Constellation Map: Downstream visualization and interpretation of gene set enrichment results.

F1000Res
Authors
Abstract

UNLABELLED: Gene set enrichment analysis (GSEA) approaches are widely used to identify coordinately regulated genes associated with phenotypes of interest. Here, we present Constellation Map, a tool to visualize and interpret the results when enrichment analyses yield a long list of significantly enriched gene sets. Constellation Map identifies commonalities that explain the enrichment of multiple top-scoring gene sets and maps the relationships between them. Constellation Map can help investigators take full advantage of GSEA and facilitates the biological interpretation of enrichment results.

AVAILABILITY: Constellation Map is freely available as a GenePattern module at http://www.genepattern.org.

Year of Publication
2015
Journal
F1000Res
Volume
4
Pages
167
Date Published
2015
URL
DOI
10.12688/f1000research.6644.1
PubMed ID
26594333
PubMed Central ID
PMC4648224
Links
Grant list
R01 CA121941 / CA / NCI NIH HHS / United States
R01 GM074024 / GM / NIGMS NIH HHS / United States