Emerging Frontiers in Drug Delivery.

J Am Chem Soc
Authors
Keywords
Abstract

Medicine relies on the use of pharmacologically active agents (drugs) to manage and treat disease. However, drugs are not inherently effective; the benefit of a drug is directly related to the manner by which it is administered or delivered. Drug delivery can affect drug pharmacokinetics, absorption, distribution, metabolism, duration of therapeutic effect, excretion, and toxicity. As new therapeutics (e.g., biologics) are being developed, there is an accompanying need for improved chemistries and materials to deliver them to the target site in the body, at a therapeutic concentration, and for the required period of time. In this Perspective, we provide an historical overview of drug delivery and controlled release followed by highlights of four emerging areas in the field of drug delivery: systemic RNA delivery, drug delivery for localized therapy, oral drug delivery systems, and biologic drug delivery systems. In each case, we present the barriers to effective drug delivery as well as chemical and materials advances that are enabling the field to overcome these hurdles for clinical impact.

Year of Publication
2016
Journal
J Am Chem Soc
Volume
138
Issue
3
Pages
704-17
Date Published
2016 Jan 27
ISSN
1520-5126
URL
DOI
10.1021/jacs.5b09974
PubMed ID
26741786
Links
Grant list
F32 HL122009 / HL / NHLBI NIH HHS / United States
F32HL122009 / HL / NHLBI NIH HHS / United States
R37EB000244 / EB / NIBIB NIH HHS / United States