Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry.

Hum Mol Genet

Authors	Jonine Figueroa Candace Middlebrooks A Rouf Banday Yuanqing Ye Montserrat García-Closas Nilanjan Chatterjee Stella Koutros Lambertus Kiemeney Thorunn Rafnar Timothy Bishop Helena Furberg Giuseppe Matullo Klaus Golka Manuela Gago-Dominguez Jack Taylor Tony Fletcher Afshan Siddiq Victoria Cortessis Charles Kooperberg Olivier Cussenot Simone Benhamou Jennifer Prescott Stefano Porru Colin Dinney Nuria Malats Dalsu Baris Mark Purdue Eric Jacobs Demetrius Albanes Zhaoming Wang Charles Chung Sita Vermeulen Katja Aben Tessel Galesloot Gudmar Thorleifsson Patrick Sulem Kari Stefansson Anne Kiltie Mark Harland Mark Teo Kenneth Offit Joseph Vijai Dean Bajorin Ryan Kopp Giovanni Fiorito Simonetta Guarrera Carlotta Sacerdote Silvia Selinski Jan Hengstler Holger Gerullis Daniel Ovsiannikov Meinolf Blaszkewicz Jose Castelao Manuel Calaza Maria Martinez Patricia Cordeiro Zongli Xu Vijayalakshmi Panduri Raj Kumar iv Eugene Gurzau Kvetoslava Koppova H Bas Bueno-de-Mesquita Börje Ljungberg Francoise Clavel-Chapelon Elisabete Weiderpass Vittorio Krogh Miren Dorronsoro Ruth Travis Anne Tjønneland Paul Brennan Jenny Chang-Claude Elio Riboli David Conti Marianna Stern Malcolm Pike David Van Den Berg Jian-Min Yuan Chancellor Hohensee Rebecca Jeppson Geraldine Cancel-Tassin Morgan Roupret Eva Comperat Constance Turman Immaculata De Vivo Edward Giovannucci David Hunter Peter Kraft Sara Lindström Angela Carta Sofia Pavanello Cecilia Arici Giuseppe Mastrangelo Ashish Kamat Liren Zhang Yilei Gong Xia Pu Amy Hutchinson Laurie Burdett William Wheeler Margaret Karagas Alison Johnson Alan Schned G Hosain Molly Schwenn Manolis Kogevinas Adonina Tardon Consol Serra Alfredo Carrato Reina Garcia-Closas Josep Lloreta Gerald Andriole Robert Grubb Amanda Black W Ryan Diver Susan Gapstur Stephanie Weinstein Jarmo Virtamo Christopher Haiman Maria Landi Neil Caporaso Joseph Fraumeni Paolo Vineis Xifeng Wu Stephen Chanock Debra Silverman Ludmila Prokunina-Olsson Nathaniel Rothman
Keywords	Female Humans Male Genetic Predisposition to Disease Risk Factors Genome-Wide Association Study Polymorphism, Single Nucleotide Linkage Disequilibrium Case-Control Studies Genetic Association Studies European Continental Ancestry Group Chromosomes, Human, Pair 13 Biomarkers, Tumor Chromosomes, Human, Pair 20 Urinary Bladder Neoplasms
Abstract	Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic regions associated with bladder cancer risk. In search for additional susceptibility variants, we followed up on four promising single-nucleotide polymorphisms (SNPs) that had not achieved genome-wide significance in 6911 cases and 11 814 controls (rs6104690, rs4510656, rs5003154 and rs4907479, P
Year of Publication	2016
Journal	Hum Mol Genet
Volume	25
Issue	6
Pages	1203-14
Date Published	2016 Mar 15
ISSN	1460-2083
URL	http://hmg.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=26732427
DOI	10.1093/hmg/ddv492
PubMed ID	26732427
PubMed Central ID	PMC4817084
Links	Google Scholar PubMed DOI
Grant list	P50 CA091846 / CA / NCI NIH HHS / United States U01 HG004438 / HG / NHGRI NIH HHS / United States P30 CA008748 / CA / NCI NIH HHS / United States 10589 / Cancer Research UK / United Kingdom U01 CA164973 / CA / NCI NIH HHS / United States

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