Shared genetic aetiology of puberty timing between sexes and with health-related outcomes.
Nat Commun
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Abstract | Understanding of the genetic regulation of puberty timing has come largely from studies of rare disorders and population-based studies in women. Here, we report the largest genomic analysis for puberty timing in 55,871 men, based on recalled age at voice breaking. Analysis across all genomic variants reveals strong genetic correlation (0.74, P=2.7 × 10(-70)) between male and female puberty timing. However, some loci show sex-divergent effects, including directionally opposite effects between sexes at the SIM1/MCHR2 locus (Pheterogeneity=1.6 × 10(-12)). We find five novel loci for puberty timing (P |
Year of Publication | 2015
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Journal | Nat Commun
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Volume | 6
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Pages | 8842
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Date Published | 2015 Nov 09
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ISSN | 2041-1723
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URL | |
DOI | 10.1038/ncomms9842
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PubMed ID | 26548314
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PubMed Central ID | PMC4667609
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Grant list | U106179472 / Medical Research Council / United Kingdom
MC_UU_12015/2 / Medical Research Council / United Kingdom
U106179471 / Medical Research Council / United Kingdom
MC_U106179471 / Medical Research Council / United Kingdom
R44HG006981 / HG / NHGRI NIH HHS / United States
R44 HG006981 / HG / NHGRI NIH HHS / United States
MC_U106179472 / Medical Research Council / United Kingdom
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