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A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer

Publication TypeJournal Article
AuthorsLamb, Justin, Ramaswamy Sridhar, Ford Heide L., Contreras Bernardo, Martinez Robert V., Kittrell Frances S., Zahnow Cynthia A., Patterson Nick, Golub Todd R., and Ewen Mark E.
AbstractHere we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene. Computational analysis of the expression patterns of thousands of genes across hundreds of tumor specimens suggested that a transcription factor, C/EBPbeta/Nf-Il6, participates in the consequences of cyclin D1 overexpression. Functional analyses confirmed the involvement of C/EBPbeta in the regulation of genes affected by cyclin D1 and established this protein as an indispensable effector of a potentially important facet of cyclin D1 biology. This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ.
Year of Publication2003
JournalCell
Volume114
Issue3
Pages323 - 34
Date Published (YYYY/MM/DD)2003/08/08/
ISBN Number0092-8674
KeywordsCancer, CCAAT-Enhancer-Binding Protein-beta, Cyclin D1, Databases, Gene Expression Profiling, Gene Expression Regulation, Genetic, Humans, Neoplasm Proteins, Neoplasms, Neoplastic, Oligonucleotide Array Sequence Analysis, Promoter Regions (Genetics), Statistics