Investigation of Genetic Variation Underlying Central Obesity amongst South Asians.
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Abstract | South Asians are 1/4 of the world's population and have increased susceptibility to central obesity and related cardiometabolic disease. Knowledge of genetic variants affecting risk of central obesity is largely based on genome-wide association studies of common SNPs in Europeans. To evaluate the contribution of DNA sequence variation to the higher levels of central obesity (defined as waist hip ratio adjusted for body mass index, WHR) among South Asians compared to Europeans we carried out: i) a genome-wide association analysis of >6M genetic variants in 10,318 South Asians with focused analysis of population-specific SNPs; ii) an exome-wide association analysis of ~250K SNPs in protein-coding regions in 2,637 South Asians; iii) a comparison of risk allele frequencies and effect sizes of 48 known WHR SNPs in 12,240 South Asians compared to Europeans. In genome-wide analyses, we found no novel associations between common genetic variants and WHR in South Asians at P |
Year of Publication | 2016
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Journal | PLoS One
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Volume | 11
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Issue | 5
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Pages | e0155478
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Date Published | 2016
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ISSN | 1932-6203
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URL | |
DOI | 10.1371/journal.pone.0155478
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PubMed ID | 27195708
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PubMed Central ID | PMC4873263
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Links | |
Grant list | MR/K002414/1 / Medical Research Council / United Kingdom
G0700931 / Medical Research Council / United Kingdom
G0601966 / Medical Research Council / United Kingdom
R01 DK082766 / DK / NIDDK NIH HHS / United States
RP-PG-0407-10371 / Department of Health / United Kingdom
K01 TW006087 / TW / FIC NIH HHS / United States
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