Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes.

PLoS One
Authors
Keywords
Abstract

BACKGROUND: Although obesity and cardiometabolic traits commonly overlap, underlying pathways remain incompletely defined. The association of metabolite profiles across multiple cardiometabolic traits may lend insights into the interaction of obesity and metabolic health. We sought to investigate metabolic signatures of obesity and related cardiometabolic traits in the community using broad-based metabolomic profiling.

METHODS AND RESULTS: We evaluated the association of 217 assayed metabolites and cross-sectional as well as longitudinal changes in cardiometabolic traits among 2,383 Framingham Offspring cohort participants. Body mass index (BMI) was associated with 69 of 217 metabolites (P

CONCLUSIONS: In this large-scale metabolite profiling study, body mass index was associated with a broad range of metabolic alterations. Metabolite profiling highlighted considerable overlap with abdominal adiposity, insulin resistance, and dyslipidemia, but not with fasting glucose or blood pressure traits.

Year of Publication
2016
Journal
PLoS One
Volume
11
Issue
2
Pages
e0148361
Date Published
2016
ISSN
1932-6203
URL
DOI
10.1371/journal.pone.0148361
PubMed ID
26863521
PubMed Central ID
PMC4749349
Links
Grant list
2R01-DK081572 / DK / NIDDK NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
HHSN268201500001C / HL / NHLBI NIH HHS / United States
R01 DK081572 / DK / NIDDK NIH HHS / United States
K23-HL116780 / HL / NHLBI NIH HHS / United States
HHSN268201500001I / HL / NHLBI NIH HHS / United States
K23 HL116780 / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States