Trained immunity: A program of innate immune memory in health and disease.

Science
Authors
Keywords
Abstract

The general view that only adaptive immunity can build immunological memory has recently been challenged. In organisms lacking adaptive immunity, as well as in mammals, the innate immune system can mount resistance to reinfection, a phenomenon termed "trained immunity" or "innate immune memory." Trained immunity is orchestrated by epigenetic reprogramming, broadly defined as sustained changes in gene expression and cell physiology that do not involve permanent genetic changes such as mutations and recombination, which are essential for adaptive immunity. The discovery of trained immunity may open the door for novel vaccine approaches, new therapeutic strategies for the treatment of immune deficiency states, and modulation of exaggerated inflammation in autoinflammatory diseases.

Year of Publication
2016
Journal
Science
Volume
352
Issue
6284
Pages
aaf1098
Date Published
2016 Apr 22
ISSN
1095-9203
URL
DOI
10.1126/science.aaf1098
PubMed ID
27102489
PubMed Central ID
PMC5087274
Links
Grant list
P30 DK043351 / DK / NIDDK NIH HHS / United States