Scientific Publications

Estimating dataset size requirements for classifying DNA microarray data

Publication TypeJournal Article
AuthorsMukherjee, Sayan, Tamayo Pablo, Rogers Simon, Rifkin Ryan, Engle Anna, Campbell Colin, Golub Todd R., and Mesirov Jill P.
AbstractA statistical methodology for estimating dataset size requirements for classifying microarray data using learning curves is introduced. The goal is to use existing classification results to estimate dataset size requirements for future classification experiments and to evaluate the gain in accuracy and significance of classifiers built with additional data. The method is based on fitting inverse power-law models to construct empirical learning curves. It also includes a permutation test procedure to assess the statistical significance of classification performance for a given dataset size. This procedure is applied to several molecular classification problems representing a broad spectrum of levels of complexity.
Year of Publication2003
JournalJournal of Computational Biology: A Journal of Computational Molecular Cell Biology
Pages119 - 42
Date Published (YYYY/MM/DD)2003///
ISBN Number1066-5277
KeywordsAlgorithms, Cancer, Computational Biology, Computer Simulation, Gene Expression Profiling, Humans, Models, Molecular, Neoplasms, Oligonucleotide Array Sequence Analysis