Shared genetic aetiology of puberty timing between sexes and with health-related outcomes.

Nat Commun
Authors
Keywords
Abstract

Understanding of the genetic regulation of puberty timing has come largely from studies of rare disorders and population-based studies in women. Here, we report the largest genomic analysis for puberty timing in 55,871 men, based on recalled age at voice breaking. Analysis across all genomic variants reveals strong genetic correlation (0.74, P=2.7 × 10(-70)) between male and female puberty timing. However, some loci show sex-divergent effects, including directionally opposite effects between sexes at the SIM1/MCHR2 locus (Pheterogeneity=1.6 × 10(-12)). We find five novel loci for puberty timing (P

Year of Publication
2015
Journal
Nat Commun
Volume
6
Pages
8842
Date Published
2015 Nov 09
ISSN
2041-1723
URL
DOI
10.1038/ncomms9842
PubMed ID
26548314
PubMed Central ID
PMC4667609
Links
Grant list
U106179472 / Medical Research Council / United Kingdom
MC_UU_12015/2 / Medical Research Council / United Kingdom
U106179471 / Medical Research Council / United Kingdom
MC_U106179471 / Medical Research Council / United Kingdom
R44HG006981 / HG / NHGRI NIH HHS / United States
R44 HG006981 / HG / NHGRI NIH HHS / United States
MC_U106179472 / Medical Research Council / United Kingdom