Rare Coding Variation and Risk of Intracerebral Hemorrhage.

Stroke
Authors
Keywords
Abstract

BACKGROUND AND PURPOSE: Intracerebral hemorrhage has a substantial genetic component. We performed a preliminary search for rare coding variants associated with intracerebral hemorrhage.

METHODS: A total of 757 cases and 795 controls were genotyped using the Illumina HumanExome Beadchip (Illumina, Inc, San Diego, CA). Meta-analyses of single-variant and gene-based association were computed.

RESULTS: No rare coding variants were associated with intracerebral hemorrhage. Three common variants on chromosome 19q13 at an established susceptibility locus, encompassing TOMM40, APOE, and APOC1, met genome-wide significance (P

CONCLUSIONS: Although no coding variants of large effect were detected, this study further underscores a major challenge for the study of genetic susceptibility loci; large sample sizes are required for sufficient power except for loci with large effects.

Year of Publication
2015
Journal
Stroke
Volume
46
Issue
8
Pages
2299-301
Date Published
2015 Aug
ISSN
1524-4628
URL
DOI
10.1161/STROKEAHA.115.009838
PubMed ID
26111891
PubMed Central ID
PMC4519408
Links
Grant list
K23 NS059774 / NS / NINDS NIH HHS / United States
5K23NS059774 / NS / NINDS NIH HHS / United States
K23 NS086873 / NS / NINDS NIH HHS / United States
U10 NS077311 / NS / NINDS NIH HHS / United States
K23 NS042695 / NS / NINDS NIH HHS / United States
P50 AG005134 / AG / NIA NIH HHS / United States
R01 NS059727 / NS / NINDS NIH HHS / United States
R01NS059727 / NS / NINDS NIH HHS / United States
R01 NS073344 / NS / NINDS NIH HHS / United States
R01 NS036695 / NS / NINDS NIH HHS / United States
R01NS073344 / NS / NINDS NIH HHS / United States