Advances in discovering small molecules to probe protein function in a systems context.

Curr Opin Chem Biol
Authors
Keywords
Abstract

High throughput screening (HTS) has historically been used for drug discovery almost exclusively by the pharmaceutical industry. Due to a significant decrease in costs associated with establishing a high throughput facility and an exponential interest in discovering probes of development and disease associated biomolecules, HTS core facilities have become an integral part of most academic and non-profit research institutions over the past decade. This major shift has led to the development of new HTS methodologies extending beyond the capabilities and target classes used in classical drug discovery approaches such as traditional enzymatic activity-based screens. In this brief review we describe some of the most interesting developments in HTS technologies and methods for chemical probe discovery.

Year of Publication
2016
Journal
Curr Opin Chem Biol
Volume
30
Pages
28-36
Date Published
2016 Feb
ISSN
1879-0402
URL
DOI
10.1016/j.cbpa.2015.10.032
PubMed ID
26615565
PubMed Central ID
PMC4731259
Links
Grant list
R01 CA160860 / CA / NCI NIH HHS / United States