoded in the bulk of a primary tumor, thus challenging the notion that metastases arise from rare cells within a primary tumor that have the ability to metastasize.
Year of Publication2003
JournalNature Genetics
Volume33
Issue1
Pages49 - 54
Date Published (YYYY/MM/DD)2003/01//
ISBN Number1061-4036
KeywordsAdenocarcinoma, Cancer, Gene Expression Profiling, Gene Expression Regulation, Humans, Neoplasm Metastasis, Neoplasms, Neoplastic, Organ Specificity, Predictive Value of Tests, Prognosis, Survival Analysis
Supplemental Materials
http://www.broadinstitute.org/cgi-bin/cancer/publications/pub_paper.cgi?mode=view&paper_id=80
Evidence for a Molecular Signature of Metastasis in Primary Solid Tumors